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Journal of Experimental Orthopaedics

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https://www.readbyqxmd.com/read/27854082/randomized-controlled-trial-comparing-the-effectiveness-of-the-ultrasound-guided-galvanic-electrolysis-technique-usget-versus-conventional-electro-physiotherapeutic-treatment-on-patellar-tendinopathy
#1
F Abat, J L Sánchez-Sánchez, A M Martín-Nogueras, J I Calvo-Arenillas, J Yajeya, R Méndez-Sánchez, J C Monllau, P E Gelber
BACKGROUND: Patellar tendinopathy has a high prevalence rate among athletes. Different therapeutic options can be found in the current literature, but none of them has been clearly established as the gold standard. The purpose of this study is to compare, in a randomized controlled trial, the clinical efficacy of eccentric exercise combined with either an ultrasound-guided galvanic electrolysis technique (USGET) or conventional electrophysiotherapy to treat patellar tendinopathy. METHODS: Sixty patients diagnosed with patellar tendinopathy were randomized into two groups...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27813021/bone-marrow-aspirate-concentrate-for-the-treatment-of-osteochondral-lesions-of-the-talus-a-systematic-review-of-outcomes
#2
REVIEW
Jorge Chahla, Mark E Cinque, Jason M Shon, Daniel J Liechti, Lauren M Matheny, Robert F LaPrade, Thomas O Clanton
BACKGROUND: The goal of this perform a systematic review on the outcomes of bone marrow aspirate concentrate (BMAC) for the treatment of chondral defects and osteoarthritis (OA) of the talus. RESULTS: The systematic search performed identified 47 studies after duplicates were removed. After inclusion criteria were applied four studies were considered for insightful analysis for the treatment of focal chondral defects in the foot and ankle with the use of BMAC. Three studies were retrospective and one study was prospective in nature...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27813020/new-insight-in-the-architecture-of-the-quadriceps-tendon
#3
Karl Grob, Mirjana Manestar, Luis Filgueira, Timothy Ackland, Helen Gilbey, Markus S Kuster
BACKGROUND: Published data regarding the structure of the quadriceps tendon are diverse. Dissection of the quadriceps muscle group revealed that beside the rectus femoris, vastus lateralis, vastus intermedius and vastus medialis a fifth muscle component- named the tensor vastus intermedius consistently fused into quadriceps tendon. It can be hypothesized that all these elements of the extensor apparatus of the knee joint must also be represented in the quadriceps tendon. This study investigated the multi-layered quadriceps tendon with special emphasis on all components of the quadriceps muscle group including the newly discovered tensor vastus intermedius...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27813019/knee-donor-site-morbidity-after-mosaicplasty-a-systematic-review
#4
REVIEW
Renato Andrade, Sebastiano Vasta, Rogério Pereira, Hélder Pereira, Rocco Papalia, Mustafa Karahan, J Miguel Oliveira, Rui L Reis, João Espregueira-Mendes
BACKGROUND: Mosaicplasty has been associated with good short- to long-term results. Nevertheless, the osteochondral harvesting is restricted to the donor-site area available and it may lead to significant donor-site morbidity. PURPOSE: Provide an overview of donor-site morbidity associated with harvesting of osteochondral plugs from the knee joint in mosaicplasty procedure. METHODS: Comprehensive search using Pubmed, Cochrane Library, SPORTDiscus and CINAHL databases was carried out through 10(th) October of 2016...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27807812/inflammatory-cytokine-levels-in-synovial-fluid-3-4%C3%A2-days-postoperatively-and-its-correlation-with-early-phase-functional-recovery-after-anterior-cruciate-ligament-reconstruction-a-cohort-study
