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Journal of Experimental Orthopaedics

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https://www.readbyqxmd.com/read/29675769/cellular-and-molecular-meniscal-changes-in-the-degenerative-knee-a-review
#1
REVIEW
Mariano López-Franco, Enrique Gómez-Barrena
BACKGROUND: The important role of knee menisci to maintain adequate knee function is frequently impaired since early stages of knee joint degeneration. A better understanding of meniscal impairment may help the orthopaedic surgeon to orient the treatment of the degenerative knee. This review focuses on changes in meniscal cells and matrix when degeneration is in progress. MAIN BODY: Differences in the meniscal structure and metabolism have been investigated in the degenerative knee, both in experimental animal models and in surgical specimens...
April 19, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29607459/the-role-of-meniscal-repair-for-prevention-of-early-onset-of-osteoarthritis
#2
REVIEW
Johannes Weber, Matthias Koch, Peter Angele, Johannes Zellner
BACKGROUND: The meniscus plays an important role in the integrity of the knee joint. Therefore, meniscus tissue preserving techniques for the therapy of meniscus injuries seem to be reasonable. One of the important questions is whether meniscal repair can prevent the knee joint from early onset of osteoarthritis. METHODS: According to the review of the current literature, the principles of a successful meniscal repair are explained and the functional outcome and its impact on the prevention of osteoarthritis are analyzed in this article...
April 2, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29589162/the-capsular-line-reference-a-new-arthroscopic-reference-for-posterior-anterior-femoral-tunnel-positioning-in-anterior-cruciate-ligament-reconstruction
#3
Philippe Colombet, Alain Silvestre, Nicolas Bouguennec
BACKGROUND: Femoral malposition is the first cause for graft rupture during ACL reconstruction. Arthroscopic landmarks can be difficult to identify. So, landmark has to be found for reliable tunnel placement. A proximal-distal reference was described as "Apex reference" reported by Hart et al. but no posterior/anterior reference exists in the literature. The purpose of this study was to do a 3D CT-scan assessment of the femoral tunnel positioning using the Capsular Line Reference (CLR) as a landmark for posterior/anterior placement in ACL reconstruction...
March 27, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29557999/sublingual-sufentanil-tablet-system-zalviso%C3%A2-for-postoperative-analgesia-after-knee-replacement-in-fast-track-surgery-a-pilot-observational-study
#4
Marco Scardino, Tiziana D'Amato, Federica Martorelli, Giorgia Fenocchio, Vincenzo Simili, Berardo Di Matteo, Dario Bugada, Elizaveta Kon
BACKGROUND: Currently many TKA protocols rely on multimodal analgesic protocols with patient-controlled analgesia systems that administer opioids through a patient controlled IV infusion pump, in addition to concomitant peripheral nerve blocks and local anesthetics. Although effective, PCA IV opioids do not provide optimal results with fast track rehabilitation protocols. METHODS: The present is a retrospective study comparing the novel sublingual sufentanil PCA system (SSTS) to our standard of care foreseeing continuous femoral nerve block (cFNB) within a multimodal analgesic in a TKA fast-track protocol...
March 20, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29546506/translational-movement-within-the-glenohumeral-joint-at-different-rotation-velocities-as-seen-by-cine-mri
#5
Kazuhisa Matsui, Takashi Tachibana, Katsuya Nobuhara, Yasushi Uchiyama
BACKGROUND: The glenohumeral joint is subjected to opposing forces when the direction of shoulder motion is changed, accelerating and decelerating to make the movements. The influence of motion velocity or acceleration on translation of the humeral head has not been evaluated although direction and distance of humeral head translation has been analyzed in real time in normal shoulders. We hypothesized that, in a normal shoulder, the humeral head does not deviate significantly or suddenly during active shoulder rotation regardless of motion velocity...
