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Bladder Cancer

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https://www.readbyqxmd.com/read/30112448/financial-toxicity-of-having-bladder-cancer
#1
Edward M Messing
No abstract text is available yet for this article.
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112447/clinical-trials-corner
#2
Piyush K Agarwal, Cora N Sternberg
No abstract text is available yet for this article.
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112446/challenging-cases-in-urothelial-cancer
#3
Mark S Soloway
No abstract text is available yet for this article.
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112445/new-horizons-in-bladder-cancer-research-report-of-the-15th-meeting-of-the-international-bladder-cancer-network-ibcn-in-lisbon-portugal-october-21-23-2017
#4
Peter C Black, Peter J Goebell, Ashish M Kamat, Roman Nawroth, Bernd J Schmitz-Dräger
No abstract text is available yet for this article.
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112444/low-frequency-of-intratumor-heterogeneity-in-bladder-cancer-tissue-microarrays
#5
Lovisa Jakobsson, Gunilla Chebil, Nour-Al-Dain Marzouka, Fredrik Liedberg, Gottfrid Sjödahl
Background: Intratumoral heterogeneity (ITH) is associated with clinical challenges such as possible differences in response to treatment and difficulties in classifying the tumor. Previously, ITH has been described in bladder cancer using detailed genetic analyses. However, in this disease, it is not known to what extent ITH actually occurs, or if it involves molecular subtyping, when assessment is achieved by immunohistochemistry (IHC) on the protein level using tissue microarrays (TMAs), the method most widely applied when analyzing large sample numbers...
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112443/systematic-review-depression-and-anxiety-prevalence-in-bladder-cancer-patients
#6
Liliana Vartolomei, Matteo Ferro, Vincenzo Mirone, Shahrokh F Shariat, Mihai Dorin Vartolomei
Background: Depression affects more than 300 million people of all ages worldwide. In patients with cancer the reported prevalence is up to 24%. Objective: To systematically review the literature to report the prevalence of depression and anxiety among patients with bladder cancer (BC). Methods: Web of Science, MEDLINE/PubMed, and The Cochrane Library were searched between January and March 2018 using the terms "bladder carcinoma OR bladder cancer AND depression OR anxiety"...
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112442/radiation-therapy-as-definitive-local-treatment-in-patients-with-limited-stage-small-cell-carcinoma-of-the-bladder-does-total-dose-matter
#7
Elizabeth Germino, Benjamin W Fischer-Valuck, Soumon Rudra, Yuan James Rao, Jessika Contreras, Christopher Abraham, Jeff Michalski, Hiram Gay
Purpose: To determine whether total radiation dose affects survival outcomes for patients with small cell carcinoma of the bladder (SCCB). Methods: We queried the National Cancer Database (NCDB) for patients with limited stage SCCB undergoing multimodality treatment and retrospectively analyzed survival outcomes according to total radiation dose received. Results: Patients aged 41-79 receiving a total radiation dose of 54 Gy or greater had a significant improvement in overall survival compared to those receiving less than 54 Gy, with a median overall survival of 58...
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112441/total-fluid-intake-and-the-risk-of-recurrence-in-patients-with-non-muscle-invasive-bladder-cancer-a-prospective-cohort-study
#8
Sylvia H J Jochems, Frits H M van Osch, Raoul C Reulen, Mitch van Hensbergen, Duncan Nekeman, Sarah J Pirrie, Anke Wesselius, Frederik J van Schooten, Nicholas D James, D Michael A Wallace, Richard T Bryan, K K Cheng, Maurice P Zeegers
Objectives: To investigate the role of fluid intake from beverages before and after a diagnosis of bladder cancer in relation to the risk of developing bladder cancer recurrence. Study Design: Prospective cohort study. Methods: 716 patients with non-muscle invasive bladder cancer (NMIBC), who received transurethral resection of a primary bladder tumour (TURBT) and completed self-administrated questionnaires on usual fluid intake from beverages at time of diagnosis (over the year before diagnosis) and during follow-up (over the year after diagnosis), were included...