#5
Makiko Inoue, Takeshi Muneta, Miyoko Ojima, Kaori Nakamura, Hideyuki Koga, Ichiro Sekiya, Mutsumi Okazaki, Kunikazu Tsuji
BACKGROUND: Synovial fluid was collected prior to and at 3 to 4 days after ACL reconstruction to investigate the correlation between inflammatory cytokine levels in the acute phase after surgery and physical functional recovery at 3 months postoperatively. METHODS:  For this purpose, 79 patients with ACL reconstruction using semitendinosus tendons were included in the study. Median days from injury to surgery were 80 days (13-291 days). Synovial fluid was obtained just before surgery and at 3 to 4 days after surgery...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27783350/knee-joint-kinematics-with-dynamic-augmentation-of-primary-anterior-cruciate-ligament-repair-a-biomechanical-study
#6
Janosch Häberli, Philipp Henle, Yves P Acklin, Ivan Zderic, Boyko Gueorguiev
BACKGROUND: Dynamic augmentation of anterior cruciate ligament tears seems to reduce anteroposterior knee translation close to the pre-injury level. The aim of the present study is to biomechanically investigate the course of translation during a simulated early post-operative phase. It is hypothesized that anteroposterior translation is maintained at the immediate post-operative level over a simulated rehabilitation period of 50'000 gait cycles. METHODS: Eight fresh-frozen human cadaveric knee joints from donors with a mean age of 35...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27734283/the-cross-sectional-shape-of-the-fourfold-semitendinosus-tendon-is-oval-not-round
#7
Takeshi Oshima, Junsuke Nakase, Hitoaki Numata, Yasushi Takata, Hiroyuki Tsuchiya
BACKGROUND: The looped side of the semitendinosus tendon (ST) graft (i.e., the side inserted into the femoral tunnel during anterior cruciate ligament reconstruction) appears to be oval rather than round. The purpose of this study was to investigate the cross section of the fourfold semitendinosus tendon graft and, more specifically, the differences in pressure exerted by a rounded rectangular tunnel versus a round femoral tunnel. METHODS: Seven STs were harvested from cadaveric knees and a fourfold ST graft was made...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27730595/three-dimensional-kinematic-and-kinetic-analysis-of-knee-rotational-stability-in-acl-deficient-patients-during-walking-running-and-pivoting
#8
Marie Bagger Bohn, Annemette Krintel Petersen, Dennis Brandborg Nielsen, Henrik Sørensen, Martin Lind
BACKGROUND: Anterior cruciate ligament (ACL) deficiency leads to altered stability of the knee. The purpose of this study was to compare the dynamic, rotational stability of the knee, expressed as rotational stiffness, between anterior cruciate ligament-deficient (ACLD) knees, their contralateral intact knees (ACLI) and a knee healthy control group during walking, running and 90° pivoting. We hypothesized a larger tibial internal rotation, a smaller knee joint external moment and a lower rotational stiffness in the ACLD group compared to the ACLI and the control group...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27730594/erratum-to-imaging-the-implant-soft-tissue-interactions-in-total-knee-arthroplasty
#9
Michel P Bonnin, Tom Van Hoof, Arnoud De Kok, Matthias Verstraete, Catherine Van der Straeten, Mo Saffarini, Jan Victor
No abstract text is available yet for this article.