March 15, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29536282/open-versus-arthroscopic-repair-of-the-triangular-fibrocartilage-complex-a-systematic-review
#6
REVIEW
Jonny K Andersson, Martina Åhlén, Daniel Andernord
BACKGROUND AND PURPOSE: To investigate the outcome of open versus arthroscopic repair of injuries of the triangular fibrocartilage complex (TFCC). METHODS: An electronic literature search of articles published between January 1, 1985, and May 26, 2016, in PubMed, Embase, and the Cochrane Library was carried out in May 2016 and updated in March and December 2017. Studies comparing open and arthroscopic repair of TFCC injury with a mean follow up of more than 1 year were eligible for inclusion...
March 13, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29484517/arthroscopic-bone-graft-procedure-combined-with-arthroscopic-subscapularis-augmentation-asa-for-recurrent-anterior-instability-with-glenoid-bone-defect-a-cadaver-study
#7
Raffaele Russo, Marco Maiotti, Ettore Taverna
BACKGROUND: Glenoid bone loss and capsular deficiency represent critical points of arthroscopic Bankart repair failures. The purpose of this study was to evaluate an all-arthroscopic bone block procedure associated with arthroscopic subscapularis augmentation (ASA) for treating gleno-humeral instability with glenoid bone loss (GBL) and anterior capsulo-labral deficiency. Our hypothesis was that these two procedures could be combined arthroscopically. The feasibility of this technique and its reproducibility, and potential neurovascular complications were evaluated...
February 27, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29330713/low-field-magnetic-resonance-imaging-offers-potential-for-measuring-tibial-component-migration
#8
F F Schröder, N J J Verdonschot, B Ten Haken, A Peters, A J H Vochteloo, D F M Pakvis, R Huis In't Veld
BACKGROUND: Roentgen stereophotogrammetric analysis (RSA) is used to measure early prosthetic migration and to predict future implant failure. RSA has several disadvantages, such as the need for perioperatively inserted tantalum markers. Therefore, this study evaluates low-field MRI as an alternative to RSA. The use of traditional MRI with prostheses induces disturbing metal artifacts which are reduced by low-field MRI. The purpose of this study is to assess the feasibility to use low-field (0...
January 12, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29322270/recent-developments-in-evaluation-and-treatment-of-lateral-patellar-instability
#9
REVIEW
Alexander Zimmerer, Christian Sobau, Peter Balcarek
Recent years have been characterized by an ongoing increase in knowledge about the different conditions associated with lateral patellar instability. This increase in knowledge provides differentiated approaches to the various pathologies of the patellofemoral joint. Though current guidelines consider medial patellofemoral ligament (MPFL) reconstruction the basic treatment for the unstable patella, medial soft tissue-stabilizing procedures should not be interpreted as stand-alone procedures in every case. The influence of different anatomical factors leading to patellar instability, as well as their impact on clinical outcome measures, is becoming increasingly apparent and deserves further attention...
January 10, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29330730/scaffold-free-tissue-engineering-for-injured-joint-surface-restoration
#10
REVIEW
Kazunori Shimomura, Wataru Ando, Hiromichi Fujie, David A Hart, Hideki Yoshikawa, Norimasa Nakamura
Articular cartilage does not heal spontaneously due to its limited healing capacity, and thus effective treatments for cartilage injuries has remained challenging. Since the first report by Brittberg et al. in 1994, autologous chondrocyte implantation (ACI) has been introduced into the clinic. Recently, as an alternative for chondrocyte-based therapy, mesenchymal stem cell (MSC)-based therapy has received considerable research attention because of the relative ease in handling for tissue harvest, and subsequent cell expansion and differentiation...
January 5, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29330711/boosting-tendon-repair-interplay-of-cells-growth-factors-and-scaffold-free-and-gel-based-carriers
#11
REVIEW
Zexing Yan, Heyong Yin, Michael Nerlich, Christian G Pfeifer, Denitsa Docheva
BACKGROUND: Tendons are dense connective tissues and critical components for the integrity and function of the musculoskeletal system. Tendons connect bone to muscle and transmit forces on which locomotion entirely depends. Due to trauma, overuse and age-related degeneration, many people suffer from acute or chronic tendon injuries. Owing to their hypovascularity and hypocellularity, tendinopathies remain a substantial challenge for both clinicians and researchers. Surgical treatment includes suture or transplantation of autograft, allograft or xenograft, and these serve as the most common technique for rescuing tendon injuries...
