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BMJ Open Gastroenterology

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https://www.readbyqxmd.com/read/28090335/top-down-infliximab-study-in-kids-with-crohn-s-disease-tiskids-an-international-multicentre-randomised-controlled-trial
#1
M A Cozijnsen, M van Pieterson, J N Samsom, J C Escher, L de Ridder
INTRODUCTION: Crohn's disease (CD) is a chronic inflammatory disease predominantly affecting the gastrointestinal tract. CD usually requires lifelong medication and is accompanied by severe complications, such as fistulae and strictures, resulting in surgery. Infliximab (IFX) is very effective for treating paediatric patients with CD, but is currently only registered for therapy refractory patients-the so-called step-up strategy. We hypothesise that using IFX first-line, that is, top-down, will give more mucosal healing, fewer relapses, less complications, need for surgery and hospitalisation...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28074151/clinical-and-ph-study-characteristics-in-reflux-patients-with-and-without-ineffective-oesophageal-motility-iem
#2
George Triadafilopoulos, Apurva Tandon, Katerina P Shetler, John Clarke
BACKGROUND: The aetiology and clinical impact of ineffective oesophageal motility (IEM) remain poorly understood, but the condition is thought to worsen supine gastro-oesophageal acid reflux (GERD). AIMS: In this retrospective cohort analysis of symptomatic patients with abnormal oesophageal acid exposure, we sought to determine any clinical or functional characteristics that would distinguish those with normal peristalsis from those with IEM, defined using the Chicago classification...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28074150/colorectal-cancer-mortality-10%C3%A2-years-after-a-single-round-of-guaiac-faecal-occult-blood-test-gfobt-screening-experiences-from-a-danish-screening-cohort
#3
Andreas Bjerrum, Ole Andersen, Anders Fischer, Jan Lindebjerg, Elsebeth Lynge
BACKGROUND: In Denmark, colorectal cancer (CRC) is the third most frequent cancer. Randomised trials have shown that guaiac faecal occult blood test (gFOBT) screening can reduce CRC mortality, but a recent large randomised study from Finland did not find any effect. A feasibility study was carried out in Denmark in 2005-2006 where residents aged 50-74 years in 2 Danish counties were invited once to participate in gFOBT screening. We used the unique Danish registers to assess the impact of gFOBT screening in this group on CRC incidence and mortality...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28074149/non-selective-%C3%AE-blockers-in-advanced-cirrhosis-a-critical-review-of-the-effects-on-overall-survival-and-renal-function
#4
Sara Blasco-Algora, José Masegosa-Ataz, Sonia Alonso, Maria-Luisa Gutiérrez, Conrado Fernández-Rodriguez
INTRODUCTION: Non-selective β-blockers (NSBBs) are widely prescribed in patients with cirrhosis for primary and secondary prophylaxis of bleeding oesophageal varices. Furthermore, it has been suggested that the clinical benefits of NSBBs may extend beyond their haemodynamic effects. Recently, a potentially harmful effect has been described in patients with refractory ascites or spontaneous bacterial peritonitis. METHODOLOGY: A comprehensive literature search on β-blockers and cirrhosis survival using the electronic databases PubMed/MEDLINE, AMED, CINAHL and the Cochrane Central Register of Controlled Trials...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27957337/national-complicated-acute-diverticulitis-cads-study-a-protocol-for-a-prospective-observational-scoping-study-for-acute-diverticulitis
#5
Shafaque Shaikh
BACKGROUND: Diverticular disease is a widely prevalent disease in western society, and acute diverticulitis is a common acute surgical presentation. However, there is a lack of level 1 evidence addressing the multifaceted presentations associated with acute diverticulitis. There is also a lack of robust epidemiological data that could be used to meaningfully inform randomised controlled trials. The National CADS project aims to generate baseline data for a cohort of patients managed for clinically suspected acute diverticulitis and evaluate the impact of variability in the management approach on patient outcomes in the short (3 months) and long (2 years) term...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27933204/risk-factors-for-developing-colorectal-cancer-in-japanese-patients-with-ulcerative-colitis-a-retrospective-observational-study-capital-cohort-and-practice-for-ibd-total-management-in-kyoto-shiga-links-study-i
