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E Enrich, L Mongay, J L Caro-Oleas, M J Herrero-Mata, F Rudilla
HLA-DQB1*02:102 differs from DQB1*02:01:01 by a single nucleotide substitution resulting in an amino acid change.
November 14, 2017: HLA
M Al Jumah, S Kojan, A M Al Shehri, M Al Balwi, I Al Abdulkarim, E M Masuadi, Y Alhaidan, A Alabdulrahman, H M Fakhoury, A H Hajeer
Several studies have investigated the association of different HLA antigens with multiple sclerosis (MS). However, only few studies have considered the association of high resolution HLA type and MS, with none yet from Saudi Arabia. The aim of this study was to investigate the association of HLA class II alleles with MS in the Saudi population. We used next generation sequencing to investigate HLA association with MS. This study was conducted at King Abdulaziz Medical City in Riyadh, Saudi Arabia. We found that several HLA-DRB1 and DQB1 alleles were associated with MS...
November 13, 2017: HLA
H Thude, S Rother, M Sterneck, J Klempnauer, B Nashan, R Schwinzer, M Koch
The KLRB1 gene encodes for CD161 expressed by different subsets of leukocytes involved in the development of acute liver transplant rejection. The single nucleotide polymorphism (SNP) 503T>C (rs1135816) in the KLRB1 gene represents a missense mutation modifying functional properties of CD161. The aim of our study is to determine whether the SNP 503T>C is associated with acute liver transplant rejection. We genotyped the SNP for 163 liver recipients without acute rejection, 125 recipients with a single acute rejection, and 53 recipients with multiple acute rejections...
November 7, 2017: HLA
J C Lee
Genetic studies in complex diseases have been highly successful, but have also been largely one-dimensional: predominantly focusing on the genetic contribution to disease susceptibility. While this is undoubtedly important - indeed it is a pre-requisite for understanding the mechanisms underlying disease development - there are many other important aspects of disease biology that have received comparatively little attention. In this review, I will discuss how existing genetic data can be leveraged to provide new insights into other aspects of disease biology, why such insights could change the way we think about complex disease, and how this could provide opportunities for better therapies and/or facilitate personalized medicine...
November 6, 2017: HLA
Lin Jinming, Zhang Yongbiao, Qinglin Peng, Hanbo Yang, Jingli Shi, Mingliang Gu, Wenming Zhao, Guochun Wang
Genetic variation in human leukocyte antigen (HLA) plays an important role in the pathogenesis of dermatomyositis (DM). The aim of this study was to investigate the association of HLA class II with DM in China. 224 DM patients and 300 healthy controls were randomly enrolled at China-Japan Friendship Hospital. High resolution typing of HLA-DRB1 alleles was performed by sequencing based typing (SBT). The HLA-DQA1 and HLA-DQB1 alleles were determined by PCR sequence-specific primers (SSP). The frequencies of HLA-DRB1*09:01 (28...
November 6, 2017: HLA
Xiao-Yang Zhou, Li-Qun Zhang, Yao Xiao, Xiao-Qin Yang, Jian-Ping Cai
HLA-DRB1*07:01:22 differs from HLA-DRB1*07:01:01:01 at position 244 (C > T) in exon 2.
October 27, 2017: HLA
María Rosa Moya-Quiles, Antonio Balas, Manuel Muro, Ana María García-Alonso, Jose L Vicario
Three new HLA class I alleles with synonymous mutations were identified.
October 24, 2017: HLA
Jiying Wang, Yan Zhang, Qinghua Li, Kun Ru, Xiaojing Wang
HLA-C*07:565 differs from HLA-C*07:02:01:01 (400C- > T, exon 3, L110F).
October 24, 2017: HLA
Bin Hu, Zhixia Yang, Haiping Pan, Shutao Pang
HLA-A*24:383 differs HLA-A*24:02:01:01 by one nucleotide substitution from C to G in exon 4, position 755.
October 24, 2017: HLA
F-Q Lin, X Zhang, B Zhang, C Wu, J-P Li
HLA-A*24:02:56 differs from A*24:02:01:01 by one nucleotide change at position 795 from C to T.
October 20, 2017: HLA
X Zhang, F-Q Lin, C Wu, B Zhang, J-P Li
HLA-A*02:01:72 has one synonymous nucleotide change from HLA-A*02:01:01:01 where 591 G is changed to A.
October 20, 2017: HLA
Haoqiang Ding, Yingfeng Huang, Yangkai Chen, Xin Ye
No abstract text is available yet for this article.
October 14, 2017: HLA
A Polvi, J Peräsaari, T Linjama, T Saarinen, S Koskela, Cem Voorter, T Jaatinen
New HLA alleles found in the Finnish population: A*03:283N, A*68:167, C*03:327 and C*03:361.
October 14, 2017: HLA
E Enrich, E Campos, J L Caro-Oleas, M J Herrero-Mata, F Rudilla
HLA-B*57:91 differs from HLA-B*57:01:01 by a single nucleotide substitution resulting in an amino acid change.
October 14, 2017: HLA
Y-P Zhong, Z-R Quan, H Chen, S-Q Gao
HLA-A*02:189 differs from HLA-A*02:01:01:01 by a single substitution in exon 3 (846 G>T).
October 10, 2017: HLA
W-H Ma, Y-Q Wu, Z-H Feng, S-T Pang
HLA-B*35:348 has 1 nucleotide substitution, c.817G > C (GTG→CTG at codon 248) compared with B*35:01:01:01.
October 10, 2017: HLA
K L Yang, P Y Lin
One nucleotide substitution at residue 526 of the HLA-C*14:15 results in a novel allele, HLA-C*14:87.
October 10, 2017: HLA
G J Ou, X Ji, J Wang, Z Liu
HLA-DRB1*09:30 shows a single nucleotide difference from DRB1*09:01:02 at nucleotide 250 (CGG→TGG).
October 5, 2017: HLA
Y Zhu, B Han, X Chi, B Hu, Z Feng
One nucleotide replacement at nucleotide 811 of HLA-A*02: 01:01:01 results in a new allele, HLA-A*02:692.
October 5, 2017: HLA
Z-H Feng, Z-X Yang, W-H Ma, S-T Pang
A total of 322 HLA-DRB1*04 alleles have been identified until July 2017(1). HLA-DRB1*04 is the most common HLA- DRB1 allele among North Chinese Han populations with the antigen frequency of 11.51% (2). The DRB1*04:05 , DRB1*04:06 and DRB1*04:01 alleles were well represented in Shandong Peninsula population with allele frequencies of 3.70%, 1.79% and 1.39% respectively (3).
October 5, 2017: HLA
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