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RANDOMIZED CONTROLLED TRIAL
Kamilla Truong, Kaare Meier, Lasse Cramer Ahrens, Thea Overgaard Wichmann, Hamed Zaer, Lasse Hubertus Tiroke, Simon Arvin, Mindaugas Bazys, Peter Duel, Gudrun Gudmundsdottir, Jakob Gram Carlsen, Lone Nikolajsen, Maurits van Tulder, Jens Christian Hedemann Sørensen, Mikkel Mylius Rasmussen
OBJECTIVE: A comparison of cryoneurolysis or radio frequency (RF) with placebo in patients with facetogenic chronic low back pain (LBP) for patient global impression of change (PGIC), pain intensity, function and quality of life, with 1-year follow-up. DESIGN: Single-centre, single-blinded placebo-controlled randomised controlled trial. SETTING: Single-centre study. PARTICIPANTS: Inclusion from March 2020 to September 2022: consenting adults over 18 years of age, LBP>3 months, average Numeric Rating Scale LBP≥4 average last 14 days and a positive response to a diagnostic medial branch block (<u>></u>50% pain reduction after 60 min)...
May 9, 2024: RMD Open
#2
JOURNAL ARTICLE
Martin Fruth, Lucie Künitz, Philipp Martin-Seidel, Styliani Tsiami, Xenofon Baraliakos
BACKGROUND: Non-synovial inflammation as detected by MRI is characteristic in polymyalgia rheumatica (PMR) with potentially high diagnostic value. OBJECTIVE: The objective is to describe inflammatory MRI findings in the shoulder girdle of patients with PMR and discriminate from other causes of shoulder girdle pain. METHODS: Retrospective study of 496 contrast-enhanced MRI scans of the shoulder girdle from 122 PMR patients and 374 non-PMR cases...
May 9, 2024: RMD Open
#3
RANDOMIZED CONTROLLED TRIAL
Martin Rudwaleit, Atul Deodhar, Lars Bauer, Lianne Gensler, Bengt Hoepken, Thomas Kumke, Simone Emanuele Auteri, Mindy Kim, Walter Maksymowych
OBJECTIVE: There is a paucity of data on long-term clinical responses in patients with non-radiographic axial spondyloarthritis (nr-axSpA) based on their baseline objective signs of inflammation such as MRI or C-reactive protein (CRP) levels. This study reports clinical outcomes up to 3 years of the C-axSpAnd trial, including safety follow-up extension (SFE) from Weeks 52 to 156, stratified by patients' baseline MRI and CRP status. METHODS: C-axSpAnd (NCT02552212) was a phase 3, multicentre study that evaluated certolizumab pegol (CZP) in patients with active nr-axSpA who had active sacroiliitis on MRI and/or elevated CRP...
May 9, 2024: RMD Open
#4
EDITORIAL
Chi Chiu Mok
No abstract text is available yet for this article.
May 3, 2024: RMD Open
#5
RANDOMIZED CONTROLLED TRIAL
Joy Ardjuna van der Pol, Cornelia F Allaart, Willem Lems, Sjoerd M van der Kooij, Tom W J Huizinga, Sytske Anne Bergstra
OBJECTIVES: To assess whether prednisone use and/or disease activity score (DAS) are associated with the development of hyperglycaemia and diabetes in rheumatoid arthritis (RA). METHODS: We included 504 non-diabetic early RA patients from the BeSt study (Dutch acronym for treatment strategies). Patients were randomised to four DAS-steered treatment arms and followed for 10 years. The associations between DAS and prednisone use with glucose levels and the occurrence of hyperglycaemia over time were assessed with linear and logistic mixed effects regression models...
April 30, 2024: RMD Open
#6
JOURNAL ARTICLE
Anna Wilding, Rona Smith, David Jayne, Mårten Segelmark, Aladdin J Mohammad
OBJECTIVES: To describe clinical and laboratory characteristics and outcomes in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and thyroid disease (TD). We also aimed to calculate incidence and identify predictors of TD in two large cohorts of patients with AAV. METHODS: The study comprised 644 patients with AAV in a population-based cohort from southern Sweden (n=325) and a cohort from a specialised vasculitis centre in Cambridge, UK (n=319)...
