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BMJ Open Gastroenterology

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https://www.readbyqxmd.com/read/30073092/growth-patterns-of-colorectal-cancer-liver-metastases-and-their-impact-on-prognosis-a-systematic-review
#1
Carlos Fernández Moro, Béla Bozóky, Marco Gerling
Background: Colorectal cancer liver metastases (CRLM) grow in distinct histological patterns that have been associated with outcome after surgical resection. We conducted a systematic review to evaluate the frequency of different CRLM growth patterns and their impact on prognosis. Methods: We searched Embase and MEDLINE databases from inception to 1 December 2017 to identify studies that reported CRLM growth pattern histopathology, their frequencies, and/or data related to outcome...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/30073091/tnf%C3%AE-inhibitors-exacerbate-mycobacterium-paratuberculosis-infection-in-tissue-culture-a-rationale-for-poor-response-of-patients-with-crohn-s-disease-to-current-approved-therapy
#2
Ahmad Qasem, Saleh A Naser
Background The role of Mycobacteriumavium subspecies paratuberculosis (MAP) in Crohn's disease (CD) is increasingly accepted as evident by detection of the bacteria in the blood and intestinal tissue from patients with CD, and by supporting data from several open-label anti-MAP treatment studies. Tumour necrosis factor alpha (TNFα) monoclonal antibodies (anti-TNFα) have been widely used for CD treatment. Despite the short-term benefit of anti-TNFα in controlling CD symptoms, most patients suffer from detrimental adverse effects, including higher susceptibility to mycobacterial infections...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/30073090/clinical-and-manometric-characteristics-of-patients-with-oesophagogastric-outflow-obstruction-towards-a-new-classification
#3
George Triadafilopoulos, John O Clarke
Background: The Chicago Classification (CC) defines oesophagogastric junction outflow obstruction (EGJOO) as the presence of an elevated integrated residual pressure (IRP) together with preserved oesophageal body peristalsis but its clinical significance is evolving. Aims: To describe the clinical and manometric characteristics in patients with EGJOO and propose a new classification. Methods: In this retrospective cohort study, patients with functional oesophageal symptoms underwent clinical and endoscopic assessment and oesophageal high-resolution manometry (HRM)...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/30002864/golimumab-induction-and-maintenance-for-moderate-to-severe-ulcerative-colitis-results-from-go-colitis-golimumab-a-phase-4-uk-open-label-single-arm-study-on-its-utilization-and-impact-in-ulcerative-colitis
#4
Christopher Sj Probert, Shaji Sebastian, Daniel R Gaya, P John Hamlin, Gillian Gillespie, Anita Rose, Helen Tate, Colin Wheeler, Peter M Irving
Objective: GO-COLITIS aimed to measure the effectiveness of subcutaneous golimumab in tumour necrosis factor-α antagonist-naive patients with moderate to severe ulcerative colitis (UC) despite conventional treatment. Design: GO-COLITIS was an open label, single arm, phase 4 study with a pragmatic design which reflected UK clinical practice. Adult patients were eligible if diagnosed with UC ≥3 months, partial Mayo score (PMS) 4-9. Patients received subcutaneous golimumab induction (200 mg initially and 100 mg at week 2) followed at week 6 by 50 mg or 100 mg (depending on weight) every 4 weeks until week 54 with a 12-week follow-up...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/30002863/real-world-effectiveness-of-sofosbuvir-plus-ribavirin-for-chronic-hepatitis-c-genotype-2-in-asia-a-systematic-review-and-meta-analysis
#5
Bin Wei, Fanpu Ji, Yee Hui Yeo, Eiichi Ogawa, Biyao Zou, Christopher D Stave, Shuangsuo Dang, Zongfang Li, Norihiro Furusyo, Ramsey C Cheung, Mindie H Nguyen
Background: Sofosbuvir plus ribavirin (SOF+RBV) for 12 weeks is the standard treatment for chronic hepatitis C (CHC) genotype 2 (GT2) in most of Asia despite availability of new CHC medications. SOF-RBV real-world effectiveness has only been reported in small and/or single-centre studies. Our goal was to determine the real-world effectiveness of 12-week SOF+RBV therapy for CHC GT2 in Asia. Methods: A systematic search on PubMed and Embase was conducted through 30 June 2017...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29915668/study-to-determine-the-likely-accuracy-of-ph-testing-to-confirm-nasogastric-tube-placement
