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European Clinical Respiratory Journal

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https://www.readbyqxmd.com/read/27900930/availability-of-pulmonary-rehabilitation-in-primary-care-for-patients-with-copd-a-cross-sectional-study-in-sweden
#1
Mats Arne, Margareta Emtner, Karin Lisspers, Karin Wadell, Björn Ställberg
BACKGROUND: Pulmonary rehabilitation (PR) is an important, evidence-based component for the management of individuals with chronic obstructive pulmonary disease (COPD). In daily practice, the majority of COPD patients are treated in primary care. However, information about the availability of PR in primary care in Sweden is lacking. The aim was to investigate the availability of rehabilitation resources in primary care settings for patients with COPD in Sweden. METHODS: A cross-sectional descriptive design was applied, using web-based questionnaires sent to all primary care centres in four regions, comprising more than half of the 9...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27890047/a-clear-urban-rural-gradient-of-allergic-rhinitis-in-a-population-based-study-in-northern-europe
#2
Stine Holmegaard Christensen, Signe Timm, Christer Janson, Bryndis Benediktsdóttir, Bertil Forsberg, Mathias Holm, Rain Jogi, Ane Johannessen, Ernst Omenaas, Torben Sigsgaard, Cecilie Svanes, Vivi Schlünssen
BACKGROUND: The protective effect of farm upbringing on allergic rhinitis is well known, but how upbringing in other environments influences the development of allergic rhinitis is scarcely investigated. The aim of this study was to investigate the association between place of upbringing and pet keeping in childhood and allergic rhinitis and nasal symptoms in adulthood. METHODS: The population-based Respiratory Health in Northern Europe study includes subjects from Denmark, Norway, Sweden, Iceland, and Estonia born in 1945-1973...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27839531/complications-and-discomfort-of-bronchoscopy-a-systematic-review
#3
REVIEW
Elise Orvedal Leiten, Einar Marius Hjellestad Martinsen, Per Sigvald Bakke, Tomas Mikal Lind Eagan, Rune Grønseth
OBJECTIVE: To identify bronchoscopy-related complications and discomfort, meaningful complication rates, and predictors. METHOD: We conducted a systematic literature search in PubMed on 8 February 2016, using a search strategy including the PICO model, on complications and discomfort related to bronchoscopy and related sampling techniques. RESULTS: The search yielded 1,707 hits, of which 45 publications were eligible for full review. Rates of mortality and severe complications were low...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27834178/the-danish-national-database-for-asthma-establishing-clinical-quality-indicators
#4
REVIEW
Susanne Hansen, Benjamin Hoffmann-Petersen, Asger Sverrild, Elvira V Bräuner, Jesper Lykkegaard, Uffe Bodtger, Lone Agertoft, Lene Korshøj, Vibeke Backer
Asthma is one of the most common chronic diseases worldwide affecting more than 300 million people. Symptoms are often non-specific and include coughing, wheezing, chest tightness, and shortness of breath. Asthma may be highly variable within the same individual over time. Although asthma results in death only in extreme cases, the disease is associated with significant morbidity, reduced quality of life, increased absenteeism, and large costs for society. Asthma can be diagnosed based on report of characteristic symptoms and/or the use of several different diagnostic tests...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27834177/swedish-translation-and-linguistic-validation-of-the-multidimensional-dyspnoea-profile
#5
Magnus Ekström, Josefin Sundh
BACKGROUND: Dyspnoea, the feeling of breathing discomfort, consists of multiple dimensions that can vary in intensity, including the level of unpleasantness, qualities or descriptors of the sensation, emotional responses, and impact on function. No validated instrument for multidimensional measurement of dyspnoea is available in Swedish. The Multidimensional Dyspnea Profile (MDP) was recently developed to measure the unpleasantness, sensory qualities, and emotional responses of dyspnoea across diseases and settings...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27834176/primary-pulmonary-adenocarcinoma-in-a-16-year-old-boy-a-five-year-follow-up
#6
Ane Stillits Måreng, Seppo W Langer, Uffe Bodtger
Primary pulmonary adenocarcinoma in children or adolescents is a rare disease, and as such, there are no randomised studies on lung cancer for this age group. Treatment choice is extrapolated from studies in adults (mean age of participants: 60 years). We present the 5-year follow-up of a 16-year-old boy who presented with metastatic primary pulmonary adenocarcinoma (T3N3M1a) and was treated aggressively, including radiation therapy for local and distant recurrence. He had complete remission, had completed his education, was employed full-time, and suffered only from mild side effects to treatment...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27834175/severe-asthma-anti-ige-or-anti-il-5
#7
REVIEW
Evgenia Papathanassiou, Stelios Loukides, Petros Bakakos
Severe asthma is a discrete clinical entity characterised by recurrent exacerbations, reduced quality of life and poor asthma control as ordinary treatment regimens remain inadequate. Difficulty in managing severe asthma derives partly from the multiple existing phenotypes and our inability to recognise them. Though the exact pathogenetic pathway of severe allergic asthma remains unclear, it is known that numerous inflammatory cells and cytokines are involved, and eosinophils represent a key inflammatory cell mediator...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27814780/music-does-not-alter-anxiety-in-patients-with-suspected-lung-cancer-undergoing-bronchoscopy-a-randomised-controlled-trial
