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Papillomavirus Research

M Chernesky, D Jang, J Schweizer, M Arias, L Doerwald-Munoz, M Gupta, B Jackson, S Archibald, J Young, A Lytwyn, M Smieja, A Severini, A Ecobichon-Morris, M Hyrcza
Commercial assays measuring HPV E6 viral oncoproteins, E6/E7 mRNA or DNA were used to test neck lymph node fine needle aspirates (FNA) and oropharyngeal samples (saliva and oral swabs) from 59 Canadian patients with oropharyngeal squamous cell carcinomas (OPSCC). Overall agreements of p16 antigen staining of tumors to FNA tested for OncoE6TM , Aptima HPV E6/E7 mRNA and cobas HPV DNA were 81.4% (k 0.53), 94.9% (k 0.83) and 91.1% (k 0.73) respectively. Using HPV presence in a subset of 25 tumors as the comparator, overall agreement was 64...
May 26, 2018: Papillomavirus Research
G B Ellsworth, S Y Lensing, C B Ogilvie, J Y Lee, S E Goldstone, J M Berry-Lawhorn, N Jay, E A Stier, J S Logan, M H Einstein, A Saah, R T Mitsuyasu, D Aboulafia, J M Palefsky, T J Wilkin
No abstract text is available yet for this article.
May 25, 2018: Papillomavirus Research
Manako Yamaguchi, Masayuki Sekine, Risa Kudo, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Megumi Hara, Sharon J B Hanley, Takayuki Enomoto
Japan has no national vaccine registry and approximately 1700 municipalities manage the immunization records independently. In June 2013, proactive recommendations for the human papillomavirus (HPV) vaccine were suspended after unconfirmed reports of adverse events following immunization in the media, despite no vaccine safety signal having been raised. Furthermore, studies assessing HPV vaccine safety and effectiveness published post suspension are predominantly based on self-reported information. Our aim was to examine the accuracy of self-reported vaccination status compared with official municipal records...
May 25, 2018: Papillomavirus Research
Racheal S Dube Mandishora, Kristina S Gjøtterud, Sonja Lagström, Babill Stray-Pedersen, Kerina Duri, Nyasha Chin'ombe, Mari Nygård, Irene Kraus Christiansen, Ole Herman Ambur, Mike Z Chirenje, Trine B Rounge
Human papillomaviruses (HPVs) co-evolve slowly with the human host and each HPV genotype displays epithelial tropisms. We assessed the evolution of intra HPV genotype variants within samples, and their association to anogenital site, cervical cytology and HIV status. Variability in the L1 gene of 35 HPV genotypes was characterized phylogenetically using maximum likelihood, and portrayed by phenotype. Up to a thousand unique variants were identified within individual samples. In-depth analyses of the most prevalent genotypes, HPV16, HPV18 and HPV52, revealed that the high diversity was dominated by a few abundant variants...
April 30, 2018: Papillomavirus Research
Z K Tuong, K Noske, P Kuo, A A Bashaw, S M Teoh, I H Frazer
Currently available vaccines prevent HPV infection and development of HPV-associated malignancies, but do not cure existing HPV infections and dysplastic lesions. Persistence of infection(s) in immunocompetent patients may reflect induction of local immunosuppressive mechanisms by HPV, providing a target for therapeutic intervention. We have proposed that a mouse, expressing HPV16 E7 oncoprotein under a Keratin 14 promoter (K14E7 mice), and which develops epithelial hyperplasia, may assist with understanding local immune suppression mechanisms that support persistence of HPV oncogene-induced epithelial hyperplasia...
June 2018: Papillomavirus Research
Rachel L Winer, Tarik Gheit, Stephen Cherne, John Lin, Joshua E Stern, Mario Poljak, Qinghua Feng, Massimo Tommasino
Cutaneous human papillomaviruses (HPVs) have not been evaluated in fingernails from healthy individuals. To determine prevalence and correlates of β-HPVs in fingernails from healthy mid-adult women, we tested archived samples collected from 2011 to 2012 using a multiplex PCR combined with Luminex technology for 46 β-HPV genotypes. One hundred thirteen (61.1%) of 185 fingernail samples were positive for β-HPV, and the median number of types detected in positive samples was 2 (interquartile range: 1-4). The most common genotypes detected were HPV-23 (β-2) (13...
June 2018: Papillomavirus Research
Ditte Møller Ejegod, Helle Pedersen, Garazi Peña Alzua, Camilla Pedersen, Jesper Bonde
As a new initiative, HPV self-sampling to non-attenders using the dry Evalyn self-sampling brush is offered in the Capital Region of Denmark. The use of a dry brush is largely uncharted territory in terms of analytical stability. In this study we aim to provide evidence on the analytical quality of dry HPV self-sampling brushes as a function of time and temperature. We assessed the analytical stability of dry stored Evalyn brushes at three different temperatures, (4 °C, room temperature, 30 °C) and five different storage time points; T = 0 (baseline), 2, 4, 8, 16, and 32 weeks prior to HPV analysis using the BD Onclarity HPV assay...
