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Environmental Epigenetics

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https://www.readbyqxmd.com/read/29992049/diet-changes-alter-paternally-inherited-epigenetic-pattern-in-male-wild-guinea-pigs
#1
A Weyrich, M Jeschek, K T Schrapers, D Lenz, T H Chung, K Rübensam, S Yasar, M Schneemann, S Ortmann, K Jewgenow, J Fickel
Epigenetic modifications, of which DNA methylation is the most stable, are a mechanism conveying environmental information to subsequent generations via parental germ lines. The paternal contribution to adaptive processes in the offspring might be crucial, but has been widely neglected in comparison to the maternal one. To address the paternal impact on the offspring's adaptability to changes in diet composition, we investigated if low protein diet (LPD) in F0 males caused epigenetic alterations in their subsequently sired sons...
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29732173/alterations-in-sperm-dna-methylation-non-coding-rna-expression-and-histone-retention-mediate-vinclozolin-induced-epigenetic-transgenerational-inheritance-of-disease
#2
Millissia Ben Maamar, Ingrid Sadler-Riggleman, Daniel Beck, Margaux McBirney, Eric Nilsson, Rachel Klukovich, Yeming Xie, Chong Tang, Wei Yan, Michael K Skinner
Epigenetic transgenerational inheritance of disease and phenotypic variation can be induced by several toxicants, such as vinclozolin. This phenomenon can involve DNA methylation, non-coding RNA (ncRNA) and histone retention, and/or modification in the germline (e.g. sperm). These different epigenetic marks are called epimutations and can transmit in part the transgenerational phenotypes. This study was designed to investigate the vinclozolin-induced concurrent alterations of a number of different epigenetic factors, including DNA methylation, ncRNA, and histone retention in rat sperm...
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29732172/transgenerational-epigenetic-inheritance-in-birds
#3
REVIEW
Carlos Guerrero-Bosagna, Mireille Morisson, Laurence Liaubet, T Bas Rodenburg, Elske N de Haas, Ľubor Košťál, Frédérique Pitel
While it has been shown that epigenetics accounts for a portion of the variability of complex traits linked to interactions with the environment, the real contribution of epigenetics to phenotypic variation remains to be assessed. In recent years, a growing number of studies have revealed that epigenetic modifications can be transmitted across generations in several animal species. Numerous studies have demonstrated inter- or multi-generational effects of changing environment in birds, but very few studies have been published showing epigenetic transgenerational inheritance in these species...
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29732171/pohad-why-we-should-study-future-fathers
#4
Adelheid Soubry
The growing field of 'Developmental Origin of Health and Disease' (DOHaD) generally reflects environmental influences from mother to child. The importance of maternal lifestyle, diet and other environmental exposures before and during gestation period is well recognized. However, few epidemiological designs explore potential influences from the paternal environment on offspring health. This is surprising given that numerous animal models have provided evidence that the paternal environment plays a role in a non-genetic inheritance of pre-conceptional exposures through the male germ line...
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29732170/nutrition-meets-heredity-a-case-of-rna-mediated-transmission-of-acquired-characters
#5
Minoo Rassoulzadegan, François Cuzin
RNA-based inheritance provides a reasonable hypothesis to explain multigenerational maintenance of the disease in the progeny of either a male or female parent suffering from the metabolic syndrome (obesity and type 2 diabetes) induced by abnormal diet. Although, it is still difficult to formulate a complete rational mechanism, study of inheritance is a most direct way to learn about the epigenetic control of gene expression and we wished to summarised our current approach along this line.
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29732169/does-cross-generational-epigenetic-inheritance-contribute-to-cultural-continuity
#6
Marcus E Pembrey
Human studies of cross-generational epigenetic inheritance have to consider confounding by social patterning down the generations, often referred to as 'cultural inheritance'. This raises the question to what extent is 'cultural inheritance' itself epigenetically mediated rather than just learnt. Human studies of non-genetic inheritance have demonstrated that, beyond foetal life, experiences occurring in mid-childhood before puberty are the most likely to be associated with cross-generational responses in the next generation(s)...
