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Journals Frontiers in Cardiovascular Me...

Frontiers in Cardiovascular Medicine

https://read.qxmd.com/read/38545348/case-report-heart-aneurysm-of-unknown-origin-in-a-two-year-old-child-diagnosed-in-the-course-of-multisystem-inflammatory-syndrome-in-children
#1
Dominika Mystkowska, Michal Galeczka, Wojciech Tarala, Pawel Banaszak, Joanna Sliwka, Szymon Pawlak, Roland Fiszer
We present a case of a 22-month-old boy with a hypokinetic and thin-walled aneurysm of the left ventricle apex. The lesion was diagnosed during routine echocardiography examination in the course of MIS-C, and its occurrence due to MIS-C is plausible. Cardiac magnetic resonance imaging revealed an akinetic aneurysm of the LV apex with a full-wall ischemic scar. Aortography confirmed a normal course of coronary arteries, with adequate perfusion of essential branches and no evidence of stenosis or aneurysms. The boy underwent consultation with the heart team and was deemed eligible for surgery...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38545347/construction-of-a-nomogram-risk-prediction-model-for-prolonged-mechanical-ventilation-in-patients-following-surgery-for-acute-type-a-aortic-dissection
#2
JOURNAL ARTICLE
Yun Yu, Yan Wang, Fang Deng, Zhigang Wang, Beibei Shen, Ping Zhang, Zheyun Wang, Yunyan Su
BACKGROUND: This study aims to analyze the risk factors associated with prolonged mechanical ventilation (PMV) in patients following surgical treatment for acute type A aortic dissection (ATAAD). The objectives include constructing a predictive model for risk assessment and validating its predictive efficacy. METHODS: A total of 452 patients diagnosed with ATAAD and undergoing surgical procedures at a tertiary hospital in Nanjing between January 2021 and April 2023 were selected using a convenience sampling method...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38545346/contemporary-approach-to-cardiogenic-shock-care-a-state-of-the-art-review
#3
REVIEW
Aditya Mehta, Ilan Vavilin, Andrew H Nguyen, Wayne B Batchelor, Vanessa Blumer, Lindsey Cilia, Aditya Dewanjee, Mehul Desai, Shashank S Desai, Michael C Flanagan, Iyad N Isseh, Jamie L W Kennedy, Katherine M Klein, Hala Moukhachen, Mitchell A Psotka, Anika Raja, Carolyn M Rosner, Palak Shah, Daniel G Tang, Alexander G Truesdell, Behnam N Tehrani, Shashank S Sinha
Cardiogenic shock (CS) is a time-sensitive and hemodynamically complex syndrome with a broad spectrum of etiologies and clinical presentations. Despite contemporary therapies, CS continues to maintain high morbidity and mortality ranging from 35 to 50%. More recently, burgeoning observational research in this field aimed at enhancing the early recognition and characterization of the shock state through standardized team-based protocols, comprehensive hemodynamic profiling, and tailored and selective utilization of temporary mechanical circulatory support devices has been associated with improved outcomes...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38545345/lipoprotein-a-as-a-risk-factor-for-atherosclerotic-cardiovascular-disease-in-patients-in-non-metropolitan-areas-of-brandenburg-germany
#4
JOURNAL ARTICLE
Philipp Hillmeister, Kangbo Li, Mengjun Dai, Mesud Sacirovic, Nikolaos Pagonas, Oliver Ritter, Peter Bramlage, Anja Bondke Persson, Ivo Buschmann, Claudia Zemmrich
BACKGROUND AND AIMS: In the non-metropolitan region of Brandenburg (Germany), which is characterized by high rates of cardiovascular diseases and underserved medical care, there is a lack of awareness regarding lipoprotein(a) [Lp(a)] as a risk factor. In addition, data from patients with atherosclerotic cardiovascular disease (ASCVD) in diverse regional backgrounds, including the understudied Brandenburg cohort, and various healthcare statuses remain insufficient. METHODS: In this WalkByLab study, Lp(a) levels were monitored in a non-metropolitan cohort ( n  = 850) in Brandenburg, Germany, comprising 533 patients at high cardiovascular risk and 317 healthy controls...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38545344/effect-of-statin-add-on-therapy-on-cardiovascular-mortality
#5
REVIEW
John R Nelson, Viet Le, Jeffrey L Anderson, Nicole Ciffone
