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Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

Pei Feng, Ping Wu, Chengde Gao, Youwen Yang, Wang Guo, Wenjing Yang, Cijun Shuai
Polyetheretherketone (PEEK)/β-tricalcium phosphate (β-TCP) scaffolds are expected to be able to combine the excellent mechanical strength of PEEK and the good bioactivity and biodegradability of β-TCP. While PEEK acts as a closed membrane in which β-TCP is completely wrapped after the melting/solidifying processing, the PEEK membrane degrades very little, hence the scaffolds cannot display bioactivity and biodegradability. The strategy reported here is to blend a biodegradable polymer with PEEK and β-TCP to fabricate multi-material scaffolds via selective laser sintering (SLS)...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Yi Zhang, Feng Wang, Mingqiang Li, Zhiqiang Yu, Ruogu Qi, Jianxun Ding, Zhiyu Zhang, Xuesi Chen
[This corrects the article DOI: 10.1002/advs.201700821.].
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Zheng-Ze Pan, Wei Lv, Yan-Bing He, Yan Zhao, Guangmin Zhou, Liubing Dong, Shuzhang Niu, Chen Zhang, Ruiyang Lyu, Cong Wang, Huifa Shi, Wenjie Zhang, Feiyu Kang, Hirotomo Nishihara, Quan-Hong Yang
Lithium-sulfur (Li-S) batteries are considered as one of the most promising energy storage systems for next-generation electric vehicles because of their high-energy density. However, the poor cyclic stability, especially at a high sulfur loading, is the major obstacles retarding their practical use. Inspired by the nacre structure of an abalone, a similar configuration consisting of layered carbon nanotube (CNT) matrix and compactly embedded sulfur is designed as the cathode for Li-S batteries, which are realized by a well-designed unidirectional freeze-drying approach...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Huan-Huan Gao, Yanna Sun, Xiangjian Wan, Xin Ke, Huanran Feng, Bin Kan, Yanbo Wang, Yamin Zhang, Chenxi Li, Yongsheng Chen
A new acceptor-donor-acceptor (A-D-A) type nonfullerene acceptor, 3TT-FIC , which has three fused thieno[3,2-b]thiophene as the central core and difluoro substituted indanone as the end groups, is designed and synthesized. 3TT-FIC exhibits broad and strong absorption with extended onset absorption to 995 nm and a low optical bandgap of 1.25 eV. The binary device based on 3TT-FIC and the polymer PTB7-Th exhibits a power conversion efficiency (PCE) of 12.21% with a high short circuit current density (    J sc ) of 25...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Dongdong Wang, Huihui Wu, Jiajia Zhou, Pengping Xu, Changlai Wang, Ruohong Shi, Haibao Wang, Hui Wang, Zhen Guo, Qianwang Chen
Herein, a simple one-pot way is designed to prepare a type of multifunctional metal-organic framework (MOF)-based hybrid nanogels by in situ hybridization of dopamine monomer in the skeleton of MnCo. The resultant hybrid nanoparticles (named as MCP) show enhanced photothermal conversion efficiency in comparison with pure polydopamine or MnCo nanoparticles (NPs) synthesized under a similar method and, therefore, show great potential for photothermal therapy (PTT) in vivo. The MCP NPs are expected to possess T 1 positive magnetic resonance imaging ability due to the high-spin Mn-N6 ( S = 5/2) in the skeleton of MnCo...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Rongrong Tian, Hua Zhang, Hongda Chen, Guifeng Liu, Zhenxin Wang
There is a high desire for novel targets/biomarkers to diagnose and treat colorectal cancer (CRC). Here, an approach starting from a polyacrylamide hydrogel-based lectin microarray is presented to screen the high expression of glycans on the CRC cell surface and to identify new lectin biomarkers for CRC. Three common CRC cell lines (SW480, SW620, and HCT116) and one normal colon cell line (NCM460) are profiled on the microarray with 27 lectins. The experimental results reveal that CRC cells highly express the glycans with d-galactose, d-glucose, and/or sialic acid residues, and Uelx Europaeus Agglutinin-I (UEA-I) exhibits reasonable specificity with SW480 cells...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Yonghui Lee, Seunghwan Lee, Gabseok Seo, Sanghyun Paek, Kyung Taek Cho, Aron J Huckaba, Marco Calizzi, Dong-Won Choi, Jin-Seong Park, Dongwook Lee, Hyo Joong Lee, Abdullah M Asiri, Mohammad Khaja Nazeeruddin
Planar perovskite solar cells using low-temperature atomic layer deposition (ALD) of the SnO2 electron transporting layer (ETL), with excellent electron extraction and hole-blocking ability, offer significant advantages compared with high-temperature deposition methods. The optical, chemical, and electrical properties of the ALD SnO2 layer and its influence on the device performance are investigated. It is found that surface passivation of SnO2 is essential to reduce charge recombination at the perovskite and ETL interface and show that the fabricated planar perovskite solar cells exhibit high reproducibility, stability, and power conversion efficiency of 20%...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Xing Wu, Kaihao Yu, Dongkyu Cha, Michel Bosman, Nagarajan Raghavan, Xixiang Zhang, Kun Li, Qi Liu, Litao Sun, Kinleong Pey