April 30, 2024: RMD Open
#7
MULTICENTER STUDY
Jennifer Scott, Arthur White, Cathal Walsh, Louis Aslett, Matthew A Rutherford, James Ng, Conor Judge, Kuruvilla Sebastian, Sorcha O'Brien, John Kelleher, Julie Power, Niall Conlon, Sarah M Moran, Raashid Ahmed Luqmani, Peter A Merkel, Vladimir Tesar, Zdenka Hruskova, Mark A Little
OBJECTIVE: ANCA-associated vasculitis (AAV) is a relapsing-remitting disease, resulting in incremental tissue injury. The gold-standard relapse definition (Birmingham Vasculitis Activity Score, BVAS>0) is often missing or inaccurate in registry settings, leading to errors in ascertainment of this key outcome. We sought to create a computable phenotype (CP) to automate retrospective identification of relapse using real-world data in the research setting. METHODS: We studied 536 patients with AAV and >6 months follow-up recruited to the Rare Kidney Disease registry (a national longitudinal, multicentre cohort study)...
April 30, 2024: RMD Open
#8
JOURNAL ARTICLE
Dale E Fournier, Michele C Battie, Cheryle A Séguin
OBJECTIVES: The purpose of our study was to characterise spatiotemporal features of disease progression in people with diffuse idiopathic skeletal hyperostosis (DISH), early-phase DISH, and those not meeting either criterion who had repeated CT scans of the thoracic spine. METHODS: A retrospective study was designed in collaboration with the Rochester Epidemiology Project to evaluate completeness of ectopic bridging across the thoracic spine and corresponding disease status over an average of 2...
April 27, 2024: RMD Open
#9
JOURNAL ARTICLE
Chiara Tani, Francesca Trentin, Alice Parma, Dina Zucchi, Chiara Cardelli, Chiara Stagnaro, Elena Elefante, Viola Signorini, Linda Carli, Maria Laura Manca, Marta Mosca
OBJECTIVES: Undifferentiated connective tissue diseases (UCTDs) are systemic autoimmune conditions that cannot be diagnosed nor classified as defined CTD; the majority maintains an undifferentiated profile (stable UCTD, sUCTD) over time. Data on long-term outcomes of sUCTD are lacking. METHODS: Retrospective longitudinal analysis of an inception cohort of 141 patients with sUCTD.Disease evolution and damage accrual were evaluated at 1, 5 and 10 years. Partial least square (PLS) regression was used to identify the basal variables contributing to damage accrual at 1, 5 and 10 years of follow-up...
April 25, 2024: RMD Open
#10
MULTICENTER STUDY
Laura Andreoli, Maria Chiara Gerardi, Maria Gerosa, Davide Rozza, Francesca Crisafulli, Roberta Erra, Daniele Lini, Laura Trespidi, Melissa Padovan, Francesca Ruffilli, Francesca Serale, Giovanna Cuomo, Bernd Raffeiner, Paolo Semeraro, Chiara Tani, Maria Sole Chimenti, Paola Conigliaro, Ariela Hoxha, Cecilia Nalli, Micaela Fredi, Maria Grazia Lazzaroni, Matteo Filippini, Marco Taglietti, Franco Franceschini, Sonia Zatti, Chiara Loardi, Rossana Orabona, Francesca Ramazzotto, Cristina Zanardini, Giulia Fontana, Giorgia Gozzoli, Claudia Barison, Paola Bizioli, Roberto Felice Caporali, Giulia Carrea, Manuela Wally Ossola, Beatrice Maranini, Ettore Silvagni, Marcello Govoni, Danila Morano, Rosita Verteramo, Andrea Doria, Teresa Del Ross, Maria Favaro, Antonia Calligaro, Marta Tonello, Maddalena Larosa, Margherita Zen, Alessandra Zambon, Marta Mosca, Dina Zucchi, Elena Elefante, Sabrina Gori, Florenzo Iannone, Maria Grazia Anelli, Marlea Lavista, Anna Abbruzzese, Carlo Giuseppe Fasano, Salvatore D'Angelo, Maria Stefania Cutro, Valentina Picerno, Teresa Carbone, Angela Anna Padula, Patrizia Rovere-Querini, Valentina Canti, Rebecca De Lorenzo, Ludovica Cavallo, Véronique Ramoni, Carlomaurizio Montecucco, Veronica Codullo, Alessandra Milanesi, Giulia Pazzola, Giuseppina Comitini, Chiara Marvisi, Carlo Salvarani, Oscar Massimiliano Epis, Sara Benedetti, Giuseppina Di Raimondo, Clizia Gagliardi, Claudia Lomater, Gloria Crepaldi, Elisa Bellis, Francesca Bellisai, Estrella Garcia Gonzalez, Anna Paola Pata, Martina Zerbinati, Maria Letizia Urban, Irene Mattioli, Annamaria Iuliano, Giandomenico Sebastiani, Antonio Luca Brucato, Emanuele Bizzi, Maurizio Cutolo, Leonardo Santo, Sara Tonetta, Gianpiero Landolfi, Greta Carrara, Alessandra Bortoluzzi, Carlo Alberto Scirè, Angela Tincani
OBJECTIVES: To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) in the Italian prospective cohort study P-RHEUM.it. METHODS: Pregnant women with different ARD were enrolled for up to 20 gestational weeks in 29 Rheumatology Centres for 5 years (2018-2023). Maternal and infant information were collected in a web-based database. RESULTS: We analysed 866 pregnancies in 851 patients (systemic lupus erythematosus was the most represented disease, 19...
