Yang Liu, Shuangshuang Gao, Lixuan Liu, Ji Wang, Dapeng Wang, Jianyong Xiang, Anmin Nie, Kun Zhai, Congpu Mu, Fusheng Wen, Bochong Wang, Tianyu Xue, Zhongyuan Liu
Imaging the surface charge of biomolecules such as proteins and DNA, is crucial for comprehending their structure and function. Unfortunately, current methods for label-free, sensitive, and rapid imaging of the surface charge of single DNA molecules are limited. Here, we propose a plasmonic microscopy strategy that utilizes charge-sensitive single-crystal monolayer WS2 materials to image the local charge density of a single λ-DNA molecule. Our study reveals that WS2 is a highly sensitive charge-sensitive material that can accurately measure the local charge density of λ-DNA with high spatial resolution and sensitivity...
April 16, 2024: ACS Sensors