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Papillomavirus Research

Tuddow Thaiwong, Dodd G Sledge, Annabel G Wise, Katherine Olstad, Roger K Maes, Matti Kiupel
Canine oral papillomavirus (CPV1, also known as COPV), the most common cause of non-neoplastic papillomas, has not been shown to cause squamous cell carcinomas (SCC). Furthermore, malignant transformation of benign papillomas to SCC has only been reported in a single group of dogs with severe combined immunodeficiency infected with CPV2. Here, we report a series of 7 dogs with benign CPV1-associated papillomas with histologic evidence of CPV1 causing malignant transformation to carcinoma in situ and ultimately SCC...
November 9, 2018: Papillomavirus Research
Gabriella Lillsunde Larsson, Malin Kaliff, Bengt Sorbe, Gisela Helenius, Mats G Karlsson
Vulvar carcinoma is the fourth most common gynecological malignancy. Two separate carcinogenic pathways are suggested, where one is associated with the human papillomavirus (HPV) and HPV16 the most common genotype. The aim of this study was to evaluate HPV-markers in a set of primary tumors, metastases and recurrent lesions of vulvar squamous cell carcinomas (VSCC). Ten HPV16-positive VSCC with metastatic regional lymph nodes, distant lymphoid/hematogenous metastases or local recurrent lesions were investigated for HPV genotype, HPV16 variant, HPV16 viral load, HPV16 integration and HPV16 E2BS3 and 4 methylation...
November 2, 2018: Papillomavirus Research
Pamela J Toliman, John M Kaldor, Steven G Badman, Josephine Gabuzzi, Selina Silim, Antonia Kumbia, Benny Kombuk, Zure Kombati, Gloria Munnull, Rebecca Guy, Lisa M Vallely, Angela Kelly-Hanku, Handan Wand, Claire Ryan, Grace Tan, Julia Brotherton, Marion Saville, Glen D L Mola, Suzanne M Garland, Sepehr N Tabrizi, Andrew J Vallely
The performance of different clinical screening algorithms comprising point-of-care HPV-DNA testing using self-collected vaginal ('V') specimens, and visual inspection of the cervix with acetic acid (VIA) was evaluated in Papua New Guinea. Women aged 30-59 years provided V specimens that were tested at point-of-care using the Xpert HPV Test (Cepheid, Sunnyvale, CA). A clinician-collected cervical ('C') specimen was then collected for point-of-care Xpert testing, and liquid-based cytology (LBC). Following this, VIA examination was conducted, blind to HPV test results, and ablative cervical cryotherapy provided if indicated...
November 1, 2018: Papillomavirus Research
Tumelo R Sekee, Felicity J Burt, Dominique Goedhals, Jacqueline Goedhals, Yuri Munsamy, Riaz Y Seedat
BACKGROUND: Most tumours of the head and neck are attributable to smoking and alcohol use, but an increasing proportion of head and neck tumours are caused by human papillomaviruses (HPVs). The aim of this study was to use in house molecular assays to detect and genotype HPV in biopsies from patients with histologically confirmed head and neck squamous cell carcinomas. In addition, the results were compared with p16 immunohistochemistry staining, which has been described as a potential marker for HPV infection...
November 1, 2018: Papillomavirus Research
Carrie R Innes, Peter H Sykes, Dianne Harker, Jonathan A Williman, Rachael A Van der Griend, Martin Whitehead, Merilyn Hibma, Beverley A Lawton, Peter Fitzgerald, Narena M Dudley, Simone Petrich, Jim Faherty, Cecile Bergzoll, Lois Eva, Lynn Sadler, Bryony J Simcock
In 2008, a quadrivalent human papillomavirus (HPV) vaccine (genotypes 6, 11, 16, 18) became available in New Zealand. This study investigated whether the proportion of cervical intraepithelial neoplasia grade 2 (CIN2) lesions associated with HPV genotypes 16 and 18 changed over time in young women recruited to a prospective CIN2 observational management trial (PRINCess) between 2013 and 2016. Partial HPV genotyping (16, 18, or other high risk HPV) was undertaken on n = 392 women under 25 years (mean age 21...