April 24, 2024: RMD Open
#11
JOURNAL ARTICLE
Nils Bürgisser, Denis Mongin, Samia Mehouachi, Clement P Buclin, Romain Guemara, Pauline Darbellay Farhoumand, Olivia Braillard, Kim Lauper, Delphine S Courvoisier
OBJECTIVE: To develop an automatic gout register from electronic health records (EHRs) data. METHODS: We analysed the EHR of all patients >18 years old from a tertiary academic hospital (2013-2022) based on six criteria: International Classification of Diseases 10 gout diagnosis, urate-lowering therapy prescription, monosodium urate crystals in joint aspiration and gout-related terms in problem lists, clinical or imaging reports. We assessed the positive and negative predictive value (PPV and NPV) of the query by chart reviews...
April 24, 2024: RMD Open
#12
JOURNAL ARTICLE
Xianhua Gui, Wangzhong Li, Hanyi Jiang, Rujia Wang, Min Yu, Tingting Zhao, Miao Ma, Jingjing Ding, Ziyi Jin, Yuying Qiu, Xiaohua Qiu, Yingwei Zhang, Min Cao, Mei Huang, Mengshu Cao, Jinghong Dai, Hourong Cai, Xiaoyan Xin, Yonglong Xiao
OBJECTIVES: Risk prediction for patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD) is challenging due to heterogeneity in the disease course. We aimed to develop a mortality risk prediction model for PM/DM-ILD. METHODS: This prognostic study analysed patients with PM/DM-ILD admitted to Nanjing Drum Hospital from 2016 to 2021. The primary outcome was mortality within 1 year. We used a least absolute shrinkage and selection operator (LASSO) logistic regression model to identify predictive laboratory indicators...
April 24, 2024: RMD Open
#13
JOURNAL ARTICLE
Nadine Zehrfeld, Malin Abelmann, Sabrina Benz, Clara Luisa Zippel, Sonja Beider, Emelie Kramer, Tabea Seeliger, Georgios Sogkas, Vega Gödecke, Gerrit Ahrenstorf, Franz Paul Armbruster, Thomas Skripuletz, Torsten Witte, Anselm Arthur Derda, Kristina Sonnenschein, Diana Ernst
OBJECTIVES: Cardiovascular comorbidities are common in patients with autoimmune diseases. This study investigates the extent of subclinical atherosclerosis in patients with primary Sjögren's syndrome (pSS). Correlations with clinical factors such as organ involvement (OI) or disease activity were analysed and oxLDL antibodies (oxLDL ab) were measured as potential biomarkers of vascular damage. METHODS: Patients with pSS were consecutively included from the rheumatology outpatient clinic...
April 24, 2024: RMD Open
#14
JOURNAL ARTICLE
Claus Rasmussen, Jesper Walther Larsen, Heidi Mächler Christensen, Monica Bak Larsen, Anna Marie Thomsen, Tinna Leishmann, Jette Kragh, Gunnar Lauge Nielsen
OBJECTIVES: Currently, gout management, particularly urate-lowering therapy (ULT), is often suboptimal. Nurses successfully manage various diseases including gout. As gout prevalence is rising, and rheumatologists and general practitioners face shortages, a new approach is imperative. This real-life prospective cohort study evaluated the effectiveness of nurse-led care employing a treat-to-target strategy for gout management over a 2-year period. METHODS: All consecutively confirmed gout patients were included...
April 24, 2024: RMD Open
#15
JOURNAL ARTICLE
Yaëlle R Besten, Laura Boekel, Maurice Steenhuis, Femke Hooijberg, Sadaf Atiqi, Maureen Leeuw, Erik H Vogelzang, Jim Keijser, Sofie Keijzer, Floris C Loeff, Martijn Gerritsen, Sander W Tas, Michael T Nurmohamed, Theo Rispens, Gertjan Wolbink
BACKGROUND: During the COVID-19 pandemic, we developed a digital research platform to longitudinally investigate COVID-19-related outcomes in patients with rheumatic diseases and healthy controls. We used home finger-prick testing in order to collect serum samples remotely and increase the overall efficiency of the platform. The aim of the present study was to evaluate the success rate of the finger prick and patients' perspective towards the finger prick. METHODS: Serum samples were collected up to five times during follow-up, either via a venepuncture at the research institute or a finger prick from participants' home...
