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Progress in Biomaterials

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https://www.readbyqxmd.com/read/30242739/development-of-a-pcl-gelatin-chitosan-%C3%AE-tcp-electrospun-composite-for-guided-bone-regeneration
#1
Masoumeh Ezati, Hamide Safavipour, Behzad Houshmand, Shahab Faghihi
Many approaches have been developed to regenerate biological substitutes for repairing damaged tissues. Guided bone/tissue regeneration (GBR/GTR) that employs a barrier membrane has received much attention in recent years. Regardless of substantial efforts for treatment of damaged tissue in recent years, an effective therapeutic strategy is still a challenge for tissue engineering researchers. The aim of the current study is to fabricate a GBR membrane consisting of polycaprolactone (PCL)/gelatin/chitosan which is modified with different percentages of β-tricalcium phosphate (β-TCP) for improved biocompatibility, mechanical properties, and antibacterial activity...
September 21, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/30242738/formulation-and-evaluation-of-curcumin-microsponges-for-oral-and-topical-drug-delivery
#2
Meenakshi Bhatia, Megha Saini
The aim of the present study was to improve the release rate of curcumin by microsponges prepared through quasi-emulsion solvent diffusion technique using ethylcellulose and PVA as carriers. The microsponges were characterized by FTIR, DSC, XRD and SEM studies followed by determination of total drug content and entrapment efficiency. The prepared microsponges were further filled in hard gelatin capsule shell and then loaded in carbopol gel to evaluate its potential in oral and topical drug delivery. Further, it was observed from the studies on release rate that microsponges filled in hard gelatin capsule shells (batch MS4) showed 93...
September 21, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/30203125/cardiovascular-stents-overview-evolution-and-next-generation
#3
REVIEW
Setareh Borhani, Shadi Hassanajili, Seyed Hossein Ahmadi Tafti, Shahram Rabbani
Compared to bare-metal stents (BMSs), drug-eluting stents (DESs) have been regarded as a revolutionary change in coronary artery diseases (CADs). Releasing pharmaceutical agents from the stent surface was a promising progress in the realm of cardiovascular stents. Despite supreme advantages over BMSs, in-stent restenosis (ISR) and long-term safety of DESs are still deemed ongoing concerns over clinically application of DESs. The failure of DESs for long-term clinical use is associated with following factors including permanent polymeric coating materials, metallic stent platforms, non-optimal drug releasing condition, and factors that have recently been supposed as contributory factors such as degradation products of polymers, metal ions due to erosion and degradation of metals and their alloys utilizing in some stents as metal frameworks...
September 10, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/30182344/cellulose-based-hydrogel-materials-chemistry-properties-and-their-prospective-applications
#4
REVIEW
S M Fijul Kabir, Partha P Sikdar, B Haque, M A Rahman Bhuiyan, A Ali, M N Islam
Hydrogels based on cellulose comprising many organic biopolymers including cellulose, chitin, and chitosan are the hydrophilic material, which can absorb and retain a huge proportion of water in the interstitial sites of their structures. These polymers feature many amazing properties such as responsiveness to pH, time, temperature, chemical species and biological conditions besides a very high-water absorption capacity. Biopolymer hydrogels can be manipulated and crafted for numerous applications leading to a tremendous boom in research during recent times in scientific communities...
September 4, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/30173382/diabetes-can-change-the-viscoelastic-properties-of-lymphocytes
#5
N Parvanehpour, Shahrokh Shojaei, S Khorramymehr, V Goodarzi, F Hejazi, V Faghihi Rezaei
Mechanical properties of the cells are among the most highlighted area of interests among researchers for decades. Not only many of the cells' crucial functional characteristics such as adherence to the cellular substrate, migration abilities and morphological factors are directly influenced by their mechanical properties but also changes in these traits could have importance in diagnosis and even treatments of some serious diseases. The general mechanical properties of the cells are associated with some intercellular characteristics such as arrangement and organization of the actin fibers and cytoskeleton architecture...
September 1, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/30141130/tailoring-the-gelatin-chitosan-electrospun-scaffold-for-application-in-skin-tissue-engineering-an-in-vitro-study
#6
Mohamad Pezeshki-Modaress, Mojgan Zandi, Sarah Rajabi
The nanofibrous structure containing protein and polysaccharide has good potential in tissue engineering. The present work aims to study the role of chitosan in gelatin/chitosan nanofibrous scaffolds fabricated through electrospinning process under optimized condition. The performance of chitosan in gelatin/chitosan nanofibrous scaffolds was evaluated by mechanical tests, scanning electron microscopy (SEM), Fourier transform infrared (FTIR) and in vitro cell culture on scaffolds with different gelatin/chitosan blend ratios...
