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JOURNAL ARTICLE
Yunfei Pan, Mengjie Hu, Feimin Zhao, Jingjing Ren
OBJECTIVES: The primary aim of this study is to discern the association between specific clinical parameters and low muscle mass (LMM). We endeavor to elucidate the determinants of LMM and the predictive potency of individual factors. METHODS: In this retrospective cross-sectional study, we encompassed 450 older adult Chinese participants (252 males and 198 females). Muscle mass quantifications were performed using bioelectrical impedance analysis. Comprehensive data encompassing demographic details (age, sex, height, and weight) and laboratory results (complete blood count, thyroid function, liver function, and renal function) were systematically recorded...
March 2024: Osteoporosis and Sarcopenia
#2
JOURNAL ARTICLE
Worapong Sucharitpongpan
OBJECTIVES: The World Health Organization developed the Fracture Risk Assessment Tool (FRAX) to assess the risk of having fragility fractures in the next 10 years. The FRAX tool is different by country, race, gender, and age. This study is a community-based study aiming to identify the optimal cut-off values of FRAX for the identification of older individuals who are at high risk of osteoporosis fractures in both genders. METHODS: This cross-sectional, analytic study was conducted by using health screening data of the older adults aged 60-90 living in the 3 biggest districts of Nan province, Thailand...
March 2024: Osteoporosis and Sarcopenia
#3
JOURNAL ARTICLE
Huy G Nguyen, Hoa T Nguyen, Linh T T Nguyen, Thach S Tran, Lan T Ho-Pham, Sai H Ling, Tuan V Nguyen
OBJECTIVES: Vertebral fracture is both common and serious among adults, yet it often goes undiagnosed. This study aimed to develop a shape-based algorithm (SBA) for the automatic identification of vertebral fractures. METHODS: The study included 144 participants (50 individuals with a fracture and 94 without a fracture) whose plain thoracolumbar spine X-rays were taken. Clinical diagnosis of vertebral fracture (grade 0 to 3) was made by rheumatologists using Genant's semiquantitative method...
March 2024: Osteoporosis and Sarcopenia
#4
JOURNAL ARTICLE
Keisuke Uemura, Kazuma Takashima, Ryo Higuchi, Sotaro Kono, Hirokazu Mae, Makoto Iwasa, Hirohito Abe, Yuki Maeda, Takayuki Kyo, Takashi Imagama, Wataru Ando, Takashi Sakai, Seiji Okada, Hidetoshi Hamada
OBJECTIVES: Diagnosis and treatment of osteoporosis are instrumental in obtaining good outcomes of hip surgery. Measuring bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA) is the gold standard for diagnosing osteoporosis. However, due to limited access to DXA, there is a need for a screening tool to identify patients at a higher risk of osteoporosis. We analyzed the potential utility of the Osteoporosis Self-assessment Tool for Asians (OSTA) as a screening tool for osteoporosis...
March 2024: Osteoporosis and Sarcopenia
#5
EDITORIAL
Daisuke Inoue
No abstract text is available yet for this article.
March 2024: Osteoporosis and Sarcopenia
#6
JOURNAL ARTICLE
Min Woo Kim, Young Min Noh, Jung Wook Huh, Han Eol Seo, Dong Ha Lee
OBJECTIVES: This research delves into the application of texture analysis in spine computed tomography (CT) scans and its correlation with bone mineral density (BMD), as determined by dual-energy X-ray absorptiometry (DXA). It specifically addresses the discordance between the 2 measurements, suggesting that certain spinal-specific factors may contribute to this discrepancy. METHODS: The study involved 405 cases from a single institution collected between May 6, 2012 and June 30, 2021...
March 2024: Osteoporosis and Sarcopenia
#7
JOURNAL ARTICLE
Shigeharu Tanaka, Ryo Tanaka, Hungu Jung, Shunsuke Yamashina, Yu Inoue, Kazuhiko Hirata, Kai Ushio, Yasunari Ikuta, Yukio Mikami, Nobuo Adachi
OBJECTIVES: Clinical prediction rules are used to discriminate patients with locomotive syndrome and may enable early detection. This study aimed to validate the clinical predictive rules for locomotive syndrome in community-dwelling older adults. METHODS: We assessed the clinical prediction rules for locomotive syndrome in a cross-sectional setting. The age, sex, and body mass index of participants were recorded. Five physical function tests-grip strength, single-leg standing time, timed up-and-go test, and preferred and maximum walking speeds-were measured as predictive factors...
