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Burns and Trauma

Dmitry Zavlin, Vishwanath Chegireddy, Stefanos Boukovalas, Anna M Nia, Ludwik K Branski, Jeffrey D Friedman, Anthony Echo
Background: Previous reports individually identified different factors that predict death after burns. The authors employed the multi-center American Burn Association's (ABA) National Burn Repository (NBR) to elucidate which parameters have the highest negative impact on burn mortality. Methods: We audited data from the NBR v8.0 for the years 2002-2011 and included 137,061 patients in our study. The cases were stratified into two cohorts based on the primary outcome of death/survival and then evaluated for demographic data, intraoperative details, and their morbidity after admission...
2018: Burns and Trauma
Laura Pompermaier, Moustafa Elmasry, Islam Abdelrahman, Mats Fredrikson, Folke Sjöberg, Ingrid Steinvall
Background: Disparity between medical treatment for men and women has been recorded worldwide. However, it is difficult to find out if the disparities in both the use of resources and outcome depend entirely on sex-related discrimination. Our aim was to investigate if there are differences in burn treatments between the sexes. Methods: All patients admitted with burns to Linköping University Hospital during the 16-year period 2000-2015 were included. Interventions were prospectively recorded using the validated Burn SCoring system (BSC)...
2018: Burns and Trauma
Jong Dae Kim, Suk Joon Oh, Sun Gyu Kim, Song Vogue Ahn, Yu Jin Jang, Ban Seok Yang, Ji Yun Jeong, Kwang Jo Kim
Background: This study aimed to investigate the difference between ultrasonographic findings of normal skin and those of re-epithelialized skin after partial-thickness burns and to evaluate the relationship between these findings and clinical outcomes. Methods: This study retrospectively analysed the ultrasound images of re-epithelialized skin after partial-thickness burns and contralateral normal skin from January 2016 to December 2016. A total of 155 lesions from 148 patients were analysed with ultrasound images, and healing time was documented...
2018: Burns and Trauma
Cheng Hean Lo, Simone H Nothdurft, Hye-Sung Park, Eldho Paul, James Leong
Background: The purpose of this study is to present our experience with the modified pins and rubber band traction system, discuss problems encountered, and make recommendations to optimize outcomes. Methods: Data was collected prospectively from November 2013 to March 2017 at a tertiary referral hospital in Melbourne, Australia. Patients with closed complex proximal interphalangeal joint fracture dislocations that were considered unsuitable for other surgical options were included in the study...
2018: Burns and Trauma
Akhtar Bibi, Sundas Kalim, Muhammad Adnan Khalid
Background: Post-traumatic stress disorder (PTSD) is one of the major psychological disorders developed after burn injuries, though this subject of burn injuries and their destructive chronic psychological impact are not considered as thoughtfully in developing countries like Pakistan. Hence, the current study investigated the relationship between PTSD symptoms and resilience among burn patients in Pakistan, exploring the variance occurrence of the two variables concerning male burn patients and female burn patients...
2018: Burns and Trauma
Steven T Boyce, Andrea L Lalley
Engineering of biologic skin substitutes has progressed over time from individual applications of skin cells, or biopolymer scaffolds, to combinations of cells and scaffolds for treatment, healing, and closure of acute and chronic skin wounds. Skin substitutes may be categorized into three groups: acellular scaffolds, temporary substitutes containing allogeneic skin cells, and permanent substitutes containing autologous skin cells. Combined use of acellular dermal substitutes with permanent skin substitutes containing autologous cells has been shown to provide definitive wound closure in burns involving greater than 90% of the total body surface area...
2018: Burns and Trauma
Pippa Kenworthy, Michael Phillips, Tiffany L Grisbrook, William Gibson, Fiona M Wood, Dale W Edgar
Background: Major burns are life threatening. Fluid resuscitation is required for survival to maintain intravascular volumes and prevent hypovolemic shock. Bioimpedance spectroscopy (BIS) has been recognised as a potential method of monitoring fluid shifts after burn and in other disease states. The aims of this study were to examine the reliability of BIS across different dressing conditions and electrode positions, establish the influence of Acticoat™ on BIS variable measures and determine the validity of whole-body BIS to assess net fluid shift in the presence of moderate to major burns...
