journal
https://read.qxmd.com/read/38050373/does-hispanic-ethnicity-play-a-role-in-outcomes-for-diverticular-surgery-in-the-usa
#21
JOURNAL ARTICLE
Jesse K Kelley, Kathrine Kelly, Charles Reed, Nathan Winkler, Jessica Parker, James Ogilvie
OBJECTIVE: The aim of this study is to investigate whether origins of ethnicity affect the outcomes of surgery for diverticulitis in the USA. DESIGN: The American College of Surgeons National Surgical Quality Improvement Programme database from 2008 to 2017 was used to identify patients undergoing colectomy for diverticulitis. Patient demographics, comorbidities, procedural details and outcomes were captured and compared by ethnicity status. RESULTS: A total of 375 311 surgeries for diverticulitis were included in the final analysis...
December 2, 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/38030407/evaluating-clinical-outcomes-and-prognosis-in-patients-with-cirrhosis-and-portal-hypertension-a-retrospective-observational-cohort-study
#22
JOURNAL ARTICLE
Nerissa Hoi Ching Lee, Steven J Kiddle, Shardul Chandankhede, Shubh Agrawal, Daniel M Bean, Phillip R Hunt, Victoria E R Parker, Peter J Greasley, Philip Ambery
OBJECTIVE: Cirrhosis describes the end-stage of chronic liver disease. Irreversible changes in the liver cause portal hypertension, which can progress to serious complications and death. Only a few studies with small sample sizes have investigated the prognosis of cirrhosis with portal hypertension. We used electronic healthcare records to examine liver-related outcomes in patients with diagnosed/suspected portal hypertension. DESIGN: This retrospective observational cohort study used secondary health data between 1 January 2017 and 3 December 2020 from the TriNetX Network, a federated electronic healthcare records platform...
November 29, 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/38007223/interval-colorectal-cancers-after-negative-faecal-immunochemical-test-in-the-new-zealand-bowel-screening-pilot
#23
JOURNAL ARTICLE
Kai Sheng Saw, Kerry Sexton, Paul Frankish, Mike Hulme-Moir, Ian Bissett, Susan Parry
OBJECTIVE: Evaluate the diagnostic performance of faecal immunochemical test (FIT), identify risk factors for FIT-interval colorectal cancers (FIT-IC) and describe long-term outcomes of participants with colorectal cancers (CRC) in the New Zealand Bowel Screening Pilot (BSP). DESIGN: From 2012 to 2017, the BSP offered eligible individuals, aged 50-74 years, biennial screening using a quantitative FIT with positivity threshold of 15 µg haemoglobin (Hb)/g faeces...
November 24, 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37996121/cardiac-and-intramuscular-adaptations-following-short-term-exercise-prehabilitation-in-unfit-patients-scheduled-to-undergo-hepatic-or-pancreatic-surgery-study-protocol-of-a-multinuclear-mri-study
#24
JOURNAL ARTICLE
Allard G Wijma, Heleen Driessens, Jeroen A L Jeneson, Maryska L G Janssen-Heijnen, Tineke P Willems, Joost M Klaase, Bart C Bongers
INTRODUCTION: Short-term exercise prehabilitation programmes have demonstrated promising results in improving aerobic capacity of unfit patients prior to major abdominal surgery. However, little is known about the cardiac and skeletal muscle adaptations explaining the improvement in aerobic capacity following short-term exercise prehabilitation. METHODS AND ANALYSIS: In this single-centre study with a pretest-post-test design, 12 unfit patients with a preoperative oxygen uptake (VO2 ) at the ventilatory anaerobic threshold ≤13 mL/kg/min and/or VO2 at peak exercise ≤18 mL/kg/min, who are scheduled to undergo hepatopancreatobiliary surgery at the University Medical Center Groningen (UMCG), the Netherlands, will be recruited...
November 23, 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37996120/practical-multidisciplinary-framework-for-the-assessment-and-management-of-patients-with-unexplained-chronic-aerodigestive-symptoms
#25
REVIEW
Nathan Quigley, Sandeep G Mistry, Dipesh H Vasant, Sarju Vasani
OBJECTIVE: Patients experiencing unexplained chronic throat symptoms (UCTS) are frequently referred to gastroenterology and otolaryngology outpatient departments for investigation. Often despite extensive investigations, an identifiable structural abnormality to account for the symptoms is not found. The objective of this article is to provide a concise appraisal of the evidence-base for current approaches to the assessment and management of UCTS, their clinical outcomes, and related healthcare utilisation...
