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Clinical Diabetes and Endocrinology

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https://www.readbyqxmd.com/read/30377539/how-is-neighborhood-social-disorganization-associated-with-diabetes-outcomes-a-multilevel-investigation-of-glycemic-control-and-self-reported-use-of-acute-or-emergency-health-care-services
#1
Sarah D Kowitt, Katrina E Donahue, Edwin B Fisher, Madeline Mitchell, Laura A Young
Background: Diabetes management is influenced by a number of factors beyond the individual-level. This study examined how neighborhood social disorganization (i.e., neighborhoods characterized by high economic disadvantage, residential instability, and ethnic heterogeneity), is associated with diabetes-related outcomes. Methods: We used a multilevel modeling approach to investigate the associations between census-tract neighborhood social disorganization, A1c, and self-reported use of acute or emergency health care services for a sample of 424 adults with type 2 diabetes...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/30181896/growth-hormone-isoforms-clinical-aspects-and-assays-interference
#2
REVIEW
Júnia Ribeiro de Oliveira Longo Schweizer, Antônio Ribeiro-Oliveira, Martin Bidlingmaier
The measurement of circulating concentrations of growth hormone (GH) is an indispensable tool in the diagnosis of both GH deficiency and GH excess. GH is a heterogeneous protein composed of several molecular isoforms, but the physiological role of these different isoforms has not yet been fully understood. The 22KD GH (22 K-GH) is the main isoform in circulation, followed by 20KD GH (20 K-GH) and other rare isoforms. Studies have been performed to better understand the biological actions of the different isoforms as well as their importance in pathological conditions...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/30083376/the-journey-continues-in-clinical-diabetes-and-endocrinology
#3
Ariel Barkan, Roma Gianchandani, Meng H Tan
No abstract text is available yet for this article.
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/30009041/current-treatment-strategies-for-patients-with-advanced-gastroenteropancreatic-neuroendocrine-tumors-gep-nets
#4
REVIEW
Inbal Uri, Simona Grozinsky-Glasberg
Background: Neuroendocrine tumors (NETs) are rare neoplasms, with an estimated annual incidence of ~ 6.9/100,000. NETs arise throughout the body from cells of the diffuse endocrine system. More than half originate from endocrine cells of the gastrointestinal tract and the pancreas, thus being referred to as gastroenteropancreatic NETs (GEP NETs). The only treatment that offers a cure is surgery, however most patients are diagnosed with metastatic disease, and curative surgery is usually not an option...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29977594/pheochromocytoma-and-paraganglioma-in-neurofibromatosis-type-1-frequent-surgeries-and-cardiovascular-crises-indicate-the-need-for-screening
#5
Elisabeth Joye Petr, Tobias Else
Background: Pheochromocytomas and Paragangliomas (PCC/PGL) are rare endocrine tumors that are mostly benign, but often hormone producing, causing significant morbidity and mortality due to excess catecholamine secretion and cardiovascular crises. It is estimated that 30% of PCC/PGL are due to germline mutations, including Neurofibromatosis type 1 ( NF1 ). There is little published data describing the phenotype of NF1-associated PCC/PGL and there are no established recommendations for PCC/PGL screening in NF1...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29946482/weight-loss-and-bone-mineral-density-in-obese-adults-a-longitudinal-analysis-of-the-influence-of-very-low-energy-diets
#6
Palak Choksi, Amy Rothberg, Andrew Kraftson, Nicole Miller, Katherine Zurales, Charles Burant, Catherine Van Poznak, Mark Peterson
Background: The long-term effect of weight reduction on skeletal health is not well understood. The purpose of this study was to examine the impact of an intensive medical weight loss intervention using very low energy diet (VLED) (~ 800 cal/day) that result in significant changes in body weight, on total body bone mineral density (BMD) over 2 years. Methods: We examined the impact of VLED-induced weight loss on BMD and FFM (Fat-free Mass) after 3-6 months and again while in weight maintenance at 2 years in 49 subjects...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29946481/rare-clinical-entity-metastatic-malignant-struma-ovarii-diagnosed-during-pregnancy-lessons-for-management
#7
Corey J Lager, Ronald J Koenig, Richard W Lieberman, Anca M Avram
Background: Malignant struma ovarii is an ovarian teratoma containing at least 50% thyroid tissue which has the potential to metastasize and produce thyroid hormone. Given its rarity, management strategies are not well-established. We report a case of metastatic malignant struma ovarii discovered during pregnancy with lessons for evaluation and management. Case presentation: A 30-year-old woman who was two months pregnant was discovered to have struma ovarii with over half of the struma comprised of papillary thyroid cancer...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29862042/the-challenges-of-diagnosing-osteoporosis-and-the-limitations-of-currently-available-tools
#8
REVIEW
Palak Choksi, Karl J Jepsen, Gregory A Clines
