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Clinical Hypertension

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https://www.readbyqxmd.com/read/29713495/high-out-of-clinic-blood-pressure-is-associated-with-adiposity-indicators-in-leisure-physical-activity-practitioners-in-midwest-brazil
#1
Bruna M Giglio, Renata C Fernandes, Ana B Marini, João F Mota, Gustavo D Pimentel
Background: Several diseases, such as obesity, hypertension and type 2 diabetes are frequently associated with metabolic abnormalities, high costs of healthcare and morbi-mortality; thus the aim of this study was to investigate the relationship between out-of-clinic high blood pressure and chronic disease-associated adiposity indicators in practitioners of leisure physical activity. Methods: A cross-sectional study with 414 subjects of both genders aged 24-65 years...
2018: Clinical Hypertension
https://www.readbyqxmd.com/read/29636986/differences-in-self-reported-weekend-catch-up-sleep-between-children-and-adolescents-with-and-without-primary-hypertension
#2
Neena Gupta, Louise Maranda, Rakesh Gupta
Background: The data on the association of sleep duration and blood pressure in the pediatric age group have been mixed and most studies have focused on weekday sleep duration. The purpose of this study was to compare the weekday and weekend sleep patterns between children and adolescents with newly diagnosed primary hypertension and a normotensive control group. Methods: Children and adolescents from a pediatric nephrology clinic, aged 6-18 years with newly diagnosed primary hypertension were compared to an age and sex matched normotensive control group from a general pediatric clinic...
2018: Clinical Hypertension
https://www.readbyqxmd.com/read/29632702/knowledge-attitudes-and-practices-of-hypertensive-patients-towards-prevention-and-early-detection-of-chronic-kidney-disease-a-cross-sectional-study-from-palestine
#3
Hala H Sa'adeh, Razan N Darwazeh, Amani A Khalil, Sa'ed H Zyoud
Background: Hypertension is the second most common cause of chronic kidney disease (CKD). Therefore, the aims of the study were to assess the knowledge, attitudes and practices (KAP) of hypertensive patients towards prevention and early detection of CKD, and to determine the clinical and socio-demographic factors, which affect the KAP regarding prevention of CKD. Methods: A cross-sectional study was held using the CKD screening Index to assess the KAP of 374 hypertensive patients who were selected from multiple primary healthcare centers in Nablus, Palestine...
2018: Clinical Hypertension
https://www.readbyqxmd.com/read/29568571/analysis-of-cytomegalovirus-specific-t-cell-responses-in-patients-with-hypertension-comparison-of-assay-methods-and-antigens
#4
Jong-Chan Youn, Jun Yong Kim, Min Kyung Jung, Hee Tae Yu, Su-Hyung Park, In-Cheol Kim, Sun Ki Lee, Suk-Won Choi, Seongwoo Han, Kyu-Hyung Ryu, Sungha Park, Eui-Cheol Shin
Background: Recent studies suggest an association between cytomegalovirus (CMV) infection and hypertension. In the present study, we used a variety of antigens and different assay methods to investigate the relationship between CMV-specific T-cell responses and arterial stiffness in patients with hypertension. Methods: To evaluate arterial stiffness, pulse wave velocity (PWV) was measured in 207 hypertensive patients (average age, 63 ± 8 years). To measure CMV pp65 and IE-1-specific T-cell responses, we performed intracellular cytokine staining (ICS) and enzyme-linked immunospot (ELISPOT) assays...
2018: Clinical Hypertension
https://www.readbyqxmd.com/read/29507752/chlorthalidone-not-hydrochlorothiazide-is-the-right-diuretic-for-comparison
#5
Ravi Tejraj Mehta, Anil Pareek, Indranil Purkait
We have read the study design "Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active controlled, phase 4, randomized trial" by Oh GC, et al. with interest. The authors aim to compare the efficacy of amlodipine or hydrochlorothiazide (HCTZ) with an ARB. However, we wish to highlight that chlorthalidone (CTD) is the evidence-based and recommended anti-hypertensive diuretic, and should replace HCTZ in the trial to effectively compare efficacy against the CCB amlodipine...
