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Bladder Cancer

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https://www.readbyqxmd.com/read/30417057/clinical-trials-corner
#1
Piyush K Agarwal, Cora N Sternberg
No abstract text is available yet for this article.
October 29, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30417056/perioperative-blood-transfusions-and-bladder-cancer-outcomes
#2
Edward M Messing
No abstract text is available yet for this article.
October 29, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30417055/challenging-cases-in-urothelial-cancer
#3
Mark S Soloway
No abstract text is available yet for this article.
October 29, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30417054/immunology-immunotherapy-and-translating-basic-science-into-the-clinic-for-bladder-cancer
#4
Molly A Ingersoll, Xue Li, Brant A Inman, John W Greiner, Peter C Black, Rosalyn M Adam
The Fourth Annual Albert Institute Bladder Cancer Care and Research Symposium was held from September 14th-16th in Houston, Texas. The symposium covered a range of topics relevant to bladder cancer, including basic science aspects of immunology and immunotherapy that inform clinical management; intravesical therapy for non-muscle invasive disease; understanding the nuances of carcinoma in situ ; and optimizing patient care and outcomes following therapy. The moving landscape of bladder cancer from an industry perspective was also discussed...
October 29, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30417053/venous-thromboembolism-and-peri-operative-chemotherapy-for-muscle-invasive-bladder-cancer-a-population-based-study
#5
Kelly Brennan, Safiya Karim, R Christopher Doiron, D Robert Siemens, Christopher M Booth
Background: Chemotherapy and major pelvic surgery are established risk factors for venous thromboembolism (VTE). We evaluate the incidence rate, timing, and factors associated with VTE in patients with bladder cancer who underwent radical cystectomy and peri-operative chemotherapy in routine clinical practice. Methods: Electronic records of treatment were linked to the population-based Ontario Cancer Registry to identify all patients who underwent cystectomy for bladder cancer in Ontario 1994-2013...
October 29, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30417052/changes-in-lean-muscle-mass-associated-with-neoadjuvant-platinum-based-chemotherapy-in-patients-with-muscle-invasive-bladder-cancer
#6
Kalen J Rimar, Alexander P Glaser, Shilajit Kundu, Edward M Schaeffer, Joshua Meeks, Sarah P Psutka
Background: Baseline sarcopenia or severe lean muscle deficiency is independently associated with increased mortality after cystectomy for muscle-invasive urothelial carcinoma of the bladder (MIUC). The impact of chemotherapy on muscle mass in MIUC patients remains undefined. Objectives: To describe preoperative changes in body composition in MIUC patients receiving platinum-based neoadjuvant chemotherapy (NC). Methods: Patients with cT2-4 N0-1 M0 UC of the bladder who received NC were identified...
October 29, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30417051/increased-surgical-complications-in-smokers-undergoing-radical-cystectomy
#7
Niranjan J Sathianathen, Christopher J Weight, Stephanie L Jarosek, Badrinath R Konety
Background: Not only is smoking a risk factor for the development of bladder cancer, it has also been implicated in increasing surgical morbidity and mortality. In general, the demographic and clinical characteristics of smokers are different to non-smokers which can bias the results of the impact of smoking. Objective: To evaluate the impact of smoking on radical cystectomy outcomes. Methods: Radical cystectomy cases were identified in the National Surgical Quality Improvement Program database from 2007-2015...
October 29, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30417050/hyperthermic-intravesical-chemotherapy-for-bcg-unresponsive-non-muscle-invasive-bladder-cancer-patients
#8
Joep J de Jong, Kees Hendricksen, Marloes Rosier, Hugh Mostafid, Joost L Boormans
Background: Adjuvant intravesical instillations with bacillus Calmette-Guérin (BCG) is the recommended treatment option for patients with intermediate-and high-risk non-muscle invasive bladder cancer (NMIBC). Despite adequate BCG treatment, a large proportion of patients experience a recurrence. Although radical cystectomy is the gold standard for BCG unresponsive NMIBC, some patients are unfit or unwilling to consider this option. Objective: To assess the effectiveness of Hyperthermic IntraVEsical Chemotherapy (HIVEC® ) in BCG unresponsive NMIBC patients...
October 29, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30417049/evaluation-of-intraoperative-versus-postoperative-adjuvant-mitomycin-c-with-nephroureterectomy-for-urothelial-carcinoma-of-the-upper-urinary-tract
#9
Blake Noennig, Shahab Bozorgmehri, Russell Terry, Brandon Otto, Li-Ming Su, Paul L Crispen
Background: Results of randomized trials support a single dose of intravesical chemotherapy following radical nephroureterectomy (RNU) for urothelial carcinoma. Objective: To evaluate the impact of the timing of intravesical mitomycin C (MMC) administration on the rate of bladder tumor recurrence (BTR) following RNU. Methods: We performed a retrospective review of patients who underwent RNU for upper tract urothelial carcinoma (UTUC) and received intravesical MMC between 2008 and 2016...
October 29, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30417048/early-complications-and-mortality-following-radical-cystectomy-associations-with-malnutrition-and-obesity
#10
Karan Arora, Kristine T Hanson, Elizabeth B Habermann, Matthew K Tollefson, Sarah P Psutka
Background: There are conflicting data regarding the impact of obesity on postoperative outcomes following radical cystectomy (RC) and how obesity and malnutrition interact in patients undergoing RC. Objective: To evaluate associations of body mass index (BMI), significant preoperative weight loss, and hypoalbuminemia with 30-day complications and mortality after RC. Methods: Review of the American College of Surgeons National Surgical Quality Improvement Program database identified 2,055 patients who underwent RC (2006-12)...
