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Future Science OA

Azadeh Bashiri, Leila Shahmoradi, Hamid Beigy, Behrouz A Savareh, Masood Nosratabadi, Sharareh R N Kalhori, Marjan Ghazisaeedi
Aim: Quantitative EEG gives valuable information in the clinical evaluation of psychological disorders. The purpose of the present study is to identify the most prominent features of quantitative electroencephalography (QEEG) that affect attention and response control parameters in children with attention deficit hyperactivity disorder. Methods: The QEEG features and the Integrated Visual and Auditory-Continuous Performance Test ( IVA-CPT) of 95 attention deficit hyperactivity disorder subjects were preprocessed by Independent Evaluation Criterion for Binary Classification...
June 2018: Future Science OA
(no author information available yet)
[This corrects the article DOI: 10.4155/fsoa-2017-0077.].
June 2018: Future Science OA
(no author information available yet)
[This corrects the article DOI: 10.4155/fsoa-2017-0101.].
June 2018: Future Science OA
Andy Zx Zhu
Significant scientific advances in biomedical research have expanded our knowledge of the molecular basis of carcinogenesis, mechanisms of cancer growth, and the importance of the cancer immunity cycle. However, despite scientific advances in the understanding of cancer biology, the success rate of oncology drug development remains the lowest among all therapeutic areas. In this review, some of the key translational drug development objectives in oncology will be outlined. The literature evidence of how mathematical modeling could be used to build a unifying framework to answer these questions will be summarized with recommendations on the strategies for building such a mathematical framework to facilitate the prediction of clinical efficacy and toxicity of investigational antineoplastic agents...
June 2018: Future Science OA
Liu Ying-Ying, Yu Tian-Jian, Liu Guang-Yu
Aim: To investigate the benefits of axillary dissection in patients with micrometastases. Methods: A review of data from the Surveillance, Epidemiology, and End Results database was performed from 2004 to 2013. Kaplan-Meier curves, Cox regression models, and propensity score matching were utilized to comprehensively evaluate the cohort. Results: Multivariate analysis after propensity score matching showed that patients with one to two micrometastases did not substantially benefit from axillary lymph node dissection in breast cancer-specific survival (p = 0...
June 2018: Future Science OA
Vikramshankar Kamakoti, David Kinnamon, Kang Hyeok Choi, Badrinath Jagannath, Shalini Prasad
Aim: An electrochemical urine dipstick probe biosensor has been demonstrated using molybdenum electrodes on nanoporous polyamide substrate for the quantitative detection of two inflammatory protein biomarkers, CRP and IL-6. Materials & methods: The electrode interface was characterized using ζ-potential and Fourier transform infrared spectroscopy. Detection of biomarkers was demonstrated by measuring impedance changes associated with the dose concentrations of the two biomarkers...
June 2018: Future Science OA
Kenneth Lundstrom
Drugs and vaccines based on mRNA and RNA viruses show great potential and direct translation in the cytoplasm eliminates chromosomal integration. Limitations are associated with delivery and stability issues related to RNA degradation. Clinical trials on RNA-based drugs have been conducted in various disease areas. Likewise, RNA-based vaccines for viral infections and various cancers have been subjected to preclinical and clinical studies. RNA delivery and stability improvements include RNA structure modifications, targeting dendritic cells and employing self-amplifying RNA...
June 2018: Future Science OA
Svenja Dieffenbacher, Stefanie Zschäbitz, Luisa Hofer, Gencay Hatiboglu, Weibin Hou, Markus Hohenfellner, Stefan Duensing, Holger Sültmann, Sascha Pahernik, Carsten Grüllich
Aim: Targeted therapies have substantially improved the survival of patients with metastatic clear cell renal cell cancer. No prognostic or predictive biomarkers are available. Comprehensive genetic profiling offers the opportunity to define prognostic and predictive signatures aiming at a more personalized approach to treatment. Methods: In this prospectively conducted cohort study, tumor tissue and liquid biopsies are sampled at baseline and upon first and second progression under systemic treatment...
June 2018: Future Science OA
Feifei Pu, Fengxia Chen, Zhicai Zhang, Jing Feng, Ping Xia
Aim: Variants of TIM-3/HAVCR2 3'UTR miRNA binding sites are significantly associated with cancer; however, roles in post-transcriptional regulation have not been elucidated. Methods: The regulatory and coding region single nucleotide polymorphisms (SNPs) of TIM-3/HAVCR2 were identified using an online database. Single nucleotide polymorphism Function Prediction was used to predict potential functional relevance of miRNA binding sites. Results: The analysis indicated rs9313439, rs4704846, rs3087616 and rs1036199 affect possible miRNA binding sites in TIM-3/HAVCR2 3'UTR...
June 2018: Future Science OA
Kun Zhang, Shenghao Zhao, Wusheng Kan, Jun Xiao, Feifei Pu, Kun Li
Aim: To compare efficacy and safety of anticoagulants apixaban and rivaroxaban after lumbar spine surgery retrospectively. Methods: In this study comprising 480 patients, lower-limb swelling, deep venous thrombosis, pulmonary embolism, blood loss, ecchymosis and D-dimer changes were observed. Results: The changes in perimeter of the legs were tested, and significant differences were noted 10 cm above the patella, but no significant differences 10 cm below the patella...
