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Journal of Experimental Orthopaedics

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https://www.readbyqxmd.com/read/29330713/low-field-magnetic-resonance-imaging-offers-potential-for-measuring-tibial-component-migration
#1
F F Schröder, N J J Verdonschot, B Ten Haken, A Peters, A J H Vochteloo, D F M Pakvis, R Huis In't Veld
BACKGROUND: Roentgen stereophotogrammetric analysis (RSA) is used to measure early prosthetic migration and to predict future implant failure. RSA has several disadvantages, such as the need for perioperatively inserted tantalum markers. Therefore, this study evaluates low-field MRI as an alternative to RSA. The use of traditional MRI with prostheses induces disturbing metal artifacts which are reduced by low-field MRI. The purpose of this study is to assess the feasibility to use low-field (0...
January 12, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29322270/recent-developments-in-evaluation-and-treatment-of-lateral-patellar-instability
#2
REVIEW
Alexander Zimmerer, Christian Sobau, Peter Balcarek
Recent years have been characterized by an ongoing increase in knowledge about the different conditions associated with lateral patellar instability. This increase in knowledge provides differentiated approaches to the various pathologies of the patellofemoral joint. Though current guidelines consider medial patellofemoral ligament (MPFL) reconstruction the basic treatment for the unstable patella, medial soft tissue-stabilizing procedures should not be interpreted as stand-alone procedures in every case. The influence of different anatomical factors leading to patellar instability, as well as their impact on clinical outcome measures, is becoming increasingly apparent and deserves further attention...
January 10, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29330730/scaffold-free-tissue-engineering-for-injured-joint-surface-restoration
#3
REVIEW
Kazunori Shimomura, Wataru Ando, Hiromichi Fujie, David A Hart, Hideki Yoshikawa, Norimasa Nakamura
Articular cartilage does not heal spontaneously due to its limited healing capacity, and thus effective treatments for cartilage injuries has remained challenging. Since the first report by Brittberg et al. in 1994, autologous chondrocyte implantation (ACI) has been introduced into the clinic. Recently, as an alternative for chondrocyte-based therapy, mesenchymal stem cell (MSC)-based therapy has received considerable research attention because of the relative ease in handling for tissue harvest, and subsequent cell expansion and differentiation...
January 5, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29330711/boosting-tendon-repair-interplay-of-cells-growth-factors-and-scaffold-free-and-gel-based-carriers
#4
REVIEW
Zexing Yan, Heyong Yin, Michael Nerlich, Christian G Pfeifer, Denitsa Docheva
BACKGROUND: Tendons are dense connective tissues and critical components for the integrity and function of the musculoskeletal system. Tendons connect bone to muscle and transmit forces on which locomotion entirely depends. Due to trauma, overuse and age-related degeneration, many people suffer from acute or chronic tendon injuries. Owing to their hypovascularity and hypocellularity, tendinopathies remain a substantial challenge for both clinicians and researchers. Surgical treatment includes suture or transplantation of autograft, allograft or xenograft, and these serve as the most common technique for rescuing tendon injuries...
January 5, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29260438/novel-flat-and-wide-meniscal-repair-material-improves-the-ultimate-load-of-knot-breakage-in-a-porcine-trans-capsular-meniscal-repair-model
#5
Hiroyuki Yokoi, Tatsuo Mae, Ryo Iuchi, Yasuhiro Take, Yuta Tachibana, Kazunori Shimomura, Tomoki Ohori, Konsei Shino, Hideki Yoshikawa, Ken Nakata
BACKGROUND: In the meniscal repair procedures, a high ultimate load capacity and low cyclic creep at the repair site are favorable and lead to good biological incorporation of the tear site after surgery. Previous biomechanical tensile tests of the meniscal sutures have identified the suture knot as the weakest point. We hypothesized that the strength of a suture knot depends on the suture shape, and therefore, we compared three differently shaped suture materials composed of the same material and quantity per length...
