journal
MENU ▼
Read by QxMD icon Read
search

Nature Microbiology

journal
https://www.readbyqxmd.com/read/28530667/host-response-neurons-loosen-the-grip-of-death
#1
Katherine B Ragan, Jason W Upton
No abstract text is available yet for this article.
May 22, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28530656/metabolic-anticipation-in-mycobacterium-tuberculosis
#2
Hyungjin Eoh, Zhe Wang, Emilie Layre, Poonam Rath, Roxanne Morris, D Branch Moody, Kyu Y Rhee
Humans serve as both host and reservoir for Mycobacterium tuberculosis, making tuberculosis a theoretically eradicable disease. How M. tuberculosis alternates between host-imposed quiescence and sporadic bouts of replication to complete its life cycle, however, remains unknown. Here, we identify a metabolic adaptation that is triggered upon entry into hypoxia-induced quiescence but facilitates subsequent cell cycle re-entry. Catabolic remodelling of the cell surface trehalose mycolates of M. tuberculosis specifically generates metabolic intermediates reserved for re-initiation of peptidoglycan biosynthesis...
May 22, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28530651/surface-attached-molecules-control-staphylococcus-aureus-quorum-sensing-and-biofilm-development
#3
Minyoung Kevin Kim, Aishan Zhao, Ashley Wang, Zachary Z Brown, Tom W Muir, Howard A Stone, Bonnie L Bassler
Bacteria use a process called quorum sensing to communicate and orchestrate collective behaviours, including virulence factor secretion and biofilm formation. Quorum sensing relies on the production, release, accumulation and population-wide detection of signal molecules called autoinducers. Here, we develop concepts to coat surfaces with quorum-sensing-manipulation molecules as a method to control collective behaviours. We probe this strategy using Staphylococcus aureus. Pro- and anti-quorum-sensing molecules can be covalently attached to surfaces using click chemistry, where they retain their abilities to influence bacterial behaviours...
May 22, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28530650/multi-virion-infectious-units-arise-from-free-viral-particles-in-an-enveloped-virus
#4
José M Cuevas, María Durán-Moreno, Rafael Sanjuán
Many animal viruses are enveloped in a lipid bilayer taken up from cellular membranes. Because viral surface proteins bind to these membranes to initiate infection, we hypothesized that free virions may also be capable of interacting with the envelopes of other virions extracellularly. Here, we demonstrate this hypothesis in the vesicular stomatitis virus (VSV), a prototypic negative-strand RNA virus composed of an internal ribonucleocapsid, a matrix protein and an external envelope(1). Using microscopy, dynamic light scattering, differential centrifugation and flow cytometry, we show that free viral particles can spontaneously aggregate into multi-virion infectious units...
May 22, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28504670/longevity-of-major-coenzymes-allows-minimal-de-novo-synthesis-in-microorganisms
#5
Johannes Hartl, Patrick Kiefer, Fabian Meyer, Julia A Vorholt
Coenzymes are vital for cellular metabolism and act on the full spectrum of enzymatic reactions. Intrinsic chemical reactivity, enzyme promiscuity and high flux through their catalytic cycles make coenzymes prone to damage. To counteract such compromising factors and ensure stable levels of functional coenzymes, cells use a complex interplay between de novo synthesis, salvage, repair and degradation. However, the relative contribution of these factors is currently unknown, as is the overall stability of coenzymes in the cell...
May 15, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28504669/nitric-oxide-prevents-a-pathogen-permissive-granulocytic-inflammation-during-tuberculosis
#6
Bibhuti B Mishra, Rustin R Lovewell, Andrew J Olive, Guoliang Zhang, Wenfei Wang, Eliseo Eugenin, Clare M Smith, Jia Yao Phuah, Jarukit E Long, Michelle L Dubuke, Samantha G Palace, Jon D Goguen, Richard E Baker, Subhalaxmi Nambi, Rabinarayan Mishra, Matthew G Booty, Christina E Baer, Scott A Shaffer, Veronique Dartois, Beth A McCormick, Xinchun Chen, Christopher M Sassetti
Nitric oxide contributes to protection from tuberculosis. It is generally assumed that this protection is due to direct inhibition of Mycobacterium tuberculosis growth, which prevents subsequent pathological inflammation. In contrast, we report that nitric oxide primarily protects mice by repressing an interleukin-1- and 12/15-lipoxygenase-dependent neutrophil recruitment cascade that promotes bacterial replication. Using M. tuberculosis mutants as indicators of the pathogen's environment, we inferred that granulocytic inflammation generates a nutrient-replete niche that supports M...
