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S Santos, J L Arroyo, C Eguizabal, A Balas, J L Vicario
Two novel HLA-C alleles, C*04:239 and C*05:137, were characterized in Spanish individuals.
October 26, 2016: HLA
F-M Zhu, W Zhang, N-Y Chen, L-N Dong, J He
HLA-A*33:97 has one base substitution at position 287 A>T in exon 2 compared to HLA-A*33:03:01.
October 26, 2016: HLA
S X Wang, Y P Xu
Genomic full-length sequences of HLA-A*24:08 and A*24:10, were identified by cloning and sequencing.
October 24, 2016: HLA
A H Mattsson, J V Kringelum, C Garde, M Nielsen
Pan-specific prediction of receptor-ligand interaction is conventionally done using machine-learning methods that integrates information about both receptor and ligand primary sequences. To achieve optimal performance using machine learning, dealing with overfitting and data redundancy is critical. Most often so-called ligand clustering methods have been used to deal with these issues in the context of pan-specific receptor-ligand predictions, and the MHC system the approach has proven highly effective for extrapolating information from a limited set of receptors with well characterized binding motifs, to others with no or very limited experimental characterization...
October 20, 2016: HLA
Y P Xu, B F Shan, S X Wang
Genomic full-length sequences of HLA-A*33:01:01 and A*33:03:01, were identified by cloning and sequencing.
October 20, 2016: HLA
R Sciarrino, M De Donno, C Biagini, G Rombolà, M Curcio
The HLA-B*18:122 allele showed four nucleotide differences from HLA-B*18:01:01:01.
October 20, 2016: HLA
R Chen, G-B Zhang, Z-H Deng
The novel KIR2DL4*00503 allele differs from the closest allele 2DL4*00501 by a single synonymous mutation.
October 16, 2016: HLA
H-Y Zou, S-Z Jin, D Zhou, D-M Wang
HLA-B*15:374 has one nucleotide change from HLA-B*15:02:01 at nucleotide 553 bp where G → A in exon 3.
October 13, 2016: HLA
M-R Huo, B Xi, Y Yu, D Li
HLA-DRB1*08:45:02 differs from DRB1*08:30:01 by a single nucleotide substitution at position 227 of exon 2.
October 11, 2016: HLA
C Fu, H Zhao, Y Wang, H Cai, Y Xiao, Y Zeng, H Chen
Glycosylation is one of the major posttranslational modifications of proteins. N-glycosylation (Asn-linked) and O-glycosylation (Ser/Thr-linked) are the two main forms. Abnormal O-glycosylation is frequently observed on the surface of tumor cells, and is associated with an adverse outcome and poor prognosis in patients with cancer. O-glycans (Tn, sTn, and T antigen) can be synthesized in the Golgi apparatus with the aid of several glycosyltransferases (such as T-synthase and ST6GalNAc-I) in a suitable environment...
September 28, 2016: HLA
C M Mariaselvam, C Fortier, D Charron, R Krishnamoorthy, R Tamouza, V S Negi
Rheumatoid arthritis (RA) is a complex multifactorial autoimmune disease characterized by inflammatory arthritis. The precise etiology and pathogenesis of RA remains elusive but evidence points towards stochastic interactions between genetic and environmental factors. This study investigated the distribution of human leucocyte antigen (HLA)-DRB1/DQB1 alleles in South Indian patients with rheumatoid arthritis (RA) and their influence on RA susceptibility and clinical phenotype. Low resolution HLA-DRB1 and -DQB1 typing was performed in 271 RA patients and 233 healthy controls by polymerase chain reaction (PCR) using sequence-specific primers (SSP)...
November 2016: HLA
(no author information available yet)
No abstract text is available yet for this article.
November 2016: HLA
M-Y Zhang, X-K Yang, H-F Pan, D-Q Ye
In order to determine whether tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene polymorphisms confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted to examine the association between TNFAIP3 polymorphisms and susceptibility to SLE. A systematic literature search was conducted to identify all relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the association...
November 2016: HLA
Z Grubic, M Maskalan, K Stingl Jankovic, S Zvecic, K Dumic Kubat, N Krnic, R Zunec, J Ille, V Kusec, M Dumic
The CYP21A2 mutations that are in linkage disequilibrium with particular HLA-A, -B, -DRB1 alleles/haplotypes, cause deficiency of the 21-hydroxylase enzyme (21-OHD) and account for the majority of congenital adrenal hyperplasia (CAH) cases. The aim of this study was to investigate those associations with the p.V282L mutation linked to the non-classical (NC) form of CAH among Croatians. The study included parents of patients with the NC form of CAH, positive for the p.V282L mutation (N = 55) and cadaveric donor samples (N = 231)...
November 2016: HLA
N Otting, M K H van der Wiel, G G M Doxiadis, R E Bontrop
Here we report 51 novel major histocompatibility complex (MHC) class II alleles in a group of related olive baboons.
November 2016: HLA
S Martin-Rodriguez, C Martinez-Carretero, A M Llorente-Lumbreras, M P Sanz-Izquierdo, I Bernardo-Gonzalez
HLA-B*50:01:08 differs from B*50:01:01 at nucleotides g.1206T>A (intron 3) and g.1658G>A (exon 4).
November 2016: HLA
B Proust, D Masson, B P Proust, M Baudron, F Dehaut
The novel HLA-B*08:163 allele differs from HLA-B*08:01:01:01 by a single nucleotide substitution at codon 105.
November 2016: HLA
H Yu, X Ji, Z Liu, J Wang, Q Chen
One nucleotide replacement in codon 41 of HLA-B*15:02:01 results in a novel allele, HLA-B*15:399.
November 2016: HLA
Y F Pei, H N Huang, H C Li, G G Wu
HLA-A*33:88 differs from HLA-A*33:03:01 by one nucleotide exchange at position 475, G>A (codon 135 GCG>ACG).
November 2016: HLA
B G Park, J Cho, J Im, O-J Kwon, H-S Kim
The HLA-A*26:01:01:03N allele shows a single nucleotide difference compared with HLA-A*26:01:01:01 in intron 4(1846 G>A).
November 2016: HLA
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