December 19, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29260429/intraarticular-arthrofibrosis-of-the-knee-alters-patellofemoral-contact-biomechanics
#6
Jacob D Mikula, Erik L Slette, Kimi D Dahl, Scott R Montgomery, Grant J Dornan, Luke O'Brien, Travis Lee Turnbull, Thomas R Hackett
BACKGROUND: Arthrofibrosis in the suprapatellar pouch and anterior interval can develop after knee injury or surgery, resulting in anterior knee pain. These adhesions have not been biomechanically characterized. METHODS: The biomechanical effects of adhesions in the suprapatellar pouch and anterior interval during simulated quadriceps muscle contraction from 0 to 90° of knee flexion were assessed. Adhesions of the suprapatellar pouch and anterior interval were hypothesized to alter the patellofemoral contact biomechanics and increase the patellofemoral contact force compared to no adhesions...
December 19, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29222607/static-and-fatigue-strength-of-a-novel-anatomically-contoured-implant-compared-to-five-current-open-wedge-high-tibial-osteotomy-plates
#7
Arnaud Diffo Kaze, Stefan Maas, James Belsey, Alexander Hoffmann, Dietrich Pape
BACKGROUND: The purpose of the present study was to compare the mechanical static and fatigue strength of the size 2 osteotomy plate "Activmotion" with the following five other common implants for the treatment of medial knee joint osteoarthritis: the TomoFix small stature, the TomoFix standard, the Contour Lock, the iBalance and the second generation PEEKPower. METHODS: Six fourth-generation tibial bone composites underwent a medial open-wedge high tibial osteotomy (HTO), according to standard techniques, using size 2 Activmotion osteotomy plates...
December 8, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28733950/tendon-end-separation-with-loading-in-an-achilles-tendon-repair-model-comparison-of-non-absorbable-vs-absorbable-sutures
#8
Michael R Carmont, Jan Herman Kuiper, Karin Grävare Silbernagel, Jón Karlsson, Katarina Nilsson-Helander
BACKGROUND: Rupture of the Achilles tendon often leads to long-term morbidity, particularly calf weakness associated with tendon elongation. Operative repair of Achilles tendon ruptures leads to reduced tendon elongation. Tendon lengthening is a key problem in the restoration of function following Achilles tendon rupture. A study was performed to determine differences in initial separation, strength and failure characteristics of differing sutures and numbers of core strands in a percutaneous Achilles tendon repair model in response to initial loading...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28730582/the-biochemical-and-histological-analysis-of-subcutaneous-calcitonin-and-intramedullary-methylprednisolone-on-bone-repair-after-bone-marrow-ablation-an-experimental-comparative-study-in-rats
#9
Salim Ersozlu, Bartu Sarisozen, Ozgur Ozer, Saduman Balaban Adim, Orcun Sahin
BACKGROUND: Although, glucocorticoid (GC) and calcitonin-induced changes in bone repair have been studied previously, the exact effects of these on fracture healing remain controversial. Hence, the purpose of this experimental study is to determine biochemical and histological effects of locally administrated GC and systemically administrated calcitonin on the kinetics of healing response after bone marrow ablation in rats. METHODS: After having undergone marrow ablation, a steroid-treated group of rats (n = 24) received a single dose of intramedullary methylprednisolone (2 mg/kg), a calcitonin-treated group (n = 24) received intermittently administrated subcutaneous salmon calcitonin (16 IU/kg), and a control group (n = 24) received intramedullary saline (25 μl)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28656567/varus-valgus-instability-in-the-anterior-cruciate-ligament-deficient-knee-effect-of-posterior-tibial-load
#10
Tomoki Ohori, Tatsuo Mae, Konsei Shino, Yuta Tachibana, Hiromichi Fujie, Hideki Yoshikawa, Ken Nakata
BACKGROUND: Anterior cruciate ligament (ACL) injury is often accompanied with medial collateral ligament (MCL) injury. Assessment of varus-valgus (V-V) instability in the ACL-deficient knee is crucial for the management of the concomitant ACL-collateral ligaments injury. We evaluated the V-V laxity and investigated the effect of additional posterior tibial load on the laxity in the ACL-deficient knee. Our hypothesis was that the V-V laxity in the ACL-deficient knee was greater than that in the intact knee and attenuated by additional posterior tibial load...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28646430/mechanical-strength-assessment-of-a-drilled-hole-in-the-contralateral-cortex-at-the-end-of-the-open-wedge-for-high-tibial-osteotomy