2018: Clinical Hypertension
https://www.readbyqxmd.com/read/29468088/neck-circumference-is-independently-associated-with-relative-systemic-hypertension-in-young-adults-with-sickle-cell-anaemia
#6
Lawrence A Olatunji, Olatunde P Olabode, Olawale M Akinlade, Abiola S Babatunde, Victoria A Olatunji, Ayodele O Soladoye
Background: A seemingly interesting observation in patients with sickle cell anaemia (SCA) is that they usually have lower systemic blood pressures (BP) and insulin resistance than persons in the general population in spite of chronic inflammation and vasculopathy. However, relative systemic hypertension (rHTN) has been linked to pulmonary hypertension, increased blood viscosity and renal insufficiency, which could indicate a risk of developing cardiometabolic disorder (CMD) in SCA.We therefore hypothesized that neck circumference (NC) and CMD marker; triglyceride glucose (TyG) index would independently predict rHTN in young adults with SCA in steady state...
2018: Clinical Hypertension
https://www.readbyqxmd.com/read/29445520/efficacy-and-safety-of-azilsartan-medoxomil-an-angiotensin-receptor-blocker-in-korean-patients-with-essential-hypertension
#7
Attila Juhasz, Jingtao Wu, Michie Hisada, Tomoka Tsukada, Myung Ho Jeong
Background: This was a phase 3, randomized, double-blind, placebo-controlled study. Methods: Adult Korean patients with essential hypertension and a baseline mean sitting clinic systolic blood pressure (scSBP) ≥150 and ≤180 mmHg were randomized to 6-week treatment with placebo ( n  = 65), azilsartan medoxomil (AZL-M) 40 mg ( n  = 132), or AZL-M 80 mg ( n  = 131). The primary endpoint was the change from baseline to week 6 in trough scSBP. Results: The least-squares mean (standard error) change from baseline in trough scSBP in the placebo, AZL-M 40-mg, and 80-mg groups at week 6 were - 8...
2018: Clinical Hypertension
https://www.readbyqxmd.com/read/29423268/interaction-between-body-mass-index-and-serum-uric-acid-in-relation-to-blood-pressure-in-community-dwelling-japanese-men
#8
Ryuichi Kawamoto, Daisuke Ninomiya, Kensuke Senzaki, Teru Kumagi
Background: Few data is available on the association between body mass index (BMI), serum uric acid (SUA) levels and blood pressure (BP) categories in the disease continuum, when efforts for its prevention may be applicable. Methods: We performed a cross-sectional study to examine the association between BMI, SUA and BP in a community-dwelling sample of Japanese men. Individuals not on antihypertensive and uric acid lowering medications, and aged 50 to 90 years [817men aged 66 ± 9 (mean ± standard deviation) years] were recruited for the survey during a community based annual medical check-up...
2018: Clinical Hypertension
https://www.readbyqxmd.com/read/29299337/blood-pressure-control-and-its-determinants-among-diabetes-mellitus-co-morbid-hypertensive-patients-at-jimma-university-medical-center-south-west-ethiopia
#9
Sintayehu Muleta, Tsegaye Melaku, Legese Chelkeba, Desta Assefa
Background: Hypertension is the major contributor to cardiovascular diseases related morbidity and mortality. Blood pressure is not well controlled in the majority of patients with both diabetes and hypertension. The main objective of this study was to assess blood pressure control and its determinants among diabetes mellitus co- morbid hypertensive ambulatory patients. Methods: Hospital based cross sectional study was conducted among diabetes mellitus co-morbid hypertensive ambulatory adult patients based on the inclusion criteria...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29299336/systolic-time-ratio-measured-by-impedance-cardiography-accurately-screens-left-ventricular-diastolic-dysfunction-in-patients-with-arterial-hypertension
#10
Rodrigo Nazário Leão, Pedro Marques Silva, Luísa Branco, Helena Fonseca, Bruno Bento, Marta Alves, Daniel Virella, Roberto Palma Reis
Background: The use of impedance cardiography (ICG) may play a role in the assessment of cardiac effects of hypertension (HT), especially its hemodynamic features. Hypertensive heart disease involves structural changes and alterations in left ventricular geometry that end up causing systolic and/or diastolic dysfunction. The IMPEDDANS study aims to assess the usefulness of ICG for the screening of left ventricular diastolic dysfunction (LVDD) in patients with HT. Methods: Patients with HT were assessed by echocardiography and ICG...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29238609/blunted-heart-rate-recovery-is-associated-with-coronary-artery-spasm-in-patients-with-suspected-vasospastic-angina