Higher memory density and faster computational performance of resistive switching cells require reliable array-accessible architecture. However, selecting a designated cell within a crossbar array without interference from sneak path currents through neighboring cells is a general problem. Here, a highly doped n++ Si as the bottom electrode with Ni-electrode/HfO x /SiO2 asymmetric self-rectifying resistive switching device is fabricated. The interfacial defects in the HfO x /SiO2 junction and n++ Si substrate result in the reproducible rectifying behavior...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Peng Ge, Hongshuai Hou, Xiaoyu Cao, Sijie Li, Ganggang Zhao, Tianxiao Guo, Chao Wang, Xiaobo Ji
Different dimensions of carbon materials with various features have captured numerous interests due to their applications on the tremendous fields. Restricted by the raw materials and devices, the controlling of their morphology is a major challenge. Utilizing the catalytic features of the intermediates from the low-cost salts and polymerization of 0D carbon quantum dots (CQDs), 0D CQDs are expected to self-assemble into 1/2/3D carbon structures with the assistance of temperature-induced intermediates (e.g...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Bin Zheng, Rongrong Zhu, Liqiao Jing, Yihao Yang, Lian Shen, Huaping Wang, Zuojia Wang, Xianmin Zhang, Xu Liu, Erping Li, Hongsheng Chen
The concept of an invisibility cloak is a fixture of science fiction, fantasy, and the collective imagination. However, a real device that can hide an object from sight in visible light from absolutely any viewpoint would be extremely challenging to build. The main obstacle to creating such a cloak is the coupling of the electromagnetic components of light, which would necessitate the use of complex materials with specific permittivity and permeability tensors. Previous cloaking solutions have involved circumventing this obstacle by functioning either in static (or quasistatic) fields where these electromagnetic components are uncoupled or in diffusive light scattering media where complex materials are not required...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Manjae Gil, Seongjun Moon, Jaewon Yoon, Sahar Rhamani, Jae-Won Shin, Kyung Jin Lee, Joerg Lahann
Anisotropically compartmentalized microparticles have attracted increasing interest in areas ranging from sensing, drug delivery, and catalysis to microactuators. Herein, a facile method is reported for the preparation of helically decorated microbuilding blocks, using a modified electrohydrodynamic cojetting method. Bicompartmental microfibers are twisted in situ, during electrojetting, resulting in helical microfibers. Subsequent cryosectioning of aligned fiber bundles provides access to helically decorated microcylinders...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Yonghyun Lee, Soyoung Lee, Sangyong Jon
The tumor microenvironment (TME) plays a crucial role in tumorigenesis and cancer cell metastasis. Accordingly, a drug-delivery system (DDS) that is capable of targeting tumor and releasing drugs in response to TME-associated stimuli should lead to potent antitumor efficacy. Here, a cancer targeting, reactive oxygen species (ROS)-responsive drug delivery vehicle as an example of a TME-targeting DDS is reported. Tumor targeting is achieved using biotin as a ligand for "biotin transporter"-overexpressing malignant tumors, and bilirubin-based nanoparticles (BRNPs) are used as a drug-delivery carrier that enables ROS-responsive drug release...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Hui Guo, Faping Li, Weiguo Xu, Jinjin Chen, Yuchuan Hou, Chunxi Wang, Jianxun Ding, Xuesi Chen
Initially, chemotherapy is effective for treatment of bladder cancer after transurethral resection of the bladder. However, certain patients progressively become unresponsive after multiple treatment cycles, which results from the rapid and almost complete excretion of clinically used formulations of antineoplastic agents with urinary voiding. Improving the mucoadhesiveness and penetrability of chemotherapeutic drugs are key factors in treatment of advanced bladder cancer. Here, a smart disulfide-crosslinked polypeptide nanogel of poly(l-lysine)-poly(l-phenylalanine- co -l-cystine) (PLL-P(LP- co -LC)) is developed to deliver 10-hydroxycamptothecin (HCPT) for treatment of orthotopic bladder cancer...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Xudong Ji, Pengcheng Zhou, Ling Zhong, Aimin Xu, Anderson C O Tsang, Paddy K L Chan
