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https://www.readbyqxmd.com/read/30416748/profiling-and-bioinformatics-analyses-of-differential-circular-rna-expression-in-prostate-cancer-cells
#1
Chunlei Zhang, Jun Xiong, Qi Yang, Ye Wang, Haoqing Shi, Qinqin Tian, Hai Huang, Depei Kong, Jianmin Lv, Dan Liu, Xu Gao, Xiaoyuan Zi, Yinghao Sun
Aim: There is little knowledge about the expression profile and function of circular RNAs (circRNAs) in prostate cancer (PCa). Methods: The expression profiles of circRNAs in RWPE-1, 22RV1 and PC3 cells were explored via high-throughput circRNAs sequencing and validated by real-time qPCR. The roles of differentially expressed circRNAs were evaluated by bioinformatics analyses. Results: Altogether 9545 circRNAs were identified and hundreds of differentially expressed circRNAs were recognized...
October 2018: Future Science OA
https://www.readbyqxmd.com/read/30416747/gram-negative-infections-evolving-treatments-with-expanding-options
#2
Maria Virginia Villegas, Sue Lyon
Antibiotic resistance was a major topic of interest for the nearly 13,000 physicians, microbiologists and scientists who attended European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) 2018. Much discussion centered round the potential benefits of novel antibiotics that are either already approved or under investigation in the treatment of infections caused by resistant Gram-negative pathogens. There was also general acceptance of the importance of ensuring that antibiotic stewardship is implemented in every ward throughout every hospital to ensure that these novel drugs are used appropriately and to combat the development of resistance...
October 2018: Future Science OA
https://www.readbyqxmd.com/read/30416746/recent-advances-in-the-discovery-of-small-molecule-inhibitors-of-hiv-1-integrase
#3
REVIEW
Eungi Choi, Jayapal Reddy Mallareddy, Dai Lu, Srikanth Kolluru
AIDS caused by the infection of HIV is a prevalent problem today. Rapid development of drug resistance to existing drug classes has called for the discovery of new targets. Within the three major enzymes (i.e., HIV-1 protease, HIV-1 reverse transcriptase and HIV-1 integrase [IN]) of the viral replication cycle, HIV-1 IN has been of particular interest due to the absence of human cellular homolog. HIV-1 IN catalyzes the integration of viral genetic material with the host genome, a key step in the viral replication process...
October 2018: Future Science OA
https://www.readbyqxmd.com/read/30416745/recovery-of-whole-mitochondrial-genome-from-compromised-samples-via-multiplex-pcr-and-massively-parallel-sequencing
#4
Maureen P Hickman, Kelly S Grisedale, Brittania J Bintz, Erin S Burnside, Erin K Hanson, Jack Ballantyne, Mark R Wilson
In forensic casework, compromised samples often possess limited or degraded nuclear DNA, rendering mitochondrial DNA a more feasible option for forensic DNA analyses. The emergence of massively parallel sequencing (MPS) has enabled the recovery of extensive sequence information from very low quantities of DNA. We have developed a multiplex PCR method that amplifies the complete mitochondrial genome in a range of forensically relevant samples including single cells, cremated remains, bone, maggot and hairs isolated from dust bunnies...
October 2018: Future Science OA
https://www.readbyqxmd.com/read/30416744/survival-and-glycemic-control-in-patients-with-colorectal-cancer-and-diabetes-mellitus
#5
Nina J Karlin, Shailja B Amin, Heidi E Kosiorek, Matthew R Buras, Patricia M Verona, Curtiss B Cook
Aim: The impact of diabetes mellitus (DM) on survival in patients with colorectal cancer and the impact of colorectal cancer on glycemic control were examined. Materials & methods: Patients with colorectal cancer with and without DM were matched 1:1 (2007-2015). Characteristics were compared between the two groups and survival assessed with the Kaplan-Meier method. Mixed models compared hemoglobin A1c and glucose levels over time. Results: In both groups, glucose values decreased during the year following cancer diagnosis (p < 0...
October 2018: Future Science OA
https://www.readbyqxmd.com/read/30416743/analysis-of-nutrition-clinical-studies-involving-children-in-the-middle-east-and-globally
#6
Fatih Ozdener, Feza Kirbiyik, Ali Evrim Dogan
Aim: To assess pediatric clinical nutrition research by analyzing clinical studies in the Middle East (ME) and globally. Methods: Using ClinicalTrials.gov, the numbers of clinical studies in the ME and globally were analyzed. Results: The majority of clinical nutrition trials are in North America and Europe. The ME accounts for 4% of all nutrition trials. The majority of pediatric nutrition studies in the ME are in the later phases or are observational and/or epidemiological studies with a focus on poor nutrition or nutrition disorders...
