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Journal of Experimental Orthopaedics

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https://www.readbyqxmd.com/read/28646430/mechanical-strength-assessment-of-a-drilled-hole-in-the-contralateral-cortex-at-the-end-of-the-open-wedge-for-high-tibial-osteotomy
#1
Arnaud Diffo Kaze, Stefan Maas, Alexander Hoffmann, Dietrich Pape
BACKGROUND: This study aimed to investigate, by means of finite element analysis, the effect of a drill hole at the end of a horizontal osteotomy to reduce the risk of lateral cortex fracture while performing an opening wedge high tibial osteotomy (OWHTO). The question was whether drilling a hole relieves stress and increases the maximum correction angle without fracture of the lateral cortex depending on the ductility of the cortical bone. METHODS: Two different types of osteotomy cuts were considered; one with a drill hole (diameter 5 mm) and the other without the hole...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28634835/impact-of-mechanical-stimulation-on-the-chondrogenic-processes-in-human-bone-marrow-aspirates-modified-to-overexpress-sox9-via-raav-vectors
#2
Jagadeesh K Venkatesan, Janina Frisch, Ana Rey-Rico, Gertrud Schmitt, Henning Madry, Magali Cucchiarini
BACKGROUND: Evaluation of gene-based approaches to target human bone marrow aspirates in conditions of mechanical stimulation that aim at reproducing the natural joint environment may allow to develop improved treatments for articular cartilage injuries. In the present study, we investigated the potential of rAAV-mediated sox9 gene transfer to enhance the chondrogenic differentiation processes in human bone marrow aspirates under established hydrodynamic conditions compared with the more commonly employed static culture conditions...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28608283/geometric-morphometric-analysis-reveals-age-related-differences-in-the-distal-femur-of-europeans
#3
Etienne Cavaignac, Frederic Savall, Elodie Chantalat, Marie Faruch, Nicolas Reina, Philippe Chiron, Norbert Telmon
BACKGROUND: Few studies have looked into age-related variations in femur shape. We hypothesized that three-dimensional (3D) geometric morphometric analysis of the distal femur would reveal age-related differences. The purpose of this study was to show that differences in distal femur shape related to age could be identified, visualized, and quantified using three-dimensional (3D) geometric morphometric analysis. METHODS: Geometric morphometric analysis was carried out on CT scans of the distal femur of 256 subjects living in the south of France...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28585023/dynamic-radiostereometric-analysis-for-evaluation-of-hip-joint-pathomechanics
#4
Lars Hansen, Sepp de Raedt, Peter Bo Jørgensen, Bjarne Mygind-Klavsen, Bart Kaptein, Maiken Stilling
BACKGROUND: Dynamic RSA (dRSA) enables non-invasive 3D motion-tracking of bones and may be used to evaluate in-vivo hip joint kinematics including hip pathomechanics such as femoroacetabular impingement (FAI) and the biomechanical effects of arthroscopic cheilectomy and -rim trimming (ACH). The study aim was to evaluate the kinematic changes in the hip joint after ACH. METHODS: Seven non-FAI affected human cadaveric hips were CT-scanned and CT-bone models were created...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28577187/autofluorescence-imaging-for-improved-visualization-of-joint-structures-during-arthroscopic-surgery
#5
Duy Tan Nguyen, Pepijn van Horssen, Hans Derriks, Martijn van de Giessen, Ton van Leeuwen
BACKGROUND: The purpose of our study is to develop the arthroscopic autofluorescence imaging (AFI) system to improve the visualization during arthroscopic surgery by real-time enhancing the contrast between joint structures with autofluorescence imaging. Its validity was evaluated around the arthroscopic anterior cruciate ligament (ACL) reconstruction, specifically improving the contrast between the femoral insertion site and its background. The feasibility of the AFI system was validated with bovine and human knees...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28560707/current-trends-in-tendinopathy-consensus-of-the-esska-basic-science-committee-part-i-biology-biomechanics-anatomy-and-an-exercise-based-approach
