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ACS Sensors

Lu Lin, Peng Zhao, Andrew J Mason, Xiangqun Zeng
Electrochemical amperometric sensors require a constant or varying potential at the working electrode that drives redox reactions of the analyte for detection. The interfacial redox reaction(s) can result in the formation of new chemical products that could change the initial condition of the electrode/electrolyte interface. If the products are not inert and/or cannot be removed from the system or if the initial condition of the electrode/electrolyte interface cannot be restored, the sensor signal baseline would consequently drift which is problematic for the continuous and real-time sensors...
May 21, 2018: ACS Sensors
Samantha E McBirney, Dongyu Chen, Alexis Scholtz, Hossein Ameri, Andrea M Armani
Despite significant success in therapeutic development, malaria remains a widespread and deadly infectious disease in the developing world. Given the nearly 100% efficacy of current malaria therapeutics, the primary barrier to eradication is lack of early diagnosis of the infected population. However, there are multiple strains of malaria. Although significant efforts and resources have been invested in developing antibody-based diagnostic methods for Plasmodium falciparum, a rapid and easy to use screening method capable of detecting all malaria strains has not been realized...
May 21, 2018: ACS Sensors
Aditya Aryasomayajula, Caroline Wojnas, Ranjith Divigalpitiya, Ponnambalam Ravi Selvaganapathy, Peter Kruse
No abstract text is available yet for this article.
May 18, 2018: ACS Sensors
Yi-Hsin Tai, Chia-Wei Lee, Dao-Ming Chang, Yu-Sheng Lai, Ding-Wei Huang, Pei-Kuen Wei
A sensitive tapered optical fiber tip combined with dielectrophoretic (DEP) trapping was used to rapid and label-free detection of bacteria in water. The angular spectrum of optical field at the fiber tip was changed with surrounding refractive index (RI). By measuring far-field intensity change at the defocus plane, the intensity sensitivity was up to 95,200 %/RIU (RI unit) and the detection limit was 2.1 × 10-6 RIU at 0.2% intensity stability. By applying an AC voltage to a Ti/Al coated fiber tip and an indium-tin-oxide glass, the DEP force effectively trapped the Escherichia coli (E...
May 17, 2018: ACS Sensors
Nianzu Liu, Ni Hui, Jason J Davis, Xiliang Luo
The construction of sensitive and selective biosensors capable of detecting specific targets in complex biological samples remains a challenge highly relevant to a range of sensor/diagnostic applications. Herein, we have utilized a multifunctional peptide to present an interface that supports the very specific recruitment of targets from serum. The novel peptide sequence designed contains an anchoring domain (CPPPP-), an antifouling domain (-NQNQNQNQDHWRGWVA) and a human immunoglobulin G (IgG) recognition domain (-HWRGWVA), and the whole peptide was designed to be antifouling...
May 17, 2018: ACS Sensors
Genggongwo Shi, Taeseung Yoon, Seoncheol Cha, Seulgi Kim, Muhammad Yousuf, Nisar Ahmed, Doseok Kim, Hyun-Wook Kang, Kwang S Kim
Water-soluble, carbazole-based two-photon excitable fluorescent probes MPVC-I ("turn-on") and MPVC-II ("turn-off") are rationally designed and synthesized for the selective monitoring of carbon monoxide (CO). Both probes can effectively measure carboxyhemoglobin (HbCO) in the blood of the animals exposed to a CO dose as low as 100 ppm for 10 min. The palladium catalyzed azidocarbonylation reaction was optimized to improve the sensing efficiency.
May 16, 2018: ACS Sensors
Xiaofei Zhu, Yinhui Ju, Jian Chen, Deye Liu, Hong Liu
We report a non-enzymatic wearable sensor for electrochemical analysis of perspiration glucose. Multi-potential steps are applied on a Au electrode, including a high negative pretreatment potential step for proton reduction which produc-es a localized alkaline condition, a moderate potential step for electrocatalytic oxidation of glucose under the alkaline condi-tion, and a positive potential step to clean and reactivate the electrode surface for the next detection. Fluorocarbon-based materials were coated on the Au electrode for improving the selectivity and robustness of the sensor...
May 16, 2018: ACS Sensors
Steven M Russell, Roberto de la Rica
Meeting policy requirements is essential for advancing molecular diagnostic devices from the laboratory to real-world applications and commercialization. Considering policy as a starting point in the design of new technology is a winning strategy. Rapid developments have put mobile biosensors at the frontier of molecular diagnostics, at times outpacing policymakers, and therefore offering new opportunities for breakthroughs in global health. In this manuscript we survey influential global health policies and recent developments in mobile biosensing in order to gain a new perspective for the future of the field...
