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Antioxidants (Basel, Switzerland)

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https://www.readbyqxmd.com/read/29039798/the-effect-of-taurine-on-the-recovery-from-eccentric-exercise-induced-muscle-damage-in-males
#1
Yanita McLeay, Stephen Stannard, Matthew Barnes
Eccentric exercise is known to bring about microstructural damage to muscle, initiating an inflammatory cascade involving various reactive oxygen species. This, in turn, can significantly impair physical performance over subsequent days. Taurine, a powerful endogenous antioxidant, has previously been shown to have a beneficial effect on muscle damage markers and recovery when taken for a few days to several weeks prior to eccentric exercise. However, to date no studies have looked at the effects of supplementing over the days following eccentric exercise on performance recovery...
October 17, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29036891/total-phenolic-and-yellow-pigment-contents-and-antioxidant-activities-of-durum-wheat-milling-fractions
#2
Bin Xiao Fu, Constance Chiremba, Curtis J Pozniak, Kun Wang, Shin Nam
The aim of this study was to investigate the distribution of total yellow pigments, total phenolic compounds, and their antioxidant activities in various durum wheat milling fractions. Carotenoid composition of yellow pigment extract was also examined using UPLC. The ABTS radical scavenging activity of the milling fractions decreased in the order of short bran/bran > feed flour > flour/semolina in both total phenolic and total yellow pigment extracts. Yellow pigments extracts from bran, short bran, and feed flour exhibited 5...
October 14, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29027929/procyanidin-b2-protects-neurons-from-oxidative-nitrosative-and-excitotoxic-stress
#3
Taylor C Sutcliffe, Aimee N Winter, Noelle C Punessen, Daniel A Linseman
The aberrant generation of oxygen and nitrogen free radicals can cause severe damage to key cellular components, resulting in cell apoptosis. Similarly, excitotoxicity leads to protease activation and mitochondrial dysfunction, which subsequently causes cell death. Each of these factors play critical roles in the neuronal cell death underlying various neurodegenerative diseases. Procyanidin B2 (PB2) is a naturally occurring polyphenolic compound found in high concentrations in cocoa, apples, and grapes. Here, we examine the neuroprotective effects of PB2 in primary cultures of rat cerebellar granule neurons (CGNs) exposed to various stressors...
October 13, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28973985/s-adenosylmethionine-and-superoxide-dismutase-1-synergistically-counteract-alzheimer-s-disease-features-progression-in-tgcrnd8-mice
#4
Rosaria A Cavallaro, Vincenzina Nicolia, Maria Teresa Fiorenza, Sigfrido Scarpa, Andrea Fuso
Recent evidence emphasizes the role of dysregulated one-carbon metabolism in Alzheimer's Disease (AD). Exploiting a nutritional B-vitamin deficiency paradigm, we have previously shown that PSEN1 and BACE1 activity is modulated by one-carbon metabolism, leading to increased amyloid production. We have also demonstrated that S-adenosylmethionine (SAM) supplementation contrasted the AD-like features, induced by B-vitamin deficiency. In the present study, we expanded these observations by investigating the effects of SAM and SOD (Superoxide dismutase) association...
September 30, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28956814/chemotherapy-induced-tissue-injury-an-insight-into-the-role-of-extracellular-vesicles-mediated-oxidative-stress-responses
#5
REVIEW
Chontida Yarana, Daret K St Clair
The short- and long-term side effects of chemotherapy limit the maximum therapeutic dose and impair quality of life of survivors. Injury to normal tissues, especially chemotherapy-induced cardiomyopathy, is an unintended outcome that presents devastating health impacts. Approximately half of the drugs approved by the Food and Drug Administration for cancer treatment are associated with the generation of reactive oxygen species, and Doxorubicin (Dox) is one of them. Dox undergoes redox cycling by involving its quinone structure in the production of superoxide free radicals, which are thought to be instrumental to the role it plays in cardiomyopathy...
September 28, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28954417/modulation-of-nrf2-by-olive-oil-and-wine-polyphenols-and-neuroprotection
#6
REVIEW
Miriam Martínez-Huélamo, Jose Rodríguez-Morató, Anna Boronat, Rafael de la Torre
Strong adherence to a Mediterranean diet is associated with improved cognitive function and a lower prevalence of mild cognitive impairment. Olive oil and red wine are rich sources of polyphenols which are responsible in part for the beneficial effects on cognitive functioning. Polyphenols induce endogenous antioxidant defense mechanisms by modulating transcription factors such as the nuclear factor (erythroid-derived 2)-like 2 (Nrf2). This review discusses the scientific data supporting the modulating effect of olive oil and red wine polyphenols on Nrf2 expression, and the potential health benefits associated with cognitive functioning...
