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Journal of Pharmaceutical Health Care and Sciences

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https://www.readbyqxmd.com/read/29619240/comparison-of-petinia-and-lc-ms-ms-for-determining-plasma-mycophenolic-acid-concentrations-in-japanese-lung-transplant-recipients
#1
Masafumi Kikuchi, Masaki Tanaka, Shinya Takasaki, Akiko Takahashi, Miki Akiba, Yasushi Matsuda, Masafumi Noda, Kanehiko Hisamichi, Hiroaki Yamaguchi, Yoshinori Okada, Nariyasu Mano
Background: Mycophenolic acid (MPA) treatment requires therapeutic drug monitoring to improve the outcome after organ transplantation. The aim of this study was to compare two methods, a particle enhanced turbidimetric inhibition immunoassay (PETINIA) and a reference liquid chromatography tandem mass spectrometry (LC-MS/MS) for determining plasma MPA concentrations from Japanese lung transplant recipients. Methods: Plasma MPA concentrations were determined from 20 Japanese lung transplant recipients using LC-MS/MS and the PETINIA on the Dimension Xpand Plus-HM analyzer...
2018: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29568540/developmental-changes-of-fluconazole-clearance-in-neonates-and-infants-in-relation-to-ontogeny-of-glomerular-filtration-rate-literature-review-and-data-analysis
#2
Kazutoshi Murakoso, Ryoichi Minagawa, Hirotoshi Echizen
Background: Fluconazole is frequently prescribed for the treatment of systemic fungal infection in neonates and infants. At present, prediction of fluconazole doses according to developmental changes in fluconazole clearance is not being done in these patients. We aimed to formulate a developmental model of fluconazole clearance taking into account the ontogeny of renal function, since the drug is largely eliminated renally. Methods: We systematically retrieved the data of fluconazole pharmacokinetics and renal function in children and adults from databases (MEDLINE and Japan Medical Abstracts Society)...
2018: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29564146/the-adoption-of-generic-drugs-by-a-hospital-effects-on-drug-dispensation-among-community-pharmacies
#3
Tomoya Tachi, Kosuke Saito, Hiroki Esaki, Ikuto Sugita, Aki Yoshida, Yuta Kanematsu, Yoshihiro Noguchi, Michi Umeda, Masahiro Yasuda, Takashi Mizui, Teruo Tsuchiya, Chitoshi Goto, Hitomi Teramachi
Background: The objective of the current study is to elucidate the effect that the adoption of generic drugs by a large hospital has on the dispensation of generic drugs by community pharmacies. We evaluated the percentage of generic drugs dispensed by pharmacies and the cost of drugs dispensed before and after the adoption of generic drugs by a large hospital. Methods: Participants comprised patients who were admitted to Gifu Municipal Hospital prior to its adoption of generic drugs (November 1, 2013 to November 14, 2013) and after its adoption (November 1, 2014 to November 14, 2014) and who utilized generic drugs dispensed by pharmacies...
2018: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29507747/new-low-dose-liquid-pilocarpine-formulation-for-treating-dry-mouth-in-sj%C3%A3-gren-s-syndrome-clinical-efficacy-symptom-relief-and-improvement-in-quality-of-life
#4
Machiko Watanabe, Chisato Yamada, Yoshinori Komagata, Hirotoshi Kikuchi, Hiroyuki Hosono, Fumio Itagaki
Background: Patients with Sjögren's syndrome (SS) typically present clinically with xerostomia (dry mouth) because of progressive damage to the exocrine glands. We developed a new, low-dose pilocarpine/sodium alginate (LPA) solution with pilocarpine hydrochloride to inhibit systemic adverse effects by administering via the oral mucosa. The purpose of this study was to assess its stability, safety, and efficacy. Methods: The pilocarpine concentration in an LPA liquid formulation was measured 3, 7, 14, and 28 days after preparation to assess its stability...
2018: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29445512/changes-in-tear-volume-and-ocular-symptoms-of-patients-receiving-oral-anticancer-drug-s-1
#5
Reiko Kuriki, Tsuyoshi Hata, Kinuyo Nakayama, Yuichi Ito, Kazunari Misawa, Seiji Ito, Michiko Tatematsu, Norio Kaneda
Background: Most eye disorders are not fatal but may deteriorate the quality of life of a patient. The eye disorder that is most frequently reported in the cancer chemotherapy is associated with the combination of tegafur/gimeracil/potassium oxonate (S-1). However, preventive methods or treatment methods for the eye disorder have not yet been established. This study aimed to determine changes in tear volume and subjective ocular symptoms during the treatment period in patients receiving S-1 monotherapy for early detection of adverse effects in the eye and establishment of its treatment methods...