INTRODUCTION: Cardiovascular (CV) disease remains a leading cause of mortality despite statin therapy. Statin add-on lipid-lowering therapies have been investigated for CV risk reduction, but their effect on CV mortality has not been reviewed. METHODS: This review describes CV outcomes trials of add-on therapies to statins, highlighting findings related to the primary composite CV endpoints and the more patient-centric endpoint of CV-related mortality. RESULTS: Add-on ezetimibe met its primary composite CV endpoint vs...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38545343/risk-factors-prevention-and-therapy-of-intraluminal-stent-thrombosis-in-frozen-elephant-trunk-prostheses-what-we-know-so-far
#6
REVIEW
Florian Helms, Bastian Schmack, Alexander Weymann, Reza Poyanmehr, Andreas Martens, Jawad Salman, Alina Zubarevich, Jan D Schmitto, Arjang Ruhparwar, Aron-Frederik Popov
Intraluminal thrombus formation (ILT) is a recently discovered and highly clinically relevant complication after frozen elephant trunk implantation in cardiovascular surgery. In this phenomenon, a thrombus forms within the lumen of the stent graft component of the frozen elephant trunk prosthesis and puts the patient at risk for downstream embolization with visceral or lower limb ischemia. Incidence of ILT reported in the currently available studies ranges from 6% to 17% of patients after frozen elephant trunk implantation...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38545342/the-impact-of-endovascular-stents-types-on-perioperative-outcomes-of-ruptured-abdominal-aortic-aneurysms-a-single-center-experience
#7
JOURNAL ARTICLE
Huibo Ma, Xueyi Wang, Yangshuo Liu, Yongxin Li, Mingjin Guo
INTRODUCTION: Ruptured abdominal aortic aneurysm (rAAA) represents a critically urgent vascular surgical condition, and endovascular aneurysm repair (EVAR) is a clinically effective treatment option. This study aims to investigate whether the type of intravascular graft used for ruptured abdominal aortic aneurysms has an impact on perioperative outcomes of EVAR. METHODS: A retrospective analysis was conducted on patients who underwent EVAR for ruptured abdominal aortic aneurysm at a single medical center from 2019 to 2022...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38545341/role-and-mechanism-of-mirna-in-cardiac-microvascular-endothelial-cells-in-cardiovascular-diseases
#8
REVIEW
Junyuan Yan, Xinqin Zhong, Yucui Zhao, Xiaoying Wang
The occurrence and development of myocardial dysfunction are associated with damage in the cardiac microvascular endothelial cells (CMECs), which can regulate nutrient exchange and oxy-gen-carbon cycling to protect cardiomyocytes. Interventions targeting microRNAs (miRNAs) can effectively mitigate CMEC injury and thus improve cardiovascular diseases. MiRNAs are a class of noncoding single-strand RNA molecules typically 21-23 nucleotides in length that are encoded by endogenous genes. They are critical regulators of organism development, cell differentiation, metabolism, and apoptosis...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38545340/healthcare-needs-in-elderly-patients-with-chronic-heart-failure-in-view-of-a-personalized-blended-collaborative-care-intervention-a-cross-sectional-study
#9
JOURNAL ARTICLE
Sara Gostoli, Francesco Bernardini, Regina Subach, Petra Engelmann, Tiny Jaarsma, Frida Andréasson, Sanne Rasmussen, Trine Thilsing, Natasja Eilerskov, Barbara Bordoni, Diego Della Riva, Stefano Urbinati, Sebastian Kohlmann, Chiara Rafanelli
INTRODUCTION: Few studies explored healthcare needs of elderly heart failure (HF) patients with comorbidities in view of a personalized intervention conducted by Care Managers (CM) in the framework of Blended Collaborative Care (BCC). The aims of the present study were to: (1) identify perceived healthcare needs/preferences in elderly patients with HF prior to a CM intervention; (2) investigate possible associations between healthcare needs/preferences, sociodemographic variables (age; sex) and number of comorbidities...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38545339/the-fbn1-gene-variant-governs-passive-ascending-aortic-mechanics-in-the-mg%C3%AE-lpn-mouse-model-of-marfan-syndrome-when-superimposed-to-perlecan-haploinsufficiency
#10
JOURNAL ARTICLE
Samar A Tarraf, Rodrigo Barbosa de Souza, Ashley Herrick, Lygia V Pereira, Chiara Bellini
