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https://www.readbyqxmd.com/read/29119008/discordant-patient-physician-assessments-of-disease-activity-and-its-persistence-adversely-impact-quality-of-life-and-work-productivity-in-us-hispanics-with-rheumatoid-arthritis
#1
George A Karpouzas, Sera N Ramadan, Chelsie E Cost, Taylor L Draper, Elizabeth Hernandez, Vibeke Strand, Sarah R Ormseth
Objective: This study was designed to evaluate the determinants of patient and physician global assessments (PtGA and MDGA, respectively) of disease activity, their discordance and change over 2 years in Hispanics with rheumatoid arthritis (RA). We further examined the impact of discordance and its persistence on health-related quality of life (HRQOL) and work productivity on final visit. Methods: We studied 536 Hispanics with established RA from a single centre...
2017: RMD Open
https://www.readbyqxmd.com/read/29119007/endothelial-dysfunction-is-associated-with-activation-of-the-type-i-interferon-system-and-platelets-in-patients-with-systemic-lupus-erythematosus
#2
Helena Tydén, Christian Lood, Birgitta Gullstrand, Christoffer Tandrup Nielsen, Niels H H Heegaard, Robin Kahn, Andreas Jönsen, Anders A Bengtsson
Objectives: Endothelial dysfunction may be connected to cardiovascular disease (CVD) in systemic lupus erythematosus (SLE). Type I interferons (IFNs) are central in SLE pathogenesis and are suggested to induce both endothelial dysfunction and platelet activation. In this study, we investigated the interplay between endothelial dysfunction, platelets and type I IFN in SLE. Methods: We enrolled 148 patients with SLE and 79 sex-matched and age-matched healthy controls (HCs)...
2017: RMD Open
https://www.readbyqxmd.com/read/29119006/cost-utility-of-cobra-light-versus-cobra-therapy-in-patients-with-early-rheumatoid-arthritis-the-cobra-light-trial
#3
Marieke M Ter Wee, Veerle Mh Coupé, Debby den Uyl, Birgit S Blomjous, Esmee Kooijmans, Pit Jsm Kerstens, Mike T Nurmohamed, Dirkjan van Schaardenburg, Alexandre E Voskuyl, Maarten Boers, Willem F Lems
Objective: To evaluate if COmbinatie therapie Bij Reumatoïde Artritis (COBRA)-light therapy is cost-effective in treating patients with early rheumatoid arthritis (RA) compared with COBRA therapy. Methods: This economic evaluation was performed next to the open-label, randomised non-inferiority COBRA-light trial in 164 patients with early RA. Non-responders to COBRA or COBRA-light received etanercept (50 mg/week) for 3-6 months. The societal perspective analysis took medical direct, non-medical direct and indirect costs into account...
2017: RMD Open
https://www.readbyqxmd.com/read/29081988/infection-rates-in-patients-from-five-rheumatoid-arthritis-ra-registries-contextualising-an-ra-clinical-trial-programme
#4
Hisashi Yamanaka, Johan Askling, Niklas Berglind, Stefan Franzen, Thomas Frisell, Christopher Garwood, Jeffrey D Greenberg, Meilien Ho, Marie Holmqvist, Laura Novelli Horne, Eisuke Inoue, Kaleb Michaud, Dimitrios A Pappas, George Reed, Deborah Symmons, Eiichi Tanaka, Trung N Tran, Suzanne M M Verstappen, Eveline Wesby-van Swaay, Fredrik Nyberg
OBJECTIVE: Patients with rheumatoid arthritis (RA) have an increased risk of serious infections. Comparing infection rates across RA populations is complicated by differences in background infection risk, population composition and study methodology. We measured infection rates from five RA registries globally, with the aim to contextualise infection rates from an RA clinical trials population. METHODS: We used data from Consortium of Rheumatology Research of North America (CORRONA) (USA), Swedish Rheumatology Quality of Care Register (Sweden), Norfolk Arthritis Register (UK), CORRONA International (multiple countries) and Institute of Rheumatology Rheumatoid Arthritis (Japan) and an RA clinical trial programme (fostamatinib)...
2017: RMD Open
https://www.readbyqxmd.com/read/29081987/synovial-fibroblasts-in-2017
#5
REVIEW
Caroline Ospelt
Stromal cells like synovial fibroblasts gained great interest over the years, since it has become clear that they strongly influence their environment and neighbouring cells. The current review describes the role of synovial fibroblasts as cells of the innate immune system and expands on their involvement in inflammation and cartilage destruction in rheumatoid arthritis (RA). Furthermore, epigenetic changes in RA synovial fibroblasts and studies that focused on the identification of different subsets of synovial fibroblasts are discussed...
