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Eye and Vision (London, England)

Patrick B Rapuano, Priya M Mathews, George J Florakis, Stephen L Trokel, Leejee H Suh
Background: Corneal collagen crosslinking (CXL) is a widely used treatment for halting the progression of keratoconus. Although initial studies of CXL were performed with a riboflavin solution containing dextran, recent protocols for CXL have indicated the use of a riboflavin solution containing isotonic hydroxypropyl methylcellulose (HPMC). This study was performed to investigate differences in visual outcomes and Scheimpflug (Pentacam) analysis in patients who have undergone epithelium-off CXL with riboflavin solution containing either 20% dextran versus 1...
2018: Eye and Vision (London, England)
Giovana Rosa Gameiro, Hong Jiang, Yi Liu, Yuqing Deng, Xiaoyan Sun, Bernardo Nascentes, Bernard Baumel, Tatjana Rundek, Jianhua Wang
Background: It remains unknow whether retinal tissue perfusion occurs in patients with Alzheimer's disease. The goal was to determine retinal tissue perfusion in patients with clinical Alzheimer's disease (CAD). Methods: Twenty-four CAD patients and 19 cognitively normal (CN) age-matched controls were recruited. A retinal function imager (RFI, Optical Imaging Ltd., Rehovot, Israel) was used to measure the retinal blood flow supplying the macular area of a diameter of 2...
2018: Eye and Vision (London, England)
Daniel Su, Sunir Garg
Background: The Retinal Function Imager (RFI) provides in vivo and noninvasive imaging of both the retinal structure and function. Review: The RFI can create capillary perfusion maps, measure blood flow velocity, and determine metabolic function including blood oximetry. It can aid clinical diagnosis as well as assess treatment response in several retinal vascular diseases including diabetic retinopathy. Blood flow velocity abnormalities have also been implicated in disease such as age-related macular degeneration and require further investigation...
2018: Eye and Vision (London, England)
Fupeng Wang, Qinqin Zhang, Anthony J Deegan, Jun Chang, Ruikang K Wang
Background: There are two forms of system implementation of optical coherence tomography angiography (OCTA) in ophthalmic imaging, i.e., spectral domain (SD-) and swept source OCTA (SS-OCTA). The purpose of this paper is to compare the SD-OCTA and SS-OCTA for elucidating structural and vascular features associated with central serous retinopathy (CSR), and to evaluate the effects of CSR on SD- and SS-OCTA's imaging capabilities. Methods: Normal subjects and CSR patients were imaged by SD- and SS-OCTA using 3 × 3 mm and 6 × 6 mm scan patterns...
2018: Eye and Vision (London, England)
Giacomo Savini, Kenneth J Hoffer
Background: This review aims to explain the reasons why intraocular lens (IOL) power calculation is challenging in eyes with previous corneal refractive surgery and what solutions are currently available to obtain more accurate results. Review: After IOL implantation in eyes with previous LASIK, PRK or RK, a refractive surprise can occur because i) the altered ratio between the anterior and posterior corneal surface makes the keratometric index invalid; ii) the corneal curvature radius is measured out of the optical zone; and iii) the effective lens position is erroneously predicted if such a prediction is based on the post-refractive surgery corneal curvature...
2018: Eye and Vision (London, England)
Megh D Patel, Fareshta Khushzad, Heather E Moss
Background: Optic nerve head measurements extracted from optical coherence tomography (OCT) show promise for monitoring clinical conditions with elevated optic nerve heads. The aim of this study is to compare reliability within and between raters and between image acquisition devices of optic nerve measurements derived from OCT scans in eyes with varying degrees of optic nerve elevation. Methods: Wide angle line scans and narrow angle radial scans through optic nerve heads were obtained using three spectral domain(SD) OCT devices on 5 subjects (6 swollen optic nerves, 4 normal optic nerves)...
2018: Eye and Vision (London, England)
Yilei Shao, Aizhu Tao, Hong Jiang, Meixiao Shen, Dexi Zhu, Fan Lu, Carol L Karp, Yufeng Ye, Jianhua Wang
Background: Spectral domain optical coherence tomography (SD-OCT) was a useful tool to study accommodation in human eye, but the maximum image depth is limited due to the decreased signal-to-noise ratio (SNR). In this study, improving optical resolutions, speeds and the SNR were achieved by custom built SD-OCT, and the evaluation of the impact of the improvement during accommodation was investigated. Methods: Three systems with different spectrometer designs, including two Charge Coupled Device (CCD) cameras and one Complementary Metal-Oxide-Semiconductor Transistor (CMOS) camera, were tested...