#6
Anne M Rowat, Catriona Graham, Martin Dennis
Objective: To establish the likely accuracy of pH testing to identify gastric aspirates at different pH cut-offs to confirm nasogastric tube placement. Methods: This prospective observational study included a convenience sample of adult patients who had two (one fresh and one frozen) gastric and oesophageal samples taken during gastroscopy or two bronchial and saliva samples taken during bronchoscopy. The degree of observer agreement for the pH of fresh and frozen samples was indicted by kappa ( k ) statistics...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29915667/putative-biomarkers-of-vedolizumab-resistance-and-underlying-inflammatory-pathways-involved-in-ibd
#7
Christoffer Soendergaard, Jakob Benedict Seidelin, Casper Steenholdt, Ole Haagen Nielsen
Objectives: Characterise the circulating inflammatory cytokine pattern among patients failing consecutive anti-tumour necrosis factor (anti-TNF) and anti-integrin treatments to identify predictors of response. Methods: A retrospective single-centre cohort study of 28 patients with inflammatory bowel disease (IBD) receiving anti-integrin therapy (vedolizumab) subsequent to the failure of anti-TNF treatment was conducted. Blood samples were obtained immediately prior to initiation of vedolizumab therapy, and the response to treatment was evaluated after completion of the 14-week induction regimen...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29915666/evaluation-of-amnion-derived-mesenchymal-stem-cells-for-treatment-resistant-moderate-crohn-s-disease-study-protocol-for-a-phase-i-ii-dual-centre-open-label-uncontrolled-dose-response-trial
#8
Shinsuke Otagiri, Shunsuke Ohnishi, Arisa Miura, Hiroshi Hayashi, Izumi Kumagai, Yoichi M Ito, Takehiko Katsurada, Shiro Nakamura, Rika Okamoto, Kenichi Yamahara, Kyu Yong Cho, Toshiyuki Isoe, Norihiro Sato, Naoya Sakamoto
Introduction: The medical treatment options for patients with Crohn's disease (CD) are limited and patients resistant to those therapies are left requiring surgical operations that usually only achieve some symptomatic relief. Mesenchymal stem cells (MSC) have been shown to be effective for the treatment of CD, and we have demonstrated in animal experiments that human amnion-derived MSCs (AMSC) are a potential new therapeutic strategy. Therefore, we designed this study to investigate the safety and efficacy of AMSCs in patients with treatment-resistant CD...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29915665/peribiliary-cysts-a-systematic-review-and-proposal-of-a-classification-framework
#9
Fateh Bazerbachi, Samir Haffar, Takaaki Sugihara, Taofic M Mounajjed, Naoki Takahashi, Mohammad Hassan Murad, Barham K Abu Dayyeh
Objective: Peribiliary cysts are usually benign, although severe complications and mortality may occur, and they may be confounded with other diseases. No classification delineating their different characteristics exists. Design: We performed a systematic review of the frequency and clinical manifestations of peribiliary cysts. Two reviewers identified studies after searching multiple databases on 2 August 2017. Results: These cysts were prevalent in cirrhosis (9%)...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29755758/autoantibodies-in-chronic-hepatitis-c-virus-infection-impact-on-clinical-outcomes-and-extrahepatic-manifestations
#10
Andrew J Gilman, An K Le, Changqing Zhao, Joseph Hoang, Lee A Yasukawa, Susan C Weber, John M Vierling, Mindie H Nguyen
Goals: To examine the role that autoantibodies (auto-abs) play in chronic hepatitis C virus (HCV) regarding demographics, presence of extrahepatic manifestations and long-term outcomes in a large US cohort. Background: Auto-abs have been reported to be prevalent in patients with chronic HCV infection, but data on the natural history of these patients are limited. Study: The study included 1556 consecutive patients with HCV without concurrent HIV and/or HBV who had testing for antinuclear antibody (ANA), antimitochondrial antibody (AMA), antismooth muscle antibody (ASMA) and/or antiliver kidney microsomal antibody (LKM)...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29686881/mortality-in-coeliac-disease-a-population-based-cohort-study-from-a-single-centre-in-southern-derbyshire-uk