August 23, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/30022467/chitosan-polyethylene-glycol-fumarate-blend-films-for-wound-dressing-application-in-vitro-biocompatibility-and-biodegradability-assays
#7
Azadehsadat Hashemi Doulabi, Hamid Mirzadeh, Mohammad Imani, Shadab Bagheri-Khoulenjani
Blending is one of the effective approaches in preparing tailored materials with a wide range of properties. Thus, chitosan-based polymers have been fabricated and used as wound dressings since they possess better properties than those of the constituent materials. The objective of this work was to evaluate the biocompatibility and biodegradability of biodegradable blend films based on polyethylene glycol-co-fumarate (PEGF) and chitosan (Ch). The blend films of Ch/PEGF were prepared by solution casting/solvent evaporation method...
June 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/30019188/allogenic-vs-synthetic-granules-for-bone-tissue-engineering-an-in-vitro-study
#8
Farnaz Kouhestani, Farnaz Dehabadi, Mehrnoosh Hasan Shahriari, Saeed Reza Motamedian
The aim of this study was to compare human dental pulp stem cells' (DPSCs) attachment, proliferation and osteogenic differentiation on allogenic and synthetic biphasic bone granules. In this in vitro study, two types of bone granules were used: allograft [freeze-dried bone allograft (FDBA)] and biphasic granules [hydroxyapatite/beta-tricalcium phosphate (HA/β-TCP)]. By isolation of DPSCs, their attachment to bone granules was observed by scanning electron microscope (SEM) at day 1 and 7 of cultivation. Vital cells were measured by MTT assay at 1, 3, and 7 days of cell culture...
June 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29790132/updates-on-the-research-and-development-of-absorbable-metals-for-biomedical-applications
#9
REVIEW
Hendra Hermawan
Absorbable metals, metals that corrode in physiological environment, constitute a new class of biomaterials intended for temporary medical implant applications. The introduction of these metals has shifted the established paradigm of metal implants from preventing corrosion to its direct application. Interest toward absorbable metals has been growing in the past decade. This is proved by the rapid increase in scientific publication, progressive development of standards, and launching the first commercial products...
June 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29785538/stress-phase-angle-regulates-differentiation-of-human-adipose-derived-stem-cells-toward-endothelial-phenotype
#10
Shahrokh Shojaei, Mohammad Tafazzoli-Shadpour, Mohammad Ali Shokrgozar, Nooshin Haghighipour, Fatemeh Hejazi Jahromi
Endothelial cells are subjected to cyclic shear by pulsatile blood flow and pressures due to circumferential stresses. Although most of the researches on this topic have considered the effects of these two biomechanical forces separately or concurrently, few studies have noticed the interaction of these cyclic loadings on endothelial behavior. Negative temporal stress phase angle, defined by the phase lag between cyclic shear and tensile stresses, is an established parameter which is known to have substantial effects on blood vessel remodeling and progression of some serious cardiovascular diseases...
June 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29748742/effect-of-bioactive-glass-nanoparticles-on-biological-properties-of-plga-collagen-scaffold
#11
Samira Nokhasteh, Alireza Sadeghi-Avalshahr, Amir Mahdi Molavi, Mohammad Khorsand-Ghayeni, Hojjat Naderi-Meshkin
Bioactive glasses have shown some interesting biological properties such as biocompatibility, biodegradation, and angiogenesis in skin tissue engineering. In the current research, the effects of MgO- or CoO-doped 64S bioactive glass with a composition of 64 SiO2 -26 CaO-5 P2 O5 -5 MgO or CoO (mol%) were studied in relation with biological properties of electrospun [poly(lactic-co-glycolic acid) (PLGA)/collagen]. PLGA/collagen samples were rinsed in suspension of bioactive glass nanoparticles in distilled water with a concentration of 0...
June 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29627953/correction-to-solidification-of-hydatid-cyst-fluid-with-an-injectable-chitosan-carboxymethylcellulose-%C3%AE-glycerophosphate-hydrogel-for-effective-control-of-spillage-during-aspiration-of-hydatid-cysts
#12
Mostafa D A Azadi, Shadi Hassanajili, Khalil Zarrabi, Bahador Sarkari
The original version of this article unfortunately contained a mistake: the spelling of the Shadi Hassanajili's name was incorrect. The corrected name is given above.
June 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29754201/skin-bioprinting-a-novel-approach-for-creating-artificial-skin-from-synthetic-and-natural-building-blocks
#13
Robin Augustine
Significant progress has been made over the past few decades in the development of in vitro-engineered substitutes that mimic human skin, either as grafts for the replacement of lost skin, or for the establishment of in vitro human skin models. Tissue engineering has been developing as a novel strategy by employing the recent advances in various fields such as polymer engineering, bioengineering, stem cell research and nanomedicine. Recently, an advancement of 3D printing technology referred as bioprinting was exploited to make cell loaded scaffolds to produce constructs which are more matching with the native tissue...
