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HLA

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https://www.readbyqxmd.com/read/30430763/identification-of-the-new-hla-drb5-01-01-01-02-allele-in-a-chinese-individual
#1
Riga Wu, Dan Peng, Nana Wang, Hongyu Sun, Jianjin Li
DRB5*01:01:01:02 differs from DRB5*01:01:01 by four nucleotide changes in intron 2. This article is protected by copyright. All rights reserved.
November 14, 2018: HLA
https://www.readbyqxmd.com/read/30421584/characterization-of-the-novel-hla-a-30-135-allele-by-sequencing-based-typing
#2
Marine Cargou, Mamy Ralazamahaleo, Laura Blouin, Gwendaline Guidicelli, Jonathan Visentin
HLA-A*30:135 differs from HLA-A*30:01:01 by one nucleotide substitution at codon 304 in exon 5. This article is protected by copyright. All rights reserved.
November 12, 2018: HLA
https://www.readbyqxmd.com/read/30421583/characterization-of-the-novel-hla-drb5-02-21-allele-by-sequencing-based-typing
#3
Marine Cargou, Mamy Ralazamahaleo, Laura Blouin, Gwendaline Guidicelli, Jonathan Visentin
HLA-DRB5*02:21 differs from HLA-DRB5*02:02:01 by one nucleotide substitution at codon 203 in exon 4. This article is protected by copyright. All rights reserved.
November 12, 2018: HLA
https://www.readbyqxmd.com/read/30421561/hla-b-45-22-a-novel-allele-that-differs-from-hla-b-45-01-01-at-several-locations
#4
Brian A Dukek, Micah D Zuccarelli, Laurie L Wakefield, Justin D Kreuter, Manish J Gandhi
Discovery of a novel HLA-B*45:22 allele in a Middle Eastern heart and lung transplant candidate. This article is protected by copyright. All rights reserved.
November 12, 2018: HLA
https://www.readbyqxmd.com/read/30421532/characterization-of-the-novel-hla-a-03-315-allele-by-sequencing-based-typing
#5
Marine Cargou, Vincent Elsermans, Isabelle Top, Gwendaline Guidicelli, Jonathan Visentin
HLA-A*03:315 differs from HLA-A*03:01:01:01 by one nucleotide substitution at codon 285 in exon 5. This article is protected by copyright. All rights reserved.
November 12, 2018: HLA
https://www.readbyqxmd.com/read/30421524/characterization-of-the-novel-hla-dpa1-02-12-allele-by-sequencing-based-typing
#6
Marine Cargou, Mamy Ralazamahaleo, Laura Blouin, Gwendaline Guidicelli, Jonathan Visentin
No abstract text is available yet for this article.
November 12, 2018: HLA
https://www.readbyqxmd.com/read/30421521/characterization-of-the-novel-hla-drb1-03-147-allele-by-sequencing-based-typing
#7
Mamy Ralazamahaleo, Vincent Elsermans, Isabelle Top, Gwendaline Guidicelli, Jonathan Visentin
HLA-DRB1*03:147 differs from HLA-DRB1*03:01:01:01 by one nucleotide substitution at codon 233 in exon 5. This article is protected by copyright. All rights reserved.
November 12, 2018: HLA
https://www.readbyqxmd.com/read/30387330/characterization-of-the-novel-hla-b-15-476-allele-by-sequencing-based-typing
#8
Mamy Ralazamahaleo, Vincent Elsermans, Isabelle Top, Gwendaline Guidicelli, Jonathan Visentin
HLA-B*15:476 differs from HLA-B*15:01:01:01 by one nucleotide substitution at codon 299 in exon 5. This article is protected by copyright. All rights reserved.
November 2, 2018: HLA
https://www.readbyqxmd.com/read/30387320/characterization-of-the-novel-hla-c-07-639-allele-by-sequencing-based-typing
#9
Marine Cargou, Mamy Ralazamahaleo, Laura Blouin, Gwendaline Guidicelli, Jonathan Visentin
No abstract text is available yet for this article.
November 2, 2018: HLA
https://www.readbyqxmd.com/read/30381896/a-novel-antibody-combination-to-identify-kir2ds2-high-nk-cells-in-kir2dl3-l2-s2-heterozygous-donors
#10
Matthew D Blunt, Pauline Rettman, Leidy Y Bastidas-Legarda, Rebecca Fulton, Valentina Capizzuto, Mohammed M Naiyer, James A Traherne, Salim I Khakoo
The killer cell immunoglobulin-like receptor (KIR) KIR2DS2 induces NK cell activation upon ligation and in genetic studies is associated with protection against certain cancers and viral infections. One of the difficulties in understanding KIR2DS2 has been that ligands have been hard to define. In part, this is because the high sequence homology between KIR2DS2 and KIR2DL3/KIR2DL2 has made it difficult to make antibodies that specifically detect NK cells expressing KIR2DS2. Using transfected NKL cells and primary human samples, we report the identification of a novel antibody combination which allows identification of NK cells with relatively high expression of KIR2DS2...
November 1, 2018: HLA
https://www.readbyqxmd.com/read/30381887/a-novel-hla-class-i-allele-hla-b-13-02-21-identified-by-sequence-based-typing-in-a-chinese-individual
#11
X-Y Gao, X-Y Chi, H Bin, Z-H Feng
HLA-B*13:02:21 was initially identified in a volunteer donor for China Marrow Donor Program. This article is protected by copyright. All rights reserved.
