journal
MENU ▼
Read by QxMD icon Read
search

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

journal
https://www.readbyqxmd.com/read/28730183/aberrant-cerebellar-connectivity-in-bipolar-disorder-with-psychosis
#1
Ann K Shinn, Youkyung S Roh, Caitlin T Ravichandran, Justin T Baker, Dost Öngür, Bruce M Cohen
BACKGROUND: The cerebellum, which modulates affect and cognition in addition to motor functions, may contribute substantially to the pathophysiology of mood and psychotic disorders, such as bipolar disorder. A growing literature points to cerebellar abnormalities in bipolar disorder. However, no studies have investigated the topographic representations of resting state cerebellar networks in bipolar disorder, specifically their functional connectivity to cerebral cortical networks. METHODS: Using a well-defined cerebral cortical parcellation scheme as functional connectivity seeds, we compared ten cerebellar resting state networks in 49 patients with bipolar disorder and a lifetime history of psychotic features and 55 healthy control participants matched for age, sex, and image signal-to-noise ratio...
July 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28730182/tracking-deceased-related-thinking-with-neural-pattern-decoding-of-a-cortical-basal-ganglia-circuit
#2
Noam Schneck, Stefan Haufe, Tao Tu, George A Bonanno, Kevin Ochsner, Paul Sajda, J John Mann
BACKGROUND: Deceased-related thinking is central to grieving and potentially critical to processing of the loss. Self-report measurements might fail to capture important elements of deceased-related thinking and processing. Here, we used a machine learning approach applied to fMRI - known as neural decoding - to develop a measure of ongoing deceased-related processing. METHODS: 23 subjects grieving the loss of a first-degree relative, spouse or partner within 14 months underwent two fMRI tasks...
July 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28713866/implications-of-the-hierarchical-structure-of-psychopathology-for-psychiatric-neuroimaging
#3
David H Zald, Benjamin B Lahey
Research into the neurobiological substrates of psychopathology has been impeded by heterogeneity within diagnostic categories, comorbidity among mental disorders, and the presence of symptoms that transcend diagnostic categories. Solutions to these issues increasingly focus neurobiological research on isolated or narrow groupings of symptoms or functional constructs rather than categorical diagnoses. Here we argue for a more integrative approach that also incorporates the broad hierarchical structure of psychopathological symptoms and their etiological mechanisms...
May 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28584882/increases-in-intrinsic-thalamocortical-connectivity-and-overall-cognition-following-cognitive-remediation-in-chronic-schizophrenia
#4
Ian S Ramsay, Tasha M Nienow, Angus W MacDonald
BACKGROUND: Thalamic projections to the prefrontal cortex (PFC) are critical for cognition, and disruptions in these circuits are thought to underlie the pathophysiology of schizophrenia. Cognitive remediation (REM) is a behavioral intervention that holds promise for improving cognition and functioning in schizophrenia, however the extent to which it affects thalamo-prefrontal connections has not been researched. This study sought to determine whether patients with schizophrenia who undergo a placebo-controlled trial of REM show increased functional connectivity between the thalamus and PFC, and whether these changes correspond to improvements in cognition...
May 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28480336/longitudinal-relationships-among-activity-in-attention-redirection-neural-circuitry-and-symptom-severity-in-youth
#5
Michele A Bertocci, Genna Bebko, Amanda Dwojak, Satish Iyengar, Cecile D Ladouceur, Jay C Fournier, Amelia Versace, Susan B Perlman, Jorge R C Almeida, Michael J Travis, Mary Kay Gill, Lisa Bonar, Claudiu Schirda, Vaibhav A Diwadkar, Jeffrey L Sunshine, Scott K Holland, Robert A Kowatch, Boris Birmaher, David Axelson, Sarah M Horwitz, Thomas Frazier, L Eugene Arnold, Mary A Fristad, Eric A Youngstrom, Robert L Findling, Mary L Phillips
BACKGROUND: Changes in neural circuitry function may be associated with longitudinal changes in psychiatric symptom severity. Identification of these relationships may aid in elucidating the neural basis of psychiatric symptom evolution over time. We aimed to distinguish these relationships using data from the Longitudinal Assessment of Manic Symptoms (LAMS) cohort. METHODS: Forty-one youth completed two study visits (mean=21.3 months). Elastic-net regression (Multiple response Gaussian family) identified emotional regulation neural circuitry that changed in association with changes in depression, mania, anxiety, affect lability, and positive mood and energy dysregulation, accounting for clinical and demographic variables...