#6
Takuya Yoshino, Hiroshi Nakase, Tomohisa Takagi, Shigeki Bamba, Yusuke Okuyama, Takuji Kawamura, Teruki Oki, Hirozumi Obata, Chiharu Kawanami, Shinji Katsushima, Toshihiro Kusaka, Tomoyuki Tsujikawa, Yuji Naito, Akira Andoh, Takafumi Kogawa
BACKGROUND AND AIMS: Patients with ulcerative colitis (UC) are at risk for developing colorectal cancer (CRC), despite the development of new therapeutic agents. Stratification of the individual UC-patient's risk would be helpful to validate the risk factors for CRC. The aim of this study was to evaluate the risk factors for the development of CRC in a large cohort of patients with UC. METHODS: Data were obtained from 12 hospitals in the Kyoto-Shiga region during 2003-2013...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27933203/maternal-inflammatory-bowel-disease-and-hypospadias-in-male-offspring-a-population-based-study-in-denmark
#7
Ane Birgitte Telén Andersen, Vera Ehrenstein, Rune Erichsen, Trine Frøslev, Henrik Toft Sørensen
BACKGROUND: The occurrence of inflammatory bowel disease (IBD) and hypospadias has been concurrently increasing, possibly through shared environmental risk factors such as endocrine disrupting compounds. Also, maternal IBD may disturb the normal development of the fetal reproductive tract. However, whether maternal IBD increases the risk of hypospadias in male offspring is unknown. We compared hypospadias risk in sons of mothers with and without IBD. METHODS: We used Danish nationwide population-based registries to conduct a longitudinal prevalence study including all live-born boys from 1979 through 2009...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27933202/screening-and-management-of-viral-hepatitis-and-hepatocellular-carcinoma-in-mongolia-results-from-a-survey-of-mongolian-physicians-from-all-major-provinces-of-mongolia
#8
Yoona A Kim, Jacqueline Estevez, An Le, Dennis Israelski, Oidov Baatarkhuu, Tserenchimed Sarantuya, Sonom Narantsetseg, Pagbajabyn Nymadawa, Richard H Le, Man-Fung Yuen, Geoffrey Dusheiko, Mario Rizzetto, Mindie H Nguyen
BACKGROUND: According to Globocan, Mongolia has the highest worldwide hepatocellular carcinoma (HCC) incidence (78.1/100 000, 3.5× higher than China). AIMS AND METHODS: We conducted an anonymous survey of physicians from major provinces who attended an educational liver symposium, analysing their demography, practice, knowledge, perceptions and proposed solutions. Multivariate logistic regression was used to estimate OR relating demography and practice factors with higher provider knowledge and improvement...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27933201/association-between-metabolic-syndrome-and-liver-histology-among-nafld-patients-without-diabetes
#9
Pushpjeet Kanwar, James E Nelson, Katherine Yates, David E Kleiner, Aynur Unalp-Arida, Kris V Kowdley
BACKGROUND: Metabolic syndrome (MetS) and obesity are associated with non-alcoholic fatty liver disease (NAFLD). The aim of this observational study was to examine the relationship of MetS and a diagnosis of non-alcoholic steatohepatitis (NASH) in patients without diabetes in the NASH Clinical Research Network (CRN). METHODS: Clinical, demographic, histological, laboratory and anthropometric data were collected on 356 adult patients without diabetes with NAFLD. Obesity was defined as body mass index ≥30...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27843572/utility-of-high-resolution-anorectal-manometry-and-wireless-motility-capsule-in-the-evaluation-of-patients-with-parkinson-s-disease-and-chronic-constipation
#10
Andrew Su, Rita Gandhy, Carrolee Barlow, George Triadafilopoulos
BACKGROUND: The aetiology of constipation in Parkinson's disease remains poorly understood. Defaecatory dyssynergia, anal sphincter spasticity and slow transit constipation may, individually or collectively, play a role. AIMS: In this retrospective cohort analysis of patients with Parkinson's disease and chronic constipation, we determined the utility of high-resolution anorectal manometry, balloon expulsion and wireless motility capsule testing in defining the underlying aetiology for constipation...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27843571/cachexia-in-cancer-what-is-in-the-definition
#11
Greetje Vanhoutte, Mick van de Wiel, Kristin Wouters, Michaël Sels, Linda Bartolomeeussen, Sven De Keersmaecker, Caroline Verschueren, Veronique De Vroey, Annemieke De Wilde, Elke Smits, Kin Jip Cheung, Liesbeth De Clerck, Petra Aerts, Didier Baert, Caroline Vandoninck, Sofie Kindt, Sofie Schelfhaut, Marc Vankerkhoven, Annelies Troch, Lore Ceulemans, Hanne Vandenbergh, Sven Leys, Tim Rondou, Elke Dewitte, Kristel Maes, Patrick Pauwels, Benedicte De Winter, Luc Van Gaal, Dirk Ysebaert, Marc Peeters