January 5, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29260438/novel-flat-and-wide-meniscal-repair-material-improves-the-ultimate-load-of-knot-breakage-in-a-porcine-trans-capsular-meniscal-repair-model
#12
Hiroyuki Yokoi, Tatsuo Mae, Ryo Iuchi, Yasuhiro Take, Yuta Tachibana, Kazunori Shimomura, Tomoki Ohori, Konsei Shino, Hideki Yoshikawa, Ken Nakata
BACKGROUND: In the meniscal repair procedures, a high ultimate load capacity and low cyclic creep at the repair site are favorable and lead to good biological incorporation of the tear site after surgery. Previous biomechanical tensile tests of the meniscal sutures have identified the suture knot as the weakest point. We hypothesized that the strength of a suture knot depends on the suture shape, and therefore, we compared three differently shaped suture materials composed of the same material and quantity per length...
December 19, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29260429/intraarticular-arthrofibrosis-of-the-knee-alters-patellofemoral-contact-biomechanics
#13
Jacob D Mikula, Erik L Slette, Kimi D Dahl, Scott R Montgomery, Grant J Dornan, Luke O'Brien, Travis Lee Turnbull, Thomas R Hackett
BACKGROUND: Arthrofibrosis in the suprapatellar pouch and anterior interval can develop after knee injury or surgery, resulting in anterior knee pain. These adhesions have not been biomechanically characterized. METHODS: The biomechanical effects of adhesions in the suprapatellar pouch and anterior interval during simulated quadriceps muscle contraction from 0 to 90° of knee flexion were assessed. Adhesions of the suprapatellar pouch and anterior interval were hypothesized to alter the patellofemoral contact biomechanics and increase the patellofemoral contact force compared to no adhesions...
December 19, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29222607/static-and-fatigue-strength-of-a-novel-anatomically-contoured-implant-compared-to-five-current-open-wedge-high-tibial-osteotomy-plates
#14
Arnaud Diffo Kaze, Stefan Maas, James Belsey, Alexander Hoffmann, Dietrich Pape
BACKGROUND: The purpose of the present study was to compare the mechanical static and fatigue strength of the size 2 osteotomy plate "Activmotion" with the following five other common implants for the treatment of medial knee joint osteoarthritis: the TomoFix small stature, the TomoFix standard, the Contour Lock, the iBalance and the second generation PEEKPower. METHODS: Six fourth-generation tibial bone composites underwent a medial open-wedge high tibial osteotomy (HTO), according to standard techniques, using size 2 Activmotion osteotomy plates...