November 23, 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37993269/elobixibat-improves-rectal-sensation-in-patients-with-chronic-constipation-aged-%C3%A2-60-years-a-randomised-placebo-controlled-study
#26
RANDOMIZED CONTROLLED TRIAL
Noriaki Manabe, Minami Umeyama, Sonoko Ishizaki, Takumi Ota, Shinji Kuratani, Ryo Katsumata, Minoru Fujita, Ken Haruma, Michael Camilleri
OBJECTIVE: High rectal sensory thresholds (RSTs) are associated with chronic constipation (CC), especially in older patients. Bile acids (BAs) affect the RSTs of healthy individuals. Here, we aimed to investigate the effects of the BA transporter inhibitor elobixibat in patients with CC aged ≥60 years. DESIGN: We prospectively compared the RSTs of 17 patients with CC aged ≥60 years with those of 9 healthy individuals of the same age range. We next performed a prospective, randomised, parallel-group, double-blind, placebo-controlled clinical trial of 17 patients with CC who administered elobixibat or placebo daily for 1 week...
November 22, 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37989352/impact-of-the-covid-19-pandemic-on-patients-with-hepatocellular-carcinoma-in-the-west-of-scotland-a-cohort-study
#27
JOURNAL ARTICLE
Alistair Stewart McLaren, Johannes A Spoor, Douglas Cartwright, Gregory Naylor, Stephen Barclay, Matthew Priest, Srikanth Puttagunta, Kirsty Armstrong, Stuart Ballantyne, Adrian Stanley, Thomas R Jeffry Evans
OBJECTIVE: The COVID-19 pandemic had an undoubted impact on the provision of elective and emergency cancer care, including the diagnosis and management of patients with hepatocellular carcinoma (HCC). Our aim was to determine the effects of the COVID-19 pandemic on patients with HCC in the West of Scotland. DESIGN: This was a retrospective audit of a prospectively collated database of patients presented to the West of Scotland Multidisciplinary Team (MDT) between April and October 2020 (during the pandemic), comparing baseline demographics, characteristics of disease at presentation, diagnostic workup, treatment and outcomes with patients from April to October 2019 (pre pandemic)...
November 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37963649/covid-19-severity-is-associated-with-the-risk-of-gastrointestinal-bleeding
#28
JOURNAL ARTICLE
Shuji Hibiya, Takashi Fujii, Toshimitsu Fujii, Shinji Suzuki, Mayumi Kondo, Shinya Ooka, Yohei Furumoto, Seishin Azuma, Kei Tanaka, Hitoshi Kurata, Shohei Tanaka, Masayuki Kurosaki, Kazuyoshi Nagayama, Fumihiko Kusano, Yasuhiro Iizuka, Takahiro Kawamura, Hidekazu Ikemiyagi, Shinya Sakita, Tsunehito Yauchi, Hideki Watanabe, Ami Kawamoto, Yusuke Matsuyama, Kazuo Ohtsuka, Ryuichi Okamoto
OBJECTIVE: The association between the severity of COVID-19 and gastrointestinal (GI) bleeding is unknown. This study aimed to determine whether the severity of COVID-19 is a risk factor for GI bleeding. DESIGN: A multicentre, retrospective cohort study was conducted on hospitalised patients with COVID-19 between January 2020 and December 2021. The severity of COVID-19 was classified according to the National Institute of Health severity classification. The primary outcome was the occurrence of GI bleeding during hospitalisation...
November 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37880157/time-to-treat-the-climate-and-nature-crisis-as-one-indivisible-global-health-emergency
#29
EDITORIAL
Chris Zielinski
No abstract text is available yet for this article.
October 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37832963/polygenic-risk-score-predicts-risk-of-primary-sclerosing-cholangitis-in-inflammatory-bowel-disease
#30
JOURNAL ARTICLE
Ming-Hsi Wang, Jessica J Friton, Laura E Raffals, Jonathan A Leighton, Shabana F Pasha, Michael F Picco, Kelly Monroe, Billy D Nix, Rodney D Newberry, William A Faubion
BACKGROUND: Forty distinct primary sclerosing cholangitis (PSC) genomic loci have been identified through multiancestry meta-analyses. The polygenic risk score (PRS) could serve as a promising tool to discover unique disease behaviour, like PSC, underlying inflammatory bowel disease (IBD). AIM: To test whether PRS indicates PSC risk in patients with IBD. MATERIALS AND METHODS: Mayo Clinic and Washington University at St Louis IBD cohorts were used to test our hypothesis...
