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Z K Burkitbayev, S A Abdrakhmanova, A A Turganbekova, I R Ramilyeva, D K Baimukasheva
HLA-DQB1*03:82 differs from DQB1*03:01 at nucleotide 223 in exon 2 from G to A.
June 19, 2017: HLA
X Chai, H Zhang, X Yang, F Yang, N Liu
Four hundred novel human leukocyte antigen (HLA) alleles were identified in Chinese individuals: 100 HLA-A alleles, 100 HLA-B alleles, 101 HLA-C alleles, 28 HLA-DRB1 alleles and 71 HLA-DQB1 alleles. Comparing novel alleles with their most homologous allele, we found 72.73% non-synonymous nucleotide substitutions, 21.13% silent mutations, 3.90% nonsense mutations and 3.25% frameshift mutation. 352 (88%) of the 400 novel alleles are single nucleotide substitution variants when compared with their most homologous alleles and other novel alleles differ from their most similar allele by more than 1 nucleotide substitutions, such as 2, 3, 5, 6, 8 and so on...
June 16, 2017: HLA
L Toyo-Oka, S Mahasirimongkol, H Yanai, T Mushiroda, S Wattanapokayakit, N Wichukchinda, N Yamada, N Smittipat, T Juthayothin, P Palittapongarnpim, S Nedsuwan, P Kantipong, A Takahashi, M Kubo, P Sawanpanyalert, K Tokunaga
Tuberculosis (TB) occurs as a result of complex interactions between the host immune system and pathogen virulence factors. Human leukocyte antigen (HLA) class II molecules play an important role in the host immune system. However, no study has assessed the association between HLA class II genes and susceptibility to TB caused by specific strains. This study investigated the possible association of HLA class II genes with TB caused by modern and ancient Mycobacterium tuberculosis (MTB). The study included 682 patients with TB and 836 control subjects who were typed for HLA-DRB1 and HLA-DQB1 alleles...
June 14, 2017: HLA
F Sánchez-Gordo, J M Gomez-Zumaquero, J L Vicario, A Balas
The new B*50:51 allele was found in 3 Caucasians from Southern Spain.
June 12, 2017: HLA
S Ulrich, E Matzhold, U Posch, P Schlenke, W Helmberg
HLA-DRB3*02:61Q , a novel HLA-DRB3 allele identified in a volunteer bone marrow donor.
June 7, 2017: HLA
H J Yang, X D Mo, J B Fang, X Q Yang, T Zhang
One nucleotide substitution at position 497 of HLA-C*12:02:01 results in a novel allele, HLA-C*12:214.
June 6, 2017: HLA
S Alshiekh, L P Zhao, Å Lernmark, D E Geraghty, Å T Naluai, D Agardh
Celiac disease is associated with the HLA-DR3-DQA1*05:01-DQB1*02:01 and DR4-DQA1*03:01-DQB1*03:02 haplotypes. In addition, there are currently over 40 non-HLA loci associated with celiac disease. This study extends previous analyses on different HLA haplotypes in celiac disease using next generation targeted sequencing. Included were 143 patients with celiac disease and 135 non-celiac disease controls investigated at median 9.8 years (1.4-18.3 years). PCR-based amplification of HLA and sequencing with Illumina MiSeq technology were used for extended sequencing of the HLA class II haplotypes HLA-DRB1, DRB3, DRB4, DRB5, DQA1 and DQB1, respectively...
June 5, 2017: HLA
G Hönger, P Amico, M-L Arnold, B M Spriewald, S Schaub
It is unknown under what conditions and to what extent weak/non-complement (C)-binding IgG subclasses (IgG2/IgG4) can block C1q-binding triggered by C-binding IgG subclasses (IgG1/IgG3). Therefore, we investigated in vitro C1q-binding induced by IgG subclass mixtures targeting the same HLA epitope. Various mixtures of HLA class II specific monoclonal antibodies of different IgG subclasses but identical V-region were incubated with HLA DRB1*07:01 beads and monitored for C1q-binding. The lowest concentration to achieve maximum C1q-binding was measured for IgG3, followed by IgG1, while IgG2 and IgG4 did not show appreciable C1q-binding...
