Valdano Manuel, Leonardo A Miana, Miriam Helena Fonseca-Alaniz, Gabriel Carrillo Hernan, Davi Freitas Tenório, Celestino Bado, Mariana Lombardi Peres de Carvalho, Matheus Meirelles, João Paulo Mota Telles, Juliano Gomes Penha, Carla Tanamati, Luiz Fernando Caneo, José Eduardo Krieger, Fábio Biscegli Jatene, Marcelo Biscegli Jatene
BACKGROUND: The neutrophil-lymphocyte ratio (NLR) is an easily accessible and inexpensive biomarker that has been shown to predict morbidity and mortality in congenital cardiac surgery. However, its regulatory mechanism remains unclear. This study aims to compare and correlate the tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, and IL-10 messenger RNAs (mRNAs) with the NLR in patients with tetralogy of Fallot (ToF) and ventricular septal defect (VSD). METHODS: A prospective translational study was conducted on 10 children with ToF and 10 with VSD, aged between 1 and 24 months...
February 29, 2024: Translational Pediatrics