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RMD Open

Philip J Mease, Arthur Kavanaugh, Andreas Reimold, Hasan Tahir, Jürgen Rech, Stephen Hall, Piet Geusens, Pascale Pellet, Evie Maria Delicha, Shephard Mpofu, Luminita Pricop
Objective: To assess the long-term (3 year) efficacy and safety of secukinumab in patients with active psoriatic arthritis (PsA) in the extension phase of the FUTURE 1 study (NCT01892436). Methods: Following the 2-year core trial, eligible patients receiving subcutaneous secukinumab 150 or 75 mg entered a 3-year extension phase. Results are presented for key efficacy and safety endpoints at week 156. Results: In total, 460 patients entered the extension study; 308 patients originally randomised to secukinumab were assessed for efficacy...
2018: RMD Open
Jan Leipe, Lisa A Christ, Andreas P Arnoldi, Erik Mille, Frank Berger, Markus Heppt, Ilana Goldscheider, Diego Kauffmann-Guerrero, Rudolf M Huber, Claudia Dechant, Carola Berking, Hendrik Schulze-Koops, Alla Skapenko
Immune checkpoint inhibitors (ICIs) may cause immune-related adverse events (IRAEs). Characterisation and data on treatment of musculoskeletal IRAEs are scarce. In this cohort study, patients receiving ICI therapy who experienced arthralgia were evaluated for the presence of synovitis. Data on demographics, ICI regime, time of onset, imaging and response to therapy of synovitis were prospectively collected. Arthritis was demonstrated in 14 of 16 patients of whom 7 showed monarthritis, 5 had oligoarthritis and 2 had polyarthritis...
2018: RMD Open
Cecile Poulain, Maria Antonietta D'Agostino, Severine Thibault, Jean Pierre Daures, Salah Ferkal, Philippe Le Corvoisier, Alain Rahmouni, Damien Loeuille, Maxime Dougados, Pascal Claudepierre
Early diagnosis of axial spondyloarthritis (axSpA) remains a challenge due to the lack of specificity of clinical symptoms and variable prevalence of axial imaging findings permitting a definite diagnosis. Power Doppler ultrasonography (PDUS) of the entheses has demonstrated to be a potential useful tool for the classification and diagnostic management of early SpA independently of the phenotype. Objectives: To assess the classification value (sensitivity and specificity) of PDUS-defined enthesitis for identifying patients fulfilling Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axSpA (ASAS+) in patients with recent inflammatory back pain (IBP) (the DESIR (DEvenir des Spondylarthropathies Indifférenciées Récentes) cohort)...
2018: RMD Open
Joseph F Merola, Luis R Espinoza, Roy Fleischmann
Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) have key differences in clinical presentation, radiographic findings, comorbidities and pathogenesis to distinguish between these common forms of chronic inflammatory arthritis. Joint involvement is typically, but not always, asymmetric in PsA, while it is predominantly symmetric in RA. Bone erosions, without new bone growth, and cervical spine involvement are distinctive of RA, while axial spine involvement, psoriasis and nail dystrophy are distinctive of PsA...
2018: RMD Open
Armaghan Mahmoudian, Dieter Van Assche, Walter Herzog, Frank P Luyten
Osteoarthritis (OA) of the knee is the most common arthritic disease, yet a convincing drug treatment is not available. The current narrative review focuses on integration of scientific evidence and professional experience to illustrate which management approaches can be taken for prototypical individual patient profiles with early knee OA. Animal models suggest that: (1) OA can progress even in the presence of fully recovered movement kinetics, kinematics and muscle activation patterns; (2) muscle weakness is an independent risk factor for the onset and possibly the rate of progression of knee OA; (3) onset and progression of OA are not related to body weight but appear to depend on the percentage of body fat...
2018: RMD Open
Matthieu Lavielle, Déborah Puyraimond-Zemmour, Xavier Romand, Laure Gossec, Eric Senbel, Sophie Pouplin, Catherine Beauvais, Loriane Gutermann, Maryse Mezieres, Maxime Dougados, Anna Molto
Objective: Lack of adherence to treatment is frequent in chronic inflammatory rheumatic diseases and is associated with poorer outcomes. The objective of this study was to describe and evaluate interventions that have been proposed to enhance medication adherence in these conditions. Methods: A systematic literature review was performed in Pubmed, Cochrane, Embase and databases completed by the rheumatology meeting (ACR, EULAR and SFR) abstracts from last 2 years...
2018: RMD Open
Veerle Ide, Xavier Bossuyt, Daniël Blockmans, Ellen De Langhe
Objective: As rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPAs) are not routinely tested in idiopathic inflammatory myositis (IIM), little is known about their prevalence and clinical implications in this patient group. In antisynthetase syndrome (ASS), presence of ACPA is reportedly associated with more severe and erosive arthritis. We aim to retrospectively determine the prevalence of RF and ACPA in a cross-sectional cohort of 121 patients diagnosed with IIM and to assess clinical associations...
