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Asthma Research and Practice

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https://www.readbyqxmd.com/read/30094051/exhaled-biomarkers-in-childhood-asthma-old-and-new-approaches
#1
REVIEW
Valentina Ferraro, Silvia Carraro, Sara Bozzetto, Stefania Zanconato, Eugenio Baraldi
Background: Asthma is a chronic condition usually characterized by underlying inflammation. The study of asthmatic inflammation is of the utmost importance for both diagnostic and monitoring purposes. The gold standard for investigating airway inflammation is bronchoscopy, with bronchoalveolar lavage and bronchial biopsy, but the invasiveness of such procedures limits their use in children. For this reason, in the last decades there has been a growing interest for the development of noninvasive methods...
2018: Asthma Research and Practice
https://www.readbyqxmd.com/read/30026958/assessment-of-predictors-for-acute-asthma-attack-in-asthmatic-patients-visiting-an-ethiopian-hospital-are-the-potential-factors-still-a-threat
#2
Sewunet Admasu Belachew, Daniel Asfaw Erku, Dawit Kumilachew Yimenu, Begashaw Melaku Gebresillassie
Background: Recurrent exacerbations in patients with moderate or severe asthma are the major causes of morbidity, mortality and medical expenditure. Identifying predictors of frequent asthma attack might offer the fertile ground of asthma management. However, systematic data on asthma management is scarce in Ethiopia. Objective: The purpose of the present study was to determine predictors of acute asthma attack in patients with asthma attending emergency department of University of Gondar Comprehensive Specialized Hospital (UOGCSH) in Gondar, northwestern Ethiopia...
2018: Asthma Research and Practice
https://www.readbyqxmd.com/read/29796287/effect-of-adjusting-the-combination-of-budesonide-formoterol-on-the-alleviation-of-asthma-symptoms
#3
Ryosuke Souma, Kumiya Sugiyama, Hiroyuki Masuda, Hajime Arifuku, Kentaro Nakano, Hiroyoshi Watanabe, Tomoshige Wakayama, Shingo Tokita, Masamitsu Tatewaki, Hideyuki Satoh, Kenya Koyama, Yumeko Hayashi, Fumiya Fukushima, Hirokuni Hirata, Masafumi Arima, Kazuhiro Kurasawa, Takeshi Fukuda, Yasutsugu Fukushima
Background: The combination of budesonide + formoterol (BFC) offers the advantages of dose adjustment in a single inhaler according to asthma symptoms. We analyzed the relationship between asthma symptoms in terms of peak expiratory flow (PEF) and dose adjustment by the patient. Methods: Twenty-eight patients with asthma who used BFC for alleviation of their symptoms (12 men, 16 women; 60 years old) were instructed that the inhaled BFC dose could be increased to a maximum of 8 inhalations per day according to symptom severity...
2018: Asthma Research and Practice
https://www.readbyqxmd.com/read/29736253/associations-of-physical-activity-with-childhood-asthma-a-population-study-based-on-the-who-health-behaviour-in-school-aged-children-survey
#4
Lene Lochte, Poul Erik Petersen, Kim G Nielsen, Anette Andersen, Thomas A E Platts-Mills
Background: Asthma in paediatric populations is one of the highest public health concerns. In this study of children and adolescents, we hypothesized that low levels of physical activity (PA) would show associations with asthma that vary by asthma outcome. The objective was to assess whether PA was associated with ever asthma and/or current asthma . Methods: Analyses were based on 4824 Danish schoolchildren aged 11-15 years old (48.7% boys) participating in the HBSC survey...
2018: Asthma Research and Practice
https://www.readbyqxmd.com/read/29713490/clinical-characteristics-and-comorbidities-of-elderly-asthmatics-who-attend-allergy-clinics
#5
Anahí Yáñez, Marcela Soria, Susana De Barayazarra, Nancy Recuero, Francisco Rovira, Edgardo Jares, Ana María Stok, Sergio Nemirovsky, Carlos Bueno
Background: To date, few studies have focused on the clinical and allergic characteristics of asthma in the elderly, defined as asthma in people aged 60 or over. Thus, we propose to identify and study the clinical and allergic characteristics and comorbidities of patients with asthma among the elderly. Methods: A retrospective, observational, descriptive study was developed in five clinics and hospitals in Argentina. Allergy Physicians analyzed their patients' medical records in 2014 and included those adults over the age of 60, who had been diagnosed with asthma according to the GINA guidelines...