November 1, 2018: HLA
https://www.readbyqxmd.com/read/30378767/identification-of-a-novel-hla-dpb1-allele-hla-dpb1-612-01-in-a-chinese-individual
#12
W Xiong, D-M Wang, H-Y Zou
HLA-DPB1*612:01 differs from HLA-DPB1*13:01:01:01 by a single nucleotide substitution at codon 37 (CGC->TGC). This article is protected by copyright. All rights reserved.
October 31, 2018: HLA
https://www.readbyqxmd.com/read/30378746/characterization-of-the-novel-hla-dpb1-763-01-allele-by-sequencing-based-typing
#13
Marine Cargou, Vincent Elsermans, Isabelle Top, Gwendaline Guidicelli, Jonathan Visentin
HLA-DPB1*763:01 differs from HLA-DPB1*105:01:01:01 by one nucleotide substitution at codon 128 in exon 3. This article is protected by copyright. All rights reserved.
October 31, 2018: HLA
https://www.readbyqxmd.com/read/30362266/chimerism-as-an-important-marker-in-post-transplant-monitoring
#14
Hana Cechova, Monika Leontovycova, Lucie Pavlatova
Cell chimerism determination is important for the monitoring of engraftment dynamics and for relapse prediction. Our cohort of 474 patients was divided into two groups according to the determination methods used over time, and by their chimerism status. A significant difference in survival was observed between mixed vs. complete chimerism (p<0.0001 vs. p<0.0002) in both patient groups, and also vs. microchimerism (p=0.0201) in the second group. Detection of mixed chimerism is thus a high-risk factor, and microchimerism is potentially a risk factor in the post-transplantation course...
October 25, 2018: HLA
https://www.readbyqxmd.com/read/30311452/two-novel-alleles-hla-a-32-01-01-09-and-32-01-01-10-identified-by-pacific-bioscience-s-smrt-sequencing
#15
Charlotte A Cambridge, Thomas R Turner, Xenia Georgiou, Steven G E Marsh, Neema P Mayor
Pacific Bioscience's SMRT DNA sequencing was used to identify two novel intronic variants of HLA-A*32:01:01:01.
October 12, 2018: HLA
https://www.readbyqxmd.com/read/30311436/hla-dpb1-64-01n-and-dpb1-701-01-sequence-extensions-by-single-molecule-real-time-dna-sequencing
#16
Charlotte A Cambridge, Thomas R Turner, Jashan P Abraham, Steven G E Marsh, Neema P Mayor
Pacific Bioscience's SMRT sequencing was used to confirm and extend HLA-DPB1*64:01N and 701:01.
October 11, 2018: HLA
https://www.readbyqxmd.com/read/30270577/improved-flow-cytometry-crossmatching-in-kidney-transplantation
#17
REVIEW
Nicolas Guillaume
Flow cytometry crossmatching (FC-XM) assay is the most sensitive cell-based method for detecting donor-specific antibodies (DSAs). However, the use of FC-XM remains limited by methodological and clinical variations. This basic assay cannot discriminate between complement-fixing and non-complement-fixing antibodies. FC-XM also detects patient all antibodies bound to donor cells and not only DSAs against to human leukocyte antigen molecules. Pretest factors associated with a donor's medical care can affect test results by changing the number, viability and target on lymphocytes (such as rituximab on CD20+ B-cells)...
October 1, 2018: HLA
https://www.readbyqxmd.com/read/30270560/identification-of-trophoblast-specific-elements-in-the-hla-c-core-promoter
#18
Jenna K Johnson, Paul W Wright, Hongchuan Li, Stephen K Anderson
There are several aspects of HLA-C gene expression that distinguish it from the HLA-A and HLA-B genes. First, HLA-C is expressed by extravillous trophoblasts, whereas HLA-A and HLA-B are not. Second, its cell-surface expression is much lower, which has been linked to changes in transcription and efficiency of peptide loading and export. Third, HLA-C possesses a NK cell-specific promoter and a complex alternative splicing system that regulates expression during NK cell development. In this study, we investigate the contribution of the HLA-C core promoter to trophoblast-specific expression...
October 1, 2018: HLA
https://www.readbyqxmd.com/read/30270557/the-study-of-engraftment-after-hematopoietic-stem-cell-transplantation-from-the-presence-of-mixed-chimerism-to-the-development-of-immunological-tolerance
#19
Marco Andreani, Silvia Gregori
Over the last three decades, allogeneic haematopoietic stem cell transplantation (HSCT) has become an important therapeutic tool that can cure life-threatening diseases affecting children and adults, including a variety of neoplastic and inborn genetic disorders of the hematopoietic system. Engraftment of donor-derived cells represents a crucial event in order to obtain a successful transplant; therefore, many techniques have been developed to monitor engraftment and eventually determine the presence of mixed chimerism (MC) after HSCT...
October 1, 2018: HLA
https://www.readbyqxmd.com/read/30259709/hla-allele-and-haplotype-diversity-in-the-croatian-population-state-of-the-art
#20
Zorana Grubic
The aim of this report was to compare our data with data presented in the EFI catalogue (version 1.0) and to evaluate whether or not current (CUR) HLA alleles found in the Croatian population fall into the same categories of common (COM) or well-documented (WD) HLA alleles as those listed in the EFI catalogue. Among 237 HLA-A, -B, -DRB1 alleles observed in the Croatian population so far, 181 alleles were observed ≥3 times. According to our criteria, 36 alleles at HLA-A locus, 71 alleles at HLA-B locus and 51 alleles at HLA-DRB1 locus were characterised as CUR in Croatia (COM or WD in EFI catalogue), while 23 local HLA alleles are not listed at all among COM or WD alleles in EFI catalogue...
September 27, 2018: HLA
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