2017: RMD Open
https://www.readbyqxmd.com/read/29071120/safety-and-efficacy-of-baricitinib-in-elderly-patients-with-rheumatoid-arthritis
#6
Roy Fleischmann, Jahangir Alam, Vipin Arora, John Bradley, Douglas E Schlichting, David Muram, Josef S Smolen
No abstract text is available yet for this article.
2017: RMD Open
https://www.readbyqxmd.com/read/29071119/switching-biological-disease-modifying-antirheumatic-drugs-in-patients-with-axial-spondyloarthritis-results-from-a-systematic-literature-review
#7
Victoria Navarro-Compán, Chamaida Plasencia-Rodríguez, Eugenio de Miguel, Petra Diaz Del Campo, Alejandro Balsa, Jordi Gratacós
OBJECTIVES: First, to investigate if switching biological disease-modifying antirheumatic drugs (bDMARDs) after the failure to prior bDMARD is efficacious in patients with axial spondyloarthritis (axSpA). Second, to evaluate the influence on this efficacy of (1) the reason to discontinue prior tumour necrosis factor inhibitor (TNFi), (2) changing the type of TNFi and (3) changing the target. METHODS: A systematic literature review until January 2017 was performed using Medline, EMBASE and Cochrane databases...
2017: RMD Open
https://www.readbyqxmd.com/read/29071118/influence-of-aromatase-inhibitors-therapy-on-the-occurrence-of-rheumatoid-arthritis-in-women-with-breast-cancer-results-from-a-large-population-based-study-of-the-italian-society-for-rheumatology
#8
Marta Caprioli, Greta Carrara, Garifallia Sakellariou, Ettore Silvagni, Carlo Alberto Scirè
OBJECTIVES: The purpose of this study was to evaluate the risk of developing rheumatoid arthritis (RA) in a population of patients with breast cancer treated with aromatase inhibitors (AIs) compared with tamoxifen. METHODS: Data were collected from the administrative healthcare database of Lombardy Region, Italy, from 2004 to 2013. This study follows a nested cohort design, including women with a diagnosis of breast cancer starting treatment with tamoxifen, anastrozole, exemestane or letrozole...
2017: RMD Open
https://www.readbyqxmd.com/read/29071117/variants-of-genes-implicated-in-type-1-interferon-pathway-and-b-cell-activation-modulate-the-eular-response-to-rituximab-at-24-weeks-in-rheumatoid-arthritis
#9
Pierre-Antoine Juge, Steven Gazal, Arnaud Constantin, Xavier Mariette, Bernard Combe, Jacques Tebib, Maxime Dougados, Jean Sibilia, Xavier Le Loet, Philippe Dieudé
BACKGROUND: The type 1 interferon (IFN) pathway has been identified to potentially affect the response to rituximab (RTX) for rheumatoid arthritis (RA), which suggests the contribution of type 1 IFN pathway genes such as IFN regulatory factor 5 and 7 (IRF5 and IRF7), tyrosine kinase 2 (TYK2), signal transducer and activator of transcription 4 (STAT4) and osteopontin (SPP1). Our objective was to study functional variants of these IFN pathway genes as predictors of the European League Against Rheumatism (EULAR) response to RTX for RA at week 24 (W24)...
2017: RMD Open
https://www.readbyqxmd.com/read/29018568/person-focused-care-for-young-people-with-rheumatic-and-musculoskeletal-diseases-young-rheumatologists-and-eular-young-pare-perspectives
#10
Alessia Alunno, Paul Studenic, Elena Nikiphorou, Petra Balážová, Linda van Nieuwkoop, Sofia Ramiro, Francesco Carubbi, Christophe Richez, Nele Caeyers, Laure Gossec, Marios Kouloumas
In recent years, the evolution of healthcare challenged the management of people with rheumatic and musculoskeletal diseases (RMDs). From disease-centred care to person-focused care, a holistic approach along with patient empowerment about their disease, improved the physician-patient relationship and allowed to achieve better outcomes with lower healthcare costs. Nevertheless, RMDs may occur from childhood to the old age and to date very few studies have addressed the needs and priorities of young people with RMDs...