2018: Asthma Research and Practice
https://www.readbyqxmd.com/read/29588858/single-nucleotide-polymorphisms-in-asthma-candidate-genes-tbxa2r-adam33-fcer1b-and-ormdl3-in-pakistani-asthmatics-a-case-control-study
#6
Nusrat Saba, Osman Yusuf, Sadia Rehman, Saeeda Munir, Amna Noor, Muhammad Saqlain, Atika Mansoor, Ghazala Kaukab Raja
Background: Genetic variations in different loci and genes are important in asthma pathogenesis. There is much importance of various immunological pathways in the IgE secretion regulation. Alterations in any main part of these pathways can increase the risk of asthma development. Polymorphisms in these genetic markers can effect certain pathways which predict the asthma susceptibility. In the present study, SNPs directly or indirectly affecting the immunological process pathways are selected...
2018: Asthma Research and Practice
https://www.readbyqxmd.com/read/29568538/inhalation-of-hydrogen-gas-attenuates-airway-inflammation-and-oxidative-stress-in-allergic-asthmatic-mice
#7
Ning Zhang, Changwen Deng, Xingxing Zhang, Jingxi Zhang, Chong Bai
Background: Asthma is a worldwide common chronic airway disease that cannot be cured and results in the huge burden in public health. Oxidative stress was considered an important mechanism in the pathogenesis of asthma. Hydrogen gas been demonstrated to function as a novel antioxidant and exert therapeutic antioxidant activity in a number of diseases and the function of this nontoxic gas in asthma was unclear. The purpose of the study aims to examine the effect of inhalation hydrogen gas on the pathophysiology of a mouse model of asthma...
2018: Asthma Research and Practice
https://www.readbyqxmd.com/read/29387439/assessment-of-knowledge-and-education-relating-to-asthma-during-pregnancy-among-women-of-childbearing-age
#8
Mohammed O Al Ghobain, Mohammed AlNemer, Mohammad Khan
Background: Misconceptions about medications' safety can lead pregnant women with asthma to stop their medications, resulting in asthma-related neonatal morbidity and mortality. Our aim was to assess the level of pregnancy-related asthma knowledge and education about asthma medications' safety, among women of childbearing age with a history of bronchial asthma. Methods: A cross-sectional survey of convenience sample of outpatient clinic attendees of Pulmonary, Family Medicine and Obstetrics & Gynecology among women of childbearing age with history of asthma at King Abdulaziz Medical City, Riyadh, Saudi Arabia...
2018: Asthma Research and Practice
https://www.readbyqxmd.com/read/29318023/microbiome-and-asthma
#9
REVIEW
Milena Sokolowska, Remo Frei, Nonhlanhla Lunjani, Cezmi A Akdis, Liam O'Mahony
The mucosal immune system is in constant communication with the vast diversity of microbes present on body surfaces. The discovery of novel molecular mechanisms, which mediate host-microbe communication, have highlighted the important roles played by microbes in influencing mucosal immune responses. Dendritic cells, epithelial cells, ILCs, T regulatory cells, effector lymphocytes, NKT cells and B cells can all be influenced by the microbiome. Many of the mechanisms being described are bacterial strain- or metabolite-specific...
2018: Asthma research and practice
https://www.readbyqxmd.com/read/29201385/identifying-the-hidden-burden-of-allergic-rhinitis-ar-in-community-pharmacy-a-global-phenomenon
#10
Rachel Tan, Biljana Cvetkovski, Vicky Kritikos, David Price, Kwok Yan, Pete Smith, Sinthia Bosnic-Anticevich
Background: Patients with allergic rhinitis often trivialise their condition, self-manage inappropriately, and would benefit from health care intervention. The primary point of health care contact for these self-managing allergic rhinitis patients is the community pharmacy. With the majority of allergic rhinitis treatments being available for purchase over the counter, without health care professional contact, we know little about how the patients self-manage. This study aims to identify the burden of allergic rhinitis in the community pharmacy and to identify key opportunity for intervention...