May 15, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28504659/structure-of-the-macab-tolc-abc-type-tripartite-multidrug-efflux-pump
#7
Anthony W P Fitzpatrick, Salomé Llabrés, Arthur Neuberger, James N Blaza, Xiao-Chen Bai, Ui Okada, Satoshi Murakami, Hendrik W van Veen, Ulrich Zachariae, Sjors H W Scheres, Ben F Luisi, Dijun Du
The MacA-MacB-TolC assembly of Escherichia coli is a transmembrane machine that spans the cell envelope and actively extrudes substrates, including macrolide antibiotics and polypeptide virulence factors. These transport processes are energized by the ATPase MacB, a member of the ATP-binding cassette (ABC) superfamily. We present an electron cryo-microscopy structure of the ABC-type tripartite assembly at near-atomic resolution. A hexamer of the periplasmic protein MacA bridges between a TolC trimer in the outer membrane and a MacB dimer in the inner membrane, generating a quaternary structure with a central channel for substrate translocation...
May 15, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28481361/linear-ubiquitination-of-cytosolic-salmonella-typhimurium-activates-nf-%C3%AE%C2%BAb-and-restricts-bacterial-proliferation
#8
Sjoerd J L van Wijk, Franziska Fricke, Lina Herhaus, Jalaj Gupta, Katharina Hötte, Francesco Pampaloni, Paolo Grumati, Manuel Kaulich, Yu-Shin Sou, Masaaki Komatsu, Florian R Greten, Simone Fulda, Mike Heilemann, Ivan Dikic
Ubiquitination of invading Salmonella Typhimurium triggers autophagy of cytosolic bacteria and restricts their spread in epithelial cells. Ubiquitin (Ub) chains recruit autophagy receptors such as p62/SQSTM1, NDP52/CALCOCO and optineurin (OPTN), which initiate the formation of double-membrane autophagosomal structures and lysosomal destruction in a process known as xenophagy. Besides this, the functional consequences and mechanistic regulation of differentially linked Ub chains at the host-Salmonella interface have remained unexplored...
May 8, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28481333/regulation-of-pfemp1-var2csa-translation-by-a-plasmodium-translation-enhancing-factor
#9
Sherwin Chan, Alejandra Frasch, Chandra Sekhar Mandava, Jun-Hong Ch'ng, Maria Del Pilar Quintana, Mattias Vesterlund, Mehdi Ghorbal, Nicolas Joannin, Oscar Franzén, Jose-Juan Lopez-Rubio, Sonia Barbieri, Antonio Lanzavecchia, Suparna Sanyal, Mats Wahlgren
Pregnancy-associated malaria commonly involves the binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate A (CSA) through the PfEMP1-VAR2CSA protein. VAR2CSA is translationally repressed by an upstream open reading frame. In this study, we report that the P. falciparum translation enhancing factor (PTEF) relieves upstream open reading frame repression and thereby facilitates VAR2CSA translation. VAR2CSA protein levels in var2csa-transcribing parasites are dependent on the expression level of PTEF, and the alleviation of upstream open reading frame repression requires the proteolytic processing of PTEF by PfCalpain...
May 8, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28481331/lubac-synthesized-linear-ubiquitin-chains-restrict-cytosol-invading-bacteria-by-activating-autophagy-and-nf-%C3%AE%C2%BAb
#10
Jessica Noad, Alexander von der Malsburg, Claudio Pathe, Martin A Michel, David Komander, Felix Randow
Cell-autonomous immunity relies on the ubiquitin coat surrounding cytosol-invading bacteria functioning as an 'eat-me' signal for xenophagy. The origin, composition and precise mode of action of the ubiquitin coat remain incompletely understood. Here, by studying Salmonella Typhimurium, we show that the E3 ligase LUBAC generates linear (M1-linked) polyubiquitin patches in the ubiquitin coat, which serve as antibacterial and pro-inflammatory signalling platforms. LUBAC is recruited via its subunit HOIP to bacterial surfaces that are no longer shielded by host membranes and are already displaying ubiquitin, suggesting that LUBAC amplifies and refashions the ubiquitin coat...