October 2018: Future Science OA
https://www.readbyqxmd.com/read/30416742/genetic-polymorphisms-of-matrix-metalloproteinases-1-3-and-their-inhibitor-are-not-associated-with-premature-labor
#7
Konstantinos Lathouras, Srdjan Saso, Menelaos Tzafetas, Kallirroi Kalinderi, Styliani Fidani, Vassiliki Zournatzi, Maria Kyrgiou, Christina Fotopoulou, Sadaf Ghaem-Maghami, Ioannis Tzafetas
Aim: Extracellular matrix metalloproteinases (MMPs) and their inhibitors (tissue inhibitors of metalloproteinases [TIMPs]) are involved in the breakdown of fetal membranes before delivery. Our aim was to investigate the occurrence of any polymorphism on genes coding for MMPs 1-3 and TIMP 2 in preterm laboring patients as a potential source of this phenomenon. This question has not been studied before. Methodology & results: A prospective population study was performed in a Greek university hospital...
October 2018: Future Science OA
https://www.readbyqxmd.com/read/30416741/functional-foods-and-cancer-on-pinterest-and-pubmed-myths-and-science
#8
Graça Justo, Eloy Macchiute de Oliveira, Claudia Jurberg
Aim: This article examines whether social media postings dealing with cancer and so-called 'functional foods' simply reflect a fashionable subject or are based on scientific evidence. Methods: The first step consisted of an analysis of a sample of Pins published on Pinterest. The second consisted of an analysis to determine whether the content of the Pins was based on scientific research. Results: From a set of 507 Pins on cancer, we found 204 that also dealt with food...
October 2018: Future Science OA
https://www.readbyqxmd.com/read/30271620/rodentsql-a-software-suite-for-colony-management-of-animal-protocols
#9
Shrikant Pawar, Harshul Batra
Aim: Animal experiments tend to generate large-scale data. Some existing tools like Microsoft Excel and colony management cloud-based tools are either cumbersome or expensive. There is a need for an inexpensive and uncomplicated colony management software with specific individual database solutions. Methods: We have developed a database application named RodentSQL to meet most of the requirements of such animal colony management programs. Results: We present a user-friendly secure system for managing records of phenotype, genotype and metadata for comprehensive data analysis and mining...
September 2018: Future Science OA
https://www.readbyqxmd.com/read/30271619/the-world-could-end-cervical-cancer-if-it-tried-an-interview-with-dr-shobha-s-krishnan
#10
Shobha S Krishnan
Shobha S Krishnan is the Founder and President of the Global Initiative Against HPV and Cervical Cancer (GIAHC). She is a board-certified family physician and gynecologist and has been involved in the areas of primary care and women's health for over 30 years. She has extensive experience both nationally and internationally in the field of HPV and HPV-related diseases. Her vast experience in this field has given her a unique perspective on various issues related to HPV and its disease consequences. She is the author of the national and international award-winning book, The HPV Vaccine Controversy: Sex, Cancer, God and Politics (Praeger, 2008)...
September 2018: Future Science OA
https://www.readbyqxmd.com/read/30271618/glomerular-hyperfiltration-and-%C3%AE-2-microglobulin-as-biomarkers-of-incipient-renal-dysfunction-in-cancer-survivors
#11
Fernanda R Tibúrcio, Karla E de S Rodrigues, André R Belisário, Ana Cristina Simões-E-Silva
Herein, we aimed to evaluate the occurrence of impaired renal function after cancer treatment with potentially nephrotoxic chemotherapy in children. A cross-sectional study was performed in 41 cancer survivors after chemotherapy with potentially nephrotoxic drugs. 26 (63.4%) children were detected with glomerular hyperfiltration, and urinary levels of β-2 microglobulin (B2MG) were higher than reference range in all patients. Levels of B2MG were positively correlated with plasma creatinine and negatively correlated with glomerular filtration rate...
September 2018: Future Science OA
https://www.readbyqxmd.com/read/30271617/quantitation-of-paracetamol-by-liquid-chromatography-mass-spectrometry-in-human-plasma-in-support-of-clinical-trial
#12
Richard Kin-Ting Kam, Michael Ho-Ming Chan, Hiu-Ting Wong, Aniruddha Ghose, Arjen M Dondorp, Katherine Plewes, Joel Tarning
Aim: Paracetamol is a well-tolerated antipyretic widely used in severe malaria management. The study aimed to develop and validate a rapid LC-MS/MS assay to quantify paracetamol in plasma from patients with severe malaria. Materials & methods: Plasma sample was precipitated by organic solvent containing isotope-labeled paracetamol internal standard. Supernatant was isolated, diluted with water, followed by LC-MS/MS analysis. Results: Plasma samples were extracted and assayed in less than 5...
September 2018: Future Science OA
https://www.readbyqxmd.com/read/30271616/evaluation-of-two-eco-friendly-neutralizers-for-a-spectrum-of-tissue-fixatives-for-biomedical-applications
#13
Roshini Prakash, Stanley Thomas Carmichael
Formaldehyde is a widely used aldehyde in biomedical applications, including tissue fixation. It is this same fixative property that can result in toxicity if aldehydes are improperly discarded. A proper neutralization of aldehyde waste products can address this, thereby reducing both health and environmental toxicity concerns. In this study two commercially available products designed to neutralize formaldehyde were evaluated, including neutralization of laboratory derived tissue fixative waste. The primary selection criteria for inclusion in the study were: their ease of use (based on product instructions); the two products assert high levels of formaldehyde neutralization (below 20 ppm) relative to other neutralizing products and their lack of generation of polymeric residues that can clog drains...
