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Papillomavirus Research

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https://www.readbyqxmd.com/read/28720465/effect-of-age-difference-between-heterosexual-partners-on-risk-of-cervical-cancer-and-human-papillomavirus-infection
#1
Iacopo Baussano, Mireia Diaz, Stephen Tully, Nubia Muñoz, Silvia de Sanjosé, F Xavier Bosch, Silvia Franceschi
BACKGROUND: Age difference (Adiff) within a heterosexual couple may influence a woman's risk of being HPV-positive and developing cervical cancer (CC). METHODS: We assessed the relationship between Adiff within the first and current sexual partnership and risk of CC and HPV infection in 1495 cases and 1358 control women from 6 countries included in IARC's multicentric case-control study (median age: 48 years). RESULTS: Large Adiff within the first partnerships was associated with increased CC risk (OR≥3 vs...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720464/prospects-for-the-new-hpv-prevention-and-control-board
#2
EDITORIAL
Margaret Stanley, Mario Poljak
No abstract text is available yet for this article.
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720463/incidence-rates-of-guillain-barr%C3%A3-gbs-chronic-fatigue-systemic-exertion-intolerance-disease-cfs-seid-and-postural-orthostatic-tachycardia-syndrome-pots-prior-to-introduction-of-human-papilloma-virus-hpv-vaccination-among-adolescent-girls-in-finland-2002-2012
#3
J Skufca, J Ollgren, E Ruokokoski, O Lyytikäinen, H Nohynek
BACKGROUND: In Finland a vaccination programme against human papillomavirus (HPV) was introduced in November 2013 for girls aged 11-12 years with a catchup for girls 13-15 years. Allegations that HPV vaccine is causing Guillain Barré syndrome (GBS) and non-specific diagnostic entities, such as chronic fatigue syndrome/systemic exertion intolerance disease (CFS/SEID) and postural orthostatic tachycardia syndrome (POTS), continue to surface. We examined population register-based incidence rates of CFS/SEID, GBS and POTS to provide baseline data for future HPV vaccine safety evaluations...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720462/a-novel-trivalent-hpv-16-18-58-vaccine-with-anti-hpv-16-and-18-neutralizing-antibody-responses-comparable-to-those-induced-by-the-gardasil-quadrivalent-vaccine-in-rhesus-macaque-model
#4
Fei Yin, Yajun Wang, Na Chen, Dunquan Jiang, Yefeng Qiu, Yan Wang, Mei Yan, Jianping Chen, Haijiang Zhang, Yongjiang Liu
Persistent infection with human papillomavirus (HPV) is a key factor in the development of precancerous lesions and invasive cervical cancer. Prophylactic vaccines to immunize against HPV are an effective approach to reducing HPV related disease burden. In this study, we investigated the immunogenicity and dosage effect of a trivalent HPV 16/18/58 vaccine (3vHPV) produced in Escherichia coli (E.coli), with Gardasil quadrivalent vaccine (4vHPV, Merck & Co.) as a positive control. Sera collected from rhesus macaques vaccinated with three dosage formulations of 3vHPV (termed low-, mid-, and high-dosage formulations, respectively), and the 4vHPV vaccine were analyzed by both Pseudovirus-Based Neutralization Assay (PBNA) and Enzyme-Linked Immunosorbent Assay (ELISA)...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720461/vaccine-preventable-anal-human-papillomavirus-in-australian-gay-and-bisexual-men
#5
I Mary Poynten, Sepehr N Tabrizi, Fengyi Jin, David J Templeton, Dorothy A Machalek, Alyssa Cornall, Samuel Phillips, Christopher K Fairley, Suzanne M Garland, Carmella Law, Andrew Carr, Richard J Hillman, Andrew E Grulich
OBJECTIVE: HPV causes ~90% of anal cancer and HPV16 is the type most commonly associated with anal cancer. Gay and bisexual men (GBM) are at greatly increased risk. We investigated patterns of vaccine-preventable anal HPV in older GBM. METHODS: The Study of the Prevention of Anal Cancer (SPANC) is an ongoing, prospective cohort study of HIV-positive and HIV-negative Australian GBM. Participants completed questionnaires and underwent an anal swab for HPV genotyping using Roche Linear Array...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720460/loss-of-chance-associated-with-sub-optimal-hpv-vaccination-coverage-rate-in-france
