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ERJ Open Research

Pinelopi Anagnostopoulou, Nadja Kranz, Jeremias Wolfensberger, Marisa Guidi, Sylvia Nyilas, Cordula Koerner-Rettberg, Sophie Yammine, Florian Singer, Philipp Latzin
Lung clearance index (LCI) is the main outcome of the multiple-breath washout (MBW) test. Current recommendations for LCI acquisition are based on low-grade evidence. The aim of this study was to challenge those recommendations using alternative methods for LCI analysis. Nitrogen MBW measurements from school-aged children, 20 healthy controls, 20 with cystic fibrosis (CF) and 17 with primary ciliary dyskinesia (PCD), were analysed using 1) current algorithms (standard), 2) three alternative algorithms to detect with higher precision the end of MBW testing and 3) two alternative algorithms to determine exhaled tracer gas concentrations...
July 2018: ERJ Open Research
Nishta Kaushik, Chris Lowbridge, Gabriella Scandurra, Claudia C Dobler
Following pre-migration screening for tuberculosis (TB), migrants who are deemed to be at a high risk of developing TB must attend post-entry follow-up in Australia. We aimed to evaluate the effectiveness of post-migration TB follow-up in the state of New South Wales to diagnose TB in these high-risk migrants. In this retrospective cohort study, we assessed the risk of TB in migrants who arrived in New South Wales between 2000 and 2015 and were referred for post-migration follow-up. Clinical notes were examined for a nested cohort to determine whether TB was diagnosed via the follow-up programme or via passive case finding...
July 2018: ERJ Open Research
Moana Mika, Izabela Nita, Laura Morf, Weihong Qi, Seraina Beyeler, Eric Bernasconi, Benjamin J Marsland, Sebastian R Ott, Christophe von Garnier, Markus Hilty
Compartmentalisation of the respiratory tract microbiota in patients with different chronic obstructive pulmonary disease (COPD) severity degrees needs to be systematically investigated. In addition, it is unknown if the inflammatory and emphysematous milieux in patients with COPD are associated with changes in the respiratory tract microbiota and host macrophage gene expression. We performed a cross-sectional study to compare non-COPD controls (n=10) to COPD patients (n=32) with different disease severity degrees...
July 2018: ERJ Open Research
Kozo Morimoto, Akio Aono, Yoshiro Murase, Tsuyoshi Sekizuka, Atsuyuki Kurashima, Akiko Takaki, Yuka Sasaki, Yuriko Igarashi, Kinuyo Chikamatsu, Hajime Goto, Hiroyuki Yamada, Makoto Kuroda, Satoshi Mitarai
Reinfection of nontuberculous mycobacterium pulmonary disease may be caused by identical and not different genotypes
July 2018: ERJ Open Research
Frantzeska Frantzeskaki, Stylianos E Orfanos
A detailed and comprehensive summary of the ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia, published in ERJ Open Research , will assist clinicians in their tasks
April 2018: ERJ Open Research
Soumya Bhattacharjee, Prasun Haldar, Santi Gopal Maity, Smriti Debnath, Saibal Moitra, Sujoy Saha, Ritabrata Mitra, Isabella Annesi-Maesano, Judith Garcia-Aymerich, Subhabrata Moitra
Despite a considerable number of international reports on allergic diseases among children, information about the prevalence and risk factors of asthma and allergy-related diseases among Indian adolescents is relatively sparse. The Prevalence and Risk Factors of Asthma and Allergy-Related Diseases among Adolescents (PERFORMANCE) study has been conceived to study the aetiology of asthma and allergic diseases including rhinoconjunctivitis, atopic eczema and food allergies among adolescents in West Bengal, India, using standardised methods and collaborations...