October 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37797967/quality-standards-for-the-management-of-alcohol-related-liver-disease-consensus-recommendations-from-the-british-association-for-the-study-of-the-liver-and-british-society-of-gastroenterology-arld-special-interest-group
#31
JOURNAL ARTICLE
Richard Parker, Michael Allison, Seonaid Anderson, Richard Aspinall, Sara Bardell, Vikram Bains, Ryan Buchanan, Lynsey Corless, Ian Davidson, Pauline Dundas, Jeff Fernandez, Ewan Forrest, Erica Forster, Dennis Freshwater, Ruth Gailer, Robert Goldin, Vanessa Hebditch, Steve Hood, Arron Jones, Victoria Lavers, Deborah Lindsay, James Maurice, Joanne McDonagh, Sarah Morgan, Tania Nurun, Christopher Oldroyd, Elizabeth Oxley, Sally Pannifex, Graham Parsons, Thomas Phillips, Nicole Rainford, Neil Rajoriya, Paul Richardson, J Ryan, Joanne Sayer, Mandy Smith, Ankur Srivastava, Emma Stennett, Jennifer Towey, Roya Vaziri, Ian Webzell, Andrew Wellstead, Ashwin Dhanda, Steven Masson
OBJECTIVE: Alcohol-related liver disease (ALD) is the most common cause of liver-related ill health and liver-related deaths in the UK, and deaths from ALD have doubled in the last decade. The management of ALD requires treatment of both liver disease and alcohol use; this necessitates effective and constructive multidisciplinary working. To support this, we have developed quality standard recommendations for the management of ALD, based on evidence and consensus expert opinion, with the aim of improving patient care...
October 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37699732/implementation-of-bsg-acpgbi-phe-polypectomy-surveillance-guidelines-safely-reduces-the-burden-of-surveillance-in-a-screening-cohort-a-virtual-model-study
#32
JOURNAL ARTICLE
Roisin Stack, Jayne Doherty, Neil O'Moráin, Blathnaid Nolan, Juliette Sheridan, Garret Cullen, Hugh Mulcahy, Maire Buckley, Gareth Horgan, Mohamed Hamed, Edel McDermott, Glen Doherty
OBJECTIVE: To evaluate the impact of British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England (BSG/ACPGBI/PHE) 2019 polypectomy surveillance guidelines within a national faecal immunochemical test-based bowel cancer screening (BS) cohort on surveillance activity and detection of pathology by retrospective virtual application. DESIGN: A retrospective review of BS colonoscopies performed in 2015-2016 with 5 years prospective follow-up in single institution...
September 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37652551/evaluation-of-vitamin-b-6-supplementation-in-wilson-s-disease-patients-treated-with-d-penicillamine
#33
JOURNAL ARTICLE
Justin Mbala, Abdelouahed Belmalih, Olivier Guillaud, Alain Lachaux, Eduardo Couchonnal Bedoya
INTRODUCTION: Wilson's disease (WD) is a copper metabolism disorder characterised by a progressive accumulation of this metal mainly in the liver and the brain. Treatment is based on the removal of copper operated by the chelators, among which, D-penicillamine (DP) is prescribed as a first-line treatment in most situations. There is some evidence in linking the use of DP with a risk of vitamin B6 ; therefore, vitamin supplementation is sometimes recommended, although non-consensually...
August 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37597875/evaluation-of-the-efficacy-and-safety-of-an-innovative-flavonoid-lotion-in-patients-with-haemorrhoid-a-randomised-clinical-trial
#34
RANDOMIZED CONTROLLED TRIAL
Sara Razdar, Yunes Panahi, Ramtin Mohammadi, Leila Khedmat, Hossein Khedmat
OBJECTIVE: Haemorrhoids are one of the most common gastrointestinal and anal diseases. In olive oil and honey propolis, flavonoids have beneficial effects on improving vascular function and decreasing vascular resistance. In this study, we aimed to produce a combination of these two substances in the form of lotions and assess their healing and side effects in comparison with routine treatment, anti-haemorrhoid ointment (containing hydrocortisone and lidocaine). DESIGN: In this randomised clinical trial study, 86 patients with grade 2 or more haemorrhoid degrees, diagnosed by colonoscopy, were divided into two groups, the case (n=44) and control (n=42)...
August 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37567730/vascular-pathology-in-patients-with-alveolar-echinococcosis-framework-for-assessment-and-clinical-management-a-retrospective-case-series
#35
JOURNAL ARTICLE
Paula Gieser, Uta Merle, Thomas Junghanss, Tim F Weber, Marija Stojković
OBJECTIVE: Alveolar echinococcosis (AE) is a parasitic liver disease with infiltrative growth similar to solid organ malignancies. Major vascular damage is frequent and often remains untreated until catastrophic events precipitate. Detailed clinical and radiological assessment is required to guide individualised treatment decisions. Standardised radiological reporting templates of malignancies with profiles resembling AE are candidates for adaptation. Our objectives are to describe vascular pathology in AE and establish a framework for structured evaluation as the basis for treatment decisions and monitoring...
