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ERJ Open Research

Sara Roversi, Roberto Tonelli, Bianca Beghè, Federico Banchelli, Roberto D'Amico, Mario Malerba, Leonardo M Fabbri, Enrico M Clini
In real-life practice, acute exacerbation of COPD is often treated as a cardiopulmonary syndrome
July 2018: ERJ Open Research
Thierry Berghmans, Matthew Evison, Torsten Gerriet Blum, Nir Peled, Jacques Cadranel
In the last decade, systemic therapy for advanced lung cancer has become diverse, complex and personalised. These new therapies (monoclonal antibodies, tyrosine kinase inhibitors (TKIs) and immunotherapy) have a far different toxicity profile compared to chemotherapy. Furthermore, clinical indications and reimbursement criteria can vary across Europe. The aim of the present online survey was to assess the knowledge, views and challenges facing the European respiratory community in this rapidly changing field...
July 2018: ERJ Open Research
Gisli Thor Axelsson, Rachel K Putman, Ezra R Miller, Tetsuro Araki, Sigurdur Sigurdsson, Elias F Gudmundsson, Gudny Eiríksdottír, Kristin Siggeirsdottir, Thor Aspelund, Lenore J Launer, Tamara B Harris, Hiroto Hatabu, Vilmundur Gudnason, Gary M Hunninghake, Gunnar Gudmundsson
Reductions in objectively measured physical function are associated with interstitial lung abnormalities
July 2018: ERJ Open Research
Lucy Pembrey, Mauricio L Barreto, Jeroen Douwes, Philip Cooper, John Henderson, Harriet Mpairwe, Cristina Ardura-Garcia, Martha Chico, Collin Brooks, Alvaro A Cruz, Alison M Elliott, Camila A Figueiredo, Sinéad M Langan, Beatrice Nassanga, Susan Ring, Laura Rodrigues, Neil Pearce
The World Asthma Phenotypes (WASP) study started in 2016 and has been conducted in five centres, in the UK, New Zealand, Brazil, Ecuador and Uganda. The objectives of this study are to combine detailed biomarker and clinical information in order to 1) better understand and characterise asthma phenotypes in high-income countries (HICs) and low and middle-income countries (LMICs), and in high and low prevalence centres; 2) compare phenotype characteristics, including clinical severity; 3) assess the risk factors for each phenotype; and 4) assess how the distribution of phenotypes differs between high prevalence and low prevalence centres...
July 2018: ERJ Open Research
Olívia Meira Dias, Bruno Guedes Baldi, Jeferson George Ferreira, Letícia Zumpano Cardenas, Francesca Pennati, Caterina Salito, Carlos Roberto Ribeiro Carvalho, Andrea Aliverti, André Luis Pereira de Albuquerque
Small airway and interstitial pulmonary involvements are prominent in chronic hypersensitivity pneumonitis (cHP). However, their roles on exercise limitation and the relationship with functional lung tests have not been studied in detail. Our aim was to evaluate exercise performance and its determinants in cHP. We evaluated maximal cardiopulmonary exercise testing performance in 28 cHP patients (forced vital capacity 57±17% pred) and 18 healthy controls during cycling. Patients had reduced exercise performance with lower peak oxygen production (16...
July 2018: ERJ Open Research
Shutan Liao, Dongsheng Li, Zheng Hui, Craig S McLachlan, Yang Zhang
Pulmonary arterial hypertension (PAH) is a common complication of a congenital heart defect (CHD). Recent studies suggest metformin may be a potential drug to improve cardiac function in PAH. A pilot study was conducted to investigate the efficacy of short-term treatment with a combination regimen consisting of bosentan and metformin in PAH-CHD patients as compared with bosentan monotherapy in a prospective, randomised study. Patients with PAH-CHD were randomised to receive bosentan (initially at 62.5 mg twice daily for 4 weeks and then 125 mg twice daily) for 3 months with or without the combination treatment of metformin (500 mg twice daily)...
