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Antioxidants (Basel, Switzerland)

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https://www.readbyqxmd.com/read/28704938/nadph-oxidases-angiogenesis-and-peripheral-artery-disease
#1
REVIEW
Pradeep Manuneedhi Cholan, Siân P Cartland, Mary M Kavurma
Peripheral artery disease (PAD) is caused by narrowing of arteries in the limbs, normally occurring in the lower extremities, with severe cases resulting in amputation of the foot or leg. A potential approach for treatment is to stimulate the formation of new blood vessels to restore blood flow to limb tissues. This is a process called angiogenesis and involves the proliferation, migration, and differentiation of endothelial cells. Angiogenesis can be stimulated by reactive oxygen species (ROS), with NADPH oxidases (NOX) being a major source of ROS in endothelial cells...
July 12, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28704937/attenuation-of-red-blood-cell-storage-lesions-with-vitamin-c
#2
Kimberly Sanford, Bernard J Fisher, Evan Fowler, Alpha A Fowler, Ramesh Natarajan
Stored red blood cells (RBCs) undergo oxidative stress that induces deleterious metabolic, structural, biochemical, and molecular changes collectively referred to as "storage lesions". We hypothesized that vitamin C (VitC, reduced or oxidized) would reduce red cell storage lesions, thus prolonging their storage duration. Whole-blood-derived, leuko-reduced, SAGM (saline-adenine-glucose-mannitol)-preserved RBC concentrates were equally divided into four pediatric storage bags and the following additions made: (1) saline (saline); (2) 0...
July 12, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28698499/molecular-mechanisms-behind-free-radical-scavengers-function-against-oxidative-stress
#3
REVIEW
Fereshteh Ahmadinejad, Simon Geir Møller, Morteza Hashemzadeh-Chaleshtori, Gholamreza Bidkhori, Mohammad-Saeid Jami
Accumulating evidence shows that oxidative stress is involved in a wide variety of human diseases: rheumatoid arthritis, Alzheimer's disease, Parkinson's disease, cancers, etc. Here, we discuss the significance of oxidative conditions in different disease, with the focus on neurodegenerative disease including Parkinson's disease, which is mainly caused by oxidative stress. Reactive oxygen and nitrogen species (ROS and RNS, respectively), collectively known as RONS, are produced by cellular enzymes such as myeloperoxidase, NADPH-oxidase (nicotinamide adenine dinucleotide phosphate-oxidase) and nitric oxide synthase (NOS)...
July 10, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28698493/antifungal-and-antiochratoxigenic-activities-of-essential-oils-and-total-phenolic-extracts-a-comparative-study
#4
Rachelle El Khoury, Ali Atoui, Florence Mathieu, Hiba Kawtharani, Anthony El Khoury, Richard G Maroun, Andre El Khoury
This study is intended to prevent ochratoxin A (OTA) production by Aspergillus carbonarius S402 using essential oils (EOs) and total phenolic compounds extracted from plants and herbs. The EOs used in this study are the following: bay leaves, cumin, fenugreek, melissa, mint, and sage. As for the phenolic compounds, they were extracted from bay leaves, cumin, fenugreek, melissa, mint, sage, anise, chamomile, fennel, rosemary, and thyme. The experiments were conducted on Synthetic Grape Medium (SGM) medium at 28 °C for 4 days...
July 9, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28684719/reactive-oxygen-and-nitrogen-species-in-the-development-of-pulmonary-hypertension
#5
REVIEW
David J R Fulton, Xueyi Li, Zsuzsanna Bordan, Stephen Haigh, Austin Bentley, Feng Chen, Scott A Barman
Pulmonary arterial hypertension (PAH) is a progressive disease of the lung vasculature that involves the loss of endothelial function together with inappropriate smooth muscle cell growth, inflammation, and fibrosis. These changes underlie a progressive remodeling of blood vessels that alters flow and increases pulmonary blood pressure. Elevated pressures in the pulmonary artery imparts a chronic stress on the right ventricle which undergoes compensatory hypertrophy but eventually fails. How PAH develops remains incompletely understood and evidence for the altered production of reactive oxygen and nitrogen species (ROS, RNS respectively) in the pulmonary circulation has been well documented...
