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Bladder Cancer

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https://www.readbyqxmd.com/read/29152557/clinical-trials-corner
#1
Piyush K Agarwal, Cora N Sternberg
No abstract text is available yet for this article.
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/29152556/bladder-sparing-therapy-for-bcg-failures-i-intravesical-immunotherapy
#2
Edward M Messing
No abstract text is available yet for this article.
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/29152555/challenging-cases-in-urothelial-cancer
#3
Mark S Soloway
No abstract text is available yet for this article.
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/29152554/prevalence-of-clostridium-difficile-infection-in-patients-after-radical-cystectomy-and-neoadjuvant-chemotherapy
#4
Katherine J Cotter, Yunhua Fan, Gretchen K Sieger, Christopher J Weight, Badrinath R Konety
Background and Objectives: Clostridium Difficile is the most common cause of nosocomial infectious diarrhea. This study evaluates the prevalence and predictors of Clostridium Difficile infections in patients undergoing radical cystectomy with or without neoadjuvant chemotherapy. Methods: Retrospective chart review was performed of all patients undergoing cystectomy and urinary diversion at a single institution from 2011-2017. Infection was documented in all cases with testing for Clostridium Difficile polymerase chain reaction toxin B...
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/29152553/oncological-outcomes-of-sequential-intravesical-gemcitabine-and-docetaxel-in-patients-with-non-muscle-invasive-bladder-cancer
#5
Niv Milbar, Max Kates, Meera R Chappidi, Filippo Pederzoli, Takahiro Yoshida, Alexander Sankin, Phillip M Pierorazio, Mark P Schoenberg, Trinity J Bivalacqua
Background: Bacillus Calmette-Guérin (BCG) unresponsive/relapsing patients with non-muscle invasive bladder cancer (NMIBC) who prefer bladder preservation over radical cystectomy (RC) or those who do not qualify for surgery may be offered intravesical therapies. Gemcitabine (GEM) combined with Docetaxel (DOCE) has been offered at Johns Hopkins Hospital (JHH). Objective: To evaluate experience with GEM/DOCE, to confirm safety of the regimen, to identify populations that may benefit most, and to consider the appropriate endpoints for judging efficacy of second line therapies...
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/29152552/chemotherapy-versus-chemoradiation-for-node-positive-bladder-cancer-practice-patterns-and-outcomes-from-the-national-cancer-data-base
#6
Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
Background: Management of clinically node-positive bladder cancer (cN+ BC) is poorly defined; national guidelines recommend chemotherapy (CT) alone or chemoradiation (CRT). Objective: Using a large, contemporary dataset, we evaluated national practice patterns and outcomes of CT versus CRT to elucidate the optimal therapy for this patient population. Methods: The National Cancer Data Base (NCDB) was queried (2004-2013) for patients diagnosed with cTanyN1-3M0 BC...
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/29152551/bladder-cancer-recovery-pathways-a-systematic-review
#7
Ian Maloney, Daniel C Parker, Michael S Cookson, Sanjay Patel
Background: Enhanced recovery pathways, also known as fast-track protocols, have been adopted since the early 2000s by various surgical specialties with the goal of improving patient outcomes and reducing the cost burden of major surgery on the health care system. Objective: To review the scientific literature on the origin of enhanced recovery pathways, track the contemporary utilization of such practices for patients undergoing radical cystectomy, and analyze the available data regarding their effect on morbidity, mortality, and treatment cost...
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/29152550/tertiary-lymphoid-structures-associate-with-tumour-stage-in-urothelial-bladder-cancer
#8
Madhuri Koti, Amanda Shou Xu, Kevin Yi Mi Ren, Kash Visram, Runhan Ren, David M Berman, D Robert Siemens
Background: Urothelial bladder cancer (UBC) is a highly prevalent disease in North America, however its optimal management remains elusive. The contribution of B cell associated responses is poorly understood in bladder cancer. Lymphoid neogenesis is a hallmark of an active immune response at tumor sites that sometimes leads to formation of tertiary lymphoid structures (TLS) that resemble germinal centers formed in secondary lymphoid organs. Objective: This study was conducted with an aim to investigate the presence and characteristics of TLS in UBC with a focus to compare and contrast the TLS formation in treatment naive low grade non-muscle invasive (NMIBC) and muscle invasive bladder cancers (MIBC)...