#6
REVIEW
F Abat, H Alfredson, M Cucchiarini, H Madry, A Marmotti, C Mouton, J M Oliveira, H Pereira, G M Peretti, D Romero-Rodriguez, C Spang, J Stephen, C J A van Bergen, L de Girolamo
Chronic tendinopathies represent a major problem in the clinical practice of sports orthopaedic surgeons, sports doctors and other health professionals involved in the treatment of athletes and patients that perform repetitive actions. The lack of consensus relative to the diagnostic tools and treatment modalities represents a management dilemma for these professionals. With this review, the purpose of the ESSKA Basic Science Committee is to establish guidelines for understanding, diagnosing and treating this complex pathology...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28534321/does-anatomic-single-bundle-acl-reconstruction-using-hamstring-autograft-produce-anterolateral-meniscal-root-tearing
#7
Sebastián Irarrázaval, Angel Masferrer-Pino, Maximiliano Ibañez, Tamer M A Shehata, María Naharro, Joan C Monllau
BACKGROUND: To determine if tibial tunnel reaming during anatomic single-bundle anterior cruciate ligament (ACL) reconstruction using hamstring autograft can result in anterolateral meniscal root injury, as diagnosed by magnetic resonance imaging (MRI). METHODS: A case series of 104 primary anatomic single-bundle ACL reconstructions using hamstring autograft was retrospectively reviewed. Pre- and post-operative (>1 year) MRIs were radiologically evaluated for each patient, with a lateral meniscus extrusion > 3 mm at the level of the medial collateral ligament midportion on a coronal MRI, to establish anterolateral meniscal root injury...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28500483/the-effect-of-repetitive-flexion-and-extension-fatigue-loading-on-the-young-porcine-lumbar-spine-a-feasibility-study-of-mri-and-histological-analyses
#8
Olof Thoreson, Lars Ekström, Hans-Arne Hansson, Carl Todd, Wisam Witwit, Anna Swärd Aminoff, Pall Jonasson, Adad Baranto
BACKGROUND: The biomechanical mechanisms of failure of FSUs have been studied but the correlation of repetitive flexion and extension loadings to the initial phase of fatigue in young FSUs are still not known. The purpose of the study was to examine the fatigue results of low magnitude repetitive flexion and extension loading on porcine lumbar Functional Spinal Units (FSUs) with Magnetic Resonance Imaging (MRI) and histology. METHODS: Eight FSUs were subject to repetitive pivot flexion and eight to extension loading by a protocol of 20 000 cycles at 1 Hz with a load of 700 N...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28488256/the-rate-of-publication-of-free-papers-at-the-2008-and-2010-european-society-of-sports-traumatology-knee-surgery-and-arthroscopy-congresses
#9
Jeffrey Kay, Muzammil Memon, Joelle Rogozinsky, Darren de Sa, Nicole Simunovic, Romain Seil, Jon Karlsson, Olufemi Rolland Ayeni
BACKGROUND: The purpose of this study was to evaluate the frequency with which free papers presented at the 2008 and 2010 European Society of Sports Traumatology Knee Surgery and Arthroscopy (ESSKA) congress were ultimately published in peer-reviewed journals. Moreover, this study evaluated whether any correlations exist between the level of evidence of the free papers and their frequency of publication or the impact factor of the journals in which they are published. METHODS: Free papers presented at the 2008 and 2010 ESSKA congresses were included for assessment...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28470629/hyaluronan-thiomer-gel-matrix-mediated-healing-of-articular-cartilage-defects-in-new-zealand-white-rabbits-a-pilot-study
#10
Christoph Bauer, Vivek Jeyakumar, Eugenia Niculescu-Morzsa, Daniela Kern, Stefan Nehrer
BACKGROUND: Articular cartilage defects are limited to their regenerative potential in human adults. Our current study evaluates tissue regeneration in a surgically induced empty defect site with hyaluronan thiomer as a provisional scaffold in a gel/matrix combination without cells on rabbit models to restore tissue formation. METHODS: An osteochondral defect of 4 mm in diameter and 5 mm in depth was induced by mechanical drilling in the femoral center of the trochlea in 18 New Zealand White rabbits...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28466436/three-dimensional-geometric-morphometric-analysis-reveals-ethnic-dimorphism-in-the-shape-of-the-femur