#11
Geoffrey K T Holmes, Andrew Muirhead
Objective: With the advent of screening tests, it was hypothesised that milder cases of coeliac disease coming to diagnosis might have reduced risk of mortality. An earlier publication did not support this view. We have re-examined this issue employing a larger number of patients followed for a further 8 years. Design: Patients with coeliac disease from Southern Derbyshire, UK, were followed prospectively from 1978 to 2014 and included those diagnosed by biopsy and serology...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29607054/non-alcoholic-steatofibrosis-nasf-can-independently-predict-mortality-in-patients-with-non-alcoholic-fatty-liver-disease-nafld
#12
Pegah Golabi, Maria Stepanova, Huong T Pham, Rebecca Cable, Nila Rafiq, Haley Bush, Trevor Gogoll, Zobair M Younossi
Background: Hepatic fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) independently predicts mortality. Given liver biopsy's invasive nature, non-invasive method to assess hepatic steatosis and fibrosis provides NAFLD risk stratification algorithm in clinical practice. NAFLD fibrosis score (NFS) is simple and non-invasive predictive model recommended by American Association for the Study of Liver Disease (AASLD) Guideline to identify patients with NAFLD with fibrosis risk...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29607053/rate-of-hepatocellular-carcinoma-surveillance-remains-low-for-a-large-real-life-cohort-of-patients-with-hepatitis-c-cirrhosis
#13
Sally Ann Tran, An Le, Changqing Zhao, Joseph Hoang, Lee Ann Yasukawa, Susan Weber, Linda Henry, Mindie H Nguyen
Background: In patients with chronic hepatitis C (CHC) cirrhosis, imaging for hepatocellular carcinoma (HCC) is recommended every 6 months to maximise eligibility for curative treatment. The aim was to determine the adherence rate and outcomes among patients with CHC cirrhosis and whether the adherence rate has improved over time. Methods: Retrospective cohort study of patients with CHC cirrhosis (n=2366) monitored for ≥1 year at Stanford University Medical Center between January 2001 and August 2015...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29607052/changing-nationwide-trends-in-endoscopic-medical-and-surgical-admissions-for-inflammatory-bowel-disease-2003-2013
#14
Ahmir Ahmad, Anthony A Laverty, Chris Alexakis, Tom Cowling, Sonia Saxena, Azeem Majeed, Richard C G Pollok
Background and study aims: In the last decade, there have been major advances in inflammatory bowel disease (IBD) management but their impact on hospital admissions requires evaluation. We aim to investigate nationwide trends in IBD surgical/medical elective and emergency admissions, including endoscopy and cytokine inhibitor infusions, between 2003 and 2013. Patients and methods: We used Hospital Episode Statistics and population data from the UK Office for National Statistics...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29527318/study-for-every-other-day-administration-of-vonoprazan-in-maintenance-treatment-of-erosive-gerd-study-protocol-for-a-multicentre-randomised-cross-over-study
#15
Mototsugu Kato, Noriko Ito, Mamiko Demura, Kimitoshi Kubo, Katsuhiro Mabe, Naohiko Harada
Introduction: The first drug selected for treatment of gastro-oesophageal reflux disease (GERD) and prevention of the recurrence is a proton pump inhibitor (PPI), but recently, a potassium-competitive acid blocker (P-CAB) was put on the market in Japan. Its onset of effect is faster than PPI, and it takes more than 2 days to recover acid secretion after the withdrawal period. Therefore, unlike PPI, the usefulness of every other day administration or discontinuous administration is expected...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29527317/implication-of-exercise-interventions-on-sleep-disturbance-in-patients-with-pancreatic-cancer-a-study-protocol-for-a-randomised-controlled-trial
#16
