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BMJ Open Gastroenterology

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https://www.readbyqxmd.com/read/29379609/protocol-for-a-multicentred-randomised-controlled-trial-investigating-the-use-of-personalised-golimumab-dosing-tailored-to-inflammatory-load-in-ulcerative-colitis-the-goal-arc-study-glm-dose-optimisation-to-adequate-levels-to-achieve-response-in-colitis-led
#1
Juliette Sheridan, Carol Ann Coe, Peter Doran, Laurence Egan, Garret Cullen, David Kevans, Jan Leyden, Marie Galligan, Aoibhlinn O'Toole, Jane McCarthy, Glen Doherty
Introduction: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD), often leading to an impaired quality of life in affected patients. Current treatment modalities include antitumour necrosis factor (anti-TNF) monoclonal antibodies (mABs) including infliximab, adalimumab and golimumab (GLM). Several recent retrospective and prospective studies have demonstrated that fixed dosing schedules of anti-TNF agents often fails to consistently achieve adequate circulating therapeutic drug levels (DL) with consequent risk of immunogenicity treatment failure and potential risk of hospitalisation and colectomy in patients with UC...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29333278/clinical-influence-of-exercise-therapy-on-sarcopenia-in-patients-with-chronic-pancreatitis-a-study-protocol-for-a-randomised-controlled-trial
#2
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction and purpose: Chronic pancreatitis (CP) involves progressive inflammatory changes to the pancreas and can lead to permanent structural damage and impairment of both endocrine and exocrine functions. Current reports highlight a rise in the incidence and prevalence of CP. However, there is limited data currently available concerning patients with CP undergoing exercise therapy (ET). We aim to prospectively examine the influence of ET on sarcopenia in patients with CP. Methods and analysis: A detailed evaluation of the nutritional condition and the daily physical activities of each participant will be conducted prior to entering the study...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29333277/familial-risks-for-gallstones-in-the-population-of-sweden
#3
Kari Hemminki, Otto Hemminki, Asta Försti, Kristina Sundquist, Jan Sundquist, Xinjun Li
Objectives: Gallstone disease (cholelithiasis) has a familial component, but detailed data on the modification of familial risk are lacking. Using nationwide hospital and population records, we aimed to determine detailed familial risks for medically diagnosed gallstone disease. Design: Subjects were obtained from the Multigeneration Register, which contains family data on the Swedish population, and patients with gallstone disease were identified from the Hospital Discharge Register (1964-2015) and the Outpatient Register (2001-2015)...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29333276/neuropsychiatric-performance-and-treatment-of-hepatitis-c-with-direct-acting-antivirals-a-prospective-study
#4
Sofia Volpato, Sara Montagnese, Alberto Zanetto, Matteo Turco, Michele De Rui, Alberto Ferrarese, Piero Amodio, Giacomo Germani, Marco Senzolo, Martina Gambato, Francesco Paolo Russo, Patrizia Burra
Background: Since direct-acting antivirals (DAAs) have been approved for the treatment of hepatitis C virus (HCV) infection, a small series of patients with new-onset neuropsychiatric alterations have been referred to us. We therefore set out to study neuropsychiatric function in relation to DAAs prospectively. Methods: Ten patients with cirrhosis and 12 post-liver transplant (post-LT) patients were enrolled. All underwent wake electroencephalography (EEG) and a neuropsychological evaluation (paper and pencil battery, simple/choice reaction times, working memory task) at baseline, at the end of treatment with DAAs and after 6 months...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29333275/barriers-to-care-for-chronic-hepatitis-c-in-the-direct-acting-antiviral-era-a-single-centre-experience
#5
Peter Nguyen, Philip Vutien, Joseph Hoang, Sam Trinh, An Le, Lee Ann Yasukawa, Susan Weber, Linda Henry, Mindie H Nguyen
