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Papillomavirus Research

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https://www.readbyqxmd.com/read/29665430/awareness-of-cervical-cancer-and-willingness-to-be-vaccinated-against-human-papillomavirus-in-mozambican-adolescent-girls
#1
Azucena Bardají, Carolina Mindu, Orvalho J Augusto, Aina Casellas, Olga Cambaco, Egas Simbine, Graça Matsinhe, Eusébio Macete, Clara Menéndez, Esperança Sevene, Khátia Munguambe
Sub-Saharan Africa concentrates the largest burden of cervical cancer worldwide. The introduction of the HPV vaccination in this region is urgent and strategic to meet global health targets. This was a cross-sectional study conducted in Mozambique prior to the first round of the HPV vaccine demonstration programme. It targeted girls aged 10-19 years old identified from schools and households. Face-to-face structured interviews were conducted. A total of 1,147 adolescents were enrolled in three selected districts of the country...
April 14, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29660489/prevalence-of-mucosal-and-cutaneous-human-papillomavirus-in-moroccan-breast-cancer
#2
Amal ElAmrani, Tarik Gheit, Mustapha Benhessou, Sandrine McKay-Chopin, Mohammed Attaleb, Souha Sahraoui, Mohammed El Mzibri, Marilys Corbex, Massimo Tommasino, Meriem Khyatti
BACKGROUND: Due to recent technical improvements and some encouraging new results, there has been a resurgence of interest in the possibility that a substantial proportion of breast cancers (BCs) may be caused by viral infections, including Human papillomavirus (HPV). The aim of this study was to determine the prevalence of mucosal and cutaneous HPV in tumours from Moroccan BC patients. MATERIALS AND METHODS: Frozen tumours from 76 BC cases and 12 controls were evaluated for the presence of 62 HPV-types using highly sensitive assays that combine multiplex polymerase chain reaction and bead-based Luminex technology...
April 13, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29649654/hpv-dna-methylation-at-the-early-promoter-and-e1-e2-integrity-a-comparison-between-hpv16-hpv18-and-hpv45-in-cervical-cancer
#3
Sérgio Menezes Amaro-Filho, Cláudia Bessa Pereira Chaves, Shayany Pinto Felix, Diogo Lisbôa Basto, Liz Maria de Almeida, Miguel Angelo Martins Moreira
OBJECTIVES: To compare and describe type-specific characteristics of HPV16, HPV18 and HPV45 in cervical cancer with respect to 3'LCR methylation and disruption of E1/E2. METHODS: The methylation level of 137 cervical cancer samples (70 with HPV16, 37 with HPV18, and 30 with HPV45) of Brazilian patients was analyzed by pyrosequencing. PCR amplifications were performed to characterize E1 and E2 disruption as an episomal surrogate. RESULTS: The 3'LCR of HPV16 showed a higher methylation at all CpG sites (7%, 9%, 11%, 10% and 10%) than homologous HPV18 regions (4%, 5%...
April 9, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29626643/patterns-of-repeated-anal-cytology-results-among-hiv-positive-and-hiv-negative-men-who-have-sex-with-men
#4
Hilary A Robbins, Dorothy J Wiley, Ken Ho, Michael Plankey, Susheel Reddy, Nancy Joste, Teresa M Darragh, Elizabeth C Breen, Stephen Young, Gypsyamber D'Souza
BACKGROUND: Men who have sex with men (MSM) are at increased risk for anal cancer. In cervical cancer screening, patterns of repeated cytology results are used to identify low- and high-risk women, but little is known about these patterns for anal cytology among MSM. METHODS: We analyzed Multicenter AIDS Cohort Study (MACS) data for MSM who were offered anal cytology testing annually (HIV-positive) or every 2 years (HIV-negative) for 4 years. RESULTS: Following an initial negative (normal) cytology, the frequency of a second negative cytology was lower among HIV-positive MSM with CD4≥500 (74%) or CD4<500 (68%) than HIV-negative MSM (83%) (p<0...
April 4, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29578098/influencers-and-preference-predictors-of-hpv-vaccine-uptake-among-us-male-and-female-young-adult-college-students
#5
A Scott LaJoie, Jelani C Kerr, Richard D Clover, Diane M Harper
OBJECTIVE: The purpose of the study was to assess the knowledge, attitudes and beliefs of male and female college students in Kentucky about HPV associated diseases and vaccines, and to determine which parameters predicted self-reported uptake of HPV vaccination. MATERIALS AND METHODS: A self-selected cross-sectional sample of college students completed an evidence-based online survey. RESULTS: Of approximately 1,200 potential respondents, 585 completed the survey...