December 8, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28733950/tendon-end-separation-with-loading-in-an-achilles-tendon-repair-model-comparison-of-non-absorbable-vs-absorbable-sutures
#15
Michael R Carmont, Jan Herman Kuiper, Karin Grävare Silbernagel, Jón Karlsson, Katarina Nilsson-Helander
BACKGROUND: Rupture of the Achilles tendon often leads to long-term morbidity, particularly calf weakness associated with tendon elongation. Operative repair of Achilles tendon ruptures leads to reduced tendon elongation. Tendon lengthening is a key problem in the restoration of function following Achilles tendon rupture. A study was performed to determine differences in initial separation, strength and failure characteristics of differing sutures and numbers of core strands in a percutaneous Achilles tendon repair model in response to initial loading...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28730582/the-biochemical-and-histological-analysis-of-subcutaneous-calcitonin-and-intramedullary-methylprednisolone-on-bone-repair-after-bone-marrow-ablation-an-experimental-comparative-study-in-rats
#16
Salim Ersozlu, Bartu Sarisozen, Ozgur Ozer, Saduman Balaban Adim, Orcun Sahin
BACKGROUND: Although, glucocorticoid (GC) and calcitonin-induced changes in bone repair have been studied previously, the exact effects of these on fracture healing remain controversial. Hence, the purpose of this experimental study is to determine biochemical and histological effects of locally administrated GC and systemically administrated calcitonin on the kinetics of healing response after bone marrow ablation in rats. METHODS: After having undergone marrow ablation, a steroid-treated group of rats (n = 24) received a single dose of intramedullary methylprednisolone (2 mg/kg), a calcitonin-treated group (n = 24) received intermittently administrated subcutaneous salmon calcitonin (16 IU/kg), and a control group (n = 24) received intramedullary saline (25 μl)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28656567/varus-valgus-instability-in-the-anterior-cruciate-ligament-deficient-knee-effect-of-posterior-tibial-load
#17
Tomoki Ohori, Tatsuo Mae, Konsei Shino, Yuta Tachibana, Hiromichi Fujie, Hideki Yoshikawa, Ken Nakata
BACKGROUND: Anterior cruciate ligament (ACL) injury is often accompanied with medial collateral ligament (MCL) injury. Assessment of varus-valgus (V-V) instability in the ACL-deficient knee is crucial for the management of the concomitant ACL-collateral ligaments injury. We evaluated the V-V laxity and investigated the effect of additional posterior tibial load on the laxity in the ACL-deficient knee. Our hypothesis was that the V-V laxity in the ACL-deficient knee was greater than that in the intact knee and attenuated by additional posterior tibial load...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28646430/mechanical-strength-assessment-of-a-drilled-hole-in-the-contralateral-cortex-at-the-end-of-the-open-wedge-for-high-tibial-osteotomy
#18
Arnaud Diffo Kaze, Stefan Maas, Alexander Hoffmann, Dietrich Pape
BACKGROUND: This study aimed to investigate, by means of finite element analysis, the effect of a drill hole at the end of a horizontal osteotomy to reduce the risk of lateral cortex fracture while performing an opening wedge high tibial osteotomy (OWHTO). The question was whether drilling a hole relieves stress and increases the maximum correction angle without fracture of the lateral cortex depending on the ductility of the cortical bone. METHODS: Two different types of osteotomy cuts were considered; one with a drill hole (diameter 5 mm) and the other without the hole...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28634835/impact-of-mechanical-stimulation-on-the-chondrogenic-processes-in-human-bone-marrow-aspirates-modified-to-overexpress-sox9-via-raav-vectors
#19
Jagadeesh K Venkatesan, Janina Frisch, Ana Rey-Rico, Gertrud Schmitt, Henning Madry, Magali Cucchiarini
BACKGROUND: Evaluation of gene-based approaches to target human bone marrow aspirates in conditions of mechanical stimulation that aim at reproducing the natural joint environment may allow to develop improved treatments for articular cartilage injuries. In the present study, we investigated the potential of rAAV-mediated sox9 gene transfer to enhance the chondrogenic differentiation processes in human bone marrow aspirates under established hydrodynamic conditions compared with the more commonly employed static culture conditions...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28608283/geometric-morphometric-analysis-reveals-age-related-differences-in-the-distal-femur-of-europeans
#20
Etienne Cavaignac, Frederic Savall, Elodie Chantalat, Marie Faruch, Nicolas Reina, Philippe Chiron, Norbert Telmon
BACKGROUND: Few studies have looked into age-related variations in femur shape. We hypothesized that three-dimensional (3D) geometric morphometric analysis of the distal femur would reveal age-related differences. The purpose of this study was to show that differences in distal femur shape related to age could be identified, visualized, and quantified using three-dimensional (3D) geometric morphometric analysis. METHODS: Geometric morphometric analysis was carried out on CT scans of the distal femur of 256 subjects living in the south of France...
December 2017: Journal of Experimental Orthopaedics
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