2018: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29375887/a-questionnaire-survey-of-pharmacists-regarding-the-clinical-practice-guidelines-for-the-appropriate-use-of-granulocyte-colony-stimulating-factors
#6
Tetsuya Sasaki, Yasuhisa Kato, Atsushi Sato, Noriko Usui, Eishi Baba, Toshimi Takano, Nobuyuki Susumu, Kazunori Ohnishi, Hitomi Nishimoto, Katsuyuki Kiura
Background: Clinical practice guidelines should be user-friendly and confirming their penetration rate and compliance are critical. Methods: We conducted a nationwide web-based questionnaire survey among pharmacists regarding the 2013 guidelines for the appropriate use of granulocyte-colony stimulating factors (G - CSFs) (version 2, published by the Japan Society of Clinical Oncology [JSCO]) between August 24 and September 6, 2015. Results: A total of 301 pharmacists responded; 96...
2018: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29345696/antiemetic-efficacy-and-safety-of-granisetron-or-palonosetron-alone-and-in-combination-with-a-corticosteroid-for-abvd-therapy-induced-nausea-and-vomiting
#7
Mayako Uchida, Tsutomu Nakamura, Kojiro Hata, Hiroyuki Watanabe, Yasuo Mori, Koji Kato, Kenjiro Kamezaki, Katsuto Takenaka, Motoaki Shiratsuchi, Keiko Hosohata, Toshihiro Miyamoto, Koichi Akashi
Background: Antiemetic effects and safety of granisetron or palonosetron alone and in combination with a corticosteroid against chemotherapy-induced nausea and vomiting (CINV) were retrospectively evaluated in patients with Hodgkin lymphoma receiving adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) therapy. Methods: A total of 39 patients were eligible for this study. Before ABVD therapy, granisetron or palonosetron was intravenously administered with or without a corticosteroid (dexamethasone or hydrocortisone) and aprepitant...
2018: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29225909/improved-treatment-satisfaction-and-medication-adherence-after-readjusting-oral-medication-regimens-with-the-cooperation-of-health-insurance-pharmacy-in-type-2-diabetic-patients-in-japan
#8
Naoko Ogawa, Mitsuyoshi Takahara, Toshihiko Shiraiwa, Mayumi Yamamoto, Kaoru Yamamoto, Masayuki Doi, Yoko Yoshida, Setsuko Gotou
Background: Treatment satisfaction and medication adherence can be improved if physicians carefully monitor the situations, check the level of difficulties patients experience when taking medications at specific times, and readjust medication regimens based on this information. However, physicians in Japan encounter difficulties in taking enough time to collect this information in clinical practice. The aim of the current study was to investigate improvements in satisfaction and adherence with the cooperation of a health insurance pharmacy in clinical practice...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29177067/joint-symptoms-associated-with-anastrozole-and-letrozole-in-patients-with-breast-cancer-a-retrospective-comparative-study
#9
Yoshihito Morimoto, Shuhei Sarumaru, Yuko Oshima, Chiho Tsuruta, Kazuhiro Watanabe
Background: Joint symptoms are a common side effect of aromatase inhibitors. However, it is not known if the risk of these symptoms varies between the members of this drug class. The aim of this study was to compare the frequency of joint symptoms associated with anastrozole and that associated with letrozole. Methods: We retrospectively reviewed patients with breast cancer who were treated with anastrozole or letrozole at Tsukiji Breast Clinic, Japan, between April 2008 and July 2014...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29152321/impact-of-the-number-of-repeated-inhalations-and-patient-characteristics-on-the-residual-amount-of-inhaled-laninamivir-octanoate-hydrate-dry-powder-in-pediatric-patients-with-influenza
#10
Toshiki Murasaka, Kenji Ikemura, Tomoyuki Enokiya, Yuichi Muraki, Mayumi Ikemura, Koji Terada, Takuya Iwamoto, Masahiro Okuda
Background: A dry powder inhaled formulation is used for the anti-influenza drug laninamivir octanoate hydrate (laninamivir). Although two successive inhalations (puffs) are recommended to minimize residual amounts of active ingredients, previous reports suggest that pediatric patients with low peak inspiratory flow are unable to inhale the active ingredient adequately. In the present study, we prospectively investigated the appropriate number of repeated inhalations of laninamivir dry powder and factors influencing the residual amount of ingredients in pediatric patients with influenza...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28944076/association-between-itching-and-the-serum-zinc-levels-in-patients-with-varicose-veins