August 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37562856/cost-effectiveness-analysis-of-antibiotic-prophylaxis-versus-no-antibiotic-prophylaxis-for-acute-cholecystectomy
#36
RANDOMIZED CONTROLLED TRIAL
Maya Satheeskaran, Aminah Hussan, Ailin Anto, Laure de Preux
OBJECTIVE: For acute cholecystitis, the treatment of choice is laparoscopic cholecystectomy. In mild-to-moderate cases, the use of antibiotic prophylaxis for the prevention of postoperative infectious complications (POICs) lacks evidence regarding its cost-effectiveness when compared with no prophylaxis. In the context of rising antimicrobial resistance, there is a clear rationale for a cost-effectiveness analysis (CEA) to determine the most efficient use of National Health Service resources and antibiotic routine usage...
August 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37562855/technical-and-clinical-outcomes-following-eus-guided-thrombin-injection-and-coil-implantation-for-parastomal-varices
#37
JOURNAL ARTICLE
Andrew Todd, Chander Shekhar, Joanne O'Rourke, Colm Forde, Arvind Pallan, Sharan Suresh Wadhwani, Dhiraj Tripathi, Brinder Singh Mahon
BACKGROUND AND AIMS: Bleeding from parastomal varices causes significant morbidity and mortality. Treatment options are limited, particularly in high-risk patients with significant underlying liver disease and other comorbidities. The use of EUS-guided embolisation coils combined with thrombin injection in gastric varices has been shown to be safe and effective. Our institution has applied the same technique to the treatment of parastomal varices. METHODS: A retrospective review was performed of 37 procedures on 24 patients to assess efficacy and safety of EUS-guided injection of thrombin, with or without embolisation coils for treatment of bleeding parastomal varices...
August 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37524505/identifying-the-need-for-a-uk-colorectal-cancer-screening-programme-for-patients-with-cystic-fibrosis-cf-10-year-retrospective-review-of-colonoscopy-and-colorectal-cancer-outcomes-at-a-single-cf-centre
#38
JOURNAL ARTICLE
Karuna Sapru, Peter Barry, Andrew Jones, John Walmsley, Javaid Iqbal, Dipesh H Vasant
OBJECTIVE: Patients with cystic fibrosis (pwCF) have a high incidence of early colorectal cancer (CRC). In the absence of a UK CRC screening programme for pwCF, we evaluated the utility and outcomes of colonoscopy and CRC at a large UK CF centre. DESIGN: In a retrospective study of colonoscopy and CRC outcomes between 2010 and 2020 in pwCF aged≥30 years at a large CF centre, data were collected on colonoscopy indications and findings, polyp detection rates, bowel preparation regimens and outcomes, colonoscopy completion rates, and patient outcomes...
July 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37487649/prevalence-and-trends-of-transfusion-transmissible-infections-among-blood-donors-in-basra-iraq
#39
JOURNAL ARTICLE
Khairallah A S Mohammed, Maha M Hameed, Abdullah H Mousa, Amar T Saleh
BACKGROUND: Despite saving millions of lives through blood transfusion, transfusion-transmissible infections (TTIs) still threaten the lives of patients requiring blood transfusion. Hence, screening blood donors and studying the prevalence of TTIs among blood donors may display the burden of these diseases among our population. The aim of this study was to assess the seroprevalence rates of transfusion transmitted infections among blood donors in Basra, Iraq from 2019 to 2021 as groundwork for providing safe blood transfusion in Iraq...
July 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37433685/toll-like-receptor-5-tunes-hepatic-and-pancreatic-stellate-cells-activation
#40
JOURNAL ARTICLE
Pietro Di Fazio, Sophia Mielke, Isabell T Böhm, Malte Buchholz, Sami Matrood, Detlef Schuppan, Thaddeus Wissniowski
OBJECTIVE: Stellate cells are responsible for liver and pancreas fibrosis and strictly correlate with tumourigenesis. Although their activation is reversible, an exacerbated signalling triggers chronic fibrosis. Toll-like receptors (TLRs) modulate stellate cells transition. TLR5 transduces the signal deriving by the binding to bacterial flagellin from invading mobile bacteria. DESIGN: Human hepatic and pancreatic stellate cells were activated by the administration of transforming growth factor-beta (TGF-β)...
July 2023: BMJ Open Gastroenterology
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