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European Clinical Respiratory Journal

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https://www.readbyqxmd.com/read/29887979/determinants-of-persistent-asthma-in-young-adults
#1
Lisbet Krogh Traulsen, Anders Halling, Jesper Bælum, Jesper Rømhild Davidsen, Martin Miller, Øyvind Omland, David Sherson, Torben Sigsgaard, Trine Thilsing, Gert Thomsen, Lars Rauff Skadhauge
Objective: The aim of the study was to evaluate determinants for the prognosis of asthma in a population-based cohort of young adults. Design: The study was a nine-year clinical follow up of 239 asthmatic subjects from an enriched population-based sample of 1,191 young adults, aged 20-44 years, who participated in an interviewer-administered questionnaire and clinical examination at baseline in 2003-2006. From the interview, an asthma score was generated as the simple sum of affirmative answers to five main asthma-like symptoms in order to analyse symptoms of asthma as a continuum...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29785256/job-titles-classified-into-socioeconomic-and-occupational-groups-identify-subjects-with-increased-risk-for-respiratory-symptoms-independent-of-occupational-exposure-to-vapour-gas-dust-or-fumes
#2
Christian Schyllert, Martin Andersson, Linnea Hedman, Magnus Ekström, Helena Backman, Anne Lindberg, Eva Rönmark
Objectives : To evaluate the ability of three different job title classification systems to identify subjects at risk for respiratory symptoms and asthma by also taking the effect of exposure to vapours, gas, dust, and fumes (VGDF) into account. Background : Respiratory symptoms and asthma may be caused by occupational factors. There are different ways to classify occupational exposure. In this study, self-reported occupational exposure to vapours, gas, dust and fumes was used as well as job titles classifed into occupational and socioeconomic Groups according to three different systems...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29785255/feasibility-of-high-intensity-training-in-asthma
#3
L L Toennesen, E D Soerensen, M Hostrup, C Porsbjerg, J Bangsbo, V Backer
Background: High-intensity interval training is an effective and popular training regime but its feasibility in untrained adults with asthma is insufficiently described. Objective: The randomized controlled trial 'EFFORT Asthma' explored the effects of behavioural interventions including high-intensity interval training on clinical outcomes in nonobese sedentary adults with asthma. In this article we present a sub analysis of data aiming to evaluate if patients' pre-intervention levels of asthma control, FEV1, airway inflammation and airway hyperresponsiveness (AHR) predicted their training response to the high-intensity interval training program, measured as increase in maximal oxygen consumption (VO2 max)...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29696083/health-care-resource-utilization-and-characteristics-of-patients-with-eosinophilic-asthma-in-secondary-health-care-in-finland
#4
Mika J Mäkelä, Helene Nordahl Christensen, Antti Karlsson, Sarang Rastogi, Kirsi Kettunen
Background : Eosinophilic airway inflammation is common in asthma patients and appears to be associated with severe exacerbations and loss of asthma control. Objective : To describe the resource utilization and clinical characteristics of patients with eosinophilic asthma. Design : Asthma patients ≥18 years with ≥1 blood eosinophil count in secondary care (South West Finland) during 2003‒2013 were included. Clinical characteristics (age, lung function, body mass index, and comorbidities) and asthma-related resource utilization (hospital admissions, outpatient visits, and emergency room [ER] visits) were retrieved...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29696082/oxidant-status-iron-homeostasis-and-carotenoid-levels-of-copd-patients-with-advanced-disease-and-ltot
#5
M Kentson, P Leanderson, P Jacobson, H L Persson
Background : The pathogenesis of chronic obstructive pulmonary disease (COPD) is associated with oxidative stress. Both iron (Fe) and oxygen are involved in the chemical reactions that lead to increased formation of reactive oxygen species. Oxidative reactions are prevented by antioxidants such as carotenoids. Objective : To study the differences in Fe status, carotenoid levels, healthy eating habits, and markers of inflammation and oxidative damage on proteins in subjects with severe COPD ± long-term oxygen therapy (LTOT) and lung-healthy control subjects...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29535852/nordic-consensus-statement-on-the-systematic-assessment-and-management-of-possible-severe-asthma-in-adults
