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Iranian Journal of Pathology

Fatemeh Khatami, Seyed Mohammad Tavangar
Pheochromocytomas (PCCs) are rare neuroendocrine tumors. The current diagnostic tools are based on biochemistry and histopathology results, but heterogeneity of diagnostic markers, signs and symptoms of PCCs bring a lot of difficulties for these two current methods. Unfortunately, microscopic understanding of PCCs is not adequate for its confident prognosis and management. There are data linking specific genotypes of PCCs tumors to specific locations, typical biochemical phenotypes or future clinical behaviors...
2017: Iranian Journal of Pathology
Martina Montagnana, Elisa Danese, Gabriel Lima-Oliveira, Gian Luca Salvagno, Giuseppe Lippi
Beside the well-established impact on decreasing the risk of cardiovascular diseases (1), recent attention has been paid to the relationship between cocoa-containing foods and the immune system (2), showing that dark chocolate consumption enhances the systemic defense against bacterial (3) and viral (4) infections. Hence, the current study aimed at investigating the acute effect of dark chocolate intake on peripheral blood leukocytes.
2017: Iranian Journal of Pathology
Subrata Pal, Kingshuk Bose, Prabhat Ch Mondal, Srabani Chakrabarti, Mrinal Sikder
Placental mesenchymal dysplasia (PMD) is a rare benign placental abnormality. It is characterized by hydropic degeneration of stem villi, placentomegaly, and increased maternal serum alpha-fetoprotein (AFP). It can be associated with different congenital abnormalities, karyotype abnormalities, and feto-maternal morbidities. It is difficult to differentiate PMDfrom partial mole, complete mole with twin pregnancy in ultrasound, and in macroscopic examination. The current paper presentsa rare case of placental mesenchymal dysplasia in a young primigravida mother who delivered a normal fetus withnormal karyotype...
2017: Iranian Journal of Pathology
Rupam Sinha, Soumyabrata Sarkar, Tanya Khaitan, Deepsikha Ramani
Gorham's disease is a rare and atypical disorder epitomized by progressive osteolysis of bone with eventual total disappearance of bone. The etiology is poorly understood with variable clinical presentation. Most times it is initially misdiagnosed as temporomandibular joint dysfunction, periodontal disease or odontogenic tumors clinically and radiographically in routine dental practice. Radiographic examination, such as Cone Beam Computerized Tomography (CBCT) play a vital role in diagnosing such disorder resulting in disappearance of the involved bone entirely, which is a definitive distinguishing feature of this condition...
2017: Iranian Journal of Pathology
Chandan Kumar, Pragya Jain, Neelam Wadhwa, Preeti Diwaker, Khan Nirupma Panikar
Mucormycosis is a rare but highly invasive opportunistic fungal infection. Gastrointestinal disease although uncommon is highly fatal. We report a case of jejunal mucormycosis in a 24 year old undernourished female with preceding surgical intervention for acute intestinal obstruction of tubercular etiology. On 8th post-operative day, she developed oozing from suture line, prompting exploratory laparotomy, bowel resection, jejunostomy and ileal mucus fistula. Resected bowel showed one perforation and several areas of impending perforations...
2017: Iranian Journal of Pathology
Indranil Chakrabarti, Priyanka Agarwala, Pranati Bera, Sankarsan Bhaduri
Background: Phyllodes tumors (PTs) are uncommon biphasic fibroepithelial neoplasms of the breast occurring in elderly females with a peak incidence between 45 and 49 years. Depending on various histological criteria, they are subdivided into benign, borderline, and malignant forms. Metaplastic changes occur, but are quite infrequent and cystic squamous metaplasia is very rare among the observed metaplastic changes in PT. Case: The current paper presents the case of a 41-year-old female with a progressively enlarging swelling in the left breast...
2017: Iranian Journal of Pathology
Alireza Sadeghipour, Navid Abdi, Pegah Babaheidarian
Background: Tuberous sclerosis (TSC) is inherited as an autosomal dominant disease, characterized by skin lesion and tubers in vital organs, especially brain in three categories including subependymal nodules, cortical tubers and subependymal giant cell astrocytoma. Subependymal giant cell astrocytoma (SEGA) is an indolent neoplasm which usually arises at the cauda thalamic groove near foramen monro, although it occurs usually in the clinical settings of TSC, a few number of SEGA has been reported without such history...
2017: Iranian Journal of Pathology
Ivonne Montes-Mojarro, Javier Baquera-Heredia, Juan Felipe Sanchez-Marle, Carlos Ortiz-Hidalgo
The solitary fibrous tumors (SFT) are rare tumors in the head and neck region and there have been only 5 cases reported in the literature in the soft palate. The current paper presents a unique case of a 62-year-old male with TFS arising in the soft palate. The tumor was highly cellular, composed of bland looking haphazardly arranged spindle cells. The signal transducer and activator of transcription (STAT)-6 and nuclear β-catenin were reactive by immunohistochemistry (IHC). The current case highlights the importance of the STAT-6 and the β-catenin as IHC markers to make a differential diagnosis with other entities...
2017: Iranian Journal of Pathology
Krishnendu Mondal, Rupali Mandal
Background: Carcinoid tumors usually originate from the enterochromaffin cells located in gastrointestinal tract and bronchopulmonary system. They may rarely arise in the urinary bladder, where this can be eventually miscued as any other commoner bladder neoplasms. The current study was conducted to connote an uncommon clinicopathological presentation by a carcinoid tumor in the urinary bladder. Case: A 52-year-old male, who initially experienced obstructive urinary symptoms, underwent cystourethroscopy to remove a tumor in the urinary bladder...