May 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28435932/default-mode-network-subsystems-are-differentially-disrupted-in-posttraumatic-stress-disorder
#6
Danielle R Miller, Scott M Hayes, Jasmeet P Hayes, Jeffrey M Spielberg, Ginette Lafleche, Mieke Verfaellie
BACKGROUND: Posttraumatic stress disorder (PTSD) is a psychiatric disorder characterized by debilitating re-experiencing, avoidance, and hyperarousal symptoms following trauma exposure. Recent evidence suggests that individuals with PTSD show disrupted functional connectivity in the default mode network, an intrinsic network that consists of a midline core, a medial temporal lobe (MTL) subsystem, and a dorsomedial prefrontal cortex (dMPFC) subsystem. The present study examined whether functional connectivity in these subsystems is differentially disrupted in PTSD...
May 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28670630/impaired-suppression-of-delay-period-alpha-and-beta-is-associated-with-impaired-working-memory-in-schizophrenia
#7
Molly A Erickson, Matthew A Albrecht, Benjamin Robinson, Steven J Luck, James M Gold
BACKGROUND: Although people with schizophrenia (PSZ) frequently exhibit reduced working memory capacity relative to healthy comparison subjects (HCS), the mechanisms that underlie this impairment are not yet known. The present study aimed to assess one putative mechanism: impaired suppression of alpha and beta frequency bands during the delay period of a visual working memory task. METHODS: The electroencephalogram (EEG) was recorded from 30 PSZ and 31 HCS while they completed a change detection task in which they were required to remember a briefly presented array of colored squares over an 1800-ms delay interval...
April 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28435933/the-c677t-variant-in-mthfr-modulates-associations-between-brain-integrity-mood-and-cognitive-functioning-in-old-age
#8
Florence F Roussotte, Xue Hua, Katherine L Narr, Gary W Small, Paul M Thompson
INTRODUCTION: The C677T functional variant in the methylene-tetrahydrofolate reductase (MTHFR) gene leads to reduced enzymatic activity and elevated blood levels of homocysteine. Hyperhomocysteinemia has been linked with higher rates of cardiovascular diseases, cognitive decline, and late-life depression. METHODS AND MATERIALS: Here, 3D magnetic resonance imaging data was analyzed from 738 individuals (age: 75.5 ± 6.8 years; 438 men/300 women) including 173 Alzheimer's patients, 359 subjects with mild cognitive impairment, and 206 healthy older adults, scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI)...
April 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28424797/magnetoencephalography-as-a-tool-in-psychiatric-research-current-status-and-perspective
#9
REVIEW
Peter J Uhlhaas, Peter Liddle, David E J Linden, Anna C Nobre, Krish D Singh, Joachim Gross
The application of neuroimaging to provide mechanistic insights into circuit dysfunctions in major psychiatric conditions and the development of biomarkers are core challenges in current psychiatric research. We propose that recent technological and analytic advances in magnetoencephalography (MEG), a technique that allows measurement of neuronal events directly and noninvasively with millisecond resolution, provides novel opportunities to address these fundamental questions. Because of its potential in delineating normal and abnormal brain dynamics, we propose that MEG provides a crucial tool to advance our understanding of pathophysiological mechanisms of major neuropsychiatric conditions, such as schizophrenia, autism spectrum disorders, and the dementias...
April 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28736755/risky-decision-making-in-neurofibromatosis-type-1-an-exploratory-study
#10
Rachel K Jonas, EunJi Roh, Caroline A Montojo, Laura A Pacheco, Tena Rosser, Alcino J Silva, Carrie E Bearden
BACKGROUND: Neurofibromatosis type 1 (NF1) is a monogenic disorder affecting cognitive function. About one third of children with NF1 have attentional disorders, and the cognitive phenotype is characterized by impairment in prefrontally-mediated functions. Mouse models of NF1 show irregularities in GABA release and striatal dopamine metabolism. We hypothesized that youth with NF1 would show abnormal behavior and neural activity on a task of risk-taking reliant on prefrontal-striatal circuits...
