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BMJ Open Gastroenterology

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https://www.readbyqxmd.com/read/29018541/results-from-a-retrospective-analysis-of-colonoscopies-for-inflammatory-bowel-disease-and-colorectal-cancer-in-a-lebanese-tertiary-care-centre
#1
Toufic Saber, Khalil Bedran, Fatima Ghandour, Mansour El Khoury, Roula Bou Khalil, Said Farhat
BACKGROUND AND AIMS: Inflammatory bowel diseases (IBDs) and colorectal cancer have an increased impact on the Lebanese population's morbidity and mortality. This study evaluated the situation of IBD and colorectal cancer at a tertiary hospital centre in Lebanon. METHODS: 1007 patients underwent colonoscopy over a period of 12 months by qualified physicians. 91 patients were excluded from the study. Biopsy results were divided into normal versus abnormal colonic tissue...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29018540/efficacy-of-individualised-diets-in-patients-with-irritable-bowel-syndrome-a-randomised-controlled-trial
#2
Ather Ali, Theresa R Weiss, Douglas McKee, Alisa Scherban, Sumiya Khan, Maxine R Fields, Damian Apollo, Wajahat Z Mehal
BACKGROUND: Patients with irritable bowel syndrome (IBS) are often placed on diets guided by food intolerance assays, although these have not been validated. We assessed the effects of individualised diets in patients with IBS guided by a leucocyte activation test. METHODS: This is a parallel-group, double-blind, randomised controlled trial of 58 adults with IBS seen at an academic health centre in Northeast USA. Peripheral venous blood was analysed using a leucocyte activation test; individual foods were reported to produce positive or negative results...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29018539/clinical-characteristics-of-antimitochondrial-antibody-positive-patients-at-a-safety-net-health-care-system-in-arizona
#3
Susanna Tan, Napatkamon Ayutyanont, Bikash Bhattarai, Zohreh Movahedi, Lakshmi Jayaram, Robert Gish, Abdul Nadir
BACKGROUND AND AIMS: To assess whether aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (AP) levels can predict the diagnosis of primary biliary cholangitis (PBC) or any other diagnoses and whether PBC occurs either simultaneously or independently of other liver diseases among antimitochondrial antibody (AMA)-positive patients. METHODS: Demographic and clinical variables were assessed in 90 AMA-positive patients with and without liver biopsies...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29018538/replacement-of-warfarin-with-a-novel-oral-anticoagulant-in-endoscopic-mucosal-resection-a-multicentre-open-label-randomised-controlled-trial
#4
Takuya Yamada, Akiko Kada, Toshio Uraoka, Toshio Kuwai, Noriko Watanabe, Yoshihiro Sasaki, Katsuhiro Mabe, Yasuo Takahashi, Takashi Kagaya, Toshihisa Kimura, Hiroshige Hamada, Akiko M Saito, Naohiko Harada
INTRODUCTION: This randomised controlled trial aims to compare the efficacy of warfarin replacement with apixaban without postoperative resumption of heparin with that of conventional heparin bridging in patients taking warfarin and scheduled to undergo endoscopic mucosal resection (EMR): specifically, by checking for reduction in proportion of postoperative bleeding following EMR. METHODS AND ANALYSIS: The multicentre, open-label randomised parallel-group, controlled intervention study regards patients taking warfarin who are scheduled to undergo colon EMR...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28944074/an-educational-tool-for-the-prophylaxis-of-hepatic-encephalopathy
#5
Maria Garrido, Matteo Turco, Chiara Formentin, Michela Corrias, Michele De Rui, Sara Montagnese, Piero Amodio
BACKGROUND: Providing structured information for the understanding of hepatic encephalopathy (HE) might be relevant to the prevention and management of the syndrome. The aim of our study was to design a brief, structured educational intervention and evaluate its usefulness in preventing HE-related hospitalisation over time. METHODS: Thirty-nine cirrhotic outpatients with a history of HE were enrolled and randomly assigned to an intervention (group A; n=20) or control group (group B; n=19)...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28944073/clinical-and-genetic-profile-of-patients-with-seronegative-coeliac-disease-the-natural-history-and-response-to-gluten-free-diet
