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Masaki Uto, Maomi Ueno
In various assessment contexts including entrance examinations, educational assessments, and personnel appraisal, performance assessment by raters has attracted much attention to measure higher order abilities of examinees. However, a persistent difficulty is that the ability measurement accuracy depends strongly on rater and task characteristics. To resolve this shortcoming, various item response theory (IRT) models that incorporate rater and task characteristic parameters have been proposed. However, because various models with different rater and task parameters exist, it is difficult to understand each model's features...
May 2018: Heliyon
Elina Kylmäoja, Miho Nakamura, Hanna Kokkonen-Puuperä, Veli-Pekka Ronkainen, Petri Lehenkari, Juha Tuukkanen
Aims: The aim of the study was to compare the influence of gap junctional communication (GJC) in osteoclastogenesis from bone marrow (BM) and peripheral blood (PB) monocytes. These widely used sources differ in purity, since BM cultures contain a significant number of stromal cells. We studied whether stimulation of GJC in BM monocyte/stromal cell cultures differs from the effect in pure PB monocyte cultures. We compared the differentiation also in acidosis, which is a known inducer of bone resorption...
May 2018: Heliyon
Grace R Murphy, R Hugh Dunstan, Margaret M Macdonald, Johan Gottfries, Tim K Roberts
Temperature and pH are known to vary in a wound site due to the immune response and subsequent healing processes. This study used a multifactorial design to examine the cellular responses of Staphylococcus aureus to hydrogen peroxide (0-100 mM) when bacteria were grown in temperatures of 37 ± 2 °C and pH 7 ± 1, conditions potentially encountered in wound sites. A centroid sample was included in the design which represented the mid-point values of all three environmental parameters (37 °C, pH 7, 50 mM H2 O2 )...
May 2018: Heliyon
Madhu Sudhana Saddala, Pradeepkiran Jangampalli Adi
Vivapain-3(VP-3) protein is a family of cysteine rich proteases of malaria parasite is extensively reported to participate in a range of wide cellular processes including survival. VP-3 of plasmodium recognized as an attractive drug target in vector-borne diseases like malaria. In the present study we robust a homology model of VP-3 protein and generated the pharmacophore based models adapted to screen the best drug like compounds from PubChem database. Our results finds the fourteen best lead molecules were mapped with core pharmacophore features of VP-3 and top hits were further evaluated by molecular dynamics simulation and docking studies...
May 2018: Heliyon
Congming Wu, Meiyin Yan, Lizhang Liu, Jing Lai, Edward Wai-Chi Chan, Sheng Chen
Food animals are major reservoirs from which specific pathogenic Salmonella strains emerge periodically. Probing the identity and origin of such organisms is essential for formulation of highly-focused infection control measures and analysis of factors underlying dissemination of such strains. In this work, the genetic and phenotypic features of animal and human clinical isolates collected at different geographical localities in China during the period 2003-2011 were characterized and compared. Animal-specific serotypes were identified, with S ...
April 2018: Heliyon
Nicholas R Nalli
U.S. President John F. Kennedy was assassinated while riding in an open motorcade by a sniper in Dallas, Texas on 22 November 1963. A civilian bystander, Mr. Abraham Zapruder, filmed the motorcade with a 8-mm home movie camera as it drove through Dealey Plaza, inadvertently recording an ≈8 second sequence of events that included a fatal gunshot wound to the President in the head. The accompanying backward motion of the President's head after impact appeared to support later "conspiracy theories" because it was claimed that this was proof of a shot from the front (in addition to one from behind)...
April 2018: Heliyon
Deniz Doruk, Lorena Chanes, Alejandra Malavera, Lotfi B Merabet, Antoni Valero-Cabré, Felipe Fregni
Objective: The impact of visuospatial attention on perception with supraliminal stimuli and stimuli at the threshold of conscious perception has been previously investigated. In this study, we assess the cross-modal effects of visuospatial attention on conscious perception for near-threshold somatosensory stimuli applied to the face. Methods: Fifteen healthy participants completed two sessions of a near-threshold cross-modality cue-target discrimination/conscious detection paradigm...
