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ACS Sensors

Fernando V Paulovich, Maria Cristina Ferreira de Oliveira, Osvaldo Novais Oliveira
In this paper we discuss the relevance of sensing and biosensing for the ongoing revolution in science and technology as a product of the merging of machine learning and Big Data into affordable technologies and accessible everyday products. Possible scenarios for the next decades are described with examples of intelligent systems for various areas, most of which will rely on ubiquitous sensing. The technological and societal challenges for developing the full potential of such intelligent systems are also addressed...
July 13, 2018: ACS Sensors
Soo-Yeon Cho, Kyeong Min Cho, Sanggyu Chong, Kangho Park, Sungtak Kim, Hohyung Kang, Seon Joon Kim, Geunjae Kwak, Jihan Kim, Hee-Tae Jung
Strong acidic gases such as CO2 , SO2 , and NO2 are harsh air pollutants with major human health threatening factors, and as such, developing new tools to monitor and to quickly sense these gases is critically required. However, it is difficult to selectively detect the acidic air pollutants with single channel material due to the similar chemistry shared by acidic molecules. In this work, three acidic gases (i.e., CO2 , SO2 , and NO2 ) are selectively discriminated using single channel material with precise moiety design...
July 10, 2018: ACS Sensors
Xin Li, Xinlei Wang, Lizhi Zhang, Jingming Gong
A unique split-type photoelectrochemical (PEC) immunoassay has been constructed for detection of low-abundant biocompounds (lysozyme, Lyz, used in this case) via a new trigger strategy by disintegrating bioconjugates of dopamine-grafted silica nanospheres (DA@SiO2NSs) for signal amplification. The preferred electron donor assembly of DA@SiO2NSs is first used as a molecular printboard for positioning anti-Lyz secondary antibody (Ab2) through an amide reaction. With specific immunoreactions in a high-binding microplate, a sandwich immunoassay, the DA@SiO2NSs-based bioconjugate is achieved...
July 9, 2018: ACS Sensors
Michael N Kammer, Amanda K Kussrow, Ian R Olmsted, Darryl J Bornhop
Here we report an improved interferometric sensing approach that facilitates high sensitivity refractive index (RI) measurements and molecular interaction assays without a temperature controller. The compensated backscattering interferometer (CBSI) is based on a Helium-Neon (He-Ne) laser, microfluidic chip, and a CCD array. CBSI enables simultaneous differential RI measurements within nanoliter volumes, at a compensation level of ca. 5×10-8 RIU in the presence of large thermal perturbations (8°C). This level of dn/dT compensation is enabled by elongating the laser beam along the central axis of the microfluidic channel and measuring the difference in positional shift of interference patterns from two adja-cent regions of the channel...
July 9, 2018: ACS Sensors
Henning Hoefig, Julia Otten, Victoria Steffen, Martina Pohl, Arnold J Boersma, Joerg Fitter
Genetically encoded FRET-based biosensors for the quantification of ligand molecules change the magnitude of Förster Resonance Energy Transfer (FRET) between two fluorescent proteins upon binding a target metabolite. When designing highly sensitive sensors extensive sensor optimization is essential. However, it is often difficult to verify the ideas of modifications made to a sensor during sensor optimization process due to the limited information content of ensemble FRET measurements. In contrast, single-molecule detection provides detailed information and higher accuracy...
July 6, 2018: ACS Sensors
Xiang Ren, Parham Ghassemi, Yasmine M Kanaan, Tammey Naab, Robert L Copeland, Robert L Dewitty, Inyoung Kim, Jeannine S Strobl, Masoud Agah
A high-throughput multi-constriction microfluidic channels device can distinguish human breast cancer cell lines (MDA-MB-231, HCC-1806, MCF-7) from immortalized breast cells (MCF-10A) with a confidence level of ~81-85% at a rate of 50-70 cells/min based on velocity increment differences through multi-constriction channels aligned in series. The results are likely related to the deformability differences between non-malignant and malignant breast cells. The data were analyzed by the methods/algorithms of Ridge, nonnegative garrote on kernel machine (NGK), and Lasso using high-dimensional variables, including the cell sizes, velocities and velocity increments...
July 6, 2018: ACS Sensors
Edwin En-Te Hwu, Anja Boisen
The optical pickup unit (OPU) within a CD/DVD/Blu-ray drive integrates 780, 650, and 405 nm wavelength lasers, diffraction-limited optics, a high-bandwidth optoelectronic transducer up to 400 MHz, and a nano-resolution x-, z-axis and tilt actuator in a compact size. In addition, the OPU is a remarkable piece of engineering and could enable different scientific applications such as sub-angstrom displacement sensing, micro and nanoimaging, and nanolithography. Although off-the-shelf OPUs can be easily obtained, manufacturers protect their datasheets under non-disclosure agreements to impede their availability to the public...
