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RMD Open

Jasvinder A Singh, John D Cleveland
Objective: To assess the association of gout with new-onset atrial fibrillation (AF) in the elderly. Methods: We used the 5% Medicare data from 2005 to 2012 to assess whether a diagnosis of gout was associated with incident AF. We used multivariable Cox regression adjusted for demographics, Charlson-Romano comorbidity index, common cardiovascular medications, allopurinol and febuxostat use, to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Among 1 647 812 eligible people, 9...
2018: RMD Open
Bente Glintborg, Jan Sørensen, Merete Lund Hetland
Objectives: National Danish guidelines in May 2015 dictated a mandatory switch from originator infliximab (INX) to biosimilar CT-P13 in patients with inflammatory rheumatic disease. We investigated if this non-medical switch changed use of outpatient hospital resources. Methods: Observational cohort study. Switchers were identified in DANBIO. Rheumatic outpatient contacts, visits and services were identified in the National Patient Registry. The 6-month rate for (1) number of visits (or services) and (2) days with ≥1 visit (or service) were compared before/after switching (paired t-tests)...
2018: RMD Open
Lucas L van den Hoogen, Giovanni Palla, Cornelis P J Bekker, Ruth D E Fritsch-Stork, Timothy R D J Radstake, Joel A G van Roon
No abstract text is available yet for this article.
2018: RMD Open
Heike A Bischoff-Ferrari, E John Orav, Andreas Egli, Bess Dawson-Hughes, Karina Fischer, Hannes B Staehelin, Rene Rizzoli, Juerg Hodler, Arnold von Eckardstein, Gregor Freystaetter, Ursina Meyer, Thomas Guggi, Peter Burckhardt, Simeon Schietzel, Patricia Chocano-Bedoya, Robert Theiler, Walter C Willett, David Felson
Objective: To test whether daily high-dose vitamin D improves recovery after unilateral total knee replacement. Methods: Data come from a 24-month randomised, double-blind clinical trial. Adults aged 60 and older undergoing unilateral joint replacement due to severe knee osteoarthritis were 6-8 weeks after surgery randomly assigned to receive daily high-dose (2000 IU) or standard-dose (800 IU) vitamin D3 . The primary endpoints were symptoms (Western Ontario and McMaster Universities Arthritis Index pain and function scores) assessed at baseline, 6, 12, 18 and 24 months in both knees, and the rate of falls over 24 months...
2018: RMD Open
Isabelle A Vallerand, Ryan T Lewinson, Alexandra D Frolkis, Mark W Lowerison, Gilaad G Kaplan, Mark G Swain, Andrew G M Bulloch, Scott B Patten, Cheryl Barnabe
Objectives: Major depressive disorder (MDD) is associated with increased levels of systemic proinflammatory cytokines, including tumour necrosis factor alpha. As these cytokines are pathogenic in autoimmune diseases such as rheumatoid arthritis (RA), our aim was to explore on a population-level whether MDD increases the risk of developing RA. Methods: A retrospective cohort study was conducted using The Health Improvement Network (THIN) database (from 1986 to 2012)...
2018: RMD Open
Alberto Cauli, Grazia Dessole, Matteo Piga, Maria Maddalena Angioni, Silvia Pinna, Alberto Floris, Mattia Congia, Enrico Mascia, Fabiana Paladini, Valentina Tedeschi, Rosa Sorrentino, Maria Teresa Fiorillo, Alessandro Mathieu
Background: Ankylosing spondylitis (AS) is a complex chronic inflammatory disease strongly associated with the majority of human leucocyte antigen (HLA)-B27 alleles. HLA-E molecules are non-classical major histocompatibility complex (MHC) class I molecules that specifically interact with the natural killer receptors NKG2A (inhibitory) and NKG2C (activating), and have been recently proposed to be involved in AS pathogenesis.''. Objective: To analyse the expression of HLA-E and the CD94/NKG2 pair of receptors in HLA-B27-positive patients with AS and healthy controls (HC) bearing the AS-associated B*2705 and the non-AS-associated B*2709 alleles...
2018: RMD Open
George A Karpouzas, Vibeke Strand, Sarah R Ormseth
Objective: Patients and physicians commonly differ in their assessments of rheumatoid arthritis (RA) activity. Clinically meaningful discordance thresholds or validation of their ability to predict functional outcomes are lacking. We explored whether an unbiased, person-centred latent profile analysis (LPA) approach could classify cases based on patient global assessment (PtGA) and physician global assessment (MDGA) assessments of RA activity. We further examined whether the LPA groups displayed greater differences in clinical outcomes compared with traditional threshold-based groups...