July 2018: ERJ Open Research
Tanel Laisaar, Bruno Sarana, Indrek Benno, Kaja-Triin Laisaar
Since publication of the National Lung Cancer Screening Trial (NLST) results early lung cancer detection has been widely studied, targeting individuals based on smoking history and age. However, over recent decades several changes in lung cancer epidemiology, including risk factors, have taken place. The aim of the current study was to explore smoking prevalence among lung cancer patients who had been treated surgically or undergone a diagnostic operation and whether these patients would have met the NLST inclusion criteria...
July 2018: ERJ Open Research
Yochai Adir, Omar Hakrush, Michal Shteinberg, Sonia Schneer, Alvar Agusti
Whether the level of circulating eosinophils in chronic obstructive pulmonary disease (COPD) patients can predict the risk of exacerbations of COPD (ECOPD) or response to treatment is debated. Here, we evaluate the prevalence of elevated eosinophils in COPD patients and its relationship with severe ECOPD requiring hospitalisation. We retrospectively reviewed the charts of COPD patients hospitalised in our centre between January 1, 2005 and November 30, 2015 because of ECOPD or other reasons (controls). In a second analysis, the ECOPD patients were divided into two subgroups based on having ECOPD in the next year after the index event or not...
July 2018: ERJ Open Research
Ana Kantorowski, Emily S Wan, Diana Homsy, Reema Kadri, Caroline R Richardson, Marilyn L Moy
Determinants of change in physical activity and outcomes of physical activity promotion are unclear. In this secondary analysis of a randomised controlled trial of a physical activity intervention, we assess predictors of change in physical activity and the effects of increasing physical activity on chronic obstructive pulmonary disease (COPD) measures. Physical activity was promoted in 94 subjects with COPD using the Omron HJ-720ITC pedometer alone or the pedometer plus a website that provides goal setting, feedback, motivational and educational messages, and social support for 3 months...
July 2018: ERJ Open Research
Tina Heyder, Emil Wiklundh, Anders Eklund, Anna James, Johan Grunewald, Roman A Zubarev, Susanna L Lundström
Characterising chronic lung diseases is challenging. New, less invasive diagnostics are needed to decipher disease pathologies and subphenotypes. Fc galactosylation is known to affect IgG function, and is altered in autoimmune disorders and under other pathological conditions. We tested how well Fc glycans in IgG from bronchoalveolar lavage fluid (BALF) and serum correlated, and if the Fc glycan profile could reveal pulmonary inflammation. A shotgun proteomics approach was used to profile Fc glycans in serum and BALF of controls (n=12) and sarcoidosis phenotypes (Löfgren's syndrome (LS), n=11; and non-LS, n=12)...
July 2018: ERJ Open Research
Dongbo Fu, Christina Gratziou, Carlos Jiménez-Ruiz, Marine Faure, Brian Ward, Sofia Ravara, Vinayak Mohan Prasad, Kristina Mauer-Stender, Jagdish Kaur, Angela Ciobanu, Syed Mahfuzul Huq, Paraskevi Katsaounou
Strategic @ERSTalk-@WHO alliance to address tobacco use by training health professionals on brief advice resulted in establishing smoking cessation in real care settings with quit rates higher than the literature and high propensity for wider dissemination
July 2018: ERJ Open Research
Pinelopi Anagnostopoulou, Nadja Kranz, Jeremias Wolfensberger, Marisa Guidi, Sylvia Nyilas, Cordula Koerner-Rettberg, Sophie Yammine, Florian Singer, Philipp Latzin
Lung clearance index (LCI) is the main outcome of the multiple-breath washout (MBW) test. Current recommendations for LCI acquisition are based on low-grade evidence. The aim of this study was to challenge those recommendations using alternative methods for LCI analysis. Nitrogen MBW measurements from school-aged children, 20 healthy controls, 20 with cystic fibrosis (CF) and 17 with primary ciliary dyskinesia (PCD), were analysed using 1) current algorithms (standard), 2) three alternative algorithms to detect with higher precision the end of MBW testing and 3) two alternative algorithms to determine exhaled tracer gas concentrations...