July 6, 2018: ACS Sensors
Wei Zhang, Mike B Dixon, Christopher P Saint, Kar Seng Teng, Hiroaki Furumai
Due to increasing stringency of water legislation and extreme consequences that failure to detect some contaminants in water can involve, there has been a strong interest in developing electrochemical biosensors for algal toxins detection during last decade, evidenced by literature increasing from 2 journal papers pre-2009 to 24 between 2009 and 2018. In this context, this review has summarised recent progress of successful algal toxin detection in water using electrochemical biosensing techniques. Satisfactory detection recoveries using real environmental water samples, good sensor repeatability and reproducibility have been achieved, along with some excellent limit-of-detection (LOD) reported...
July 5, 2018: ACS Sensors
Junchao Zhou, Pao Tai Lin
In-situ material identification and object tracking have been demonstrated using a mid-infrared (mid-IR) robotic scanning system. This detection method is capable of inspecting materials non-invasively because the mid-IR spectrum overlaps with numerous characteristic absorption bands corresponding to various chemical function groups. The scanning system consisted of a fiber probe connected to a mid-IR tunable laser with a wavelength tuning range of λ = 2.45 - 3.75 µm. To evaluate the high-speed performance of the scanning system, a testing platform was constructed with an object plate rapidly rotating at ω = 231 rpm...
July 4, 2018: ACS Sensors
Qing Zhou, Huaijia Xue, Yuye Zhang, Yanqin Lv, Hongguang Li, Songqin Liu, Yanfei Shen, Yuanjian Zhang
C60 can accept up to six electrons reversibly and show exceptional light absorption over the entire UV-vis spectrum, making it a potential photoactive probe for photoelectrochemical (PEC) bioassay. However, few successful works have been reported to apply fullerenes in PEC biosensing, partially because of the low electronic conductivity and poor interfacial interactions with targeted biomolecules. Herein, we report the addressing of these two obstacles by coupling high conductive graphite flake (Gr), graphene oxide (GO) with sufficient oxygen-containing functional groups, and an alkylated C60 (AC60) into a metal-free all-carbon nanohybrid (AC60-Gr-GO) via harnessing delicate non-covalent interactions among them through a facile mechanical grinding...
July 4, 2018: ACS Sensors
Tian Li, Xin Wang, Qixing Zhou, Chengmei Liao, Lean Zhou, Lili Wan, Jingkun An, Qing Du, Nan Li, Zhiyong Jason Ren
Acid rain poses significant threats to crops and causes a decline in food production, but current monitoring and response to acid rain damage is either slow or expensive. The direct damage observation on plants can take several hours to days when the damage is irreversible. This study presents a real time bioelectrochemical monitoring approach that can detect acid rain damage within minutes. The rhizospheric bioelectrochemical sensor (RBS) takes advantage of the fast chain responses from leaves to roots, and then to the microbial electrochemical reactions in the rhizosphere...
July 3, 2018: ACS Sensors
Ozlem Yavas, Srdjan S Acimovic, Jose Garcia-Guirado, Johann Berthelot, Paulina Dobosz, Vanesa Sanz, Romain Quidant
The need for point-of-care (POC) devices capable of early detecting diseases and monitoring their status, out of a lab environment, has stimulated the development of compact biosensing configurations. While Localized Surface Plasmon Resonance (LSPR) sensing integrated into a state-of-the-art microfluidic chip stands as a promising approach to meet this demand, its implementation into an operating sensing platform capable to detect quantitatively a set of molecular biomarkers in an unknown biological sample is only at its infancy...
June 27, 2018: ACS Sensors
Sagar M Doshi, Erik T Thostenson
A scalable electrophoretic deposition (EPD) approach is used to create novel thin, flexible and lightweight carbon nanotube-based textile pressure sensors. The pressure sensors can be produced using an extensive variety of natural and synthetic fibers. These piezoresistive sensors are sensitive to pressures ranging from the tactile range (< 10 kPa), in the body weight range (~ 500 kPa), and very high pressures (~40 MPa). The EPD technique enables the creation of a uniform carbon nanotube-based nanocomposite coating, in the range of 250-750 nm thick, of polyethyleneimine (PEI) functionalized carbon nanotubes on non-conductive fibers...