2018: RMD Open
Casper Webers, Laura Vanhoof, Simon van Genderen, Liesbeth Heuft, Mart van de Laar, Jolanda Luime, Désirée van der Heijde, Floris A van Gaalen, Anneke Spoorenberg, Annelies Boonen
Objectives: To update the knowledge on employment and the role of mastery, a personal factor reflecting the level of control over life and disease, among Dutch patients with ankylosing spondylitis (AS) compared to general population subjects. Methods: Data of persons ≤65 years participating in a Dutch cross-sectional multicentre study on social participation in AS were used. Being employed was the main outcome. Standardised employment ratios (SERs) were calculated using indirect standardisation after adjusting for age, gender and education and repeated after stratification by symptom duration tertiles...
2018: RMD Open
Margarida Rodrigues Santos, Ana Rita Couto, Iris Foroni, Bruno Filipe Bettencourt, Zhixiu Li, Raquel Meneses, Lawrie Wheeler, Joaquim Pereira, Fernando Pimentel-Santos, João Eurico Fonseca, Helena Alves, António Martinho, Manuela Lima, Matthew A Brown, Jácome Bruges-Armas
Objectives: Ankylosing spondylitis (AS) is the most prevalent form of spondyloarthritis, with a known genetic association with the HLA-B27 molecule. The aim of this study was to assess the contribution of the HLA-G, HLA-E and HLA-F to AS susceptibility/protection in Portuguese patients with HLA-B27 AS and HLA-B27 unaffected controls. Methods: High-resolution typing of HLA-G , HLA-E and HLA-F was performed in 228 patients with HLA-B27 AS and 244 HLA-B27 unaffected controls...
2018: RMD Open
Dafna D Gladman, Arthur Kavanaugh, Juan J Gómez-Reino, Jürgen Wollenhaupt, Maurizio Cutolo, Georg Schett, Eric Lespessailles, Benoit Guerette, Nikolay Delev, Lichen Teng, Christopher J Edwards, Charles A Birbara, Philip J Mease
Objective: The Psoriatic Arthritis Long-term Assessment of Clinical Efficacy (PALACE) clinical trial programme findings demonstrated that apremilast, an oral phosphodiesterase 4 inhibitor, is effective for treating psoriatic arthritis (PsA). Enthesitis and dactylitis are difficult-to-treat features of PsA leading to disability and affecting quality of life. PALACE 1, 2 and 3 data were pooled to assess the efficacy of apremilast on enthesitis and dactylitis outcomes in patients with these conditions at baseline...
2018: RMD Open
Jasmijn F M Holla, Marian H van Beers-Tas, Lotte A van de Stadt, Robert Landewé, Jos W R Twisk, Joost Dekker, Dirkjan van Schaardenburg
Objective: Studies on the role of psychosocial vulnerability in the development of arthritis must be performed early in the disease course to exclude the reverse explanation that arthritis leads to psychological symptoms. Therefore, the objective of this study was to investigate the longitudinal (5-year) association between depressive mood, daily stressors, avoidance coping and social support as predictors, and the development of arthritis and other clinical parameters as outcomes, in persons with seropositive arthralgia at risk of developing rheumatoid arthritis...
2018: RMD Open
Agnete Malm Gulati, Brigitte Michelsen, Andreas Diamantopoulos, Berit Grandaunet, Øyvind Salvesen, Arthur Kavanaugh, Mari Hoff, Glenn Haugeberg
Background: The risk of osteoporosis in patients with psoriatic arthritis (PsA) still remains unclear. The aim of this study was to investigate bone mineral density (BMD) at the hip and lumbar spine measured by dual-energy X-ray absorptiometry in patients with PsA. Methods: From an outpatient clinic in southern Norway, 140 patients with PsA were consecutively recruited and assessed for osteoporosis as part of a prospective study from January 2013 to May 2014...
2018: RMD Open
Ulrich A Walker, Lesley Ann Saketkoo, Oliver Distler
Three randomised controlled trials of haematopoietic stem cell transplantation (HSCT) in systemic sclerosis (SSc) demonstrated long-term survival benefits, induction of clinically meaningful, sustained improvement of forced vital capacity with improvements in skin thickening, vasculopathy and health-related quality of life, in contrast to a clinical decline in standard of care control groups. These benefits, however, must be weighed against the increased risk of transplant-related mortality. Further, with disease progression, severe extensive internal organ involvement and damage ensues, constituting an exclusion criterion for safety reasons, leaving a limited window whereby patients with SSc are eligible for HSCT...
