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Frontiers in Cardiovascular Medicine

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https://www.readbyqxmd.com/read/27933299/strategy-to-prime-the-host-and-cells-to-augment-therapeutic-efficacy-of-progenitor-cells-for-patients-with-myocardial-infarction
#1
REVIEW
Jeehoon Kang, Tae-Won Kim, Jin Hur, Hyo-Soo Kim
Cell therapy in myocardial infarction (MI) is an innovative strategy that is regarded as a rescue therapy to repair the damaged myocardium and to promote neovascularization for the ischemic border zone. Among several stem cell sources for this purpose, autologous progenitors from bone marrow or peripheral blood would be the most feasible and safest cell-source. Despite the theoretical benefit of cell therapy, this method is not widely adopted in the actual clinical practice due to its low therapeutic efficacy...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27900323/unexpected-dual-left-anterior-descending-artery-as-a-source-of-percutaneous-coronary-revascularization-failure
#2
Steven D Hajdu, Salah D Qanadli
Dual left anterior descending artery (LAD) is rare. A 61-year-old patient was referred because of angina and a positive stress test. Coronary angiography revealed a short LAD originating from the left main coronary artery. Computed tomography showed a long LAD originating above the right coronary artery sinus.
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27867942/quantification-of-calcified-particles-in-human-valve-tissue-reveals-asymmetry-of-calcific-aortic-valve-disease-development
#3
Katsumi Yabusaki, Joshua D Hutcheson, Payal Vyas, Sergio Bertazzo, Simon C Body, Masanori Aikawa, Elena Aikawa
Recent studies indicated that small calcified particles observable by scanning electron microscopy (SEM) may initiate calcification in cardiovascular tissues. We hypothesized that if the calcified particles precede gross calcification observed in calcific aortic valve disease (CAVD), they would exhibit a regional asymmetric distribution associated with CAVD development, which always initiates at the base of aortic valve leaflets adjacent to the aortic outflow in a region known as the fibrosa. Testing this hypothesis required counting the calcified particles in histological sections of aortic valve leaflets...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27833913/glycemic-control-with-ipragliflozin-a-novel-selective-sglt2-inhibitor-ameliorated-endothelial-dysfunction-in-streptozotocin-induced-diabetic-mouse
#4
Hotimah Masdan Salim, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro, Masataka Sata
BACKGROUND: Endothelial dysfunction caused by increased oxidative stress is a critical initiator of macro- and micro-vascular disease development in diabetic patients. Ipragliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, offers a novel approach for the treatment of diabetes by enhancing urinary glucose excretion. The aim of this study was to examine whether ipragliflozin attenuates endothelial dysfunction in diabetic mice. METHODS: Eight-week-old male C57BL/6 mice were treated with streptozotocin (150 mg/kg) by a single intraperitoneal injection to induce diabetes mellitus...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27818991/percutaneous-device-to-narrow-the-coronary-sinus-shifting-paradigm-in-the-treatment-of-refractory-angina-a-review-of-the-literature
#5
Daniela Benedetto, Masieh Abawi, Pieter R Stella, Freek Nijhoff, Maxime D M Lakemeier, Friso Kortlandt, Pieter A Doevendans, Pierfrancesco Agostoni
Refractory angina pectoris is defined as a chronic debilitating condition characterized by the presence of chronic anginal symptoms due to a severe obstructive and/or diffuse coronary artery disease that cannot be controlled by the combination of medical therapy and/or revascularization (percutaneous or surgical). In addition, the presence of myocardial ischemia as a cause of the symptoms must have been documented. The coronary sinus reducer (CSR) is a recently introduced percutaneous device to treat patients with severe anginal symptoms refractory to optimal medical therapy and not amenable to conventional revascularization...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27807535/rat-heterotopic-heart-transplantation-model-to-investigate-unloading-induced-myocardial-remodeling
#6
REVIEW
Xuebin Fu, Adrian Segiser, Thierry P Carrel, Hendrik T Tevaearai Stahel, Henriette Most
Unloading of the failing left ventricle in order to achieve myocardial reverse remodeling and improvement of contractile function has been developed as a strategy with the increasing frequency of implantation of left ventricular assist devices in clinical practice. But, reverse remodeling remains an elusive target, with high variability and exact mechanisms still largely unclear. The small animal model of heterotopic heart transplantation (hHTX) in rodents has been widely implemented to study the effects of complete and partial unloading on cardiac failing and non-failing tissue to better understand the structural and molecular changes that underlie myocardial recovery...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27800483/tocotrienol-rich-tocomin-attenuates-oxidative-stress-and-improves-endothelium-dependent-relaxation-in-aortae-from-rats-fed-a-high-fat-western-diet