#11
Yasushi Takai, Keiichi Hiramoto, Yoshiyuki Nishimura, Ryota Uchida, Keigo Nishida, Kazuya Ooi
BACKGROUND: Varicose veins commonly occur in the lower extremities and can cause pain and discomfort in the affected area. Many patients with varicose veins suffer from itching, but its cause has not been sufficiently explained. In recent years, the role of zinc in maintaining the integrity of skin has been reported, and zinc supplementation has been suggested to be effective in relieving itching. The objective of this study is to elucidate the relationship between itching and serum zinc concentration in patients with varicose veins...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28944075/efficacy-of-switching-to-dolutegravir-plus-rilpivirine-the-small-tablet-regimen-in-patients-with-dysphagia-two-case-reports
#12
Takefumi Suzuki, Nobuko Hara, Morichika Osa, Kazuhisa Misawa, Kazuo Imai, Yuji Fujikura, Takuya Maeda, Wataru Sonehara, Akihiko Kawana
BACKGROUND: The advent of well-tolerated and effective anti-retroviral drugs against human immunodeficiency virus-1 (HIV-1) infection has been a major step forward that has achieved long-term survival in recent years. The number of HIV-1 infected patients who experience difficulty in swallowing tablets is expected to increase as the HIV-infected population advances in age or develops comorbidities or treatment sequelae affecting the central nervous system. CASE PRESENTATION: Here, we describe two HIV-1-infected patients who experienced progressive dysphagia leading to inability to swallow the antiretroviral tablets included in the standard regimen...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28808580/the-detection-of-influenza-virus-at-the-community-pharmacy-to-improve-the-management-of-local-residents-with-influenza-or-influenza-like-disease
#13
Akio Kawachi, Yusuke Sakamoto, Shunya Mouri, Mitsuaki Fukumori, Riku Kawano, Takaya Murakami, Junichiro Sonoda, Keiko Narumi, Yoshihiro Shimodozono, Kenji Etoh, Susumu Chiyotanda, Takashi Furuie, Keizo Sato, Masao Fukumori, Toshiro Motoya
BACKGROUND: As of 2014, community pharmacies in Japan are approved by the Ministry of Health, Labour and Welfare to measure lipid panel, HbA1c, glucose, ALT, AST and γ-GTP, but not to screen for influenza virus. We provided influenza virus screening tests at a community pharmacy to triage people with symptoms suggestive of influenza. Participants were given appropriate advice on how to prevent the spread of and safeguard against influenza. We subsequently evaluated the effects of community pharmacy-based influenza virus screening and prevention measures...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28770097/objective-evaluation-of-chemotherapy-induced-peripheral-neuropathy-using-quantitative-pain-measurement-system-pain-vision-%C3%A2-a-pilot-study
#14
Junya Sato, Megumi Mori, Satoru Nihei, Satoshi Takeuchi, Masahiro Kashiwaba, Kenzo Kudo
BACKGROUND: In an evaluation of chemotherapy-induced peripheral neuropathy (CIPN), objectivity may be poor because the evaluation is determined by the patient's subjective assessment. In such cases, management of neuropathy may be delayed and CIPN symptoms may become severe. In this pilot study, we attempted an objective evaluation of CIPN using a quantitative pain measurement system (Pain Vision(®)). METHODS: The subjects were patients with gynecologic cancer who underwent chemotherapy using taxane and platinum drugs...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28748102/kamishoyosan-and-shakuyakukanzoto-promote-recovery-from-paclitaxel-induced-neurite-retraction-in-pc12-cells
#15
Ken Konaka, Kota Moriyama, Takumi Sakurada, Naoto Okada, Masaki Imanishi, Yoshito Zamami, Kazuyoshi Kawazoe, Shuji Fushitani, Keisuke Ishizawa
BACKGROUND: In chemotherapy, the full round of treatment must be completed as scheduled to achieve the strongest therapeutic effect. However, peripheral neuropathy, a severe side effect of the chemotherapeutic agent paclitaxel, can force the premature discontinuation of treatment. As some kampo practitioners have suggested that it may be possible to counteract such side effects, we analyzed the effects of Kamishoyosan, Shakuyakukanzoto, and Goshajinkigan in an in vitro model of paclitaxel-induced peripheral neuropathy...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28729910/drug-induced-gingival-hyperplasia-a-retrospective-study-using-spontaneous-reporting-system-databases