April 2018: Heliyon
C Lo Passo, L Zippilli, A Angiolillo, I Costa, I Pernice, R Galbo, F Felici, P T Beernink
Factor H binding protein (FHbp) is a component of two licensed vaccines for prevention of sepsis and meningitis caused by serogroup B meningococci. FHbp binds human Factor H (FH), which contributes to evasion of host immunity and FHbp sequence variants can be classified into two sub-families. Antibodies against FHbp elicit complement-mediated killing and can inhibit recruitment of FH to the bacterial surface. We report epitope mapping studies of two murine IgG mAbs, designated JAR 31 and JAR 36, isolated from a mouse immunized with FHbp in sub-family A, which is present in ∼30-40% of invasive isolates...
April 2018: Heliyon
Salam A Mohammed, Lamya Al Amouri, Emad Yousif, Ali Abd Ali, Fazal Mabood, Hazim F Abbas, Sausan Alyaqoobi
Vanadium oxide has been largely exploited as a catalyst in many industrial applications. In this article, we show the synthesis of vanadium oxide (V2 O5 ): Nickel Oxide (NiO) composite using sol-gel method at optimum conditions. The composite nanomaterials were used to remove methyl orange from waste water via harnessing the photocatalytic activity of it which showed an excellent efficiency of removal at 88%, and 93% after the exposure to the light, and light with heating respectively. This will pave the way into further implementation of these nanomaterials in the removal of some other dyes and contaminants from wastewater...
March 2018: Heliyon
Marisol C Camacho, Yolanda R Gallardo, Roberto Ch Stegun, Bruno Costa, Newton Sesma
Purpose: The purpose of this study was to evaluate the behavior of mandibular canines acting as abutment teeth and indirect retainers of a Kennedy class II according to different designs: lingual rest and lingual rest associated with a reciprocal arm. Materials & methods: A resin cast with two simulated canine teeth was made in Ni-Cr alloy, representing a Kennedy class II mandibular arch. With the objective of simulating the resilience of the periodontal ligament, a polyurethane layer was added at the canine tooth's root...
March 2018: Heliyon
Aung Zaw Oo, Shigeto Sudo, Khin Thuzar Win, Akira Shibata, Takeru Gonai
Two incubation experiments were conducted under controlled moisture and temperature conditions to determine the effects of soil amendment treatments based on pruning waste biochar and oyster shell, on N2 O and CO2 emissions from an orchard soil. In experiment 1, four treatments were tested including, control (CK), pruning waste biochar at 2% (B2%), at 10% (B10%), and oyster shell (OS), mixed with soil from two different depths, namely, from the 0-5 cm and the 0-10 cm layers. In experiment 2, only the 0-10 cm soil layer was used to study the effect of surface application of pruning waste biochar (B2% and B10%) on soil N2 O and CO2 emissions...
March 2018: Heliyon
Najib A Mozahem
Recently, researchers have started to pay more attention to a usually ignored topic: audience perceptions. Legitimacy, for example, is no longer modeled as the number of organizations in a population. It is now thought to be dependent on how audience members perceive these organizations. This paper will study how the newspaper industry in Lebanon emerged. The paper studies the period 1851-1879, building on the theoretic formulation of Hannan et al. (2007). The concept of cluster formation will also be introduced in order to help answer the question of whether unified identity projection is a necessary condition for successful legitimation and emergence...
March 2018: Heliyon
Nashi K Alqahtani, John Ashton, Lita Katopo, Elisabeth Gorczyca, Stefan Kasapis
Development of malodourous compounds, hexanal and p -vinyl guaiacol (PVG), in UHT model liquid systems fortified with wholegrain oat were evaluated. Single and mixed systems using oat powder (3, 5, and 7% w/w), skim milk powder (SMP, 2.8% w/w) and sucrose (6.7% w/w) were subjected to UHT treatment and 29 days ambient storage. Both chromatographic analyses and panellists' perceived aroma intensity show a positive relationship between the content of hexanal and PVG, storage time and oat concentrations trialled...