April 2018: ERJ Open Research
Jessica L Tsui, Oscar A Estrada, Zimu Deng, Kristin M Wang, Christopher S Law, Brett M Elicker, Kirk D Jones, Sharon D Dell, Gunnar Gudmundsson, Sif Hansdottir, Simon M Helfgott, Stefano Volpi, Marco Gattorno, Michael R Waterfield, Alice Y Chan, Sharon A Chung, Brett Ley, Anthony K Shum
The COPA syndrome is a monogenic, autoimmune lung and joint disorder first identified in 2015. This study sought to define the main pulmonary features of the COPA syndrome in an international cohort of patients, analyse patient responses to treatment and highlight when genetic testing should be considered. We established a cohort of subjects (N=14) with COPA syndrome seen at multiple centres including the University of California, San Francisco, CA, USA. All subjects had one of the previously established mutations in the COPA gene, and had clinically apparent lung disease and arthritis...
April 2018: ERJ Open Research
Tore Tynes, Eva Kristin Løvseth, Håkon A Johannessen, Tom Sterud, Marit Skogstad
Dust at work is associated with risk of respiratory symptoms, the population attributable fraction is 19, and smoking is an effect modifier
April 2018: ERJ Open Research
Antoni Torres, Michael S Niederman, Jean Chastre, Santiago Ewig, Patricia Fernandez-Vandellos, Hakan Hanberger, Marin Kollef, Gianluigi Li Bassi, Carlos M Luna, Ignacio Martin-Loeches, J Artur Paiva, Robert C Read, David Rigau, Jean François Timsit, Tobias Welte, Richard Wunderink
A summary of the evidence and recommendations made in the ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia
April 2018: ERJ Open Research
Taylor E Woo, Rachel Lim, Michael G Surette, Barbara Waddell, Joel C Bowron, Ranjani Somayaji, Jessica Duong, Christopher H Mody, Harvey R Rabin, Douglas G Storey, Michael D Parkins
The natural history and epidemiology of Pseudomonas aeruginosa infections in non-cystic fibrosis (non-CF) bronchiectasis is not well understood. As such it was our intention to determine the evolution of airway infection and the transmission potential of P. aeruginosa in patients with non-CF bronchiectasis. A longitudinal cohort study was conducted from 1986-2011 using a biobank of prospectively collected isolates from patients with non-CF bronchiectasis. Patients included were ≥18 years old and had ≥2 positive P...
April 2018: ERJ Open Research
Walter Vincken, Mark L Levy, Jane Scullion, Omar S Usmani, P N Richard Dekhuijzen, Chris J Corrigan
We present an extensive review of the literature to date pertaining to the rationale for using a spacer/valved holding chamber (VHC) to deliver inhaled therapy from a pressurised, metered-dose inhaler, a discussion of how the properties of individual devices may vary according to their physical characteristics and materials of manufacture, the potential risks and benefits of ancillaries such as valves, and the evidence that they contribute tangibly to the delivery of therapy. We also reiterate practical recommendations for the correct usage and maintenance of spacers/VHCs, which we trust offer practical help and advice to patients and healthcare professionals alike...
April 2018: ERJ Open Research
Rachid Tazi-Mezalek, Diane Frankel, Marc Fortin, Elise Kaspi, Julien Guinde, Alexandra Assolen, Sophie Laroumagne, Andree Robaglia, Herve Dutau, Patrice Roll, Philippe Astoul
Talc pleurodesis is used to avoid recurrences in malignant pleural effusions or pneumothorax. The lack of lung sliding detected by chest ultrasonography (CUS) after talc application is indicative of the effectiveness of pleurodesis. The objective of our study was to explore, in an animal model, the capacity of CUS to predict the quality of a symphysis induced by talc poudrage (TP) and talc slurry (TS). We induced an artificial pneumothorax in six healthy pigs prior to talc application. TP was performed on one hemithorax, followed by TS on the other side 1 week later...
