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Gastrointestinal Tumors

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https://www.readbyqxmd.com/read/28611983/accuracy-of-multidetector-row-computed-tomography-in-the-preoperative-diagnosis-of-lymph-node-metastasis-in-patients-with-gastric-cancer
#1
Keisuke Kubota, Akihiro Suzuki, Hironori Shiozaki, Takeshi Wada, Tomoki Kyosaka, Akihiro Kishida
BACKGROUND/AIMS: Preoperative lymph node staging in gastric cancer patients is important. The aim of this study was to assess the diagnostic accuracy of computed tomography (CT) in assessing lymph nodes in patients with gastric cancer. METHODS: A total of 56 patients had undergone standardized gastric resection with lymphadenectomy between October 2013 and June 2015 were reviewed retrospectively. The short axis diameter of the largest lymph node per station was recorded when reviewing the preoperative CT images...
March 2017: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/28611982/enucleation-versus-anatomic-resection-for-giant-hepatic-hemangioma-a-meta-analysis
#2
Yuhui Liu, Xuyong Wei, Kun Wang, Qiaonan Shan, Haojiang Dai, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng
BACKGROUND: Hepatic hemangiomas are the most common benign liver tumors, and the management of giant hepatic hemangioma (GHH) is still in controversial. The aim of this meta-analysis was to compare the postoperative outcomes of enucleation versus anatomic resection for GHH. METHODS: PubMed, Embase, Web of Science, and the Cochrane Library were searched from January 1988 to December 2015 to identify studies comparing the outcomes of enucleation versus anatomic resection for GHH...
March 2017: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/28611981/the-clinical-significance-of-alpha-fetoprotein-mrnas-in-patients-with-hepatocellular-carcinoma
#3
Shogo Kobayashi, Akira Tomokuni, Hidenori Takahashi, Hirofumi Akita, Keijiro Sugimura, Norikatsu Miyoshi, Jeong Ho Moon, Masayoshi Yasui, Takeshi Omori, Masayuki Ohue, Yoshiyuki Fujiwara, Masahiko Yano, Masato Sakon
BACKGROUND/AIMS: Alpha-fetoprotein (AFP) mRNA-expressing cells are candidates for circulating tumor cells in hepatocellular carcinoma. We analyzed portal vein blood, peripheral blood, and peritoneal lavage samples to detect the presence of AFP mRNA-expressing cells, and explored their relationship with metastasis. METHODS: We measured the AFP mRNA expression in 112 sets of portal vein and peripheral blood samples and 61 peritoneal lavage samples that had been obtained during surgery...
March 2017: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/28611980/there-is-no-role-for-colonoscopy-after-diverticulitis-among-asian-patients-less-than-50-years-of-age
#4
Dedrick Kok Hong Chan, Ker-Kan Tan
BACKGROUND: Colonoscopy is advocated following acute diverticulitis to ensure that malignancy is not missed. In an Asian population, diverticulitis is more common in the right colon and in younger patients. The purpose of this study is to examine the utility of colonoscopy amongst Asian patients <50 years of age who have had colonic diverticulitis. METHODS: A retrospective review of all patients aged 50 years and under who were treated for colonic diverticulitis between 2012 and 2014 was performed...
March 2017: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/28611979/impact-of-preferentially-expressed-antigen-of-melanoma-on-the-prognosis-of-hepatocellular-carcinoma
#5
Kenji Oyama, Keita Kanki, Hiroki Shimizu, Yohei Kono, Junya Azumi, Kan Toriguchi, Etsuro Hatano, Goshi Shiota
BACKGROUND: Retinoids, vitamin A and its derivatives, have an antitumor effect on hepatocellular carcinoma (HCC). The function of retinoids is exerted by the complex of retinoic acid (RA) with the heterodimer of retinoid X receptor and the RA receptor. The preferentially expressed antigen of melanoma (PRAME) acts as a dominant repressor of RA signaling by binding to the complex. The significance of PRAME on the prognosis of HCC remains to be clarified. METHODS: PRAME mRNA expression was examined by quantitative real-time polymerase chain reaction in both tumor and non-tumor tissues of 100 HCC patients who received surgical resection...
March 2017: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/28611978/periodontal-pathogens-in-the-etiology-of-pancreatic-cancer
#6
REVIEW
Mesut Öğrendik
BACKGROUND: Pancreatic cancer is the fourth leading cause of cancer-related deaths worldwide. Chronic pancreatitis is frequently observed in patients with pancreatic cancer, and a significant relationship between orodigestive cancer-related deaths and chronic periodontitis has been detected. Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, collectively called the Red complex, are the major pathogens responsible for chronic periodontitis and secrete peptidylarginine deiminase...