2018: Eye and Vision (London, England)
Marie-Bénédicte Rougier, Mélanie Le Goff, Jean-François Korobelnik
Background: The differential diagnosis of optic disc edema at the acute phase can be challenging. OCT angiography (OCTA) is a new technology allowing the visualization of the peripapillary vascular network and optic disc capillaries. The peripapillary network alterations of glaucoma and chronic non-arteritic anterior ischemic optic neuropathy (NAION) were reported. However, no OCTA studies on acute optic disc edema from various causes. The aim of this project was to use OCTA to demonstrate the vascular changes the optic nerve head of various types of optic disc edema at the acute phase...
2018: Eye and Vision (London, England)
Hong Jiang, Wan Chen, Silvia Delgado, Yi Liu, Ying Lin, Jianhua Wang
Background: The retina has been used to study the pathophysiology of multiple sclerosis (MS). Peripapillary retinal nerve fiber layer (pRNFL) thinning has been suggested as an ocular biomarker of neurodegeneration in MS. The goal of this project was to determine the birefringence of the pRNFL by measuring the fiber birefringence using polarization sensitive optical coherence tomography (PS-OCT). Methods: Sixty-six MS patients without history of optic neuritis (age: 39...
2018: Eye and Vision (London, England)
Nandini Venkateswaran, Anat Galor, Jianhua Wang, Carol L Karp
The advent of optical coherence tomography (OCT) imaging has changed the way ophthalmologists image the ocular surface and anterior segment of the eye. Its ability to obtain dynamic, high and ultra-high resolution, cross-sectional images of the ocular surface and anterior segment in a noninvasive and rapid manner allows for ease of use. In this review, we focus on the use of anterior segment OCT, which provides an "optical biopsy" or in vivo imaging of various ocular surface and corneal pathologies, allowing the clinician to diagnose diseases otherwise not visualized by traditional methods...
2018: Eye and Vision (London, England)
António Queirós, Ana Amorim-de-Sousa, Daniela Lopes-Ferreira, César Villa-Collar, Ángel Ramón Gutiérrez, José Manuel González-Méijome
Background: To characterize the axial and off-axis refraction across four meridians of the retina in myopic eyes before and after Orthokeratology (OK) and LASIK surgery. Methods: Sixty right eyes with a spherical equivalent (M) between - 0.75 to - 5.25 D (cylinder <- 1.00 D) underwent LASIK (n = 26) or OK (n = 34) to treat myopia. Axial and off-axis refraction were measured with an open-field autorefractometer before and after stabilized treatments. Off-axis measurements were obtained for the horizontal (35° nasal and temporal retina) and vertical (15° superior and inferior retina) meridians, and for two oblique directions (45-225° and 135-315°) up to 20° of eccentricity...
2018: Eye and Vision (London, England)
Liang Wang, Olwen Murphy, Natalia Gonzalez Caldito, Peter A Calabresi, Shiv Saidha
Purpose: To review the clinical and research value of optical coherence tomography angiography (OCTA) in the field of neurology. Methods: Current literature involving OCTA were reviewed through PubMed using the search terms "optical coherence tomography angiography", with "multiple sclerosis", "Alzheimer's disease", "optic neuropathy", or other closely-related terms. Results: OCTA has been applied in research to advance our understanding of the pathobiology of neurological disorders...
2018: Eye and Vision (London, England)
Bahram Eshraghi, Hadi Ghadimi, Zohreh Nozarian
Background: Hemangiopericytoma and solitary fibrous tumor are considered related variants on the same spectrum and both may essentially be the same tumor. They are infrequently encountered in the orbital region while the zygomatic bone is an extremely rare location for these neoplasms to occur. Case presentation: A 14-year-old boy presented with complaint of deformity of left infraorbital area and a firm, regular mass in the region. Orbital CT scan revealed a well-defined round isodense intraosseous lesion in the lowermost portion of the lateral orbital wall (zygomatic bone), expanding the bone and protruding anteriorly and medially...