May 16, 2018: ACS Sensors
Mirelis Santos-Cancel, Robert Alexander Lazenby, Ryan J White
In this manuscript, we employ the technique intermittent pulse amperometry (IPA) to interrogate equilibrium and kinetic target binding to the surface of electrochemical, aptamer-based (E-AB) sensors, achieving as fast as 2 ms time resolution. E-AB sensors comprise an electrode surface modified with a flexible nucleic acid aptamer tethered at the 3'-terminus with a redox-active molecule. The introduction of a target changes the conformation and flexibility of the nucleic acid which alters the charge transfer rate of the appended redox molecule...
May 15, 2018: ACS Sensors
Dong-Ha Kim, Ji-Soo Jang, Won-Tae Koo, Seon-Jin Choi, Hee-Jin Cho, Min-Hyeok Kim, Sang-Joon Kim, Il-Doo Kim
Herein, we incorporated dual bio-templates, i.e., cellulose nanocrystals (CNC) and apoferritin into electrospinning solution to achieve three distinct benefits, i.e., (i) facile synthesis of WO3 nanotube by utilizing self-agglomerating nature of CNC in the core of as-spun nanofibers, (ii) effective sensitization by partial phase transition from WO3 to Na2W4O13 induced by interaction between sodium doped CNC and WO3 during calcination, and (iii) uniform functionalization with monodispersive apoferritin-derived Pt catalytic nanoparticles (2...
May 15, 2018: ACS Sensors
Mandana Amiri, Abolfazl Bezaatpour, Hamed Jafari, Rabah Boukherroub, Sabine Szunerits
Bacterial infections remain of the principal causes of morbidity and mortality worldwide. The number of death due to infections is declining every year by only 1% with a forecast of 13 million deaths in 2050. Among the 1400 recognized human pathogens, the majority of infectious diseases is caused by just a few, about 20 pathogens only. While the development of vaccinations and novel anti-bacterial drugs and treatments are at the forefront of research, and strongly financially supported by policy makers, another manner to limit and control infectious outbreaks is targeting the development and implementation of early warning systems, which indicate qualitatively and quantitatively the presence of a pathogen...
May 14, 2018: ACS Sensors
Jinbo Zhu, Zhiqiang Yan, Weijun Zhou, Chuanbo Liu, Jin Wang, Erkang Wang
Thioflavin T (ThT) was once regarded to be a specific fluorescent probe for the human telomeric G-quadruplex, but more other kinds of DNA were found that can also bind to ThT in recent years. Herein, we focus on G-rich parallel-stranded DNA and utilize fluorescence, absorbance, circular dichroism and surface plasmon resonance spectroscopy to investigate its interaction with ThT. Pyrene label and molecular modelling are applied to unveil the binding mechanism. We find a new class of non-G-quadruplex G-rich parallel-stranded (ps) DNA with the sequence of TG(GA)n can bind to ThT and increase the fluorescence with an enhancement ability superior to G-quadruplex...
May 11, 2018: ACS Sensors
Hnin Yin Yin Nyein, Li-Chia Tai, Quynh P Ngo, Minghan Chao, George Zhang, Wei Gao, Mallika Bariya, James Bullock, Hyungjin Kim, Hossain M Fahad, Ali Javey
Wearable sweat sensing is a rapidly rising research driven by its promising potential in health, fitness and diagnostic applications. Despite the growing field, major challenges in relation to sweat metrics remain to be addressed. These challenges include sweat rate monitoring for its complex relation with sweat compositions and sweat sampling for sweat dynamics studies. In this work, we present a flexible microfluidic sweat sensing patch that enhances real-time electrochemical sensing and sweat rate analysis via sweat sampling...
May 9, 2018: ACS Sensors
Emanuel Pfitzner, Hirofumi Seki, Ramona Schlesinger, Kenichi Ataka, Joachim Heberle
Plasmonic surfaces have emerged as a powerful platform for biomolecular sensing applications and can be designed to optimize the plasmonic resonance for probing molecular vibrations at utmost sensitivity. Here, we present a facile procedure to generate metallic micro disc antenna arrays that are employed in surface-enhanced infrared absorption (SEIRA) spectroscopy of biomolecules. Transmission electron microscopy (TEM) grids are used as shadow mask deployed during physical vapor deposition of gold. The resulting disc-shaped antennas exhibit enhancement factors of the vibrational bands of 4×104 giving rise to a detection limit < 1 femtomol (10-15 mol) of molecules...
