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B Proust, D Masson, B P Proust, M Baudron, F Dehaut
The novel HLA-B*41:50 allele differs from HLA-B*41:01:01 by a single nucleotide substitution at codon 116.
May 15, 2017: HLA
V Surendranath, V Albrecht, J D Hayhurst, B Schöne, J Robinson, S G E Marsh, A H Schmidt, V Lange
Recent years have seen a rapid increase in the discovery of novel allelic variants of the human leukocyte antigen (HLA) genes. Commonly, only the exons encoding the peptide binding domains of novel HLA alleles are submitted. As a result, the IPD-IMGT/HLA Database lacks sequence information outside those regions for the majority of known alleles. This has implications for the application of the new sequencing technologies, which deliver sequence data often covering the complete gene. As these technologies simplify the characterization of the complete gene regions, it is desirable for novel alleles to be submitted as full-length sequences to the database...
May 14, 2017: HLA
E Kuzmich, S Tyapushkina, A Alyanskiy, B Afanasyev
Two novel HLA class II alleles, HLA-DQB1*02:85 and HLA-DRB1*01:01:30, were detected in Russian individuals.
May 3, 2017: HLA
M Adamek, B Döhler, K K Hasan, G Fiedler, S Scherer, G Opelz, T H Tran
FoxP3 and Vav1 are known to be involved in the development of regulatory T cells. Two polymorphic sites in the FoxP3 promoter (rs3761548 and a (GT) n -dinucleotide repeat) and 2 single nucleotide polymorphisms in intron 1 of the Vav1 gene (rs2546133 and rs2617822) have been shown to correlate with gene expression levels. We investigated a potential impact of FoxP3 and Vav1 genetic variants on kidney allograft failure using samples and data of the Collaborative Transplant Study. A cohort of 384 kidney transplant patients was tested...
May 3, 2017: HLA
D Inotai, Z Illés, E Szabó, Á Varga, A Szilvási
The newly detected HLA-B*08:177 differs from HLA-B*08:01:01:01 by 1 single nucleotide substitution at position 365 of exon 3.
May 2, 2017: HLA
P Koefoed-Nielsen, I Weinreich, M Bengtsson, J Lauronen, C Naper, M Gäbel, S S Sørensen, L Wennberg, A V Reisaeter, B K Møller
BACKGROUND: Highly immunized patients are a challenge for organ transplantation programs. One way of increasing the likelihood of transplantation in this group of patients is to expand the possible donations by defining acceptable HLA mismatches. In the Scandiatransplant Acceptable Mismatch Program (STAMP), a de-centralized approach has been implemented in 2009. AIMS: The program has been improved during the years from utilizing HLA-A, -B, -DR matching only to include typing of all deceased donors for HLA-A, -B, -C, -DRB1 and -DQB1...
April 27, 2017: HLA
E Kuzmich, O Makarenko, A Alyanskiy, B Afanasyev
Sequence of the novel allele, HLA-B*44:02:45, differs from HLA-B*44:02:01:01 by 1-nucleotide exchange in exon 2.
April 23, 2017: HLA
J He, W Zhang, Z-D Han, W Wang, F-M Zhu
HLA-B*27:147 differs from HLA-B*27:04:01 by a single nucleotide substitution at position 523 C>G.
April 20, 2017: HLA
E Kuzmich, A Nasredinova, A Alyanskiy, B Afanasyev
Sequence of the novel allele, HLA-DQB1*06:210, differs from HLA-DQB1*06:03:01 by 1 nucleotide exchange in exon 2.
April 18, 2017: HLA
S Wenda, I Faé, G F Fischer
Antibody identification by a bead array assay in a kidney patient revealed several HLA-specific antibodies including one directed against the HLA-B7 antigen. Low-resolution typing of the patient indicated the presence of an HLA-B*07 allele. To rule out an HLA-specific autoantibody the HLA-typing of the patient was further refined by nucleotide sequencing on a next-generation sequencing platform and eventually showed an HLA-B*39:01:01:03 and HLA-B*07:181N genotype. Thereby the allospecific nature of the antibody was proven...
April 17, 2017: HLA
J W Zheng, J H Xie, Y Sun, Y Q Jiang, D Xiang
The HLA-B*40:242 allele differs from B*40:54 by 1 nucleotide substitution at position 190.
April 12, 2017: HLA
J-J He, Z-D Han, J He, J Xu, F-M Zhu
HLA-DRB1*15:127 has 1 nucleotide change from HLA-DRB1*15:01:01:01 at position 308 C>G.
April 9, 2017: HLA
M Battarra, R Condello, T Galluccio, C Stellitano, M Andreani
The novel allele HLA-A*03:275N differs from HLA-A*03:01:01:01 by 1 nucleotide substitutions in exon 2.
April 5, 2017: HLA
Y-P Xu, S-X Wang, S-Q Gao, H-B Zhang
KIR3DS1*083 allele differs from the closest allele KIR3DS1*01301 by 3 mutations in exon 4.
April 5, 2017: HLA
C L Chang, C Y Lin
A one nucleotide replacement in codon 261 of HLA-B*40:01:01 results in a novel allele, HLA-B*40:247.
April 5, 2017: HLA
W-X Li, G Li, L Yao, G Shen, R Yang, F-W Qiu, Y Ma
The novel allele HLA-A*02:505 was identified in a tuberculosis patient by human leukocyte antigen sequence-based typing.
April 5, 2017: HLA
C S M Kramer, D L Roelen, S Heidt, F H J Claas
Transplantation of an human leukocyte antigen (HLA) mismatched graft can lead to the development of donor-specific antibodies (DSA), which can result in antibody mediated rejection and graft loss as well as complicate repeat transplantation. These DSA are induced by foreign epitopes present on the mismatched HLA antigens of the donor. However, not all epitopes appear to be equally effective in their ability to induce DSA. Understanding the characteristics of HLA epitopes is crucial for optimal epitope matching in clinical transplantation...
April 5, 2017: HLA
A A Turganbekova, R I Ramilyeva, D K Baimukasheva, Zh K Burkitbayev, S A Abdrakhmanova
HLA-A*32:95 differs from A*32:01:01 at nucleotide 28 in exon 2 from C to A.
April 4, 2017: HLA
H Yu, X Ji, G J Ou, J Wang, Q Chen
HLA-B*39:119 allele differs from HLA-B*39:01:01:01 by a single nucleotide substitution at position 488.
April 3, 2017: HLA
Z Li, H-Y Zou
Full-length sequences of HLA-B*48:03:01 and B*48:04:01, confirmed by cloning and sequencing in Chinese donors.
April 2, 2017: HLA
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