March 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28503670/encoding-of-contextual-fear-memory-requires-de-novo-proteins-in-the-prelimbic-cortex
#11
Valerio Rizzo, Khalid Touzani, Bindu L Raveendra, Supriya Swarnkar, Joan Lora, Beena M Kadakkuzha, Xin-An Liu, Chao Zhang, Doron Betel, Robert W Stackman, Sathyanarayanan V Puthanveettil
BACKGROUND: Despite our understanding of the significance of the prefrontal cortex in the consolidation of long-term memories (LTM), its role in the encoding of LTM remains elusive. Here we investigated the role of new protein synthesis in the mouse medial prefrontal cortex (mPFC) in encoding contextual fear memory. METHODS: Because a change in the association of mRNAs to polyribosomes is an indicator of new protein synthesis, we assessed the changes in polyribosome-associated mRNAs in the mPFC following contextual fear conditioning (CFC) in the mouse...
March 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28367515/shared-microstructural-features-of-behavioral-and-substance-addictions-revealed-in-areas-of-crossing-fibers
#12
Sarah W Yip, Kristen P Morie, Jiansong Xu, R Todd Constable, Robert T Malison, Kathleen M Carroll, Marc N Potenza
BACKGROUND: Similarities between behavioral and substance addictions exist. However, direct neurobiological comparison between addictive disorders is rare. Determination of disorder-specificity (or lack thereof) of alterations within white-matter microstructures will advance understanding of the pathophysiology of addictions. METHODS: We compared white-matter microstructural features between individuals with gambling disorder (GD; n=38), cocaine-use disorder (CUD; n=38) and healthy comparison (HC; n=38) participants, as assessed using diffusion-weighted magnetic resonance imaging (dMRI)...
March 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28367514/impulsive-antisocial-dimension-of-psychopathy-linked-to-enlargement-and-abnormal-functional-connectivity-of-the-striatum
#13
Cole Korponay, Maia Pujara, Philip Deming, Carissa Philippi, Jean Decety, David S Kosson, Kent A Kiehl, Michael Koenigs
BACKGROUND: Psychopathy is a mental health disorder characterized by callous and impulsive antisocial behavior, and is associated with a high incidence of violent crime, substance abuse, and recidivism. Recent studies suggest that the striatum may be a key component of the neurobiological basis for the disorder, though structural findings have been mixed and functional connectivity of the striatum in psychopathy has yet to be fully examined. METHODS: We performed a multimodal neuroimaging study of striatum volume and functional connectivity in psychopathy, using a large sample of adult male prison inmates (N=124)...
March 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28299368/modafinil-improves-episodic-memory-and-working-memory-cognition-in-patients-with-remitted-depression-a-double-blind-randomized-placebo-controlled-study
#14
Muzaffer Kaser, Julia B Deakin, Albert Michael, Camilo Zapata, Rachna Bansal, Dragana Ryan, Francesca Cormack, James B Rowe, Barbara J Sahakian
BACKGROUND: Cognitive dysfunction is a core feature of depression and tends to persist even after mood symptoms recover, leading to detrimental effects on clinical and functional outcomes. However, most currently available treatments have not typically addressed cognition. Modafinil has been shown to have beneficial effects on cognitive function and therefore has the potential to improve cognition in depression. The objective of this double-blind, placebo-controlled study was to investigate the effects of modafinil on cognitive functions in patients with remitted depression...
March 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28584881/thalamocortical-dysconnectivity-in-autism-spectrum-disorder-an-analysis-of-the-autism-brain-imaging-data-exchange
#15
Neil D Woodward, Monica Giraldo-Chica, Baxter Rogers, Carissa J Cascio
BACKGROUND: Individuals with autism spectrum disorder (ASD) exhibit differences in basic sensorimotor processing as well as general cortical excitability. These observations converge to implicate thalamocortical connectivity as a potential unifying neural mechanism. The goal of this study was to clarify mixed findings on thalamocortical functional connectivity in a large sample of individuals with ASD. METHODS: Using the Autism Brain Imaging Data Exchange (ABIDE), we examined thalamocortical functional connectivity in 228 individuals with ASD and a matched comparison group of 228 typically developing individuals...
