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Journal of Experimental Orthopaedics

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https://www.readbyqxmd.com/read/28425031/the-cytokine-expression-in-synovial-membrane-and-the-relationship-with-pain-and-pathological-findings-at-hip-arthroscopy
#1
Kensuke Fukushima, Gen Inoue, Hisako Fujimaki, Kentaro Uchida, Masayuki Miyagi, Naoshige Nagura, Katsufumi Uchiyama, Naonobu Takahira, Masashi Takaso
BACKGROUND: Synovial membrane inflammation is the most common finding presenting during hip arthroscopy, and may play a role in hip pain. We sought to determine the relationships between synovial cytokine levels, hip pain, and arthroscopic findings of the hip joint. METHODS: We prospectively included 33 patients who underwent arthroscopic hip surgery (34 hips). For all patients, radiographs and severity of pain were evaluated preoperatively. During arthroscopy, we classified the chondral injury and synovitis, noted the incidence of labral tear and its instability, and a sample of the synovial membrane was harvested for quantitative PCR to determine levels of TNFα, IL1β, IL6, ADAMTS4, MMP1, and MMP3...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28417444/a-retinaculum-sparing-surgical-approach-preserves-porcine-stifle-joint-cartilage-in-an-experimental-animal-model-of-cartilage-repair
#2
Marcelo B Bonadio, James M Friedman, Mackenzie L Sennett, Robert L Mauck, George R Dodge, Henning Madry
BACKGROUND: This study compares a traditional parapatellar retinaculum-sacrificing arthrotomy to a retinaculum-sparing arthrotomy in a porcine stifle joint as a cartilage repair model. FINDINGS: Surgical exposure of the femoral trochlea of ten Yucatan pigs stifle joint was performed using either a traditional medial parapatellar approach with retinaculum incision and luxation of the patella (n = 5) or a minimally invasive (MIS) approach which spared the patellar retinaculum (n = 5)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28361277/the-effect-of-a-dynamic-pcl-brace-on-patellofemoral-compartment-pressures-in-pcl-and-pcl-plc-deficient-knees
#3
Tyler Welch, Thomas Keller, Ruben Maldonado, Melodie Metzger, Karen Mohr, Ronald Kvitne
BACKGROUND: The natural history of posterior cruciate ligament (PCL) deficiency includes the development of arthrosis in the patellofemoral joint (PFJ). The purpose of this biomechanical study was to evaluate the hypothesis that dynamic bracing reduces PFJ pressures in PCL- and combined PCL/posterolateral corner (PLC)-deficient knees. STUDY DESIGN: Controlled Laboratory Study. METHODS: Eight fresh frozen cadaveric knees with intact cruciate and collateral ligaments were included...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28332149/biomechanical-cadaveric-comparison-of-patellar-ligament-suture-protected-by-a-steel-cable-versus-a-synthetic-cable
#4
P Bouget, C Breque, J S Beranger, J P Faure, F Khiami, T Vendeuvre
BACKGROUND: Purpose and hypothesis: Patellar ligament rupture is a rare disabling pathology requiring a surgical ligament suture protected by a frame. The gold standard is the steel cable, but its rigidity and the necessity of a surgical re-intervention for its removal render it unsatisfactory. The objective of this paper is to quantify the mechanical protection provided by the terylene® in comparison with steel. METHODS: Twenty-four knees of 12 fresh frozen cadaveric subjects were divided into 2 homogeneous groups (terylene and steel) of 12 knees (mean age = 69...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28244027/different-culture-conditions-affect-the-growth-of-human-tendon-stem-progenitor-cells-tspcs-within-a-mixed-tendon-cells-tcs-population
#5
M Viganò, C Perucca Orfei, A Colombini, D Stanco, P Randelli, V Sansone, L de Girolamo