2017: RMD Open
https://www.readbyqxmd.com/read/29018567/do-we-need-bone-mineral-density-to-estimate-osteoporotic-fracture-risk-a-10-year-prospective-multicentre-validation-study
#11
Andréa Marques, Raquel Lucas, Eugénia Simões, Suzanne M M Verstappen, Johannes W G Jacobs, Jose A P da Silva
OBJECTIVE: Evaluate the performance of FRAX®, with and without bone mineral densitometry (BMD), in predicting the occurrence of fragility fractures over 10 years. METHODS: Participants aged ≥40 years at baseline, with a complete set of data and a minimum of 8.5 years of follow-up were identified from three cohorts (n=2626). Ten-year fracture risk at baseline were estimated with FRAX® and assessed by comparison with observed fractures and receiver operating characteristic analysis...
2017: RMD Open
https://www.readbyqxmd.com/read/29018566/risks-of-smoking-and-benefits-of-smoking-cessation-on-hospitalisations-for-cardiovascular-events-and-respiratory-infection-in-patients-with-rheumatoid-arthritis-a-retrospective-cohort-study-using-the-clinical-practice-research-datalink
#12
Rebecca M Joseph, Mohammad Movahedi, William G Dixon, Deborah Pm Symmons
OBJECTIVES: To investigate the associations between smoking status, smoking cessation and hospitalisations for cardiovascular events (CVE) and respiratory tract infections (RTI) in an inception cohort of patients with rheumatoid arthritis (RA). METHODS: The study was set within UK primary care electronic health records (the Clinical Practice Research Datalink) linked to hospital inpatient data (Hospital Episode Statistics). Patients with RA were followed from diagnosis to hospitalisation with a record of CVE or RTI, leaving their general practice, death, or 10 January 2012, whichever was earliest...
2017: RMD Open
https://www.readbyqxmd.com/read/29018565/health-related-quality-of-life-and-depression-among-participants-in-the-sj%C3%A3-gren-s-international-collaborative-clinical-alliance-registry
#13
Annie Chou, John A Gonzales, Troy E Daniels, Lindsey A Criswell, Stephen C Shiboski, Caroline H Shiboski
OBJECTIVE: To examine health-related quality of life (HRQoL) and depression among participants in an international Sjögren's syndrome (SS) registry, comparing those with and without SS. METHODS: Cross-sectional study of participants in the Sjögren's International Collaborative Clinical Alliance (SICCA) registry. The 2016 American College of Rheumatology/European League Against Rheumatism SS classification criteria were used to determine disease status. HRQoL was assessed using the Short Form 12, version 2 Health Survey to derive scores for physical component summary (PCS) and mental component summary (MCS)...
2017: RMD Open
https://www.readbyqxmd.com/read/29018564/achieving-comprehensive-disease-control-in-patients-with-early-and-established-rheumatoid-arthritis-treated-with-adalimumab-plus-methotrexate-versus-methotrexate-alone
#14
Edward C Keystone, Ferdinand C Breedveld, Désirée van der Heijde, Ronald F van Vollenhoven, Paul Emery, Josef S Smolen, Iain Sainsbury, Stefan Florentinus, Hartmut Kupper, Kun Chen, Arthur Kavanaugh
OBJECTIVE: To evaluate the achievement of comprehensive disease control (CDC) following 1 year of treatment with adalimumab+methotrexate versus methotrexate alone and whether early achievement of remission (at week 24 or 26) is associated with CDC at week 52 in patients with either early or established rheumatoid arthritis (RA). METHODS: Post hoc analyses were conducted in three clinical studies assessing treatment with adalimumab+methotrexate: DE019 (NCT00195702) enrolled patients with established RA who were methotrexate inadequate responders; OPTIMA (NCT00420927) and PREMIER (NCT00195663) enrolled methotrexate-naive patients with early RA...
2017: RMD Open
https://www.readbyqxmd.com/read/28959455/distinct-features-distinguishing-igg4-related-disease-from-multicentric-castleman-s-disease
#15
Takanori Sasaki, Mitsuhiro Akiyama, Yuko Kaneko, Takehiko Mori, Hidekata Yasuoka, Katsuya Suzuki, Kunihiro Yamaoka, Shinichiro Okamoto, Tsutomu Takeuchi
OBJECTIVES: Differentiating IgG4-related disease (IgG4-RD) from multicentric Castleman's disease (MCD) is challenging because both diseases present high serum IgG4. The objective of this study is to clarify the differences in characteristics and identify a clinically useful approach to differentiate these two diseases. METHODS: Forty-five consecutive patients with untreated active IgG4-RD and 33 patients with MCD were included in this study, who visited our institution from January 2000 to August 2016...