#11
Hyunsu Kim, Sang-Hoon Cho, Kyoung-Im Cho, Bong-Joon Kim, Sung-Il Im, Jung-Ho Heo
Background: Autonomic nervous system activity has been shown to be altered in patients with vasospastic angina (VA). Heart rate recovery (HRR) is a simple, non-invasive measurement of autonomic nervous system dysfunction. We aimed to investigate whether HRR is related to VA, as established by an ergonovine test. Methods: A total of 976 consecutive patients (47.5% male, mean age 55 years) without significant coronary artery disease who underwent both an ergonovine provocation test and a treadmill exercise test were enrolled...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29234523/amlodipine-vs-hydrochlorothiazide-is-there-any-disparity-in-its-antihypertensive-effect-or-not
#12
Venu Gopal Jonnalagadda, Kanchan Choudhary, Vijay Kranti Matety
We have read the article "Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active controlled, phase 4, randomized trial" by GC Oh., et al. and found it quite interesting to learn the testing of effectiveness between amlodipine and hydrochlorothiazide in combination with losartan. After 4 weeks of therapy, non-responders were exposed for dose titration of losartan/amlodipine 100/5 mg daily or losartan/hydrochlorothiazide 100/25 mg daily...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29225914/status-of-hypertension-screening-in-the-korea-national-general-health-screening-program-a-questionnaire-survey-on-210-screening-centers-in-two-metropolitan-areas
#13
Seung Won Lee, Hae-Young Lee, Sang Hyun Ihm, Sung Ha Park, Tae Hyun Kim, Hyeon Chang Kim
Background: The purpose of this survey was to evaluate the performance of hypertension screening in medical institutions conducting the national general health screening program of the Republic of Korea. Methods: We contacted 700 medical institutions of Seoul and Incheon areas which performed the national general health screening program in 2016, and 210 of them completed telephone survey. The questions asked in the survey include equipment, environment, personnel and quality control procedures for blood pressure (BP) measurement, and interpretation of the measurements...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29214054/lifestyle-modification-practice-and-associated-factors-among-diagnosed-hypertensive-patients-in-selected-hospitals-south-ethiopia
#14
Eyasu Siyum Buda, Lolemo Kelbiso Hanfore, Robera Olana Fite, Alula Seyum Buda
Background: Hypertension is one of the leading causes of disability and death in both developed and developing countries that need urgent strategies to implement interventions that control it. Appropriate lifestyle changes often called non-pharmacological approaches that often overlooked are the corner stone of the prevention and control of hypertension. The aim of this study is to assess the practice of lifestyle modifications and associated factors among diagnosed hypertensive patients in Durame and Nigist Elleni Mohamed Memorial General Hospitals in southern Ethiopia...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29214053/severe-carvedilol-toxicity-without-overdose-caution-in-cirrhosis
#15
Satish Maharaj, Karan Seegobin, Julio Perez-Downes, Belinda Bajric, Simone Chang, Pramod Reddy
Background: Carvedilol is used in the management of hypertension, ischemic heart disease, heart failure and most recently, portal hypertension. It has been associated with improved outcomes regarding variceal bleeding, hepatic decompensation and death when compared to propranolol and endoscopic band ligation. The main cause of portal hypertension is cirrhosis and therefore carvedilol is increasingly used in these patients. Due to its extensive hepatic metabolism, carvedilol is contraindicated in severe hepatic impairment...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29163986/the-salt-taste-threshold-in-untreated-hypertensive-patients
#16
Chang-Yeon Kim, Mi-Kyung Ye, Young Soo Lee
