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Future Science OA

Srdjan Saso, Maria Tziraki, Neil T Clancy, Lipei Song, Timothy Bracewell-Milnes, Benjamin P Jones, Maya Al-Memar, Joseph Yazbek, Meen-Yau Thum, Ahmad Sayasneh, Tom Bourne, James Richard Smith, Daniel S Elson, Sadaf Ghaem-Maghami
Aim: Uterine transplantation (UTx) is proposed for treatment of uterine factor infertility. Our aim was to assess whether Endoscopic Laser Speckle Contrast Analysis (eLASCA) could evaluate pelvic blood flow at anastomotic sites required for sheep and rabbit UTx. Results/methodology: eLASCA detected blood flow in rabbit UTx #7 and #9. In sheep UTx #2, #3 and #5, the results allowed us to conclude that blood flow was present in the uterine graft following transplantation; and post-UTx, the animal had heart and respiratory rates, and oxygen saturation compatible with a normal hemodynamic status...
July 2018: Future Science OA
Arun R Nelakurthi, Angela M Pinto, Curtiss B Cook, Lynne Jones, Mary Boyle, Jieping Ye, Theodoros Lappas, Jingrui He
Aim: To evaluate the use of social media of individuals with diabetes mellitus (DM). Materials & methods: Both web-based and in-clinic surveys were collected from individuals with DM. Descriptive and correlation analyses were employed to evaluate respondents' diabetes-specific social networking site behaviors. Results: Forty-five patients with DM completed the web-based survey and 167, the clinic-based survey, of whom only 40 visited diabetes-specific social networking sites...
July 2018: Future Science OA
Aaron Galaznik, Rachel Huelin, Michael Stokes, Yelan Guo, Meredith Hoog, Tarun Bhagnani, Jill Bell, Yaping Shou
To identify real-world evidence on outcomes from therapies for relapsed/refractory diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), we systematically reviewed literature in Medline/Embase for DLBCL/FL-related articles on real-world results published during January 2012-May 2016. Among 33 included articles, therapies included stem cell transplant (SCT) and chemotherapy, including experimental regimens. The highest overall survival rates were observed for SCT, long considered an optimal strategy following initial relapse...
July 2018: Future Science OA
Purva Mathur, Balaji Veeraraghavan, Naveen Kumar Devanga Ragupathi, Francis Yesurajan Inbanathan, Surbhi Khurana, Nidhi Bhardwaj, Subodh Kumar, Sushma Sagar, Amit Gupta
Aim: To investigate antimicrobial resistance mechanisms in a cluster of colistin-resistant Klebsiella pneumoniae . Methods: Antimicrobial susceptibility was tested by disk diffusion and broth microdilution. Whole-genome sequencing and genome analysis were performed. Results: The eight colistin-resistant K. pneumoniae isolates belonged to three different clones (ST11, 14 and 231). The eptA and arnT genes from lipid modification pathway had novel (R157S in arnT and Q319R in eptA ) and rare mutations (V39L, R152H, S260L and A279G in eptA )...
July 2018: Future Science OA
Sudip Mukherjee
No abstract text is available yet for this article.
July 2018: Future Science OA
Jon P Day, Ellanor Whiteley, Michael Freeley, Aideen Long, Beatrice Malacrida, Patrick Kiely, George S Baillie
Aim: RACK1 is a multifunctional scaffolding protein that is expressed in many cellular compartments, orchestrating a number of signaling processes. RACK1 acts as a signaling hub to localize active enzymes to discrete locations; therefore tight control of RACK1 is vital to cellular homeostasis. Our aim was to identify the mechanisms responsible for RACK1 turnover and show that degradation is directed by the ubiquitin proteasome system. Results: Using siRNA screening, we identified RAB40C as the ubiquitin E3 ligase responsible for ubiquitination of RACK1, and that the action of RAB40C in controlling RACK1 levels is crucial to both cancer cell growth and migration of T cells...
July 2018: Future Science OA
Marina A Malikova
No abstract text is available yet for this article.