2018: Eye and Vision (London, England)
Richard N McNeely, Salissou Moutari, Eric Pazo, Jonathan E Moore
Background: To investigate the impact of the orientation of preoperative corneal astigmatism on achieving the postoperative target refraction following monofocal intraocular lens (IOL) implantation. Methods: This study enrolled 339 eyes who had uneventful cataract surgery or refractive lens exchange (RLE) with subsequent monofocal IOL implantation. Eyes were initially categorized dependent upon axial length and then on the orientation of preoperative anterior corneal astigmatism...
2018: Eye and Vision (London, England)
Jean-Claude Mwanza, Joshua L Warren, Donald L Budenz
Optical coherence tomography (OCT) has moved to the forefront of imaging modalities in the management of glaucoma and retinal diseases. It is modifying how glaucoma and glaucoma progression are diagnosed clinically and augmenting our understanding of the disease. OCT provides multiple parameters from various anatomic areas for glaucoma diagnosis, evaluation of treatment efficacy, and progression monitoring. While the use of multiple parameters has increased the likelihood of detecting early structural changes, diagnosing glaucoma in early stages is often challenging when the damages are subtle and not apparent on OCT scans, in addition to the fact that assessment of OCT parameters often yields conflicting findings...
2018: Eye and Vision (London, England)
Robert Edward Ty Ang, Michelle Marie Salcedo Quinto, Emerson Marquez Cruz, Mark Christian Reyes Rivera, Gladness Henna Austria Martinez
Background: To compare femtosecond laser-assisted versus conventional phacoemulsification in terms of visual and refractive outcomes, cumulative dissipated energy, anterior chamber inflammation and endothelial cell loss. Methods: In this retrospective cohort study, records of eyes that underwent femtosecond laser-assisted cataract surgery (FLACS) or conventional phacoemulsification (CP) were reviewed. The Victus femtosecond laser (Bausch and Lomb, Germany) was used to carry out corneal incisions, anterior capsulotomy, and lens fragmentation in FLACS procedures...
2018: Eye and Vision (London, England)
John S M Chang
Background: Astigmatic keratotomy (AK) remains an accessible means to correct surgically induced or naturally occurring astigmatism. The advantages of femtosecond laser-assisted astigmatic keratotomy (FSAK) over conventional methods have been recognized recently. Main text: This review evaluates the efficacy, complications, and different methods of FSAK for correction of astigmatism in native eyes and those that underwent previous penetrating keratoplasty (PKP)...
2018: Eye and Vision (London, England)
Jiaojie Chen, Wei Huang, Rong Zhu, Jun Jiang, Yiyu Li
Background: This retrospective study was designed to investigate the sole influence of orthokeratology (OK) lens fitting decentration on the Zernike coefficients of the reshaped anterior corneal surface. Methods: This study comprised a review of 106 right eyes and measurements of corneal topography both before OK and at 1-month follow-up visit. A routine was designed to calculate local corneal surface astigmatism and assist the determination of OK lens fitting decentration from pupil center...
2018: Eye and Vision (London, England)
AnnMarie Hipsley, Brad Hall, Karolinne M Rocha
Presbyopia corrections traditionally have been approached with attempts to exchange power, either at the cornea or the lens planes, inducing multifocality, or altering asphericity to impact the optical system. Treatments that affect the visual axis, such as spectacle and contact lens correction, refractive surgeries, corneal onlays and inlays, and intraocular lenses are typically unable to restore true accommodation to the presbyopic eye. Their aim is instead to enhance 'pseudoaccommodation' by facilitating an extended depth-of-focus for which vision is sufficient...
2018: Eye and Vision (London, England)
Samuel Arba Mosquera, Diego de Ortueta, Shwetabh Verma
Background: In this retrospective randomized case series, we compared bilateral symmetry between OD and OS eyes, intercorneal differences and Functional Optical Zone (FOZ) of the corneal aberrations. Methods: Sixty-seven normal subjects (with no ocular pathology) who never had any ocular surgery were bilaterally evaluated at Augenzentrum Recklinghausen (Germany). In all cases, standard examinations and corneal wavefront topography (OPTIKON Scout) were performed...
2018: Eye and Vision (London, England)
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