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Papillomavirus Research

Clare Tanton, David Mesher, Simon Beddows, Kate Soldan, Soazig Clifton, Kavita Panwar, Nigel Field, Catherine H Mercer, Anne M Johnson, Pam Sonnenberg
BACKGROUND: In 2008, the UK introduced an HPV immunisation programme in girls. Population-based prevalence estimates of bivalent (HPV-16/18), quadrivalent (HPV-6/11/16/18) and 9-valent (HPV-6/11/16/18/31/33/45/52/58) vaccine types, and comparison over time, are needed to monitor impact, evaluate effectiveness and guide decision-making on vaccination strategies. METHODS: The third National Survey of Sexual Attitudes and Lifestyles (Natsal-3) in 2010-12, tested urine for HPV from 2569 sexually-experienced women aged 16-44...
June 2017: Papillomavirus Research
Staci L Sudenga, B Nelson Torres, Matthys H Botha, Michele Zeier, Martha E Abrahamsen, Richard H Glashoff, Susan Engelbrecht, Maarten F Schim Van der Loeff, Louvina E Van der Laan, Siegfried Kipping, Douglas Taylor, Anna R Giuliano
BACKGROUND: HPV antibodies are a marker of past exposure to the virus. Our objective was to assess HPV serostatus pre- and post-vaccination among HIV-negative women. METHODS: Women aged 16-24 years old were randomized in a placebo controlled trial utilizing the 4-valent HPV (4vHPV) vaccine (NCT01489527, Participants (n=389) received the 4vHPV vaccine or placebo following a three dose schedule. Sera were collected at Day 1 and Month 7 for assessment of HPV 6, 11, 16, and 18 neutralizing antibody levels using a multiplex competitive Luminex immunoassay (Merck) based on detecting the L1 capsid antigen for each HPV type...
June 2017: Papillomavirus Research
Richard A Hickman, Azore-Dee Bradshaw, Nicholas Cassai, Antonio Galvao Neto, David Zhou, Tinghao Fu, Peng Lee, Zhiheng Pei, Rosemary Wieczorek
Carcinosarcoma of the anus is rare and has yet to be reportedly associated with the keratinocyte-specific Human Papilloma Virus (HPV). We describe a case of anal carcinosarcoma with HPV infection in both the epithelial and mesenchymal components of the tumor by immunohistochemistry, chromogenic in-situ hybridization (CISH) and further supported by electron microscopy (EM). Microscopic examination of the tumor showed nests of poorly-differentiated invasive squamous cell carcinoma with basaloid features intermixed with a hypercellular, atypical spindle cell proliferation...
December 2016: Papillomavirus Research
Daniel C Beachler, Tim Waterboer, Christine M Pierce Campbell, Donna J Ingles, Krystle A Lang Kuhs, Alan G Nyitray, Allan Hildesheim, Michael Pawlita, Aimée R Kreimer, Anna R Giuliano
Antibodies against the Human papillomavirus 16 (HPV16) E6 oncoprotein appear years prior to clinical diagnosis of anal and oropharyngeal cancer, but whether they develop around the time of HPV infection is unclear. Serum samples from 173 cancer-free men from the Human Papillomavirus Infection in Men (HIM) Study were tested for HPV antibodies and DNA. HPV16 E6 seropositivity was low among men with oral HPV16-infection (1/28; 3.6%, 95%CI=0.0%-18.4%), anal HPV16-infection (1/61; 1.6%, 95%CI=0.0%-8.8%), and 24-month persistent genital HPV16-infection (1/84; 1...
December 2016: Papillomavirus Research
Deanna Kepka, Michael G Spigarelli, Echo L Warner, Yukiko Yoneoka, Nancy McConnell, Alfred Balch
BACKGROUND: Human papillomavirus (HPV) vaccine 3-dose completion rates among adolescent females in the US are low. Missed opportunities impede HPV vaccination coverage. METHODS: A population-based secondary data analysis of de-identified vaccination and demographic data from the Utah Statewide Immunization Information System (USIIS) was conducted. Records were included from 25,866 females ages 11-26 years at any time during 2008-2012 who received at least one of the following adolescent vaccinations documented in the USIIS: Tdap (Tetanus, Diphtheria, Pertussis), meningococcal, and/or influenza...
