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https://www.readbyqxmd.com/read/29682327/kinetics-of-circulating-cell-free-dna-for-biomedical-applications-critical-appraisal-of-the-literature
#1
REVIEW
Sonia Khier, Laura Lohan
Circulating cell-free DNA is considered as one of the major breakthroughs in the field of innovative diagnosis, used as a liquid biopsy. The kinetic parameters of a biomarker are mandatory to assess its usefulness as a diagnostic tool. Obtaining precise mathematical values for the kinetic parameters (e.g., half-life) is then crucial because it could be used for therapeutic monitoring as a prognostic factor. However, little is known about the intrinsic properties of circulating cell-free DNA, more especially, its kinetic properties within the organism...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29682326/survival-and-glycemic-control-outcomes-among-patients-with-coexisting-pancreatic-cancer-and-diabetes-mellitus
#2
Nina J Karlin, Shailja B Amin, Heidi E Kosiorek, Matthew R Buras, Patricia M Verona, Curtiss B Cook
Aim: We aimed to determine the effect of diabetes mellitus (DM) on survival in pancreatic cancer and effects of pancreatic cancer on glycemic control in DM. Materials & methods: Patients with pancreatic cancer from 2007 to 2015, with and without DM, were matched 1:1. We compared characteristics between the groups and assessed 2-year survival with Kaplan-Meier analysis. Results: In patients with DM, hemoglobin A1c decreased significantly over time (p = 0...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29682325/antimicrobial-resistance-mechanisms-and-potential-synthetic-treatments
#3
REVIEW
Junaid Ali, Qasim A Rafiq, Elizabeth Ratcliffe
Since the discovery of antibiotics by Sir Alexander Fleming they have been used throughout medicine and play a vital role in combating microorganisms. However, with their vast use, development of resistance has become more prevalent and their use is currently under threat. Antibiotic resistance poses a global threat to human and animal health, with many bacterial species having developed some form of resistance and in some cases within a year of first exposure to antimicrobial agents. This review aims to examine some of the mechanisms behind resistance...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29682324/certolizumab-pegol-in-a-heterogeneous-population-of-patients-with-moderate-to-severe-rheumatoid-arthritis
#4
Enrique R Soriano, Analia Dellepiane, Gabriela Salvatierra, Cristian Alejandro Benítez, Rodrigo Garcia Salinas, Carlos Baruzzo
Aim: To determine the efficacy and safety of certolizumab pegol for the treatment of rheumatoid arthritis in a real-world setting. Materials & methods: Patients with moderate-to-severe rheumatoid arthritis who initiated therapy with certolizumab were followed for 12 weeks. Response was assessed with Disease Activity Score of 28 joints, European Ligue Against Rheumatism criteria and Simplified Disease Activity Index. Predictors of response were analyzed with binary logistic regression models...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29682323/granulocyte-macrophage-colony-stimulating-factor-negatively-regulates-early-il-10-mediated-responses
#5
Ruud Hp Wilbers, Lotte B Westerhof, Debbie R van Raaij, Jaap Bakker, Geert Smant, Arjen Schots
Aim: Treatment of inflammatory disorders relies on the intervention in immune responses thereby restoring homeostasis. IL-10 is a cytokine with therapeutic potential, but until now has not been as successful as previously anticipated. A reason for this may be that IL-10 responsiveness depends on the environment of the inflamed tissue. In this study we investigated whether GM-CSF is able to influence IL-10-mediated responses. Methodology: Dendritic cells and macrophages were differentiated from mouse bone marrow and treated or depleted from GM-CSF prior to analyze their response to IL-10...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29682322/collection-of-analog-series-based-scaffolds-from-public-compound-sources
#6
REVIEW
Dilyana Dimova, Jürgen Bajorath
Aim: Providing a large and freely available in silico collection of analog series-based (ASB) scaffolds for computational design and medicinal chemistry applications. Methodology: Using a recently introduced computational method, ASB scaffolds with single and multiple substitution sites were systematically isolated from publicly available active compounds. Data: A total of 23,791 unique ASB scaffolds are made available in an organized and machine-readable form as an open access deposition...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29682321/use-of-biomedical-photonics-in-gynecological-surgery-a-uterine-transplantation-model
#7
