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Pilot and Feasibility Studies

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https://www.readbyqxmd.com/read/29760941/hip-fracture-in-the-elderly-multidisciplinary-rehabilitation-femur-feasibility-study-testing-the-use-of-routinely-collected-data-for-future-health-economic-evaluations
#1
Nefyn H Williams, Kevin Mawdesley, Jessica L Roberts, Nafees Ud Din, Nicola Totton, Joanna M Charles, Zoe Hoare, Rhiannon T Edwards
Background: Health economic evaluations rely on the accurate measurement of health service resource use in order to calculate costs. These are usually measured with patient completed questionnaires using instruments such as the Client Service Receipt Inventory (CSRI). These rely on participants' recall and can be burdensome to complete. Health service activity data are routinely captured by electronic databases.The aim was to test methods for obtaining these data and compare with those data collected using the CSRI, within a feasibility study of an enhanced rehabilitation intervention following hip fracture (Fracture in the Elderly Multidisciplinary Rehabilitation: FEMuR)...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29750119/peer-mentoring-for-eating-disorders-evaluation-of-a-pilot-program
#2
Jennifer Beveridge, Andrea Phillipou, Kelly Edwards, Alice Hobday, Krissy Hilton, Cathy Wyett, Anna Saw, Georgia Graham, David Castle, Leah Brennan, Philippa Harrison, Rebecca de Gier, Narelle Warren, Freya Hanly, Benjamin Torrens-Witherow, J Richard Newton
Background: Eating disorders are serious psychiatric illnesses that are often associated with poor quality of life and low long-term recovery rates. Peer mentor programs have been found to improve psychiatric symptoms and quality of life in other mental illnesses, and a small number of studies have suggested that eating disorder patients may benefit from such programs. The aim of this study is to assess the efficacy of a peer mentor program for individuals with eating disorders in terms of improving symptomatology and quality of life...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29736256/a-mixed-methods-evaluation-of-yoga-as-a-fall-prevention-strategy-for-older-people-in-india
#3
Lisa Keay, Devarsetty Praveen, Abdul Salam, K V Rajasekhar, Anne Tiedemann, Vimala Thomas, Jagnoor Jagnoor, Cathie Sherrington, Rebecca Q Ivers
Background: Falls are an emerging public health issue in India, with the impact set to rise as the population ages. We sought to evaluate the acceptability, feasibility and likely impact of a yoga-based program aimed at improving balance and mobility for older residents in urban India. Methods: Fifty local residents aged 60 years and older were recruited from urban Hyderabad, Andhra Pradesh. They were invited to attend a 1-h yoga class, twice weekly for 3 months...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29721332/a-pilot-randomised-double-blind-controlled-trial-of-the-efficacy-of-purified-fatty-acids-for-the-treatment-of-women-with-endometriosis-associated-pain-purfect-study-protocol
#4
Ibtisam M Abokhrais, Philippa T K Saunders, Fiona C Denison, Ann Doust, Linda Williams, Andrew W Horne
Background: Endometriosis affects 6-10% of women and is associated with debilitating pelvic pain. It costs the UK > £2.8 billion per year in loss of productivity. Endometriosis can be managed by surgical excision or medically by ovarian suppression. However, ~ 75% symptoms recur after surgery and available medical treatments have undesirable side effects and are contraceptive. Omega-3 purified fatty acids (PUFA) have been shown in animal models to reduce factors that are thought to lead to endometriosis-associated pain, have minimal side effects, and no effects on fertility...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29721331/the-development-of-an-occupational-therapy-intervention-for-adults-with-a-diagnosed-psychotic-disorder-following-discharge-from-hospital
#5
Mary Birken, Claire Henderson, Mike Slade
Background: A deterioration in mental health and admission to an acute mental health unit can result in skill loss and decreased participation in daily life. Furthermore, discharge from hospital is associated with high risks of social isolation and suicide. This intervention development study aims to describe the rationale, methods and processes of developing an intervention for adults with a diagnosed psychotic disorder following discharge from hospital. The intervention aims to increase participation in self-care and leisure, wellbeing and quality of life and reduce crisis service use...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29713494/developing-and-feasibility-testing-of-data-collection-methods-for-an-economic-evaluation-of-a-supported-selfmanagement-programme-for-adults-with-a-learning-disability-and-type-2-diabetes