OBJECTIVE: This study aimed to provide evidence-based results on differences in overall survival (OS) rate to guide the diagnosis of cancer cachexia. DESIGN: Data collection and clinical assessment was performed every 3 months (5 visits): baseline data, muscle strength, nutritional and psychosocial status. 2 definitions on cachexia using different diagnostic criteria were applied for the same patient population. Fearon et al's definition is based on weight loss, body mass index (BMI) and sarcopenia...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27752338/management-of-hepatitis-c-genotype-4-in-the-directly-acting-antivirals-era
#12
Emma Hathorn, Ahmed M Elsharkawy
Genotype 4 chronic hepatitis C (G4 HCV) accounts for 13% of worldwide HCV infections; with 10 million people infected with the virus across the world. Up to the end of 2013, the only treatment option for G4 HCV was treatment with pegylated interferon and ribavirin for 24-48 weeks. Since late 2013, treatment of G4 HCV has been transformed by the licensing of many directly acting antiviral agents (DAA). It is an exciting time to be involved in the management of HCV generally and G4 particularly. Interferon-free DAA regimens are now a reality for G4 HCV...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27752337/gastric-microbiota-in-the-functional-dyspepsia-patients-treated-with-probiotic-yogurt
#13
Hirohiko Nakae, Ayumi Tsuda, Takashi Matsuoka, Tetsuya Mine, Yasuhiro Koga
OBJECTIVE: To investigate the structure of the gastric microbiota in functional dyspepsia (FD) and its role in the pathophysiology. DESIGN: We compared the basic physiological properties of the gastric fluid (GF) and the structure of the microbiota in the GF of 44 healthy control (HC) participants and 44 patients with FD. We then treated the patients with FD with a yogurt containing a probiotic strain of Lactobacillus gasseri OLL2716 (LG21 yogurt) and investigated the effects on the bacteriological parameters and symptoms to examine the relationship between them...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27648298/utility-of-wireless-motility-capsule-and-lactulose-breath-testing-in-the-evaluation-of-patients-with-chronic-functional-bloating
#14
George Triadafilopoulos
BACKGROUND: The precise aetiology of chronic bloating remains poorly understood and underlying gastroparesis, small bowel bacterial overgrowth and colonic inertia may, individually or collectively, play a role. AIMS: In this retrospective cohort analysis of symptomatic patients with chronic persistent bloating, we determined the clinical utility of wireless motility capsule and lactulose breath test in further defining the underlying aetiology for functional bloating...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27648297/assessment-of-health-utilities-and-quality-of-life-in-patients-with-non-alcoholic-fatty-liver-disease
#15
Mehmet Sayiner, Maria Stepanova, Huong Pham, Bashir Noor, Mercedes Walters, Zobair M Younossi
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease associated with increased liver-related mortality. Additionally, NAFLD could potentially impair health-related quality of life. Although an approved treatment for NAFLD does not exist, a number of new drugs for treatment of NAFLD are being developed. As the efficacy and safety of these regimens are being established, their cost-effectiveness, which requires the use of quality of life metrics and health utility scores to quality-adjusted outcomes, must also be assessed...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27648296/usefulness-of-sulfasalazine-for-patients-with-refractory-ulcerative-colits
#16
Takuya Yoshino, Makoto Sono, Shujiro Yazumi
BACKGROUND: Patients with refractory-ulcerative colitis (UC) require therapy escalation. Sulfasalazine (SASP) could deliver a high concentration of 5-aminosalicylic acid to the colon. The usefulness of SASP for refractory-UC patients, however, is unclear. AIM: The aim was to evaluate the usefulness of SASP for refractory-UC patients. METHOD: We retrospectively analysed 36 (11.4%) of 316 patients with refractory-UC who had been treated with SASP...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27648295/correction-percutaneous-endoscopic-transgastric-jejunostomy-peg-j-a-retrospective-analysis-on-its-utility-in-maintaining-enteral-nutrition-after-unsuccessful-gastric-feeding
#17
(no author information available yet)
[This corrects the article DOI: 10.1136/bmjgast-2016-000098.].