#11
Etienne Cavaignac, Ke Li, Marie Faruch, Frederic Savall, Philippe Chiron, W Huang, Norbert Telmon
BACKGROUND: Ethnic dimorphism in the distal femur has never been studied in a three-dimensional analysis focused on shape instead of size. Yet, this dimorphism has direct implications in orthopedic surgery and in anthropology. The goal of this study was to show that differences in distal femur shape related to ethnic dimorphism could be identified, visualized, and quantified using 3D geometric morphometric analysis. METHODS: CT scans of the distal femur were taken from 482 patients who were free of any bone-related pathology: 240 patients were European (E) and 242 were Asian (A)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28425031/the-cytokine-expression-in-synovial-membrane-and-the-relationship-with-pain-and-pathological-findings-at-hip-arthroscopy
#12
Kensuke Fukushima, Gen Inoue, Hisako Fujimaki, Kentaro Uchida, Masayuki Miyagi, Naoshige Nagura, Katsufumi Uchiyama, Naonobu Takahira, Masashi Takaso
BACKGROUND: Synovial membrane inflammation is the most common finding presenting during hip arthroscopy, and may play a role in hip pain. We sought to determine the relationships between synovial cytokine levels, hip pain, and arthroscopic findings of the hip joint. METHODS: We prospectively included 33 patients who underwent arthroscopic hip surgery (34 hips). For all patients, radiographs and severity of pain were evaluated preoperatively. During arthroscopy, we classified the chondral injury and synovitis, noted the incidence of labral tear and its instability, and a sample of the synovial membrane was harvested for quantitative PCR to determine levels of TNFα, IL1β, IL6, ADAMTS4, MMP1, and MMP3...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28417444/a-retinaculum-sparing-surgical-approach-preserves-porcine-stifle-joint-cartilage-in-an-experimental-animal-model-of-cartilage-repair
#13
Marcelo B Bonadio, James M Friedman, Mackenzie L Sennett, Robert L Mauck, George R Dodge, Henning Madry
BACKGROUND: This study compares a traditional parapatellar retinaculum-sacrificing arthrotomy to a retinaculum-sparing arthrotomy in a porcine stifle joint as a cartilage repair model. FINDINGS: Surgical exposure of the femoral trochlea of ten Yucatan pigs stifle joint was performed using either a traditional medial parapatellar approach with retinaculum incision and luxation of the patella (n = 5) or a minimally invasive (MIS) approach which spared the patellar retinaculum (n = 5)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28361277/the-effect-of-a-dynamic-pcl-brace-on-patellofemoral-compartment-pressures-in-pcl-and-pcl-plc-deficient-knees
#14
Tyler Welch, Thomas Keller, Ruben Maldonado, Melodie Metzger, Karen Mohr, Ronald Kvitne
BACKGROUND: The natural history of posterior cruciate ligament (PCL) deficiency includes the development of arthrosis in the patellofemoral joint (PFJ). The purpose of this biomechanical study was to evaluate the hypothesis that dynamic bracing reduces PFJ pressures in PCL- and combined PCL/posterolateral corner (PLC)-deficient knees. STUDY DESIGN: Controlled Laboratory Study. METHODS: Eight fresh frozen cadaveric knees with intact cruciate and collateral ligaments were included...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28332149/biomechanical-cadaveric-comparison-of-patellar-ligament-suture-protected-by-a-steel-cable-versus-a-synthetic-cable
#15
P Bouget, C Breque, J S Beranger, J P Faure, F Khiami, T Vendeuvre
BACKGROUND: Purpose and hypothesis: Patellar ligament rupture is a rare disabling pathology requiring a surgical ligament suture protected by a frame. The gold standard is the steel cable, but its rigidity and the necessity of a surgical re-intervention for its removal render it unsatisfactory. The objective of this paper is to quantify the mechanical protection provided by the terylene® in comparison with steel. METHODS: Twenty-four knees of 12 fresh frozen cadaveric subjects were divided into 2 homogeneous groups (terylene and steel) of 12 knees (mean age = 69...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28244027/different-culture-conditions-affect-the-growth-of-human-tendon-stem-progenitor-cells-tspcs-within-a-mixed-tendon-cells-tcs-population
