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ERJ Open Research

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https://www.readbyqxmd.com/read/30443557/low-plasma-stem-cell-factor-combined-with-high-transforming-growth-factor-%C3%AE-identifies-high-risk-patients-in-pulmonary-arterial-hypertension
#1
Habib Bouzina, Göran Rådegran
In pulmonary arterial hypertension (PAH), severe vasoconstriction and remodelling of small pulmonary arteries result in high mortality. Receptor tyrosine kinases and their ligands, such as transforming growth factor (TGF)-α, modulate proliferation in PAH. Although the receptor tyrosine kinase c-Kit has been shown to be overexpressed in PAH, the expression and role of its ligand stem cell factor (SCF) remain unknown. However, low plasma SCF levels are known to be linked to higher cardiovascular mortality risk...
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30443556/limited-clinical-value-of-exhaled-volatile-organic-compound-measurements-in-childhood-asthma
#2
Maria G Fuglsbjerg, Morten A Rasmussen, Kirsten S Hansen, Agnieszka Smolinska, Jan W Dallinga, Frederik-Jan van Schooten, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Bo L Chawes
Exhaled volatile organic compound measurements do not aid the clinician diagnosing asthma in children http://ow.ly/Z2d930lpZ60.
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30443555/association-of-low-income-with-pulmonary-disease-progression-in-smokers-with-and-without-chronic-obstructive-pulmonary-disease
#3
Katherine E Lowe, Barry J Make, James D Crapo, Gregory L Kinney, John E Hokanson, Victor Kim, Anand S Iyer, Surya P Bhatt, Karin F Hoth, Kristen E Holm, Robert Wise, Dawn DeMeo, Marilyn G Foreman, Thomas J Stone, Elizabeth A Regan
Low socioeconomic status has been associated with chronic obstructive pulmonary disease (COPD) but little is known about its impact on disease progression. We assessed the association of income to symptoms, pulmonary disease severity and progression in smokers with and without COPD. The COPDGene cohort of 4826 smokers who reported annual income in phase 2 was analysed. Those who reported annual income <USD 15 000 per year were "low-income" and the remainder "higher income". Baseline demographics, symptoms, computed tomography (CT) imaging, and 5-year change in spirometry and CT metrics were characterised by group...
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30443554/circulating-desmosine-as-a-biomarker-of-azithromycin-treatment-response-a-post-hoc-analysis-of-the-columbus-randomised-controlled-trial
#4
James D Chalmers, Remco S Djamin, Marjolijn Schouten, Holly R Keir, Brendan Tan, Joachim G J V Aerts, Jeffrey T-J Huang, Menno van der Eerden
Circulating desmosine is not reduced by treatment with azithromycin in COPD but elevated desmosine may identify a patient group with a greater treatment response http://ow.ly/vN6N30mhBA1.
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30443553/expiratory-reactance-abnormalities-in-patients-with-expiratory-dynamic-airway-collapse-a-new-application-of-impulse-oscillometry
#5
David I Fielding, Justin Travers, Phan Nguyen, Michael G Brown, Gunter Hartel, Stephen Morrison
Expiratory dynamic airways collapse (EDAC) is a condition that affects the central airways; it is not well characterised physiologically, with relatively few studies. We sought to characterise impulse oscillometry (IOS) features of EDAC in patients with normal spirometry. Expiratory data were hypothesised to be the most revealing. In addition, we compared IOS findings in chronic obstructive pulmonary disease (COPD) patients with and without EDAC. EDAC was identified at bronchoscopy as 75-100% expiratory closure at the carina or bilateral main bronchi...
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30443552/the-impacts-of-cough-a-cross-sectional-study-in-a-finnish-adult-employee-population
#6
Heikki O Koskela, Anne M Lätti, Juha Pekkanen
Given the very high prevalence of cough, little is known about its impacts. A questionnaire was sent via e-mail to all public service employees in two towns in Finland. There were 373 subjects with acute cough, 174 with subacute cough and 421 with chronic cough. Cough-related quality of life was assessed with the Leicester Cough Questionnaire (LCQ) and depressive symptoms with Patient Health Questionnaire-2. In addition, data on doctor's visits and sick leave days were collected. Mean LCQ (95% CI) total scores were 16...