March 22, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29578097/are-two-doses-of-human-papillomavirus-vaccine-sufficient-for-girls-aged-15-18-years-results-from-a-cohort-study-in-india
#6
Neerja Bhatla, Bhagwan M Nene, Smita Joshi, Pulikottil O Esmy, Usha Rani Reddy Poli, Geeta Joshi, Yogesh Verma, Eric Zomawia, Sharmila Pimple, Priya R Prabhu, Partha Basu, Richard Muwonge, Sanjay Hingmire, Catherine Sauvaget, Eric Lucas, Michael Pawlita, Tarik Gheit, Kasturi Jayant, Sylla G Malvi, Maqsood Siddiqi, Angelika Michel, Julia Butt, Subha Sankaran, Thiraviam Pillai Rameshwari Ammal Kannan, Rintu Varghese, Uma Divate, Martina Willhauck-Fleckenstein, Tim Waterboer, Martin Müller, Peter Sehr, Alka Kriplani, Gauravi Mishra, Radhika Jadhav, Ranjit Thorat, Massimo Tommasino, M Radhakrishna Pillai, Rengaswamy Sankaranarayanan
Extending two-dose recommendations of HPV vaccine to girls between 15-18 years will reduce program cost and improve compliance. Immunogenicity and vaccine targeted HPV infection outcomes were compared between 1795 girls aged 15-18 years receiving two (1-180 days) and 1515 girls of same age receiving three (1-60-180 days) doses. Immunogenicity outcomes in 15-18 year old two-dose recipients were also compared with the 10-14 year old three-dose (N=2833) and two-dose (N=3184) recipients. The 15-18 year old two-dose recipients had non-inferior L1-binding antibody titres at seven months against vaccine-targeted HPV types compared to three-dose recipients at 15-18 years and three-dose recipients at 10-14 years of age...
March 22, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29555602/contribution-of-human-papillomavirus-in-neuroendocrine-tumors-from-a-series-of-10-575-invasive-cervical-cancer-cases
#7
Maria Alejo, Laia Alemany, Omar Clavero, Beatriz Quiros, Susana Vighi, Muhieddine Seoud, Chou Cheng-Yang, Suzanne M Garland, Nuria Juanpere, Josep Lloreta, Sara Tous, Jo Ellen Klaustermeier, Wim Quint, F Xavier Bosch, Silvia de Sanjosé, Belen Lloveras
AIMS: Neuroendocrine tumors (NET) of the cervix are rare tumors with a very aggressive course. The human papillomavirus (HPV) has been linked to its etiology. The objective of this study is to describe HPV prevalence and genotype distribution of NET. METHODS AND RESULTS: Forty-nine tumors with histological neuroendocrine features were identified among 10,575 invasive cervical cancer (ICC) cases from an international study. HPV DNA detection was done using SPF10/DEIA /LiPA25 system...
March 16, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29555601/seroprevalence-of-hpv-6-11-16-and-18-and-correlates-of-exposure-in-unvaccinated-women-aged-16-64-years-in-puerto-rico
#8
A P Ortiz, G Tortolero-Luna, J Romaguera, C M Pérez, D González, C Muñoz, L González, E Marrero, E Suárez, J M Palesfky, G Panicker, E R Unger
BACKGROUND: To understand risk factors for HPV exposure in Puerto Rican women, we evaluated HPV 6, 11, 16, and 18 serology in women aged living in the San Juan metropolitan area. METHODS: As part of a cross-sectional study, a population-based sample of 524 HPV unvaccinated Hispanic women ages 16-64 years completed face-to-face and computer assisted interviews and provided blood and self-collected anal and cervical specimens. Serology used multiplex virus-like particle based-IgG ELISA and HPV DNA was detected with L1-consensus PCR...