November 1, 2018: Papillomavirus Research
Jinichi Sakamoto, Shoji Kamiura, Kaori Okayama, Mitsuaki Okodo, Takeo Shibata, Yasuhiro Osaka, Satoko Fujita, Emi Takata, Hiroaki Takagi, Masahiro Takakura, Toshiyuki Sasagawa
To elucidate oncogenic human papilloma virus (HPV) types in Japan, HPV genotyping was performed in 1526 cervical intraepithelial neoplasia (CIN) and 371 invasive cervical cancer (ICC) patients with the novel Genosearch-31+5 HPV test. The HPV-positive rates were 89.3% and 90.8% in CIN and ICC. Regarding single-type infections, 13 internationally recognized high-risk (13HR) types excluding HPV 35, and probably HR HPV 53, 67, 69, and 70 were identified in ICC, suggesting that all these types may be oncogenic. HPV16 and 18 were identified in both SCC and adenocarcinoma (ADC)...
October 26, 2018: Papillomavirus Research
Sally Peprah, Jenell S Coleman, Anne F Rositch, Christopher J Vanden Bussche, Richard Moore, Gypsyamber D'Souza
Frequent Pap testing is recommended among women living with HIV (WLWH) due to their elevated risk for cervical cancer. However, there are few recent longitudinal evaluations of utilization and determinants of Pap testing among WLWH. Medical and pathology records of WLWH seen at Johns Hopkins Hospital between 2005 and 2014 were assessed using Prentice, Williams, Peterson models. Of 554 WLWH in care for ≥ 18 months, 79% received Pap testing, however only 11% consistently received Pap testing at the recommended interval...
October 25, 2018: Papillomavirus Research
Katherine E Gallagher, Helen Kelly, Naomi Cocks, Sandra Dixon, Sandra Mounier-Jack, Natasha Howard, Deborah Watson-Jones
BACKGROUND: The World Health Organization (WHO) recommends a 2-dose HPV vaccine schedule for girls aged 9-14 years. As randomised controlled trials assessing the immunogenicity and efficacy of a 1-dose schedule are ongoing, we interviewed immunisation programme managers and advisors in low and middle-income countries (LMIC) about a hypothetical, future reduction in the HPV vaccine schedule. METHODS: We conducted semi-structured interviews with LMIC immunisation programme managers and national immunisation technical advisory group members (key informants; KIs) in 2017, recruited for their knowledge/experience in national HPV vaccine policy and provision...
October 21, 2018: Papillomavirus Research
Mamiko Onuki, Koji Matsumoto, Yuri Tenjimbayashi, Nobutaka Tasaka, Azusa Akiyama, Manabu Sakurai, Takeo Minaguchi, Akinori Oki, Toyomi Satoh, Hiroyuki Yoshikawa
The prognostic impact of human papillomavirus (HPV) type on invasive cervical cancer (ICC) was analyzed for 137 women treated for ICC at a single institution between 1999 and 2007. The study subjects were divided into three groups according to HPV genotype: HPV16-positive (n = 59), HPV18-positive (n = 33), and HPV16/18-negative ICC (non-HPV16/18, n = 45). The median follow-up time was 102.5 months (range, 5-179). The 10-year overall survival (10y-OS) rates in women with FIGO stage I/II disease were similar among HPV genotypes: 94...
October 19, 2018: Papillomavirus Research
David Guenat, Véronique Dalstein, Frédéric Mauny, Maëlle Saunier, Jenny Briolat, Christine Clavel, Didier Riethmuller, Christiane Mougin, Jean-Luc Prétet
High risk HPV infection is the necessary cause for the development of precancerous and cancerous lesions of the cervix. Among HPV, HPV16 represents the most carcinogenic type. Since the determination of HPV16 DNA load could be clinically useful, we assessed quantitative real-time PCR targeting E6HPV16 and albumin genes on two different platforms. Series of SiHa cells diluted in PreservCyt were used to assess repeatability and reproducibility of two in-house real-time PCR techniques run in two different laboratories to determine HPV16 load...