BACKGROUND: Tendon resident cells (TCs) are a mixed population made of terminally differentiated tenocytes and tendon stem/progenitor cells (TSPCs). Since the enrichment of progenitors proportion could enhance the effectiveness of treatments based on these cell populations, the interest on the effect of culture conditions on the TSPCs is growing. In this study the clonal selection and the culture in presence or absence of basic fibroblast growth factor (bFGF) were used to assess their influences on the stemness properties and phenotype specific features of tendon cells...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28229430/differences-in-biomarkers-of-cartilage-matrix-turnover-and-their-changes-over-2%C3%A2-years-in-adolescent-and-adult-volleyball-athletes
#6
Heide Boeth, Aoife MacMahon, A Robin Poole, Frank Buttgereit, Patrik Önnerfjord, Pilar Lorenzo, Cecilia Klint, Anna Pramhed, Georg N Duda
BACKGROUND: This study aimed the feasibility to assess longitudinal changes in biomarkers of cartilage turnover and to determine their relationship with patient-rated outcomes over 2 years in volleyball athletes. METHODS: Thirty-seven athletes were studied: 18 adolescents (age 15.9 ± 0.64 years) in a 2-year intensive volleyball training program and 19 adult recreational volleyball players (age 46.5 ± 4.9 years). Blood and serum samples were taken at baseline (BL) and 2-year follow-up (FU)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28224374/mri-findings-of-knee-abnormalities-in-adolescent-and-adult-volleyball-players
#7
Heide Boeth, Aoife MacMahon, Felix Eckstein, Gerd Diederichs, Arne Schlausch, Wolfgang Wirth, Georg N Duda
BACKGROUND: To longitudinally and cross-sectionally evaluate knee abnormalities by sex and age in adolescent and adult volleyball athletes over 2 years using magnetic resonance imaging (MRI). METHODS: Thirty-six high-level volleyball athletes (18 adolescents: 56% female, mean age 16.0 ± 0.8 years; and 18 adults: 50% female, mean age 46.8 ± 5.1 years) were imaged by MRI at BL and at 2-year follow-up (FU). Prevalence and severity of cartilage lesions, subarticular bone marrow lesions (BMLs), subarticular cysts, osteophytes, and ligament and meniscus integrity were evaluated by sex and by age cohort (adolescents and adults) using the whole-organ MRI score (WORMS)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28176273/the-haematoma-and-its-role-in-bone-healing
#8
REVIEW
H Schell, G N Duda, A Peters, S Tsitsilonis, K A Johnson, K Schmidt-Bleek
Fracture treatment is an old endeavour intended to promote bone healing and to also enable early loading and regain of function in the injured limb. However, in today's clinical routine the healing potential of the initial fracture haematoma is still not fully recognized. The Arbeitsgemeinschaft für Osteosynthesefragen (AO) formed in Switzerland in 1956 formulated four AO principles of fracture treatment which are still valid today. Fracture treatment strategies have continued to evolve further, as for example the relatively new concept of minimally invasive plate osteosynthesis (MIPO)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28176272/effects-of-combined-raav-mediated-tgf-%C3%AE-and-sox9-gene-transfer-and-overexpression-on-the-metabolic-and-chondrogenic-activities-in-human-bone-marrow-aspirates
#9
Ke Tao, Ana Rey-Rico, Janina Frisch, Jagadeesh Kumar Venkatesan, Gertrud Schmitt, Henning Madry, Jianhao Lin, Magali Cucchiarini
BACKGROUND: Transplantation of genetically modified bone marrow concentrates is an attractive approach to conveniently activate the chondrogenic differentiation processes as a means to improve the intrinsic repair capacities of damaged articular cartilage. METHODS: Human bone marrow aspirates were co-transduced with recombinant adeno-associated virus (rAAV) vectors to overexpress the pleiotropic transformation growth factor beta (TGF-β) and the cartilage-specific transcription factor sox9 as a means to enhance the chondroreparative processes in conditions of specific lineage differentiation...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28144820/a-preclinical-numerical-assessment-of-a-polyetheretherketone-femoral-component-in-total-knee-arthroplasty-during-gait
#10
Lennert de Ruiter, Dennis Janssen, Adam Briscoe, Nico Verdonschot
