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BMJ Open Gastroenterology

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https://www.readbyqxmd.com/read/29686881/mortality-in-coeliac-disease-a-population-based-cohort-study-from-a-single-centre-in-southern-derbyshire-uk
#1
Geoffrey K T Holmes, Andrew Muirhead
Objective: With the advent of screening tests, it was hypothesised that milder cases of coeliac disease coming to diagnosis might have reduced risk of mortality. An earlier publication did not support this view. We have re-examined this issue employing a larger number of patients followed for a further 8 years. Design: Patients with coeliac disease from Southern Derbyshire, UK, were followed prospectively from 1978 to 2014 and included those diagnosed by biopsy and serology...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29607054/non-alcoholic-steatofibrosis-nasf-can-independently-predict-mortality-in-patients-with-non-alcoholic-fatty-liver-disease-nafld
#2
Pegah Golabi, Maria Stepanova, Huong T Pham, Rebecca Cable, Nila Rafiq, Haley Bush, Trevor Gogoll, Zobair M Younossi
Background: Hepatic fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) independently predicts mortality. Given liver biopsy's invasive nature, non-invasive method to assess hepatic steatosis and fibrosis provides NAFLD risk stratification algorithm in clinical practice. NAFLD fibrosis score (NFS) is simple and non-invasive predictive model recommended by American Association for the Study of Liver Disease (AASLD) Guideline to identify patients with NAFLD with fibrosis risk...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29607053/rate-of-hepatocellular-carcinoma-surveillance-remains-low-for-a-large-real-life-cohort-of-patients-with-hepatitis-c-cirrhosis
#3
Sally Ann Tran, An Le, Changqing Zhao, Joseph Hoang, Lee Ann Yasukawa, Susan Weber, Linda Henry, Mindie H Nguyen
Background: In patients with chronic hepatitis C (CHC) cirrhosis, imaging for hepatocellular carcinoma (HCC) is recommended every 6 months to maximise eligibility for curative treatment. The aim was to determine the adherence rate and outcomes among patients with CHC cirrhosis and whether the adherence rate has improved over time. Methods: Retrospective cohort study of patients with CHC cirrhosis (n=2366) monitored for ≥1 year at Stanford University Medical Center between January 2001 and August 2015...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29607052/changing-nationwide-trends-in-endoscopic-medical-and-surgical-admissions-for-inflammatory-bowel-disease-2003-2013
#4
Ahmir Ahmad, Anthony A Laverty, Chris Alexakis, Tom Cowling, Sonia Saxena, Azeem Majeed, Richard C G Pollok
Background and study aims: In the last decade, there have been major advances in inflammatory bowel disease (IBD) management but their impact on hospital admissions requires evaluation. We aim to investigate nationwide trends in IBD surgical/medical elective and emergency admissions, including endoscopy and cytokine inhibitor infusions, between 2003 and 2013. Patients and methods: We used Hospital Episode Statistics and population data from the UK Office for National Statistics...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29527318/study-for-every-other-day-administration-of-vonoprazan-in-maintenance-treatment-of-erosive-gerd-study-protocol-for-a-multicentre-randomised-cross-over-study
#5
Mototsugu Kato, Noriko Ito, Mamiko Demura, Kimitoshi Kubo, Katsuhiro Mabe, Naohiko Harada
Introduction: The first drug selected for treatment of gastro-oesophageal reflux disease (GERD) and prevention of the recurrence is a proton pump inhibitor (PPI), but recently, a potassium-competitive acid blocker (P-CAB) was put on the market in Japan. Its onset of effect is faster than PPI, and it takes more than 2 days to recover acid secretion after the withdrawal period. Therefore, unlike PPI, the usefulness of every other day administration or discontinuous administration is expected...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29527317/implication-of-exercise-interventions-on-sleep-disturbance-in-patients-with-pancreatic-cancer-a-study-protocol-for-a-randomised-controlled-trial
#6