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30406126/asthma-severity-and-fertility-outcome-in-women-with-polycystic-ovary-syndrome-a-registry-based-study
#7
Louise Zierau, Rikke Cortes, Simon Francis Thomsen, Espen Jimenez-Solem, Svend Lindenberg, Vibeke Backer
Recent research suggests that women with polycystic ovary syndrome (PCOS) have a higher risk of asthma. However, the severity of asthma, use of antiasthma medication and effect on fertility have yet to be investigated. In a case-control cross-sectional registry study using the Danish National Patient Register and other Danish registries, asthma prevalence, asthma severity, antiasthma medication use and fertility outcome were investigated among two groups of women with PCOS (n=1358 and n=17 123) and a healthy control group (n=5340)...
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30406125/azithromycin-treatment-modifies-airway-and-blood-gene-expression-networks-in-neutrophilic-copd
#8
Katherine J Baines, Thomas K Wright, Peter G Gibson, Heather Powell, Philip M Hansbro, Jodie L Simpson
Long-term, low-dose azithromycin reduces exacerbation frequency in chronic obstructive pulmonary disease (COPD), yet the mechanism remains unclear. This study characterised genome-wide gene expression changes in patients with neutrophilic COPD following long-term, low-dose azithromycin treatment. Patients with neutrophilic COPD (>61% or >162×104 cells per mL sputum neutrophils) were randomised to receive either azithromycin or placebo for 12 weeks. Sputum and blood were obtained before and after 12 weeks of treatment...
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30406124/reflux-in-idiopathic-pulmonary-fibrosis-treatment-informed-by-an-integrated-approach
#9
Rhys Jones, Amaran Krishnan, Gemma L Zeybel, Emily Dookun, Jeffrey P Pearson, A John Simpson, S Michael Griffin, Chris Ward, Ian A Forrest
After MDT work-up and review, gastro-oesophageal reflux and pulmonary aspiration were found to be common in IPF patients; surgery was recommended in only 10% http://ow.ly/rO3T30lU17o.
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30406123/30-day-mortality-after-the-start-of-systemic-anticancer-therapy-for-lung-cancer-is-it-really-a-useful-performance-indicator
#10
Jacobus Adrianus Burgers, Ronald Alphons Damhuis
Systemic treatment is the standard treatment for unresectable stage III and IV lung cancer. Nevertheless, a 5-10% death rate has been described within 30 days after the last systemic treatment, suggesting that these patient did not benefit. We analysed the 30-day mortality after start of systemic therapy. Data were retrieved from the Netherlands National Cancer Registry. From 2010 to 2015, 26 277 patients were included. 56% were men. The median age was 65 years and 31% of patients were aged ≥70 years...
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30402452/survey-on-accessibility-and-real-life-application-of-noninvasive-ventilation
#11
Szymon Skoczyński, Raffaele Scala, Paolo Navalesi
Noninvasive mechanical ventilation (NIV) is an accepted method of respiratory failure treatment; however, at present, little is known about the global factors limiting NIV application. A survey designed to determine NIV accessibility and limiting factors in world economies and regions was developed. The questionnaire was sent to members of the European Respiratory Society (ERS) Respiratory Intensive Care Assembly and all ERS National Delegates. Replies to the survey were collected from 161 respondents from 46 countries...
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30402451/hospital-based-antibiotic-use-in-patients-with-mycobacterium-avium-complex
#12
Emily E Ricotta, Kenneth N Olivier, Yi Ling Lai, D Rebecca Prevots, Jennifer Adjemian
Treatment guidelines exist for pulmonary Mycobacterium avium complex (MAC) infection, although studies suggest poor concordance in clinician practice. Using a national database including hospital encounters of laboratory-confirmed MAC patients, we sought to characterise US treatment practices. We assessed patients in the Premier Healthcare Database from 2009 to 2013 with two or more MAC-positive cultures or one MAC-positive culture and the International Classification of Diseases (9th revision) code for pulmonary nontuberculous mycobacteria (PNTM)...
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30364407/long-term-safety-of-pirfenidone-results-of-the-prospective-observational-passport-study
#13
Vincent Cottin, Dirk Koschel, Andreas Günther, Carlo Albera, Arata Azuma, C Magnus Sköld, Sara Tomassetti, Philip Hormel, John L Stauffer, Indiana Strombom, Klaus-Uwe Kirchgaessler, Toby M Maher
Real-world studies include a broader patient population for a longer duration than randomised controlled trials (RCTs) and can provide relevant insights for clinical practice. PASSPORT was a multicentre, prospective, post-authorisation study of patients who were newly prescribed pirfenidone and followed for 2 years after initiating treatment. Physicians collected data on adverse drug reactions (ADRs), serious ADRs (SADRs) and ADRs of special interest (ADRSI) at baseline and then every 3 months. Post hoc stepwise logistic regression models were used to identify baseline characteristics associated with discontinuing treatment due to an ADR...