October 18, 2018: Papillomavirus Research
Jessica M Clark, Emma M Holmes, Daniel A O'Connell, Jeffrey Harris, Hadi Seikaly, Vincent L Biron
BACKGROUND: There is a paucity of studies reporting long-term survival outcomes for HPV/p16 positive oropharyngeal squamous cell carcinoma (OPSCC). This study aims to compare long-term outcomes of advanced stage p16 positive and negative OPSCCs, treated by surgical and non-surgical modalities. METHODS: OPSCC patients from 1998 to 2012 were identified through a prospectively collected cancer registry. P16 immunohistochemistry was used as a surrogate marker for HPV-OPSCC...
September 26, 2018: Papillomavirus Research
Rogomenoma Alice Ouedraogo, Théodora Mahoukèdè Zohoncon, Sindimalgdé Patricia Guigma, Ina Marie Angèle Traore, Abdoul Karim Ouattara, Marie Ouedraogo, Florencia Wendkuuni Djigma, Dorcas Obiri-Yeboah, Charlemagne Ouedraogo, Jacques Simpore
OBJECTIVE: This study was conducted to determine the prevalence and distribution of high-risk human papillomavirus (HR-HPV) genotypes among sexually active women in Tenkodogo, Burkina Faso. METHODS: Among 131 sexually active women attending the Tenkodogo Urban Medical Center, endocervical samples were collected prior to screening for precancerous lesions. After viral DNA extraction, fourteen HR-HPV genotypes were characterized by real-time multiplex PCR in these cervical samples...
September 19, 2018: Papillomavirus Research
Michelle S Cespedes, Minhee Kang, Erna Milunka Kojic, Triin Umbleja, Catherine Godfrey, Jennifer Y Webster-Cyriaque, Reena Masih, Cynthia Firnhaber, Beatriz Grinsztejn, Alfred Saah, Susan Cu-Uvin, Judith A Aberg
OBJECTIVES: People living with HIV have increased Human Papillomavirus (HPV) related lesions and malignancies. We describe HPV DNA recovered from the cervix and anal canal, explore the effect of vaccination on HPV detection, and examine the durability of vaccine titers in women living with HIV-1 who were vaccinated with the quadrivalent HPV vaccine. METHODS: AIDS Clinical Trials Group A5240 was a prospective study of the quadrivalent HPV (qHPV) vaccine in 315 HIV-1 infected women in three CD4 strata (A: >350, B; 201-350, C: ≤200 cells/mm3 )...
August 16, 2018: Papillomavirus Research
Bigyan Mainali, Matthew B Schabath, Staci L Sudenga, Cynthia Ye, Howard W Wiener, Luisa L Villa, Anna R Giuliano, Sadeep Shrestha
OBJECTIVES: While most human papillomavirus (HPV) infection clears on its own, persistent HPV infection can cause genital warts and anal, penile and oropharyngeal cancers in men. We conducted genetic analysis in a sub-cohort of the HPV infection in men (HIM) study to test the hypothesis that differences in host genes influence HPV persistence in men. METHODS: Baseline and longitudinal genital HPV status at the genitals was measured every 6-months using the Linear Array assay amplified HPV L1 gene fragment using the PGMY09/11 L1 consensus primer system...
August 6, 2018: Papillomavirus Research
Z K Tuong, K Noske, P Kuo, A A Bashaw, S M Teoh, I H Frazer
Currently available vaccines prevent HPV infection and development of HPV-associated malignancies, but do not cure existing HPV infections and dysplastic lesions. Persistence of infection(s) in immunocompetent patients may reflect induction of local immunosuppressive mechanisms by HPV, providing a target for therapeutic intervention. We have proposed that a mouse, expressing HPV16 E7 oncoprotein under a Keratin 14 promoter (K14E7 mice), and which develops epithelial hyperplasia, may assist with understanding local immune suppression mechanisms that support persistence of HPV oncogene-induced epithelial hyperplasia...