BACKGROUND: Conventional total knee replacement designs show high success rates but in the long term, the stiff metal components may affect bone quality of the distal femur. In this study we introduce an all-polymer total knee replacement device containing a PEEK femoral component on an UHMWPE tibial implant and study its mechanical integrity, fixation, and stress shielding of the periprosthetic femur. METHODS: The implant was analysed in finite element simulations of level gait, adopted from the ISO 14243-1 standard...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28124287/biomechanical-testing-of-transcapsular-meniscal-repair
#11
Ryo Iuchi, Tatsuo Mae, Konsei Shino, Tomohiko Matsuo, Hideki Yoshikawa, Ken Nakata
BACKGROUND: All of previous biomechanical studies on meniscal repair have examined the meniscus itself without synovial membrane and capsule, although in the clinical setting, the meniscal repair is generally performed including capsule. Therefore, biomechanical properties of transcapsular meniscal repair are unclear. Thus, this study aimed to clarify the biomechanical properties of transcapsular meniscal repair. METHODS: In 70 porcine femur-medial meniscus-tibia complexes with capsules, longitudinal meniscal tears were repaired using different suture techniques (inside-out or all-inside technique), suture methods (vertical or horizontal methods), and numbers of sutures (single or double)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28116554/patient-perceptions-regarding-physician-reimbursements-wait-times-and-out-of-pocket-payments-for-anterior-cruciate-ligament-reconstruction-in-ontario
#12
Muzammil Memon, Lydia Ginsberg, Darren de Sa, Andrew Nashed, Nicole Simunovic, Mark Phillips, Matthew Denkers, Rick Ogilvie, Devin Peterson, Olufemi R Ayeni
BACKGROUND: Currently, there is a lack of knowledge regarding patient perceptions surrounding physician reimbursements, appropriate wait times, and out-of-pocket payment options for anterior cruciate ligament reconstruction (ACLR). Our objective was to determine the current state of these perceptions in an Ontario setting. METHODS: A survey was developed and pretested to address patient perceptions about physician reimbursements, appropriate wait times, and out-of-pocket payment options for ACLR using a focus group of experts and by reviewing prior surveys...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28012152/erratum-to-bone-marrow-aspirate-concentrate-for-the-treatment-of-osteochondral-lesions-of-the-talus-a-systematic-review-of-outcomes
#13
Jorge Chahla, Mark E Cinque, Jason M Schon, Daniel J Liechti, Lauren M Matheny, Robert F LaPrade, Thomas O Clanton
No abstract text is available yet for this article.
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27957713/drill-wobble-effect-on-femoral-tunnel-aperture-during-anterior-cruciate-ligament-reconstruction
#14
Naser Alnusif, Adam Hart, Maher Baroudi, Robert Marien, Mark Burman, Paul A Martineau
BACKGROUND: In anterior cruciate ligament reconstruction performed using cortical button fixation on the femur, we have observed a "wobble" effect that can occur when a cannulated femoral drill is used over a guide pin that is not securely fixed in bone. Our study assessed the effect of drill "wobble" on femoral tunnel aperture in sawbones. METHODS: Femoral tunnels were drilled in sawbones, which had been divided in two groups of 10 each, per drilling technique...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27943224/quantitative-computed-tomography-qct-derived-bone-mineral-density-bmd-in-finite-element-studies-a-review-of-the-literature
#15
REVIEW
Nikolas K Knowles, Jacob M Reeves, Louis M Ferreira
BACKGROUND: Finite element modeling of human bone provides a powerful tool to evaluate a wide variety of outcomes in a highly repeatable and parametric manner. These models are most often derived from computed tomography data, with mechanical properties related to bone mineral density (BMD) from the x-ray energy attenuation provided from this data. To increase accuracy, many researchers report the use of quantitative computed tomography (QCT), in which a calibration phantom is used during image acquisition to improve the estimation of BMD...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27928740/anatomical-study-comparing-the-human-sheep-and-pig-knee-meniscus
#16
Talal Takroni, Leila Laouar, Adetola Adesida, Janet A W Elliott, Nadr M Jomha
