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Burns and Trauma

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https://www.readbyqxmd.com/read/30003115/electrically-stimulated-cell-migration-and-its-contribution-to-wound-healing
#1
REVIEW
Guangping Tai, Michael Tai, Min Zhao
Naturally occurring electric fields are known to be morphogenetic cues and associated with growth and healing throughout mammalian and amphibian animals and the plant kingdom. Electricity in animals was discovered in the eighteenth century. Electric fields activate multiple cellular signaling pathways such as PI3K/PTEN, the membrane channel of KCNJ15/Kir4.2 and intracellular polyamines. These pathways are involved in the sensing of physiological electric fields, directional cell migration (galvanotaxis, also known as electrotaxis), and possibly other cellular responses...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29988731/review-of-additive-manufactured-tissue-engineering-scaffolds-relationship-between-geometry-and-performance
#2
REVIEW
Andrew Gleadall, Dafydd Visscher, Jing Yang, Daniel Thomas, Joel Segal
Material extrusion additive manufacturing has rapidly grown in use for tissue engineering research since its adoption in the year 2000. It has enabled researchers to produce scaffolds with intricate porous geometries that were not feasible with traditional manufacturing processes. Researchers can control the structural geometry through a wide range of customisable printing parameters and design choices including material, print path, temperature, and many other process parameters. Currently, the impact of these choices is not fully understood...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29942813/the-venous-ulcer-continues-to-be-a-clinical-challenge-an-update
#3
REVIEW
Ting Xie, Junna Ye, Kittipan Rerkasem, Rajgopal Mani
Venous ulcers are a common chronic problem in many countries especially in Northern Europe and USA. The overall prevalence of this condition is 1% rising to 3% in the over 65 years of age. Over the last 25 years, there have been many developments applicable to its diagnosis and treatment. These advances, notwithstanding healing response and recurrence, are variable, and the venous ulcer continues to be a clinical challenge. The pathogenesis of venous ulcers is unrelieved or ambulatory venous hypertension resulting mostly from deep venous thrombosis leading to venous incompetence, lipodermatosclerosis, leucocyte plugging of the capillaries, tissue hypoxia and microvascular dysfunction...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29942812/a-retrospective-cohort-study-to-compare-post-injury-admissions-for-infectious-diseases-in-burn-patients-non-burn-trauma-patients-and-uninjured-people
#4
Janine M Duke, Sean M Randall, James H Boyd, Mark W Fear, Suzanne Rea, Fiona M Wood
Background: Injury triggers a range of systemic effects including inflammation and immune responses. This study aimed to compare infectious disease admissions after burn and other types of injury using linked hospital admissions data. Methods: A retrospective longitudinal study using linked health data of all patients admitted with burns in Western Australia ( n  = 30,997), 1980-2012, and age and gender frequency matched cohorts of people with non-burn trauma ( n  = 28,647) and no injury admissions ( n  = 123,399)...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29930950/3d-printing-of-patient-specific-neck-splints-for-the-treatment-of-post-burn-neck-contractures
#5
Dafydd O Visscher, Sjoerd Te Slaa, Mariëlle E Jaspers, Marloes van de Hulsbeek, Jorien Borst, Jan Wolff, Tymour Forouzanfar, Paul P van Zuijlen
No abstract text is available yet for this article.
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29854856/cell-therapy-for-severe-burn-wound-healing
#6
REVIEW
Zhe Li, Peter Maitz
Cell therapy has emerged as an important component of life-saving procedures in treating burns. Over past decades, advances in stem cells and regenerative medicine have offered exciting opportunities of developing cell-based alternatives and demonstrated the potential and feasibility of various stem cells for burn wound healing. However, there are still scientific and technical issues that should be resolved to facilitate the full potential of the cellular devices. More evidence from large, randomly controlled trials is also needed to understand the clinical impact of cell therapy in burns...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29850643/epidemiologic-and-clinical-characteristics-of-severe-burn-patients-results-of-a-retrospective-multicenter-study-in-china-2011-2015
#7
Hao Tian, Liangxi Wang, Weiguo Xie, Chuanan Shen, Guanghua Guo, Jiaqi Liu, Chunmao Han, Licheng Ren, Yi Liang, Yong Tang, Yuan Wang, Meifang Yin, Jiaping Zhang, Yuesheng Huang
Background: Severe burns injury is a serious pathology, leading to teratogenicity and significant mortality, and it also has a long-term social impact. The aim of this article is to describe the hospitalized population with severe burns injuries in eight burn centers in China between 2011 and 2015 and to suggest future preventive strategies. Methods: This 5-year retrospective review included all patients with severe burns in a database at eight institutions. The data collected included gender, age, month distribution, etiology, location, presence of inhalation injury, total burn surface area, depth of the burn, the length of hospitalization, and mortality...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29796394/synthesis-of-graphene-oxide-quaternary-ammonium-nanocomposite-with-synergistic-antibacterial-activity-to-promote-infected-wound-healing