2018: Burns and Trauma
Kevin Serror, Marc Chaouat, Golda Romano, Magali Schmidt, Alice Blet, Maurice Mimoun, David Boccara
Background: In well-selected cases, flaps can play a pivotal role in optimizing outcomes in the acute phase of burns. A previous redundant flap could be reused or recycled as a donor site from which a new flap could be raised. Case presentation: We report the case of a patient with full thickness burns on both legs, leading to the exposure of joints of the right ankle and the right foot and left patellar tendon. The right lower extremity was covered with a free musculo-cutaneous latissimus dorsi flap...
2018: Burns and Trauma
Guangping Tai, Michael Tai, Min Zhao
Naturally occurring electric fields are known to be morphogenetic cues and associated with growth and healing throughout mammalian and amphibian animals and the plant kingdom. Electricity in animals was discovered in the eighteenth century. Electric fields activate multiple cellular signaling pathways such as PI3K/PTEN, the membrane channel of KCNJ15/Kir4.2 and intracellular polyamines. These pathways are involved in the sensing of physiological electric fields, directional cell migration (galvanotaxis, also known as electrotaxis), and possibly other cellular responses...
2018: Burns and Trauma
Andrew Gleadall, Dafydd Visscher, Jing Yang, Daniel Thomas, Joel Segal
Material extrusion additive manufacturing has rapidly grown in use for tissue engineering research since its adoption in the year 2000. It has enabled researchers to produce scaffolds with intricate porous geometries that were not feasible with traditional manufacturing processes. Researchers can control the structural geometry through a wide range of customisable printing parameters and design choices including material, print path, temperature, and many other process parameters. Currently, the impact of these choices is not fully understood...
2018: Burns and Trauma
Ting Xie, Junna Ye, Kittipan Rerkasem, Rajgopal Mani
Venous ulcers are a common chronic problem in many countries especially in Northern Europe and USA. The overall prevalence of this condition is 1% rising to 3% in the over 65 years of age. Over the last 25 years, there have been many developments applicable to its diagnosis and treatment. These advances, notwithstanding healing response and recurrence, are variable, and the venous ulcer continues to be a clinical challenge. The pathogenesis of venous ulcers is unrelieved or ambulatory venous hypertension resulting mostly from deep venous thrombosis leading to venous incompetence, lipodermatosclerosis, leucocyte plugging of the capillaries, tissue hypoxia and microvascular dysfunction...
2018: Burns and trauma
Janine M Duke, Sean M Randall, James H Boyd, Mark W Fear, Suzanne Rea, Fiona M Wood
Background: Injury triggers a range of systemic effects including inflammation and immune responses. This study aimed to compare infectious disease admissions after burn and other types of injury using linked hospital admissions data. Methods: A retrospective longitudinal study using linked health data of all patients admitted with burns in Western Australia ( n  = 30,997), 1980-2012, and age and gender frequency matched cohorts of people with non-burn trauma ( n  = 28,647) and no injury admissions ( n  = 123,399)...
2018: Burns and trauma
Dafydd O Visscher, Sjoerd Te Slaa, Mariëlle E Jaspers, Marloes van de Hulsbeek, Jorien Borst, Jan Wolff, Tymour Forouzanfar, Paul P van Zuijlen
No abstract text is available yet for this article.
2018: Burns and Trauma
Zhe Li, Peter Maitz
Cell therapy has emerged as an important component of life-saving procedures in treating burns. Over past decades, advances in stem cells and regenerative medicine have offered exciting opportunities of developing cell-based alternatives and demonstrated the potential and feasibility of various stem cells for burn wound healing. However, there are still scientific and technical issues that should be resolved to facilitate the full potential of the cellular devices. More evidence from large, randomly controlled trials is also needed to understand the clinical impact of cell therapy in burns...