#7
Saher F Ali, Jason C D Nguyen, Trisha A Jenkins, Owen L Woodman
We have previously reported that tocomin, a mixture high in tocotrienol content and also containing tocopherol, acutely preserves endothelial function in the presence of oxidative stress. In this study, we investigated whether tocomin treatment would preserve endothelial function in aortae isolated from rats fed a high-fat diet known to cause oxidative stress. Wistar hooded rats were fed a western diet (WD, 21% fat) or control rat chow (standard diet, 6% fat) for 12 weeks. Tocomin (40 mg/kg/day sc) or its vehicle (peanut oil) was administered for the last 4 weeks of the feeding regime...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27790620/immune-modulation-of-cardiac-repair-and-regeneration-the-art-of-mending-broken-hearts
#8
REVIEW
Ivana Zlatanova, Cristina Pinto, Jean-Sébastien Silvestre
The accumulation of immune cells is among the earliest responses that manifest in the cardiac tissue after injury. Both innate and adaptive immunity coordinate distinct and mutually non-exclusive events governing cardiac repair, including elimination of the cellular debris, compensatory growth of the remaining cardiac tissue, activation of resident or circulating precursor cells, quantitative and qualitative modifications of the vascular network, and formation of a fibrotic scar. The present review summarizes the mounting evidence suggesting that the inflammatory response also guides the regenerative process following cardiac damage...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27790619/sirt3-in-cardiac-physiology-and-disease
#9
REVIEW
Christoph Koentges, Christoph Bode, Heiko Bugger
Functional defects in mitochondrial biology causally contribute to various human diseases, including cardiovascular disease. Impairment in oxidative phosphorylation, mitochondrial oxidative stress, and increased opening of the mitochondrial permeability transition pore add to the underlying mechanisms of heart failure or myocardial ischemia-reperfusion (IR) injury. Recent evidence demonstrated that the mitochondrial NAD(+)-dependent deacetylase sirtuin 3 (SIRT3) may regulate these mitochondrial functions by reversible protein lysine deacetylation...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27777932/multi-biomarker-profiling-and-recurrent-hospitalizations-in-heart-failure
#10
Antoni Bayes-Genis, Julio Núñez, Eduardo Núñez, Jaume Barallat Martínez, Maria-Cruz Pastor Ferrer, Marta de Antonio, Elisabet Zamora, Juan Sanchis, Josep Lupón Rosés
BACKGROUND: Despite advances in pharmacologic therapy and devices, patients with heart failure (HF) continue to have significant rehospitalization rates and risk prediction remains challenging. We sought to explore the value of a multi-biomarker panel [including NT-proBNP, high-sensitivity cardiac troponin T (hs-TnT), and ST2] on top of clinical assessment for long-term prediction of recurrent hospitalizations in HF. METHODS AND RESULTS: NT-proBNP, hs-TnT, and ST2 (suppression of tumorigenicity-2) levels were measured in 891 consecutive ambulatory HF patients...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27777931/mitochondrial-ros-versus-er-ros-which-comes-first-in-myocardial-calcium-dysregulation
#11
Ruchi Chaube, Geoff H Werstuck
No abstract text is available yet for this article.
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27774451/the-hyponatremia-epidemic-a-frontier-too-far
#12
Angela J Drake-Holland, Mark I M Noble
Hyponatremia is the most common electrolyte abnormality and is often neglected, especially in elderly and seemingly terminal patients. Hyponatremia can be asymptomatic or can cause symptoms ranging from nausea and lethargy to convulsions and coma. This condition has become increasingly common over time with a similar time course to the increase in adoption of low salt diets. The popularization of low salt may not be justified in people with normal kidney function in whom the compatible statistically based evidence that salt causes hypertension has been challenged by experimental evidence to the contrary...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27713880/an-algorithm-measuring-donor-cell-free-dna-in-plasma-of-cellular-and-solid-organ-transplant-recipients-that-does-not-require-donor-or-recipient-genotyping
#13
Paul M K Gordon, Aneal Khan, Umair Sajid, Nicholas Chang, Varun Suresh, Leo Dimnik, Ryan E Lamont, Jillian S Parboosingh, Steven R Martin, Richard T Pon, Jene Weatherhead, Shelly Wegener, Debra Isaac, Steven C Greenway
Cell-free DNA (cfDNA) has significant potential in the diagnosis and monitoring of clinical conditions. However, accurately and easily distinguishing the relative proportion of DNA molecules in a mixture derived from two different sources (i.e., donor and recipient tissues after transplantation) is challenging. In human cellular transplantation, there is currently no useable method to detect in vivo engraftment, and blood-based non-invasive tests for allograft rejection in solid organ transplantation are either non-specific or absent...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27703967/persistent-type-i-endoleak-after-endovascular-treatment-with-chimney-technique
#14
Ana Isabel Azevedo, Pedro Braga, Alberto Rodrigues, Nuno Ferreira, Marlene Fonseca, Adelaide Dias, Vasco Gama Ribeiro