#6
John L O'Dwyer, Amy M Russell, Louise D Bryant, Rebecca E A Walwyn, Alexandra M Wright-Hughes, Elizabeth H Graham, Judy M Wright, Shaista Meer, Jacqueline Birtwistle, Amanda J Farrin, Allan O House, Claire T Hulme
Background: The challenges of conducting research with hard to reach vulnerable groups are particularly pertinent for people with learning disabilities. Data collection methods for previous cost and cost-effectiveness analyses of health and social care interventions targeting people with learning disabilities have relied on health care/health insurance records or data collection forms completed by the service provider rather than by people with learning disabilities themselves. This paper reports on the development and testing of data collection methods for an economic evaluation within a randomised controlled trial (RCT) for a supported self-management programme for people with mild/moderate learning disabilities and type 2 diabetes...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29713493/prophylaxis-of-acute-respiratory-infections-via-improving-the-immune-system-in-late-preterm-newborns-with-e-coli-strain-nissle-1917-a-controlled-pilot-trial
#7
Mykola L Aryayev, Liudmyla I Senkivska, Nataliya K Bredeleva, Irina V Talashova
Background: Acute respiratory infections (ARIs), caused by the high level of immaturity of the immune system, are a major cause of morbidity in preterm newborns. The probiotic Escherichia coli strain Nissle 1917 (EcN) is well known for its immuno-modulatory properties and may therefore enhance the immune competence. Thus, EcN administration may provide a promising possibility to decrease the risk of ARIs in this vulnerable group of children. However, clinical data supporting or refuting this hypothesis are, to our knowledge, not available...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29686884/exercise-therapy-patient-education-and-patellar-taping-in-the-treatment-of-adolescents-with-patellofemoral-pain-a-prospective-pilot-study-with-6-months-follow-up
#8
Michael S Rathleff, Camilla R Rathleff, Sinead Holden, Kristian Thorborg, Jens L Olesen
Background: Patellofemoral pain (PFP) is the most common knee condition among adolescents, with a prevalence of 6-7% resulting in reduced function and quality of life. Exercise therapy is recommended for treating PFP, but has only been tested in older adolescents (15-19 years). This pilot study aimed to investigate the adherence to, and clinical effects of, exercise and patient education in young adolescents (12-16 years), with PFP. Methods: Twenty adolescents (16 females) with PFP were recruited from a population-based cohort to undergo a 3-month multimodal intervention...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29686883/double-blind-acupuncture-needles-a-multi-needle-multi-session-randomized-feasibility-study
#9
Judith M Schlaeger, Nobuari Takakura, Hiroyoshi Yajima, Miho Takayama, Alana D Steffen, Elizabeth M Gabzdyl, Robyn A Nisi, Kathleen McGowan Gruber, Jason M Bussell, Diana J Wilkie
Background: Efficacy of acupuncture is difficult to demonstrate without a feasible double-blind milieu. Double-blind acupuncture needles have been validated in single session protocols with one or two needles but not been tested in a protocol requiring many needles and repeated sessions. Methods: We determined the feasibility of a 13-needle, 10-session study protocol. Feasibility focused on (1) enrolling and retaining participants; (2) two acupuncturists accurately implementing a double-blind, multi-needle, multi-session protocol; (3) participants completing measures; and (4) protocol acceptability to participants...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29636984/thiazide-diuretic-caused-hyponatremia-in-the-elderly-hypertensive-will-a-bottle-of-nepro-a-day-keep-hyponatremia-and-the-doctor-away-study-protocol-for-a-proof-of-concept-feasibility-trial
#10
Marcel Ruzicka, Brendan McCormick, Peter Magner, Tim Ramsay, Cedric Edwards, Ann Bugeja, Swapnil Hiremath
Background: Hypertension is the most common modifiable risk factor for cardiovascular disease, with an increasing prevalence with age, but with easily available medications to control it. Adverse effects of these medications do limit their use, in particular hyponatremia due to thiazide and thiazide-like diuretics. This is more common in the elderly patients due to a combination of inadequate protein intake and impaired urinary dilution capability, made worse by additional thiazide use...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29636983/a-6-week-hip-muscle-strengthening-and-lumbopelvic-hip-core-stabilization-program-to-improve-pain-function-and-quality-of-life-in-persons-with-patellofemoral-osteoarthritis-a-feasibility-pilot-study