April 19, 2024: RMD Open
#16
JOURNAL ARTICLE
Guenter Steiner, Patrick Verschueren, Lieve Van Hoovels, Paul Studenic, Xavier Bossuyt
Classification criteria have been developed for rheumatoid arthritis (RA) and other rheumatic diseases in order to gather a homogeneous patient population for clinical studies and facilitate the timely implementation of therapeutic measures. Although classification criteria are not intended to be used for diagnosis, they are frequently used to support the diagnostic process in clinical practice, including clinical decision-making. The 2010 American College of Rheumatology (ACR)/European Alliance of Associations for Rheumatology (EULAR) classification criteria for RA are capable of identifying the majority of symptomatic patients with RA already in the earliest stages of the disease who are not yet showing radiographic changes...
April 19, 2024: RMD Open
#17
JOURNAL ARTICLE
Yen-Ju Chen, Tzu-Hung Hsiao, Ying-Cheng Lin, Wen-Juei Jeng, Chien-Lin Mao, Chia-Yi Wei, Yi-Chung Hsieh, Chih-Jen Huang, Mei-Hung Pan, I-Chieh Chen, Ching-Heng Lin, Yi-Ming Chen, Hwai-I Yang
OBJECTIVES: This study aimed to develop a predictive model using polygenic risk score (PRS) to forecast renal outcomes for adult systemic lupus erythematosus (SLE) in a Taiwanese population. METHODS: Patients with SLE (n=2782) and matched non-SLE controls (n=11 128) were genotyped using Genome-Wide TWB 2.0 single-nucleotide polymorphism (SNP) array. PRS models (C+T, LDpred2, Lassosum, PRSice-2, PRS-continuous shrinkage (CS)) were constructed for predicting SLE susceptibility...
April 18, 2024: RMD Open
#18
JOURNAL ARTICLE
Jessica Polo Y La Borda, Santos Castañeda, Elena Heras-Recuero, Fernando Sánchez-Alonso, Zulema Plaza, Carmen García Gómez, Ivan Ferraz-Amaro, Jesús Tomás Sanchez-Costa, Olga Carmen Sánchez-González, Ana Isabel Turrión-Nieves, Ana Perez-Alcalá, Carolina Pérez-García, Carlos González-Juanatey, Javier Llorca, Miguel Angel Gonzalez-Gay
OBJECTIVE: To assess the predictive value of four cardiovascular (CV) risk algorithms for identifying high-risk psoriatic arthritis (PsA) patients. METHODS: Evaluation of patients with PsA enrolled in the Spanish prospective project CARdiovascular in RheuMAtology. Baseline data of 669 PsA patients with no history of CV events at the baseline visit, who were followed in rheumatology outpatient clinics at tertiary centres for 7.5 years, were retrospectively analysed to test the performance of the Systematic Coronary Risk Assessment (SCORE), the modified version (mSCORE) European Alliance of Rheumatology Associations (EULAR) 2015/2016, the SCORE2 algorithm (the updated and improved version of SCORE) and the QRESEARCH risk estimator version 3 (QRISK3)...
April 17, 2024: RMD Open
#19
LETTER
Helena Codes-Méndez, Luis Sainz, Hye Sang Park, Hèctor Corominas, Cesar Diaz-Torne
No abstract text is available yet for this article.
April 15, 2024: RMD Open
#20
RANDOMIZED CONTROLLED TRIAL
Maya H Buch, Deepak L Bhatt, Christina Charles-Schoeman, Jon T Giles, Ted Mikuls, Gary G Koch, Steven Ytterberg, Edward Nagy, Hyejin Jo, Kenneth Kwok, Carol A Connell, Karim Richard Masri, Arne Yndestad
OBJECTIVES: Compare the risk of extended major adverse cardiovascular (CV) event (MACE) composite outcomes and component events in patients with rheumatoid arthritis (RA) treated with tofacitinib versus tumour necrosis factor inhibitors (TNFi) in Oral Rheumatoid Arthritis Trial (ORAL) Surveillance. METHODS: Patients with RA aged ≥50 years and with ≥1 additional CV risk factor received tofacitinib 5 mg or 10 mg two times per day or TNFi...
April 12, 2024: RMD Open
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