September 26, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28954414/alpha-lipoic-acid-downregulates-il-1%C3%AE-and-il-6-by-dna-hypermethylation-in-sk-n-be-neuroblastoma-cells
#7
Simona Dinicola, Sara Proietti, Alessandra Cucina, Mariano Bizzarri, Andrea Fuso
Alpha-lipoic acid (ALA) is a pleiotropic molecule with antioxidant and anti-inflammatory properties, of which the effects are exerted through the modulation of NF-kB. This nuclear factor, in fact, modulates different inflammatory cytokines, including IL-1b and IL-6, in different tissues and cell types. We recently showed that IL-1b and IL-6 DNA methylation is modulated in the brain of Alzheimer's disease patients, and that IL-1b expression is associated to DNA methylation in the brain of patients with tuberous sclerosis complex...
September 26, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930147/profiling-of-polyphenol-composition-and-antiradical-capacity-of-erica-cinerea
#8
Alfredo Aires, Rosa Carvalho
The aim of the current study was to determine the profile and content of polyphenols present in Erica cinerea, an important plant species from Northern Portuguese flora and often reported as having anti-inflammatory, antioxidant, and anti-radical activity. The analysis of polyphenols was performed by HPLC-DAD/UV-Vis, and the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+) method was used to evaluate its radical scavenging activity. HPLC analysis showed that both plants presented a great diversity of compounds, with 33% flavones, 28% flavanols, and 26% hydroxycinnamic acids...
September 20, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28914789/phytochemical-constituents-health-benefits-and-industrial-applications-of-grape-seeds-a-mini-review
#9
REVIEW
Zheng Feei Ma, Hongxia Zhang
Grapes are one of the most widely grown fruits and have been used for winemaking since the ancient Greek and Roman civilizations. Grape seeds are rich in proanthocyanidins which have been shown to possess potent free radical scavenging activity. Grape seeds are a complex matrix containing 40% fiber, 16% oil, 11% proteins, and 7% complex phenols such as tannins. Grape seeds are rich sources of flavonoids and contain monomers, dimers, trimers, oligomers, and polymers. The monomeric compounds includes (+)-catechins, (-)-epicatechin, and (-)-epicatechin-3-O-gallate...
September 15, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28914764/antioxidant-activity-of-spices-and-their-impact-on-human-health-a-review
#10
REVIEW
Alexander Yashin, Yakov Yashin, Xiaoyan Xia, Boris Nemzer
Antioxidants are substances that prevent oxidation of other compounds or neutralize free radicals. Spices and herbs are rich sources of antioxidants. They have been used in food and beverages to enhance flavor, aroma and color. Due to their excellent antioxidant activity, spices and herbs have also been used to treat some diseases. In this review article, the chemical composition and antioxidant activity of spices and culinary herbs are presented. The content of flavonoids and total polyphenols in different spices and herbs are summarized...
September 15, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28902171/a-possible-indicator-of-oxidative-damage-in-smokers-13z-lycopene
#11
Daniel L Graham, Mario Lorenz, Andrew J Young, Gordon M Lowe
In vitro, the gaseous phase of cigarette smoke is known to induce both isomerization and degradation of dietary carotenoids, such as β-carotene and lycopene. However, the effects of cigarette smoke on the composition of circulating lycopene in vivo are not well understood. In this study, we examined the lycopene profiles of plasma from non-smokers and smokers. No oxidative intermediates of lycopene that have been observed previously in vitro were detected in the plasma, but evidence of isomerization of the carotenoid was seen...
September 13, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28829363/solanum-trilobatum-l-ameliorate-thioacetamide-induced-oxidative-stress-and-hepatic-damage-in-albino-rats
#12
Kumar Ganesan, Kumeshini Sukalingam, Baojun Xu
Solanum trilobatum L. (Solanaceae) has been well known as nightshade, commonly used by diverse populations to heal several disorders. Earlier studies in Solanum trilobatum were focused on different pharmacological activities and a few were concerned with antioxidant and hepatoprotective effects. Thus, the current study was focused to evaluate the antioxidant potential and hepatoprotective effects of S. trilobatum L. on thioacetamide (TAA) intoxication in Wistar albino rats. The rats were kept into four groups and six animals each...
August 22, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28829349/development-of-a-rapid-method-for-the-determination-of-caffeine-in-coffee-grains-by-gc-fid-a-fully-validated-approach
#13
Ioannis N Pasias, I Kiriakou, Charalampos Proestos
A simple method for the determination of caffeine in coffee grains by GC-FID (Gas Chromatography-Flame Ionisation Detector) is presented in the current work. The method was fully validated according to ISO (International Organization for Standardization) 17025 requirements and European Commission regulations. The accuracy, as provided by recovery experiments, was higher than 93%, and the precision, as provided by the (%) relative standard deviation under reproducibility conditions, was lower than 5%. A vast number of independent parameters that lead in the increase of uncertainty of methods were investigated...