#16
Haruna Hatahira, Junko Abe, Yuuki Hane, Toshinobu Matsui, Sayaka Sasaoka, Yumi Motooka, Shiori Hasegawa, Akiho Fukuda, Misa Naganuma, Tomofumi Ohmori, Yasutomi Kinosada, Mitsuhiro Nakamura
BACKGROUND: Drug-induced gingival hyperplasia (DIGH) causes problems with chewing, aesthetics, and pronunciation, and leads to the deterioration of the patient's quality of life (QOL). Thus, the aim of this study was to evaluate the incidence of DIGH using spontaneous reporting system (SRS) databases. METHODS: We analyzed reports of DIGH from SRS databases and calculated the reporting odds ratios (RORs) of suspected drugs (immunosuppressants, calcium channel blockers, and anticonvulsants)...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28702209/safety-of-human-papillomavirus-vaccines-in-healthy-young-women-a-meta-analysis-of-24-controlled-studies
#17
Yukari Ogawa, Hinako Takei, Ryuichi Ogawa, Kiyoshi Mihara
BACKGROUND: Human papillomavirus (HPV) vaccines have been shown to be effective for the eradication of HPV and prevention of cervical cancer. However, the number of women who receive HPV vaccinations has decreased over the last several years in Japan, due to concerns about adverse reactions associated with the vaccines. We evaluated the safety of three types of HPV vaccines separately in young women and the difference in the risk of adverse reactions between HPV and other vaccines by conducting a meta-analysis...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28652924/usefulness-of-limited-sampling-strategy-for-mycophenolic-acid-area-under-the-curve-considering-postoperative-days-in-living-donor-renal-transplant-recipients-with-concomitant-prolonged-release-tacrolimus
#18
Tomoyuki Enokiya, Kouhei Nishikawa, Yuichi Muraki, Takuya Iwamoto, Hideki Kanda, Yoshiki Sugimura, Masahiro Okuda
BACKGROUND: The optimal dose of mycophenolate mofetil (MMF) in renal transplant patients has been recommended to be decided on the basis of area under the concentration-time curve (AUC0-12) of mycophenolic acid (MPA). Although meta-analysis has revealed that postoperative day (POD) is an influencing factor in MPA pharmacokinetics, there are no reports regarding a limited sampling strategy (LSS) for MPA AUC in consideration of POD. The aim of this study was to construct of an LSS considering POD that appropriately expresses the MPA AUC following renal transplantation and evaluation of the usefulness...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28588901/development-and-evaluation-of-adsorption-sheet-hd-safe-sheet-u-using-active-carbon-for-the-purpose-of-the-preventing-the-contamination-diffusion-of-urinary-excreted-anticancer-drug
#19
Junya Sato, Haruka Ohkubo, Yuki Sasaki, Makoto Yokoi, Yasunori Hotta, Kenzo Kudo
BACKGROUND: Certain amount of anticancer drugs is excreted in the urine of patients receiving anticancer drugs, and urinary scattering including anticancer drugs at excretion has become a route of anticancer drug contamination. Therefore, we developed an active carbon sheet (HD safe sheet-U) that prevented diffusion by adsorbing anticancer drugs including that excreted in urine. The present study conducted a performance evaluation of this sheet. METHODS: The adsorption performance of active carbon to anticancer drug in the urine was evaluated by determining concentration changes in the active carbon suspension (5 mg/mL) of 14 kinds of anticancer drugs (cyclophosphamide, ifosfamide, carboplatin, cisplatin, methotrexate, 5-fluorouracil, cytarabine, gemcitabine, doxorubicin, epirubicin, paclitaxel, docetaxel, etoposide, and irinotecan) diluted with artificial urine...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28515955/effects-of-resistant-dextrin-for-weight-loss-in-overweight-adults-a-systematic-review-with-a-meta-analysis-of-randomized-controlled-trials
#20
Junichi Mukai, Yuta Tsuge, Michiko Yamada, Katsuya Otori, Koichiro Atsuda
BACKGROUND: Randomized controlled trials (RCTs) reported that resistant dextrin (RD) exerted pleiotropic effects on humans. However, limited information is available on the effects of RD for weight loss. We conducted a systematic review with a meta-analysis to summarize the available literature and compare the efficacy of RD for weight loss with that of a placebo in overweight adults. METHODS: We searched the electronic databases MEDLINE, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL, Web of Science, ClincalTrials...
2017: Journal of Pharmaceutical Health Care and Sciences
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