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27648294/phase-ii-study-of-neo-adjuvant-chemotherapy-for-locally-advanced-gastric-cancer
#18
Alex Yuang-Chi Chang, Kian Fong Foo, Wen-Hsin Koo, Simon Ong, Jimmy So, Daniel Tan, Khong Hee Lim
BACKGROUND: Neoadjuvant chemotherapy improves survival of locally advanced gastric cancer patients. However, benefit is limited and the best regimen remains controversial. OBJECTIVES: Our primary objective of this prospective, multicenter phase 2 study was to evaluate the pathological complete response rate (PCR) with 2 cycles of docetaxel and capecitabine. METHODS: To be eligible, patients had to have histologically documented gastric cancer, a ECOG performance status 0 or 1, T3or4 Nany M0 staging after oesophagogastroduodenoscopy (OGD), endoscopic ultrasound (EUS), CT scan of thorax and abdomen, and negative laparoscopic examination and peritoneal washing...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27547443/randomised-clinical-study-comparing-the-effectiveness-and-physiological-effects-of-hypertonic-and-isotonic-polyethylene-glycol-solutions-for-bowel-cleansing
#19
Hiro-O Yamano, Hiro-O Matsushita, Kenjiro Yoshikawa, Ryo Takagi, Eiji Harada, Yoshihito Tanaka, Michiko Nakaoka, Ryogo Himori, Yuko Yoshida, Kentarou Satou, Yasushi Imai
OBJECTIVES: Bowel cleansing is necessary before colonoscopy, but is a burden to patients because of the long cleansing time and large dose volume. A low-volume (2 L) hypertonic polyethylene glycol-ascorbic acid solution (PEG-Asc) has been introduced, but its possible dehydration effects have not been quantitatively studied. We compared the efficacy and safety including the dehydration risk between hypertonic PEG-Asc and isotonic PEG regimens. DESIGN: This was an observer-blinded randomised study...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27547442/gut-microbiota-associated-with-hiv-infection-is-significantly-enriched-in-bacteria-tolerant-to-oxygen
#20
Grégory Dubourg, Jean-Christophe Lagier, Sophie Hüe, Mathieu Surenaud, Dipankar Bachar, Catherine Robert, Caroline Michelle, Isabelle Ravaux, Saadia Mokhtari, Matthieu Million, Andreas Stein, Philippe Brouqui, Yves Levy, Didier Raoult
OBJECTIVES: Gut microbiota modifications occurring during HIV infection have recently been associated with inflammation and microbial translocation. However, discrepancies between studies justified a comprehensive analysis performed on a large sample size. DESIGN AND METHODS: In a case-control study, next-generation sequencing of the 16S rRNA gene was applied to the faecal microbiota of 31 HIV-infected patients, of whom 18 were treated with antiretroviral treatment (ART), compared with 27 healthy controls...
2016: BMJ Open Gastroenterology
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