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Frontiers in Cardiovascular Medicine

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https://www.readbyqxmd.com/read/30109235/cerebrovascular-events-after-transcatheter-aortic-valve-implantation
#1
REVIEW
German Armijo, Luis Nombela-Franco, Gabriela Tirado-Conte
Transcatheter aortic valve implantation (TAVI) has emerged as an alternative less invasive treatment for patients with symptomatic severe aortic stenosis. Despite the technological development and knowledge improvement in recent years, neurological complications remain a concern, especially with the expansion of the technique toward younger and lower risk patients. Clinical cerebrovascular events have an important impact on patients' morbidity and mortality with a multifactorial origin. While cerebral microembolizations during TAVI is a universal phenomenon and embolic protection devices have been developed in an attempt to reduce them, their clinical utility remains unclear...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30094241/characteristics-and-prognosis-of-exercise-related-sudden-cardiac-arrest
#2
Tomi M Toukola, Janna P Kauppila, Lasse Pakanen, Marja-Leena Kortelainen, Matti Martikainen, Heikki V Huikuri, M Juhani Junttila
Introduction: The previous studies about exercise-related sudden cardiac arrest (SCA) have mainly focused on sports activity, but information related to SCA in other forms of physical exercise is lacking. Our aim was to identify characteristics and prognosis of SCA victims in the general population who suffered SCA during physical activity. Methods and results: We collected retrospectively all cases of attempted resuscitation in Oulu University Hospital Area between 2007 and 2012. A total of 300 cases were of cardiac origin...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30094240/commentary-decomposition-of-heart-rate-variability-spectrum-into-a-power-law-function-and-a-residual-spectrum
#3
COMMENT
Paolo Castiglioni
No abstract text is available yet for this article.
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30087900/tavi-simplification-is-the-ultimate-sophistication
#4
REVIEW
Mariama Akodad, Thierry Lefèvre
Since its introduction in 2002, TAVI has evolved dramatically and is now standard of care for intermediate risk patients when the femoral approach can be implemented safely. The development of innovative transcatheter heart valves (THVs) and refinement of technical skills have contributed to the decrease in complication rates associated with TAVI4 . Increased experience, smaller sheaths, rigorous pre-procedural planning and improved vascular closing techniques have resulted in markedly lower rates of vascular complications...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30087899/aldh1a3-is-the-key-isoform-that-contributes-to-aldehyde-dehydrogenase-activity-and-affects-in-vitro-proliferation-in-cardiac-atrial-appendage-progenitor-cells
#5
Stefania Puttini, Isabelle Plaisance, Lucio Barile, Elisabetta Cervio, Giuseppina Milano, Paola Marcato, Thierry Pedrazzini, Giuseppe Vassalli
High aldehyde dehydrogenase (ALDHhi ) activity has been reported in normal and cancer stem cells. We and others have shown previously that human ALDHhi cardiac atrial appendage cells are enriched with stem/progenitor cells. The role of ALDH in these cells is poorly understood but it may come down to the specific ALDH isoform(s) expressed. This study aimed to compare ALDHhi and ALDHlo atrial cells and to identify the isoform(s) that contribute to ALDH activity, and their functional role. Methods and Results: Cells were isolated from atrial appendage specimens from patients with ischemic and/or valvular heart disease undergoing heart surgery...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30083537/transcatheter-treatment-of-tricuspid-valve-disease-an-unmet-need-the-surgical-point-of-view
#6
David C Reineke, Eva Roost, Florian Schoenhoff, Miralem Pasic, Alex Kadner, Lars Englberger, Thierry P Carrel
No abstract text is available yet for this article.