#8
Tengfei Liu, Yuqing Liu, Menglong Liu, Ying Wang, Weifeng He, Gaoqiang Shi, Xiaohong Hu, Rixing Zhan, Gaoxing Luo, Malcolm Xing, Jun Wu
Background: Bacterial infection is one of the most common complications in burn, trauma, and chronic refractory wounds and is an impediment to healing. The frequent occurrence of antimicrobial-resistant bacteria due to irrational application of antibiotics increases treatment cost and mortality. Graphene oxide (GO) has been generally reported to possess high antimicrobial activity against a wide range of bacteria in vitro . In this study, a graphene oxide-quaternary ammonium salt (GO-QAS) nanocomposite was synthesized and thoroughly investigated for synergistic antibacterial activity, underlying antibacterial mechanisms and biocompatibility in vitro and in vivo ...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29744373/body-image-in-paediatric-burns-a-review
#9
REVIEW
Ian C C King
Burn injuries in children can result in life-long disfigurement. As medical and surgical techniques of burn management improve survival prospects more than ever before, body image adjustment is increasingly a central consideration in the care of burn-injured individuals. An appreciation that both physiological and psychosocial processes underpin such injuries is key to understanding wound healing. Perceptions of idealized body images in Western society challenge children and their families as they grow up with and adapt to disfigurement from burns...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29721511/vitamin-d-status-and-its-influence-on-outcomes-following-major-burn-injury-and-critical-illness
#10
REVIEW
Khaled Al-Tarrah, Martin Hewison, Naiem Moiemen, Janet M Lord
Vitamin D deficiency is common among the general population. It is also observed in up to 76% of critically ill patients. Despite the high prevalence of hypovitaminosis D in critical illness, vitamin D is often overlooked by medical staff as the clinical implications and consequences of vitamin D deficiency in acute contexts remain to be fully understood. Vitamin D has a broad range of pleotropic effects on various processes and systems including the immune-inflammatory response. 1α,25-dihydroxyvitamin D (1,25(OH)2 D), has been shown to promote a tolerogenic immune response limiting deleterious inflammatory effects, modulation of the innate immune system, and enhancement of anti-microbial peptides...
2018: Burns and trauma
https://www.readbyqxmd.com/read/29637081/mental-health-history-a-contributing-factor-for-poorer-outcomes-in-burn-survivors
#11
Frank Li, Danielle Coombs
Background: A pre-morbid mental health history is common in patients with severe burn injuries. This creates challenges in providing rehabilitation. The aim of this study is to cross examine the possible impact of psychological co-morbidities on outcomes. Methods: A notes audit was carried out examining patients that were admitted to Concord Hospital Burns Unit in a 3-year period (2010-2012). Patients with total body surface area (TBSA) of 20% or greater and aged between 16 and 50 years were included...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29610766/checking-procalcitonin-suitability-for-prognosis-and-antimicrobial-therapy-monitoring-in-burn-patients
#12
Luís Cabral, Vera Afreixo, Rita Meireles, Miguel Vaz, Catarina Chaves, Marisa Caetano, Luís Almeida, José Artur Paiva
Background: Due to greater infection susceptibility, sepsis is the main cause of death in burn patients. Quick diagnosis and patient stratification, early and appropriated antimicrobial therapy, and focus control are crucial for patients' survival. On the other hand, superfluous extension of therapy is associated with adverse events and arousal of microbial resistance. The use of biomarkers, necessarily coupled with close clinical examination, may predict outcomes, stratifying patients who need more intensive care, and monitor the efficacy of antimicrobial therapy, allowing faster de-escalation or stop, reducing the development of resistance and possibly the financial burden, without increasing mortality...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29556507/assessment-and-prediction-of-road-accident-injuries-trend-using-time-series-models-in-kurdistan
#13
Maryam Parvareh, Asrin Karimi, Satar Rezaei, Abraha Woldemichael, Sairan Nili, Bijan Nouri, Nader Esmail Nasab
Background: Road traffic accidents are commonly encountered incidents that can cause high-intensity injuries to the victims and have direct impacts on the members of the society. Iran has one of the highest incident rates of road traffic accidents. The objective of this study was to model the patterns of road traffic accidents leading to injury in Kurdistan province, Iran. Methods: A time-series analysis was conducted to characterize and predict the frequency of road traffic accidents that lead to injury in Kurdistan province...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29556506/a-rare-case-of-severe-third-degree-friction-burns-and-large-morel-lavallee-lesion-of-the-abdominal-wall
#14