May 9, 2018: ACS Sensors
Xingqing Xiao, Zhifeng Kuang, Joseph M Slocik, Sirimuvva Tadepalli, Michael Brothers, Steve S Kim, Peter A Mirau, Claire Butkus, Barry L Farmer, Srikanth Singamaneni, Carol K Hall, Rajesh R Naik
Sensors for human health and performance monitoring require biological recognition elements (BREs) at device interfaces for the detection of key molecular biomarkers that are measurable biological state indicators. BREs, including peptides, antibodies, and nucleic acids, bind to biomarkers in the vicinity of the sen-sor surface to create a signal proportional to the biomarker con-centration. The discovery of BREs with the required sensitivity and selectivity to bind biomarkers at low concentrations re-mains a fundamental challenge...
May 9, 2018: ACS Sensors
Siyu Qian, Ming Lin, Wei Ji, Huizhen Yuan, Yang Zhang, Zhenguo Jing, Jianzhang Zhao, Jean-François Masson, Wei Peng
MicroRNA (miRNA) regulates gene expression and plays fundamental roles in multiple biological processes. However, if both single strand RNA and DNA can bind with capture DNA on the sensing surface, selectively amplifying the complementary RNA signal is still challenging for researchers. Fiber-optic surface plasmon resonance (SPR) sensors are small, accurate and convenient tools for monitoring biological interaction. In this paper, we present a high sensitivity microRNA detection technique using phenylboronic acid functionalized Au nanoparticles (PBA-AuNPs) in fiber-optic SPR sensing system...
May 9, 2018: ACS Sensors
Dingkun Ren, Chi On Chui
Electric cell-substrate impedance sensing (ECIS) has been instrumental in tracking collective behavior of confluent cell layers for decades. Toward probing cellular heterogeneity in a population, the single-cell version of ECIS has also been explored, yet its intrinsic capability and limitation remain unclear. In this work, we argue for the fundamental feasibility of impedance spectroscopy to track changes of multiple cellular properties using a noninvasive single-cell approach. While changing individual properties is experimentally prohibitive, we take a simulation approach instead and mimic the corresponding changes using a 3D computational model...
May 8, 2018: ACS Sensors
Zhilong Song, Zhao Huang, Jingyao Liu, Zhixiang Hu, Jianbing Zhang, Guangzu Zhang, Fei Yi, Shenglin Jiang, Jiabiao Lian, Jia Yan, Jianfeng Zang, Huan Liu
Stretchable gas sensors that accommodate the shape and motion characteristics of human body are indispensable to a wearable or attachable smart sensing system. However, these gas sensors usually have poor response and recovery kinetics when operated at room temperature, especially suffer from humidity interference and mechanical robustness issues. Here, we demonstrate the first fully stretchable gas sensors which are operated at room temperature with enhanced stability against humidity. We created a crumpled quantum dot (QD) sensing layer on elastomeric substrate with flexible graphene as electrodes...
May 8, 2018: ACS Sensors
Siwakorn Sakunkaewkasem, Anuwut Petdum, Waraporn Panchan, Jitnapa Sirirak, Adisri Charoenpanich, Thanasat Sooksimuang, Nantanit Wanichacheva
A new fluorescent sensor, M201-DPA, based on [5]helicene derivative was utilized as dual-analyte sensor for determination of Cu2+ or Zn2+ in different media and different emission wavelengths. The sensor could provide selective and bifunctional determination of Cu2+ in HEPES buffer containing Triton-X100 and Zn2+ in Tris buffer/methanol without the interfering from each other and other ions. In HEPES buffer, M201-DPA demonstrated the selective ON-OFF fluorescence quenching at 524 nm toward Cu2+. On the other hand, in Tris buffer/methanol, M201-DPA showed the selective OFF-ON fluorescence enhancement upon the addition of Zn2+, which was specified by the hypsochromic shift at 448 nm...
May 7, 2018: ACS Sensors
Erik E Augspurger, Muhit Rana, Mehmet Veysel Yigit
Since the advent of its theoretical discovery more than 30 years ago, DNA nanotechnology has been used in a plethora of diverse applications in both the fundamental and applied sciences. DNA-based technologies' recent prominence in the scientific community is largely due to the programmable features stored in its nucleobase composition and sequence, which allow it to assemble into highly advanced structures. DNA nanoassemblies are also highly controllable due to the precision of natural and artificial base-pairing, which can be manipulated by pH, temperature, metal ions and solvent types...
May 7, 2018: ACS Sensors
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