July 6, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28678174/possible-reactions-of-dietary-phenolic-compounds-with-salivary-nitrite-and-thiocyanate-in-the-stomach
#6
REVIEW
Umeo Takahama, Sachiko Hirota
Foods are mixed with saliva in the oral cavity and swallowed. While staying in the stomach, saliva is contentiously provided to mix with the ingested foods. Because a salivary component of nitrite is protonated to produce active nitrous acid at acidic pH, the redox reactions of nitrous acid with phenolic compounds in foods become possible in the stomach. In the reactions, nitrous acid is reduced to nitric oxide (•NO), producing various products from phenolic compounds. In the products, stable hydroxybezoyl benzofuranone derivatives, which are produced from quercetin and its 7-O-glucoside, are included...
July 5, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28671577/silencing-of-nrf2-reduces-the-expression-of-aldh1a1-and-aldh3a1-and-sensitizes-to-5-fu-in-pancreatic-cancer-cells
#7
Hong-Quan Duong, Kyu Sic You, Seunghoon Oh, Sahng-June Kwak, Yeon-Sun Seong
Pancreatic cancer remains an intractable cancer with a poor five-year survival rate, which requires new therapeutic modalities based on the biology of pancreatic oncogenesis. Nuclear factor E2 related factor-2 (NRF2), a key cytoprotective nuclear transcription factor, regulates antioxidant production, reduction, detoxification and drug efflux proteins. It also plays an essential role in cell homeostasis, cell proliferation and resistance to chemotherapy. We aimed to evaluate the possibility that modulation of NRF2 expression could be effective in the treatment of pancreatic cancer cells...
July 1, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28665311/antioxidant-activity-of-yichun-blue-honeysuckle-ybhs-berry-counteracts-ccl%C3%A2-induced-toxicity-in-liver-injury-model-of-mice
#8
Mian-Ying Wang, Madhuwanti Srinivasan, Subramanyam Dasari, Parnal Narvekar, Angela Lincy Prem Antony Samy, Venkata Satish Dontaraju, Lin Peng, Gary L Anderson, Gnanasekar Munirathinam
Yichun Blue Honeysuckle (YBHS) is reported to have a broad range of health benefits including protection against a number of chronic diseases. The objective of our study was to determine whether YBHS exhibits antioxidant activity, and if so, determine how it provides protection against oxidative stress. Eight-week old mice (25 male and 25 female) were randomized into five groups (n = 10 per group). YBHS extract (at 6.25%, 12.5%, or 25%) was administrated via intra-gastric tube to mice at 0.1 mL/10 g body weight once daily for 7 days...
June 30, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28661467/early-and-late-induction-of-kras-and-hras-proto-oncogenes-by-reactive-oxygen-species-in-primary-astrocytes
#9
Samantha Messina, Erika Di Zazzo, Bruno Moncharmont
Astrocytes, one of the predominant types of glial cells, function as both supportive and metabolic cells for the brain. Among mammalian tissues, the highest levels of p21(Ras) protein are detected in the brain. Here, we investigated the expression of KRAS and HRAS proto-oncogenes in primary astrocytes following acute oxidative stimulation. Reactive oxygen species (ROS) changed the expression of proto-oncogenes at both transcriptional and translational levels. De novo protein synthesis analysis measured approximate values of proteins half-life, ranging from 1-4 h, of the different H- and K- isoforms by western blot analysis...
June 29, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28661427/deletion-of-txnip-mitigates-high-fat-diet-impaired-angiogenesis-and-prevents-inflammation-in-a-mouse-model-of-critical-limb-ischemia
#10
Sally L Elshaer, Islam N Mohamed, Maha Coucha, Sara Altantawi, Wael Eldahshan, Megan L Bartasi, Ahmed Y Shanab, Renee Lorys, Azza B El-Remessy
BACKGROUND: Previous work demonstrated that high-fat diet (HFD) triggered thioredoxin-interacting protein (TXNIP) and that silencing TXNIP prevents diabetes-impaired vascular recovery. Here, we examine the impact of genetic deletion of TXNIP on HFD-impaired vascular recovery using hind limb ischemia model. METHODS: Wild type mice (WT, C57Bl/6) and TXNIP knockout mice (TKO) were fed either normal chow diet (WT-ND and TKO-ND) or 60% high-fat diet (WT-HFD and TKO-HFD)...