Dual-energy X-ray absorptiometry (DXA) was the first imaging tool widely utilized by clinicians to assess fracture risk, especially in postmenopausal women. The development of DXA nearly coincided with the availability of effective osteoporosis medications. Although osteoporosis in adults is diagnosed based on a T-score equal to or below - 2.5 SD, most individuals who sustain fragility fractures are above this arbitrary cutoff. This incongruity poses a challenge to clinicians to identify patients who may benefit from osteoporosis treatments...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29760945/liraglutide-and-dulaglutide-therapy-in-addition-to-sglt-2-inhibitor-and-metformin-treatment-in-indian-type-2-diabetics-a-real-world-retrospective-observational-study
#9
S Ghosal, B Sinha
Background: Therapy for Type 2 diabetes (T2D) has been transformed by the introduction of newer agents like Glucagon like Peptide Receptor Agonists (GLP-1RA) and Sodium-glucose linked transporter inhibitors (SGLT2i). However with co-initiation of SGLT2i and GLP-1RA in the DURATION 8 trial an improvement in HbA1c was noted but the beneficial effect was not equal to the sum of its parts. In view of this we proceeded to test the hypothesis that sequential addition of GLP-1RA therapy to metformin and SGLT-2i may be more beneficial...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29760944/characteristics-of-insulin-na%C3%A3-ve-people-with-type-2-diabetes-who-successfully-respond-to-insulin-glargine-u100-after-24-weeks-of-treatment-a-meta-analysis-of-individual-participant-data-from-3-randomized-clinical-trials
#10
M H Cummings, D Cao, I Hadjiyianni, L L Ilag, M H Tan
Background: To identify baseline/clinical characteristics associated with clinically meaningful responses to insulin glargine 100 U/mL (IGlar) in insulin-naive people with type 2 diabetes mellitus (T2DM). Methods: Individual participant data were pooled from 3 randomized trials to compare baseline characteristics and clinical outcomes associated with 24-week response to IGlar in combination with non-insulin antihyperglycemic agents in participants with T2DM. Responders were defined as achieving endpoint HbA1c target < 53 mmol/mol (< 7%) and/or ≥ 11 mmol/mol (≥ 1%) HbA1c reduction from baseline...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29721333/diabetes-mellitus-and-bone-health-epidemiology-etiology-and-implications-for-fracture-risk-stratification
#11
Rodrigo J Valderrábano, Maria I Linares
Skeletal fractures can result when there are co-morbid conditions that negatively impact bone strength. Fractures represent an important source of morbidity and mortality, especially in older populations. Diabetes mellitus is a metabolic disorder that has reached worldwide epidemic proportions and is increasingly being recognized as a risk factor for fracture. Type 1 and Type 2 diabetes have different effects on bone mineral density but share common pathways, which lead to bone fragility. In this review, we discuss the available data on diabetes and fractures, bone density and the clinical implications for fracture risk stratification in current practice...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29682315/insulin-therapy-for-type-2-diabetes-are-we-there-yet-the-d-nav%C3%A2-story
#12
I Hodish
Insulin replacement therapy is mostly used by patients with type 2 diabetes who become insulin deficient and have failed other therapeutic options. They comprise about a quarter of those with diabetes, endures the majority of the complications and consumes the majority of the resources. Adequate insulin replacement therapy can prevent complications and reduce expenses, as long as therapy goals are achieved and maintained. Sadly, these therapy goals are seldom achieved and outcomes have not improved for decades despite advances in pharmacotherapy and technology...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29662686/patterns-of-physical-activity-in-sedentary-older-individuals-with-type-2-diabetes
#13
Pearl G Lee, Jinkyung Ha, Caroline S Blaum, Kimberlee Gretebeck, Neil B Alexander
Background: The Community Healthy Activities Model Program for Seniors (CHAMPS) survey, summarized into weekly caloric expenditures, is a common physical activity (PA) assessment tool among older adults. Specific types of PA reported in the CHAMPS have not been systematically analyzed. We applied latent class analysis to identify the patterns of PA among sedentary older adults with diabetes reported in the CHAMPS survey. Methods: Latent class models of PA were identified using the CHAMPS survey data reported by 115 individuals aged ≥60 years with type 2 diabetes whom volunteered for a clinical study of PA...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29610677/potential-association-of-lmna-associated-generalized-lipodystrophy-with-juvenile-dermatomyositis
#14
Melis Sahinoz, Shafaq Khairi, Ashley Cuttitta, Graham F Brady, Amit Rupani, Rasimcan Meral, Marwan K Tayeh, Peedikayil Thomas, Meredith Riebschleger, Sandra Camelo-Piragua, Jeffrey W Innis, M Bishr Omary, Daniel E Michele, Elif A Oral