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30073171/targeting-postprandial-hyperglycemia-with-physical-activity-may-reduce-cardiovascular-disease-risk-but-what-should-we-do-and-when-is-the-right-time-to-move
#7
REVIEW
Thomas P J Solomon, Frank F Eves, Matthew J Laye
Physical inactivity and excessive postprandial hyperglycemia are two major independent risk factors for type 2 diabetes and cardiovascular-related mortality. Current health policy guidelines recommend at least 150 min of physical activity per week coupled with reduced daily sedentary behavior by interrupting prolonged sitting with bouts of light activity every 30-min. This evidence-based strategy promotes health and quality of life. Since modern lifestyle enforces physical inactivity through motorized transportation and seated office working environments, this review examines the practical strategies (standing, walking, stair climbing, and strength-based circuit exercises) for reducing sitting time and increasing activity during the workday...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30073170/transcatheter-treatment-of-bicuspid-aortic-valve-disease-imaging-and-interventional-considerations
#8
Rajiv Das, Rishi Puri
Patients with bicuspid aortic valve disease have systematically been excluded from large randomized clinical trials investigating transcatheter aortic valve implantation (TAVI) due to their younger age, lower surgical risk and complex aortic anatomy. The asymmetric nature of the bicuspid valve orifice often accompanied by heavy regional calcification has led to concerns regarding valve positioning and expansion. Bicuspid aortic valve disease patients are at heightened risk of TAVI-related complications including coronary occlusion, aortic dissection and annular rupture, as well as the known risks of progressive aortopathy in these patients...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30065930/editorial-mechanisms-and-implications-of-the-aging-of-cardiovascular-regenerative-cells
#9
EDITORIAL
Antonio P Beltrami, Gaia Spinetti
No abstract text is available yet for this article.
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30065929/integrating-genes-affecting-coronary-artery-disease-in-functional-networks-by-multi-omics-approach
#10
REVIEW
Baiba Vilne, Heribert Schunkert
Coronary artery disease (CAD) and myocardial infarction (MI) remain among the leading causes of mortality worldwide, urgently demanding a better understanding of disease etiology, and more efficient therapeutic strategies. Genetic predisposition as well as the environment and lifestyle are thought to contribute to disease risk. It is likely that non-linear and complex interactions occur between these multiple factors, involving simultaneous pathological changes in diverse cell types, tissues, and organs, at multiple molecular levels...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30065928/access-sites-for-tavi-patient-selection-criteria-technical-aspects-and-outcomes
#11
REVIEW
Luigi Biasco, Enrico Ferrari, Giovanni Pedrazzini, Francesco Faletra, Tiziano Moccetti, Francesco Petracca, Marco Moccetti
During the last ten years, transcatheter aortic valve implantation (TAVI) has become a reliable and valid alternative treatment for elderly patients with severe symptomatic aortic valve stenosis requiring valve replacement and being at high or intermediate surgical risk. While common femoral arteries are the access site of choice in the vast majority of TAVI patients, in up to 15-20% of TAVI candidates this route might be precluded due to the presence of diffuse atherosclerotic disease, tortuosity or small vessel diameter...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30062098/commentary-microrna-221-222-family-counteracts-myocardial-fibrosis-in-pressure-overload-induced-heart-failure
#12
COMMENT
Boris Schmitz, Stefan-Martin Brand
No abstract text is available yet for this article.
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30050909/expanding-tavi-to-low-and-intermediate-risk-patients
#13
REVIEW
Lisa Voigtländer, Moritz Seiffert
TAVI has become the standard treatment in patients at increased surgical risk and is increasingly being performed in patients at intermediate to low surgical risk. While non-inferiority has been demonstrated in intermediate risk patients, several challenges-particularly with regard to valve durability-need to be addressed before expansion to lower risk and younger patients can be recommended on a broad basis. Current trends, trials results, and remaining challenges are summarized and discussed in the light of updated treatment guidelines...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30050908/vitamin-d-supplementation-serum-25-oh-d-concentrations-and-cardiovascular-disease-risk-factors-a-systematic-review-and-meta-analysis
#14
Naghmeh Mirhosseini, Jacqueline Rainsbury, Samantha M Kimball
Background: Cardiovascular disease (CVD) risk factors are associated with low serum 25 hydroxyvitamin D (25(OH)D) concentrations in observational studies; however, clinical trial findings are inconsistent. Objective: We assessed the effect of vitamin D supplementation and increased serum 25(OH)D concentrations on CVD risk factors in a systemic review and meta-analysis of randomized controlled trials (RCTs). Design: MEDLINE, CINAHL, EMBASE, and Google Scholar were searched for RCTs that evaluated vitamin D supplementation and cardiovascular outcomes [blood pressure, parathyroid hormone (PTH), serum high-sensitivity C-reactive protein (hs-CRP), total cholesterol, high and low density lipoprotein (HDL and LDL, respectively), triglycerides, peak wave velocity (PWV) and Augmentation Index (AI)] from 1992 through 2017...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30038909/erratum-the-regulation-of-insulin-stimulated-cardiac-glucose-transport-via-protein-acetylation
#15
(no author information available yet)
[This corrects the article DOI: 10.3389/fcvm.2018.00070.].