March 16, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29555600/identifying-populations-most-susceptible-to-get-benefit-from-broadening-the-scope-for-prevention-of-cervical-cancer-example-from-uruguay
#9
Víctor-Guillermo Sequera, Marisa Mena, Malen Hollmann, Estefani Mani, Viviana Ramas, Sylvia Bonilla, Alicia Guerra, Fernando Borgia
OBJECTIVES: To identify factors associated with high-risk human papillomavirus (HPV) infection and high grade squamous intraepithelial lesion (HSIL) among a high-risk group of HPV-unvaccinated women in Montevideo. METHODS: Participants completed a questionnaire on socio-demographics, sexual behavior and gynecological history and received a gynecological examination. HPV DNA was detected by PCR using MY09/11 primers. Logistic regression analyses were performed to identify factors associated with high-risk HPV infection and HSIL...
March 16, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29555599/periodontitis-and-oral-human-papillomavirus-infection-among-hispanic-adults
#10
Ana Patricia Ortiz, Daisy González, José Vivaldi-Oliver, Maira Castañeda, Vivian Rivera, Elba Díaz, Hilmaris Centeno, Cristina Muñoz, Joel Palefsky, Kaumudi Joshipura, Cynthia M Pérez
INTRODUCTION: Research on the association between periodontitis and oral human papilloma virus (HPV) infection is inconsistent. The cross-sectional association of severe periodontitis with oral HPV infection was investigated in a sample of Hispanic adults. METHODS: Data from the 2014-2016 San Juan Overweight Adults Longitudinal Study (n=740) was analyzed. Periodontitis assessment and self-collection of oral HPV samples followed the National Health and Nutrition Examination Survey methodology...
March 16, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29524677/hpv-vaccination-in-male-physicians-a-survey-of-gynecologists-and-otolaryngology-surgeons-attitudes-towards-vaccination-in-themselves-and-their-patients
#11
Claire Stanley, Michael Secter, Sarah Chauvin, Amanda Selk
OBJECTIVE: Attitudes and barriers towards HPV vaccination were explored in a population of male surgeons in Gynecology and Otolaryngology in Ontario, Canada. MATERIALS/METHODS: An internet-based survey was distributed to male residents and physicians affiliated with the departments of Obstetrics and Gynecology, and Otolaryngology at six Ontario universities. The survey consisted of 16 questions (3 demographic, 3 workplace exposure, 6 regarding personal vaccination, and 3 regarding patient vaccination)...
March 7, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29524676/are-dental-providers-the-next-line-of-hpv-related-prevention-providers-perceived-role-and-needs
#12
Nolan Kline, Cheryl Vamos, Erika Thompson, Frank Catalanotto, John Petrila, Rita Debate, Stacey Griner, Coralia Vázquez-Otero, Laura Merrell, Ellen Daley
The rise in HPV-related oropharyngeal cancer incidence necessitates novel prevention efforts including multiple provider types. Although dental providers screen for HPV-related oropharyngeal cancers, little is known about their needs to advance "primordial prevention," or interventions at the earliest possible stage, to prevent HPV-related cancers. This study assessed dentists and dental hygienists' perceived roles and needs regarding HPV-related primordial prevention. We conducted a mixed-method study with data from focus groups with dentists (n=33) and dental hygienists (n=48) and surveys from both provider types (n=203) among providers from a diverse set of practice settings and geographic communities...
March 7, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29499389/ipvs-statement-moving-towards-elimination-of-cervical-cancer-as-a-public-health-problem
#13
EDITORIAL
S M Garland, A Giuliano, Jml Brotherton, A B Moscicki, M Stanley, A M Kaufmann, N Bhatla, R Sankaranarayanan, J M Palefsky, S de Sanjose
No abstract text is available yet for this article.
February 27, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29481964/no-association-between-hpv-vaccine-and-reported-post-vaccination-symptoms-in-japanese-young-women-results-of-the-nagoya-study
#14
Sadao Suzuki, Akihiro Hosono
Nagoya City introduced free HPV vaccination in 2010 and in April 2013 the Ministry of Health, Labour and Welfare included the HPV vaccine in the National Immunization Program. However, in June 2013, the Ministry suspended proactive recommendation of the vaccine after unconfirmed reports of adverse events. To investigate any potential association between the vaccine and reported symptoms, Nagoya City conducted a questionnaire-based survey. Participants were 71,177 female residents of Nagoya City born between April 2, 1994 and April 1, 2001...