June 29, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28661424/vitamin-c-and-microvascular-dysfunction-in-systemic-inflammation
#11
REVIEW
Karel Tyml
Sepsis, life-threatening organ dysfunction caused by a dysfunctional host response to infection, is associated with high mortality. A promising strategy to improve the outcome is to inject patients intravenously with ascorbate (vitamin C). In animal models of sepsis, this injection improves survival and, among others, the microvascular function. This review examines our recent work addressing ascorbate's ability to inhibit arteriolar dysfunction and capillary plugging in sepsis. Arteriolar dysfunction includes impaired vasoconstriction/dilation (previously reviewed) and impaired conduction of vasoconstriction/dilation along the arteriole...
June 29, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28672789/evaluating-modern-techniques-for-the-extraction-and-characterisation-of-sunflower-hellianthus-annus-l-seeds-phenolics
#12
Panagiotis Zoumpoulakis, Vassilia J Sinanoglou, Eleni Siapi, George Heropoulos, Charalampos Proestos
Recently there is a great interest in using high energy techniques (HET) which involve microwave or ultrasound-assisted extraction (MAE and UAE) for isolation of natural bioactive compounds from plant foods. Such bioactive compounds are phenolics which were determined from sunflower (Helianthus annuus L.) kernels and hulls (defatted) utilising two different high energy extraction techniques, ultrasound and microwave assisted solvent extraction. All samples were characterised by ultra-high-performance liquid chromatography-electrospray ionization-mass spectrometry (UHPLC-ESI-MS)...
June 24, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28672782/vitamin-e-and-alzheimer-s-disease-is-it-time-for-personalized-medicine
#13
REVIEW
Breana Cervantes, Lynn M Ulatowski
For the last two decades, it has been hotly debated whether vitamin E-the major lipid-soluble antioxidant, which functions to maintain neurological integrity-is efficacious as a therapy for Alzheimer's disease. Several factors key to the debate, include (1) which of the eight naturally-occurring vitamin E forms should be used; (2) how combination treatments affect vitamin E efficacy; and (3) safety concerns that most-recently resurfaced after the results of the Selenium and vitamin E Cancer prevention trial SELECT prostate cancer trial...
June 24, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28617308/nox2-induced-activation-of-arginase-and-diabetes-induced-retinal-endothelial-cell-senescence
#14
Modesto Rojas, Tahira Lemtalsi, Haroldo A Toque, Zhimin Xu, David Fulton, Robert William Caldwell, Ruth B Caldwell
Increases in reactive oxygen species (ROS) and decreases in nitric oxide (NO) have been linked to vascular dysfunction during diabetic retinopathy (DR). Diabetes can reduce NO by increasing ROS and by increasing activity of arginase, which competes with nitric oxide synthase (NOS) for their commons substrate l-arginine. Increased ROS and decreased NO can cause premature endothelial cell (EC) senescence leading to defective vascular repair. We have previously demonstrated the involvement of NADPH oxidase 2 (NOX2)-derived ROS, decreased NO and overactive arginase in DR...
June 15, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28594389/the-role-of-nox4-and-trx2-in-angiogenesis-and-their-potential-cross-talk
#15
REVIEW
Chaofei Chen, Li Li, Huanjiao Jenny Zhou, Wang Min
The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family is the major source of reactive oxygen species (ROS) in the vascular system. In this family, NOX4, a constitutive active form of NOXs, plays an important role in angiogenesis. Thioredoxin 2 (TRX2) is a key mitochondrial redox protein that maintains normal protein function and also provides electrons to peroxiredoxin 3 (PRX3) to scavenge H₂O₂ in mitochondria. Angiogenesis, a process of new blood vessel formation, is involved in a variety of physiological processes and pathological conditions...