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Noriko Ishii, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction and purpose: Patients with pancreatic cancer (PC) have long been known to have high rates of depression. Depression in patients with PC can be linked to sleep disturbance. The American College of Sports Medicine notes that physical exercise is safe for most patients with cancer and physical inactivity should be avoided. However, clinical impacts of exercise interventions (EIs) on patients with PC have been poorly investigated. We aim to prospectively examine the effect of EIs on sleep disturbance in patients with PC using actigraphy, which is an objective measurement of motor activity and sleep...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29527316/outcome-of-tacrolimus-and-vedolizumab-after-corticosteroid-and-anti-tnf-failure-in-paediatric-severe-colitis
#7
Blaise Hamel, May Wu, Elizabeth O Hamel, Dorsey M Bass, K T Park
Background: Severe colitis flare from ulcerative colitis (UC) or Crohn's disease (CD) may be refractory to corticosteroids and antitumour necrosis factor (TNF) agents resulting in high colectomy rates. We aimed to describe the utility of tacrolimus to prevent colectomy during second-line vedolizumab initiation after corticosteroid and anti-TNF treatment failure in paediatric severe colitis. Methods: A retrospective cohort analysis was performed between 1 October 2014 and 31 October 2016 at a single tertiary care centre...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29527315/effect-of-exercise-therapy-on-sarcopenia-in-pancreatic-cancer-a-study-protocol-for-a-randomised-controlled-trial
#8
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Noriko Ishii, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction and purpose: Sarcopenia is defined as a decrease in muscle mass and muscle strength, and it has been demonstrated to be an adverse predictor in numerous types of cancers. Exercise therapy (ET) carries multiple health benefits in several diseases. Despite these clinical benefits, there are limited data available regarding patients with pancreatic cancer (PC) undergoing ET. We aim to prospectively examine the effect of ET on sarcopenia in patients with PC. Methods and analysis: All clinical stages of PC can be included...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29527314/clinical-impact-of-physical-exercise-on-sleep-disorder-as-assessed-by-actigram-in-patients-with-chronic-pancreatitis-a-study-protocol-for-a-randomised-controlled-trial
#9
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction: In most chronic pancreatitis (CP) cases, malabsorption, pain, and weight loss are the leading clinical symptoms, which significantly worsen the quality of life (QOL) and decreased QOL in patients with CP can cause sleep disorder. There is a growing body of evidence that recognises the favourable effects of physical exercise (PE), however, there are limited data currently available concerning patients with CP undergoing PE. Actigram is a device for gathering objective sleep/awake data in the natural sleeping surroundings over an extended time period...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29527313/a-randomised-controlled-trial-of-gemcitabine-hydrochloride-plus-s-1-combination-therapy-versus-gemcitabine-hydrochloride-therapy-alone-in-pancreatic-cancer-patients-aged-%C3%A2-75-years-a-study-protocol-for-an-open-label-randomised-feasibility-study
#10
Hiroshi Ishii, Natsumi Yamashita, Makoto Ueno, Shinichi Ohkawa, Akiko M Saito, Mitsugu Sekimoto
Introduction: In Japan, the age of patients with pancreatic cancer has increased. Combination chemotherapies such as 5-fluorouracil/leucovorin, oxaliplatin and irinotecan therapy and gemcitabine hydrochloride (GEM) +nab paclitaxel therapy have been developed as the standard treatments for young patients with advanced recurrent pancreatic cancer. However, both therapies produce toxicity and their administration is limited by the patients' age or performance status. The efficacy and safety data obtained in the GEST study-a large-scale randomised controlled study conducted in patients with pancreatic cancer in Japan-suggested that GEM +S-1 (GS) combination therapy is a promising candidate for those aged between 75 and 80 years...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29503733/clinicopathological-and-immunological-characteristics-and-outcome-of-concomitant-coeliac-disease-and-non-alcoholic-fatty-liver-disease-in-adults-a-large-prospective-longitudinal-study
#11
Sanaa Kamal, Khaled K Aldossari, Dhalia Ghoraba, Sara Mahmoud Abdelhakam, Amgad H Kamal, Mohamad Bedewi, Leila Nabegh, Khaled Bahnasy, Tamer Hafez