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112440/double-blind-randomized-placebo-controlled-studies-evaluating-apaziquone-e09-qapzola%C3%A2-intravesical-instillation-post-transurethral-resection-of-bladder-tumors-for-the-treatment-of-low-risk-non-muscle-invasive-bladder-cancer
#9
Lawrence Karsh, Neal Shore, Mark Soloway, Gajanan Bhat, Guru Reddy, Szu-Yun Leu, J Alfred Witjes
Background: Guidelines recommend a single postoperative instillation of intravesical chemotherapy within 24 hours of transurethral resection of bladder tumors (TURBT) in patients with low- and intermediate-risk non-muscle invasive bladder cancer (NMIBC) to reduce recurrence risk. Objective: To evaluate the 2-year recurrence rate (2-YRR) of bladder cancer in randomized patients with Ta, G1-G2 histology who receive TURBT plus apaziquone versus TURBT plus placebo. Methods: Two nearly identical Phase 3, multinational, randomized, double-blind, placebo-controlled trials were conducted in patients with histologically confirmed Ta, G1-G2 NMIBC (Target Population) to evaluate the efficacy/safety of a single instillation of apaziquone post-TURBT...
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112439/fatty-acid-patterns-detected-by-ambient-ionization-mass-spectrometry-in-canine-invasive-urothelial-carcinoma-from-dogs-of-different-breeds
#10
Cedric A D'Hue, Deepika Dhawan, Tyler Peat, José Ramos-Vara, Alan Jarmusch, Deborah W Knapp, R Graham Cooks
Background: In early work ambient ionization mass spectrometry (MS) revealed lipid patterns distinguishing muscle invasive bladder cancer (invasive urothelial carcinoma, InvUC) from normal urothelium. A new ambient ionization MS approach, touch spray MS (TS-MS) can rapidly generate mass spectra in real time, potentially in a point-of-care setting. A tissue sample removed from a patient is touched by a probe, and mass spectra generated within seconds. Objective: To validate TS-MS methods using specimens from naturally-occurring InvUC in dogs where the cancer closely mimics the human condition, and to demonstrate proof-of-concept that TS-MS can elucidate lipid patterns distinguishing InvUC from normal urothelium...
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112438/a-gene-expression-signature-predicts-bladder-cancer-cell-line-sensitivity-to-egfr-inhibition
#11
Andrew Goodspeed, Annie Jean, Dan Theodorescu, James C Costello
Background: Bladder cancer remains a cancer type in need of novel and alternative therapies. While multiple inhibitors of EGFR have been evaluated for efficacy in bladder cancer, the results have largely been disappointing with few patients responding to these therapies. Yet, there is a subset of patients that positively responds to EGFR inhibition with tumor shrinkage, indicating it is an effective treatment for a targeted set of bladder tumors. Objective: To derive a gene expression signature capable of predicting the response to EGFR inhibition in bladder cancer cell lines...
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112437/systematic-review-an-update-on-the-spectrum-of-urological-malignancies-in-lynch-syndrome
#12
Dora Huang, Surena F Matin, Nathan Lawrentschuk, Morgan Roupret
Background: Lynch syndrome is an autosomal dominant disorder that predisposes individuals affected to certain malignancies. Colon and endometrial cancers are the malignancies most highly associated with Lynch syndrome. However, growing body of evidence links Lynch syndrome to urological cancers. Objective: This review aims to clarify the type of urological malignancies that fall under the Lynch-associated cancer spectrum. Methods: Using PRISMA guidelines, a systematic search between January 1990 to February 2018, was conducted using the MEDLINE database with the application of the following MESH terms: colorectal neoplasms, hereditary nonpolyposis; DNA mismatch repair; urologic neoplasms; kidney pelvis; ureteral neoplasms; urinary bladder; carcinoma, transitional cell; prostatic neoplasms; testicular neoplasms...