2018: RMD Open
Johan L Bloem, Monique Reijnierse, Tom W J Huizinga, Annette H M van der Helm-van Mil
In 2003, the Nobel Prize for Medicine was awarded for contribution to the invention of MRI, reflecting the incredible value of MRI for medicine. Since 2003, enormous technical advancements have been made in acquiring MR images. However, MRI has a complicated, accident-prone dark side; images are not calibrated and respective images are dependent on all kinds of subjective choices in the settings of the machine, acquisition technique parameters, reconstruction techniques, data transmission, filtering and postprocessing techniques...
2018: RMD Open
Alberto Floris, Matteo Piga, Alberto Cauli, Carlo Salvarani, Alessandro Mathieu
No abstract text is available yet for this article.
2018: RMD Open
Ruediger B Mueller, Toni Kaegi, Sarah R Haile, Hendrik Schulze-Koops, Michael Schiff, Johannes von Kempis
Objective: To analyse whether early arthritis patients who do not fulfil the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) 2010 classification criteria for rheumatoid arthritis (RA) have a different course of the disease dependent on whether they can or cannot be classified as RA because of radiographic disease (EULAR task force) at diagnosis. Methods: For this observational study within the Swiss RA cohort SCQM, we included patients with early undifferentiated arthritis (disease duration ≤1 year), who had not received any previous disease-modifying antirheumatic drugs (DMARDs)...
2018: RMD Open
Ramón Mazzucchelli, Elia Pérez Fernandez, Natalia Crespí-Villarías, Javier Quirós-Donate, Alberto García Vadillo, María Espinosa, Marina Peña, Cristina Macía-Villa, Jose Luis Morell-Hita, Cristina Martinez-Prada, Virginia Villaverde, Inmaculada Morado Quiroga, Olalla Guzón-Illescas, Carmen Barbadillo, Manuel Fernández Prada, Hilda Godoy, Angela Herranz Varela, María Galindo Izquierdo, Gil Rodriguez Caravaca
Purpose: To analyse trends in hip fracture (HF) rates in patients with rheumatoid arthritis (RA) over an extended time period (17 years). Methods: This observational retrospective survey was performed by reviewing data from the National Surveillance System for Hospital Data, which includes more than 98% of Spanish hospitals. All hospitalisations of patients with RA and HF that were reported from 1999 to 2015 were analysed. Codes were selected using the Ninth International Classification of Diseases, Clinical Modification: ICD-9-CM: RA 714...
2018: RMD Open
Ruth Costello, Clare Jacklin, Matthew Jameson Evans, John McBeth, William G Dixon
Objectives: To describe (1) the representativeness of (a) users of an online health community ( (HU)) with rheumatoid arthritis (RA) and (b) paid members of an RA patient organisation, the National Rheumatoid Arthritis Society (NRAS), compared with the general RA population; and (2) the willingness of HU users with RA to participate in types of research (surveys, use of an app or activity tracker, and trials). Methods: A pop-up survey was embedded on HU to determine the characteristics of users and their willingness to participate in research...
2018: RMD Open
Freek de Bruin, Marco O Treyvaud, Antoine Feydy, Manouk de Hooge, Jean-Baptiste Pialat, Maxime Dougados, Laure Gossec, Johan L Bloem, Désirée van der Heijde, Monique Reijnierse
Objectives: To describe the prevalence of degenerative changes on MRI and conventional radiographs of the spine in a young population with suspicion of axial spondyloarthritis (axSpA) and assess whether it is possible to discriminate between degenerative changes and lesions associated with axSpA. Methods: Whole spine MRI and cervical and lumbar radiographs of patients ≥18 years with chronic back pain (≥3 months, ≤3 years, onset <50 years) were assessed for degeneration by two readers, and for SpA lesions by two other readers, all blinded for clinical information and results of the other readers...
2018: RMD Open
Edward C Keystone, Ferdinand C Breedveld, Hartmut Kupper, Yihan Li, Stefan Florentinus, Iain Sainsbury
Objective: To evaluate long-term clinical, functional and radiographic outcomes in an open-label extension (OLE) study in patients with rheumatoid arthritis (RA) receiving adalimumab monotherapy or adalimumab+methotrexate following attainment of low disease activity (LDA) with adalimumab+methotrexate. Methods: Methotrexate-naive patients with early RA were randomised to adalimumab, methotrexate or adalimumab +methotrexate in a double-blind, 2-year study. Patients who completed the study and achieved LDA (28-joint Disease Activity Score using C reactive protein (DAS28(CRP)<3...
2018: RMD Open
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