Organic field-effect transistors (OFETs)-based sensors have a great potential to be integrated with the next generation smart surgical tools for monitoring different real-time signals during surgery. However, allowing ultraflexible OFETs to have compatibility with standard medical sterilization procedures remains challenging. A novel capsule-like OFET structure is demonstrated by utilizing the fluoropolymer CYTOP to serve both encapsulation and peeling-off enhancement purposes. By adapting a thermally stable organic semiconductor, 2,10-diphenylbis[1]benzothieno[2,3-d;2',3'-d']naphtho[2,3-b;6,7-b']dithiophene (DPh-BBTNDT), these devices show excellent stability in their electrical performance after sterilizing under boiling water and 100 °C-saturated steam for 30 min...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Tao Yang, Alexander N Zelikin, Rona Chandrawati
Nitric oxide (NO) is a highly potent radical with a wide spectrum of physiological activities. Depending on the concentration, it can enhance endothelial cell proliferation in a growth factor-free medium, mediate angiogenesis, accelerate wound healing, but may also lead to tumor progression or induce inflammation. Due to its multifaceted role, NO must be administered at a right dose and at the specific site. Many efforts have focused on developing NO-releasing biomaterials; however, NO short half-life in human tissues only allows this molecule to diffuse over short distances, and significant challenges remain before the full potential of NO can be realized...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Hang Kuen Lau, Alexandra Paul, Ishnoor Sidhu, Linqing Li, Chandran R Sabanayagam, Sapun H Parekh, Kristi L Kiick
Heterogeneous hydrogels with desired matrix complexity are studied for a variety of biomimetic materials. Despite the range of such microstructured materials described, few methods permit independent control over microstructure and microscale mechanics by precisely controlled, single-step processing methods. Here, a phototriggered crosslinking methodology that traps microstructures in liquid-liquid phase-separated solutions of a highly elastomeric resilin-like polypeptide (RLP) and poly(ethylene glycol) (PEG) is reported...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Kai Liu, Xiaokang Ren, Jianxuan Sun, Qianli Zou, Xuehai Yan
The emergence of light-energy-utilizing metabolism is likely to be a critical milestone in prebiotic chemistry and the origin of life. However, how the primitive pigment is spontaneously generated still remains unknown. Herein, a primitive pigment model based on adaptive self-organization of amino acids (Cystine, Cys) and metal ions (zinc ion, Zn2+ ) followed by chemical evolution under hydrothermal conditions is developed. The resulting hybrid microspheres are composed of radially aligned cystine/zinc (Cys/Zn) assembly decorated with carbonate-doped zinc sulfide (C-ZnS) nanocrystals...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Junjie Li, Jiangchun Chen, Hua Wang, Na Chen, Zhongchang Wang, Lin Guo, Francis Leonard Deepak
Understanding classical and nonclassical mechanisms of crystal nucleation and growth at the atomic scale is of great interest to scientists in many disciplines. However, fulfilling direct atomic-scale observation still poses a significant challenge. Here, by taking a thin amorphous bismuth (Bi) metal nanosheet as a model system, direct atomic resolution of the crystal nucleation and growth initiated from an amorphous state of Bi metal under electron beam inside an aberration-corrected transmission electron microscope is provided...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Paloma L Dos Santos, Jonathan S Ward, Daniel G Congrave, Andrei S Batsanov, Julien Eng, Jessica E Stacey, Thomas J Penfold, Andrew P Monkman, Martin R Bryce
By inverting the common structural motif of thermally activated delayed fluorescence materials to a rigid donor core and multiple peripheral acceptors, reverse intersystem crossing (rISC) rates are demonstrated in an organic material that enables utilization of triplet excited states at faster rates than Ir-based phosphorescent materials. A combination of the inverted structure and multiple donor-acceptor interactions yields up to 30 vibronically coupled singlet and triplet states within 0.2 eV that are involved in rISC...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Jingyi Ma, Xiaotian Guo, Yan Yan, Huaiguo Xue, Huan Pang
Iron oxides (FeO x ), such as Fe2 O3 and Fe3 O4 materials, have attracted much attention because of their rich abundance, low cost, and environmental friendliness. However, FeO x , which is similar to most transition metal oxides, possesses a poor rate capability and cycling life. Thus, FeO x -based materials consisting of FeO x , carbon, and metal-based materials have been widely explored. This article mainly discusses FeO x -based materials (Fe2 O3 and Fe3 O4 ) for electrochemical energy storage applications, including supercapacitors and rechargeable batteries (e...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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