#6
Maria Pina Dore, Giovanni Mario Pes, Ivana Dettori, Vincenzo Villanacci, Alessandra Manca, Giuseppe Realdi
OBJECTIVES: Patients with clinical, genetic and histological features of coeliac disease (CD), but negative for serological markers, pose a significant clinical problem. The aim of this study was to outline a specific profile, and to evaluate the natural history and response to gluten-free diet (GFD) of patients with seronegative CD. METHODS: patients with duodenal mucosa damage Marsh I, II and III stages, HLA DQ2/DQ8 haplotype and clinical features suggestive of CD, but negative for CD serology, were defined as seronegative CD patients...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28944072/close-observation-versus-upfront-treatment-in-hepatocellular-carcinoma-are-the-exception-points-worth-the-risk
#7
Danielle M Tholey, Ben Hornung, Charles K Enestvedt, Yiyi Chen, Willscott S Naugler, Khashayar Farsad, Nima Nabavizadeh, Barry Schlansky, Joseph Ahn, Janice H Jou
INTRODUCTION: To assess the outcomes of immediate LDT versus observation strategies for T1 hepatocellular carcinoma (HCC) with respect to progression beyond Milan and survival. METHOD: T1 HCCs were retrospectively reviewed from a multidisciplinary tumour board database between September 2007 and May 2015. In the observation group, T1 lesions were observed until the tumour grew to meet T2 criteria (=2 cm). The treatment group consisted of T1 lesions treated at diagnosis with liver directed therapy (LDT)...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28944071/prevalence-and-screening-for-anaemia-in-mild-to-moderate-crohn-s-disease-and-ulcerative-colitis-in-the-united-states-2010-2014
#8
Eboselume Akhuemonkhan, Alyssa Parian, Kay Miller, Stephen Hanauer, Susan Hutfless
BACKGROUND AND AIMS: Anaemia affects up to 74% patients with Crohn's disease (CD) and ulcerative colitis (UC) and is correlated with decreased quality of life. The European Crohn's and Colitis Organisation (ECCO) recommends at least annual screening for iron-deficiency anaemia. We aimed to determine the prevalence of anaemia, frequency of anaemia screening and factors associated with anaemia in a retrospective study of mild to moderate inflammatory bowel disease (IBD) in the USA. METHODS: Adults with at least two outpatient encounters for IBD between 2010 through 2014 who contributed laboratory information were identified from MarketScan, a US commercial claims database...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28944070/rifaximin-versus-norfloxacin-for-prevention-of-spontaneous-bacterial-peritonitis-a-systematic-review
#9
Gurpartap S Sidhu, Andrew Go, Bashar M Attar, Hemant R Mutneja, Shilpa Arora, Sanjay A Patel
AIM: The aim of this systematic review is to evaluate the efficacy and safety of rifaximin in the prophylaxis of spontaneous bacterial peritonitis (SBP) as compared with norfloxacin. METHODS: We searched MEDLINE, CINAHL, Google Scholar and Cochrane databases from inception to January 2017. Reference lists of articles as well as conference proceedings were manually screened. We included studies that recruited patients with cirrhosis and ascites who met the criteria for primary or secondary SBP prophylaxis as defined by the European Association for the Study of the Liver and American Association for the Study of Liver Diseases...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28944069/weight-regain-after-roux-en-y-gastric-bypass-has-a-large-negative-impact-on-the-bariatric-quality-of-life-index
#10
Pichamol Jirapinyo, Barham K Abu Dayyeh, Christopher C Thompson
BACKGROUND: Despite initial successful weight loss, some patients may experience weight regain following Roux-en-Y gastric bypass (RYGB). OBJECTIVE: To assess the impact of weight regain on bariatric patients' quality of life (QoL). METHODS: This was a prospective cross-sectional study. Fifty-six consecutive RYGB patients were recruited and divided into weight-regain and weight-stable cohorts. QoL was assessed using the Bariatric Quality of Life (BQL) questionnaire...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28944068/comparison-of-outcomes-between-symptomatic-and-asymptomatic-patients-with-colorectal-cancer-a-propensity-score-matched-analysis-of-surgical-invasiveness-medical-costs-and-oncological-outcomes