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/29152549/systematic-review-and-meta-analysis-on-the-efficacy-of-chemotherapy-with-transurethral-resection-of-bladder-tumors-as-definitive-therapy-for-muscle-invasive-bladder-cancer
#9
George W Moran, Gen Li, Dennis J Robins, Justin T Matulay, James M McKiernan, Christopher B Anderson
Background: Bladder-sparing treatment of muscle invasive bladder cancer (MIBC) with systemic chemotherapy plus transurethral resection of bladder tumors (TURBT) is increasingly seen in the literature -both in case series and subanalyses of patients who opt out of or are unfit for radical cystectomy (RC). Survival outcomes among these patients are often impressive, but these are typically small retrospective studies from single institutions and therefore of limited clinical value. Objectives: Our aim is to summarize the literature regarding definitive treatment of MIBC with systemic chemotherapy plus TURBT and provide a meta-analysis of survival outcomes for patients who received this treatment...
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/29152548/quantitative-assessment-of-heterogeneity-in-bladder-tumor-mri-diffusivity-can-response-be-predicted-prior-to-neoadjuvant-chemotherapy
#10
Huyen T Nguyen, Amir Mortazavi, Kamal S Pohar, Debra L Zynger, Lai Wei, Zarine K Shah, Guang Jia, Michael V Knopp
Background: It is a critical unmet need to predict chemosensitivity in muscle-invasive bladder cancer patients who receive neoadjuvant chemotherapy (NAC). Quantification of tumor heterogeneity has been shown to be useful in the assessment of therapeutic response. Apparent diffusion coefficient (ADC) is derived from diffusion weighted MRI (DWI) to quantify the water diffusivity which characterizes micro-cellularity in tumor tissues. Objective: The aim of this study is to assess if a quantitative measurement of ADC heterogeneity in bladder tumors can be a predictor of therapeutic response to NAC...
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/29152547/evidence-of-atypical-recurrences-after-robot-assisted-radical-cystectomy-a-comprehensive-review-of-the-literature
#11
REVIEW
François Audenet, John P Sfakianos
Robot-assisted radical cystectomy (RARC) has seen remarkable growth in the last decade. Despite a low level of evidence, numerous publications reporting on outcomes after RARC are now available. While definitive data on the long-term oncologic safety and efficacy of this technique are still lacking, similar oncological and functional outcomes compared to open radical cystectomy (ORC) have been reported. Several studies have also reported on atypical recurrences after RARC, including peritoneal carcinomatosis, extra-pelvic lymph node metastasis and port-site metastasis...
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28824952/clinical-trials-corner
#12
Piyush K Agarwal, Cora N Sternberg
No abstract text is available yet for this article.
July 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28824951/the-bcg-shortage
#13
Edward M Messing
No abstract text is available yet for this article.
July 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28824950/challenging-cases-in-urothelial-cancer
#14
Mark S Soloway
No abstract text is available yet for this article.
July 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28824949/proceedings-of-the-3rd-annual-albert-institute-for-bladder-cancer-research-symposium
#15
Thomas W Flaig, Ashish M Kamat, Donna Hansel, Molly A Ingersoll, H Barton Grossman, Cathy Mendelsohn, David DeGraff, Joseph C Liao, John A Taylor
The Third Annual Albert Institute Bladder Symposium was held on September 8-10th, 2016, in Denver Colorado. Participants discussed several critical topics in the field of bladder cancer: 1) Best practices for tissue analysis and use to optimize correlative studies, 2) Modeling bladder cancer to facilitate understanding and innovation, 3) Targeted therapies for bladder cancer, 4) Tumor phylogeny in bladder cancer, 5) New Innovations in bladder cancer diagnostics. Our understanding of and approach to treating urothelial carcinoma is undergoing rapid advancement...