Background: Cure rates for chronic hepatitis C have improved dramatically with direct-acting antivirals (DAAs), but treatment barriers remain. We aimed to compare treatment initiation rates and barriers across both interferon-based and DAA-based eras. Methods: We conducted a retrospective cohort study of all patients with chronic hepatitis C seen at an academic hepatology clinic from 1999 to 2016. Patients were identified to have chronic hepatitis C by the International Classification of Diseases, Ninth Revision codes, and the diagnosis was validated by chart review...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29259793/effect-of-physical-exercise-on-sarcopaenia-in-patients-with-overt-hepatic-encephalopathy-a-study-protocol-for-a-randomised-controlled-trial
#6
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction: Limited data are currently available for patients with overt hepatic encephalopathy (OHE)) receiving physical exercise (PE). The aim of the current study is to prospectively examine the effect of PE on sarcopaenia in patients with OHE. Methods and analysis: At the time of patient recruitment, a precise assessment for nutritional status and daily physical activities will be performed in each subject. Study participants will be randomly assigned into two groups: (1) the PE group and (2) the control group...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29259792/pcr-detection-of-segmented-filamentous-bacteria-in-the-terminal-ileum-of-patients-with-ulcerative-colitis
#7
Alessia Finotti, Jessica Gasparello, Ilaria Lampronti, Lucia Carmela Cosenza, Giovanni Maconi, Vincenzo Matarese, Valentina Gentili, Dario Di Luca, Roberto Gambari, Michele Caselli
Objectives: Segmented filamentous bacteria (SFB) have been detected in a wide range of different animal. Recently, the presence of SFB-like bacteria was shown in biopsies of the terminal ileum and ileocecal valve of both patients with ulcerative colitis and control subjects. The aim of this study was to verify whether PCR methods could be used for the detection of SFB in biopsy of patients with ulcerative colitis and its relationships with the disease stage. Methods: PCR methods were used to identify SFB in biopsies from the terminal ileum of patients with ulcerative colitis, showing that this approach represents a useful tool for the detection of SFB presence and analysis of the bacterial load...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29259791/diagnostic-accuracy-of-high-resolution-mri-as-a-method-to-predict-potentially-safe-endoscopic-and-surgical-planes-in-patients-with-early-rectal-cancer
#8
Svetlana Balyasnikova, James Read, Andrew Wotherspoon, S Rasheed, Paris Tekkis, Diana Tait, David Cunningham, G Brown
Introduction: Early rectal cancer (ERC) assessment should include prediction of the potential excision plane to safely remove lesions with clear deep margins and feasibility of organ preservation. Method: MRI accuracy for differentiating ≤T1sm2 (partially preserved submucosa) or ≤T2 (partially preserved muscularis) versus >T2 tumours was compared with the gold standard of pT stage T1sm1/2 versus ≤pT2 versus >pT2. N stage was also compared. The MRI protocol employed a standard surface phased array coil with a high resolution (0...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29225907/changes-in-the-gut-microbiota-composition-and-the-plasma-ghrelin-level-in-patients-with-helicobacter-pylori-infected-patients-with-eradication-therapy
#9
Hidetaka Yanagi, Ayumi Tsuda, Masashi Matsushima, Shunsuke Takahashi, Genki Ozawa, Yasuhiro Koga, Atsushi Takagi
Objective: To investigate the influence of antimicrobials on both the gut microbiota structure and the plasma ghrelin level using Helicobacter pylori-infected patients who underwent eradication therapy. Design: Twenty H. pylori-infected patients (mean age 68.3 years old) who underwent eradication therapy participated in the study. For the therapy, patients had 1 week of triple therapy consisting of amoxicillin, clarithromycin and proton-pump inhibitors. Stool and blood samples were obtained before (S1), immediately after (S2) and/or 3 months after (S3) the therapies...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29177066/non-acid-gastro-oesophageal-reflux-is-associated-with-squamous-cell-carcinoma-of-the-oesophagus
#10
Mpho Kgomo, Taole R Mokoena, James A Ker