Background: Juvenile dermatomyositis (JDM) is an auto-immune muscle disease which presents with skin manifestations and muscle weakness. At least 10% of the patients with JDM present with acquired lipodystrophy. Laminopathies are caused by mutations in the lamin genes and cover a wide spectrum of diseases including muscular dystrophies and lipodystrophy. The p.T10I LMNA variant is associated with a phenotype of generalized lipodystrophy that has also been called atypical progeroid syndrome...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29541481/determinants-of-hospitalization-in-chinese-patients-with-type-2-diabetes-receiving-a-peer-support-intervention-and-jade-integrated-care-the-pearl-randomised-controlled-trial
#15
Roseanne O Yeung, Jing-Heng Cai, Yuying Zhang, Andrea O Luk, Jun-Hao Pan, Junmei Yin, Risa Ozaki, Alice P S Kong, Ronald Ma, Wing-Yee So, Chiu Chi Tsang, K P Lau, Edwin Fisher, Williams Goggins, Brian Oldenburg, Julianna Chan
Background: In a randomized controlled trial of 628 Chinese patients with type 2 diabetes receiving multidisciplinary care in the Joint Asia Diabetes Evaluation (JADE) Progam, 372 were randomized to receive additional telephone-based peer support (Peer Empowerment And Remote communication Linked by information technology, PEARL) intervention. After 12 months, all-cause hospitalization was reduced by half in the PEARL group especially in those with high Depression Anxiety and Stress Scale (DASS) scores...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29507751/graves-hyperthyroidism-in-pregnancy-a-clinical-review
#16
REVIEW
Caroline T Nguyen, Elizabeth B Sasso, Lorayne Barton, Jorge H Mestman
Background: Graves' hyperthyroidism affects 0.2% of pregnant women. Establishing the correct diagnosis and effectively managing Graves' hyperthyroidism in pregnancy remains a challenge for physicians. Main: The goal of this paper is to review the diagnosis and management of Graves' hyperthyroidism in pregnancy. The paper will discuss preconception counseling, etiologies of hyperthyroidism, thyroid function testing, pregnancy-related complications, maternal management, including thyroid storm, anti-thyroid drugs and the complications for mother and fetus, fetal and neonatal thyroid function, neonatal management, and maternal post-partum management...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29445518/why-do-endocrine-profiles-in-elite-athletes-differ-between-sports
#17
Peter H Sönksen, Richard I G Holt, Walailuck Böhning, Nishan Guha, David A Cowan, Christiaan Bartlett, Dankmar Böhning
Background: Endocrine profiles have been measured on blood samples obtained immediately post-competition from 693 elite athletes from 15 Olympic Sports competing at National or International level; four were subsequently excluded leaving 689 for the current analysis. Methods: Body composition was measured by bioimpedance in a sub-set of 234 (146 men and 88 women) and from these data a regression model was constructed that enabled 'estimated' lean body mass and fat mass to be calculated on all athletes...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29340167/subcutaneous-glucagon-infusion-and-continuous-glucose-monitoring-enable-effective-management-of-hypoglycemia-in-a-patient-with-igf-2-producing-hemangiopericytoma
#18
Eric D Buras, Emily Weatherup, Jennifer Wyckoff
Background: Ectopic insulin-like growth factor (IGF)-2 production is a rare complication of an array of epithelial and mesenchymal tumors, and can clinically manifest as life-threatening hypoglycemia. Case presentation: A 49-year-old woman with 13-year history of metastatic hemangiopericytoma, previously treated with multiple rounds of chemotherapy and palliative radiation, presented to the emergency department after a hypoglycemic seizure. On arrival, glucose was 18 mg/dL (1...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29318033/the-association-of-depression-and-diabetes-across-methods-measures-and-study-contexts
#19
Jaimie C Hunter, Brenda M DeVellis, Joanne M Jordan, M Sue Kirkman, Laura A Linnan, Christine Rini, Edwin B Fisher
Background: Empirical research has revealed a positive relationship between type 2 diabetes mellitus and depression, but questions remain regarding timing of depression measurement, types of instruments used to measure depression, and whether "depression" is defined as clinical depression or depressive symptoms. The present study sought to establish the robustness of the depression-diabetes relationship across depression definition, severity of depressive symptoms, recent depression, and lifetime depression in a nationally representative dataset and a large rural dataset...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29299335/perspectives-on-the-impact-of-painful-diabetic-peripheral-neuropathy-in-a-multicultural-population
#20
Martin Eichholz, Andrea H Alexander, Joseph C Cappelleri, Patrick Hlavacek, Bruce Parsons, Alesia Sadosky, Michael M Tuchman
Background: Since few studies have characterized painful diabetic peripheral neuropathy (pDPN) symptoms in multicultural populations, this study fielded a survey to better understand pDPN and its impact in African-American, Caucasian, and Hispanic populations. Methods: Kelton fielded a survey by phone or Internet, in English or Spanish, among adults with pDPN symptoms in the United States between August and October 2015; African-Americans and Hispanics were oversampled to achieve at least 500 subjects for each group...
2017: Clinical Diabetes and Endocrinology
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