Darnell J Brown, Kuo Jung G Lu, Kristina Chang, Jennifer Levin, John T Schulz, Jeremy Goverman
Background: Morel-Lavallee lesions (MLLs) are rare internal degloving injuries typically caused by blunt traumatic injuries and most commonly occur around the hips and in association with pelvic or acetabular fractures. MLL is often overlooked in the setting of poly-trauma; therefore, clinicians must maintain a high degree of suspicion and be familiar with the management of such injuries, especially in obese poly-trauma patients. Case presentation: We present a 30-year-old female pedestrian struck by a motor vehicle who sustained multiple long bone fractures, a mesenteric hematoma, and full-thickness abdominal skin friction burn which masked a significant underlying abdominal MLL...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29497619/the-validation-study-on-a-three-dimensional-burn-estimation-smart-phone-application-accurate-free-and-fast
#15
A K W Cheah, T Kangkorn, E H Tan, M L Loo, S J Chong
Background: Accurate total body surface area burned (TBSAB) estimation is a crucial aspect of early burn management. It helps guide resuscitation and is essential in the calculation of fluid requirements. Conventional methods of estimation can often lead to large discrepancies in burn percentage estimation. We aim to compare a new method of TBSAB estimation using a three-dimensional smart-phone application named 3D Burn Resuscitation (3D Burn) against conventional methods of estimation-Rule of Palm, Rule of Nines and the Lund and Browder chart...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29404374/bioprinting-of-skin-constructs-for-wound-healing
#16
REVIEW
Peng He, Junning Zhao, Jiumeng Zhang, Bo Li, Zhiyuan Gou, Maling Gou, Xiaolu Li
Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. A potential solution to this problem is to fabricate skin constructs using biomaterial scaffolds with or without cells. Bioprinting is being applied to address the need for skin tissues suitable for transplantation, and can lead to the development of skin equivalents for wound healing therapy...
2018: Burns and trauma
https://www.readbyqxmd.com/read/29299483/validation-of-the-trauma-mortality-prediction-scores-from-a-malaysian-population
#17
Jih Huei Tan, Henry Chor Lip Tan, Nur Azlin Md Noh, Yuzaidi Mohamad, Rizal Imran Alwi
Background: Well-known trauma mortality prediction scores such as New Injury Severity Score (NISS), Revised Trauma Score (RTS), and Trauma and Injury Severity Score (TRISS) have been externally validated from high-income countries with established trauma databases. However, these scores were never used in Malaysian population. In this current study, we attempted to validate these scoring systems using our regional trauma surgery database. Methods: A retrospective analysis of the regional Malaysian Trauma Surgery Database was performed over a period of 3 years from May 2011 to April 2014...
2017: Burns and Trauma
https://www.readbyqxmd.com/read/29226160/the-significance-of-changes-in-platelet-concentration-during-the-early-phase-after-severe-burn-injury-in-a-chinese-mass-casualty
#18
Beiming Shou, Junqiang Li, Chenqi Tang, Qian Tan, Dongfeng Zheng, Binwei Sun, Lanjun Nie, Hongwei Zhang, Yanan Jiang, Chunming Wang, Yanwen Wu
Background: Changes in platelet concentration are common in severe burn patients. Platelets play a key role in the course of disease. This study aims to explore the significance of platelet concentration during the course of the disease in victims of a mass burn casualty. Methods: A total of 180 patients were involved in the "8.2" Kunshan explosion accident in China. The examined data included age, gender, total burn area (% TBSA), third-degree burn area (% TBSA), and platelet concentration within the first 5 days after the burn injury...
2017: Burns and Trauma
https://www.readbyqxmd.com/read/29214186/a-rare-case-of-failed-healing-in-previously-burned-skin-after-a-secondary-burns
#19
Stephen J Goldie, Shaun Parsons, Hana Menezes, Andrew Ives, Heather Cleland
Background: Patients presenting with large surface area burns are common in our practice; however, patients with a secondary large burn on pre-existing burn scars and grafts are rare and not reported. Case presentation: We report on an unusual case of a patient sustaining a secondary large burn to areas previously injured by a burn from a different mechanism. We discuss the potential implications when managing a case like this and suggest potential biological reasons why the skin may behave differently...
2017: Burns and trauma
https://www.readbyqxmd.com/read/29152518/follow-up-in-patients-with-a-burn-related-emergency-department-visit-a-feasibility-study
#20
H Goei, B F M Wijnen, S Mans, M A C de Jongh, C H van der Vlies, S Polinder, N E E van Loey, M E van Baar
Background: Data on epidemiology, costs, and outcomes of burn-related injuries presenting at emergency departments (EDs) are scarce. To obtain such information, a questionnaire study with an adequate response rate is imperative. There is evidence that optimized strategies can increase patient participation. However, it is unclear whether this applies to burn patients in an ED setting. The objective of this feasibility study was to optimize and evaluate patient recruitment strategy and follow-up methods in patients with burn injuries presenting at EDs...
2017: Burns and Trauma
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