Introduction: Squamous cell carcinoma of the oesophagus is a common cancer among South Africans. Due to the absence of effective screening and surveillance programme for early detection and late presentation, squamous cell carcinoma of the oesophagus is usually diagnosed at an advanced stage or when metastasis has already occurred. The 5-year survival is often quoted at 5%-10%, which is poor. Objectives: To determine the association between oesophageal squamous cell carcinoma (OSCC) and non-acid gastro-oesophageal reflux disease...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29177065/patients-with-symptoms-of-delayed-gastric-emptying-have-a-high-prevalence-of-oesophageal-dysmotility-irrespective-of-scintigraphic-evidence-of-gastroparesis
#11
George Triadafilopoulos, Linda Nguyen, John O Clarke
Background: Patients with symptoms suggestive of gastroparesis exhibit several symptoms, such as epigastric pain, postprandial fullness, bloating and regurgitation. It is uncertain if such symptoms reflect underlying oesophageal motor disorder. Aims: To examine whether patients with epigastric pain and postprandial distress syndrome suggestive of functional dyspepsia and/or gastroparesis also have concomitant oesophageal motility abnormalities and, if so, whether there are any associations between these disturbances...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29177064/efficacy-of-capsule-endoscopy-in-patients-with-cirrhosis-for-the-diagnosis-of-upper-gastrointestinal-lesions-and-small-bowel-abnormalities-a-study-protocol-for-prospective-interventional-study
#12
Yoshinori Iwata, Hiroki Nishikawa, Hirayuki Enomoto, Kazunori Yoh, Akio Ishii, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction and aims: The role of capsule endoscopy (CE) in patients with liver cirrhosis (LC) has yet to be established; however, it is likely that it will remain a valuable diagnostic modality in several groups of patients with LC. The primary aims of the current prospective interventional study are to examine the prevalence for small bowel lesions and transit time of CE in the gastrointestinal tract in patients with LC with oesophageal varices (EVs) requiring endoscopic therapies...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29177063/circulating-micrornas-as-potential-biomarkers-to-detect-transformation-of-barrett-s-oesophagus-to-oesophageal-adenocarcinoma
#13
Juntaro Matsuzaki, Hidekazu Suzuki
Objective: Circulating microRNAs (miRNAs) are promising biomarkers for the early detection of cancers. This study aimed to address potential circulating miRNAs to monitor the progression from Barrett's oesophagus (BO) to oesophageal adenocarcinoma (OAC). Design: We comprehensively analysed tissue and serum miRNA expression profiles of BO mice model (L2-interleukin-1β (IL-1β) mice) using microarray analysis. To validate the data from mice, a published dataset of human plasma miRNAs, consisting of eight patients with OAC, eight with BO and six healthy controls, was used (GSE51410)...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29177062/validity-of-studies-suggesting-postsurgical-chemotherapy-for-resectable-gastric-cancer-critical-appraisal-of-randomised-trials
#14
Giulia Manzini, Doris Henne-Bruns, Michael Kremer
Background and aim: In 2013, Diaz-Nieto et al published a Cochrane review to summarise the impact of postsurgical chemotherapy versus surgery alone on survival for resectable gastric cancer. The authors concluded that postsurgical chemotherapy showed an improvement in overall survival. The aim of this article was to assess the validity of four studies included in the Cochrane review and to investigate the impact of an exclusion of these four studies on the result of the meta-analysis...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29119003/novel-associations-of-bile-acid-diarrhoea-with-fatty-liver-disease-and-gallstones-a-cohort-retrospective-analysis
#15
Richard N Appleby, Jonathan D Nolan, Ian M Johnston, Sanjeev S Pattni, Jessica Fox, Julian Rf Walters
Background: Bile acid diarrhoea (BAD) is a common cause of chronic diarrhoea with a population prevalence of primary BAD around 1%. Previous studies have identified associations with low levels of the ileal hormone fibroblast growth factor 19 (FGF19), obesity and hypertriglyceridaemia. The aim of this study was to identify further associations of BAD. Methods: A cohort of patients with chronic diarrhoea who underwent 75selenohomocholic acid taurate (SeHCAT) testing for BAD was further analysed retrospectively...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29119002/mechanisms-of-liver-disease-in-patients-infected-with-hiv