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30112436/antibody-drug-conjugates-in-bladder-cancer
#13
REVIEW
Panagiotis J Vlachostergios, Christopher D Jakubowski, Muhammad J Niaz, Aileen Lee, Charlene Thomas, Amy L Hackett, Priyanka Patel, Naureen Rashid, Scott T Tagawa
Urothelial carcinoma (UC) is characterized by expression of a plethora of cell surface antigens, thus offering opportunities for specific therapeutic targeting with use of antibody-drug conjugates (ADCs). ADCs are structured from two major constituents, a monoclonal antibody (mAb) against a specific target and a cytotoxic drug connected via a linker molecule. Several ADCs are developed against different UC surface markers, but the ones at most advanced stages of development include sacituzumab govitecan (IMMU-132), enfortumab vedotin (ASG-22CE/ASG-22ME), ASG-15ME for advanced UC, and oportuzumab monatox (VB4-845) for early UC...
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29951574/clinical-trials-corner
#14
Piyush K Agarwal, Cora N Sternberg
No abstract text is available yet for this article.
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29732395/psychological-stress-and-suicide-in-bladder-cancer-patients
#15
Edward M Messing
No abstract text is available yet for this article.
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29732394/challenging-cases-in-urothelial-cancer
#16
Mark S Soloway
No abstract text is available yet for this article.
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29732393/real-world-effectiveness-of-chemotherapy-in-elderly-patients-with-metastatic-bladder-cancer-in-the-united-states
#17
Matthew D Galsky, Sumanta Kumar Pal, Shih-Wen Lin, Sarika Ogale, Marko Zivkovic, Joseph Simpson, Christina Derleth, Christina Schiff, Guru Sonpavde
Background: Outcomes for patients with metastatic bladder cancer (mBC) are generally poor and progressively worse following first-line (1L) chemotherapy. Objective: To evaluate treatment patterns, survival outcomes, and characteristics of a large, real-world US population of elderly patients with advanced mBC receiving 1L and second-line (2L) treatment retrospectively. Methods: We identified patients with advanced mBC (aged ≥66 years)-newly diagnosed between January 1, 2004, and December 31, 2011-in the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) Program-Medicare linked database and assessed their palliative systemic chemotherapy treatments and survival outcomes...
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29732392/bladder-cancer-genetic-susceptibility-a-systematic-review
#18
Evangelina López de Maturana, Marta Rava, Chiaka Anumudu, Olga Sáez, Dolores Alonso, Núria Malats
Background: The variant/gene candidate approach to explore bladder cancer (BC) genetic susceptibility has been applied in many studies with significant findings reported. However, results are not always conclusive due to the lack of replication by subsequent studies. Objectives: To identify all epidemiological investigations on the genetic associations with BC risk, to quantify the likely magnitude of the associations by applying metaanalysis methodology and to assess whether there is a potential for publication/reporting bias...
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29732391/the-role-of-adjuvant-radiation-therapy-in-locally-advanced-bladder-cancer
#19
Gary D Lewis, Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
Background: The standard of care for locally advanced bladder cancer (LABC) is neoadjuvant chemotherapy followed by cystectomy. However, the role of adjuvant therapy for locally advanced bladder cancer is unclear. Objective: The purpose of this study was to evaluate the outcomes of adjuvant radiation therapy (RT) for patients with LABC, and to determine which risk factors best predict for patients who may best benefit from adjuvant RT. Methods: The National Cancer Data Base (NCDB) was queried (2004- 2013) for patients with newly-diagnosed pT3-4N0-3M0 urothelial carcinoma of the bladder that received neoadjuvant chemotherapy and cystectomy...
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29732390/prognostication-in-patients-treated-with-radical-cystectomy-for-urothelial-bladder-carcinoma-a-new-simplified-model-incorporating-histological-variants
#20
Ja Hyeon Ku, Hyeong Dong Yuk, Guiherme Godoy, Gilard E Amiel, Seth P Lerner
Purpose: The aim of this study was to evaluate the clinical significance of histological variants (HV) and to develop a new and simple prediction model incorporating variant forms in patients who underwent radical cystectomy for urothelial carcinoma (UC). Materials and methods: We analyzed the data of 365 patients. We evaluated whether HV were independent predictors of survival. A new scoring model was developed using the regression coefficients from the multivariate Cox proportional hazard model...
April 26, 2018: Bladder Cancer
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