March 2017: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/28611977/clinicopathology-of-early-gastric-carcinoma-an-update-for-pathologists-and-gastroenterologists
#7
REVIEW
Qin Huang, Xiaoping Zou
BACKGROUND: The WHO defines early gastric carcinoma (EGC) as invasive carcinoma up to the submucosal layer, regardless of nodal metastasis. The recent study results indicate that EGC varies in location, histology, nodal metastasis, and prognosis. SUMMARY: The heterogeneity in EGC may be related to various types of epithelial stem cells. The most important stem cells include Lgr5(+) cells at the base of a gastric unit in the antrum-pylorus-cardia, Mist1(+) cells at the isthmus/Troy(+) cells at the base in the corpus-fundus, and Sox2(+) cells at the base in almost all regions...
March 2017: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27904863/recent-updates-in-the-endoscopic-diagnosis-of-barrett-s-oesophagus
#8
REVIEW
Neel Sharma, Khek Yu Ho
BACKGROUND: Barrett's oesophagus (BO) is a premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Despite the low risk of progression per annum, OAC is associated with significant morbidity and mortality, with an estimated 5-year survival of 10%. Furthermore, the incidence of OAC continues to rise globally. Therefore, it is imperative to detect the premalignant phase of BO and follow up such patients accordingly. SUMMARY: The mainstay diagnosis of BO is endoscopy and biopsy sampling...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27904862/risk-factors-for-barrett-s-oesophagus
#9
REVIEW
Neel Sharma, Khek Yu Ho
BACKGROUND: Barrett's oesophagus (BO) is a premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Globally, the incidence of OAC is rising. Furthermore, the prognosis regarding the morbidity and mortality of OAC is bleak, with an estimated 5-year survival of 10-15%. Hence, detection of the premalignant phase is paramount. Endoscopy and biopsy sampling is the mainstay of diagnosis. Patients may present with symptoms of gastro-oesophageal reflux disease (GORD) or be completely asymptomatic...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27904861/a-recent-advance-in-image-guided-locoregional-therapy-for-hepatocellular-carcinoma
#10
REVIEW
Yaoping Shi, Bo Zhai
BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most common cause of cancer-related deaths. Hepatic resection and liver transplantation are considered to be the preferred treatment for HCC. However, as novel therapeutic options such as image-guided locoregional therapies have emerged and been refined, the manner in which HCC is treated has changed dramatically compared with what it was considered just 2 decades earlier. SUMMARY: This study reviews the current results of various image-guided locoregional therapies for treating HCC, especially focusing on thermal ablative and transarterial techniques...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27904860/interventional-therapy-for-pancreatic-cancer
#11
REVIEW
Jianwei Zhu, Zhendong Jin
BACKGROUND: Palliative therapy and primarily chemoradiotherapy are the mainstream treatments in patients with locally advanced or metastatic pancreatic cancer (PC). Conventional endoscopy and endoscopic ultrasound (EUS)-guided interventional therapy has emerged as an important procedure for PC management. In this review, the progress in conventional endoscopy and EUS for PC management is discussed. SUMMARY: For local palliative therapy against PC, EUS-guided fine needle injection (FNI) could deliver different kinds of agents, such as radioactive seeds and fiducials...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27904859/endoscopic-approach-for-superficial-colorectal-neoplasms
#12
REVIEW
Jun-Feng Xu, Lang Yang, Peng Jin, Jian-Qiu Sheng
BACKGROUND: Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females, with an estimated 1.4 million cases and 693,900 deaths in 2012. Colonoscopy is the cornerstone for the detection and prevention of CRC. In addition, endoscopic treatment for CRC at an early stage can effectively improve patients' quality of life and cure rate. SUMMARY: This review focuses on endoscopic approaches, including white light endoscopy, chromoendoscopy, magnifying endoscopy and therapeutic endoscopy, for the evaluation and treatment of superficial colorectal neoplasms...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27904858/interventional-therapy-of-esophageal-cancer
#13
REVIEW
Aiwu Mao
Esophageal cancer (EC) is the fourth leading cause of cancer death in China. Despite a lot of advances in diagnosis and therapy, the survival rate of patients with EC is low. There is urgent need for a variety of methods and techniques to improve the survival time and alleviate the lesions of EC. Nowadays, alternative and less invasive approaches to the treatment of ECs are being identified. Here, we review several main interventional methods at different stages of EC, including endoscopic resection, stent placement, arterial infusion, photodynamic therapy, and radiofrequency ablation...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27722156/evaluation-of-inos-expression-in-esophageal-cancer-patients
#14
Romina Barani, Gholamreza Motalleb, Hossein Maghsoudi
BACKGROUND: Esophageal cancer is a public health concern around the world; this cancer is the sixth leading cause of death of cancer in the world with about 386,000 deaths per year. Its risk factors include environmental factors such as tobacco smoke, gastroesophageal reflux and genetic changes. iNOS is stated by the effect of various inflammatory factors and is thus called inducible NOS. Investigating iNOS expression is a powerful tool for understanding effective molecular parameters at tissue and cellular responses to external factors...