2017: RMD Open
https://www.readbyqxmd.com/read/28955501/associations-between-coronary-and-carotid-artery-atherosclerosis-in-patients-with-inflammatory-joint-diseases
#16
Mona Svanteson, Silvia Rollefstad, Nils Einar Kløw, Jonny Hisdal, Eirik Ikdahl, Anne Grete Semb, Ylva Haig
OBJECTIVE: Low association between cardiac symptoms and coronary artery disease (CAD) in patients with inflammatory joint diseases (IJD) demands for objective markers to improve cardiovascular risk stratification. Our main aim was to evaluate the prevalence and characteristics of CAD in patients with IJD with carotid artery plaques. Furthermore, we aimed to assess associations of carotid ultrasonographic findings and coronary plaques. METHODS: Eighty-six patients (61% female) with IJD (55 with rheumatoid arthritis, 21 with ankylosing spondylitis and 10 with psoriatic arthritis) and carotid artery plaque were referred to coronary CT angiography (CCTA)...
2017: RMD Open
https://www.readbyqxmd.com/read/28955500/environmental-and-lifestyle-factors-influencing-risk-of-congenital-heart-block-during-pregnancy-in-anti-ro-ssa-positive-women
#17
Sabrina Meisgen, Joanna Tingström, Amanda Skog Andreasson, Sven-Erik Sonesson, Ingrid Kockum, Marie Wahren-Herlenius
OBJECTIVES: Congenital heart block (CHB) occurs in 1%-2% of anti-Ro/SSA antibody-positive pregnancies. A population-based recurrence rate of 12% indicates that factors other than maternal autoantibodies influence CHB development. Here we report the first investigation to identify environmental and lifestyle factors influencing the risk of CHB. METHODS: A questionnaire focused on environmental and lifestyle factors was distributed to anti-Ro/SSA antibody-positive women who had given birth to at least one child with CHB, and additional data were retrieved from national health registers...
2017: RMD Open
https://www.readbyqxmd.com/read/28955499/impact-of-tocilizumab-monotherapy-on-patient-reported-outcomes-in-patients-with-rheumatoid-arthritis-from-two-randomised-controlled-trials
#18
Vibeke Strand, Margaret Michalska, Christine Birchwood, Jinglan Pei, Katie Tuckwell, Rebecca Finch, Cem Gabay, Arthur Kavanaugh, Graeme Jones
OBJECTIVE: Two randomised controlled trials, AMBITION (NCT00109408) and ADACTA (NCT01119859), showed tocilizumab (TCZ) monotherapy superior to methotrexate (MTX) and adalimumab (ADA) monotherapy, respectively, for improving rheumatoid arthritis (RA) disease activity. This study compared the benefit of TCZ versus MTX or ADA monotherapy for improving patient-reported outcomes (PROs) in patients with RA. METHODS: PROs included patient global assessment (PtGA), pain, Health Assessment Questionnaire Disability Index (HAQ-DI), Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue and Short Form-36 (SF-36) physical component summary (PCS) and mental component summary (MCS) and eight domain scores...
2017: RMD Open
https://www.readbyqxmd.com/read/28955498/switching-from-originator-biological-agents-to-biosimilars-what-is-the-evidence-and-what-are-the-issues
#19
EDITORIAL
Eric Toussirot, Hubert Marotte
No abstract text is available yet for this article.
2017: RMD Open
https://www.readbyqxmd.com/read/28955497/pneumococcal-vaccination-in-autoimmune-rheumatic-diseases
#20
REVIEW
Éva Rákóczi, Zoltan Szekanecz
Streptococcus pneumoniae is the leading cause of the community-acquired pneumonia. The mortality rate of invasive pneumococcal infections is high. Immunocompromised patients suffering from autoimmune inflammatory rheumatic diseases (AIRD) have a high risk for acquiring these infections. Protection against infection can be improved with vaccination. After using polysaccharide vaccines (PPV-23), in July 2013, a 13-valent conjugate vaccine (PCV-13) was approved for adults. Due to its conjugate form, this vaccine is the recommended choice in pneumococcal vaccine-naive patients...
2017: RMD Open
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