May 12, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29460181/immunoisolation-of-stem-cells-by-simultaneous-encapsulation-and-pegylation
#14
Roya Ramezanzadeh Andevari, Sameereh Hashemi-Najafabadi, Fatemeh Bagheri
Today, cell therapy is known as an important tool in the treatment of chronic diseases where cells lose their normal function. Immunoisolation systems using microencapsulation or PEGylation have been developed to evade the problem of rejection by the immune system. The aim of the present study was to investigate a combination of microencapsulation and PEGylation methods in coating mouse embryonic stem cells (mESCs) to determine its effect in reducing the host's immune response. Therefore, methoxy polyethylene glycol (mPEG) binding on alginate-trimethyl chitosan (TMC) microcapsules was investigated using FTIR...
March 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29460180/solidification-of-hydatid-cyst-fluid-with-an-injectable-chitosan-carboxymethylcellulose-%C3%AE-glycerophosphate-hydrogel-for-effective-control-of-spillage-during-aspiration-of-hydatid-cysts
#15
Mostafa D A Azadi, Shadi Hassanjili, Khalil Zarrabi, Bahador Sarkari
Cystic echinococcosis (CE)/hydatid cyst is one of the most important helminthic diseases in the world. The treatment of hydatid cyst ranges from surgical intervention to chemotherapy, although the efficacy of chemotherapy is still unclear. Postoperative complication which results from the spillage of cysts during surgical operation is one of the most important concerns in surgical treatment of hydatid cyst. The aim of the current study was to solidify the hydatid cyst fluid (HCF) with an injectable and thermosensitive chitosan (CS)/carboxymethyl cellulose (CMC)/β-glycerol phosphate (BGP) hydrogel for effective control of spillage during the aspiration of hydatid cysts...
March 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29446015/synthetic-polymeric-biomaterials-for-wound-healing-a-review
#16
Mariam Mir, Murtaza Najabat Ali, Afifa Barakullah, Ayesha Gulzar, Munam Arshad, Shizza Fatima, Maliha Asad
Wounds are of a variety of types and each category has its own distinctive healing requirements. This realization has spurred the development of a myriad of wound dressings, each with specific characteristics. It is unrealistic to expect a singular dressing to embrace all characteristics that would fulfill generic needs for wound healing. However, each dressing may approach the ideal requirements by deviating from the 'one size fits all approach', if it conforms strictly to the specifications of the wound and the patient...
March 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29428997/synthesis-of-zeolite-membranes-on-calcium-silicate-support-and-their-bioactive-response
#17
A Medina-Ramírez, A A Flores-Díaz, B Ruiz Camacho, G García-Ruiz
The synthesis of calcium silicate supported zeolite membrane was carried out by second growth method. The chemical nature of the functionalizing agent on the formation of homogenous zeolite membrane was evaluated. One monomer and two cationic polymers were used: 3-aminopropyltriethoxysilane (APS), polyethylenimine (PEI) and polydiallyldimethylammonium chloride (PDDA). The support was subjected to chemical functionalization and then it was rubbed with zeolite crystals. The W zeolite was used as zeolite seed in two different Si/Al ratios...
March 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29363004/correction-to-cure-kinetic-study-of-methacrylate-poss-copolymers-for-ocular-lens
#18
F Shokrolahi, M Zandi, P Shokrollahi, M Atai, E Gafar-Zadeh, M Hanifeh
The original version of this article unfortunately contained a mistake: the spelling of the Ebrahim Gafar-Zadehs' name was incorrect. The corrected name is given above.
March 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29363003/correction-to-compositional-design-and-taguchi-optimization-of-hardness-properties-in-silicone-based-ocular-lenses
#19
Mohammad Hanifeh, Mojgan Zandi, Parvin Shokrollahi, Mohammad Atai, Ebrahim Gafar-Zadeh, Fahimeh Askari
The original version of this article unfortunately contained a mistake: The spelling of the Ebrahim Gafar-Zadehs' name was incorrect. The corrected name is given above.
March 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29196898/fabrication-of-curcumin-loaded-electrospun-nanofiberous-polyurethanes-with-anti-bacterial-activity
#20
A Shababdoust, M Ehsani, P Shokrollahi, M Zandi
Two series of polyurethane (PU), based on polycaprolactone (PCL) as soft segments with two different molecular weights (2000 and 530 Da), and hexamethylene diisocyanate (HDI) and 1,4-butandiol (BDO) as hard segments were synthesized to fabricate curcumin-loaded electrospun nanofibrous PCL-based PU substrate. Chemical structures of the synthesized PUs were characterized by FTIR and NMR spectroscopy techniques. The thermal properties were analyzed by differential scanning calorimetry (DSC) and surface hydrophilicity was studied by static contact angle and bulk hydrophilicity was evaluated by water uptake test...
March 2018: Progress in Biomaterials
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