#6
Mathieu Uhart, Marjorie Adam, André Dahlab, Xavier Bresse
INTRODUCTION: Since 2007, HPV vaccination programs have been implemented in Europe. Significant real-life impact has already been reported in countries where the programs have been successfully implemented. In France, HPV vaccination coverage rate (VCR) is currently one of the lowest in Europe. This represents a missed opportunity for individuals who will not be protected. The study aimed to estimate the consequences of the sub-optimal VCR. METHODS: A dynamic transmission model was calibrated to the French setting...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720459/investigating-the-role-of-human-papillomavirus-in-lung-cancer
#7
E Argyri, E Tsimplaki, C Marketos, G Politis, E Panotopoulou
Lung cancer is the leading cancer worldwide among men and women with morbidity reaching 1.6 million. Human Papillomavirus is the causal factor of cervical cancer while its association with others is still under investigation. The purpose of our study is to examine the presence of HPV DNA as well as high-risk E6/E7 mRNA in patients with lung cancer. Lung tissues were collected during bronchoscopy and tested for HPV DNA and E6/E7 mRNA. 67 lung tissue samples were analysed. The age range was 49-85 years old (y...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720458/prevalence-of-cutaneous-beta-and-gamma-human-papillomaviruses-in-the-anal-canal-of-men-who-have-sex-with-women
#8
Vitaly Smelov, Rachel Hanisch, Sandrine McKay-Chopin, Olga Sokolova, Carina Eklund, Boris Komyakov, Tarik Gheit, Massimo Tommasino
BACKGROUND: Data regarding anal cutaneous HPV detection among HIV-positive and HIV-negative persons largely relies on studies among men who have sex with men in limited geographical settings. Understanding the distribution, determinants, and potential human health effects of anal cutaneous HPV types among men who have sex with women (MSW) is important. METHODS: Anal canal swab samples from 415 Russian MSW (384 HIV-negative and 31 HIV-positive) were tested for 43 β-HPVs and 29 γ-HPVs, using a multiplex PCR combined with Luminex technology...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720457/high-risk-human-papillomavirus-seroprevalence-in-men-and-women-of-six-different-ethnicities-in-amsterdam-the-netherlands-the-helius-study
#9
C J Alberts, A Michel, S Bruisten, M B Snijder, M Prins, T Waterboer, M F Schim van der Loeff
BACKGROUND: Ethnic variations in the (sero)prevalence of Human Papillomavirus (HPV) and HPV related diseases have been observed previously. We explored if high-risk HPV (hrHPV) seropositivity indeed differs among 6 ethnic groups in Amsterdam the Netherlands and assessed if hrHPV seroprevalence is higher among women than men within each ethnic group, both after adjustment for confounders. METHODS: From the multi-ethnic HEalthy Life In an Urban Setting (HELIUS) study in Amsterdam (the Netherlands) we randomly selected 4637 men and women aged 18-44 years with a Dutch, South-Asian Surinamese, African Surinamese, Ghanaian, Moroccan, or Turkish ethnicity...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720456/mechanistic-mathematical-models-an-underused-platform-for-hpv-research
#10
REVIEW
Marc D Ryser, Patti E Gravitt, Evan R Myers
Health economic modeling has become an invaluable methodology for the design and evaluation of clinical and public health interventions against the human papillomavirus (HPV) and associated diseases. At the same time, relatively little attention has been paid to a different yet complementary class of models, namely that of mechanistic mathematical models. The primary focus of mechanistic mathematical models is to better understand the intricate biologic mechanisms and dynamics of disease. Inspired by a long and successful history of mechanistic modeling in other biomedical fields, we highlight several areas of HPV research where mechanistic models have the potential to advance the field...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720455/reasons-for-acceptance-or-refusal-of-human-papillomavirus-vaccine-in-a-california-pediatric-practice
#11
Brandon Brown, Magi Ishak Gabra, Harry Pellman