Objective: Concomitant non-alcoholic fatty liver disease (NAFLD) and coeliac disease (CD) have not been adequately studied. This study investigated the frequency of CD among NAFLD patients and the clinicopathological and immunological patterns and outcome of concomitant NAFLD and CD. Design: This prospective longitudinal study screened patients with NAFLD for CD (tissue transglutaminase antibodies (TTGA); anti-TTGA and antiendomysial antibodies (EMA)). Patients with concomitant NAFLD and CD and patients with either NAFLD or CD were enrolled and followed...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29379609/protocol-for-a-multicentred-randomised-controlled-trial-investigating-the-use-of-personalised-golimumab-dosing-tailored-to-inflammatory-load-in-ulcerative-colitis-the-goal-arc-study-glm-dose-optimisation-to-adequate-levels-to-achieve-response-in-colitis-led
#12
Juliette Sheridan, Carol Ann Coe, Peter Doran, Laurence Egan, Garret Cullen, David Kevans, Jan Leyden, Marie Galligan, Aoibhlinn O'Toole, Jane McCarthy, Glen Doherty
Introduction: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD), often leading to an impaired quality of life in affected patients. Current treatment modalities include antitumour necrosis factor (anti-TNF) monoclonal antibodies (mABs) including infliximab, adalimumab and golimumab (GLM). Several recent retrospective and prospective studies have demonstrated that fixed dosing schedules of anti-TNF agents often fails to consistently achieve adequate circulating therapeutic drug levels (DL) with consequent risk of immunogenicity treatment failure and potential risk of hospitalisation and colectomy in patients with UC...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29333278/clinical-influence-of-exercise-therapy-on-sarcopenia-in-patients-with-chronic-pancreatitis-a-study-protocol-for-a-randomised-controlled-trial
#13
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction and purpose: Chronic pancreatitis (CP) involves progressive inflammatory changes to the pancreas and can lead to permanent structural damage and impairment of both endocrine and exocrine functions. Current reports highlight a rise in the incidence and prevalence of CP. However, there is limited data currently available concerning patients with CP undergoing exercise therapy (ET). We aim to prospectively examine the influence of ET on sarcopenia in patients with CP. Methods and analysis: A detailed evaluation of the nutritional condition and the daily physical activities of each participant will be conducted prior to entering the study...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29333277/familial-risks-for-gallstones-in-the-population-of-sweden
#14
Kari Hemminki, Otto Hemminki, Asta Försti, Kristina Sundquist, Jan Sundquist, Xinjun Li
Objectives: Gallstone disease (cholelithiasis) has a familial component, but detailed data on the modification of familial risk are lacking. Using nationwide hospital and population records, we aimed to determine detailed familial risks for medically diagnosed gallstone disease. Design: Subjects were obtained from the Multigeneration Register, which contains family data on the Swedish population, and patients with gallstone disease were identified from the Hospital Discharge Register (1964-2015) and the Outpatient Register (2001-2015)...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29333276/neuropsychiatric-performance-and-treatment-of-hepatitis-c-with-direct-acting-antivirals-a-prospective-study
#15
Sofia Volpato, Sara Montagnese, Alberto Zanetto, Matteo Turco, Michele De Rui, Alberto Ferrarese, Piero Amodio, Giacomo Germani, Marco Senzolo, Martina Gambato, Francesco Paolo Russo, Patrizia Burra
Background: Since direct-acting antivirals (DAAs) have been approved for the treatment of hepatitis C virus (HCV) infection, a small series of patients with new-onset neuropsychiatric alterations have been referred to us. We therefore set out to study neuropsychiatric function in relation to DAAs prospectively. Methods: Ten patients with cirrhosis and 12 post-liver transplant (post-LT) patients were enrolled. All underwent wake electroencephalography (EEG) and a neuropsychological evaluation (paper and pencil battery, simple/choice reaction times, working memory task) at baseline, at the end of treatment with DAAs and after 6 months...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29333275/barriers-to-care-for-chronic-hepatitis-c-in-the-direct-acting-antiviral-era-a-single-centre-experience
