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Frontiers in Cardiovascular Medicine

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https://www.readbyqxmd.com/read/29230400/perspectives-of-post-acute-transition-of-care-for-cardiac-surgery-patients
#1
REVIEW
Nicoleta Stoicea, Tian You, Andrew Eiterman, Clifton Hartwell, Victor Davila, Stephen Marjoribanks, Cristina Florescu, Sergio Daniel Bergese, Barbara Rogers
Post-acute care (PAC) facilities improve patient recovery, as measured by activities of daily living, rehabilitation, hospital readmission, and survival rates. Seamless transitions between discharge and PAC settings continue to be challenges that hamper patient outcomes, specifically problems with effective communication and coordination between hospitals and PAC facilities at patient discharge, patient adherence and access to cardiac rehabilitation (CR) services, caregiver burden, and the financial impact of care...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29209618/platelet-derived-microvesicles-in-cardiovascular-diseases
#2
REVIEW
Maria T K Zaldivia, James D McFadyen, Bock Lim, Xiaowei Wang, Karlheinz Peter
Microvesicles (MVs) circulating in the blood are small vesicles (100-1,000 nm in diameter) derived from membrane blebs of cells such as activated platelets, endothelial cells, and leukocytes. A growing body of evidence now supports the concept that platelet-derived microvesicles (PMVs), the most abundant MVs in the circulation, are important regulators of hemostasis, inflammation, and angiogenesis. Compared with healthy individuals, a large increase of circulating PMVs has been observed, particularly in patients with cardiovascular diseases...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29209617/mirroring-the-multiple-potentials-of-micrornas-in-acute-myocardial-infarction
#3
REVIEW
Solenne Paiva, Onnik Agbulut
At present, cardiovascular diseases are depicted to be the leading cause of death worldwide according to the World Health Organization. In the future, projections predict that ischemic heart disease will persist in the top main causes of illness. Within this alarming context, some tiny master regulators of gene expression programs, namely, microRNAs (miRNAs) carry three promising potentials. In fact, miRNAs can prove to be useful not only in terms of biomarkers allowing heart injury detection but also in terms of therapeutics to overcome limitations of past strategies and treat the lesions...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29209616/extracellular-vesicles-as-protagonists-of-diabetic-cardiovascular-pathology
#4
REVIEW
Dakota Gustafson, Shawn Veitch, Jason E Fish
Extracellular vesicles (EVs) represent an emerging mechanism of cell-cell communication in the cardiovascular system. Recent data suggest that EVs are produced and taken up by multiple cardiovascular cell types, influencing target cells through signaling or transfer of cargo (including proteins, lipids, messenger RNA, and non-coding RNA). The concentration and contents of circulating EVs are altered in several diseases and represent explicit signatures of cellular activation, making them of particular interest as circulating biomarkers...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29181379/molecular-autopsy-for-sudden-death-in-the-young-is-data-aggregation-the-key
#5
Manuel Rueda, Jennifer L Wagner, Tierney C Phillips, Sarah E Topol, Evan D Muse, Jonathan R Lucas, Glenn N Wagner, Eric J Topol, Ali Torkamani
The Scripps molecular autopsy study seeks to incorporate genetic testing into the postmortem examination of cases of sudden death in the young (<45 years old). Here, we describe the results from the first 2 years of the study, which consisted of whole exome sequencing (WES) of a cohort of 50 cases predominantly from San Diego County. Apart from the individual description of cases, we analyzed the data at the cohort-level, which brought new perspectives on the genetic causes of sudden death. We investigated the advantages and disadvantages of using WES compared to a gene panel for cardiac disease (usually the first genetic test used by medical examiners)...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29164136/factors-associated-with-health-related-quality-of-life-among-hypertensive-patients-in-kathmandu-nepal
#6
Saruna Ghimire, Praful Pradhananga, Binaya Kumar Baral, Naveen Shrestha
Introduction: Nepal has a high prevalence of hypertension. While improving the overall health-related quality of life (HRQOL) is a central tenet to public health plans in developed nations, this focus has yet to be articulated in Nepal. Therefore, this study aims to identify the factors associated with HRQOL among hypertensive patients in Nepal. Method: The EuroQol-5Dimension HRQOL survey was administered to 180 hypertensive patients, attending the outpatient clinic at Shahid Gangalal National Heart Center in Kathmandu, Nepal...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29164135/a-protocol-for-improved-precision-and-increased-confidence-in-nanoparticle-tracking-analysis-concentration-measurements-between-50-and-120%C3%A2-nm-in-biological-fluids
#7
Martin E M Parsons, Damien McParland, Paulina B Szklanna, Matthew Ho Zhi Guang, Karen O'Connell, Hugh D O'Connor, Christopher McGuigan, Fionnuala Ní Áinle, Amanda McCann, Patricia B Maguire