Thoracic endovascular aortic repair (TEVAR) is increasingly used in the treatment of acute type B aortic dissection. Type Ia endoleaks are a common complication of the procedure, but its clinical significance and the best treatment strategy remain poorly defined. We present a case of a type Ia endoleak following TEVAR in the treatment of acute type B aortic dissection. Chimney technique approach was used in an attempt to seal the endoleak. Although technical success was suboptimal, the patient remained clinically stable and event free...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27703966/marked-qtc-prolongation-and-torsades-de-pointes-in-patients-with-chronic-inflammatory-arthritis
#15
Pietro Enea Lazzerini, Pier Leopoldo Capecchi, Iacopo Bertolozzi, Gabriella Morozzi, Sauro Lorenzini, Antonella Simpatico, Enrico Selvi, Maria Romana Bacarelli, Maurizio Acampa, Deana Lazaro, Nabil El-Sherif, Mohamed Boutjdir, Franco Laghi-Pasini
Mounting evidence indicates that in chronic inflammatory arthritis (CIA), QTc prolongation is frequent and correlates with systemic inflammatory activation. Notably, basic studies demonstrated that inflammatory cytokines induce profound changes in potassium and calcium channels resulting in a prolonging effect on cardiomyocyte action potential duration, thus on the QT interval on the electrocardiogram. Moreover, it has been demonstrated that in rheumatoid arthritis (RA) patients, the risk of sudden cardiac death is significantly increased when compared to non-RA subjects...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27672638/multiple-infectious-agents-and-the-origins-of-atherosclerotic-coronary-artery-disease
#16
REVIEW
James S Lawson
Although deaths due to atherosclerotic coronary artery disease (ACAD) have fallen dramatically during the past 50 years, ACAD remains as the leading cause of death in all continents, except Africa, where deaths due to infections are still dominant. Although food and nutrition have a proven role in atherosclerosis, the underlying causes of ACAD remain unknown. This is despite a century of intensive research dominated by investigations into the saturated fat hypothesis. In this review, it is hypothesized that the rise and fall in ACAD during the past 100 years is primarily due to the parallel rise and fall in the prevalence of coronary atheroma, the underlying disease...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27672637/challenges-in-molecular-diagnostics-of-channelopathies-in-the-next-generation-sequencing-era-less-is-more
#17
Valeria Novelli, Patrick Gambelli, Mirella Memmi, Carlo Napolitano
No abstract text is available yet for this article.
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27626034/systems-medicine-as-an-emerging-tool-for-cardiovascular-genetics
#18
REVIEW
Tina Haase, Daniela Börnigen, Christian Müller, Tanja Zeller
Cardiovascular disease (CVD) is a major contributor to morbidity and mortality worldwide. However, the pathogenesis of CVD is complex and remains elusive. Within the last years, systems medicine has emerged as a novel tool to study the complex genetic, molecular, and physiological interactions leading to diseases. In this review, we provide an overview about the current approaches for systems medicine in CVD. They include bioinformatical and experimental tools such as cell and animal models, omics technologies, network, and pathway analyses...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27617263/the-role-of-genetic-testing-in-the-identification-of-young-athletes-with-inherited-primitive-cardiac-disorders-at-risk-of-exercise-sudden-death
#19
REVIEW
Francesco Danilo Tiziano, Vincenzo Palmieri, Maurizio Genuardi, Paolo Zeppilli
Although relatively rare, inherited primitive cardiac disorders (IPCDs) in athletes have a deep social impact since they often present as sudden cardiac death (SCD) of young and otherwise healthy persons. The diagnosis of these conditions is likely underestimated due to the lack of shared clinical criteria and to the existence of several borderline clinical pictures. We will focus on the clinical and molecular diagnosis of the most common IPCDs, namely hypertrophic cardiomyopathies, long QT syndrome, arrhythmogenic right ventricular cardiomyopathy, and left ventricular non-compaction...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27532038/barriers-to-treatment-and-control-of-hypertension-among-hypertensive-participants-a-community-based-cross-sectional-mixed-method-study-in-municipalities-of-kathmandu-nepal
#20
Surya Devkota, Raja Ram Dhungana, Achyut Raj Pandey, Bihungum Bista, Savyata Panthi, Kartikesh Kumar Thakur, Ratna Mani Gajurel
INTRODUCTION: Despite the established evidence on benefits of controlling raised blood pressure and development of several guidelines on detection and management of hypertension, people often have untreated or uncontrolled hypertension. In this context, we undertook this study to identify the barriers existing in hypertension treatment and control in the municipalities of Kathmandu district in Nepal. METHODS: This was a community based, cross-sectional mixed method study conducted in the municipalities of Kathmandu district in Nepal between January and July 2015...
2016: Frontiers in Cardiovascular Medicine
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