July 2018: ERJ Open Research
Nishta Kaushik, Chris Lowbridge, Gabriella Scandurra, Claudia C Dobler
Following pre-migration screening for tuberculosis (TB), migrants who are deemed to be at a high risk of developing TB must attend post-entry follow-up in Australia. We aimed to evaluate the effectiveness of post-migration TB follow-up in the state of New South Wales to diagnose TB in these high-risk migrants. In this retrospective cohort study, we assessed the risk of TB in migrants who arrived in New South Wales between 2000 and 2015 and were referred for post-migration follow-up. Clinical notes were examined for a nested cohort to determine whether TB was diagnosed via the follow-up programme or via passive case finding...
July 2018: ERJ Open Research
Moana Mika, Izabela Nita, Laura Morf, Weihong Qi, Seraina Beyeler, Eric Bernasconi, Benjamin J Marsland, Sebastian R Ott, Christophe von Garnier, Markus Hilty
Compartmentalisation of the respiratory tract microbiota in patients with different chronic obstructive pulmonary disease (COPD) severity degrees needs to be systematically investigated. In addition, it is unknown if the inflammatory and emphysematous milieux in patients with COPD are associated with changes in the respiratory tract microbiota and host macrophage gene expression. We performed a cross-sectional study to compare non-COPD controls (n=10) to COPD patients (n=32) with different disease severity degrees...
July 2018: ERJ Open Research
Kozo Morimoto, Akio Aono, Yoshiro Murase, Tsuyoshi Sekizuka, Atsuyuki Kurashima, Akiko Takaki, Yuka Sasaki, Yuriko Igarashi, Kinuyo Chikamatsu, Hajime Goto, Hiroyuki Yamada, Makoto Kuroda, Satoshi Mitarai
Reinfection of nontuberculous mycobacterium pulmonary disease may be caused by identical and not different genotypes
July 2018: ERJ Open Research
Frantzeska Frantzeskaki, Stylianos E Orfanos
A detailed and comprehensive summary of the ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia, published in ERJ Open Research , will assist clinicians in their tasks
April 2018: ERJ Open Research
Soumya Bhattacharjee, Prasun Haldar, Santi Gopal Maity, Smriti Debnath, Saibal Moitra, Sujoy Saha, Ritabrata Mitra, Isabella Annesi-Maesano, Judith Garcia-Aymerich, Subhabrata Moitra
Despite a considerable number of international reports on allergic diseases among children, information about the prevalence and risk factors of asthma and allergy-related diseases among Indian adolescents is relatively sparse. The Prevalence and Risk Factors of Asthma and Allergy-Related Diseases among Adolescents (PERFORMANCE) study has been conceived to study the aetiology of asthma and allergic diseases including rhinoconjunctivitis, atopic eczema and food allergies among adolescents in West Bengal, India, using standardised methods and collaborations...
April 2018: ERJ Open Research
Jessica L Tsui, Oscar A Estrada, Zimu Deng, Kristin M Wang, Christopher S Law, Brett M Elicker, Kirk D Jones, Sharon D Dell, Gunnar Gudmundsson, Sif Hansdottir, Simon M Helfgott, Stefano Volpi, Marco Gattorno, Michael R Waterfield, Alice Y Chan, Sharon A Chung, Brett Ley, Anthony K Shum
The COPA syndrome is a monogenic, autoimmune lung and joint disorder first identified in 2015. This study sought to define the main pulmonary features of the COPA syndrome in an international cohort of patients, analyse patient responses to treatment and highlight when genetic testing should be considered. We established a cohort of subjects (N=14) with COPA syndrome seen at multiple centres including the University of California, San Francisco, CA, USA. All subjects had one of the previously established mutations in the COPA gene, and had clinically apparent lung disease and arthritis...
April 2018: ERJ Open Research
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