March 2024: Osteoporosis and Sarcopenia
#8
REVIEW
Ta-Wei Tai, Hsuan-Yu Chen, Chien-An Shih, Chun-Feng Huang, Eugene McCloskey, Joon-Kiong Lee, Swan Sim Yeap, Ching-Lung Cheung, Natthinee Charatcharoenwitthaya, Unnop Jaisamrarn, Vilai Kuptniratsaikul, Rong-Sen Yang, Sung-Yen Lin, Akira Taguchi, Satoshi Mori, Julie Li-Yu, Seng Bin Ang, Ding-Cheng Chan, Wai Sin Chan, Hou Ng, Jung-Fu Chen, Shih-Te Tu, Hai-Hua Chuang, Yin-Fan Chang, Fang-Ping Chen, Keh-Sung Tsai, Peter R Ebeling, Fernando Marin, Francisco Javier Nistal RodrÃguez, Huipeng Shi, Kyu Ri Hwang, Kwang-Kyoun Kim, Yoon-Sok Chung, Ian R Reid, Manju Chandran, Serge Ferrari, E Michael Lewiecki, Fen Lee Hew, Lan T Ho-Pham, Tuan Van Nguyen, Van Hy Nguyen, Sarath Lekamwasam, Dipendra Pandey, Sanjay Bhadada, Chung-Hwan Chen, Jawl-Shan Hwang, Chih-Hsing Wu
OBJECTIVES: This study aimed to present the Asia-Pacific consensus on long-term and sequential therapy for osteoporosis, offering evidence-based recommendations for the effective management of this chronic condition. The primary focus is on achieving optimal fracture prevention through a comprehensive, individualized approach. METHODS: A panel of experts convened to develop consensus statements by synthesizing the current literature and leveraging clinical expertise...
March 2024: Osteoporosis and Sarcopenia
#9
JOURNAL ARTICLE
Ichiro Yoshii, Naoya Sawada, Tatsumi Chijiwa
OBJECTIVES: Bone fragility fracture (BFF) is a serious incident in treating rheumatoid arthritis (RA). We hypothesized that pain degree during treatment RA correlated with incident BFF and validated how pain affects incident BFF (inc-BFF). METHODS: Postmenopausal RA patients treated for at least 3 years were recruited. The primary endpoint was the development of inc-BFF. Follow-up began with the first bone mineral density measurement (baseline) and continued until the development of the first BFF or termination of the study...
December 2023: Osteoporosis and Sarcopenia
#10
JOURNAL ARTICLE
Kazuki Fujimoto, Narumi Maki, Daisuke Hashiba, Toshifumi Maeyama, Ryosuke Nakagawa, Hajime Arai, Seiji Ohtori
OBJECTIVES: This study aims to investigate the effects of romosozumab on bone mineral density (BMD) and bone metabolism. METHODS: In this retrospective case series, romosozumab was administered to 5 premenopausal female patients with osteoporosis and anorexia nervosa with fragility fractures. BMD and bone turnover marker changes were investigated at 6 months and 1 year after administering romosozumab. RESULTS: BMD increased and high-turnover bone metabolism decreased 6 months and 1 year after administering romosozumab...
December 2023: Osteoporosis and Sarcopenia
#11
JOURNAL ARTICLE
Lijy K Babu, Snigdha Shaw, Dishari Ghosh
OBJECTIVES: High altitude possesses a great challenge for human survival owing to low oxygen tension and has been reported to cause bone deterioration among sojourns of high altitude. The bone health of Ladakhi women is investigated for the first time in this study. METHODS: Dual energy X-ray absorptiometry of Ladakhi women and sea level women was done at the radius and calcaneus using EXA-3000 (Osteosys, Korea), followed by colorimetric and Enzyme Linked Immunosorbent Assay analysis of parameters regulating bone health...
December 2023: Osteoporosis and Sarcopenia
#12
REVIEW
Se-Min Kim, Funda Korkmaz, Steve Sims, Vitaly Ryu, Tony Yuen, Mone Zaidi
Hypophosphatasia (HPP), also called Rathbun disease, is a rare genetic disorder that is caused by the loss-of-function mutation in the ALPL gene encoding tissue non-specific alkaline phosphatase. Doctor Rathbun first described the case of a 3-week-old infant who presented with severe osteopenia, rickets, and multiple radiographic fractures, and died shortly after of epileptic seizure and respiratory distress. The term "hypophosphatasia" was coined as the patients' alkaline phosphatase levels were significantly low...
December 2023: Osteoporosis and Sarcopenia
#13
JOURNAL ARTICLE
Amir Mohammad Vahdani, Mahnaz Sanjari, Noushin Fahimfar, Mahbube Ebrahimpur, Gita Shafiee, Kazem Khalagi, Mohammad Javad Mansourzadeh, Iraj Nabipour, Bagher Larijani, Afshin Ostovar
OBJECTIVES: This cross-sectional study, conducted as part of the Bushehr Elderly Health program stage II in Bushehr, Iran, aimed to evaluate health-related quality of life (HR-QoL) in individuals aged ≥ 60 with osteosarcopenia, a condition characterized by the co-occurrence of osteopenia/osteoporosis and sarcopenia. Given the increasing elderly population worldwide, understanding the HR-QoL of this demographic is crucial, with osteosarcopenia being a significant factor. METHODS: The study enrolled 2369 participants aged ≥ 60 and collected demographic and anthropometric data...