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27714703/sustained-delivery-of-recombinant-human-bone-morphogenetic-protein-2-from-perlecan-domain-i-functionalized-electrospun-poly-%C3%AE%C2%B5-caprolactone-scaffolds-for-bone-regeneration
#10
Yu-Chieh Chiu, Eliza L Fong, Brian J Grindel, Fred K Kasper, Daniel A Harrington, Mary C Farach-Carson
BACKGROUND: Biomaterial scaffolds that deliver growth factors such as recombinant human bone morphogenetic proteins-2 (rhBMP-2) have improved clinical bone tissue engineering by enhancing bone tissue regeneration. This approach could be further improved if the controlled delivery of bioactive rhBMP-2 were sustained throughout the duration of osteogenesis from fibrous scaffolds that provide control over dose and bioactivity of rhBMP-2. In nature, heparan sulfate attached to core proteoglycans serves as the co-receptor that delivers growth factors to support tissue morphogenesis...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27699662/imaging-the-implant-soft-tissue-interactions-in-total-knee-arthroplasty
#11
Michel P Bonnin, Tom Van Hoof, Arnoud De Kok, Matthias Verstraete, Catherine Van der Straeten, Moreno Saffarini, Jan Victor
BACKGROUND: In Total Knee Arthroplasty (TKA), residual pain may be secondary to soft tissue impingements, which are difficult to visualize around chromium-cobalt implants using medical imaging, so their interactions remain poorly understood. The goal of this work was to establish a protocol for in-vitro imaging of the soft tissues around TKA, usable during throughout the range of motion (ROM). METHODS: The full size range of a commercially available TKA prosthesis was manufactured by 3D-printing in non-magnetic and non-radiopaque polymer and implanted in 12 cadaveric knees...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27624439/augmented-repair-of-radial-meniscus-tear-with-biomimetic-electrospun-scaffold-an-in-vitro-mechanical-analysis
#12
Benjamin B Rothrauff, Piya-On Numpaisal, Brian B Lauro, Peter G Alexander, Richard E Debski, Volker Musahl, Rocky S Tuan
BACKGROUND: Large radial tears that disrupt the circumferential fibers of the meniscus are associated with reduced meniscal function and increased risk of joint degeneration. Electrospun fibrous scaffolds can mimic the topography and mechanics of fibrocartilaginous tissues and simultaneously serve as carriers of cells and growth factors, yet their incorporation into clinically relevant suture repair techniques for radial meniscus tears is unexplored. The purposes of this study were to (1) evaluate the effect of fiber orientation on the tensile properties and suture-retention strength of multilayered electrospun scaffolds and (2) determine the mechanical effects of scaffold inclusion within a surgical repair of a simulated radial meniscal tear...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27624438/basic-science-of-osteoarthritis
#13
Magali Cucchiarini, Laura de Girolamo, Giuseppe Filardo, J Miguel Oliveira, Patrick Orth, Dietrich Pape, Pascal Reboul
Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic knowledge on OA that may lead to innovative end efficient new therapeutic regimens. While degradation of the articular cartilage is the hallmark of OA, with altered interactions between chondrocytes and compounds of the extracellular matrix, the subchondral bone has been also described as a key component of the disease, involving specific pathomechanisms controlling its initiation and progression...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27613708/five-year-publication-rate-of-clinical-presentations-at-the-open-and-closed-american-shoulder-and-elbow-surgeons-annual-meeting-from-2005-2010
#14
J Kay, M Memon, D de Sa, A Duong, N Simunovic, G S Athwal, O R Ayeni
BACKGROUND: The purpose of this study was to evaluate the five-year publication rate of papers presented at both the open and closed American Shoulder and Elbow Surgeons' (ASES) annual meetings from 2005 to 2010. METHODS: Online abstracts of the presentations at the open and closed ASES annual meetings were independently screened for clinical studies and graded for quality using level of evidence. The databases PubMed (MEDLINE), Ovid (MEDLINE), and EMBASE were comprehensively searched for full-text publications corresponding to these presentations and any paper published within five years of the presentation date was counted...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27600522/biomechanical-and-histological-comparison-between-the-cryopreserved-and-the-lyophilized-gracilis-tendon-allograft-for-mpfl-reconstruction-a-cadaveric-experimental-study
#15
Roberto Negrín, Jaime Duboy, Fernando Olavarría, Mauricio Wainer, Horacio Jimenez, Facundo Las Heras, Nicolas Reyes, Hugo Godoy