2018: RMD Open
Jasvinder A Singh, John D Cleveland
Objective: To assess the association of gout with new-onset atrial fibrillation (AF) in the elderly. Methods: We used the 5% Medicare data from 2005 to 2012 to assess whether a diagnosis of gout was associated with incident AF. We used multivariable Cox regression adjusted for demographics, Charlson-Romano comorbidity index, common cardiovascular medications, allopurinol and febuxostat use, to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Among 1 647 812 eligible people, 9...
2018: RMD Open
Bente Glintborg, Jan Sørensen, Merete Lund Hetland
Objectives: National Danish guidelines in May 2015 dictated a mandatory switch from originator infliximab (INX) to biosimilar CT-P13 in patients with inflammatory rheumatic disease. We investigated if this non-medical switch changed use of outpatient hospital resources. Methods: Observational cohort study. Switchers were identified in DANBIO. Rheumatic outpatient contacts, visits and services were identified in the National Patient Registry. The 6-month rate for (1) number of visits (or services) and (2) days with ≥1 visit (or service) were compared before/after switching (paired t-tests)...
2018: RMD Open
Lucas L van den Hoogen, Giovanni Palla, Cornelis P J Bekker, Ruth D E Fritsch-Stork, Timothy R D J Radstake, Joel A G van Roon
No abstract text is available yet for this article.
2018: RMD Open
Heike A Bischoff-Ferrari, E John Orav, Andreas Egli, Bess Dawson-Hughes, Karina Fischer, Hannes B Staehelin, Rene Rizzoli, Juerg Hodler, Arnold von Eckardstein, Gregor Freystaetter, Ursina Meyer, Thomas Guggi, Peter Burckhardt, Simeon Schietzel, Patricia Chocano-Bedoya, Robert Theiler, Walter C Willett, David Felson
Objective: To test whether daily high-dose vitamin D improves recovery after unilateral total knee replacement. Methods: Data come from a 24-month randomised, double-blind clinical trial. Adults aged 60 and older undergoing unilateral joint replacement due to severe knee osteoarthritis were 6-8 weeks after surgery randomly assigned to receive daily high-dose (2000 IU) or standard-dose (800 IU) vitamin D3 . The primary endpoints were symptoms (Western Ontario and McMaster Universities Arthritis Index pain and function scores) assessed at baseline, 6, 12, 18 and 24 months in both knees, and the rate of falls over 24 months...
2018: RMD Open
Isabelle A Vallerand, Ryan T Lewinson, Alexandra D Frolkis, Mark W Lowerison, Gilaad G Kaplan, Mark G Swain, Andrew G M Bulloch, Scott B Patten, Cheryl Barnabe
Objectives: Major depressive disorder (MDD) is associated with increased levels of systemic proinflammatory cytokines, including tumour necrosis factor alpha. As these cytokines are pathogenic in autoimmune diseases such as rheumatoid arthritis (RA), our aim was to explore on a population-level whether MDD increases the risk of developing RA. Methods: A retrospective cohort study was conducted using The Health Improvement Network (THIN) database (from 1986 to 2012)...
2018: RMD Open
Alberto Cauli, Grazia Dessole, Matteo Piga, Maria Maddalena Angioni, Silvia Pinna, Alberto Floris, Mattia Congia, Enrico Mascia, Fabiana Paladini, Valentina Tedeschi, Rosa Sorrentino, Maria Teresa Fiorillo, Alessandro Mathieu
Background: Ankylosing spondylitis (AS) is a complex chronic inflammatory disease strongly associated with the majority of human leucocyte antigen (HLA)-B27 alleles. HLA-E molecules are non-classical major histocompatibility complex (MHC) class I molecules that specifically interact with the natural killer receptors NKG2A (inhibitory) and NKG2C (activating), and have been recently proposed to be involved in AS pathogenesis.''. Objective: To analyse the expression of HLA-E and the CD94/NKG2 pair of receptors in HLA-B27-positive patients with AS and healthy controls (HC) bearing the AS-associated B*2705 and the non-AS-associated B*2709 alleles...
2018: RMD Open
George A Karpouzas, Vibeke Strand, Sarah R Ormseth
Objective: Patients and physicians commonly differ in their assessments of rheumatoid arthritis (RA) activity. Clinically meaningful discordance thresholds or validation of their ability to predict functional outcomes are lacking. We explored whether an unbiased, person-centred latent profile analysis (LPA) approach could classify cases based on patient global assessment (PtGA) and physician global assessment (MDGA) assessments of RA activity. We further examined whether the LPA groups displayed greater differences in clinical outcomes compared with traditional threshold-based groups...