#11
Ryo Inada, Takeshi Nagasaka, Ayako Watanabe, Tomohiko Yagi, Yoshiko Mori, Yoshitaka Kondo, Hiroyuki Kishimoto, Yuzo Umeda, Toshiyoshi Fujiwara
BACKGROUND AND AIMS: Whether asymptomatic patients with colorectal cancer (CRC) who are treated in hospitals show better outcomes than symptomatic patients with CRC still remains unknown. The aim of this study was to evaluate differences in clinical benefits following treatment in asymptomatic and symptomatic patients with CRC. METHODS: This study was a retrospective cohort analysis with data obtained from records. A cohort of 145 asymptomatic and 123 symptomatic patients who underwent CRC surgery between January 2009 and December 2011 was enrolled...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28944067/intestinal-microbiota-is-altered-in-patients-with-colon-cancer-and-modified-by-probiotic-intervention
#12
Ashley A Hibberd, Anna Lyra, Arthur C Ouwehand, Peter Rolny, Helena Lindegren, Lennart Cedgård, Yvonne Wettergren
OBJECTIVE: The colonic microbiota is altered in patients with colorectal cancer (CRC). We investigated the microbiota composition of patients with colon cancer compared with controls devoid of neoplastic or inflammatory disease and the potential to modify the colonic microbiota with probiotics. DESIGN: Biopsy samples were obtained from the normal mucosa and tumour during colonoscopy from 15 patients with colon cancer. Subsequent patient-matched samples were taken at surgery from the tumour and nearby mucosa from the patients with cancer, eight of whom had received two daily tablets totalling 1...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28761693/effect-of-dexmedetomidine-in-the-prophylactic-endoscopic-injection-sclerotherapy-for-oesophageal-varices-a-study-protocol-for-prospective-interventional-study
#13
Hiroki Nishikawa, Yoshinori Iwata, Akio Ishii, Hirayuki Enomoto, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Kazunori Yoh, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
BACKGROUND: Dexmedetomidine (DEX) is a novel, highly selective α2-adrenoceptor agonist that elicits sedative, amnestic, sympatholytic and analgesic effects in patients. Several Japanese investigators have reported the clinical usefulness of DEX for sedation in endoscopic therapies for gastrointestinal malignancies; however, there have been limited data regarding the usefulness and safety of DEX for sedation during endoscopic procedures for oesophageal varices (OVs), such as endoscopic injection sclerotherapy (EIS)...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28761692/alteration-in-the-gastric-microbiota-and-its-restoration-by-probiotics-in-patients-with-functional-dyspepsia
#14
Muneki Igarashi, Hirohiko Nakae, Takashi Matsuoka, Shunsuke Takahashi, Takayoshi Hisada, Junko Tomita, Yasuhiro Koga
OBJECTIVE: The objective of this study was to comparatively analyse the gastric fluid (GF) microbiota between patients with functional dyspepsia (FD) and healthy controls (HC), and to assess the effect of probiotics on the microbiota. DESIGN: Twenty-four Japanese patients with FD who met the Rome III definition and 21 age-matched and gender-matched HC volunteers were enrolled. The patients with FD had been treated with LG21, a probiotic strain. The GF was sampled after an overnight fast using a nasogastric tube...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28761691/impact-of-feedback-and-monitoring-on-colonoscopy-withdrawal-times-and-polyp-detection-rates
#15
Amalie Bach Nielsen, Ole Haagen Nielsen, Jakob Hendel
BACKGROUND: Previous studies have shown colonoscopy withdrawal time (WT) to be a reliable surrogate indicator for polyp detection rate (PDR) and adenoma detection rate (ADR) in colonoscopy. Our aim was to assess the impact of feedback and monitoring of WT on PDR in routine colonoscopies with long-term follow-up. MATERIALS AND METHODS: A total of 307 colonoscopies were performed in three separate clinical scenarios. First, PDR and WT were recorded without the staff being aware of the specific objective of the study...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28761690/duodenal-biopsies-for-the-diagnosis-of-coeliac-disease-are-we-adhering-to-current-guidance