February 23, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29458181/hospitalization-burden-associated-with-malignant-neoplasia-and-in-situ-carcinoma-in-vulva-and-vagina-during-a-5-year-period-2009-2013-in-spain-an-epidemiological-study
#15
Noelia López, Ángel Gil-de-Miguel, Raquel Pascual-García, Jose Manuel Ramón Y Cajal, Ruth Gil-Prieto
BACKGROUND: Vulvar and vaginal cancers are considered rare cancers in women. Human Papillomavirus is responsible for 30%-76% of them. The aim of this study was to describe the burden of hospital admissions by malignant neoplasia (MN) and in situ carcinoma (ISC) of vulva and vagina from 2009 to 2013, in Spain METHODS: This observational, descriptive study used discharge information obtained from the national surveillance system for hospital data, Conjunto Mínimo Básico de Datos, CMBD, provided by the Ministry of Health...
February 16, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29355777/redetection-of-human-papillomavirus-type-16-infections-of-the-cervix-in-mid-adult-life
#16
Aaron Ermel, Marcia L Shew, Teresa M Imburgia, Matt Brown, Brahim Qadadri, Yan Tong, Darron R Brown
PURPOSE: To assess whether HPV 16 originally detected in adolescent women can be redetected in adulthood. METHODS: A convenience sample of 27 adult women with known HPV 16 detection during adolescence was assessed for HPV 16 redetection. A comparison of the long control region (LCR) DNA sequences was performed on some of the original and redetected HPV 16 isolates. RESULTS: Median age at reenrollment was 27.5 years (interquartile range of 26...
January 31, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29294358/the-cape-town-declaration-on-human-papillomavirus-related-disease
#17
EDITORIAL
Anna-Lise Williamson, Suzanne Garland, Joel Palefsky, Ed Rybicki, Margaret Stanley, Silvia de Sanjosé
No abstract text is available yet for this article.
December 30, 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/29274466/letter-to-the-editor-in-response-to-tanton-c-et-al-human-papillomavirus-hpv-in-young-women-in-britain-population-based-evidence-ofthe-effectiveness-of-the-bivalent-immunisation-programme-and-burden-of-quadrivalent-and-9-valent-vaccine-types-papillomavirus-res
#18
LETTER
https://www.readbyqxmd.com/read/29277575/therapeutic-vaccines-for-high-risk-hpv-associated-diseases
#19
REVIEW
Aleyo Chabeda, Romana J R Yanez, Renate Lamprecht, Ann E Meyers, Edward P Rybicki, Inga I Hitzeroth
Cancer is the second leading cause of death worldwide, and it is estimated that Human papillomavirus (HPV) related cancers account for 5% of all human cancers. Current HPV vaccines are extremely effective at preventing infection and neoplastic disease; however, they are prophylactic and do not clear established infections. Therapeutic vaccines which trigger cell-mediated immune responses for the treatment of established infections and malignancies are therefore required. The E6 and E7 early genes are ideal targets for vaccine therapy due to their role in disruption of the cell cycle and their constitutive expression in premalignant and malignant tissues...
December 19, 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/29269325/efficacy-immunogenicity-and-safety-of-a-9-valent-human-papillomavirus-vaccine-in-latin-american-girls-boys-and-young-women
#20
Ángela María Ruiz-Sternberg, Edson D Moreira, Jaime A Restrepo, Eduardo Lazcano-Ponce, Robinson Cabello, Arnaldo Silva, Rosires Andrade, Francisco Revollo, Santos Uscanga, Alejandro Victoria, Ana María Guevara, Joaquín Luna, Manuel Plata, Claudia Nossa Dominguez, Edison Fedrizzi, Eugenio Suarez, Julio C Reina, Misoo C Ellison, Erin Moeller, Michael Ritter, Christine Shields, Miguel Cashat, Gonzalo Perez, Alain Luxembourg
BACKGROUND: A 9-valent human papillomavirus (HPV6/11/16/18/31/33/45/52/58; 9vHPV) vaccine was developed to expand coverage of the previously developed quadrivalent (HPV6/11/16/18; qHPV) vaccine. METHODS: Efficacy, immunogenicity, and safety outcomes were assessed in Latin American participants enrolled in 2 international studies of the 9vHPV vaccine, including a randomized, double-blinded, controlled with qHPV vaccine, efficacy, immunogenicity, and safety study in young women aged 16-26 years, and an immunogenicity and safety study in girls and boys aged 9-15 years...
December 19, 2017: Papillomavirus Research
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