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29732168/endocrine-disrupting-chemicals-epigenetics-and-skeletal-system-dysfunction-exploration-of-links-using-bisphenol-a-as-a-model-system
#7
Frances Xin, Lauren M Smith, Martha Susiarjo, Marisa S Bartolomei, Karl J Jepsen
Early life exposures to endocrine-disrupting chemicals (EDCs) have been associated with physiological changes of endocrine-sensitive tissues throughout postnatal life. Although hormones play a critical role in skeletal growth and maintenance, the effects of prenatal EDC exposure on adult bone health are not well understood. Moreover, studies assessing skeletal changes across multiple generations are limited. In this article, we present previously unpublished data demonstrating dose-, sex-, and generation-specific changes in bone morphology and function in adult mice developmentally exposed to the model estrogenic EDC bisphenol A (BPA) at doses of 10 μg (lower dose) or 10 mg per kg bw/d (upper dose) throughout gestation and lactation...
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29732167/bugs-in-the-program-can-pregnancy-drugs-and-smoking-disturb-molecular-reprogramming-of-the-fetal-germline-increasing-heritable-risk-for-autism-and-neurodevelopmental-disorders
#8
Jill Escher
In a seeming paradox, the prevalence of autism spectrum disorder (ASD) has surged, while at the same time research has pointed to the strong heritability of this neurodevelopmental pathology. Here an autism research philanthropist suggests a biological phenomenon of exogenously induced 'gamete disruption' that could reconcile these seemingly contradictory observations. Mining information from her own family history and that of her fellow autism parents, while also engaging with the scientific community, she proposes that a subset of the autisms may be rooted in a variety of molecular glitches in parental gametes induced by certain acute exposures during the parents' own fetal or neonatal development...
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29765770/persistent-6-oh-bde-47-exposure-impairs-functional-neuronal-maturation-and-alters-expression-of-neurodevelopmentally-relevant-chromatin-remodelers
#9
Robert G Poston, Carissa J Dunn, Pushpita Sarkar, Ramendra N Saha
Polybrominated diphenyl ethers (PBDEs) are a pervasive class of brominated flame retardants that are present in the environment at particularly high levels, especially in the United States. Their environmental stability, propensity for bioaccumulation, and known potential for neurotoxicity has evoked interest regarding their effects on the developing nervous system. Exposure to PBDEs has been strongly associated with neurodevelopmental disorders. However, the details of their mechanistic roles in such disorders are incompletely understood...
January 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29692927/-environmental-epigenetics-update
#10
EDITORIAL
Michael K Skinner
No abstract text is available yet for this article.
January 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29686887/role-of-dna-methylation-in-altered-gene-expression-patterns-in-adult-zebrafish-danio-rerio-exposed-to-3-3-4-4-5-pentachlorobiphenyl-pcb-126
#11
Neelakanteswar Aluru, Sibel I Karchner, Keegan S Krick, Wei Zhu, Jiang Liu
There is growing evidence that environmental toxicants can affect various physiological processes by altering DNA methylation patterns. However, very little is known about the impact of toxicant-induced DNA methylation changes on gene expression patterns. The objective of this study was to determine the genome-wide changes in DNA methylation concomitant with altered gene expression patterns in response to 3, 3', 4, 4', 5-pentachlorobiphenyl (PCB126) exposure. We used PCB126 as a model environmental chemical because the mechanism of action is well-characterized, involving activation of aryl hydrocarbon receptor, a ligand-activated transcription factor...
January 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29492318/a-phenotypic-hangover-the-predictive-adaptive-response-and-multigenerational-effects-of-altered-nutrition-on-the-transcriptome-of-drosophila-melanogaster
#12
Amy J Osborne, Peter K Dearden
The Developmental Origins of Health and Disease hypothesis predicts that early-life environmental exposures can be detrimental to later-life health and that mismatch between the pre- and post-natal environment may contribute to the growing non-communicable disease epidemic. Within this is an increasingly recognized role for epigenetic mechanisms; for example, epigenetic modifications can be influenced by nutrition and can alter gene expression in mothers and offspring. Currently, there are few whole-genome transcriptional studies of response to nutritional alteration...
October 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29492317/multigenerational-analysis-of-sex-specific-phenotypic-differences-at-midgestation-caused-by-abnormal-folate-metabolism
#13
Nisha Padmanabhan, Joanna Rakoczy, Monika Kondratowicz, Katerina Menelaou, Georgina E T Blake, Erica D Watson
The exposure to adverse environmental conditions (e.g. poor nutrition) may lead to increased disease risk in an individual and their descendants. In some cases, the results may be sexually dimorphic. A range of phenotypes has been associated with deficiency in or defective metabolism of the vitamin folate. However, the molecular mechanism linking folate metabolism to development is still not well defined nor is it clear whether phenotypes are sex-specific. The enzyme methionine synthase reductase (MTRR) is required for the progression of folate metabolism and the utilization of methyl groups from the folate cycle...