January 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28497126/vulnerability-to-depression-in-youth-advances-from-affective-neuroscience
#16
Autumn Kujawa, Katie L Burkhouse
Vulnerability models of depression posit that individual differences in trait-like vulnerabilities emerge early in life and increase risk for the later development of depression. In this review, we summarize advances from affective neuroscience using neural measures to assess vulnerabilities in youth at high risk for depression due to parental history of depression or temperament style, as well as prospective designs evaluating the predictive validity of these vulnerabilities for symptoms and diagnoses of depression across development...
January 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28367513/categorical-versus-dimensional-approaches-to-autism-associated-intermediate-phenotypes-in-22q11-2-microdeletion-syndrome
#17
Maria Jalbrzikowski, Khwaja Hamzah Ahmed, Arati Patel, Rachel Jonas, Leila Kushan, Carolyn Chow, Carrie E Bearden
BACKGROUND: 22q11.2 Microdeletion syndrome (22q11DS) is associated with elevated rates of autism spectrum disorders (ASDs), although the diagnosis is controversial. In order to determine whether there is a biological substrate of ASD in 22q11DS, we examined neurocognitive and structural neuroanatomic differences between those with 22q11DS and an ASD diagnosis (22q11DS-ASD+) and those with 22q11DS without ASD (22q11DS-ASD-); we then determined whether these differences were better characterized within a categorical or dimensional framework...
January 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28217759/frontal-gamma-aminobutyric-acid-concentrations-are-associated-with-cognitive-performance-in-older-adults
#18
Eric C Porges, Adam J Woods, Richard A E Edden, Nicolaas A J Puts, Ashley D Harris, Huaihou Chen, Amanda M Garcia, Talia R Seider, Damon G Lamb, John B Williamson, Ronald A Cohen
BACKGROUND: Gamma-aminobutyric acid (GABA), the brain's principal inhibitory neurotransmitter, has been associated with perceptual and attentional functioning. Recent application of magnetic resonance spectroscopy (MRS) provides in vivo evidence for decreasing GABA concentrations during adulthood. It is unclear, however, how age-related decrements in cerebral GABA concentrations contribute to cognitive decline, or whether previously reported declines in cerebral GABA concentrations persist during healthy aging...
January 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28164168/doubling-down-increased-risk-taking-behavior-following-a-loss-by-individuals-with-cocaine-use-disorder-is-associated-with-striatal-and-anterior-cingulate-dysfunction
#19
Joshua L Gowin, April C May, Marc Wittmann, Susan F Tapert, Martin P Paulus
BACKGROUND: Cocaine use disorders (CUDs) have been associated with increased risk-taking behavior. Neuroimaging studies have suggested that altered activity in reward and decision-making circuitry may underlie cocaine user's heightened risk-taking. It remains unclear if this behavior is driven by greater reward salience, lack of appreciation of danger, or another deficit in risk-related processing. METHODS: Twenty-nine CUD participants and forty healthy comparison participants completed the Risky Gains Task during a functional magnetic resonance imaging scan...
January 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28255578/neuropil-pruning-in-early-course-schizophrenia-immunological-clinical-and-neurocognitive-correlates
#20
Konasale M Prasad, Ashley M Burgess, Matcheri S Keshavan, Vishwajit L Nimgaonkar, Jeffrey A Stanley
INTRODUCTION: Neuropathological studies suggest neuropil reduction in schizophrenia. Altered synaptic pruning is proposed to underlie neuropil reduction. Underlying factors and clinical correlates of synaptic pruning are poorly understood. Using phosphorus magnetic resonance spectroscopy ((31)P MRS), it is feasible to assess membrane phospholipid (MPL) metabolites in the brain that specifically and sensitively reflect neuropil expansion (elevated MPL precursors) or contraction (elevated MPL catabolites)...
November 2016: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
journal
journal
52708
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"