December 2016: Papillomavirus Research
Monica L Kasting, Shannon Wilson, Brian E Dixon, Stephen M Downs, Amit Kulkarni, Gregory D Zimet
BACKGROUND: Provider recommendation is a significant predictor of HPV vaccine uptake. Prior research suggests that concerns regarding risk compensation could cause some providers to hesitate recommending the HPV vaccine. METHODS: During 15-30 minute semi-structured interviews in early 2015, 22 U.S. pediatric providers were asked about their beliefs regarding sexual risk compensation and cervical cancer screening following HPV vaccination. Providers were asked if these beliefs result in reservations recommending the vaccine...
December 2016: Papillomavirus Research
Andrew W Woodham, Lisa Yan, Joseph G Skeate, Daniel van der Veen, Heike H Brand, Michael K Wong, Diane M Da Silva, W Martin Kast
Human papillomavirus type 16 (HPV16) infections are intra-epithelial, and thus, HPV16 is known to interact with Langerhans cells (LCs), the resident epithelial antigen-presenting cells (APCs). The current paradigm for APC-mediated induction of T cell anergy is through delivery of T cell receptor signals via peptides on MHC molecules (signal 1), but without costimulation (signal 2). We previously demonstrated that LCs exposed to HPV16 in vitro present HPV antigens to T cells without costimulation, but it remained uncertain if such T cells would remain ignorant, become anergic, or in the case of CD4+ T cells, differentiate into Tregs...
December 2016: Papillomavirus Research
Erika L Fuchs, Mahbubur Rahman, Abbey B Berenson
PURPOSE: This study examines within-family differences in the uptake of the HPV vaccine and HPV-related beliefs by children's sex. METHODS: From a 2011-2013 survey of mothers of children aged 9-17 years in Texas, mothers with both male and female children (n=350) were selected. RESULTS: Mothers were more likely to report having initiated and completed HPV vaccination for their daughters than sons. Mothers did not express differences by children's sex in HPV-related beliefs...
December 2016: Papillomavirus Research
Daniel C Beachler, Felisa A Gonzales, Sarah C Kobrin, Aimée R Kreimer
BACKGROUND: Since 2006, routine HPV vaccination has been recommended for females aged 11-12 in the US. However not much is known about the extent of and factors associated with HPV vaccination after the ages of 11-12. METHODS: Provider-verified data on 8,710 females aged 13-17 were analyzed from the 2013 NIS-Teen survey. 2013 data was utilized since it was the first year one can fully evaluate the age at vaccination through age 17 for females who could receive the HPV vaccine at age 11...
December 1, 2016: Papillomavirus Research
Guodong Liu, Lan Kong, Ping Du
BACKGROUND: Although HPV vaccination has been recommended for use in girls and young women since 2007, HPV vaccine uptake is low in the US. METHODS: We conducted a retrospective cohort study using the 2008-2011 MarketScan data to examine HPV vaccine completion and dose adherence among commercially insured females aged 9-26 years. We performed multivariable logistic regression models to examine factors related to HPV vaccine completion and HPV vaccine dose adherence...
December 2016: Papillomavirus Research
Donna J Ingles, Hui-Yi Lin, William J Fulp, Staci L Sudenga, Beibei Lu, Matthew B Schabath, Mary R Papenfuss, Martha E Abrahamsen, Jorge Salmeron, Luisa L Villa, Eduardo Lazcano Ponce, Anna R Giuliano
OBJECTIVES: Genital HPV infection in men causes benign and cancerous lesions, the incidence of which differs by age. The goal of this work was to comprehensively evaluate incidence and clearance of individual HPV genotypes among men by age group. METHODS: HIV-negative men ages 18-70 with no history of anogenital cancer were recruited for the HPV Infection in Men (HIM) Study. Participants completed clinical exams and questionnaires every six months for up to ~4 years...