2018: RMD Open
Casper Webers, Laura Vanhoof, Simon van Genderen, Liesbeth Heuft, Mart van de Laar, Jolanda Luime, Désirée van der Heijde, Floris A van Gaalen, Anneke Spoorenberg, Annelies Boonen
Objectives: To update the knowledge on employment and the role of mastery, a personal factor reflecting the level of control over life and disease, among Dutch patients with ankylosing spondylitis (AS) compared to general population subjects. Methods: Data of persons ≤65 years participating in a Dutch cross-sectional multicentre study on social participation in AS were used. Being employed was the main outcome. Standardised employment ratios (SERs) were calculated using indirect standardisation after adjusting for age, gender and education and repeated after stratification by symptom duration tertiles...
2018: RMD Open
Margarida Rodrigues Santos, Ana Rita Couto, Iris Foroni, Bruno Filipe Bettencourt, Zhixiu Li, Raquel Meneses, Lawrie Wheeler, Joaquim Pereira, Fernando Pimentel-Santos, João Eurico Fonseca, Helena Alves, António Martinho, Manuela Lima, Matthew A Brown, Jácome Bruges-Armas
Objectives: Ankylosing spondylitis (AS) is the most prevalent form of spondyloarthritis, with a known genetic association with the HLA-B27 molecule. The aim of this study was to assess the contribution of the HLA-G, HLA-E and HLA-F to AS susceptibility/protection in Portuguese patients with HLA-B27 AS and HLA-B27 unaffected controls. Methods: High-resolution typing of HLA-G , HLA-E and HLA-F was performed in 228 patients with HLA-B27 AS and 244 HLA-B27 unaffected controls...
2018: RMD Open
Dafna D Gladman, Arthur Kavanaugh, Juan J Gómez-Reino, Jürgen Wollenhaupt, Maurizio Cutolo, Georg Schett, Eric Lespessailles, Benoit Guerette, Nikolay Delev, Lichen Teng, Christopher J Edwards, Charles A Birbara, Philip J Mease
Objective: The Psoriatic Arthritis Long-term Assessment of Clinical Efficacy (PALACE) clinical trial programme findings demonstrated that apremilast, an oral phosphodiesterase 4 inhibitor, is effective for treating psoriatic arthritis (PsA). Enthesitis and dactylitis are difficult-to-treat features of PsA leading to disability and affecting quality of life. PALACE 1, 2 and 3 data were pooled to assess the efficacy of apremilast on enthesitis and dactylitis outcomes in patients with these conditions at baseline...
2018: RMD Open
Jasmijn F M Holla, Marian H van Beers-Tas, Lotte A van de Stadt, Robert Landewé, Jos W R Twisk, Joost Dekker, Dirkjan van Schaardenburg
Objective: Studies on the role of psychosocial vulnerability in the development of arthritis must be performed early in the disease course to exclude the reverse explanation that arthritis leads to psychological symptoms. Therefore, the objective of this study was to investigate the longitudinal (5-year) association between depressive mood, daily stressors, avoidance coping and social support as predictors, and the development of arthritis and other clinical parameters as outcomes, in persons with seropositive arthralgia at risk of developing rheumatoid arthritis...
2018: RMD Open
Agnete Malm Gulati, Brigitte Michelsen, Andreas Diamantopoulos, Berit Grandaunet, Øyvind Salvesen, Arthur Kavanaugh, Mari Hoff, Glenn Haugeberg
Background: The risk of osteoporosis in patients with psoriatic arthritis (PsA) still remains unclear. The aim of this study was to investigate bone mineral density (BMD) at the hip and lumbar spine measured by dual-energy X-ray absorptiometry in patients with PsA. Methods: From an outpatient clinic in southern Norway, 140 patients with PsA were consecutively recruited and assessed for osteoporosis as part of a prospective study from January 2013 to May 2014...
2018: RMD Open
Ulrich A Walker, Lesley Ann Saketkoo, Oliver Distler
Three randomised controlled trials of haematopoietic stem cell transplantation (HSCT) in systemic sclerosis (SSc) demonstrated long-term survival benefits, induction of clinically meaningful, sustained improvement of forced vital capacity with improvements in skin thickening, vasculopathy and health-related quality of life, in contrast to a clinical decline in standard of care control groups. These benefits, however, must be weighed against the increased risk of transplant-related mortality. Further, with disease progression, severe extensive internal organ involvement and damage ensues, constituting an exclusion criterion for safety reasons, leaving a limited window whereby patients with SSc are eligible for HSCT...
2018: RMD Open
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