INTRODUCTION: Ascending thoracic aortic aneurysms arise from pathological tissue remodeling that leads to abnormal wall dilation and increases the risk of fatal dissection/rupture. Large variability in disease manifestations across family members who carry a causative genetic variant for thoracic aortic aneurysms suggests that genetic modifiers may exacerbate clinical outcomes. Decreased perlecan expression in the aorta of mgΔ l p n mice with severe Marfan syndrome phenotype advocates for exploring perlecan-encoding Hspg2 as a candidate modifier gene...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38545338/insulin-resistance-hyperinsulinemia-an-important-cardiovascular-risk-factor-that-has-long-been-underestimated
#11
JOURNAL ARTICLE
Serafino Fazio, Valentina Mercurio, Loredana Tibullo, Valeria Fazio, Flora Affuso
Cardiovascular mortality is still excessively high, despite the considerable progress made in the prevention and treatment of cardiovascular diseases. Although many cardiovascular risk factors (such as arterial hypertension, hypercholesterolemia, diabetes, etc.), identified in the general population, are being promptly treated, to date little consideration is given to a cardiovascular risk factor which we believe has largely demonstrated in the scientific literature of the last three decades that, if neglected, can produce a series of relevant negative effects on the cardiovascular system: insulin resistance (IR)/hyperinsulinemia (Hyperins)...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38532873/case-report-neurological-adverse-events-in-subject-with-myasthenia-gravis-after-pcsk9-inhibitor-administration
#12
Věra Adámková, Martina Vitásková, Jaroslav A Hubáček
BACKGROUND: Myasthenia gravis is a rare chronic autoimmune neuromuscular disorder mainly caused by autoantibodies to the nicotinic acetylcholine receptor. Cholesterol is an essential molecule that affects the distribution and proper functioning of this receptor. Several reports have described the potential worsening of myasthenia gravis in patients treated with statins. CASE PRESENTATION: The patient was an obese 72 years old man, past smoker, diagnosed with ischaemic heart disease, type 2 diabetes mellitus and lipid metabolism disorder...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38529334/stress-hyperglycemia-and-poor-outcomes-in-patients-with-st-elevation-myocardial-infarction-a-systematic-review-and-meta-analysis
#13
Abdul Hakim Alkatiri, Nurul Qalby, Idar Mappangara, Ahmad Taufik F Zainal, Maarten J Cramer, Pieter A Doevendans, Andriany Qanitha
BACKGROUND: Hyperglycemia, characterized by elevated blood glucose levels, is frequently observed in patients with acute coronary syndrome, including ST-elevation myocardial infarction (STEMI). There are conflicting sources regarding the relationship between hyperglycemia and outcomes in STEMI patients. We aimed to compile evidence to assess the association between hyperglycemia and adverse outcomes. METHODS: We conducted a comprehensive search for articles on PubMed and Embase using search strategies which yielded 4,061 articles...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38529333/gender-specific-genetic-and-epigenetic-signatures-in-cardiovascular-disease
#14
REVIEW
Justin Bridges, Jose A Ramirez-Guerrero, Manuel Rosa-Garrido
Cardiac sex differences represent a pertinent focus in pursuit of the long-awaited goal of personalized medicine. Despite evident disparities in the onset and progression of cardiac pathology between sexes, historical oversight has led to the neglect of gender-specific considerations in the treatment of patients. This oversight is attributed to a predominant focus on male samples and a lack of sex-based segregation in patient studies. Recognizing these sex differences is not only relevant to the treatment of cisgender individuals; it also holds paramount importance in addressing the healthcare needs of transgender patients, a demographic that is increasingly prominent in contemporary society...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38529332/estimation-of-aortic-stiffness-by-finger-photoplethysmography-using-enhanced-pulse-wave-analysis-and-machine-learning
#15
JOURNAL ARTICLE
Henrik Hellqvist, Mikael Karlsson, Johan Hoffman, Thomas Kahan, Jonas Spaak