#16
Peter Nguyen, Philip Vutien, Joseph Hoang, Sam Trinh, An Le, Lee Ann Yasukawa, Susan Weber, Linda Henry, Mindie H Nguyen
Background: Cure rates for chronic hepatitis C have improved dramatically with direct-acting antivirals (DAAs), but treatment barriers remain. We aimed to compare treatment initiation rates and barriers across both interferon-based and DAA-based eras. Methods: We conducted a retrospective cohort study of all patients with chronic hepatitis C seen at an academic hepatology clinic from 1999 to 2016. Patients were identified to have chronic hepatitis C by the International Classification of Diseases, Ninth Revision codes, and the diagnosis was validated by chart review...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29259793/effect-of-physical-exercise-on-sarcopaenia-in-patients-with-overt-hepatic-encephalopathy-a-study-protocol-for-a-randomised-controlled-trial
#17
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction: Limited data are currently available for patients with overt hepatic encephalopathy (OHE)) receiving physical exercise (PE). The aim of the current study is to prospectively examine the effect of PE on sarcopaenia in patients with OHE. Methods and analysis: At the time of patient recruitment, a precise assessment for nutritional status and daily physical activities will be performed in each subject. Study participants will be randomly assigned into two groups: (1) the PE group and (2) the control group...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29259792/pcr-detection-of-segmented-filamentous-bacteria-in-the-terminal-ileum-of-patients-with-ulcerative-colitis
#18
Alessia Finotti, Jessica Gasparello, Ilaria Lampronti, Lucia Carmela Cosenza, Giovanni Maconi, Vincenzo Matarese, Valentina Gentili, Dario Di Luca, Roberto Gambari, Michele Caselli
Objectives: Segmented filamentous bacteria (SFB) have been detected in a wide range of different animal. Recently, the presence of SFB-like bacteria was shown in biopsies of the terminal ileum and ileocecal valve of both patients with ulcerative colitis and control subjects. The aim of this study was to verify whether PCR methods could be used for the detection of SFB in biopsy of patients with ulcerative colitis and its relationships with the disease stage. Methods: PCR methods were used to identify SFB in biopsies from the terminal ileum of patients with ulcerative colitis, showing that this approach represents a useful tool for the detection of SFB presence and analysis of the bacterial load...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29259791/diagnostic-accuracy-of-high-resolution-mri-as-a-method-to-predict-potentially-safe-endoscopic-and-surgical-planes-in-patients-with-early-rectal-cancer
#19
Svetlana Balyasnikova, James Read, Andrew Wotherspoon, S Rasheed, Paris Tekkis, Diana Tait, David Cunningham, G Brown
Introduction: Early rectal cancer (ERC) assessment should include prediction of the potential excision plane to safely remove lesions with clear deep margins and feasibility of organ preservation. Method: MRI accuracy for differentiating ≤T1sm2 (partially preserved submucosa) or ≤T2 (partially preserved muscularis) versus >T2 tumours was compared with the gold standard of pT stage T1sm1/2 versus ≤pT2 versus >pT2. N stage was also compared. The MRI protocol employed a standard surface phased array coil with a high resolution (0...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29225907/changes-in-the-gut-microbiota-composition-and-the-plasma-ghrelin-level-in-patients-with-helicobacter-pylori-infected-patients-with-eradication-therapy
#20
Hidetaka Yanagi, Ayumi Tsuda, Masashi Matsushima, Shunsuke Takahashi, Genki Ozawa, Yasuhiro Koga, Atsushi Takagi
Objective: To investigate the influence of antimicrobials on both the gut microbiota structure and the plasma ghrelin level using Helicobacter pylori -infected patients who underwent eradication therapy. Design: Twenty H. pylori -infected patients (mean age 68.3 years old) who underwent eradication therapy participated in the study. For the therapy, patients had 1 week of triple therapy consisting of amoxicillin, clarithromycin and proton-pump inhibitors. Stool and blood samples were obtained before (S1), immediately after (S2) and/or 3 months after (S3) the therapies...
2017: BMJ Open Gastroenterology
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