September 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27722155/prevention-of-hepatocellular-carcinoma
#15
REVIEW
Kerstin Schütte, Fathi Balbisi, Peter Malfertheiner
The epidemiology of hepatocellular carcinoma (HCC) has significantly changed throughout the past decade and will continue to do so in the future as a consequence of effective primary prevention and treatment of virus-related liver diseases. However, other risk factors for HCC are constantly on the rise, including alcoholic liver disease and nonalcoholic fatty liver disease. The knowledge on these and further risk factors associated with an increased risk of HCC provide the opportunity and chance for the development and implementation of successful preventive strategies to decrease the worldwide burden of HCC...
September 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27722154/etiology-and-prevention-of-gastric-cancer
#16
REVIEW
Xiao Jiao Cheng, Jia Cheng Lin, Shui Ping Tu
BACKGROUND: Gastric cancer is a heterogeneous malignant disease associated with environmental and genetic predisposing factors. While gastric cancer incidence and mortality fell greatly globally over the past decades, it remains the fourth cause of cancer-related death worldwide. Thus, prevention of gastric cancer is still a major strategy for improvement of gastric cancer prognosis. SUMMARY: Helicobacter pylori infection has been demonstrated to be a major risk factor for the development of gastric cancer...
September 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27722153/dietary-and-lifestyle-factors-associated-with-colorectal-cancer-risk-and-interactions-with-microbiota-fiber-red-or-processed-meat-and-alcoholic-drinks
#17
Juan Tuan, Ying-Xuan Chen
BACKGROUND: Diets and lifestyles have been strongly associated with colorectal cancer (CRC). In the past several decades, emerging evidence has suggested that the gut microbiota may have a role in the development of CRC. Its interaction with diets and lifestyles could affect the carcinogenesis of CRC. SUMMARY: This review presents the most recent epidemiologic and experimental evidence of three factors that may convincingly have a role in CRC, including fiber, red or processed meat, and alcohol, focusing on potential mechanisms and their interactions with the gut microbiota...
September 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27722152/etiology-and-prevention-of-esophageal-cancer
#18
Chung S Yang, Xiaoxin Chen, Shuiping Tu
BACKGROUND: Esophageal cancer (EC) occurs commonly, especially in Asia, and is the sixth leading cause of cancer deaths worldwide. Recently, great progress has been made in research on the etiology and prevention of EC. SUMMARY: The major risk factors for esophageal squamous cell carcinoma (ESCC) are tobacco smoking and alcohol drinking, which act synergistically. Dietary parameters, including dietary carcinogens and insufficiency of micronutrients, could also be important risk factors in certain areas...
September 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27722151/general-and-specific-prevention-strategies-for-gastrointestinal-cancers
#19
Peter Malfertheiner
No abstract text is available yet for this article.
September 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27403415/nutrients-impact-the-pathogenesis-and-development-of-colorectal-cancer
#20
REVIEW
Wan Du, Jing-Yuan Fang
BACKGROUND: Colorectal cancer is a commonly diagnosed cancer and the cause of many cancer deaths worldwide. Nutrients might be crucial in the pathogenesis and development of colorectal cancer. Although a number of studies have demonstrated the potential effects of nutrients, many challenges still remain. SUMMARY: A tremendous amount of research has emerged concerning the roles of nutrients in colorectal cancer during the past decades. Here, we review the latest research progress on nutrients, including vitamins, folic acid, calcium, selenium and dietary fiber, involved in colorectal cancer prevention...
May 2016: Gastrointestinal Tumors
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