INTRODUCTION: Aortic stiffness plays a critical role in the evolution of cardiovascular diseases, but the assessment requires specialized equipment. Photoplethysmography (PPG) and single-lead electrocardiogram (ECG) are readily available in healthcare and wearable devices. We studied whether a brief PPG registration, alone or in combination with single-lead ECG, could be used to reliably estimate aortic stiffness. METHODS: A proof-of-concept study with simultaneous high-resolution index finger recordings of infrared PPG, single-lead ECG, and finger blood pressure (Finapres) was performed in 33 participants [median age 44 (range 21-66) years, 19 men] and repeated within 2 weeks...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38529331/study-on-the-related-factors-of-tcm-constitution-and-hemodynamics-in-patients-with-coronary-heart-disease
#16
JOURNAL ARTICLE
Boyan Mao, Zhou Zhao, Minghui Wei, Xinzhu Liu, Ruoqi Zhao, Weipeng Zhang, Mengyao Duan
BACKGROUND: The concepts of "individualization" and "preventive treatment" should be incorporated into the precise diagnosis and treatment of coronary heart disease (CHD). Both hemodynamics and Chinese medicine constitution studies align with these two concepts. METHODS: This study utilized data from 81 patients with CHD, including 12 patients with balanced constitution (BC), 20 patients with blood stasis constitution (BSC), 17 patients with phlegm-dampness constitution (PDC), 15 patients with qi-deficiency constitution (QDC), and 17 patients with other constitutions...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38529330/corrigendum-regional-myocardial-work-measured-by-echocardiography-for-the-detection-of-myocardial-ischemic-segments-a-comparative-study-with-invasive-fractional-flow-reserve
#17
Ying Guo, Chenguang Yang, Xiang Wang, Zuowei Pei, Huolan Zhu, Xuyang Meng, Ziyu Zhou, Xiaotong Lang, Sun Ning, Ruisheng Zhang, Fang Wang
[This corrects the article DOI: 10.3389/fcvm.2022.813710.].
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38529329/recent-advances-of-myotubularin-related-mtmr-protein-family-in-cardiovascular-diseases
#18
REVIEW
Jia Wang, Wei Guo, Qiang Wang, Yongjian Yang, Xiongshan Sun
Belonging to a lipid phosphatase family containing 16 members, myotubularin-related proteins (MTMRs) are widely expressed in a variety of tissues and organs. MTMRs preferentially hydrolyzes phosphatidylinositol 3-monophosphate and phosphatidylinositol (3,5) bis-phosphate to generate phosphatidylinositol and phosphatidylinositol 5-monophosphate, respectively. These phosphoinositides (PIPs) promote membrane degradation during autophagosome-lysosomal fusion and are also involved in various regulatory signal transduction...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38525193/effects-of-continuous-supplementation-of-acanthopanax-senticosus-harms-on-the-cardiac-autonomic-function-of-community-dwelling-elderly-individuals-during-resting-and-standing-tests-a-randomized-controlled-trial
#19
JOURNAL ARTICLE
Takeru Sato, Takumi Aoki, Yuki Ito, Kan Oishi, Masaki Fujishima, Eri Okumura, Kojiro Ishii
BACKGROUND: Cardiac autonomic function (CAF) decreases with aging, and Acanthopanax senticosus Harms (ASH) consumption reportedly induces anti-stress effects. This study aimed to assess the effect of continuous supplementation of ASH on CAF during resting and standing tests in the elderly population. METHODS: This double-blind, randomized controlled trial was conducted in the morning in a laboratory setting and was carried out between June 2017 and July 2017 at Kambaikan, Doshisha University (Karasuma-higashi-iru, Imadegawa-dori, Kamigyo-ku, Kyoto 602-8580, Japan)...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38525192/mendelian-randomization-supports-genetic-liability-to-hospitalization-for-covid-19-as-a-risk-factor-of-pre-eclampsia
#20
JOURNAL ARTICLE
Weizhen Wu, Junning Zhang, Yizhuo Qiao, Yuehan Ren, Xuezhi Rao, Zhijie Xu, Baoxing Liu
BACKGROUND: Pre-eclampsia and eclampsia are among the major threats to pregnant women and fetuses, but they can be mitigated by prevention and early screening. Existing observational research presents conflicting evidence regarding the causal effects of coronavirus disease 2019 (COVID-19) on pre-eclampsia risk. Through Mendelian randomization (MR), this study aims to investigate the causal effect of three COVID-19 severity phenotypes on the risk of pre-eclampsia and eclampsia to provide more rigorous evidence...
2024: Frontiers in Cardiovascular Medicine
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