December 2015: Papillomavirus Research
Patricia M Day, Cynthia D Thompson, Yuk Ying Pang, Douglas R Lowy, John T Schiller
We report that during assembly of HPV16 pseudovirus (PsV) the minor capsid protein, L2, interacts with the host nucleolar protein nucleophosmin (NPM1/B23). Exogenously-expressed L2 colocalized with NPM1, a complex containing both proteins could be immunoprecipitated, and L2 could redirect to the nucleus NPM1 that was pharmacologically or genetically restricted to the cytoplasm. Coexpression of the major capsid protein, L1, prevented both the colocalization and the biochemical association, and L1 pentamers could displace L2 from L2/NPM1 complexes attached to a nuclear matrix...
December 2015: Papillomavirus Research
Sung Hee Lee, Chang-Ryul Lee, Nicole Kristina Rigas, Reuben H Kim, Mo K Kang, No-Hee Park, Ki-Hyuk Shin
High-risk human papillomaviruses (e.g., HPV16, HPV18) are closely associated with the development of head and neck cancers including oral/oropharyngeal squamous cell carcinoma (OSCC). We previously demonstrated immortalization of normal human oral keratinocytes by introducing high-risk HPV whole genome, suggesting that HPV infection plays an important role in the early stage of oral carcinogenesis. Although HPV infection may occur in different stages of cancer development, roles of HPV in exacerbating malignant phenotypes in already-transformed cells in the context of cancer stemness are not clearly defined...
December 1, 2015: Papillomavirus Research
Anna R Giuliano, Raphael Viscidi, B Nelson Torres, Donna J Ingles, Staci L Sudenga, Luisa L Villa, Maria Luiza Baggio, Martha Abrahamsen, Manuel Quiterio, Jorge Salmeron, Eduardo Lazcano-Ponce
BACKGROUND: Protection from naturally acquired human papillomavirus (HPV) antibodies may influence HPV infection across the lifespan. This study describes seroconversion rates following genital, anal, and oral HPV 6/11/16/18 infections in men and examines differences by HPV type and anatomic site. METHODS: Men with HPV 6/11/16/18 infections who were seronegative for those genotypes at the time of DNA detection were selected from the HPV Infection in Men (HIM) Study...
December 1, 2015: Papillomavirus Research
Diane M Da Silva, Andrew W Woodham, Laurie K Rijkee, Joseph G Skeate, Julia R Taylor, Maaike E Koopman, Heike E Brand, Michael K Wong, Greg M McKee, Andres M Salazar, W Martin Kast
Human papillomaviruses (HPV) establish persistent infections because of evolved immune evasion mechanisms, particularly HPV-mediated suppression of the immune functions of Langerhans cells (LC), the antigen presenting cells of the epithelium. Polyinosinic-polycytidilic acid (Poly-I:C) is broadly immunostimulatory with the ability to enhance APC expression of costimulatory molecules and inflammatory cytokines resulting in T cell activation. Here we investigated the activation of primary human LC derived from peripheral blood monocytes after exposure to HPV16 virus like particles followed by treatment with stabilized Poly-I:C compounds (s-Poly-I:C), and their subsequent induction of HPV16-specific T cells...
December 1, 2015: Papillomavirus Research
Michael Cullen, Joseph F Boland, Mark Schiffman, Xijun Zhang, Nicolas Wentzensen, Qi Yang, Zigui Chen, Kai Yu, Jason Mitchell, David Roberson, Sara Bass, Laurie Burdette, Moara Machado, Sarangan Ravichandran, Brian Luke, Mitchell J Machiela, Mark Andersen, Matt Osentoski, Michael Laptewicz, Sholom Wacholder, Ashlie Feldman, Tina Raine-Bennett, Thomas Lorey, Philip E Castle, Meredith Yeager, Robert D Burk, Lisa Mirabello
For unknown reasons, there is huge variability in risk conferred by different HPV types and, remarkably, strong differences even between closely related variant lineages within each type. HPV16 is a uniquely powerful carcinogenic type, causing approximately half of cervical cancer and most other HPV-related cancers. To permit the large-scale study of HPV genome variability and precancer/cancer, starting with HPV16 and cervical cancer, we developed a high-throughput next-generation sequencing (NGS) whole-genome method...
December 1, 2015: Papillomavirus Research
Naomi Jay, J Michael Berry, Christine Miaskowski, Misha Cohen, Elizabeth Holly, Teresa M Darragh, Joel M Palefsky
No abstract text is available yet for this article.
December 2015: Papillomavirus Research
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