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30364376/impact-of-leaks-in-sulfur-hexafluoride-and-nitrogen-multiple-breath-washout-systems
#14
Jørgen G Nielsen
Sulfur hexafluoride multiple-breath washout is insensitive to inspiratory leaks http://ow.ly/Y3o830lKOpY.
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30364358/effect-of-intermittent-inspiratory-leaks-on-measurement-of-lung-clearance-index-using-nitrogen-and-sulfur-hexafluoride
#15
Florian Singer, Kathryn Ramsey, Philipp Latzin
Nitrogen MBW is susceptible to leaks; effects of leaks on sulfur hexafluoride MBW require further study http://ow.ly/iY6o30lGchV.
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30364344/effect-of-intermittent-inspiratory-leaks-on-measurement-of-lung-clearance-index-using-nitrogen-and-sulfur-hexafluoride
#16
Carl A Whitfield, Oliver E Jensen, Alex Horsley
Even small air leaks can have a significant impact on LCI measured using N2 . This is particularly the case for leaks that occur towards the end of washout. In contrast, leaks generally have a much smaller impact on LCI measured by SF6 . http://ow.ly/az7b30lG5Ku.
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30364342/safety-and-tolerability-of-nintedanib-for-the-treatment-of-idiopathic-pulmonary-fibrosis-in-routine-uk-clinical-practice
#17
Sophie V Fletcher, Mark G Jones, Elizabeth A Renzoni, Helen Parfrey, Rachel K Hoyles, Katherine Spinks, Maria Kokosi, Apollinaris Kwok, Chris Warburton, Vanessa Titmuss, Muhunthan Thillai, Nicola Simler, Toby M Maher, Christopher J Brereton, Felix Chua, Athol U Wells, Luca Richeldi, Lisa G Spencer
In IPF, commencement of antifibrotic therapy in patients with preserved lung volume may increase the duration of therapy http://ow.ly/4HeM30lFS67.
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30320130/increased-prevalence-of-expiratory-flow-limitation-during-exercise-in-children-with-bronchopulmonary-dysplasia
#18
Christopher A O'Dea, Karla Logie, Andrew Maiorana, Andrew C Wilson, J Jane Pillow, Georgia L Banton, Shannon J Simpson, Graham L Hall
Evidence regarding the prevalence of expiratory flow limitation (EFL) during exercise and the ventilatory response to exercise in children born preterm is limited. This study aimed to determine the prevalence of EFL as well as contributing factors to EFL and the ventilatory response to exercise in preterm children with and without bronchopulmonary dysplasia (BPD). Preterm children (≤32 weeks gestational age) aged 9-12 years with (n=64) and without (n=42) BPD and term controls (n=43), performed an incremental treadmill exercise test with exercise tidal flow-volume loops...
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30302335/preventing-clinically-important-deterioration-with-single-inhaler-triple-therapy-in-copd
#19
Ian Naya, Chris Compton, Afisi S Ismaila, Ruby Birk, Noushin Brealey, Maggie Tabberer, Chang-Qing Zhu, David A Lipson, Gerard Criner
Clinically important deterioration (CID) is a novel composite end-point (lung function, health status, exacerbations) for assessing disease stability in patients with chronic obstructive pulmonary disease (COPD). We prospectively analysed CID in the FULFIL study. FULFIL (ClinicalTrials.gov NCT02345161; randomised, double-blind, double-dummy, multicentre study) compared 24 weeks of once daily, single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25 µg with twice daily budesonide/formoterol (BUD/FOR) 400/12 μg in patients aged ≥40 years with symptomatic advanced COPD (Global Initiative for Chronic Obstructive Lung Disease group D)...
October 2018: ERJ Open Research
https://www.readbyqxmd.com/read/30302334/hypersensitivity-pneumonitis-in-fish-processing-workers-diagnosed-by-inhalation-challenge
#20
Gro Tjalvin, Øistein Svanes, Randi Jacobsen Bertelsen, Bjørg Eli Hollund, Tor B Aasen, Cecilie Svanes, Jorunn Kirkeleit
Hypersensitivity pneumonitis may be caused by occupational exposure in the fish processing industry http://ow.ly/GbEf30lFnyk.
October 2018: ERJ Open Research
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