2018: Burns and Trauma
Hao Tian, Liangxi Wang, Weiguo Xie, Chuanan Shen, Guanghua Guo, Jiaqi Liu, Chunmao Han, Licheng Ren, Yi Liang, Yong Tang, Yuan Wang, Meifang Yin, Jiaping Zhang, Yuesheng Huang
Background: Severe burns injury is a serious pathology, leading to teratogenicity and significant mortality, and it also has a long-term social impact. The aim of this article is to describe the hospitalized population with severe burns injuries in eight burn centers in China between 2011 and 2015 and to suggest future preventive strategies. Methods: This 5-year retrospective review included all patients with severe burns in a database at eight institutions. The data collected included gender, age, month distribution, etiology, location, presence of inhalation injury, total burn surface area, depth of the burn, the length of hospitalization, and mortality...
2018: Burns and Trauma
Tengfei Liu, Yuqing Liu, Menglong Liu, Ying Wang, Weifeng He, Gaoqiang Shi, Xiaohong Hu, Rixing Zhan, Gaoxing Luo, Malcolm Xing, Jun Wu
Background: Bacterial infection is one of the most common complications in burn, trauma, and chronic refractory wounds and is an impediment to healing. The frequent occurrence of antimicrobial-resistant bacteria due to irrational application of antibiotics increases treatment cost and mortality. Graphene oxide (GO) has been generally reported to possess high antimicrobial activity against a wide range of bacteria in vitro . In this study, a graphene oxide-quaternary ammonium salt (GO-QAS) nanocomposite was synthesized and thoroughly investigated for synergistic antibacterial activity, underlying antibacterial mechanisms and biocompatibility in vitro and in vivo ...
2018: Burns and Trauma
Ian C C King
Burn injuries in children can result in life-long disfigurement. As medical and surgical techniques of burn management improve survival prospects more than ever before, body image adjustment is increasingly a central consideration in the care of burn-injured individuals. An appreciation that both physiological and psychosocial processes underpin such injuries is key to understanding wound healing. Perceptions of idealized body images in Western society challenge children and their families as they grow up with and adapt to disfigurement from burns...
2018: Burns and Trauma
Khaled Al-Tarrah, Martin Hewison, Naiem Moiemen, Janet M Lord
Vitamin D deficiency is common among the general population. It is also observed in up to 76% of critically ill patients. Despite the high prevalence of hypovitaminosis D in critical illness, vitamin D is often overlooked by medical staff as the clinical implications and consequences of vitamin D deficiency in acute contexts remain to be fully understood. Vitamin D has a broad range of pleotropic effects on various processes and systems including the immune-inflammatory response. 1α,25-dihydroxyvitamin D (1,25(OH)2 D), has been shown to promote a tolerogenic immune response limiting deleterious inflammatory effects, modulation of the innate immune system, and enhancement of anti-microbial peptides...
2018: Burns and trauma
Frank Li, Danielle Coombs
Background: A pre-morbid mental health history is common in patients with severe burn injuries. This creates challenges in providing rehabilitation. The aim of this study is to cross examine the possible impact of psychological co-morbidities on outcomes. Methods: A notes audit was carried out examining patients that were admitted to Concord Hospital Burns Unit in a 3-year period (2010-2012). Patients with total body surface area (TBSA) of 20% or greater and aged between 16 and 50 years were included...
2018: Burns and Trauma
Luís Cabral, Vera Afreixo, Rita Meireles, Miguel Vaz, Catarina Chaves, Marisa Caetano, Luís Almeida, José Artur Paiva
Background: Due to greater infection susceptibility, sepsis is the main cause of death in burn patients. Quick diagnosis and patient stratification, early and appropriated antimicrobial therapy, and focus control are crucial for patients' survival. On the other hand, superfluous extension of therapy is associated with adverse events and arousal of microbial resistance. The use of biomarkers, necessarily coupled with close clinical examination, may predict outcomes, stratifying patients who need more intensive care, and monitor the efficacy of antimicrobial therapy, allowing faster de-escalation or stop, reducing the development of resistance and possibly the financial burden, without increasing mortality...
2018: Burns and Trauma
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