#11
Lisa T Hoglund, Laura Pontiggia, John D Kelly
Background: Patellofemoral joint (PFJ) osteoarthritis (OA) is prevalent in middle-aged and older adults. Despite this, there are minimal studies which have examined conservative interventions for PFJ OA. Weakness of proximal lower extremity muscles is associated with PFJ OA. It is unknown if a hip muscle strengthening and lumbopelvic-hip core stabilization program will improve symptoms and function in persons with PFJ OA. This study examined the feasibility and impact of a 6-week hip muscle strengthening and core stabilization program on pain, symptoms, physical performance, peak muscle torques, and quality of life in persons with PFJ OA...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29619242/adolescents-and-health-related-behaviour-using-a-framework-to-develop-interventions-to-support-positive-behaviours
#12
Jan Pringle, Lawrence Doi, Divya Jindal-Snape, Ruth Jepson, John McAteer
Background: Experimentation is a natural part of adolescent maturation. In conjunction with increased exposure to behaviours such as alcohol or substance use, and the potentially intensified influence of peer groups, unhealthy behaviour patterns may develop as part of this experimentation. However, the adolescent years also provide considerable opportunity for behaviour to be shaped in positive ways that may improve immediate and longer term health outcomes. A systematic review carried out by the authors concluded that physiological changes during adolescence need to be considered when designing or implementing interventions, due to their influence on health behaviours...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29610675/habit-an-early-phase-study-to-explore-an-oral-health-intervention-delivered-by-health-visitors-to-parents-with-young-children-aged-9-12-months-study-protocol
#13
Ieva Eskyte, Kara Gray-Burrows, Jenny Owen, Bianca Sykes-Muskett, Tim Zoltie, Susanne Gill, Victoria Smith, Rosemary McEachan, Zoe Marshman, Robert West, Sue Pavitt, Peter Day
Background: Parental supervised brushing (PSB) when initiated in infancy can lead to long-term protective home-based oral health habits thereby reducing the risk of dental caries. However, PSB is a complex behaviour with many barriers reported by parents hindering its effective implementation. Within the UK, oral health advice is delivered universally to parents by health visitors and their wider teams when children are aged between 9 and 12 months. Nevertheless, there is no standardised intervention or training upon which health visitors can base this advice, and they often lack the specialised knowledge needed to help parents overcome barriers to performing PSB and limiting sugary foods and drinks...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29588862/invasive-urodynamic-testing-prior-to-surgical-treatment-for-stress-urinary-incontinence-in-women-cost-effectiveness-and-value-of-information-analyses-in-the-context-of-a-mixed-methods-feasibility-study
#14
Tara Homer, Jing Shen, Luke Vale, Elaine McColl, Douglas G Tincello, Paul Hilton
Background: INVESTIGATE-I (INVasive Evaluation before Surgical Treatment of Incontinence Gives Added Therapeutic Effect?) was a mixed methods study to assess the feasibility of a future randomised controlled trial of invasive urodynamic testing (IUT) prior to surgery for stress urinary incontinence (SUI) in women. Here we report one of the study's five components, with the specific objectives of (i) exploring the cost-effectiveness of IUT compared with clinical assessment plus non-invasive tests (henceforth described as 'IUT' and 'no IUT' respectively) in women with SUI or stress-predominant mixed urinary incontinence (MUI) prior to surgery, and (ii) determining the expected net gain (ENG) from additional research...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29588861/standing-practice-in-rehabilitation-early-after-stroke-spires-a-functional-standing-frame-programme-prolonged-standing-and-repeated-sit-to-stand-to-improve-function-and-quality-of-life-and-reduce-neuromuscular-impairment-in-people-with-severe-sub-acute-stroke
#15
Angie Logan, Jennifer Freeman, Bridie Kent, Jillian Pooler, Siobhan Creanor, Jane Vickery, Doyo Enki, Andrew Barton, Jonathan Marsden
Background: The most common physical deficit caused by a stroke is muscle weakness which limits a person's mobility. Mobility encompasses activities necessary for daily functioning: getting in and out bed, on/off toilet, sitting, standing and walking. These activities are significantly affected in people with severe stroke who typically spend most of their time in bed or a chair and are immobile. Immobility is primarily caused by neurological damage but exacerbated by secondary changes in musculoskeletal and cardiorespiratory systems...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29588860/technology-based-functional-assessment-in-early-childhood-intervention-a-pilot-study