July 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28824948/the-antineoplastic-activity-of-photothermal-ablative-therapy-with-targeted-gold-nanorods-in-an-orthotopic-urinary-bladder-cancer-model
#16
Xiaoping Yang, Lih-Jen Su, Francisco G La Rosa, Elizabeth Erin Smith, Isabel R Schlaepfer, Suehyun K Cho, Brian Kavanagh, Wounjhang Park, Thomas W Flaig
BACKGROUND: Gold nanoparticles treated with near infrared (NIR) light can be heated preferentially, allowing for thermal ablation of targeted cells. The use of novel intravesical nanoparticle-directed therapy in conjunction with laser irradiation via a fiber optic cystoscope, represents a potential ablative treatment approach in patients with superficial bladder cancer. OBJECTIVE: To examine the thermal ablative effect of epidermal growth factor receptor (EGFR)-directed gold nanorods irradiated with NIR light in an orthotopic urinary bladder cancer model...
July 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28824947/high-dose-rate-intra-operative-radiation-therapy-during-high-risk-genitourinary-surgery-initial-observations-and-a-proposal-for-its-study-in-bladder-cancer
#17
Max Kates, Meera R Chappidi, Aaron Brant, Niv Milbar, Nikolai A Sopko, Christian Meyer, Stephanie A Terezakis, Joseph M Herman, Jonathan E Efron, Bashar Safar, Phuoc T Tran, Nita Ahuja, Phillip M Pierorazio, Trinity J Bivalacqua
BACKGROUND: High dose-rate Intra-Operative Radiation Therapy (HD-IORT) is used to provide effective local control for patients with high-risk locally advanced or recurrent tumors. However, the utility of HD-IORT for patients with bladder cancer has not been studied. OBJECTIVE: To characterize our institutional experience with HD-IORT in patients with cancer requiring genitourinary surgery, in an effort to identify patients with bladder cancer that may benefit from HD-IORT...
July 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28824946/use-of-adjuvant-chemotherapy-in-patients-with-advanced-bladder-cancer-after-neoadjuvant-chemotherapy
#18
Wilson Sui, Emerson A Lim, G Joel Decastro, James M McKiernan, Christopher B Anderson
OBJECTIVES: To compare the outcomes of adjuvant chemotherapy (AC) versus observation in patients with non-organ confined disease after neoadjuvant chemotherapy and radical cystectomy (RC). MATERIALS AND METHODS: Using the National Cancer Database, we identified patients who received NAC prior to RC and had advanced stage (pT3/4) or pathologically involved nodes (pN+) at the time of surgery from 2004-2013. We determined whether patients then received AC or were managed with observation only and used multivariable proportional hazards regression to estimate the impact of AC on overall survival...
July 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28824945/increased-proliferation-as-independent-predictor-of-disease-recurrence-in-initial-stage-pta-urothelial-bladder-cancer
#19
Johannes Breyer, Sanzhar Shalekenov, Atiqullah Aziz, Bastiaan W G van Rhijn, Johannes Bründl, Eva Lausenmeyer, Julius Schäfer, Stefan Denzinger, Christian Giedl, Maximilian Burger, Arndt Hartmann, Matthias Evert, Wolfgang Otto
OBJECTIVES: To investigate the predictive impact of the proliferation biomarker Ki-67 on the clinical course of patients with initial stage pTa urothelial carcinoma of the bladder (UCB). METHODS: We retrospectively analyzed all patients treated by transurethral resection of bladder tumors (TUR-B) for UCB between 1992-2004 in a single-center. Disease recurrence (≥pTa UCB) and absent tumor in histopathology, assessed by TUR-B with a non-malignant result for endoscopic suspect bladder lesion displayed endpoints...
July 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28824944/editorial-concerning-impact-of-the-level-of-urothelial-carcinoma-involvement-of-the-prostate-on-survival-after-radical-cystectomy
#20
EDITORIAL
Steven Shen, Seth P Lerner
No abstract text is available yet for this article.
July 27, 2017: Bladder Cancer
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