August 22, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28825637/superoxide-dismutases-in-pancreatic-cancer
#14
REVIEW
Justin G Wilkes, Matthew S Alexander, Joseph J Cullen
The incidence of pancreatic cancer is increasing as the population ages but treatment advancements continue to lag far behind. The majority of pancreatic cancer patients have a K-ras oncogene mutation causing a shift in the redox state of the cell, favoring malignant proliferation. This mutation is believed to lead to nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation and superoxide overproduction, generating tumorigenic behavior. Superoxide dismutases (SODs) have been studied for their ability to manage the oxidative state of the cell by dismuting superoxide and inhibiting signals for pancreatic cancer growth...
August 19, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28820437/are-astrocytes-the-predominant-cell-type-for-activation-of-nrf2-in-aging-and-neurodegeneration
#15
REVIEW
Jeffrey R Liddell
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates hundreds of antioxidant genes, and is activated in response to oxidative stress. Given that many neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease and multiple sclerosis are characterised by oxidative stress, Nrf2 is commonly activated in these diseases. Evidence demonstrates that Nrf2 activity is repressed in neurons in vitro, and only cultured astrocytes respond strongly to Nrf2 inducers, leading to the interpretation that Nrf2 signalling is largely restricted to astrocytes...
August 18, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28805683/analysis-and-comparison-of-the-antioxidant-component-of-portulaca-oleracea-leaves-obtained-by-different-solid-liquid-extraction-techniques
#16
Monica Gallo, Esterina Conte, Daniele Naviglio
Portulaca oleracea is a wild plant pest of orchards and gardens, but is also an edible vegetable rich in beneficial nutrients. It possesses many antioxidant properties due to the high content of vitamins, minerals, omega-3 essential fatty acids and other healthful compounds; therefore, the intake of purslane and/or its bioactive compounds could help to improve the health and function of the whole human organism. Accordingly, in this work it was analyzed and compared to the extractive capacity of the antioxidant component of purslane leaves obtained by solid-liquid extraction techniques such as: hot-maceration, maceration with ultrasound, rapid solid-liquid dynamic extraction using the Naviglio extractor, and a combination of two techniques (mix extraction)...
August 12, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28796154/the-ability-of-exercise-associated-oxidative-stress-to-trigger-redox-sensitive-signalling-responses
#17
REVIEW
Richard Webb, Michael G Hughes, Andrew W Thomas, Keith Morris
In this review, we discuss exercise as an oxidative stressor, and elucidate the mechanisms and downstream consequences of exercise-induced oxidative stress. Reactive oxygen species (ROS) are generated in the mitochondria of contracting skeletal myocytes; also, their diffusion across the myocyte membrane allows their transport to neighbouring muscle tissue and to other regions of the body. Although very intense exercise can induce oxidative damage within myocytes, the magnitudes of moderate-intensity exercise-associated increases in ROS are quite modest (~two-fold increases in intracellular and extracellular ROS concentrations during exercise), and so the effects of such increases are likely to involve redox-sensitive signalling effects rather than oxidative damage...
August 10, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28771173/fate-and-prediction-of-phenolic-secoiridoid-compounds-throughout-the-different-stages-of-the-virgin-olive-oil-making-process
#18
Giuseppe Fregapane, M Desamparados Salvador
The evolution of the main phenolic secoiridoid compounds throughout the different stages of the virgin olive oil making process-crushing, malaxation and liquid-solid separation-is studied here, with the goal of making possible the prediction of the partition and transformation that take place in the different steps of the process. The concentration of hydroxytyrosol secoiridoids produced under the different crushing conditions studied are reasonably proportional to the intensity of the milling stage, and strongly depend on the olive variety processed...
August 3, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28771170/cysteine-glutathione-and-thiol-redox-balance-in-astrocytes
#19
REVIEW
Gethin J McBean
This review discusses the current understanding of cysteine and glutathione redox balance in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte activation on pathways that provide cysteine as a precursor for glutathione. The effect of the disruption of thiol-containing amino acid metabolism on the antioxidant capacity of astrocytes is also discussed.
August 3, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28788071/fractioning-of-proanthocyanidins-of-uncaria-tomentosa-composition-and-structure-bioactivity-relationship
#20
Mirtha Navarro, William Zamora, Silvia Quesada, Gabriela Azofeifa, Diego Alvarado, Maria Monagas
In a previous study, the detailed low-molecular weight polyphenolic profile of the different plant parts (leaves, stem, bark and wood) of Uncaria tomentosa was reported, the leaves being the plant part with the highest phenolic content and presenting the most heterogenous proanthocyanidin composition. Further, cytotoxicity of leaves extracts in two cancer cell lines was also found to be higher than in the remaining parts of the plant. In the present study, fractioning of U. tomentosa leaves polyphenolic extracts was performed using Diaion(®) HP-20 resin and a detailed characterization and quantification of fractions (n = 5) was achieved using advanced analytical techniques such as Ultra-Performance Liquid Chromatography coupled with Electrospray Ionization and Triple Quadrupole (TQD) Tandem Mass Spectrometry (UPLC/TQ-ESI-MS) and (13)C-NMR...
July 28, 2017: Antioxidants (Basel, Switzerland)
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