#11
Arnaud Diffo Kaze, Stefan Maas, Alexander Hoffmann, Dietrich Pape
BACKGROUND: This study aimed to investigate, by means of finite element analysis, the effect of a drill hole at the end of a horizontal osteotomy to reduce the risk of lateral cortex fracture while performing an opening wedge high tibial osteotomy (OWHTO). The question was whether drilling a hole relieves stress and increases the maximum correction angle without fracture of the lateral cortex depending on the ductility of the cortical bone. METHODS: Two different types of osteotomy cuts were considered; one with a drill hole (diameter 5 mm) and the other without the hole...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28634835/impact-of-mechanical-stimulation-on-the-chondrogenic-processes-in-human-bone-marrow-aspirates-modified-to-overexpress-sox9-via-raav-vectors
#12
Jagadeesh K Venkatesan, Janina Frisch, Ana Rey-Rico, Gertrud Schmitt, Henning Madry, Magali Cucchiarini
BACKGROUND: Evaluation of gene-based approaches to target human bone marrow aspirates in conditions of mechanical stimulation that aim at reproducing the natural joint environment may allow to develop improved treatments for articular cartilage injuries. In the present study, we investigated the potential of rAAV-mediated sox9 gene transfer to enhance the chondrogenic differentiation processes in human bone marrow aspirates under established hydrodynamic conditions compared with the more commonly employed static culture conditions...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28608283/geometric-morphometric-analysis-reveals-age-related-differences-in-the-distal-femur-of-europeans
#13
Etienne Cavaignac, Frederic Savall, Elodie Chantalat, Marie Faruch, Nicolas Reina, Philippe Chiron, Norbert Telmon
BACKGROUND: Few studies have looked into age-related variations in femur shape. We hypothesized that three-dimensional (3D) geometric morphometric analysis of the distal femur would reveal age-related differences. The purpose of this study was to show that differences in distal femur shape related to age could be identified, visualized, and quantified using three-dimensional (3D) geometric morphometric analysis. METHODS: Geometric morphometric analysis was carried out on CT scans of the distal femur of 256 subjects living in the south of France...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28585023/dynamic-radiostereometric-analysis-for-evaluation-of-hip-joint-pathomechanics
#14
Lars Hansen, Sepp de Raedt, Peter Bo Jørgensen, Bjarne Mygind-Klavsen, Bart Kaptein, Maiken Stilling
BACKGROUND: Dynamic RSA (dRSA) enables non-invasive 3D motion-tracking of bones and may be used to evaluate in-vivo hip joint kinematics including hip pathomechanics such as femoroacetabular impingement (FAI) and the biomechanical effects of arthroscopic cheilectomy and -rim trimming (ACH). The study aim was to evaluate the kinematic changes in the hip joint after ACH. METHODS: Seven non-FAI affected human cadaveric hips were CT-scanned and CT-bone models were created...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28577187/autofluorescence-imaging-for-improved-visualization-of-joint-structures-during-arthroscopic-surgery
#15
Duy Tan Nguyen, Pepijn van Horssen, Hans Derriks, Martijn van de Giessen, Ton van Leeuwen
BACKGROUND: The purpose of our study is to develop the arthroscopic autofluorescence imaging (AFI) system to improve the visualization during arthroscopic surgery by real-time enhancing the contrast between joint structures with autofluorescence imaging. Its validity was evaluated around the arthroscopic anterior cruciate ligament (ACL) reconstruction, specifically improving the contrast between the femoral insertion site and its background. The feasibility of the AFI system was validated with bovine and human knees...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28560707/current-trends-in-tendinopathy-consensus-of-the-esska-basic-science-committee-part-i-biology-biomechanics-anatomy-and-an-exercise-based-approach