BACKGROUND: Animal models are commonly used in investigating new treatment options for knee joint injuries including injuries to the meniscus. The reliability and applicability of these models to replicate findings in humans depends on determining the most suitable animal proxy. Therefore, this study was designed to compare the wet weight, volume and dimensions of the human meniscus with two commonly used animal models: sheep and pig. METHODS: Human menisci (n = 6 pairs) were obtained from the knee joints of cadaveric male donors...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27854082/randomized-controlled-trial-comparing-the-effectiveness-of-the-ultrasound-guided-galvanic-electrolysis-technique-usget-versus-conventional-electro-physiotherapeutic-treatment-on-patellar-tendinopathy
#17
F Abat, J L Sánchez-Sánchez, A M Martín-Nogueras, J I Calvo-Arenillas, J Yajeya, R Méndez-Sánchez, J C Monllau, P E Gelber
BACKGROUND: Patellar tendinopathy has a high prevalence rate among athletes. Different therapeutic options can be found in the current literature, but none of them has been clearly established as the gold standard. The purpose of this study is to compare, in a randomized controlled trial, the clinical efficacy of eccentric exercise combined with either an ultrasound-guided galvanic electrolysis technique (USGET) or conventional electrophysiotherapy to treat patellar tendinopathy. METHODS: Sixty patients diagnosed with patellar tendinopathy were randomized into two groups...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27813021/bone-marrow-aspirate-concentrate-for-the-treatment-of-osteochondral-lesions-of-the-talus-a-systematic-review-of-outcomes
#18
REVIEW
Jorge Chahla, Mark E Cinque, Jason M Shon, Daniel J Liechti, Lauren M Matheny, Robert F LaPrade, Thomas O Clanton
BACKGROUND: The goal of this perform a systematic review on the outcomes of bone marrow aspirate concentrate (BMAC) for the treatment of chondral defects and osteoarthritis (OA) of the talus. RESULTS: The systematic search performed identified 47 studies after duplicates were removed. After inclusion criteria were applied four studies were considered for insightful analysis for the treatment of focal chondral defects in the foot and ankle with the use of BMAC. Three studies were retrospective and one study was prospective in nature...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27813020/new-insight-in-the-architecture-of-the-quadriceps-tendon
#19
Karl Grob, Mirjana Manestar, Luis Filgueira, Timothy Ackland, Helen Gilbey, Markus S Kuster
BACKGROUND: Published data regarding the structure of the quadriceps tendon are diverse. Dissection of the quadriceps muscle group revealed that beside the rectus femoris, vastus lateralis, vastus intermedius and vastus medialis a fifth muscle component- named the tensor vastus intermedius consistently fused into quadriceps tendon. It can be hypothesized that all these elements of the extensor apparatus of the knee joint must also be represented in the quadriceps tendon. This study investigated the multi-layered quadriceps tendon with special emphasis on all components of the quadriceps muscle group including the newly discovered tensor vastus intermedius...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27813019/knee-donor-site-morbidity-after-mosaicplasty-a-systematic-review
#20
REVIEW
Renato Andrade, Sebastiano Vasta, Rogério Pereira, Hélder Pereira, Rocco Papalia, Mustafa Karahan, J Miguel Oliveira, Rui L Reis, João Espregueira-Mendes
BACKGROUND: Mosaicplasty has been associated with good short- to long-term results. Nevertheless, the osteochondral harvesting is restricted to the donor-site area available and it may lead to significant donor-site morbidity. PURPOSE: Provide an overview of donor-site morbidity associated with harvesting of osteochondral plugs from the knee joint in mosaicplasty procedure. METHODS: Comprehensive search using Pubmed, Cochrane Library, SPORTDiscus and CINAHL databases was carried out through 10(th) October of 2016...
December 2016: Journal of Experimental Orthopaedics
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