Nanoparticle tracking analysis (NTA) can be used to quantitate extracellular vesicles (EVs) in biological samples and is widely considered a useful diagnostic tool to detect disease. However, accurately profiling EVs can be challenging due to their small size and heterogeneity. Here, we aimed to provide a protocol to facilitate high-precision particle quantitation by NTA in plasma, the supernatant of activated purified platelets [the platelet releasate (PR)] and in serum, to increase confidence in NTA particle enumeration...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29164134/cancer-and-thrombotic-risk-the-platelet-paradigm
#8
REVIEW
Elizabeth C Lee, Scott J Cameron
Hematologic malignancies and solid tumors increase the risk of venous and arterial thrombosis and contribute greatly to patient morbidity and mortality. Thrombosis occurs when the intricate balance of circulating antithrombotic and prothrombotic blood elements are disrupted. In recent years, the interplay between paraneoplastic cells and platelets has become apparent, with a change in platelet phenotype causing dysregulated platelet activity. This review discusses mechanism of thrombosis in cancer, evidence for using drug therapy, and exciting research efforts to understand and hopefully control aberrant thrombotic events in patients with cancer...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29164133/role-of-dietary-antioxidants-in-the-preservation-of-vascular-function-and-the-modulation-of-health-and-disease
#9
REVIEW
Saradhadevi Varadharaj, Owen J Kelly, Rami N Khayat, Purnima S Kumar, Naseer Ahmed, Jay L Zweier
In vascular diseases, including hypertension and atherosclerosis, vascular endothelial dysfunction (VED) occurs secondary to altered function of endothelial nitric oxide synthase (eNOS). A novel redox regulated pathway was identified through which eNOS is uncoupled due to S-glutathionylation of critical cysteine residues, resulting in superoxide free radical formation instead of the vasodilator molecule, nitric oxide. In addition, the redox sensitive cofactor tetrahydrobiopterin, BH4, is also essential for eNOS coupling...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29124057/radiation-induced-cardiovascular-disease-a-clinical-perspective
#10
REVIEW
Syed Wamique Yusuf, Bhanu Prasad Venkatesulu, Lakshmi Shree Mahadevan, Sunil Krishnan
Cancer survival has improved dramatically, and this has led to the manifestation of late side effects of multimodality therapy. Radiation (RT) to the thoracic malignancies results in unintentional irradiation of the cardiac chambers. RT-induced microvascular ischemia leads to disruption of capillary endothelial framework, and injury to differentiated myocytes results in deposition of collagen and fibrosis. Coexistence of risk factors of metabolic syndrome and preexisting atherosclerosis in addition to RT exposure results in accelerated occurrence of major coronary events...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29114540/angiogenesis-cancer-and-vascular-aging
#11
REVIEW
Junji Moriya, Tohru Minamino
Several lines of evidence have revealed that the angiogenic response to ischemic injury declines with age, which might account for the increased morbidity and mortality of cardiovascular disease (CVD) among the elderly. While impairment of angiogenesis with aging leads to delayed wound healing or exacerbation of atherosclerotic ischemic diseases, it also inhibits the progression of cancer. Age-related changes of angiogenesis have been considered to at least partly result from vascular aging or endothelial cell senescence...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29062835/toward-exosome-based-therapeutics-isolation-heterogeneity-and-fit-for-purpose-potency
#12
Gareth R Willis, Stella Kourembanas, S Alex Mitsialis
Exosomes are defined as submicron (30-150 nm), lipid bilayer-enclosed extracellular vesicles (EVs), specifically generated by the late endosomal compartment through fusion of multivesicular bodies with the plasma membrane. Produced by almost all cells, exosomes were originally considered to represent just a mechanism for jettisoning unwanted cellular moieties. Although this may be a major function in most cells, evolution has recruited the endosomal membrane-sorting pathway to duties beyond mere garbage disposal, one of the most notable examples being its cooption by retroviruses for the generation of Trojan virions...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29057227/getting-old-through-the-blood-circulating-molecules-in-aging-and-senescence-of-cardiovascular-regenerative-cells
#13
REVIEW
Francesco Angelini, Francesca Pagano, Antonella Bordin, Vittorio Picchio, Elena De Falco, Isotta Chimenti
Global aging is a hallmark of our century. The natural multifactorial process resulting in aging involves structural and functional changes, affecting molecules, cells, and tissues. As the western population is getting older, we are witnessing an increase in the burden of cardiovascular events, some of which are known to be directly linked to cellular senescence and dysfunction. In this review, we will focus on the description of a few circulating molecules, which have been correlated to life span, aging, and cardiovascular homeostasis...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29038784/epistemology-of-natural-strategies-for-cardiac-tissue-repair
#14
Michele M Ciulla
No abstract text is available yet for this article.