#8
Elisabeth Jeppesen, Carsten M Pedersen, Klaus R Larsen, Anne Rehl, Karen Bartholdy, Emil S Walsted, Vibeke Backer
BACKGROUND: The use of music to relieve anxiety has been examined in various studies, but the results are inconclusive. METHODS: From April to October 2015, 160 patients undergoing examination of pulmonary nodules were randomly assigned to MusiCure or no music. MusiCure was administered through earplugs to ensure blinding of the staff and was played from admission to the operating theatre to the end of the bronchoscopy. Spielberger's State-Trait Anxiety Inventory (STAI) was administered on admission, immediately before bronchoscopy, and on discharge...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27733234/airflow-limitation-as-a-risk-factor-for-low-bone-mineral-density-and-hip-fracture
#9
Trine Herland, Ellen M Apalset, Geir Egil Eide, Grethe S Tell, Sverre Lehmann
AIM: To investigate whether airflow limitation is associated with bone mineral density (BMD) and risk of hip fractures. METHODS: A community sample of 5,100 subjects 47-48 and 71-73 years old and living in Bergen was invited. Participants filled in questionnaires and performed a post-bronchodilator spirometry measuring forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC). All attendants were invited to have a BMD measurement of the hip. During 10 years of follow-up, information on death was collected from the Norwegian Cause of Death Registry, and incident hip fractures were registered from regional hospital records of discharge diagnoses and surgical procedure codes...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27683028/disseminated-lung-cancer-presenting-as-a-rectal-mass
#10
Mia M Noergaard, Inger M H Stamp, Uffe Bodtger
Primary lung cancer is the leading cause of cancer-related deaths globally, and approximately 50% had metastatic disease at the time of diagnosis. A rectal mass and unintended weight loss are common manifestations of rectal cancer. Our case presented with a rectal mass, but workup revealed a metastatic lesion from lung cancer. Lung cancer metastases to the lower gastrointestinal tract imply reduced survival compared with the already poor mean survival of stage IV lung cancer. Despite relevant therapy, the patient died 5 months after referral...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27616539/pirfenidone-treatment-in-idiopathic-pulmonary-fibrosis-nationwide-danish-results
#11
Goran Nadir Salih, Saher Burhan Shaker, Helle Dall Madsen, Elisabeth Bendstrup
BACKGROUND: Pirfenidone was approved by the European Medicines Agency and introduced in most European countries in 2011 for treatment of idiopathic pulmonary fibrosis (IPF). OBJECTIVE: To describe the national Danish experiences of pirfenidone treatment for IPF during 30 months with respect to target population, safety, adherence to the treatment and effect analysis in a well-characterised IPF population in a real-life setting. METHODS: Retrospective data collection from medical records of all patients in Denmark with IPF from 2011 to 2014...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27608271/prolonged-partial-upper-airway-obstruction-during-sleep-an-underdiagnosed-phenotype-of-sleep-disordered-breathing
#12
REVIEW
Ulla Anttalainen, Mirja Tenhunen, Ville Rimpilä, Olli Polo, Esa Rauhala, Sari-Leena Himanen, Tarja Saaresranta
Obstructive sleep apnea syndrome (OSAS) is a well-recognized disorder conventionally diagnosed with an elevated apnea-hypopnea index. Prolonged partial upper airway obstruction is a common phenotype of sleep-disordered breathing (SDB), which however is still largely underreported. The major reasons for this are that cyclic breathing pattern coupled with arousals and arterial oxyhemoglobin saturation are easy to detect and considered more important than prolonged episodes of increased respiratory effort with increased levels of carbon dioxide in the absence of cycling breathing pattern and repetitive arousals...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27608270/prevalence-of-abnormal-findings-when-adopting-new-national-and-international-global-lung-function-initiative-reference-values-for-spirometry-in-the-finnish-general-population
#13
Annette Kainu, Ari Lindqvist, Anssi R A Sovijärvi
BACKGROUND: New Finnish (Kainu2015) and international Global Lung Function Initiative (GLI2012) reference values for spirometry were recently published. The aim of this study is to compare the interpretative consequences of adopting these new reference values with older, currently used Finnish reference values (Viljanen1982) in the general population of native Finns. METHODS: Two Finnish general population samples including 1,328 adults (45% males) aged 21-74 years were evaluated...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27608269/a-new-removable-airway-stent
#14
Tore Amundsen, Sveinung Sørhaug, Håkon Olav Leira, Stig Sverre Tyvold, Thomas Langø, Tommy Hammer, Frode Manstad-Hulaas, Erney Mattsson