June 8, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28594364/undernutrition-and-overnutrition-burden-for-diseases-in-developing-countries-the-role-of-oxidative-stress-biomarkers-to-assess-disease-risk-and-interventional-strategies
#16
REVIEW
Francesca Mastorci, Cristina Vassalle, Kyriazoula Chatzianagnostou, Claudio Marabotti, Khawer Siddiqui, Ahmed Ould Eba, Soueid Ahmed Sidi Mhamed, Arun Bandopadhyay, Marco Stefano Nazzaro, Mirko Passera, Alessandro Pingitore
The increased life expectancy, urbanization, and unhealthy lifestyle characterized by a shift towards a sedentary lifestyle and decreased energy expenditure are considered the main drivers of epidemiological transition. In particular, developing countries are facing a double burden caused by coexisting under- and over-nutrition, which causes a change in the disease profile from infectious diseases to a chronic degenerative pattern. This review discusses the under- and over-nutrition context in Mauritania and India, two countries that are experiencing a nutritional transition, and where we began a collaboration with local medical staff to integrate interventional and diagnostic guidelines...
June 8, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28587189/roles-of-nicotinamide-adenine-dinucleotide-phosphate-nadph-oxidase-in-angiogenesis-isoform-specific-effects
#17
REVIEW
Haibo Wang, M Elizabeth Hartnett
Angiogenesis is the formation of new blood vessels from preexisting ones and is implicated in physiologic vascular development, pathologic blood vessel growth, and vascular restoration. This is in contrast to vasculogenesis, which is de novo growth of vessels from vascular precursors, or from vascular repair that occurs when circulating endothelial progenitor cells home into an area and develop into blood vessels. The objective of this review is to discuss the isoform-specific role of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) in physiologic and pathologic angiogenesis and vascular repair, but will not specifically address vasculogenesis...
June 3, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28587060/is-root-catalase-a-bifunctional-catalase-peroxidase
#18
Vasileia Chioti, George Zervoudakis
Plant catalases exhibit spatial and temporal distribution of their activity. Moreover, except from the typical monofunctional catalase, a bifunctional catalase-peroxidase has been reported. The aim of this study was to investigate whether the leaf and root catalases from six different plant species (Lactuca sativa, Cichorium endivia, Apium graveolens, Petroselinum crispum, Lycopersicon esculentum, and Solanum melongena) correspond to the monofunctional or the bifunctional type based on their sensitivity to the inhibitor 3-amino-1,2,4-triazole (3-AT)...
May 25, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28545257/the-reactive-sulfur-species-concept-15-years-on
#19
REVIEW
Gregory I Giles, Muhammad Jawad Nasim, Wesam Ali, Claus Jacob
Fifteen years ago, in 2001, the concept of "Reactive Sulfur Species" or RSS was advocated as a working hypothesis. Since then various organic as well as inorganic RSS have attracted considerable interest and stimulated many new and often unexpected avenues in research and product development. During this time, it has become apparent that molecules with sulfur-containing functional groups are not just the passive "victims" of oxidative stress or simple conveyors of signals in cells, but can also be stressors in their own right, with pivotal roles in cellular function and homeostasis...
May 23, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28531132/effects-of-%C3%AE-carotene-and-its-cleavage-products-in-primary-pneumocyte-type-ii-cells
#20
Cornelia Haider, Franziska Ferk, Ekramije Bojaxhi, Giuseppe Martano, Hanno Stutz, Nikolaus Bresgen, Siegfried Knasmüller, Avdulla Alija, Peter M Eckl
β-Carotene has been shown to increase the risk of developing lung cancer in smokers and asbestos workers in two large scale trails, the Beta-Carotene and Retinol Efficacy Trial (CARET) and the Alpha-Tocopherol Beta-carotene Cancer Prevention Trial (ATBC). Based on this observation, it was proposed that genotoxic oxidative breakdown products may cause this effect. In support of this assumption, increased levels of sister chromatid exchanges, micronuclei, and chromosomal aberrations were found in primary hepatocyte cultures treated with a mixture of cleavage products (CPs) and the major product apo-8'carotenal...
May 21, 2017: Antioxidants (Basel, Switzerland)
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