2017: Asthma Research and Practice
https://www.readbyqxmd.com/read/29046815/non-adherence-to-inhalational-medications-and-associated-factors-among-patients-with-asthma-in-a-referral-hospital-in-ethiopia-using-validated-tool-tai
#11
Asnakew Achaw Ayele, Henok Getachew Tegegn
BACKGROUND: Asthma is a chronic inflammatory condition of the airways that affects roughly 358 million people globally. It is a serious global health problem with an increasing prevalence worldwide. Most people affected are in low- and middle-income countries including Ethiopia. The association between non -adherence and poor disease control is clearly stated in different literatures. The main objective of the present study was to assess self-reported non- adherence level and to identify the potential factors associated with non-adherence...
2017: Asthma Research and Practice
https://www.readbyqxmd.com/read/28794889/ambient-ozone-and-asthma-hospital-admissions-in-texas-a-time-series-analysis
#12
Julie E Goodman, Ke Zu, Christine T Loftus, Ge Tao, Xiaobin Liu, Sabine Lange
BACKGROUND: Many studies have evaluated associations between asthma emergency department (ED) visits, hospital admissions (HAs), and ambient ozone (O3) across the US, but not in Texas. We investigated the relationship between O3 and asthma HAs, and the potential impacts of outdoor pollen, respiratory infection HAs, and the start of the school year in Texas. METHODS: We obtained daily time-series data on asthma HAs and ambient O3 concentrations for Dallas, Houston, and Austin, Texas for the years 2003-2011...
2017: Asthma Research and Practice
https://www.readbyqxmd.com/read/28588900/associations-between-serum-25-oh-d-concentrations-and-prevalent-asthma-among-children-living-in-communities-with-differing-levels-of-urbanization-a-cross-sectional-study
#13
Suzanne L Pollard, John J Lima, Karina Romero, Carla Tarazona-Meza, Edward Mougey, Katherine Tomaino, Gary Malpartida-Guzmán, Nadia N Hansel, William Checkley
BACKGROUND: Prior evidence suggests that vitamin D deficiency may increase the risk of asthma and atopy and impair pulmonary function in children. METHODS: In this cross-sectional analysis nested in a case-control study, we analyzed serum 25(OH)D concentrations in 413 children with asthma and 471 children without asthma living in two geographically adjacent study communities (Pampas and Villa El Salvador). We measured total and antigen-specific IgE levels, pulmonary function, asthma control, and exhaled nitric oxide...
2017: Asthma Research and Practice
https://www.readbyqxmd.com/read/28507765/asthma-epidemiology-of-disease-control-in-latin-america-short-review
#14
REVIEW
Dirceu Solé, Carolina Sanchez Aranda, Gustavo Falbo Wandalsen
Asthma is reported as one of the most common chronic diseases in childhood, impairing the quality of life of patients and their families and incurring high costs to the healthcare system and society. Despite the development of new drugs and the availability of international treatment guidelines, asthma is still poorly controlled, especially in Latin America. Original and review articles on asthma control or epidemiology with high levels of evidence have been selected for analysis among those published in PubMed referenced journals during the last 20 years, using the following keywords: "asthma control" combined with "Latin America", " epidemiology", "prevalence", "burden", "mortality", "treatment and unmet needs", "children", "adolescents", and "infants"...
2017: Asthma Research and Practice
https://www.readbyqxmd.com/read/28428890/asthma-in-the-elderly-a-double-blind-placebo-controlled-study-of-the-effect-of-montelukast
#15
Michele Columbo
BACKGROUND: Little is known about asthma in the elderly as most studies of this condition have not included this patient group. It is unclear whether leukotriene antagonists benefit older asthmatics. We studied the effect of adding montelukast to the asthma treatment of elderly subjects. METHODS: Twenty-five subjects 65 years old and older with asthma were evaluated at week 0, 1, 5, 9, 13, and 17. Each subject received montelukast 10 mg and placebo each for 8 weeks in a cross-over design...