June 5, 2017: HLA
J Zhao, X-S Huang, S-M Peng, S-Y Mei, Y-P Xu
A novel HLA-G allele, HLA-G*01:01:01:07, was identified in a Chinese patient with Posner-Schlossman syndrome.
May 30, 2017: HLA
M-R Huo, B Xi, Y Yu, D Li
HLA-C*08:01:20 differs from C*08:01:01 by a single nucleotide substitution at position 93 of exon 2.
May 28, 2017: HLA
B Duygu, B M Matern, M Groeneweg, C E M Voorter, M G J Tilanus
HLA-A*02:683 is most similar to 4 different HLA-A*02 subtypes with a single nucleotide difference.
May 28, 2017: HLA
V Albrecht, C Zweiniger, V Surendranath, K Lang, G Schöfl, A Dahl, S Winkler, V Lange, I Böhme, A H Schmidt
The high-throughput department of DKMS Life Science Lab encounters novel human leukocyte antigen (HLA) alleles on a daily basis. To characterise these alleles, we have developed a system to sequence the whole gene from 5'- to 3'-UTR for the HLA loci A, B, C, DQB1 and DPB1 for submission to the European Molecular Biology Laboratory - European Nucleotide Archive (EMBL-ENA) and the IPD-IMGT/HLA Database. Our workflow is based on a dual redundant sequencing strategy. Using shotgun sequencing on an Illumina MiSeq instrument and single molecule real-time (SMRT) sequencing on a PacBio RS II instrument, we are able to achieve highly accurate HLA full-length consensus sequences...
May 25, 2017: HLA
K L Yang, P Y Lin
One nucleotide substitution at residue 74 of HLA-B*27:04:01 results in a novel allele, HLA-B*27:112.
May 24, 2017: HLA
K L Yang, P Y Lin
One nucleotide substitution at residue 227 of HLA-DRB1*15:02:01:01 results in a new allele, HLA-DRB1*15:11.
May 24, 2017: HLA
B Proust, D Masson, B P Proust, M Baudron, F Dehaut
The novel HLA-B*41:50 allele differs from HLA-B*41:01:01 by a single nucleotide substitution at codon 116.
May 15, 2017: HLA
E Kuzmich, S Tyapushkina, A Alyanskiy, B Afanasyev
Two novel HLA class II alleles, HLA-DQB1*02:85 and HLA-DRB1*01:01:30, were detected in Russian individuals.
May 3, 2017: HLA
M Adamek, B Döhler, K K Hasan, G Fiedler, S Scherer, G Opelz, T H Tran
FoxP3 and Vav1 are known to be involved in the development of regulatory T cells. Two polymorphic sites in the FoxP3 promoter (rs3761548 and a (GT) n -dinucleotide repeat) and 2 single nucleotide polymorphisms in intron 1 of the Vav1 gene (rs2546133 and rs2617822) have been shown to correlate with gene expression levels. We investigated a potential impact of FoxP3 and Vav1 genetic variants on kidney allograft failure using samples and data of the Collaborative Transplant Study. A cohort of 384 kidney transplant patients was tested...
May 3, 2017: HLA
D Inotai, Z Illés, E Szabó, Á Varga, A Szilvási
The newly detected HLA-B*08:177 differs from HLA-B*08:01:01:01 by 1 single nucleotide substitution at position 365 of exon 3.
May 2, 2017: HLA
E Kuzmich, O Makarenko, A Alyanskiy, B Afanasyev
Sequence of the novel allele, HLA-B*44:02:45, differs from HLA-B*44:02:01:01 by 1-nucleotide exchange in exon 2.
April 23, 2017: HLA
J He, W Zhang, Z-D Han, W Wang, F-M Zhu
HLA-B*27:147 differs from HLA-B*27:04:01 by a single nucleotide substitution at position 523 C>G.
April 20, 2017: HLA
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