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Eye and Vision (London, England)

Antonio Renna, Jorge Luciano Alió, Luis Felipe Vejarano
INTRODUCTION: Presbyopia affects people from the 4(th) decade of life and is characterized by accommodative loss that leads to negative effects on vision-targeted health-related quality of life. A non-invasive pharmacological treatment providing near-lenses independence would be a truly groundbreaking approach in the treatment of presbyopia. The purpose of this review is to analyze the emerging pharmacological solutions proposed to address presbyopia. RESULTS: Several ophthalmic eye drops compounds solutions have been described in peer-reviewed papers or presented in ophthalmological tabloids and congresses...
2017: Eye and Vision (London, England)
Georgios Labiris, Panagiota Ntonti, Maria Patsiamanidi, Haris Sideroudi, Kimon Georgantzoglou, Vassilios P Kozobolis
BACKGROUND: Pseudophakic presbyopic correction is among the prevalent methods for regaining near vision capacity. The purpose of this study is to compare the impact of pseudophakic monovision correction and multifocal lens implantation on the performance in a series of activities of daily living (ADL) of presbyopic patients. METHODS: An ADL research framework (10 ADLs) was constructed and validated in a sample of patients divided into three validation groups according to their near visual acuity...
2017: Eye and Vision (London, England)
Koushik Tripathy, Rohan Chawla, Kanhaiya Mittal, Rajni Farmania, Pradeep Venkatesh, Sheffali Gulati
BACKGROUND: Subacute sclerosing panencephalitis (SSPE) is a potentially fatal complication of measles. The authors report a case of recurrent myoclonic jerks under investigation, whose ophthalmic examination pointed to the diagnosis. CASE PRESENTATION: A 12-year-old boy with recurrent episodes of myoclonic jerks was found to have optic disc pallor and an irregular macular scar with pigmentation in the left eye. The retinal finding proved to be a strong diagnostic clue for SSPE...
2017: Eye and Vision (London, England)
Katie L Pennington, Margaret M DeAngelis
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in adults over 50 years old. Genetic, epidemiological, and molecular studies are beginning to unravel the intricate mechanisms underlying this complex disease, which implicate the lipid-cholesterol pathway in the pathophysiology of disease development and progression. Many of the genetic and environmental risk factors associated with AMD are also associated with other complex degenerative diseases of advanced age, including cardiovascular disease (CVD)...
2016: Eye and Vision (London, England)
Robert Edward T Ang, Emerson M Cruz, Alex U Pisig, Maria Luisa Patricia C Solis, Rosalie Mae M Reyes, Gerhard Youssefi
BACKGROUND: To evaluate the safety and effectiveness of the Supracor excimer laser algorithm to treat hyperopic presbyopic patients using laser in-situ keratomileusis (LASIK). METHODS: This is a retrospective case review of patients diagnosed with hyperopia (Sphere ≥ +0.0 D and presbyopia reading add ≥ 1.0 D) who underwent Supracor excimer laser treatment on at least one eye for presbyopia correction from year May 2011 to May 2013. Binocular vision was further analyzed after patients were subdivided into three groups: Group A (n = 22 eyes, 11 patients) had Supracor on both eyes; Group B (n = 18 eyes, 18 patients) had Supracor in one eye and hyperopic LASIK on fellow eye; and Group C (n = 29 eyes, 29 patients) had Supracor in one eye and no treatment on the fellow eye...
2016: Eye and Vision (London, England)
Elka Popova, Momchil Kostov, Petia Kupenova
BACKGROUND: Some data indicate that the dopaminergic and GABAergic systems interact in the vertebrate retina, but the type of interactions is not well understood. METHODS: In this study we investigated the effect of dopamine D1 receptor blockade by 75 μM SCH 23390 on the electroretinographic ON (b-wave) and OFF (d-wave) responses in intact frog eyecup preparations and in eyecups where the ionotropic GABA receptors were blocked by 50 μM picrotoxin. Student's t-test, One-way repeated measures ANOVA with Bonferroni post-hoc test and Two-way ANOVA were used for statistical evaluation of the data...