September 2018: Future Science OA
https://www.readbyqxmd.com/read/30271615/computationally-derived-compound-profiling-matrices
#14
EDITORIAL
Martin Vogt, Swarit Jasial, Jürgen Bajorath
Aim: Screening of compounds against panels of targets yields profiling matrices. Such matrices are excellent test cases for the analysis and prediction of ligand-target interactions. We made three matrices freely available that were extracted from public screening data. Methodology: A new algorithm was used to derive complete profiling matrices from assay data. Data: Two profiling matrices were derived from confirmatory assays containing 53 different targets and 109,925 and 143,310 distinct compounds, respectively...
September 2018: Future Science OA
https://www.readbyqxmd.com/read/30271614/analysis-of-bone-healing-with-a-novel-bone-wax-substitute-compared-with-bone-wax-in-a-porcine-bone-defect-model
#15
Tristan Tham, Keith Roberts, John Shanahan, John Burban, Peter Costantino
Aim: This pilot study describes a novel composite of hydroxyapatite and biodegradable polylactic acid with wax-like handling properties (BoneSeal® ). The goal was to compare quantitative measures of bone healing between BoneSeal versus Bone wax. Materials & methods: BoneSeal and Bone wax were introduced into separate defects of a single porcine specimen. After 6 weeks, the defect sites were harvested for analysis. Results: Both groups had similar hemostatic action...
September 2018: Future Science OA
https://www.readbyqxmd.com/read/30271613/histone-deacetylases-as-targets-for-antitrypanosomal-drugs
#16
REVIEW
Aline A Zuma, Wanderley de Souza
Parasitic protozoa comprise several species that are causative agents of important diseases. These diseases are distributed throughout the world and include leishmaniasis, Chagas disease and sleeping sickness, malaria and toxoplasmosis. Treatment is based on drugs that were developed many years ago, which have side effects and produce resistant parasites. One approach for the development of new drugs is the identification of new molecular targets. We summarize the data on histone deacetylases, a class of enzymes that act on histones, which are closely associated with DNA and its regulation...
September 2018: Future Science OA
https://www.readbyqxmd.com/read/30271612/foundations-of-data-driven-medicinal-chemistry
#17
EDITORIAL
Jürgen Bajorath
No abstract text is available yet for this article.
September 2018: Future Science OA
https://www.readbyqxmd.com/read/30112192/use-of-laser-speckle-contrast-analysis-during-pelvic-surgery-in-a-uterine-transplantation-model
#18
Srdjan Saso, Maria Tziraki, Neil T Clancy, Lipei Song, Timothy Bracewell-Milnes, Benjamin P Jones, Maya Al-Memar, Joseph Yazbek, Meen-Yau Thum, Ahmad Sayasneh, Tom Bourne, James Richard Smith, Daniel S Elson, Sadaf Ghaem-Maghami
Aim: Uterine transplantation (UTx) is proposed for treatment of uterine factor infertility. Our aim was to assess whether Endoscopic Laser Speckle Contrast Analysis (eLASCA) could evaluate pelvic blood flow at anastomotic sites required for sheep and rabbit UTx. Results/methodology: eLASCA detected blood flow in rabbit UTx #7 and #9. In sheep UTx #2, #3 and #5, the results allowed us to conclude that blood flow was present in the uterine graft following transplantation; and post-UTx, the animal had heart and respiratory rates, and oxygen saturation compatible with a normal hemodynamic status...
July 2018: Future Science OA
https://www.readbyqxmd.com/read/30112191/should-patients-with-diabetes-be-encouraged-to-integrate-social-media-into-their-care-plan
#19
Arun R Nelakurthi, Angela M Pinto, Curtiss B Cook, Lynne Jones, Mary Boyle, Jieping Ye, Theodoros Lappas, Jingrui He
Aim: To evaluate the use of social media of individuals with diabetes mellitus (DM). Materials & methods: Both web-based and in-clinic surveys were collected from individuals with DM. Descriptive and correlation analyses were employed to evaluate respondents' diabetes-specific social networking site behaviors. Results: Forty-five patients with DM completed the web-based survey and 167, the clinic-based survey, of whom only 40 visited diabetes-specific social networking sites...
July 2018: Future Science OA
https://www.readbyqxmd.com/read/30112190/systematic-review-of-therapy-used-in-relapsed-or-refractory-diffuse-large-b-cell-lymphoma-and-follicular-lymphoma
#20
REVIEW
Aaron Galaznik, Rachel Huelin, Michael Stokes, Yelan Guo, Meredith Hoog, Tarun Bhagnani, Jill Bell, Yaping Shou
To identify real-world evidence on outcomes from therapies for relapsed/refractory diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), we systematically reviewed literature in Medline/Embase for DLBCL/FL-related articles on real-world results published during January 2012-May 2016. Among 33 included articles, therapies included stem cell transplant (SCT) and chemotherapy, including experimental regimens. The highest overall survival rates were observed for SCT, long considered an optimal strategy following initial relapse...
July 2018: Future Science OA
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