#16
M Viganò, C Perucca Orfei, A Colombini, D Stanco, P Randelli, V Sansone, L de Girolamo
BACKGROUND: Tendon resident cells (TCs) are a mixed population made of terminally differentiated tenocytes and tendon stem/progenitor cells (TSPCs). Since the enrichment of progenitors proportion could enhance the effectiveness of treatments based on these cell populations, the interest on the effect of culture conditions on the TSPCs is growing. In this study the clonal selection and the culture in presence or absence of basic fibroblast growth factor (bFGF) were used to assess their influences on the stemness properties and phenotype specific features of tendon cells...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28229430/differences-in-biomarkers-of-cartilage-matrix-turnover-and-their-changes-over-2%C3%A2-years-in-adolescent-and-adult-volleyball-athletes
#17
Heide Boeth, Aoife MacMahon, A Robin Poole, Frank Buttgereit, Patrik Önnerfjord, Pilar Lorenzo, Cecilia Klint, Anna Pramhed, Georg N Duda
BACKGROUND: This study aimed the feasibility to assess longitudinal changes in biomarkers of cartilage turnover and to determine their relationship with patient-rated outcomes over 2 years in volleyball athletes. METHODS: Thirty-seven athletes were studied: 18 adolescents (age 15.9 ± 0.64 years) in a 2-year intensive volleyball training program and 19 adult recreational volleyball players (age 46.5 ± 4.9 years). Blood and serum samples were taken at baseline (BL) and 2-year follow-up (FU)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28224374/mri-findings-of-knee-abnormalities-in-adolescent-and-adult-volleyball-players
#18
Heide Boeth, Aoife MacMahon, Felix Eckstein, Gerd Diederichs, Arne Schlausch, Wolfgang Wirth, Georg N Duda
BACKGROUND: To longitudinally and cross-sectionally evaluate knee abnormalities by sex and age in adolescent and adult volleyball athletes over 2 years using magnetic resonance imaging (MRI). METHODS: Thirty-six high-level volleyball athletes (18 adolescents: 56% female, mean age 16.0 ± 0.8 years; and 18 adults: 50% female, mean age 46.8 ± 5.1 years) were imaged by MRI at BL and at 2-year follow-up (FU). Prevalence and severity of cartilage lesions, subarticular bone marrow lesions (BMLs), subarticular cysts, osteophytes, and ligament and meniscus integrity were evaluated by sex and by age cohort (adolescents and adults) using the whole-organ MRI score (WORMS)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28176273/the-haematoma-and-its-role-in-bone-healing
#19
REVIEW
H Schell, G N Duda, A Peters, S Tsitsilonis, K A Johnson, K Schmidt-Bleek
Fracture treatment is an old endeavour intended to promote bone healing and to also enable early loading and regain of function in the injured limb. However, in today's clinical routine the healing potential of the initial fracture haematoma is still not fully recognized. The Arbeitsgemeinschaft für Osteosynthesefragen (AO) formed in Switzerland in 1956 formulated four AO principles of fracture treatment which are still valid today. Fracture treatment strategies have continued to evolve further, as for example the relatively new concept of minimally invasive plate osteosynthesis (MIPO)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28176272/effects-of-combined-raav-mediated-tgf-%C3%AE-and-sox9-gene-transfer-and-overexpression-on-the-metabolic-and-chondrogenic-activities-in-human-bone-marrow-aspirates
#20
Ke Tao, Ana Rey-Rico, Janina Frisch, Jagadeesh Kumar Venkatesan, Gertrud Schmitt, Henning Madry, Jianhao Lin, Magali Cucchiarini
BACKGROUND: Transplantation of genetically modified bone marrow concentrates is an attractive approach to conveniently activate the chondrogenic differentiation processes as a means to improve the intrinsic repair capacities of damaged articular cartilage. METHODS: Human bone marrow aspirates were co-transduced with recombinant adeno-associated virus (rAAV) vectors to overexpress the pleiotropic transformation growth factor beta (TGF-β) and the cartilage-specific transcription factor sox9 as a means to enhance the chondroreparative processes in conditions of specific lineage differentiation...
December 2017: Journal of Experimental Orthopaedics
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