#6
REVIEW
Celeste Porsbjerg, Charlotte Ulrik, Tina Skjold, Vibeke Backer, Birger Laerum, Sverre Lehman, Crister Janson, Thomas Sandstrøm, Leif Bjermer, Barbro Dahlen, Bo Lundbäck, Dora Ludviksdottir, Unnur Björnsdóttir, Alan Altraja, Lauri Lehtimäki, Paula Kauppi, Jussi Karjalainen, Hannu Kankaanranta
Although a minority of asthma patients suffer from severe asthma, they represent a major clinical challenge in terms of poor symptom control despite high-dose treatment, risk of exacerbations, and side effects. Novel biological treatments may benefit patients with severe asthma, but are expensive, and are only effective in appropriately targeted patients. In some patients, symptoms are driven by other factors than asthma, and all patients with suspected severe asthma ('difficult asthma') should undergo systematic assessment, in order to differentiate between true severe asthma, and 'difficult-to-treat' patients, in whom poor control is related to factors such as poor adherence or co-morbidities...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29321831/changes-in-smoking-prevalence-and-cessation-support-and-factors-associated-with-successful-smoking-cessation-in-swedish-patients-with-asthma-and-copd
#7
Marcus Stegberg, Mikael Hasselgren, Scott Montgomery, Karin Lisspers, Björn Ställberg, Christer Janson, Josefin Sundh
Introduction : Our aim was to investigate changes in smoking prevalence, smoking cessation support and factors associated with successful smoking cessation in patients with asthma and COPD. Methods : Questionnaires about available smoking cessation resources were completed by 54 primary health-care centers and 14 hospitals in central Sweden in 2005 and 2012. Patient data were collected using record reviews and patients questionnaires for two cohorts of randomly selected asthma and COPD patients in 2005 ( n  = 2306; with a follow up in 2012), and in 2014/2015 ( n  = 2620)...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29707170/tracheal-collapse-diagnosed-by-multidetector-computed-tomography-evaluation-of-different-image-analysis-methods
#8
Mette Nygaard, Elisabeth Bendstrup, Ronald Dahl, Ole Hilberg, Finn Rasmussen
Background : The gold standard for diagnosing excessive tracheal collapse is still evaluation during bronchoscopy. Today, multidetector computed tomography (MDCT) is used to confirm a suspicion of abnormal tracheal collapse. There is no gold standard for computed tomography (CT) image analysis of tracheal collapse. Purpose : To evaluate four different methods for the diagnosis of tracheal collapse using the images obtained through MDCT to help clinicians evaluate the images in daily practice. Objectives : 374 consecutive high-resolution CT scans with full inspiratory and end-expiratory CT scans were retrospectively analyzed...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29296255/from-copd-epidemiology-to-studies-of-pathophysiological-disease-mechanisms-challenges-with-regard-to-study-design-and-recruitment-process-respiratory-and-cardiovascular-effects-in-copd-kolin
#9
Anne Lindberg, Robert Linder, Helena Backman, Jonas Eriksson Ström, Andreas Frølich, Ulf Nilsson, Eva Rönmark, Viktor Johansson Strandkvist, Annelie F Behndig, Anders Blomberg
Background : Chronic obstructive pulmonary disease (COPD) is a largely underdiagnosed disease including several phenotypes. In this report, the design of a study intending to evaluate the pathophysiological mechanism in COPD in relation to the specific phenotypes non-rapid and rapid decline in lung function is described together with the recruitment process of the study population derived from a population based study. Method : The OLIN COPD study includes a population-based COPD cohort and referents without COPD identified in 2002-04 ( n  = 1986), and thereafter followed annually since 2005...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29230274/factors-influencing-pharmacological-treatment-in-copd-a-comparison-of-2005-and-2014
#10
Josefin Sundh, Joakim Åberg, Mikael Hasselgren, Scott Montgomery, Björn Ställberg, Karin Lisspers, Christer Janson