June 2018: Papillomavirus Research
Azucena Bardají, Carolina Mindu, Orvalho J Augusto, Aina Casellas, Olga Cambaco, Egas Simbine, Graça Matsinhe, Eusébio Macete, Clara Menéndez, Esperança Sevene, Khátia Munguambe
Sub-Saharan Africa concentrates the largest burden of cervical cancer worldwide. The introduction of the HPV vaccination in this region is urgent and strategic to meet global health targets. This was a cross-sectional study conducted in Mozambique prior to the first round of the HPV vaccine demonstration programme. It targeted girls aged 10-19 years old identified from schools and households. Face-to-face structured interviews were conducted. A total of 1147 adolescents were enrolled in three selected districts of the country...
June 2018: Papillomavirus Research
Amal ElAmrani, Tarik Gheit, Mustapha Benhessou, Sandrine McKay-Chopin, Mohammed Attaleb, Souha Sahraoui, Mohammed El Mzibri, Marilys Corbex, Massimo Tommasino, Meriem Khyatti
BACKGROUND: Due to recent technical improvements and some encouraging new results, there has been a resurgence of interest in the possibility that a substantial proportion of breast cancers (BCs) may be caused by viral infections, including Human papillomavirus (HPV). The aim of this study was to determine the prevalence of mucosal and cutaneous HPV in tumours from Moroccan BC patients. MATERIALS AND METHODS: Frozen tumours from 76 BC cases and 12 controls were evaluated for the presence of 62 HPV-types using highly sensitive assays that combine multiplex polymerase chain reaction and bead-based Luminex technology...
June 2018: Papillomavirus Research
Sérgio Menezes Amaro-Filho, Cláudia Bessa Pereira Chaves, Shayany Pinto Felix, Diogo Lisbôa Basto, Liz Maria de Almeida, Miguel Angelo Martins Moreira
OBJECTIVES: To compare and describe type-specific characteristics of HPV16, HPV18 and HPV45 in cervical cancer with respect to 3'LCR methylation and disruption of E1/E2. METHODS: The methylation level of 137 cervical cancer samples (70 with HPV16, 37 with HPV18, and 30 with HPV45) of Brazilian patients was analyzed by pyrosequencing. PCR amplifications were performed to characterize E1 and E2 disruption as an episomal surrogate. RESULTS: The 3'LCR of HPV16 showed a higher methylation at all CpG sites (7%, 9%, 11%, 10% and 10%) than homologous HPV18 regions (4%, 5%...
June 2018: Papillomavirus Research
Hilary A Robbins, Dorothy J Wiley, Ken Ho, Michael Plankey, Susheel Reddy, Nancy Joste, Teresa M Darragh, Elizabeth C Breen, Stephen Young, Gypsyamber D'Souza
BACKGROUND: Men who have sex with men (MSM) are at increased risk for anal cancer. In cervical cancer screening, patterns of repeated cytology results are used to identify low- and high-risk women, but little is known about these patterns for anal cytology among MSM. METHODS: We analyzed Multicenter AIDS Cohort Study (MACS) data for MSM who were offered anal cytology testing annually (HIV-positive) or every 2 years (HIV-negative) for 4 years. RESULTS: Following an initial negative (normal) cytology, the frequency of a second negative cytology was lower among HIV-positive MSM with CD4 ≥ 500 (74%) or CD4 < 500 (68%) than HIV-negative MSM (83%) (p < 0...
June 2018: Papillomavirus Research
A Scott LaJoie, Jelani C Kerr, Richard D Clover, Diane M Harper
OBJECTIVE: The purpose of the study was to assess the knowledge, attitudes and beliefs of male and female college students in Kentucky about HPV associated diseases and vaccines, and to determine which parameters predicted self-reported uptake of HPV vaccination. MATERIALS AND METHODS: A self-selected cross-sectional sample of college students completed an evidence-based online survey. RESULTS: Of approximately 1200 potential respondents, 585 completed the survey...