October 29, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30417047/intravesical-radiofrequency-induced-chemohyperthermia-for-carcinoma-in-situ-of-the-urinary-bladder-a-retrospective-multicentre-study
#11
F Johannes P van Valenberg, Amir Kajtazovic, Giorgio Canepa, Gerson Lüdecke, Jill-Isabel Kilb, Katja K H Aben, Ofer Nativ, Sanjeev Madaan, Benjamin Ayres, Rami Issa, J Alfred Witjes
Objective: To examine the effect of intravesical radiofrequency-induced chemohyperthermia (RF-CHT) in carcinoma in-situ (CIS) patients overall and split according to previously received therapy. Methods: CIS patients that underwent an induction and maintenance phase of≥6 RF-CHT instillations, and had either pathology or cystoscopy plus cytology available at 6 months of follow-up were retrospectively included. Complete response (CR), recurrences, cystectomy-free rate, overall survival (OS), and adverse events were evaluated...
October 29, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30417046/urinary-biomarkers-in-the-evaluation-of-primary-hematuria-a-systematic-review-and-meta-analysis
#12
REVIEW
Niranjan J Sathianathen, Mohit Butaney, Christopher J Weight, Raj Kumar, Badrinath R Konety
Introduction: Urinary biomarkers are entering the clinical landscape as a non-invasive method to evaluate patients for bladder cancer, however it is currently predominantly used in the surveillance setting. The use of biomarkers in the setting of primary hematuria is not widespread despite initial promising results. This study comprehensively reviews the literature on the diagnostic performance of FDA-approved biomarkers in the evaluation of primary hematuria. Methods: According to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement, MEDLINE, EMBASE, ScienceDirect, Cochrane Libraries, HTA database, Google Scholar and Web of Science were searched up to June 2017 for studies assessing the diagnostic accuracy of FDA-approved urinary biomarkers amongst patients presenting with primary hematuria...
October 29, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112448/financial-toxicity-of-having-bladder-cancer
#13
Edward M Messing
No abstract text is available yet for this article.
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112447/clinical-trials-corner
#14
Piyush K Agarwal, Cora N Sternberg
No abstract text is available yet for this article.
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112446/challenging-cases-in-urothelial-cancer
#15
Mark S Soloway
No abstract text is available yet for this article.
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112445/new-horizons-in-bladder-cancer-research-report-of-the-15th-meeting-of-the-international-bladder-cancer-network-ibcn-in-lisbon-portugal-october-21-23-2017
#16
Peter C Black, Peter J Goebell, Ashish M Kamat, Roman Nawroth, Bernd J Schmitz-Dräger
No abstract text is available yet for this article.
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112444/low-frequency-of-intratumor-heterogeneity-in-bladder-cancer-tissue-microarrays
#17
Lovisa Jakobsson, Gunilla Chebil, Nour-Al-Dain Marzouka, Fredrik Liedberg, Gottfrid Sjödahl
Background: Intratumoral heterogeneity (ITH) is associated with clinical challenges such as possible differences in response to treatment and difficulties in classifying the tumor. Previously, ITH has been described in bladder cancer using detailed genetic analyses. However, in this disease, it is not known to what extent ITH actually occurs, or if it involves molecular subtyping, when assessment is achieved by immunohistochemistry (IHC) on the protein level using tissue microarrays (TMAs), the method most widely applied when analyzing large sample numbers...
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112443/systematic-review-depression-and-anxiety-prevalence-in-bladder-cancer-patients
#18
Liliana Vartolomei, Matteo Ferro, Vincenzo Mirone, Shahrokh F Shariat, Mihai Dorin Vartolomei
Background: Depression affects more than 300 million people of all ages worldwide. In patients with cancer the reported prevalence is up to 24%. Objective: To systematically review the literature to report the prevalence of depression and anxiety among patients with bladder cancer (BC). Methods: Web of Science, MEDLINE/PubMed, and The Cochrane Library were searched between January and March 2018 using the terms "bladder carcinoma OR bladder cancer AND depression OR anxiety"...
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112442/radiation-therapy-as-definitive-local-treatment-in-patients-with-limited-stage-small-cell-carcinoma-of-the-bladder-does-total-dose-matter
#19
Elizabeth Germino, Benjamin W Fischer-Valuck, Soumon Rudra, Yuan James Rao, Jessika Contreras, Christopher Abraham, Jeff Michalski, Hiram Gay
Purpose: To determine whether total radiation dose affects survival outcomes for patients with small cell carcinoma of the bladder (SCCB). Methods: We queried the National Cancer Database (NCDB) for patients with limited stage SCCB undergoing multimodality treatment and retrospectively analyzed survival outcomes according to total radiation dose received. Results: Patients aged 41-79 receiving a total radiation dose of 54 Gy or greater had a significant improvement in overall survival compared to those receiving less than 54 Gy, with a median overall survival of 58...
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112441/total-fluid-intake-and-the-risk-of-recurrence-in-patients-with-non-muscle-invasive-bladder-cancer-a-prospective-cohort-study
#20
Sylvia H J Jochems, Frits H M van Osch, Raoul C Reulen, Mitch van Hensbergen, Duncan Nekeman, Sarah J Pirrie, Anke Wesselius, Frederik J van Schooten, Nicholas D James, D Michael A Wallace, Richard T Bryan, K K Cheng, Maurice P Zeegers
Objectives: To investigate the role of fluid intake from beverages before and after a diagnosis of bladder cancer in relation to the risk of developing bladder cancer recurrence. Study Design: Prospective cohort study. Methods: 716 patients with non-muscle invasive bladder cancer (NMIBC), who received transurethral resection of a primary bladder tumour (TURBT) and completed self-administrated questionnaires on usual fluid intake from beverages at time of diagnosis (over the year before diagnosis) and during follow-up (over the year after diagnosis), were included...
July 30, 2018: Bladder Cancer
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