Despite the effectiveness and availability of the Human Papillomavirus (HPV) vaccine, HPV remains the most common sexually transmitted infection in the United States and has the lowest initiation rate of any routinely recommended teen vaccine. In January 2015, we surveyed parents at a Southern California pediatric private practice about reasons they accept or refuse HPV vaccine for their children. Of the 200 consecutive parents that had HPV vaccine initiation recommended for their child, 123 (61.5%) children were male and 38...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720454/comparative-accuracy-of-pap-smear-and-hpv-screening-in-ubon-ratchathani-in-thailand
#12
Suleeporn Sangrajrang, Piyawat Laowahutanont, Metee Wongsena, Richard Muwonge, Anant Karalak, Weerawut Imsamran, Virginia Senkomago, Rengaswamy Sankaranarayanan
We evaluate the potential for using high-risk human papillomavirus (hr-HPV) testing-based screening for cervical intraepithelial neoplasia (CIN) in routine health services in Thailand; its accuracy in comparison to that of conventional cytology (CC); and the utility of HPV16/18 positive results and liquid-based cytology (LBC) triage for HPV-positive women in the detection of high-grade CIN. Women aged 30-60 years in Ubon Ratchathani province, Thailand were screened with CC and hr-HPV testing and those abnormal on either tests were referred for colposcopy and/or directed biopsies...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720453/parental-acceptance-of-human-papillomavirus-vaccinations-and-community-pharmacies-as-vaccination-settings-a-qualitative-study-in-alabama
#13
Salisa C Westrick, Lindsey A Hohmann, Stuart J McFarland, Benjamin S Teeter, Kara K White, Tessa J Hastings
PURPOSE: To determine parents' knowledge and attitudes regarding human papillomavirus (HPV) vaccinations in their adolescent children and to describe parents' perceptions of adolescent vaccinations in community pharmacies. METHODS: In-depth interviews were completed with parents or guardians of children ages 11-17 years from Alabama's Lee and Macon counties. One-hour long, open-ended telephonic or in-person interviews were conducted until the saturation point was reached...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720452/socioeconomic-predictors-of-human-papillomavirus-vaccination-in-danish-men-a-nationwide-study
#14
Signe Bollerup, Birgitte Baldur-Felskov, Christian Dehlendorff, Susanne K Kjaer
BACKGROUND: The quadrivalent human papillomavirus vaccine was licensed in Denmark in 2006. Unlike women, men are not offered human papillomavirus vaccination free of charge but can have it at their own expense. We investigated human papillomavirus vaccine uptake by men in Denmark and the socioeconomic factors that may predict human papillomavirus vaccination. METHODS: Using the Civil Registration System, we identified all boys and men aged 9-26 years in 2006-2013 and their mothers...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720451/high-diversity-of-alpha-beta-and-gamma-human-papillomaviruses-in-genital-samples-from-hiv-negative-and-hiv-positive-heterosexual-south-african-men
#15
Tracy L Meiring, Zizipho Z A Mbulawa, Maia Lesosky, David Coetzee, Anna-Lise Williamson
BACKGROUND: This study investigated the prevalence of HPVs in heterosexual South African men and the impact of HIV co-infection. METHODS: HPV was detected in penile swabs from 195 HIV-infected and 140 HIV-uninfected men using PCR with FAP59/64 primers and Roche Linear Array HPV genotyping (LA). Genotyping of FAP positive specimens was achieved by high-throughput sequencing of amplicons. RESULTS: HPV was detected by FAP PCR and LA in 79% (266/335) of the men...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720450/detection-of-cervical-precancerous-lesions-with-aptima-hpv-assays-using-surepath-preservative-fluid-specimens
#16
Max Chernesky, Dan Jang, Nick Escott, Jodi Gilchrist, Jenny Li, Laurie Elit, Alice Lytwyn, Marek Smieja, Sam Ratnam, Manuel Arias, Damon Getman, Barbara Weinbaum, Brett Kirkconnell, Janel Dockter