March 2018: Heliyon
Widodo, Nadya Veronica Margarecaesha Anyndita, Nurul Dluha, Muhaimin Rifa'i, Karimatul Himmah, Mulya Dwi Wahyuningsih
Background: Epstein-Barr virus (EBV) can cause cancer in people from around the world. There is no EBV vaccine available for use on a global scale. However, emerging evidence suggests that the epitope on the gp350/220 capsid protein may be developed into an EBV vaccine. Nevertheless, the production of small, single epitope is challenging of stability issues and possible alteration of peptide structure. In this study, a tandem epitope was developed consisting of three single epitopes, aimed to improve stability, antigenicity and preserve epitope structure...
March 2018: Heliyon
Richter Razafindratsimandresy, Ondrej Mach, Jean-Michel Heraud, Barivola Bernardson, William C Weldon, M Steven Oberste, Roland W Sutter
Background: Vaccine-derived polioviruses (VDPV) outbreaks typically occur in areas of low poliovirus immunity. Madagascar successfully eradicated wild poliovirus in 1997; however, multiple VDPV outbreaks have occurred since then, and numerous vaccination campaigns have been carried out to control the VDPV outbreaks. We conducted a survey of poliovirus neutralizing antibodies among Malagasy children to assess performance of vaccination campaigns and estimate the risk of future VDPV outbreaks...
March 2018: Heliyon
Priya Kapoor, Philip Murphy
Objectives: To evaluate the effect of antibiotic combination therapy versus single therapy against cystic fibrosis strains of Pseudomonas aeruginosa identified as common and rare among patient groups in different Irish hospitals. Methods: This study compares the susceptibility profiles of P. aeruginosa isolates from different cystic fibrosis (CF) clinics in Ireland, collected from 2004-2005. Strains were recovered in small numbers and typed by pulsed-field gel electrophoresis...
March 2018: Heliyon
Nguyen Bao Quoc, Nguyen Doan Nguyen Phuong, Nguyen Ngoc Bao Chau, Do Thi Phuong Linh
Recently, many studies have demonstrated the significant advantages of loop-mediated isothermal amplification (LAMP) based methods over serological tests and PCR for rapid detection of microbial pathogens. Here, a rapid LAMP assay was developed to detect the hepatitis B virus (HBV) from DNA, and particularly, blood samples from infected patients using a commercially available master mix and portable real-time fluorometer. The final optimized fluorescence-based LAMP assay provided significant amplification time of less than 15 minutes compared with over 1 hour for PCR and an opened tube LAMP system described previously...
March 2018: Heliyon
Irina Turku, Timo Kärki, Ari Puurtinen
The influence of accelerated weathering, xenon-arc light and freeze-thaw cycling on wood plastic composites extruded from a recycled plastic was studied. The results showed that, in general, weathering had a stronger impact on samples made from plastic waste compared to a sample made from virgin material. After weathering, the mechanical properties, tensile and flexural, were reduced by 2-30%, depending on the plastic source. Wettability of the samples was shown to play a significant role in their stability...
March 2018: Heliyon
Shimpei Morimoto, Koji Yahara
Protein expression is regulated by the production and degradation of mRNAs and proteins but the specifics of their relationship are controversial. Although technological advances have enabled genome-wide and time-series surveys of mRNA and protein abundance, recent studies have shown paradoxical results, with most statistical analyses being limited to linear correlation, or analysis of variance applied separately to mRNA and protein datasets. Here, using recently analyzed genome-wide time-series data, we have developed a statistical analysis framework for identifying which types of genes or biological gene groups have significant correlation between mRNA and protein abundance after accounting for potential time delays...
March 2018: Heliyon
Thomas D'huys, Sandra Claes, Tom Van Loy, Dominique Schols
Chemokine receptors CCR5 and CXCR4 are considered the main coreceptors for initial HIV infection, replication and transmission, and subsequent AIDS progression. Over the years, other chemokine receptors, belonging to the family of G protein-coupled receptors, have also been identified as candidate coreceptors for HIV entry into human host cells. Amongst them, CXCR7, also known as atypical chemokine receptor 3 (ACKR3), was suggested as a coreceptor candidate capable of facilitating both HIV-1 and HIV-2 entry in vitro ...
March 2018: Heliyon
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