April 2018: ERJ Open Research
Geertje M de Boer, T H Mennema, Esther van Noort, Niels H Chavannes, Erwin Birnie, Johannes C C M In 't Veen
Personal traits should be addressed before offering self-management programmes to patients with COPD
April 2018: ERJ Open Research
Pentti Nieminen, Tuula Toljamo, Hannu Vähänikkilä
Data analysis methods play an important role in respiratory research. We evaluated the application and complexity of data analytical methods in high-impact respiratory journals and compared the statistical reporting in these respiratory articles with reports published in other eminent medical journals. This study involved a total of 160 papers published in 2015 in the European Respiratory Journal, American Journal of Respiratory and Critical Care Medicine, Chest and Thorax , and 680 papers published between 2007-2015 in other medical journals including the Lancet and New England Journal of Medicine ...
April 2018: ERJ Open Research
Benoit Wallaert, Nicolas Masson, Olivier Le Rouzic, Baptiste Chéhère, Lidwine Wémeau-Stervinou, Jean-Marie Grosbois
Fibrotic idiopathic interstitial pneumonia patients derived benefit from a pulmonary rehabilitation programme in terms of exercise tolerance, anxiety, depression and quality of life without increasing their daily life physical activity
April 2018: ERJ Open Research
Jonathan Grigg, Jürg Barben, Mark L Everard, Graham Hall, Bülent Karadag, Alexander Moeller, Raffaella Nenna, Kostas N Priftis, Robbert J Rottier, Suzanne W J Terheggen-Lagro, Fabio Midulla
In this article, the group chairs of the Paediatric Assembly of the European Respiratory Society (ERS) highlight some of the most interesting findings presented at the 2017 ERS International Congress, which was held in Milan, Italy.
April 2018: ERJ Open Research
Ole Hilberg, Elisabeth Bendstrup, Rikke Ibsen, Anders Løkke, Charlotte Hyldgaard
When a patient is diagnosed with IPF, the net health costs increase from €2753 to €21 184 per year even without the cost of antifibrotic treatment. Inpatient treatment accounts for the main part of the expenses
April 2018: ERJ Open Research
Alida Benfante, Fabiano Di Marco, Silvia Terraneo, Stefano Centanni, Nicola Scichilone
We tested the hypothesis that dynamic hyperinflation develops in severe asthmatic subjects during exercise. Changes in inspiratory capacity (IC) were measured during the 6-min walk test (6MWT) in severe asthmatic subjects compared with chronic obstructive pulmonary disease (COPD) subjects with a similar degree of bronchial obstruction. We assessed whether changes in IC were associated with changes in dyspnoea perception. 27 severe asthmatic subjects (10 males and 17 females) and 43 COPD subjects (35 males and eight females) were recruited...
April 2018: ERJ Open Research
Nina Elisabeth Hjorth, Dagny Faksvåg Haugen, Margrethe Aase Schaufel
Advance care planning (ACP) is a communication process for mapping a patient's wishes and priorities for end-of-life care. In preparation for the introduction of ACP in Norway, we wanted to explore the views of Norwegian pulmonary patients on ACP. We conducted four focus group interviews in a Norwegian teaching hospital, with a sample of 13 patients suffering from chronic obstructive pulmonary disease, lung cancer or lung fibrosis. Analysis was by systematic text condensation. Participants' primary need facing end-of-life communication was "the comforting safety", implying support, information and transparency, with four underlying themes: 1) provide good team players; 2) offer conversations with basic information; 3) seize the turning point; and 4) balance transparency...
April 2018: ERJ Open Research
Christopher C Butler, Samuel Coenen, Benjamin R Saville, Johanna Cook, Alike van der Velden, Jane Homes, Menno de Jong, Paul Little, Herman Goossens, Philippe Beutels, Margareta Ieven, Nick Francis, Pieter Moons, Emily Bongard, Theo Verheij
ALIC4 E is the first publicly funded, multicountry, pragmatic study determining whether antivirals should be routinely prescribed for influenza-like illness in primary care. The trial aims to go beyond determining the average treatment effect in a population to determining effects in patients with combinations of participant characteristics (age, symptom duration, illness severity, and comorbidities). It is one of the first platform, response-adaptive, open trial designs implemented in primary care, and this article aims to provide an accessible description of key aspects of the study design...
April 2018: ERJ Open Research
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