2016: Eye and Vision (London, England)
Almamoun Abdelkader, Herbert E Kaufman
BACKGROUND: To test and compare in a masked fashion the efficacy of using a parasympathomimetic drug (3% carbachol) and an alpha-2 agonist (0.2% brimonidine) in both combined and separate forms to create optically beneficial miosis to pharmacologically improve vision in presbyopia. METHODS: A prospective, double-masked, randomized, controlled clinical trial was conducted. Ten naturally emmetropic and presbyopic subjects between 42 and 58 years old with uncorrected distance visual acuity of at least 20/20 in both eyes without additional ocular pathology were eligible for inclusion...
2016: Eye and Vision (London, England)
James M Stringham, Kevin J O'Brien, Nicole T Stringham
BACKGROUND: The so-called macular carotenoids (MC) lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) comprise the diet-derived macular pigment (MP). The purpose of this study was to determine effects of MC supplementation on the optical density of MP (MPOD), repeated-exposure photostress recovery (PSR), and disability glare (DG) thresholds. METHODS: This was a double-blind, placebo-controlled trial. Fifty-nine young (mean age = 21.7), healthy volunteers participated in this study...
2016: Eye and Vision (London, England)
Wolfgang Radner
Presbyopia correction is mainly concerned with the goal of regaining an uncorrected reading performance. Since historic reading charts do not provide a unique standard that is applicable for the analysis of clinical and scientific reading performance, new standardized reading charts have been developed, in order to provide reading performance analyses analogous to modern single-optotype distance acuity measurements: the Bailey-Lovie Word Reading Chart, the Colenbrander English Continuous Text Near Vision Cards, the MNREAD Charts, and the RADNER Reading Charts...
2016: Eye and Vision (London, England)
Pipat Kongsap
BACKGROUND: Cataract surgery is the most common surgical procedure in ophthalmology. Biometry data and accurate intraocular lens (IOL) calculations are very important in achieving the desired refractive outcomes. The aim of this study was to compare measurements using a new optical low coherence reflectometry (OLCR) biometer (OA-2000) and the gold standard partial coherence interferometry (PCI) optical biometer (IOLMaster 500). METHODS: Ocular biometry of cataract patients were measured by the OA-2000 and IOLMaster 500 to compare keratometry (K), axial length (AL), anterior chamber depth (ACD), white-to-white (WTW) diameter, and IOL power using the SRK/T formula...
2016: Eye and Vision (London, England)
Samir S Shoughy, Igor Kozak
The current field of posterior pole and retinal imaging of the human eye has expanded into detailed analyses of the macula, retinal periphery, individual retinal layers, vitreoretinal interface, imaging of the choroid and the optic nerve head. The challenge in retinal imaging is the enduring pursuit of deeper penetration into tissues, increased resolution to the cellular level, and interpretation of observations. How much deeper can we go and with what resolution and reproducibility? These are fundamental questions for experts in search of novel imaging modalities...
2016: Eye and Vision (London, England)
Selam Yekta Sendul, Cemile Ucgul Atilgan, Semra Tiryaki, Dilek Guven
BACKGROUND: To present a female child patient with osteogenesis imperfecta who had bilateral papilledema. CASE PRESENTATION: A twelve-year-old girl with osteogenesis imperfecta was referred to our clinic. Bilateral best corrected visual acuity of the patient was 5/10 (corrected with +3.50 for right eye, +5.00 for left eye) with a standard Snellen scale at a distance of a 6 m. Anterior chamber, iris and lens examination of both of her eyes were unremarkable. In her fundus examination, bilateral stage 2 papilledema and the wrinkles in papillomacular area were noticed...
2016: Eye and Vision (London, England)
Anirbaan Mukherjee, Richard A Bone
BACKGROUND: Cataract, a leading cause of vision impairment, is due to the lens becoming excessively optically dense. Change in the lens optical density (LOD) could be a useful indicator of incipient nuclear cataract and would necessitate the development of accurate measurement techniques. Mapcat sf™ is a heterochromatic flicker photometer for measuring macular pigment optical density (MPOD) under photopic conditions. In the process, it also measures LOD that is needed in the calculation of MPOD...