June 2018: Papillomavirus Research
Neerja Bhatla, Bhagwan M Nene, Smita Joshi, Pulikottil O Esmy, Usha Rani Reddy Poli, Geeta Joshi, Yogesh Verma, Eric Zomawia, Sharmila Pimple, Priya R Prabhu, Partha Basu, Richard Muwonge, Sanjay Hingmire, Catherine Sauvaget, Eric Lucas, Michael Pawlita, Tarik Gheit, Kasturi Jayant, Sylla G Malvi, Maqsood Siddiqi, Angelika Michel, Julia Butt, Subha Sankaran, Thiraviam Pillai Rameshwari Ammal Kannan, Rintu Varghese, Uma Divate, Martina Willhauck-Fleckenstein, Tim Waterboer, Martin Müller, Peter Sehr, Alka Kriplani, Gauravi Mishra, Radhika Jadhav, Ranjit Thorat, Massimo Tommasino, M Radhakrishna Pillai, Rengaswamy Sankaranarayanan
Extending two-dose recommendations of HPV vaccine to girls between 15 and 18 years will reduce program cost and improve compliance. Immunogenicity and vaccine targeted HPV infection outcomes were compared between 1795 girls aged 15-18 years receiving two (1-180 days) and 1515 girls of same age receiving three (1-60-180 days) doses. Immunogenicity outcomes in 15-18 year old two-dose recipients were also compared with the 10-14 year old three-dose (N = 2833) and two-dose (N = 3184) recipients. The 15-18 year old two-dose recipients had non-inferior L1-binding antibody titres at seven months against vaccine-targeted HPV types compared to three-dose recipients at 15-18 years and three-dose recipients at 10-14 years of age...
June 2018: Papillomavirus Research
Aaron Ermel, Marcia L Shew, Teresa M Imburgia, Matt Brown, Brahim Qadadri, Yan Tong, Darron R Brown
PURPOSE: To assess whether HPV 16 originally detected in adolescent women can be redetected in adulthood. METHODS: A convenience sample of 27 adult women with known HPV 16 detection during adolescence was assessed for HPV 16 redetection. A comparison of the long control region (LCR) DNA sequences was performed on some of the original and redetected HPV 16 isolates. RESULTS: Median age at reenrollment was 27.5 years (interquartile range of 26...
June 2018: Papillomavirus Research
Anna-Lise Williamson, Suzanne Garland, Joel Palefsky, Ed Rybicki, Margaret Stanley, Silvia de Sanjosé
No abstract text is available yet for this article.
June 2018: Papillomavirus Research
Aleyo Chabeda, Romana J R Yanez, Renate Lamprecht, Ann E Meyers, Edward P Rybicki, Inga I Hitzeroth
Cancer is the second leading cause of death worldwide, and it is estimated that Human papillomavirus (HPV) related cancers account for 5% of all human cancers. Current HPV vaccines are extremely effective at preventing infection and neoplastic disease; however, they are prophylactic and do not clear established infections. Therapeutic vaccines which trigger cell-mediated immune responses for the treatment of established infections and malignancies are therefore required. The E6 and E7 early genes are ideal targets for vaccine therapy due to their role in disruption of the cell cycle and their constitutive expression in premalignant and malignant tissues...
June 2018: Papillomavirus Research
Eli D Ehrenpreis, Dylan G Smith
BACKGROUND: Women with cervical cancer often have anal human papillomavirus (HPV) infection and anal dysplasia. However, effectiveness of anal HPV screening is unknown. METHODS: A dynamic model was constructed using STELLA. Populations are represented as "stocks" that change according to model rates. Initial anal cytology in new cervical cancer patients, dysplasia progression and regression, cost of treating high-grade squamous intraepithelial lesions (HSIL), and lifetime costs for anal cancer care were extrapolated from the literature...
June 2018: Papillomavirus Research
Ángela María Ruiz-Sternberg, Edson D Moreira, Jaime A Restrepo, Eduardo Lazcano-Ponce, Robinson Cabello, Arnaldo Silva, Rosires Andrade, Francisco Revollo, Santos Uscanga, Alejandro Victoria, Ana María Guevara, Joaquín Luna, Manuel Plata, Claudia Nossa Dominguez, Edison Fedrizzi, Eugenio Suarez, Julio C Reina, Misoo C Ellison, Erin Moeller, Michael Ritter, Christine Shields, Miguel Cashat, Gonzalo Perez, Alain Luxembourg
BACKGROUND: A 9-valent human papillomavirus (HPV6/11/16/18/31/33/45/52/58; 9vHPV) vaccine was developed to expand coverage of the previously developed quadrivalent (HPV6/11/16/18; qHPV) vaccine. METHODS: Efficacy, immunogenicity, and safety outcomes were assessed in Latin American participants enrolled in 2 international studies of the 9vHPV vaccine, including a randomized, double-blinded, controlled with qHPV vaccine, efficacy, immunogenicity, and safety study in young women aged 16-26 years, and an immunogenicity and safety study in girls and boys aged 9-15 years...
June 2018: Papillomavirus Research
Philippe Gorphe, Younès Chekkoury Idrissi, Yungan Tao, Antoine Schernberg, Dan Ou, Stéphane Temam, Odile Casiraghi, Pierre Blanchard, Haïtham Mirghani
OBJECTIVES: We investigated the prognostic value of pre-treatment hematological parameters in patients with p16-positive oropharyngeal squamous-cell carcinoma (OPSCC). MATERIAL AND METHODS: Neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio (NLR), and hemoglobin concentration measurement (Hb), were collected on day one of treatment. Endpoints were overall survival (OS) and progression-free survival (PFS). All patients were planned to receive concurrent chemoradiation...
June 2018: Papillomavirus Research
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