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28993808/micrornas-new-players-in-the-pathobiology-of-preeclampsia
#15
REVIEW
Kelsey R Bounds, Valorie L Chiasson, Lu J Pan, Sudhiranjan Gupta, Piyali Chatterjee
Our understanding of how microRNAs (miRNAs) regulate gene networks and affect different molecular pathways leading to various human pathologies has significantly improved over the years. In contrary, the role of miRNAs in pregnancy-related hypertensive disorders such as preeclampsia (PE) is only beginning to emerge. Recent papers highlight that adverse pregnancy outcomes are associated with aberrant expression of several miRNAs. Presently, efforts are underway to determine the biologic function of these placental miRNAs which can shed light on their contribution to these pregnancy-related disease conditions...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28979899/complete-resolution-of-a-large-bicuspid-aortic-valve-thrombus-with-anticoagulation-in-primary-antiphospholipid-syndrome
#16
Rayan Jo Rachwan, Ghassan E Daher, Jawad Fares, Rachoin Rachoin
Native aortic valve thrombosis in primary antiphospholipid syndrome (APLS) is a rare entity. We describe a 38-year-old man who presented with neurological symptoms and a cardiac murmur. Transthoracic echocardiography detected a large bicuspid aortic valve thrombus. Laboratory evaluation showed the presence of antiphospholipid antibodies. Anticoagulation was started, and serial echocardiographic studies showed complete resolution of the aortic valve vegetation after 4 months. The patient improved clinically and had no residual symptoms...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28979898/a-novel-mutation-in-foxc1-in-a-lebanese-family-with-congenital-heart-disease-and-anterior-segment-dysgenesis-potential-roles-for-nfatc1-and-dpt-in-the-phenotypic-variations
#17
Athar Khalil, Christiane Al-Haddad, Hadla Hariri, Kamel Shibbani, Fadi Bitar, Mazen Kurban, Georges Nemer, Mariam Arabi
Congenital heart diseases (CHDs) are still the leading cause of death in neonates. Anterior segment dysgenesis is a broad clinical phenotype that affects the normal development of the eye, leading in most of the cases to glaucoma which is still a major cause of blindness for children and adolescents. Despite tremendous insights gained from genetic studies, a clear genotype-phenotype correlation is still difficult to draw. In Lebanon, a small country with still a high rate of consanguineous marriages, there are little data on the epidemiology of glaucoma amongst children with or without CHD...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28979897/genome-wide-association-analysis-for-severity-of-coronary-artery-disease-using-the-gensini-scoring-system
#18
Tanja Zeller, Moritz Seiffert, Christian Müller, Markus Scholz, Anna Schäffer, Francisco Ojeda, Heinz Drexel, Axel Mündlein, Marcus E Kleber, Winfried März, Christoph Sinning, Fabian J Brunner, Christoph Waldeyer, Till Keller, Christoph H Saely, Karsten Sydow, Joachim Thiery, Daniel Teupser, Stefan Blankenberg, Renate Schnabel
Coronary artery disease (CAD) has a complex etiology involving numerous environmental and genetic factors of disease risk. To date, the genetic 9p21 locus represents the most robust genetic finding for prevalent and incident CAD. However, limited information is available on the genetic background of the severity and distribution of CAD. CAD manifests itself as stable CAD or acute coronary syndrome. The Gensini score quantifies the extent CAD but requires coronary angiography. Here, we aimed to identify novel genetic variants associated with Gensini score severity and distribution of CAD...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28944224/the-relationship-between-parental-rearing-behavior-resilience-and-depressive-symptoms-in-adolescents-with-congenital-heart-disease
#19
Ju Ryoung Moon, Jinyoung Song, June Huh, I-Seok Kang, Seung Woo Park, Sung-A Chang, Ji-Hyuk Yang, Tae-Gook Jun
OBJECTIVES: Parental rearing behavior is one factor that influences the strength of resilience. In turn, resilience influences depression. However, it is unclear whether resilience has a mediating effect on the relationship between parental rearing and depression in adolescents with congenital heart disease (CHD). Therefore, the associations between parental rearing behavior and resilience and between rearing behavior and symptoms of depression were investigated with respect to age, gender and disease severity...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28936433/trpc3-channels-in-cardiac-fibrosis
#20
REVIEW
Takuro Numaga-Tomita, Sayaka Oda, Tsukasa Shimauchi, Akiyuki Nishimura, Supachoke Mangmool, Motohiro Nishida
Cardiac stiffness, caused by interstitial fibrosis due to deposition of extracellular matrix proteins, is thought as a major clinical outcome of heart failure with preserved ejection fraction (HFpEF). Canonical transient receptor potential (TRPC) subfamily proteins are components of Ca(2+)-permeable non-selective cation channels activated by receptor stimulation and mechanical stress, and have been attracted attention as a key mediator of maladaptive cardiac remodeling. How TRPC-mediated local Ca(2+) influx encodes a specific signal to induce maladaptive cardiac remodeling has been long obscure, but our recent studies suggest a pathophysiological significance of channel activity-independent function of TRPC proteins for amplifying redox signaling in heart...
2017: Frontiers in Cardiovascular Medicine
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