Introduction : The aim was to investigate how the pattern of pharmacological treatment in Swedish patients with chronic obstructive pulmonary disease (COPD) has changed over a decade, and to identify factors associated with treatment. Methods : Data on patient characteristics and pharmacological treatment were collected using questionnaires from two separate cohorts of randomly selected primary and secondary care patients with a doctor's diagnosis of COPD in central Sweden, in 2005 ( n  = 1111) and 2014 ( n  = 1329)...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29201290/ergospirometry-with-concurrent-fibre-optic-laryngoscopy-a-randomised-crossover-study
#11
Kiran Kafila Mirza, Emil Schwarz Walsted, Vibeke Backer
Background : Patients suffering from exercise-induced laryngeal obstruction (EILO) are subjected to several exhausting tests. We aimed to assess the feasibility of using a single test to obtain diagnostic measurements for maximum oxygen uptake (VO2 max) and exercise-induced laryngeal obstruction (EILO). Methods : Patients referred to the outpatient respiratory clinic at the University Hospital of Bispebjerg, Copenhagen with exercise-induced dyspnoea were evaluated for inclusion over 13 months. Eligible patients were aged 18-43 years, had a known EILO diagnosis (moderate or severe) and were inactive (self-reported activity) with less than 3 hours activity per week...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29201289/evaluation-of-clinical-variables-according-to-follow-up-times-in-copd-results-from-on-sint-cohort
#12
José Luis López-Campos, Alberto Fernández-Villar, Cristina Represas Represas, Lucía Marín Barrera, Maribel Botana Rial, Cecilia López Ramírez, Ricard Casamor
Background : COPD is a chronic disease traditionally associated with increased symptoms as lung function deteriorates. Follow-up times in previous cohort studies were limited to a few years. Interestingly, newer longer observational studies show a more comprehensive picture on disease progression over time. Therefore, the question on the relevancy of the follow-up time in cohort studies remains open. Methods : The ON-SINT study is an observational, retrospective, nationwide, real-life cohort study, in which patients diagnosed with COPD were recruited between December 2011 and April 2013 by primary care (PC) and secondary care (SC) physicians...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29057065/targeting-the-small-airways-with-dry-powder-adenosine-a-challenging-concept
#13
Erica van der Wiel, Anne J Lexmond, Maarten van den Berge, Dirkje S Postma, Paul Hagedoorn, Henderik W Frijlink, Martijn P Farenhorst, Anne H de Boer, Nick H T Ten Hacken
Background : Small-particle inhaled corticosteroids (ICS) provide a higher small airway deposition than large-particle ICS. However, we are still not able to identify asthma patients who will profit most from small-particle treatment. Objective : We aimed to identify these patients by selectively challenging the small and large airways. We hypothesized that the airways could be challenged selectively using small- and large-particle adenosine, both inhaled at a high and a low flow rate. Design : In this cross-over study 11 asthma subjects performed four dry powder adenosine tests, with either small (MMAD 2...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28815007/appropriate-selection-for-omalizumab-treatment-in-patients-with-severe-asthma
#14
Leo Nygaard, Daniel Pilsgaard Henriksen, Hanne Madsen, Jesper Rømhild Davidsen
Background : Omalizumab improves asthma control in patients with uncontrolled severe allergic asthma; however, appropriate patient selection is crucial. Information in this field is sparse. Objective : We aimed to estimate whether potential omalizumab candidates were appropriately selected according to guidelines, and the clinical effect of omalizumab treatment over time. Design : We performed a retrospective observational study on adult patients with asthma treated with omalizumab during 2006-2015 at the Department of Respiratory Medicine at Odense University Hospital (OUH), Denmark...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28815006/biomarkers-in-inflammometry-pediatric-asthma-utility-in-daily-clinical-practice
#15
REVIEW
Silvia Sánchez-García, Alicia Habernau Mena, Santiago Quirce