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30038908/radiation-matters-of-the-heart-a-mini-review
#16
REVIEW
Kareena M Menezes, Huichen Wang, Megumi Hada, Premkumar B Saganti
Radiation Therapy (RT) has been critical in cancer treatment regimens to date. However, it has been shown that ionizing radiation is also associated with increased risk of damage to healthy tissues. At high radiation doses, varied effects including inactivation of cells in treated tissue and associated functional impairment are seen. These range from direct damage to the heart; particularly, diffuse fibrosis of the pericardium and myocardium, adhesion of the pericardium, injury to the blood vessels and stenosis...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30038907/no-significant-role-for-smooth-muscle-cell-mineralocorticoid-receptors-in-atherosclerosis-in-the-apolipoprotein-e-knockout-mouse-model
#17
M Elizabeth Moss, Jennifer J DuPont, Surabhi L Iyer, Adam P McGraw, Iris Z Jaffe
Objective: Elevated levels of the hormone aldosterone are associated with increased risk of myocardial infarction and stroke in humans and increased progression and inflammation of atherosclerotic plaques in animal models. Aldosterone acts through the mineralocorticoid receptor (MR) which is expressed in vascular smooth muscle cells (SMCs) where it promotes SMC calcification and chemokine secretion in vitro . The objective of this study is to explore the role of the MR specifically in SMCs in the progression of atherosclerosis and the associated vascular inflammation in vivo in the apolipoprotein E knockout (ApoE-/- ) mouse model...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30018970/future-perspectives-on-the-role-of-stem-cells-and-extracellular-vesicles-in-vascular-tissue-regeneration
#18
REVIEW
Eoghan M Cunnane, Justin S Weinbaum, Fergal J O'Brien, David A Vorp
Vascular tissue engineering is an area of regenerative medicine that attempts to create functional replacement tissue for defective segments of the vascular network. One approach to vascular tissue engineering utilizes seeding of biodegradable tubular scaffolds with stem (and/or progenitor) cells wherein the seeded cells initiate scaffold remodeling and prevent thrombosis through paracrine signaling to endogenous cells. Stem cells have received an abundance of attention in recent literature regarding the mechanism of their paracrine therapeutic effect...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30018969/tavi-and-post-procedural-cardiac-conduction-abnormalities
#19
REVIEW
Antonio Mangieri, Claudio Montalto, Matteo Pagnesi, Giuseppe Lanzillo, Ozan Demir, Luca Testa, Antonio Colombo, Azeem Latib
Transcatheter aortic valve implantation (TAVI) is a worldwide accepted alternative for treating patients at intermediate or high risk for surgery. In recent years, the rate of complications has markedly decreased except for new-onset atrioventricular and intraventricular conduction block that remains the most common complication after TAVI. Although procedural, clinical, and electrocardiographic predisposing factors have been identified as predictors of conduction disturbances, new strategies are needed to avoid such complications, particularly in the current TAVI era that is moving quickly toward the percutaneous treatment of low-risk patients...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30018968/case-study-intra-patient-heterogeneity-of-aneurysmal-tissue-properties
#20
Giampaolo Martufi, Arianna Forneris, Samaneh Nobakht, Kristina D Rinker, Randy D Moore, Elena S Di Martino
Introduction: Current recommendations for surgical treatment of abdominal aortic aneurysms (AAAs) rely on the assessment of aortic diameter as a marker for risk of rupture. The use of aortic size alone may overlook the role that vessel heterogeneity plays in aneurysmal progression and rupture risk. The aim of the current study was to investigate intra-patient heterogeneity of mechanical and fluid mechanical stresses on the aortic wall and wall tissue histopathology from tissue collected at the time of surgical repair...
2018: Frontiers in Cardiovascular Medicine
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