July 2018: Future Science OA
Anne Weber-Ouellette, Mélanie Busby, Isabelle Plante
The epithelium's functional unit is the bilayered acinus, made of a layer of luminal cells, surrounded by a layer of basal cells mainly composed of myoepithelial cells. Aim: The aim of this study was to develop a reproducible and manipulable 3D co-culture model of the bilayered acinus in vitro to study the interactions between the two layers. Materials & methods: Two different combinations of cell lines were co-cultured in Matrigel: SCp2 and SCg6 mice cells, or MCF-12A and Hs 578Bst human cell lines...
July 2018: Future Science OA
Yuan Fang
Circular RNAs (circRNAs) are a large class of noncoding RNAs characterized with closed loop structures without 3' and 5' polar ends. They can roughly be divided into exonic circRNAs, exon-intron circRNAs and circular intronic RNAs. CircRNAs are characterized with stability, prevalence, specificity and conservation, which arouse great interest in circRNAs as disease biomarkers. Their abilities to sponge to miRNAs, cis-regulate parent genes, bind to proteins and encode proteins endow circRNAs a critical role of regulation in eukaryotic cells...
July 2018: Future Science OA
George Fotakopoulos, Demosthenes Makris, Polikceni Kotlia, Effie Kapsalaki, John Papanikolaou, Iordanis Georgiadis, Epaminondas Zakynthinos, Kostas Fountas
Early detection and diagnosis of cerebral vasospasm in subarachnoid hemorrhage may be challenging both on clinical and radiographic grounds. In this respect we conducted a pilot study in order to assess the feasibility of the technique in the everyday setting of a tertiary hospital and to evaluate the diagnostic performance of different diagnostic computed tomography perfusion aspects in diagnosing the clinical outcome of patients with subarachnoid hemorrhage. Receiver-operating characteristic analysis showed that a cerebral blood flow value of <24...
July 2018: Future Science OA
Balaji Veeraraghavan, Agila K Pragasam, Yamuna D Bakthavatchalam, Ravikar Ralph
Multidrug-resistant Salmonella enterica subsp. enterica serovar Typhi (resistant to ampicillin, chloramphenicol and cotrimoxazole), was significantly reduced with the increased usage of fluoroquinolones and azithromycin. This has led to declining multidrug resistance rates in India with increasing ciprofloxacin nonsusceptibility rates and clinical failures due to azithromycin. However, for the available agents such as ceftriaxone, azithromycin and fluoroquinolones, the dose and duration for treatment is undefined...
July 2018: Future Science OA
Andrea Salzano, Antonio Cittadini, Eduardo Bossone, Toru Suzuki, Liam M Heaney
No abstract text is available yet for this article.
July 2018: Future Science OA
Liene Bervoets, Guy Massa, Wanda Guedens, Gunter Reekmans, Jean-Paul Noben, Peter Adriaensens
Aim: To identify the plasma metabolic profile associated with childhood obesity and its metabolic phenotypes. Materials & methods: The plasma metabolic profile of 65 obese and 37 normal-weight children was obtained using proton NMR spectroscopy. NMR spectra were rationally divided into 110 integration regions, which reflect relative metabolite concentrations, and were used as statistical variables. Results: Obese children show increased levels of lipids, N-acetyl glycoproteins, and lactate, and decreased levels of several amino acids, α-ketoglutarate, glucose, citrate, and cholinated phospholipids as compared with normal-weight children...
July 2018: Future Science OA
Zhen Zeng, Tommaso Raffaello, Meng-Xia Liu, Fred O Asiegbu
The successful implementation of next-generation sequencing techniques in plant and woody tissues depends on the quality of initial starting material. This study demonstrated the use of a modified protocol that enabled the simultaneous extraction of both genomic DNA and total RNA from recalcitrant woody material. The genetic material obtained by this protocol is of high quality and can be directly used in downstream analysis (e.g., next-generation sequencing). This protocol is particularly useful not only when the initial plant material is limited but also when genomic DNA features (e...