2017: Asthma Research and Practice
https://www.readbyqxmd.com/read/28138394/gender-specific-determinants-of-asthma-among-u-s-adults
#16
Rebecca Greenblatt, Omar Mansour, Edward Zhao, Michelle Ross, Blanca E Himes
BACKGROUND: Asthma, a chronic respiratory disease affecting over 18.7 million American adults, has marked disparities by gender, race/ethnicity and socioeconomic status. Our goal was to identify gender-specific demographic and socioeconomic determinants of asthma prevalence among U.S. adults using data from the Behavioral Risk Factors Surveillance System (BRFSS) and the National Health and Nutrition Examination Survey (NHANES). METHODS: Gender-specific regression analyses were performed to model the relationship between asthma prevalence with age, race/ethnicity, income, education level, smoking status, and body mass index (BMI), while taking into account the study designs...
2017: Asthma Research and Practice
https://www.readbyqxmd.com/read/28078100/asthma-costs-and-social-impact
#17
REVIEW
Carlos Nunes, Ana Margarida Pereira, Mário Morais-Almeida
In recent decades, both asthma prevalence and incidence have been increasing worldwide, not only due to the genetic background, but mainly because of the effect of a wide number of environmental and lifestyle risk factors. In many countries noncommunicable diseases, like asthma, are not yet considered a healthcare priority. This review will analyze and discuss disparities in asthma management in several countries and regions, such as access to healthcare human resources and medications, due to limited financial capacity to develop strategies to control and prevent this chronic disease...
2017: Asthma Research and Practice
https://www.readbyqxmd.com/read/27965781/preacutionary-labelling-of-cross-reactive-foods-the-case-of-rapeseed
#18
REVIEW
Alessandro Fiocchi, Lamia Dahdah, Carla Riccardi, Oscar Mazzina, Vincenzo Fierro
Food allergic individuals are exposed to unnecessary dietary restrictions due to precautionary food allergy labelling (PFAL). Two forms of PFAL exist: type I identifies the possible presence of allergenic contaminaion in foods ('may content…'), type II indicates as potentially dangerous ingredients or contaminants that do no belong to official list of food allergens. PFAL type II is based on the fear of cross-reactivity with foods belonging to that list. PFAL type II is less known, but may be tempting for the legal offices of food companies, for clinicians in a 'defensive medicine' key, and even for legislators...
2016: Asthma Research and Practice
https://www.readbyqxmd.com/read/27965780/manifesto-on-small-airway-involvement-and-management-in-asthma-and-chronic-obstructive-pulmonary-disease-an-interasma-global-asthma-association-gaa-and-world-allergy-organization-wao-document-endorsed-by-allergic-rhinitis-and-its-impact-on-asthma-aria-and-global
#19
F Braido, N Scichilone, F Lavorini, O S Usmani, L Dubuske, L P Boulet, R Mosges, C Nunes, M Sánchez-Borges, I J Ansotegui, M Ebisawa, F Levi-Schaffer, L J Rosenwasser, J Bousquet, T Zuberbier, G Walter Canonica
Evidence that enables us to identify, assess, and access the small airways in asthma and chronic obstructive pulmonary disease (COPD) has led INTERASMA (Global Asthma Association) and WAO to take a position on the role of the small airways in these diseases. Starting from an extensive literature review, both organizations developed, discussed, and approved the manifesto, which was subsequently approved and endorsed by the chairs of ARIA and GA2 LEN. The manifesto describes the evidence gathered to date and defines and proposes issues on small airway involvement and management in asthma and COPD with the aim of challenging assumptions, fostering commitment, and bringing about change...
2016: Asthma research and practice
https://www.readbyqxmd.com/read/27965779/asthma-phenotypes-the-intriguing-selective-intervention-with-montelukast
#20
REVIEW
Cottini Marcello, Lombardi Carlo
Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation and a variable course associated with various underlying mechanisms that can differ between individuals. Patients with asthma can therefore exhibit different phenotypes, a term used to define the observable characteristics of an organism resulting from the interaction between its genetic makeup and the environment. The heterogeneity of asthma has received a large amount of attention in the last few years in order to better tailor treatment according to the different clinical and biological phenotypes of the disease...
2016: Asthma Research and Practice
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