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Iranian Journal of Pathology

Sora Yasri, Viroj Wiwanitkit
No abstract text is available yet for this article.
2016: Iranian Journal of Pathology
Beuy Joob, Viroj Wiwanitkit
No abstract text is available yet for this article.
2016: Iranian Journal of Pathology
Moeinadin Safavi, Shahriar Dabiri
No abstract text is available yet for this article.
2016: Iranian Journal of Pathology
David S Rosero, Ramiro Alvarez, Paula Gambó, María Alastuey, Alberto Valero, Nerea Torrecilla, A Belén Roche, Sara Simón
Acinic cell carcinoma arising in salivary glands is a rare tumor, accounting for 2% to 5% of the primary neoplasms of the parotid gland. When these tumors are well-differentiated, the neoplasia has innocuous aspect, due to the similarity to normal parotid tissue. This makes the diagnosis difficult. Initially the malignancy of this tumor was uncertain; however, recent studies have declared it as malignant. The female / male ratio is 3:2. The nodule usually presents as solitary and well defined shape. Several authors have used different terms to describe histomorphological patterns of these tumors...
2016: Iranian Journal of Pathology
Tamgadge Avinash, Tamgadge Sandhya, Shashibhushan Dodal, Mayura Chande, Treville Pereira
Neurilemmomas are benign tumors of peripheral nerve sheath Schwann cells. One of the variants of neurilemmoma is the ancient type of neurilemmoma characterized by degenerative features such as cystic degeneration, calcification, hemorrhage and hyalinization which could be easily misdiagnosed. Their occurrence in oral cavity is extremely rare and intraosseous type occurring in maxilla is exceedingly rare with very few cases being published in literature. A 38 year old male patient reported with a chief complaint of swelling over the left cheek and left upper back region since 10 months...
2016: Iranian Journal of Pathology
Bushra Siddiqui, Shahbaz Habib Faridi, Veena Maheshwari, Mohammad Aslam, Kafeel Akhter
Granulomatous response in association with breast cancer and within the cancer draining lymph nodes is an extremely rare phenomenon. Granulomatous inflammation is an immune response commonly seen against infectious agents and certain non-neoplastic conditions. The etiopathogenesis of granulomas associated with malignancies is not clear but it may be because of an immunologic reaction to tumour antigens. We hereby report a 50-yr-old postmenopausal female presented to Surgical Outpatient Department, Aligarh Muslim University, India, with complaints of lump and pain in her left breast for 6 months...
2016: Iranian Journal of Pathology
Debjani Mallick, Aniruna Aniruna, Sonia Gon, Gayatri Ghosh
Malignant papillary neoplasms of the breast comprise a number of microscopically distinct lesions, where apocrine metaplasia is commonly found in papillomas compared to other papillary lesions including papillary carcinomas. However, association of apocrine metaplasia in papilloma with Ductal Carcinoma in Situ (DCIS) is not very well defined. The lesions with apocrine metaplasia are not only difficult to categories, but also there is controversy regarding their relative risk of subsequent carcinoma development...
2016: Iranian Journal of Pathology
Manisha Sharma, Manas Madan, Mridu Manjari, Harleen Kaur
Chondrosarcoma is a mesenchymal tumor composed of tumor cells producing cartilage. It is more common in older age and often affects the axial skeleton. We report a rare case of chondrosarcoma mimicking a sellar and suprasellar mass with parasellar extension. A 40 yr woman presented with decreasing visual acuity and headache. Magnetic resonance (MR) image revealed a cystic sellar and suprasellar mass with parasellar extension showing mild enhancing solid component. It favored the diagnosis of craniopharyngioma...
2016: Iranian Journal of Pathology
Dian Cahyanti, Lisnawati Rachmadi, Vally Wulani, Marlinda Adham
BACKGROUND: Overexpression of Rad51 protein in many tumor cells has been proven to increase radioresistance and can be related to the resistance of chemosensitivity of tumor cells. This preliminary study was conducted to determine the relationship between the Rad51 expression level in nasopharyngeal carcinoma and the response of the treatment based on the measurement of the tumor reduction. METHODS: Thirteen cases of the NPCs were analyzed. The expression levels of the Rad51 were examined from the pretreatment biopsies...
2016: Iranian Journal of Pathology
Vikram Narang HarsimranKaur, Pavneet Kaur Selhi, Neena Sood, Aminder Singh
BACKGROUND: Quality assurance in the hematology laboratory is a must to ensure laboratory users of reliable test results with high degree of precision and accuracy. Even after so many advances in hematology laboratory practice, pre-analytical errors remain a challenge for practicing pathologists. This study was undertaken with an objective to evaluate the types and frequency of preanalytical errors in hematology laboratory of our center. METHODS: All the samples received in the Hematology Laboratory of Dayanand Medical College and Hospital, Ludhiana, India over a period of one year (July 2013-July 2014) were included in the study and preanalytical variables like clotted samples, quantity not sufficient, wrong sample, without label, wrong label were studied...
2016: Iranian Journal of Pathology
Sharareh Mohammad Hasani, Reza Mirnejad, Jafar Amani, Mohamad Javad Vafadar
BACKGROUND: Rapid diagnosis and differentiation of Brucella is of high importance due to the side effects of antibiotics for the treatment of brucellosis. This study aimed to identify and compare PCR-ELISA as a more accurate diagnositc test with other common molecular and serological tests. METHODS: In this experimental and sectional study, during March 2014 to Sep 2015, 52 blood samples of suspected patients with clinical symptoms of brucellosis were evaluated in medical centers all over Iran with serum titers higher than 1:80...