May 8, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28452987/variability-and-host-density-independence-in-inductions-based-estimates-of-environmental-lysogeny
#11
Ben Knowles, Barbara Bailey, Lance Boling, Mya Breitbart, Ana Cobián-Güemes, Javier Del Campo, Rob Edwards, Ben Felts, Juris Grasis, Andreas F Haas, Parag Katira, Linda Wegley Kelly, Antoni Luque, Jim Nulton, Lauren Paul, Gregory Peters, Nate Robinett, Stuart Sandin, Anca Segall, Cynthia Silveira, Merry Youle, Forest Rohwer
Temperate bacterial viruses (phages) may enter a symbiosis with their host cell, forming a unit called a lysogen. Infection and viral replication are disassociated in lysogens until an induction event such as DNA damage occurs, triggering viral-mediated lysis. The lysogen-lytic viral reproduction switch is central to viral ecology, with diverse ecosystem impacts. It has been argued that lysogeny is favoured in phages at low host densities. This paradigm is based on the fraction of chemically inducible cells (FCIC) lysogeny proxy determined using DNA-damaging mitomycin C inductions...
April 28, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28452986/vaccines-science-and-trust
#12
Bart Penders
No abstract text is available yet for this article.
April 28, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28452983/convergent-evolution-of-a-modified-acetate-driven-tca-cycle-in-bacteria
#13
Waldan K Kwong, Hao Zheng, Nancy A Moran
The tricarboxylic acid (TCA) cycle is central to energy production and biosynthetic precursor synthesis in aerobic organisms. There are few known variations of a complete TCA cycle, with the common notion being that the enzymes involved have already evolved towards optimal performance. Here, we present evidence that an alternative TCA cycle, in which acetate:succinate CoA-transferase (ASCT) replaces the enzymatic step typically performed by succinyl-CoA synthetase (SCS), has arisen in diverse bacterial groups, including microbial symbionts of animals such as humans and insects...
April 28, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28452981/host-response-pregnancy-impairs-flu-defences
#14
Elodie Ghedin, Stacey Schultz-Cherry
No abstract text is available yet for this article.
April 28, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28452979/structural-basis-for-%C3%AE-n-dependent-processive-transcription-antitermination
#15
Nelly Said, Ferdinand Krupp, Ekaterina Anedchenko, Karine F Santos, Olexandr Dybkov, Yong-Heng Huang, Chung-Tien Lee, Bernhard Loll, Elmar Behrmann, Jörg Bürger, Thorsten Mielke, Justus Loerke, Henning Urlaub, Christian M T Spahn, Gert Weber, Markus C Wahl
λN-mediated processive antitermination constitutes a paradigmatic transcription regulatory event, during which phage protein λN, host factors NusA, NusB, NusE and NusG, and an RNA nut site render elongating RNA polymerase termination-resistant. The structural basis of the process has so far remained elusive. Here we describe a crystal structure of a λN-NusA-NusB-NusE-nut site complex and an electron cryo-microscopic structure of a complete transcription antitermination complex, comprising RNA polymerase, DNA, nut site RNA, all Nus factors and λN, validated by crosslinking/mass spectrometry...
April 28, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28440298/making-medicines-that-save-lives
#16
Nonia Pariente
No abstract text is available yet for this article.
April 25, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28440290/counter-resistance
#17
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
April 25, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28440278/an-insider-s-perspective-bacteroides-as-a-window-into-the-microbiome
#18
REVIEW
Aaron G Wexler, Andrew L Goodman
Over the last decade, our appreciation for the contribution of resident gut microorganisms-the gut microbiota-to human health has surged. However, progress is limited by the sheer diversity and complexity of these microbial communities. Compounding the challenge, the majority of our commensal microorganisms are not close relatives of Escherichia coli or other model organisms and have eluded culturing and manipulation in the laboratory. In this Review, we discuss how over a century of study of the readily cultured, genetically tractable human gut Bacteroides has revealed important insights into the biochemistry, genomics and ecology that make a gut bacterium a gut bacterium...
April 25, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28440277/questioning-antiviral-rnai-in-mammals
#19
Benjamin R tenOever
No abstract text is available yet for this article.
April 25, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28440276/next-generation-probiotics-the-spectrum-from-probiotics-to-live-biotherapeutics
#20
Paul W O'Toole, Julian R Marchesi, Colin Hill
The leading probiotics currently available to consumers are generally drawn from a narrow range of organisms. Knowledge of the gut microbiota and its constituent actors is changing this paradigm, particularly given the phylogenetic range and relatively unknown characteristics of the organisms under investigation as novel therapeutics. For this reason, and because their development is likely to be more amenable to a pharmaceutical than a food delivery route, these organisms are often operationally referred to as next-generation probiotics, a concept that overlaps with the emerging concept of live biotherapeutic products...
April 25, 2017: Nature Microbiology
journal
journal
52752
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"