Srdjan Saso, Neil T Clancy, Benjamin P Jones, Timothy Bracewell-Milnes, Maya Al-Memar, Eleanor M Cannon, Simran Ahluwalia, Joseph Yazbek, Meen-Yau Thum, Tom Bourne, Daniel S Elson, James Richard Smith, Sadaf Ghaem-Maghami
Aim: Uterine transplantation (UTx) has been proposed as a treatment for permanent absolute uterine factor infertility. The study aims were to compare pulse oximetry and multispectral imaging (MSI), for intraoperative tracking of uterine oxygen saturation in animal UTx models (rabbit and sheep). Results/methodology: Imaging results confirmed the re-establishment of adequate perfusion in the transplanted organ after surgery. Comparison of oxygen saturation   values between the pre-UTx donor and post-UTx recipient, and pre-UTx and post-UTx recipient reveals a statistically significant decrease in saturation levels post-UTx...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29682320/prevention-of-thrombotic-disorders-by-antithrombotic-diet-and-exercise-evidence-by-using-global-thrombosis-tests
#8
REVIEW
Junichiro Yamamoto, Yoshinobu Ijiri, Hideo Ikarugi, Kazunori Otsui, Nobutaka Inoue, Kjell S Sakariassen
Prevention of thrombotic disorders has priority over treatment. There are only two pathologically relevant tests which are suitable for measuring the overall thrombotic status both in experimental conditions and in humans. The Global Thrombosis Test (GTT) and the Global Parallel-Plate Thrombosis Test can detect the pathologically relevant global thrombotic status. These tests have been successfully used for monitoring the effect of antithrombotic drugs and for developing novel antithrombotic agents. By using GTT, varieties of fruits, vegetables, and regular physical exercise have been tested for the effect on global thrombotic status...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29682319/can-we-achieve-the-perfect-injectable-scaffold-for-cell-therapy
#9
EDITORIAL
Capucine Guyot, Sophie Lerouge
No abstract text is available yet for this article.
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29682318/-rosmarinus-officinalis-l-an-update-review-of-its-phytochemistry-and-biological-activity
#10
REVIEW
Joana M Andrade, Célia Faustino, Catarina Garcia, Diogo Ladeiras, Catarina P Reis, Patrícia Rijo
The worldwide interest in the use of medicinal plants has been growing, and its beneficial effects being rediscovered for the development of new drugs. Based on their vast ethnopharmacological applications, which inspired current research in drug discovery, natural products can provide new and important leads against various pharmacological targets. This work pioneers an extensive and an updated literature review on the current state of research on Rosmarinus officinalis L., elucidating which compounds and biological activities are the most relevant...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29682317/validation-of-quantitative-polymerase-chain-reaction-with-southern-blot-method-for-telomere-length-analysis
#11
Mohamad Tarik, Lakshmy Ramakrishnan, Harshpal S Sachdev, Nikhil Tandon, Ambuj Roy, Santosh K Bhargava, Ravindra M Pandey
Aim: Telomere length (TL) measurement by quantitative polymerase chain reaction (PCR) has been widely accepted, but limited information regarding its validation with a gold-standard technique is available. Materials & methods: We measured TL by Southern blot and monochrome multiplex quantitative PCR (MMqPCR) and validated the results of TL in leukocytes of 94 participants with mean age 43.2 years, BMI 19-41 (mean 27.8 ± 4.3) kg/m2 . Results: A significant positive correlation was observed between TL measured by MMqPCR and Southern blot assay (correlation coefficient r = +0...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29568570/opportunities-and-challenges-for-hybrid-immunoaffinity-lc-ms-approach-for-quantitative-analysis-of-protein-biomarkers
#12
EDITORIAL
Yue Zhao, Huidong Gu, Jianing Zeng
No abstract text is available yet for this article.
March 2018: Future Science OA
https://www.readbyqxmd.com/read/29568569/polysaccharide-mediated-synthesis-of-melanins-from-serotonin-and-other-5-hydroxy-indoles
#13
Koen Vercruysse, Astiney Clark, Noor Alatas, Dylan Brooks, Nafisa Hamza, Margaret Whalen
Aim: As a continuation of our research on the melanin formation from catecholamines, we studied the polysaccharide-mediated oxidation of serotonin and other 5-hydroxy indoles into melanin-like materials. As for the catecholamines, we observed that many polysaccharides promote the oxidation of such compounds, particularly in the presence of Cu2+ . Methodology: The reactions were monitored using reverse phase-HPLC and size-exclusion chromatography techniques. Melanin-like materials were purified through dialysis and characterized using UV-Vis and Fourier transform IR spectroscopic techniques...