2016: Iranian Journal of Pathology
Gholamreza Irajian, Mehri Sharifi, Shiva Mirkalantari, Reza Mirnejad, Mohammad Reza Jalali Nadoushan, Nafiseh Ghorbanpour
BACKGROUND: In most cases, prostatitis can be caused by a bacterial agent such as Ureaplasma urealyticum. Considering to the cumbersome of the culture method for the detection of Ureaplasma species in clinical samples such as prostate; PCR method that is faster and more appropriate than the cultivation methods, can be utilized for the detection of U. urealyticum and U. parvum. PCR-RFLP method can differentiate both biovars and assist in studies of the clinical diagnosis, epidemiology and pathology of this species in human...
2016: Iranian Journal of Pathology
B M Warpe, A V Shrikhande, S V Poflee
BACKGROUND: Until now, trimodal distribution of HbS has been seen by six different studies in the world when associated with alpha-thalassemia with confirmation by corresponding alpha-genotyping studies. The RBC indices reduce as alpha-globin genes reduce in sickle cell trait (SCT) patients, which decreases the extent of intra-vascular sickling and thus betters the clinical course of the patients. This is a pioneer study conducted on Central Indian poor population to use the already proven six studies to screen associated alpha-thalassemia in SCT patients thus, circumventing the much costlier alpha-genotyping studies...
2016: Iranian Journal of Pathology
Seyed Ali Asghar Fakhrmousavi, Azar Hadadi, Seyed Hamed Hosseini, Maryam Rahbar, Reza Hamidian, Amitis Ramezani, Gholamreza Pourmand, Effat Razeghi
BACKGROUND: Hepatitis B virus potentially accelerates graft rejection and mortality in renal transplantation population. Vaccination of graft candidates without prior immunization against HBV seems essential before transplantation but some candidates of transplantation have not received HBV vaccine at the time of receiving graft. We aimed to evaluate immunogenicity of an enhanced regimen (4 doses of double-strength intramuscular shots) after kidney transplantation in candidates without history of prior HBV vaccination...
2016: Iranian Journal of Pathology
Maliheh Khoddami, Yassaman Khademi, Maryam Kazemi Aghdam, Haleh Soltanghoraee
BACKGROUND: Presence of discordance between the Gleason score on needle biopsy and the score of radical prostatectomy specimen is common and universal. In this study, we determined the accuracy of Gleason grading of biopsies in predicting histological grading of radical prostatectomy specimens and the degree of overgrading and undergrading of prostatic adenocarcinoma in our center, which is one of the referral centers in Tehran. METHODS: In this retrospective study, we analyzed the results of prostate needle biopsies and subsequent prostatectomies diagnosed at the Pathobiology Laboratory Center, Tehran, Iran in 45 patients between 2002 and 2013...
2016: Iranian Journal of Pathology
Samira Rashidian, Roghayeh Teimourpour, Zahra Meshkat
BACKGROUND: Tuberculosis (TB) remains as a major cause of death. Construction of a new vaccine against tuberculosis is an effective way to control it. Several vaccines against this disease have been developed. The aim of the present study was to cloning of tb10.4 gene in pcDNA3.1(+) plasmid and evaluation of its expression in eukaryotic cells. METHODS: Firstly, tb10.4 fragment was amplified by PCR and the PCR product was digested with restriction enzymes. Next, it was cloned into pcDNA3...
2016: Iranian Journal of Pathology
Shahriar Dabiri, Mohammadmehdi Moeini Aghtaei, Jahanbano Shahryari, Manzume Shamis Meymandi, Sahar Amirpour-Rostami, Reza Foutohi Ardekani
BACKGROUND: The breast cancer is the most prevalent cancer among women, on the other hand absence of myoepithelial cells play a pivotal role in pathogenesis of this cancer. Thus we aimed to investigate the possible abilities of the molecular assay technique to find a relationship between mammary serine protease inhibitor (Maspin) gene expression possibly secreted by myoepithelial cells, grade of breast cancer and other prognostics factors (ER, PR, and c-erb-B2). METHODS: Paraffin embedded blocks of 31 breast cancer patients together with two normal breast tissues were used for IHC staining and Maspin gene RNA detection uses the real-time PCR method...
2016: Iranian Journal of Pathology
Parya Bameni Moghaddam, Fatemeh Mahjoub, Amirhossein Emami, Alireza Abdollahi
BACKGROUND: Automatic Cell Counter devises make the CBC differential very easy and delivering the results in few second. However, the problem with this device is facing a flag requires a time-consuming microscopic review of the specimen which causes unacceptable wait times for patient as well as costs for laboratories. In this study, we calculated the validity of WBC diff flags in Sysmex XT-1800i. In addition, we verified the correlation between manual and automated samples. METHODS: Overall, 1095 flagged samples were selected in the period of 6 weeks (Imam Hospital complex, Tehran Iran, 2014)...
2016: Iranian Journal of Pathology
Alireza Abdollahi, Hana Saffar
It is estimated that the number of HIV infected children globally has increased from 1.6 million in 2001 to 3.3 million in 2012. The number of children below 15 years of age living with HIV has increased worldwide. Published data from recent studies confirmed dramatic survival benefit for infants started anti-retroviral therapy (ART) as early as possible after diagnosis of HI. Early confirmation of HIV diagnosis is required in order to identify infants who need immediate ART. WHO has designed recommendations to improve programs for both early diagnoses of HIV infection and considering ART whenever indicated? It is strongly recommended that HIV virologocal assays for diagnosis of HIV have sensitivity of at least 95% and ideally greater than 98% and specificity of 98% or more under standardized and validated conditions...
2016: Iranian Journal of Pathology
Moeinadin Safavi, Shahriar Dabiri, Nahid Monsefi
No abstract text is available yet for this article.
2016: Iranian Journal of Pathology
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