July 2018: Future Science OA
Janice A Nagy, Kush Kapur, Rebecca S Taylor, Benjamin Sanchez, Seward B Rutkove
Aim: We sought to determine the sensitivity of electrical impedance myography (EIM) to myofiber hypertrophy induced by treatment with various doses of ActRIIB-mFc, an inhibitor of myostatin signaling. Methods: Wild-type C57BL/6 J mice (n = 40, male) were treated with three different doses of ActRIIB-mFc (i.e., RAP-031) or vehicle twice weekly for 5 weeks. End point assessments included gastrocnemius EIM, force measurements, muscle mass and myofiber size quantification...
July 2018: Future Science OA
Livio Pagano, Susan Mayor
Trends in Medical Mycology (TIMM) is the biennial meeting of the Infectious Disease Group of the European Organisation for Research and Treatment of Cancer (EORTC) and the European Confederation of Medical Mycology (ECMM). It brings together clinicians and researchers from across the world to share the latest R&Ds in medical mycology. Despite advances in treatment, invasive fungal infections remain a major cause of morbidity and mortality in certain high-risk groups of patients, particularly in immunocompromised patients, including those undergoing solid organ transplantation and those with acute leukemia...
July 2018: Future Science OA
Nívea P Sá, Caroline M Lima, Julliana R A Dos Santos, Marliete C Costa, Patrícia P de Barros, Juliana C Junqueira, Jéssica A Vaz, Renata B Oliveira, Beth B Fuchs, Eleftherios Mylonakis, Carlos A Rosa, Daniel A Santos, Susana Johann
Aim: In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against Cryptococcus spp. and Candida albicans . Methods: The ability of CHT to act in biofilm and also to interfere with C. albicans adhesion was evaluated, as well as the efficiency of the CHT in cryptococcosis and candidiasis invertebrate and murine models. Results & conclusion: In the present work we verified that CHT is found to inhibit Cryptococcus and C...
July 2018: Future Science OA
Tomoaki Tanaka, Akinori Minami, Kouichiro Tashiro, Naomasa Yoshida, Akira Tohda, Yasuo Yamakoshi, Ryoji Yasumoto, Shozo Sugita, Tatsuya Nakatani
Aim: To investigate whether urine levels of miRNAs that regulate the function of endothelial cells are associated with effectiveness in benign prostatic hyperplasia (BPH) patients treated with a phosphodiesterase type 5 inhibitor, tadalafil. Patients & methods: We measured urine levels of three miRNAs (miR-21-5p, miR-126-5p & miR-155-5p) in 55 BPH patients before and after tadalafil administration to understand its effectiveness. Results: Baseline urine miR-21-5p level was an independent predictor of response to tadalafil in multivariate regression analysis (odds ratio: 0...
July 2018: Future Science OA
Kavita Beri
Recent advances in our understanding of the function of the skin and its microbiome have shown that there is a strong symbiotic relationship between the microbiota of the skin and its host immune functions. The dysbiosis or imbalance of the microbiome and other factors that have an influence on the surface microbiota can influence keratinocyte regulation and homeostasis as well as the skin barrier function. In this perspective paper, we review the evidence that connects the skin's microbiome and the barrier function of the epidermis and explore the future potential for applying this unique dialogue in developing innovative cosmetics and transdermal drugs for wellbeing and beauty...
July 2018: Future Science OA
Azadeh Bashiri, Leila Shahmoradi, Hamid Beigy, Behrouz A Savareh, Masood Nosratabadi, Sharareh R N Kalhori, Marjan Ghazisaeedi
Aim: Quantitative EEG gives valuable information in the clinical evaluation of psychological disorders. The purpose of the present study is to identify the most prominent features of quantitative electroencephalography (QEEG) that affect attention and response control parameters in children with attention deficit hyperactivity disorder. Methods: The QEEG features and the Integrated Visual and Auditory-Continuous Performance Test ( IVA-CPT) of 95 attention deficit hyperactivity disorder subjects were preprocessed by Independent Evaluation Criterion for Binary Classification...
June 2018: Future Science OA
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