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Noriko Ishii, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction and purpose: Patients with pancreatic cancer (PC) have long been known to have high rates of depression. Depression in patients with PC can be linked to sleep disturbance. The American College of Sports Medicine notes that physical exercise is safe for most patients with cancer and physical inactivity should be avoided. However, clinical impacts of exercise interventions (EIs) on patients with PC have been poorly investigated. We aim to prospectively examine the effect of EIs on sleep disturbance in patients with PC using actigraphy, which is an objective measurement of motor activity and sleep...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29527316/outcome-of-tacrolimus-and-vedolizumab-after-corticosteroid-and-anti-tnf-failure-in-paediatric-severe-colitis
#17
Blaise Hamel, May Wu, Elizabeth O Hamel, Dorsey M Bass, K T Park
Background: Severe colitis flare from ulcerative colitis (UC) or Crohn's disease (CD) may be refractory to corticosteroids and antitumour necrosis factor (TNF) agents resulting in high colectomy rates. We aimed to describe the utility of tacrolimus to prevent colectomy during second-line vedolizumab initiation after corticosteroid and anti-TNF treatment failure in paediatric severe colitis. Methods: A retrospective cohort analysis was performed between 1 October 2014 and 31 October 2016 at a single tertiary care centre...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29527315/effect-of-exercise-therapy-on-sarcopenia-in-pancreatic-cancer-a-study-protocol-for-a-randomised-controlled-trial
#18
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Noriko Ishii, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction and purpose: Sarcopenia is defined as a decrease in muscle mass and muscle strength, and it has been demonstrated to be an adverse predictor in numerous types of cancers. Exercise therapy (ET) carries multiple health benefits in several diseases. Despite these clinical benefits, there are limited data available regarding patients with pancreatic cancer (PC) undergoing ET. We aim to prospectively examine the effect of ET on sarcopenia in patients with PC. Methods and analysis: All clinical stages of PC can be included...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29527314/clinical-impact-of-physical-exercise-on-sleep-disorder-as-assessed-by-actigram-in-patients-with-chronic-pancreatitis-a-study-protocol-for-a-randomised-controlled-trial
#19
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction: In most chronic pancreatitis (CP) cases, malabsorption, pain, and weight loss are the leading clinical symptoms, which significantly worsen the quality of life (QOL) and decreased QOL in patients with CP can cause sleep disorder. There is a growing body of evidence that recognises the favourable effects of physical exercise (PE), however, there are limited data currently available concerning patients with CP undergoing PE. Actigram is a device for gathering objective sleep/awake data in the natural sleeping surroundings over an extended time period...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29527313/a-randomised-controlled-trial-of-gemcitabine-hydrochloride-plus-s-1-combination-therapy-versus-gemcitabine-hydrochloride-therapy-alone-in-pancreatic-cancer-patients-aged-%C3%A2-75-years-a-study-protocol-for-an-open-label-randomised-feasibility-study
#20
Hiroshi Ishii, Natsumi Yamashita, Makoto Ueno, Shinichi Ohkawa, Akiko M Saito, Mitsugu Sekimoto
Introduction: In Japan, the age of patients with pancreatic cancer has increased. Combination chemotherapies such as 5-fluorouracil/leucovorin, oxaliplatin and irinotecan therapy and gemcitabine hydrochloride (GEM) +nab paclitaxel therapy have been developed as the standard treatments for young patients with advanced recurrent pancreatic cancer. However, both therapies produce toxicity and their administration is limited by the patients' age or performance status. The efficacy and safety data obtained in the GEST study-a large-scale randomised controlled study conducted in patients with pancreatic cancer in Japan-suggested that GEM +S-1 (GS) combination therapy is a promising candidate for those aged between 75 and 80 years...
2018: BMJ Open Gastroenterology
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