#16
Mary A Khetani, Beth M McManus, Kristen Arestad, Zachary Richardson, Renee Charlifue-Smith, Cordelia Rosenberg, Briana Rigau
Background: Electronic patient-reported outcomes (e-PROs) may provide valid and feasible options for obtaining family input on their child's functioning for care planning and outcome monitoring, but they have not been adopted into early intervention (EI). The purpose of this pilot study was to evaluate the feasibility of implementing technology-based functional assessment into EI practice and to examine child, family, service, and environmental correlates of caregiver-reported child functioning in the home...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29564147/prehospital-recognition-and-antibiotics-for-999-patients-with-sepsis-protocol-for-a-feasibility-study
#17
Chris Moore, Jenna Bulger, Matt Morgan, Timothy Driscoll, Alison Porter, Saiful Islam, Mike Smyth, Gavin Perkins, Bernadette Sewell, Timothy Rainer, Prabath Nanayakkara, Chukwudi Okolie, Susan Allen, Greg Fegan, Jan Davies, Theresa Foster, Nick Francis, Fang Gao Smith, Gemma Ellis, Tracy Shanahan, Robin Howe, Helen Snooks
Background: Sepsis is a common condition which kills between 36,000 and 64,000 people every year in the UK. Early recognition and management of sepsis has been shown to reduce mortality and improve the health and well-being of people with sepsis. Paramedics frequently come into contact with patients with sepsis and are well placed to provide early diagnosis and treatment.We aim to determine the feasibility of undertaking a fully powered randomised controlled trial (RCT) to test the clinical and cost-effectiveness of paramedics obtaining blood cultures from and administering IV antibiotics to patients with sepsis, so we can make a decision about whether to proceed to a fully powered randomised controlled trial, which will answer questions regarding safety and effectiveness for patients and benefit to the National Health Service (NHS)...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29556414/exoskeleton-assisted-gait-training-to-improve-gait-in-individuals-with-spinal-cord-injury-a-pilot-randomized-study
#18
Shuo-Hsiu Chang, Taimoor Afzal, Jeffrey Berliner, Gerard E Francisco
Background: Robotic wearable exoskeletons have been utilized as a gait training device in persons with spinal cord injury. This pilot study investigated the feasibility of offering exoskeleton-assisted gait training (EGT) on gait in individuals with incomplete spinal cord injury (iSCI) in preparation for a phase III RCT. The objective was to assess treatment reliability and potential efficacy of EGT and conventional physical therapy (CPT). Methods: Forty-four individuals were screened, and 13 were eligible to participate in the study...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29541480/enhancing-condom-use-experiences-among-young-men-to-improve-correct-and-consistent-condom-use-feasibility-of-a-home-based-intervention-strategy-his-uk
#19
Nicole Stone, Cynthia Graham, Sydney Anstee, Katherine Brown, Katie Newby, Roger Ingham
Background: Condoms remain the main protection against sexually transmitted infections (STIs) when used correctly and consistently. Yet, there are many reported barriers to their use such as negative attitudes, reduced sexual pleasure, fit-and-feel problems and erection difficulties. The UK home-based intervention strategy (HIS-UK) is a behaviour change condom promotion intervention for use among young men (aged 16-25 years) designed to increase condom use by enhancing enjoyment of condom-protected intercourse...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29511570/protocol-for-the-star-sheffield-treatments-for-adhd-project-an-internal-pilot-study-assessing-the-feasibility-of-the-trials-within-cohorts-twics-design-to-test-the-effectiveness-of-interventions-for-children-with-adhd
#20
Philippa Fibert, Clare Relton, Tessa Peasgood, David Daley
Background: Attention deficit hyperactivity disorder (ADHD) is a common and growing problem and a leading cause of child referrals to Child and Adult Mental Health Services (CAMHS). It is a drain on resources across nationally funded support agencies and associated with negative outcomes such as early criminality, school disruption and antisocial behaviour. Mainstream interventions (pharmacological and behavioural) demonstrate effectiveness whilst implemented, but are costly, often have unwanted side effects and do not appear to be affecting long-term outcomes...
2018: Pilot and Feasibility Studies
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