BACKGROUND: Malignant airway obstruction is a feared complication and will most probably occur more frequently in the future because of increasing cancer incidence and increased life expectancy in cancer patients. Minimal invasive treatment using airway stents represents a meaningful and life-saving palliation. We present a new removable airway stent for improved individualised treatment. METHODS: To our knowledge, the new airway stent is the world's first knitted and uncovered self-expanding metal stent, which can unravel and be completely removed...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27600696/change-in-pulmonary-diffusion-capacity-in-a-general-population-sample-over-9-years
#15
Michael L Storebø, Tomas M L Eagan, Geir E Eide, Amund Gulsvik, Einar Thorsen, Per S Bakke
RATIONALE: Data on the change in diffusion capacity of the lung for carbon monoxide (DLCO) over time are limited. We aimed to examine change in DLCO (ΔDLCO) over a 9-year period and its predictors. METHODS: A Norwegian community sample comprising 1,152 subjects aged 18-73 years was examined in 1987 and 1988. Of the 1,109 subjects still alive, 830 (75%) were re-examined in 1996/97. DLCO was measured with the single breath-holding technique. Covariables recorded at baseline included sex, age, height, weight, smoking status, pack years, occupational exposure, educational level, and spirometry...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27534614/no-change-in-prevalence-of-symptoms-of-copd-between-1996-and-2006-in-finnish-adults-a-report-from-the-finess-helsinki-study
#16
Annette Kainu, Paula Pallasaho, Anne Pietinalho
BACKGROUND: The age-dependent increase of chronic obstructive pulmonary disease (COPD) prevalence caused by smoking and other inhalational exposures in the general population is well-known worldwide. However, time trends are poorly known, due to lower number of high-quality studies especially following nationwide efforts on diminishing exposure levels. This study aimed to compare the prevalence of COPD symptoms and their major determinants in Finnish adults in 1996 and 2006. METHODS: Two identical postal surveys were conducted among two random population samples from Helsinki using identical methodologies in 1996 and 2006, with 6,062 (76%) and 2,449 (62%) participants, respectively...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27478030/nt-probnp-95-ng-l-can-exclude-pulmonary-hypertension-on-echocardiography-at-diagnostic-workup-in-patients-with-interstitial-lung-disease
#17
Charlotte Andersen, Søren Mellemkjær, Ole Hilberg, Elisabeth Bendstrup
BACKGROUND: Pulmonary hypertension (PH) is a serious complication to interstitial lung disease (ILD) and has a poor prognosis. PH is often diagnosed by screening with echocardiography followed by right heart catheterisation. A previous study has shown that a value of NT-pro-brain natriuretic peptide (NT-proBNP) <95 ng/l could be used to rule out PH in patients with ILD. AIM: To evaluate this rule-out test for PH in a new cohort of incident patients with ILD. METHODS: An established database with data from 148 consecutive patients referred from January 2012 to October 2014 was used to identify patients and obtain data from echocardiography, NT-proBNP, diagnosis and lung function...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27435431/a-retrospective-chart-review-of-pirfenidone-treated-patients-in-sweden-the-repris-study
#18
Carl Magnus Sköld, Christer Janson, Åsa Klackenberg Elf, Marie Fiaschi, Kerstin Wiklund, Hans Lennart Persson
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease that usually results in respiratory failure and death. Pirfenidone was approved as the first licensed therapy for IPF in Europe based on phase III trials where patients with a forced vital capacity (FVC) >50% of predicted were included. The aim of this study was to characterise patients treated with pirfenidone in Swedish clinical practice and to describe the adherence to the reimbursement restriction since reimbursement was only applied for patients with FVC below 80% of predicted...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27421833/sputum-rna-signature-in-allergic-asthmatics-following-allergen-bronchoprovocation-test
#19
Rob G J A Zuiker, Catherine Tribouley, Zuzana Diamant, J Diderik Boot, Adam F Cohen, K Van Dyck, I De Lepeleire, Veronica M Rivas, Vladislav A Malkov, Jacobus Burggraaf, Marcella K Ruddy
BACKGROUND: Inhaled allergen challenge is a validated disease model of allergic asthma offering useful pharmacodynamic assessment of pharmacotherapeutic effects in a limited number of subjects. OBJECTIVES: To evaluate whether an RNA signature can be identified from induced sputum following an inhaled allergen challenge, whether a RNA signature could be modulated by limited doses of inhaled fluticasone, and whether these gene expression profiles would correlate with the clinical endpoints measured in this study...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27421832/chronic-bronchitis-in-west-sweden-a-matter-of-smoking-and-social-class
#20
Malin Axelsson, Linda Ekerljung, Jonas Eriksson, Stig Hagstad, Eva Rönmark, Jan Lötvall, Bo Lundbäck
BACKGROUND: Although chronic bronchitis is associated with impaired quality of life, hospitalisations and increased mortality, it has been less in focus after the introduction of the term chronic obstructive pulmonary disease (COPD). There are no recent published data on the prevalence of chronic bronchitis from the Scandinavian countries. AIM: The main aim of the present study was to estimate the prevalence of chronic bronchitis in West Sweden by using data from a large-scale epidemiological study of the general population...
2016: European Clinical Respiratory Journal
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