March 2018: Future Science OA
https://www.readbyqxmd.com/read/29568568/series-of-screening-compounds-with-high-hit-rates-for-the-exploration-of-multi-target-activities-and-assay-interference
#14
Dagmar Stumpfe, Erik Gilberg, Jürgen Bajorath
Aim: Generation of a database of analog series (ASs) with high assay hit rates for the exploration of assay interference and multi-target activities of compounds. Methodology: ASs were computationally extracted from extensively tested screening compounds with high hit rates. Data: A total of 6941 ASs were assembled comprising 14,646 unique compounds that were tested in a total of 1241 different assays covering 426 specified targets. These ASs were organized and prioritized on the basis of different activity and assay frequency criteria...
March 2018: Future Science OA
https://www.readbyqxmd.com/read/29568567/key-genes-and-regulatory-networks-involved-in-the-initiation-progression-and-invasion-of-colorectal-cancer
#15
Matin Asghari, Mohammad Foad Abazari, Hanieh Bokharaei, Maryam Nouri Aleagha, Vahdat Poortahmasebi, Hassan Askari, Sepehr Torabinejad, Abbas Ardalan, Navid Negaresh, Atousa Ataei, Parisa Pazooki, Mansour Poorebrahim
Aim: Until now, identification of drug targets for treatment of patients with specific stages of colorectal cancer (CRC) has remained a challenging field of research. Herein, we aimed to identify the key genes and regulatory networks involved in each stage of CRC. Results: The results of gene expression profiles were integrated with protein-protein interaction networks, and topologically analyzed. The most important regulatory genes (e.g., CDK1 , UBC , ESR1 and ATXN1 ) and signaling pathways (e...
March 2018: Future Science OA
https://www.readbyqxmd.com/read/29568566/could-dietary-glutamate-be-contributing-to-the-symptoms-of-obsessive-compulsive-disorder
#16
Kathleen F Holton, Elizabeth W Cotter
A 50-year-old man who had suffered from daily obsessive-compulsive disorder (OCD) symptoms for 39 years, in addition to fibromyalgia and irritable bowel syndrome symptoms, was enrolled in a randomized double-blind placebo-controlled clinical trial to test the effects of a low-glutamate diet on fibromyalgia/irritable bowel syndrome symptoms. After 1 month on the low-glutamate diet all of his symptoms remitted, including his OCD, which had previously been nonresponsive to pharmacological treatment. This case study is limited by self-report of symptoms; however, glutamatergic neurotransmission appears to be dysregulated in OCD, suggesting biological plausibility for this observation...
March 2018: Future Science OA
https://www.readbyqxmd.com/read/29568565/evaluation-of-cyp2c9-and-vkorc1-based-pharmacogenetic-algorithm-for-warfarin-dose-in-gaza-palestine
#17
Basim Mohammad Ayesh, Ahmed Shaker Abu Shaaban, Abdalla Asaf Abed
Aim: To evaluate applicability of CYP2C9*2 , *3 and VKORC1-1639G > A based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients. Patients & methods: Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD. Results: Frequency of CYP2C9*2 , *3 and VKORC1-1639G > A alleles is 13...
March 2018: Future Science OA
https://www.readbyqxmd.com/read/29568564/antibodies-synthetic-peptides-and-related-constructs-for-planetary-health-based-on-green-chemistry-in-the-anthropocene
#18
REVIEW
Salvador Eugenio C Caoili
The contemporary Anthropocene is characterized by rapidly evolving complex global challenges to planetary health vis-a-vis sustainable development, yet innovation is constrained under the prevailing precautionary regime that regulates technological change. Small-molecule xenobiotic drugs are amenable to efficient large-scale industrial synthesis; but their pharmacokinetics, pharmacodynamics, interactions and ultimate ecological impact are difficult to predict, raising concerns over initial testing and environmental contamination...
March 2018: Future Science OA
https://www.readbyqxmd.com/read/29568563/a-future-perspective-for-regenerative-medicine-understanding-the-concept-of-vibrational-medicine
#19
REVIEW
Kavita Beri
No abstract text is available yet for this article.
March 2018: Future Science OA
https://www.readbyqxmd.com/read/29568562/fascin-is-secreted-in-male-s-serum-results-of-a-pilot-study
#20
Daniel Porav-Hodade, Orsolya Martha, Daniel Balan, Sabin Tataru, Adina Hutanu, Anca Sin, Mihai Dorin Vartolomei
Aim: Fascin is a 55 kDa globular protein with an important role in cell migration. Aim of study was to investigate serum fascin in healthy males. Materials & methods: From 1 July 2016 to 31 December 2016, we collected serum from 46 males. Serum fascin level was performed using ELISA kit from USBiological (Salem, MA, USA). Results: Median age was 64 years. Mean fascin serum level was 9.84 ng/ml, mean prostate-specific antigen (PSA) was 2...
March 2018: Future Science OA
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