SurePath specimens from women referred to colposcopy were treated with Aptima Transfer Solution (ATS) before testing in Aptima HPV (AHPV) and Aptima HPV 16, 18/45 (AHPV-GT) assays. Untreated SurePath specimens were tested with the cobas HPV test. PreservCyt specimens were assessed for cytology and tested with AHPV. High-grade cervical intraepithelial neoplasia lesions served as the reference standard. Excellent agreement (95.5%; k=0.91) was observed for ATS-treated SurePath specimens between Tigris and Panther systems and between the PreservCyt and ATS-treated SurePath specimens (91...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720449/human-papillomavirus-in-anal-biopsy-tissues-and-liquid-based-cytology-samples-of-hiv-positive-and-hiv-negative-thai-men-who-have-sex-with-men
#17
Tippawan Pankam, Stephen J Kerr, Nipat Teeratakulpisan, Piyanee Rodbamrung, Rapeeporn Wongkanya, Somboon Keelawat, Komkrit Ruangritchankul, Piranun Hongchookiat, Ramida Watanapokasin, Nittaya Phanuphak
BACKGROUND: Men who have sex with men (MSM) are at high risk of developing human papillomavirus (HPV)-related anal cancer. We compared HPV genotypes in anal tissues (Bx) and anal liquid-based cytology fluid (LBC) from HIV-positive and HIV-negative MSM. METHODS: Bx (32 normal, 41 low-grade squamous intraepithelial lesions (LSIL) and 22 high-grade squamous intraepithelial lesions (HSIL)), along with LBC from the same visit, were selected from 61 HIV-positive and 34 HIV-negative MSM who enrolled into a prospective cohort in Bangkok, Thailand...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720448/the-feminization-of-hpv-how-science-politics-economics-and-gender-norms-shaped-u-s-hpv-vaccine-implementation
#18
Ellen M Daley, Cheryl A Vamos, Erika L Thompson, Gregory D Zimet, Zeev Rosberger, Laura Merrell, Nolan S Kline
Human papillomavirus (HPV) can cause a number of anogenital cancers (i.e., cervical, penile, anal, vaginal, vulvar) and genital warts. A decade ago, the HPV vaccine was approved, and has been shown to be a public health achievement that can reduce the morbidity and mortality for HPV-associated diseases. Yet, the mistaken over-identification of HPV as a female-specific disease has resulted in the feminization of HPV and HPV vaccines. In this critical review, we trace the evolution of the intersection of science, politics, economics and gender norms during the original HPV vaccine approval, marketing era, and implementation...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720447/projected-impact-of-hpv-vaccination-and-primary-hpv-screening-on-cervical-adenocarcinoma-example-from-australia
#19
Megan A Smith, Karen Canfell
Cytology-based cervical screening appears to have had a limited effect on the incidence of adenocarcinoma, however HPV vaccination and HPV-based screening will likely play a role in reducing future burden. Using Australia as an example, we estimated the future burden (2015-2040) of adenocarcinoma in the absence of other interventions; and the impact of HPV vaccination (introduced 2007) and HPV-based screening (commencing 2017). Future burden was estimated considering underlying trends in adenocarcinoma, using national data (1982-2010)...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720446/acceptability-of-multipurpose-human-papillomavirus-vaccines-among-providers-and-mothers-of-adolescent-girls-a-mixed-methods-study-in-five-countries
#20
Nadja A Vielot, Shoshana K Goldberg, Gregory Zimet, Sara B Smith, Mary Anne McDonald, Silvina Ramos, Karen Morgan, Chan Joo Kim, Karin L Richter, Merce Peris, Kevin J Whaley, Jennifer S Smith
INTRODUCTION: Multipurpose vaccines (MPVs) could be formulated to prevent multiple sexually transmitted infections simultaneously. Little is known about acceptability of MPVs among vaccine health care providers (HCPs) or mothers of adolescent girls. METHODS: 151 adolescent vaccine providers and 118 mothers of adolescent girls aged 9-14 were recruited from five geographically-diverse countries: Argentina, Malaysia, South Africa, South Korea, and Spain. We assessed providers' preferences for single-purpose human papillomavirus (HPV) vaccine versus MPVs (including HPV+herpes simplex virus (HSV)-2, HPV+HIV, or HPV+HSV-2+HIV) via quantitative surveys...
June 2017: Papillomavirus Research
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