#16
REVIEW
F Abat, H Alfredson, M Cucchiarini, H Madry, A Marmotti, C Mouton, J M Oliveira, H Pereira, G M Peretti, D Romero-Rodriguez, C Spang, J Stephen, C J A van Bergen, L de Girolamo
Chronic tendinopathies represent a major problem in the clinical practice of sports orthopaedic surgeons, sports doctors and other health professionals involved in the treatment of athletes and patients that perform repetitive actions. The lack of consensus relative to the diagnostic tools and treatment modalities represents a management dilemma for these professionals. With this review, the purpose of the ESSKA Basic Science Committee is to establish guidelines for understanding, diagnosing and treating this complex pathology...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28534321/does-anatomic-single-bundle-acl-reconstruction-using-hamstring-autograft-produce-anterolateral-meniscal-root-tearing
#17
Sebastián Irarrázaval, Angel Masferrer-Pino, Maximiliano Ibañez, Tamer M A Shehata, María Naharro, Joan C Monllau
BACKGROUND: To determine if tibial tunnel reaming during anatomic single-bundle anterior cruciate ligament (ACL) reconstruction using hamstring autograft can result in anterolateral meniscal root injury, as diagnosed by magnetic resonance imaging (MRI). METHODS: A case series of 104 primary anatomic single-bundle ACL reconstructions using hamstring autograft was retrospectively reviewed. Pre- and post-operative (>1 year) MRIs were radiologically evaluated for each patient, with a lateral meniscus extrusion > 3 mm at the level of the medial collateral ligament midportion on a coronal MRI, to establish anterolateral meniscal root injury...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28500483/the-effect-of-repetitive-flexion-and-extension-fatigue-loading-on-the-young-porcine-lumbar-spine-a-feasibility-study-of-mri-and-histological-analyses
#18
Olof Thoreson, Lars Ekström, Hans-Arne Hansson, Carl Todd, Wisam Witwit, Anna Swärd Aminoff, Pall Jonasson, Adad Baranto
BACKGROUND: The biomechanical mechanisms of failure of FSUs have been studied but the correlation of repetitive flexion and extension loadings to the initial phase of fatigue in young FSUs are still not known. The purpose of the study was to examine the fatigue results of low magnitude repetitive flexion and extension loading on porcine lumbar Functional Spinal Units (FSUs) with Magnetic Resonance Imaging (MRI) and histology. METHODS: Eight FSUs were subject to repetitive pivot flexion and eight to extension loading by a protocol of 20 000 cycles at 1 Hz with a load of 700 N...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28488256/the-rate-of-publication-of-free-papers-at-the-2008-and-2010-european-society-of-sports-traumatology-knee-surgery-and-arthroscopy-congresses
#19
Jeffrey Kay, Muzammil Memon, Joelle Rogozinsky, Darren de Sa, Nicole Simunovic, Romain Seil, Jon Karlsson, Olufemi Rolland Ayeni
BACKGROUND: The purpose of this study was to evaluate the frequency with which free papers presented at the 2008 and 2010 European Society of Sports Traumatology Knee Surgery and Arthroscopy (ESSKA) congress were ultimately published in peer-reviewed journals. Moreover, this study evaluated whether any correlations exist between the level of evidence of the free papers and their frequency of publication or the impact factor of the journals in which they are published. METHODS: Free papers presented at the 2008 and 2010 ESSKA congresses were included for assessment...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28470629/hyaluronan-thiomer-gel-matrix-mediated-healing-of-articular-cartilage-defects-in-new-zealand-white-rabbits-a-pilot-study
#20
Christoph Bauer, Vivek Jeyakumar, Eugenia Niculescu-Morzsa, Daniela Kern, Stefan Nehrer
BACKGROUND: Articular cartilage defects are limited to their regenerative potential in human adults. Our current study evaluates tissue regeneration in a surgically induced empty defect site with hyaluronan thiomer as a provisional scaffold in a gel/matrix combination without cells on rabbit models to restore tissue formation. METHODS: An osteochondral defect of 4 mm in diameter and 5 mm in depth was induced by mechanical drilling in the femoral center of the trochlea in 18 New Zealand White rabbits...
December 2017: Journal of Experimental Orthopaedics
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