2016: Eye and Vision (London, England)
Pradeep Venkatesh, Rohan Chawla, Koushik Tripathy, Harsh Inder Singh, Ravi Bypareddy
BACKGROUND: Effective therapeutic options are limited for the management of chronic central serous chorioretinopathy (CSCR) complicated by exudative retinal detachments (RD). The authors describe the resolution of one such case following partial thickness scleral resection with mitomycin C. CASE PRESENTATION: This 39-year-old male presented with a unilateral inferior exudative RD in the right eye. There was no history of steroid use either locally or systemically...
2016: Eye and Vision (London, England)
Swaminathan Sethu, Rohit Shetty, Kalyani Deshpande, Natasha Pahuja, Nandini Chinnappaiah, Aarti Agarwal, Anupam Sharma, Arkasubhra Ghosh
BACKGROUND: Vitamin D deficiency is associated with a range of systemic diseases including ocular disorders. The objective of this study is to measure tear vitamin D levels and investigate the correlation between serum and tear vitamin D levels. METHODS: A total of 48 healthy volunteers without any systemic and ocular disease were recruited for this observational cohort study. Serum was collected using clot activator coated Vacutainer® Plus tubes. Tear fluid was collected using Schirmer's strips...
2016: Eye and Vision (London, England)
Charles Whitford, Akram Joda, Steve Jones, Fangjun Bao, Paolo Rama, Ahmed Elsheikh
BACKGROUND: The eye globe exhibits significant regional variation of mechanical behaviour. The aim of this present study is to develop a new experimental technique for testing intact eye globes in a form that is representative of in vivo conditions, and therefore suitable for determining the material properties of the complete outer ocular tunic. METHODS: A test rig has been developed to provide closed-loop control of either applied intra-ocular pressure or resulting apical displacement; measurement of displacements across the external surface of the eye globe using high-resolution digital cameras and digital image correlation software; prevention of rigid-body motion and protection of the ocular surface from environmental drying...
2016: Eye and Vision (London, England)
Krishnatej Nishtala, Natasha Pahuja, Rohit Shetty, Rudy M M A Nuijts, Arkasubhra Ghosh
Keratoconus is a progressive corneal thinning, ectatic condition, which affects vision. Recent advances in corneal topography measurements has helped advance proper diagnosis of this condition and increased research and clinical interests in the disease etiopathogenesis. Considerable progress has been achieved in understanding the progression of the disease and tear fluid has played a major role in the progress. This review discusses the importance of tear fluid as a source of biomarker for keratoconus and how advances in technology have helped map the complexity of tears and thereby molecular readouts of the disease...
2016: Eye and Vision (London, England)
Anastasios John Kanellopoulos, George Asimellis
BACKGROUND: Femtosecond-laser assisted clear cornea cataract surgery may hold promise in safer and more effective procedures. We decided to perform a comparative study to standard manual incision phacoemulsification surgery. METHODS: This is a single-center, single-intervention, and prospective comparative data evaluation of 133 consecutive cases subjected to cataract surgery. Group-A (Phaco), manual capsulorhexis & ultrasound phacoemulsification (n = 66); Group-B femtosecond-laser assisted capsulorhexis and lens fragmentation (n = 67), employing the LenSx laser (Alcon Surgical, Ft...
2016: Eye and Vision (London, England)
FangJun Bao, Brendan Geraghty, QinMei Wang, Ahmed Elsheikh
Keratoconus is a bilateral, non-inflammatory, degenerative corneal disease. The occurrence and development of keratoconus is associated with corneal thinning and conical protrusion, which causes irregular astigmatism. With the disruption of the collagen organization, the cornea loses its shape and function resulting in progressive visual degradation. Currently, corneal topography is the most important tool for the diagnosis of keratoconus, which may lead to false negatives among the patient population in the subclinical phase...
2016: Eye and Vision (London, England)
Carisa Mariella Alvarez Paraz, Ha Thi Thu Truong, Darren Kyauk Sai, Howard Yu Cajucom-Uy, Cherry Lay Li Chan, Selina Md Kassim
BACKGROUND: To assess the knowledge of Singaporean youth regarding corneal donation and gauge their willingness to donate their corneas. METHODS: We conducted a cross-sectional study among 500 students from five tertiary institutions in Singapore. All students answered self-administered questionnaires which included seven questions that tested knowledge and three questions that determined willingness to donate corneas. RESULTS: Among 500 Singaporean youth aged 18 to 25, most students (73...
2016: Eye and Vision (London, England)
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