June 2018: Future Science OA
Alastair J Moss, Stuart Hutchison, Marc R Dweck
No abstract text is available yet for this article.
June 2018: Future Science OA
John Osei Sekyere
Aim: Multidrug-resistant enterobacteria are highly associated with invasive devices and intensive care units. Increasing resistance to carbapenems is leading to the use of older and neglected antibiotics such as nitrofurantoin (NFT). The genomics of NFT resistance was investigated. Results & conclusion: High-level resistance to NFT (minimum inhibitory concentration ≥128-512 mg/l) was recorded in 31/36 isolates (89.6%), many of which were from intensive care units (n = 20), urine (n = 17) or invasive procedures (n = 10)...
June 2018: Future Science OA
Sonia Khier, Laura Lohan
Circulating cell-free DNA is considered as one of the major breakthroughs in the field of innovative diagnosis, used as a liquid biopsy. The kinetic parameters of a biomarker are mandatory to assess its usefulness as a diagnostic tool. Obtaining precise mathematical values for the kinetic parameters (e.g., half-life) is then crucial because it could be used for therapeutic monitoring as a prognostic factor. However, little is known about the intrinsic properties of circulating cell-free DNA, more especially, its kinetic properties within the organism...
April 2018: Future Science OA
Nina J Karlin, Shailja B Amin, Heidi E Kosiorek, Matthew R Buras, Patricia M Verona, Curtiss B Cook
Aim: We aimed to determine the effect of diabetes mellitus (DM) on survival in pancreatic cancer and effects of pancreatic cancer on glycemic control in DM. Materials & methods: Patients with pancreatic cancer from 2007 to 2015, with and without DM, were matched 1:1. We compared characteristics between the groups and assessed 2-year survival with Kaplan-Meier analysis. Results: In patients with DM, hemoglobin A1c decreased significantly over time (p = 0...
April 2018: Future Science OA
Junaid Ali, Qasim A Rafiq, Elizabeth Ratcliffe
Since the discovery of antibiotics by Sir Alexander Fleming they have been used throughout medicine and play a vital role in combating microorganisms. However, with their vast use, development of resistance has become more prevalent and their use is currently under threat. Antibiotic resistance poses a global threat to human and animal health, with many bacterial species having developed some form of resistance and in some cases within a year of first exposure to antimicrobial agents. This review aims to examine some of the mechanisms behind resistance...
April 2018: Future Science OA
Enrique R Soriano, Analia Dellepiane, Gabriela Salvatierra, Cristian Alejandro Benítez, Rodrigo Garcia Salinas, Carlos Baruzzo
Aim: To determine the efficacy and safety of certolizumab pegol for the treatment of rheumatoid arthritis in a real-world setting. Materials & methods: Patients with moderate-to-severe rheumatoid arthritis who initiated therapy with certolizumab were followed for 12 weeks. Response was assessed with Disease Activity Score of 28 joints, European Ligue Against Rheumatism criteria and Simplified Disease Activity Index. Predictors of response were analyzed with binary logistic regression models...
April 2018: Future Science OA
Ruud Hp Wilbers, Lotte B Westerhof, Debbie R van Raaij, Jaap Bakker, Geert Smant, Arjen Schots
Aim: Treatment of inflammatory disorders relies on the intervention in immune responses thereby restoring homeostasis. IL-10 is a cytokine with therapeutic potential, but until now has not been as successful as previously anticipated. A reason for this may be that IL-10 responsiveness depends on the environment of the inflamed tissue. In this study we investigated whether GM-CSF is able to influence IL-10-mediated responses. Methodology: Dendritic cells and macrophages were differentiated from mouse bone marrow and treated or depleted from GM-CSF prior to analyze their response to IL-10...
April 2018: Future Science OA
Dilyana Dimova, Jürgen Bajorath
Aim: Providing a large and freely available in silico collection of analog series-based (ASB) scaffolds for computational design and medicinal chemistry applications. Methodology: Using a recently introduced computational method, ASB scaffolds with single and multiple substitution sites were systematically isolated from publicly available active compounds. Data: A total of 23,791 unique ASB scaffolds are made available in an organized and machine-readable form as an open access deposition...
April 2018: Future Science OA
Srdjan Saso, Neil T Clancy, Benjamin P Jones, Timothy Bracewell-Milnes, Maya Al-Memar, Eleanor M Cannon, Simran Ahluwalia, Joseph Yazbek, Meen-Yau Thum, Tom Bourne, Daniel S Elson, James Richard Smith, Sadaf Ghaem-Maghami
Aim: Uterine transplantation (UTx) has been proposed as a treatment for permanent absolute uterine factor infertility. The study aims were to compare pulse oximetry and multispectral imaging (MSI), for intraoperative tracking of uterine oxygen saturation in animal UTx models (rabbit and sheep). Results/methodology: Imaging results confirmed the re-establishment of adequate perfusion in the transplanted organ after surgery. Comparison of oxygen saturation   values between the pre-UTx donor and post-UTx recipient, and pre-UTx and post-UTx recipient reveals a statistically significant decrease in saturation levels post-UTx...
April 2018: Future Science OA
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