Asthma is a common disease in both high and lower income countries that starts early and persists often for life. A correct and accurate diagnosis, treatment and follow-up during childhood are essential for a better understanding of adult asthma and avoiding over- or under-treatment. Th2 inflammation in children with asthma symptoms is usually assessed by measuring with serum total IgE, blood eosinophilia and FeNO levels that may help to predict asthma, particularly in those infants and young children in whom lung function tests are difficult to perform...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28815005/phase-i-study-evaluating-the-safety-tolerability-and-pharmacokinetics-of-a-novel-oral-dissolvable-film-containing-dexamethasone-versus-fortecortin-dexamethasone-tablets
#16
Zuzana Diamant, Gabriella Samuelsson Palmgren, Bengt Westrin, Leif Bjermer
Introduction: Systemic corticosteroids are anti-inflammatory agents with dexamethasone among the most potent in the class. Within (respiratory) allergy, systemic corticosteroids are usually applied in medical emergencies. In these situations, patients may experience physical or logistic problems taking tablets. To fulfil a practical unmet need for outpatients, Dexa ODF, an oral dissolvable film containing dexamethasone, was developed. Objectives: We compared the safety, tolerability and pharmacokinetics (PK) of Dexa ODF with Fortecortin tablets in healthy subjects...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28815004/hypersensitivity-pneumonitis-among-wind-musicians-an-overlooked-disease
#17
Janne Møller, Charlotte Hyldgaard, Sissel Brix Kronborg-White, Finn Rasmussen, Elisabeth Bendstrup
Hypersensitivity pneumonitis (HP) is a complex pulmonary disorder mediated by the immune system and caused by various inhaled antigens against which the subject has previously been sensitized. In about 50% of the cases, the antigen is not identified. Identification and removal of the eliciting antigen is important for the prognosis. We report two cases of HP caused by molds and atypical mycobacteria isolated from wind instruments. We present the first case of HP caused by bassoon playing and another case of HP caused by molds in a trombone...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28680543/a-population-based-cohort-of-adults-with-asthma-mortality-and-participation-in-a-long-term-follow-up
#18
Helena Backman, Linnea Hedman, Caroline Stridsman, Sven-Arne Jansson, Anne Lindberg, Bo Lundbäck, Eva Rönmark
Background and objective: Asthma is a major public health concern. The aim of this study was to characterize a large population-based cohort of adults with asthma, and to study factors associated with all-cause mortality and non-participation in a long-term follow-up. Design: Random and stratified samples from five population-based cohorts were clinically examined during 1986-2001, and all subjects with asthma were included in the study (n = 2055, age 19-72 years, 55% women). Independent associations between different risk factors and (i) mortality and (ii) non-participation in a clinical follow-up in 2012-2014 were estimated...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28649311/screening-tools-for-evaluation-of-depression-in-chronic-obstructive-pulmonary-disease-copd-a-systematic-review
#19
K Bock, E Bendstrup, O Hilberg, A Løkke
Background: Anxiety and depression are common comorbid disorders in patients with chronic obstructive pulmonary disease (COPD), though estimates of their prevalence vary considerably. Depressive symptoms/depression are important comorbidities in COPD and an increasing interest is shown to these disorders. Depression may lead to reduced quality of life and increased morbidity and mortality. These statements underline the importance of implementing the use of screening instruments for depressive symptoms in a clinical setting...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28649310/lung-ultrasound-has-limited-diagnostic-value-in-rare-cystic-lung-diseases-a-cross-sectional-study
#20
Jesper Rømhild Davidsen, Elisabeth Bendstrup, Daniel P Henriksen, Ole Graumann, Christian B Laursen
Background: Lung ultrasound (LUS) used to identify interstitial syndrome (IS) and pleural thickening related to diffuse parenchymal lung disease (DPLD) has shown significant correlations with ground glass opacity (GGO) on high-resolution computed tomography (HRCT). However, the applicability of LUS in patients with DPLD subtypes as rare cystic lung diseases has not previously been investigated. This study aimed to observe if distinctive LUS findings could be found in patients with lymphangioleiomyomatosis (LAM), pulmonary Langerhans cell histiocytosis (PLCH), and Birt-Hogg-Dubé syndrome (BHDS)...
2017: European Clinical Respiratory Journal
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