December 2023: Osteoporosis and Sarcopenia
#14
JOURNAL ARTICLE
Shun Igarashi, Yuji Kasukawa, Koji Nozaka, Hiroyuki Tsuchie, Kazunobu Abe, Hikaru Saito, Ryo Shoji, Fumihito Kasama, Shuntaro Harata, Kento Okamoto, Keita Oya, Naohisa Miyakoshi
OBJECTIVES: Chronic kidney disease (CKD) complicated by secondary hyperparathyroidism (SHPT) is associated with an increased risk of fragility fractures. Etelcalcetide (EC) is a treatment for SHPT that reduces serum parathyroid hormone (PTH) levels. However, the effects of combined treatment with osteoporosis drugs such as teriparatide (TPTD) remain unclear. This study investigates the combined effects of EC and TPTD on bone in CKD model rats. METHODS: The CKD model was established in 8-week-old male Wistar rats by feeding them a 0...
December 2023: Osteoporosis and Sarcopenia
#15
JOURNAL ARTICLE
Jiyong Yang, Tao Jiang, Guangming Xu, Shuai Wang, Wengang Liu
OBJECTIVES: Accumulating evidence indicates a strong link between knee osteoarthritis (KOA) and sarcopenia. However, the mechanisms involved have not yet been elucidated. This study primarily aims to explore the molecular mechanisms that explain the connection between these 2 disorders. METHODS: The gene expression profiles for KOA and sarcopenia were obtained from the Gene Expression Omnibus database, specifically from GSE55235, GSE169077, and GSE1408. Various bioinformatics techniques were employed to identify and analyze common differentially expressed genes (DEGs) across the 3 datasets...
September 2023: Osteoporosis and Sarcopenia
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JOURNAL ARTICLE
Jia Wen Chong, Tik S Chan, Joseph C Lee
No abstract text is available yet for this article.
September 2023: Osteoporosis and Sarcopenia
#17
JOURNAL ARTICLE
Ching-Lung Cheung
No abstract text is available yet for this article.
September 2023: Osteoporosis and Sarcopenia
#18
JOURNAL ARTICLE
Dinh Tan Nguyen, Thao P Ho-Le, Liem Pham, Vinh P Ho-Van, Tien Dat Hoang, Thach S Tran, Steve Frost, Tuan V Nguyen
OBJECTIVES: Osteoporotic fracture is a significant public health burden associated with increased mortality risk and substantial healthcare costs. Accurate and early identification of high-risk individuals and mitigation of their risks is a core part of the treatment and prevention of fractures. Here we introduce a digital tool called 'BONEcheck' for personalized assessment of bone health. METHODS: The development of BONEcheck primarily utilized data from the prospective population-based Dubbo Osteoporosis Epidemiology Study and the Danish Nationwide Registry...
September 2023: Osteoporosis and Sarcopenia
#19
JOURNAL ARTICLE
Saori Miyazaki, Koutatsu Maruyama, Kiyohide Tomooka, Shinji Nishioka, Noriko Miyoshi, Ryoichi Kawamura, Yasunori Takata, Haruhiko Osawa, Takeshi Tanigawa, Isao Saito
OBJECTIVES: Few studies examined the association between deterioration of masticatory ability assessed by objective marker and physical function. Therefore, we examined the association between salivary flow rate which is one of the objective and surrogate marker of masticatory ability and lower Timed Up & Go (TUG) performance which is one of major measurement of physical function among aging Japanese. METHODS: This cross-sectional study enrolled 464 Japanese aged 60-84 years old...
September 2023: Osteoporosis and Sarcopenia
#20
JOURNAL ARTICLE
Suhas Krishnamoorthy, Gloria Hoi-Yee Li, Kelvin Shun-Cheong Ho, Yin-Pan Chau, Constance Mak, Donna Ng, Albert Kar-Kin Chung, Jody Kwok-Pui Chu, Kathryn Choon-Beng Tan, Ruby Lai-Chong Hoo, Ching-Lung Cheung
OBJECTIVES: To evaluate the association of illicit drug use with bone mineral density (BMD) and hip geometric parameters at the narrow neck. METHODS: This is a cross-sectional matched cohort study conducted in the Hong Kong Chinese population. Associations with illicit drug use were estimated using linear regression for BMD (lumbar spine and femoral neck) and hip geometrical parameters (cross-sectional area [CSA], cross-sectional moment of inertia [CSMI], section modulus [SM], average cortical thickness [ACT] and BMD at the narrow neck) after adjusting for age, body mass index (BMI), smoking status, drinking status, physical activity, and history of antipsychotic and antidepressant use...
September 2023: Osteoporosis and Sarcopenia
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