October 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29119010/epigenetic-impact-of-endocrine-disrupting-chemicals-on-lipid-homeostasis-and-atherosclerosis-a-pregnane-x-receptor-centric-view
#14
Robert N Helsley, Changcheng Zhou
Despite the major advances in developing diagnostic techniques and effective treatments, atherosclerotic cardiovascular disease (CVD) is still the leading cause of mortality and morbidity worldwide. While considerable progress has been achieved to identify gene variations and environmental factors that contribute to CVD, much less is known about the role of "gene-environment interactions" in predisposing individuals to CVD. Our chemical environment has significantly changed in the last few decades, and there are more than 100,000 synthetic chemicals in the market...
October 1, 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29492316/environment-epigenetics-and-reproduction
#15
Michael K Skinner
A conference summary of the third biannual Kenya Africa Conference "Environment, Epigenetics and Reproduction" is provided. A partial special Environmental Epigenetics issue containing a number of papers in Volume 3, Issue 3 and 4 are discussed.
July 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29492315/maintenance-of-mest-imprinted-methylation-in-blastocyst-stage-mouse-embryos-is-less-stable-than-other-imprinted-loci-following-superovulation-or-embryo-culture
#16
REVIEW
Brenna A M Velker, Michelle M Denomme, Robert T Krafty, Mellissa R W Mann
Assisted reproductive technologies are fertility treatments used by subfertile couples to conceive their biological child. Although generally considered safe, these pregnancies have been linked to genomic imprinting disorders, including Beckwith-Wiedemann and Silver-Russell Syndromes. Silver-Russell Syndrome is a growth disorder characterized by pre- and post-natal growth retardation. The Mest imprinted domain is one candidate region on chromosome 7 implicated in Silver-Russell Syndrome. We have previously shown that maintenance of imprinted methylation was disrupted by superovulation or embryo culture during pre-implantation mouse development...
July 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29492314/an-overview-of-a-sertoli-cell-transplantation-model-to-study-testis-morphogenesis-and-the-role-of-the-sertoli-cells-in-immune-privilege
#17
REVIEW
Gurvinder Kaur, Scott Vadala, Jannette M Dufour
Advanced testicular germ cells, expressing novel cell surface and intracellular proteins, appear after the establishment of central tolerance and thus are auto-immunogenic. However, due to testis immune privilege these germ cells normally do not evoke a detrimental immune response. The Sertoli cell (SC) barrier (also known as the blood-testis barrier) creates a unique microenvironment required for the completion of spermatogenesis and sequesters the majority of the advanced germ cells from the immune system...
July 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29492313/transgenerational-epigenetics-and-environmental-justice
#18
REVIEW
Mark A Rothstein, Heather L Harrell, Gary E Marchant
Human transmission to offspring and future generations of acquired epigenetic modifications has not been definitively established, although there are several environmental exposures with suggestive evidence. This article uses three examples of hazardous substances with greater exposures in vulnerable populations: pesticides, lead, and diesel exhaust. It then considers whether, if there were scientific evidence of transgenerational epigenetic inheritance, there would be greater attention given to concerns about environmental justice in environmental laws, regulations, and policies at all levels of government...
July 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29492312/exposure-to-phthalate-esters-induces-an-autophagic-response-in-male-germ-cells
#19
Paula Valenzuela-Leon, Ina Dobrinski
Phthalate esters are plasticizers that impart flexibility to polvinylchloride plastics. As they are not covalently bound, they can leach from a wide range of products, including food containers, medical devices, clothing, and toys, leading to widespread environmental exposure. Phthalate toxicity has been linked to male infertility by disrupting testosterone production and testis development. Phthalates also impair proliferation and viability of spermatogonial stem cells (SSC), the role of which is to support lifelong spermatogenesis...
July 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29147574/generational-comparisons-f1-versus-f3-of-vinclozolin-induced-epigenetic-transgenerational-inheritance-of-sperm-differential-dna-methylation-regions-epimutations-using-medip-seq
#20
Daniel Beck, Ingrid Sadler-Riggleman, Michael K Skinner
Environmentally induced epigenetic transgenerational inheritance of disease and phenotypic variation has been shown to involve DNA methylation alterations in the germline (e.g. sperm). These differential DNA methylation regions (DMRs) are termed epimutations and in part transmit the transgenerational phenotypes. The agricultural fungicide vinclozolin exposure of a gestating female rat has previously been shown to promote transgenerational disease and epimutations in F3 generation (great-grand-offspring) animals...
July 2017: Environmental Epigenetics
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