#16
REVIEW
Matthew B Kaspar, Richard K Sterling
Objective: To describe the various mechanisms of liver disease in patients with HIV infection, and to link these mechanisms to disease states which may utilise them. Background: Non-AIDS causes of morbidity and mortality are becoming increasingly common in patients chronically infected with HIV. In particular, liver-related diseases have risen to become one of the leading causes of non-AIDS-related death. A thorough understanding of the mechanisms driving the development of liver disease in these patients is essential when evaluating and caring for these patients...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29119001/a-swedish-national-adoption-study-of-risk-of-irritable-bowel-syndrome-ibs
#17
Rasmus Waehrens, Bengt Zöller, Jan Sundquist, Kristina Sundquist, MirNabi Pirouzifard
Objectives: Irritable bowel syndrome (IBS) clusters in families, but the familial risk of IBS has not been determined in adoptees. Studying adoptees and their biological and adoptive parents is a strong study design for separating genetic from environmental causes of familial clustering. This nationwide study aimed to separate the biological (genetic) and familial environmental contribution to the familial transmission of IBS. Methods: We performed a family study for Swedish-born adoptees born from 1951 until 1995, and their biological and adoptive parents...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29104757/effect-of-nalfurafine-hydrochloride-in-patients-with-chronic-liver-disease-with-refractory-pruritus-on-sleep-disorders-a-study-protocol-for-single-arm-prospective-interventional-study
#18
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction: Chronic liver disease (CLD)-related pruritus manifests as cholestasis symptoms, which can cause severe itches in the whole body and significantly decrease quality of daily activities and sleep. The actigram, which documents movement by means of an accelerometer, has been demonstrated to be useful for assessing sleep quality. Nalfurafine hydrochloride, which is a selective κ-opioid receptor agonist, exerts its antipruritic efficacies through a novel mechanism. We aimed to prospectively examine the effect of nalfurafine hydrochloride on sleep quality for patients with CLD with pruritus utilising actigram...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29018541/results-from-a-retrospective-analysis-of-colonoscopies-for-inflammatory-bowel-disease-and-colorectal-cancer-in-a-lebanese-tertiary-care-centre
#19
Toufic Saber, Khalil Bedran, Fatima Ghandour, Mansour El Khoury, Roula Bou Khalil, Said Farhat
BACKGROUND AND AIMS: Inflammatory bowel diseases (IBDs) and colorectal cancer have an increased impact on the Lebanese population's morbidity and mortality. This study evaluated the situation of IBD and colorectal cancer at a tertiary hospital centre in Lebanon. METHODS: 1007 patients underwent colonoscopy over a period of 12 months by qualified physicians. 91 patients were excluded from the study. Biopsy results were divided into normal versus abnormal colonic tissue...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29018540/efficacy-of-individualised-diets-in-patients-with-irritable-bowel-syndrome-a-randomised-controlled-trial
#20
Ather Ali, Theresa R Weiss, Douglas McKee, Alisa Scherban, Sumiya Khan, Maxine R Fields, Damian Apollo, Wajahat Z Mehal
BACKGROUND: Patients with irritable bowel syndrome (IBS) are often placed on diets guided by food intolerance assays, although these have not been validated. We assessed the effects of individualised diets in patients with IBS guided by a leucocyte activation test. METHODS: This is a parallel-group, double-blind, randomised controlled trial of 58 adults with IBS seen at an academic health centre in Northeast USA. Peripheral venous blood was analysed using a leucocyte activation test; individual foods were reported to produce positive or negative results...
2017: BMJ Open Gastroenterology
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