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C Campos-Silva, M K Kramer, M Valés-Gómez
NKG2D is a key receptor for the activation of immune effector cells, mainly Natural Killer cells and T lymphocytes, in infection, cancer and autoimmune diseases. Since the detection of ligands for NKG2D in sera of cancer patients is, in many human models, indicative of prognosis, a large number of studies have been undertaken to improve understanding of the biology regulating this receptor and its ligands, with the aim of translating this knowledge into clinical practice. Although it is becoming clear that the NKG2D system can be used as a tool for diagnosis and manipulated for therapy, some questions remain open due to the complexity associated with the existence of a large number of ligands, each one of them displaying distinct biological properties...
March 9, 2018: HLA
K L Yang, P Y Lin
One nucleotide replacement at codon 145 of HLA-B*15:01:01:01 results in a new allele, HLA-B*15:192.
March 9, 2018: HLA
J Pruszak, M Bernheiden, F Emmerich
HLA-B*50:01:09 differs by a synonymous nucleotide exchange in codon 17 from B*50:01:01.
March 9, 2018: HLA
L Liu, X-Y Chi, Y-L Zhu, S-X Jiao
The novel allele A*11:264 was identified in a Chinese individual by sequence-based typing.
March 5, 2018: HLA
G-Y Li, Y-Y Liu, K-L Wu, Zh-H Tang
HLA-B*27:103 has 1 nucleotide change from HLA-B*27:04:01 at position 121C>T.
March 2, 2018: HLA
C Xiaoyun, L Li, H Bin, J Shuxian
A novel allele A*31:126N was identified in a Chinese individual by sequence-based typing method.
March 1, 2018: HLA
Y L Zhou, Q Zhang
HLA-DQB1*03:23:03 has two nucleotide change from HLA-DQB1*03:03:02:01 at position 254 and 260.
February 26, 2018: HLA
J Strobel, B Hauck-Dlimi, K Dullinger, V Weisbach, J Zingsem
HLA-A*01:234 was identified by next generation sequencing and confirmed by Sanger sequencing.
February 22, 2018: HLA
L-N Dong, F Wang, W Zhang, J He, F-M Zhu
HLA-DQB1*06:209 has one nucleotide change from HLA-DQB1*06:01:01 at position 260 G>C in exon 2.
February 21, 2018: HLA
M Chowdhry, R N Makroo, Y Thakur, V Sharma, M Singh, M Kumar
The presence of donor specific antibodies directed against human leukocyte antigen significantly influences renal transplant due to antibody mediated rejection (AMR). We performed the screening of pre-renal transplant patients for preformed anti HLA antibodies using Antihuman globulin augmented-CDC crossmatch (AHG-CDCXm), Luminex donor specific crossmatch (LumXm) and HLA antibody screening. Seven hundred and fifty four patients were assessed for LumXm. HLA antibody screening was possible in 325 out of 754 cases...
February 19, 2018: HLA
M B Kamenaric, M Maskalan, J Drabbels, B G Cepulic, Z Grubic
The new allele HLA-B*18:37:02 differs from HLA-B*18:37:01 by one nucleotide substitutions in exon 2.
February 19, 2018: HLA
B G Park, S-K Kim, J Im, C E Yoon, H B Oh
Three novel HLA alleles, HLA-A*26:118, DQB1*02:65 and DPB1*05:01:07, were identified and confirmed by monoallelic sequencing.
February 16, 2018: HLA
M-R Huo, Y Yu, B Xi, D Li
HLA-A*33:138 differs from A*33:03:01 by a single nucleotide substitution at position 523 of exon 3.
February 14, 2018: HLA
B G Park, S-K Kim, J Im, C E Yoon, H B Oh
Four novel HLA alleles identified in Korean individuals, and confirmed by monoallelic sequencing.
February 12, 2018: HLA
S Fornaciari, R Sciarrino, C Biagini, M L Mariotti, M Curcio
A novel HLA-DPB1 allele, named HLA-DPB1*647:01, identified in a leukemia patient.
February 12, 2018: HLA
J Zingsem, B Hauck-Dlimi, K Dullinger, V Weisbach, J Strobel
HLA-C*01:136 identified by next generation sequencing and confirmed by Sanger sequencing.
February 8, 2018: HLA
S-X Zhao, Z-D Han, J He, J-T Chen, F-M Zhu
HLA-B*40:333 differs from HLA-B*40:01:01 by a single nucleotide substitution at position 380 T>C.
February 8, 2018: HLA
X Lafarge
We found a haplotype with the deletion of the HLA-DRB1 gene in two unrelated individuals originated from La Reunion Island, probably resulting from a deletion in the African haplotype A*30:02 ~ C*18:02 ~ B*57:03~DRB1*13:01.
February 5, 2018: HLA
B G Park, H-B Oh, J Im, C E Yoon, O-J Kwon
The new allele HLA-C*03:03:35 showed one nucleotide difference with C*03:03:01:01 at position 408 (G>T).
February 2, 2018: HLA
G Guidicelli, V Elsermans, I Top, M Ralazamahaleo, J Visentin
HLA-A*24:391 differs from HLA-A*24:02:01:01 by one nucleotide substitution at position 33.
February 2, 2018: HLA
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