June 2018: Papillomavirus Research
Rachel L Winer, Tarik Gheit, Stephen Cherne, John Lin, Joshua E Stern, Mario Poljak, Qinghua Feng, Massimo Tommasino
Cutaneous human papillomaviruses (HPVs) have not been evaluated in fingernails from healthy individuals. To determine prevalence and correlates of β-HPVs in fingernails from healthy mid-adult women, we tested archived samples collected from 2011 to 2012 using a multiplex PCR combined with Luminex technology for 46 β-HPV genotypes. One hundred thirteen (61.1%) of 185 fingernail samples were positive for β-HPV, and the median number of types detected in positive samples was 2 (interquartile range: 1-4). The most common genotypes detected were HPV-23 (β-2) (13...
June 2018: Papillomavirus Research
Racheal S Dube Mandishora, Kristina S Gjøtterud, Sonja Lagström, Babill Stray-Pedersen, Kerina Duri, Nyasha Chin'ombe, Mari Nygård, Irene Kraus Christiansen, Ole Herman Ambur, Mike Z Chirenje, Trine B Rounge
Human papillomaviruses (HPVs) co-evolve slowly with the human host and each HPV genotype displays epithelial tropisms. We assessed the evolution of intra HPV genotype variants within samples, and their association to anogenital site, cervical cytology and HIV status. Variability in the L1 gene of 35 HPV genotypes was characterized phylogenetically using maximum likelihood, and portrayed by phenotype. Up to a thousand unique variants were identified within individual samples. In-depth analyses of the most prevalent genotypes, HPV16, HPV18 and HPV52, revealed that the high diversity was dominated by a few abundant variants...
June 2018: Papillomavirus Research
Ditte Møller Ejegod, Helle Pedersen, Garazi Peña Alzua, Camilla Pedersen, Jesper Bonde
As a new initiative, HPV self-sampling to non-attenders using the dry Evalyn self-sampling brush is offered in the Capital Region of Denmark. The use of a dry brush is largely uncharted territory in terms of analytical stability. In this study we aim to provide evidence on the analytical quality of dry HPV self-sampling brushes as a function of time and temperature. We assessed the analytical stability of dry stored Evalyn brushes at three different temperatures, (4 °C, room temperature, 30 °C) and five different storage time points; T = 0 (baseline), 2, 4, 8, 16, and 32 weeks prior to HPV analysis using the BD Onclarity HPV assay...
June 2018: Papillomavirus Research
Azucena Bardají, Carolina Mindu, Orvalho J Augusto, Aina Casellas, Olga Cambaco, Egas Simbine, Graça Matsinhe, Eusébio Macete, Clara Menéndez, Esperança Sevene, Khátia Munguambe
Sub-Saharan Africa concentrates the largest burden of cervical cancer worldwide. The introduction of the HPV vaccination in this region is urgent and strategic to meet global health targets. This was a cross-sectional study conducted in Mozambique prior to the first round of the HPV vaccine demonstration programme. It targeted girls aged 10-19 years old identified from schools and households. Face-to-face structured interviews were conducted. A total of 1147 adolescents were enrolled in three selected districts of the country...
June 2018: Papillomavirus Research
Amal ElAmrani, Tarik Gheit, Mustapha Benhessou, Sandrine McKay-Chopin, Mohammed Attaleb, Souha Sahraoui, Mohammed El Mzibri, Marilys Corbex, Massimo Tommasino, Meriem Khyatti
BACKGROUND: Due to recent technical improvements and some encouraging new results, there has been a resurgence of interest in the possibility that a substantial proportion of breast cancers (BCs) may be caused by viral infections, including Human papillomavirus (HPV). The aim of this study was to determine the prevalence of mucosal and cutaneous HPV in tumours from Moroccan BC patients. MATERIALS AND METHODS: Frozen tumours from 76 BC cases and 12 controls were evaluated for the presence of 62 HPV-types using highly sensitive assays that combine multiplex polymerase chain reaction and bead-based Luminex technology...
June 2018: Papillomavirus Research
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