Background: The salt-taste threshold can influence the salt appetite, and is thought to be another marker of sodium intake. Many studies have mentioned the relationship between the sodium intake and blood pressure (BP). The aim of this study was to evaluate the relationship between the salt-taste threshold and urinary sodium excretion in normotensive and hypertensive groups. Methods: We analyzed 199 patients (mean age 52 years, male 47.3%) who underwent 24-h ambulatory BP monitoring (ABPM)...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29119005/differences-in-left-ventricular-functional-adaptation-to-arterial-stiffness-and-neurohormonal-activation-in-patients-with-hypertension-a-study-with-two-dimensional-layer-specific-speckle-tracking-echocardiography
#17
Darae Kim, Chi Young Shim, Geu-Ru Hong, Sungha Park, InJeong Cho, Hyuk-Jae Chang, Jong-Won Ha, Namsik Chung
Background: Arterial stiffness increases pressure load to the left ventricle (LV), leading to LV hypertrophy and subendocardial ischemia. Neurohormones stimulate myocardial fibrosis and LV dysfunction. We aimed to explore the associations of arterial stiffness and plasma aldosterone with multi-directional, layer-specific LV, and left atrial (LA) mechanical function in hypertensive patients. Methods: Layer-specific LV global longitudinal strain (GLS-trans, GLS-endo, GLS-epi), global circumferential strain (GCS-trans, GCS-endo, GCS-epi), LV torsional parameters, and LA global longitudinal strain (LA GLS) were analyzed by two-dimensional speckle tracking echocardiography in 195 hypertensive patients (110 men, mean age 55 years)...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29085669/identifying-treatment-response-to-antihypertensives-in-patients-with-obesity-related-hypertension
#18
Ilse M Schrover, Jannick A N Dorresteijn, Jodine E Smits, A H Jan Danser, Frank L J Visseren, Wilko Spiering
BACKGROUND: In patients with obesity-related hypertension (ORH), reaction to antihypertensive medication is likely influenced by patientcharacteristics. METHODS: Effects of aliskiren, moxonidine and hydrochlorothiazide on 24-h blood pressure (BP) were compared to placebo. Linear mixed effect models were used to analyze the effect of patient characteristics on BP levels and treatment response. RESULTS: Systolic BP response to aliskiren was higher in patients with a BMI > 30...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29026648/clinical-impact-of-skin-autofluorescence-on-high-sensitivity-troponin-t-in-hypertensive-patients
#19
Takashi Hitsumoto
BACKGROUND: Recent studies have reported the importance of high-sensitivity troponin T (hs-cTnT) or skin autofluorescence (AF) as a cardiovascular risk factor. However, little is known about the relationship between these two markers. The aim of this study was to clarify the clinical impact of skin AF on hs-cTnT in hypertensive patients, from the perspective of primary prevention of cardiovascular events. METHODS: In total, 457 outpatients on treatment for hypertension [182 men and 275 women; mean (± SD) age, 67 ± 13 y] and with no history of cardiovascular events were enrolled...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28879040/comparison-of-effects-between-calcium-channel-blocker-and-diuretics-in-combination-with-angiotensin-ii-receptor-blocker-on-24-h-central-blood-pressure-and-vascular-hemodynamic-parameters-in-hypertensive-patients-study-design-for-a-multicenter-double-blinded
#20
Gyu Chul Oh, Hae-Young Lee, Wook Jin Chung, Ho-Joong Youn, Eun-Joo Cho, Ki-Chul Sung, Shung Chull Chae, Byung-Su Yoo, Chang Gyu Park, Soon Jun Hong, Young Kwon Kim, Taek-Jong Hong, Dong-Ju Choi, Min Su Hyun, Jong Won Ha, Young Jo Kim, Youngkeun Ahn, Myeong Chan Cho, Soon-Gil Kim, Jinho Shin, Sungha Park, Il-Suk Sohn, Chong-Jin Kim
BACKGROUND: Hypertension is a risk factor for coronary heart disease and stroke, and is one of the leading causes of death. Although over a billion people are affected worldwide, only half of them receive adequate treatment. Current guidelines on antihypertensive treatment recommend combination therapy for patients not responding to monotherapy, but as the number of pills increase, patient compliance tends to decrease. As a result, fixed-dose combination drugs with different antihypertensive agents have been developed and widely used in recent years...
2017: Clinical Hypertension
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