BACKGROUND: Medial patellofemoral ligament (MPFL) is the main restrictor of lateral shifting of the patella, contributing by 60 % in the first 20° flexion of the knee. MPFL reconstruction has been performed in order to restore the stability of the patella with good results.Lyophilized Gracilis tendon allograft (LGA) compared to Cryopreserved Gracilis tendon allograft (CGA) has a lower cost, does not require to maintain cooling chain or preparation. The purpose of this study is to compare the histological and biomechanical characteristics of an experimental model of reconstruction of the MPFL in porcine patellas with LGA versus CGA...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27578288/biomechanical-evaluation-of-shape-memory-alloy-staples-for-internal-fixation-an-in-vitro-study
#16
QiCai Jason Hoon, Matthew H Pelletier, Chris Christou, Kenneth A Johnson, William R Walsh
BACKGROUND: The field of orthopaedics is a constantly evolving discipline. Despite the historical success of plates, pins and screws in fracture reduction and stabilisation, there is a continuing search for more efficient and improved methods of fracture fixation. The aim of this study was to evaluate shape-memory staples and to compare them to a currently used implant for internal fracture fixation. Multi-plane bending stability and interfragmentary compression were assessed across a simulated osteotomy using single and double-staple fixation and compared to a bridging plate...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27539076/intra-articular-interleukin-1-receptor-antagonist-il1-ra-microspheres-for-posttraumatic-osteoarthritis-in-vitro-biological-activity-and-in-vivo-disease-modifying-effect
#17
Khaled A Elsaid, Anand Ubhe, Ziyad Shaman, Gerard D'Souza
BACKGROUND: Interleukin-1 receptor antagonist (IL-1 ra) can be disease-modifying in posttraumatic osteoarthritis (PTOA). One limitation is its short joint residence time. We hypothesized that IL-1 ra encapsulation in poly (lactide-co-glycolide) (PLGA) microspheres reduces IL-1 ra systemic absorption and provides an enhanced anti-PTOA effect. METHODS: IL-1 ra release kinetics and biological activity: IL-1 ra encapsulation into PLGA microsphere was performed using double emulsion solvent extraction...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27525982/functional-outcome-measures-in-a-surgical-model-of-hip-osteoarthritis-in-dogs
#18
Dianne Little, Stephen Johnson, Jonathan Hash, Steven A Olson, Bradley T Estes, Franklin T Moutos, B Duncan X Lascelles, Farshid Guilak
BACKGROUND: The hip is one of the most common sites of osteoarthritis in the body, second only to the knee in prevalence. However, current animal models of hip osteoarthritis have not been assessed using many of the functional outcome measures used in orthopaedics, a characteristic that could increase their utility in the evaluation of therapeutic interventions. The canine hip shares similarities with the human hip, and functional outcome measures are well documented in veterinary medicine, providing a baseline for pre-clinical evaluation of therapeutic strategies for the treatment of hip osteoarthritis...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27473203/effects-of-raav-mediated-fgf-2-gene-transfer-and-overexpression-upon-the-chondrogenic-differentiation-processes-in-human-bone-marrow-aspirates
#19
Janina Frisch, Jagadeesh K Venkatesan, Ana Rey-Rico, Adam M Zawada, Gertrud Schmitt, Henning Madry, Magali Cucchiarini
BACKGROUND: Application of genetically modified bone marrow concentrates in articular cartilage lesions is a promising approach to enhance cartilage repair by stimulating the chondrogenic differentiation processes in sites of injury. METHOD: In the present study, we examined the potential benefits of transferring the proliferative and pro-chondrogenic basic fibroblast growth factor (FGF-2) to human bone marrow aspirates in vitro using the clinically adapted recombinant adeno-associated virus (rAAV) vectors to monitor the biological and chondrogenic responses over time to the treatment compared with control (lacZ) gene application...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27447481/muscle-injuries-and-strategies-for-improving-their-repair
#20
REVIEW
Thomas Laumonier, Jacques Menetrey
Satellite cells are tissue resident muscle stem cells required for postnatal skeletal muscle growth and repair through replacement of damaged myofibers. Muscle regeneration is coordinated through different mechanisms, which imply cell-cell and cell-matrix interactions as well as extracellular secreted factors. Cellular dynamics during muscle regeneration are highly complex. Immune, fibrotic, vascular and myogenic cells appear with distinct temporal and spatial kinetics after muscle injury. Three main phases have been identified in the process of muscle regeneration; a destruction phase with the initial inflammatory response, a regeneration phase with activation and proliferation of satellite cells and a remodeling phase with maturation of the regenerated myofibers...
December 2016: Journal of Experimental Orthopaedics
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