June 26, 2018: ACS Sensors
Xinsheng Yang, Dongmin Shi, Shengmei Zhu, Baojuan Wang, Xiaojun Zhang, Guangfeng Wang
Despite of some recent development on the portable sensor for the on-site detection of Aflatoxin B1 (AFB1), the complex and expensive preparation of recognition elements still limited their wide applications. In this paper, by the fast, low-cost and stable recognition of aptamer DNA-AFB1, a portable aptasensor was fabricated for the on-site sensitive detection of the AFB1 in food matrixes, with the personal glucose meter (PGM) as readout and DNA walking machine for signal probe separation. In such an assay protocol, the target could trigger the DNA walker autonomously moving on the electrode surface, propelled by unidirectional Pb2+-specific DNAzyme digestion, which could amplify the signal and separate the signal probe as well for further quantification by the PGM...
June 26, 2018: ACS Sensors
Katherine E Boehle, Cody S Carrell, Joseph Caraway, Charles S Henry
Falsified and substandard antibiotics are a growing worldwide problem that leads to increased patient mortality and decreased trust in healthcare, and contributes to antimicrobial resistance. Monitoring falsified antibiotics is difficult because most falsified pharmaceuticals are most commonly found in developing countries, where detecting the active ingredient is difficult due to lack of access to complex instrumentation. Herein, we describe the development and optimization of a microfluidic paper-based analytical device (μPAD) to detect the active ingredient in the most falsified class of antibiotics, β-lactams...
June 26, 2018: ACS Sensors
Ningxing Li, Mingyuan Du, Yucheng Liu, Xinghu Ji, Zhike He
Two kinds of sensitive biosensors based on multi-pedal DNA walker along a 3-D DNA functional magnet particles track for the chemiluminescent detection of streptavidin are constructed and compared in this study. In the presence of SA, multi-pedal DNA walker has been constructed by biotin-modified catalyst as a result of the terminal protection for avoiding the digestion by exonuclease I. Then a toehold of CHA-H1 conjugated with magnetic microparticles (MMPs) could interact with a 'leg' of multi-pedal DNA walker to open the hairpin via toehold-mediated strand exchange catalysis...
June 25, 2018: ACS Sensors
Lorenzo Sansalone, Sicheng Tang, Jaume Garcia-Amorós, Yang Zhang, Santi Nonell, James D Baker, Burjor Captain, Françisco M Raymo
A mechanism to photoactivate far-red/near-infrared fluorescence with infinite contrast and under mild visible illumination was designed around the photophysical properties of borondipyrromethene (BODIPY) dyes and the photochemical behavior of oxazine heterocycles. Specifically, the photoinduced and irreversible cleavage of an oxazine ring with a laser line at 405 nm extends the electronic conjugation of a BODIPY chromophore over a 3 H-indole auxochrome with a 2-(4-methoxyphenyl)ethenyl substituent in position 5...
June 21, 2018: ACS Sensors
Jin-Wen Shangguan, Yu Liu, Sha Wang, Yun-Xuan Hou, Bi-Yi Xu, Jing-Juan Xu, Hong-Yuan Chen
The paper capillary is introduced to enable effective sampling on microfluidic paper analytical devices. By coupling the macroscale capillary force of paper capillary and the microscale capillary forces of native paper, fluid transport can be flexibly tailored with proper design. Subsequently, a hybrid-fluid-mode paper capillary device was proposed which enables fast and reliable sampling in an arrayed form with less surface adsorption and bias for different components. The resulting device thus supports high-throughput, quantitative, and repeatable assays by manual operation...
June 20, 2018: ACS Sensors
Najmeh Karimian, Angela Maria Stortini, Ligia Maria Moretto, Claudio Costantino, Sara Bogialli, Paolo Ugo
This work is aimed at developing an electrochemical sensor for the sensitive and selective detection of trace levels of perfluorooctane sulfonate (PFOS) in water. Contamination of waters by perfluorinated alkyl substances (PFAS) is a problem of global concern due to their suspected toxicity and ability to bioaccumulate. PFOS is the perfluorinated compound of major concern, as it has the lowest suggested control concentrations. The sensor reported here is based on a gold electrode modified with a thin coating of a molecularly imprinted polymer (MIP), prepared by anodic electropolymerization of o-phenylenediamine (o-PD) in the presence of PFOS as the template...
June 18, 2018: ACS Sensors
Xinglei Tao, Shenglong Liao, Shuqiang Wang, Di Wu, Yapei Wang
With the use of coordinated complex between aliphatic diols and calcium chloride (CaCl2) as green electrolytes, a body compatible, eco-friendly and low-cost thermometer is successfully developed. This particular conductive liquid possesses unique features of ultrafast response and high sensitivity against temperature change. The influences of CaCl2 concentra-tion and the category of aliphatic diols on conductivity change reveal that the thermal sensing abilities of such a kind of green electrolytes are positively relevant to the viscosity change along with temperature change...
June 15, 2018: ACS Sensors
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