#16
Nilofer Husnoo, Wafaa Ahmed, Muhammad Hanif Shiwani
BACKGROUND: The British Society of Gastroenterology guidelines recommend taking at least four duodenal biopsy specimens at the time of upper gastrointestinal (UGI) endoscopy if coeliac disease (CD) is suspected and it has been shown to increase the diagnostic yield of CD. We assessed the compliance to these guidelines within our institution. We then applied measures to improve our compliance rate and assessed the resulting impact on our diagnostic rate of CD. METHODS: We performed a retrospective audit of electronic records for all patients, with no prior diagnosis of CD, who underwent UGI endoscopy with duodenal biopsies between August 2014 and May 2015...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28761689/efficacy-of-dietary-and-physical-activity-intervention-in-non-alcoholic-fatty-liver-disease-a-systematic-review
#17
Susan Kenneally, Joanna H Sier, J Bernadette Moore
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, with prevalence above 30% in many adult populations. Strongly associated with obesity, weight loss through diet and physical activity is the mainstay of its management. Weight loss can be difficult to achieve and maintain however, and uncertainty exists as to which lifestyle changes are most effective. OBJECTIVE: The aim of this work was to systematically evaluate randomised controlled trials assessing diet, exercise or combination interventions aimed at reducing steatosis or markers of NAFLD activity...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28761688/epidemiology-of-coeliac-disease-in-a-single-centre-in-southern-derbyshire-1958-2014
#18
Geoffrey K T Holmes, A Muirhead
OBJECTIVE: To determine trends in diagnosis of coeliac disease (CD) in patients attending a single centre 1958-2014 and provide figures for prevalence and incidence in those born in Derby city over 4 decades. To explore a link between deprivation and prevalence and characteristics of CD in Asians. DESIGN: An unselected, consecutive series of 2410 adult patients with CD diagnosed in the catchment area of the Derby hospitals was identified. 1077 born within Derby city identified by postcodes was used to determine changes in prevalence and incidence over 4 decades...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28761687/systemic-sclerosis-is-associated-with-specific-alterations-in-gastrointestinal-microbiota-in-two-independent-cohorts
#19
Elizabeth R Volkmann, Anna-Maria Hoffmann-Vold, Yu-Ling Chang, Jonathan P Jacobs, Kirsten Tillisch, Emeran A Mayer, Philip J Clements, Johannes R Hov, Martin Kummen, Øyvind Midtvedt, Venu Lagishetty, Lin Chang, Jennifer S Labus, Øyvind Molberg, Jonathan Braun
OBJECTIVE: To compare faecal microbial composition in patients with systemic sclerosis (SSc) from 2 independent cohorts with controls and to determine whether certain genera are associated with SSc-gastrointestinal tract (GIT) symptoms. DESIGN: Adult patients with SSc from the University of California, Los Angeles (UCLA) and Oslo University Hospital (OUH) and healthy controls participated in this study (1:1:1). All participants provided stool specimens for 16S rRNA sequencing...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28761686/quality-of-life-and-psychological-and-gastrointestinal-symptoms-after-cholecystectomy-a-population-based-cohort-study
#20
Arne Talseth, Tom-Harald Edna, Kristian Hveem, Stian Lydersen, Eivind Ness-Jensen
OBJECTIVE: The study aims to examine gastrointestinal symptoms, quality of life and the risk of psychological symptoms after cholecystectomy. DESIGN: This is a prospective population-based cohort study based on the Nord-Trøndelag Health Study (HUNT) Norway. HUNT is a repeated health survey of the county population and includes a wide range of health-related items. In the present study, all 3 HUNT surveys were included, performed between 1984 and 2008. Selected items were scores on quality of life, the Hospital Anxiety and Depression Scale (HADS) and selected gastrointestinal symptoms...
2017: BMJ Open Gastroenterology
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