2017: Iranian Journal of Pathology
Ramesh Omranipour, Habibollah Mahmoud Zadeh, Fershteh Ensani, Samira Yadegari, Seyed Rohollah Miri
Renal cell carcinoma (RCC) metastasis to duodenum is very rare and only a few case reports are available in the literature. We here reported a patient with solitary duodenal metastasis presented with melena six years after right nephrectomy. The patient underwent upper gastrointestinal endoscopy showing ulcerative mass at the second portion of duodenum and biopsy of this mass was consistent with metastatic RCC. Metastasis work up did not find any other site of malignancy, thus Whipple's operation (Pancreaticoduodenectomy) was performed...
2017: Iranian Journal of Pathology
Hasan Jalaeikhoo, Seyed Mohammad Hossein Kashfi, Pedram Azimzadeh, Ahmad Narimani, Katayon Gouhari Moghadam, Mohsen Rajaienejad, Mehdi Ariana, Manouchehr Keyhani
Background & objective: Pancytopenia is the reduction in the number of all 3 major cellular elements of blood and leads to anemia, leukopenia, and thrombocytopenia. A wide variety of etiologies result in pancytopenia including leukemia, aplastic anemia, and megaloblastic anemia. The current study identified the different etiologies of pancytopenia based on bone marrow examination in Iranian patients with pancytopenia. Methods: A total of 683 cases of pancytopenia with various etiologies were selected for this retrospective study...
2017: Iranian Journal of Pathology
Nayere Askari, Tooba Ghazanfari, Mohammad Mehdi Naghizadeh, Athar Moin, Ali Khamesipour, Shahryar Pourfarzam, Zuhair Mohammad Hassan
Background & objective: Pruritus is the most frequent chronic dermal complication of sulfur mustard (SM), which negatively influences the quality of life. Exact pathophysiology of SM-induced itching is unknown. The current study aimed at evaluating the possible association between SM-induced itching and the serum levels of matrix metalloproteinase (MMP)-9 and their endogenous inhibitors, and serum levels of soluble forms of selectins (sL-, sP-, and sE-selectins) as adhesion molecules involved in the development of different inflammatory reactions...
2017: Iranian Journal of Pathology
Sina Rostami, Alireza Pasdar, Sina Gerayli, Hamed Hatami, Samaneh Sepahi, Fatemeh Nategh, Mojtaba Meshkat, Seyed Mousalreza Hoseini, Mitra Ahadi, Hamid Reza Sima, Hasan Vosughinia, Mohammad Reza Sarvghad, Abbas Esmaeelzade, Hosein Nomani, Homan Mosanan Mozafari, Fariba Rezai Talab, Mohammad Taghi Shakeri, Zahra Meshkat
No abstract text is available yet for this article.
2017: Iranian Journal of Pathology
Mahsa Ahadi, Afshin Moradi, Azadeh Rakhshan, Alireza Arefian, Mitra Rafizadeh, Hanieh Zham
Background and Objectives: Gliomas are the most prevalent subgroup of primary brain tumors with a relatively high mortality. However, oligodendrogliomas have a better prognosis compared to other subtypes due to their sensitivity to chemotherapy. Considering the low incidence and the resulting lack of information about oligodendrogliomas, particularly in Iran, this study aimed at assessing their basic characteristics. Methods: In this descriptive retrospective study, patients with definite diagnosis of oligodendroglioma were identified by reviewing the archives of pathology reports at the department of pathology of Shohada-e Tajrish Hospital during years 2008 to 2014...
2017: Iranian Journal of Pathology
Zeeba S Jairajpuri, Rekha Ghai, Sumita Saluja, Sujala Kapur, K T Bhowmik
Background & Objective: The current study aimed to perform an immunohistochemical analysis of patterns of apoptotic and cell proliferative related protein expression in different histological grades and immune phenotypes of malignant lymphomas and other lymphoproliferative disorders. Methods: This observational study was carried on 60lymph node biopsies of lymphoproliferative disorders. The biopsies were analyzed histologically and immunohistochemically. Results: A total of 60 lymph node biopsies were included in the study, of which 81...
2017: Iranian Journal of Pathology
Fatemeh Mashhadiabbas, Masoume Fayazi-Boroujeni
Background & objective: Changes in submucosal vascularization and inflammation, determined by immunohistochemistry staining, were shown to be correlated with the development of dysplasia and invasiveness of epithelial cells in premalignant and malignant lesions. This study evaluated changes in sections routinely stained with Hematoxylin and Eosin (H&E) in order to investigate vascular density and intensity of inflammatory cells infiltration during the progression of oral leukoplakia with mild dysplasia to Squamous Cell Carcinoma (SCC)...
2017: Iranian Journal of Pathology
Azadeh-Sadat Nazouri, Ommolbanin Asadpour, Shahriar Dabiri, Bahram Pourseyedi, Mohamad Reaza Lashkarizadeh, Hamid Zianalinejad
Background & objective: Breast cancer is the leading cause of cancer related death in females. Sphingosine kinase 1 (SPHK1) and its product sphingosine-1-phosphate (S1P) are the essential key regulator molecules in breast cancer through their ability to promote cell proliferation, angiogenesis, cell proliferation, and lymphagiogenesis. SPHK1 is overexpressed in multiple types of cancer including breast cancer and is associated with resistance to treatment. The current study aimed at investigating the expression of SPHK1 in estrogen and progesterone receptors (ER, PR) negative in comparison to ER, and PR positive breast cancer and their normal controls, and also finding the relationship between SPHK1 expression and high body index (BMI) in the selected groups with breast cancer...
2017: Iranian Journal of Pathology
Farhad Shahi, Razieh Alishahi, Hossein Pashaiefar, Isa Jahanzad, Naser Kamalian, Ardeshir Ghavamzadeh, Marjan Yaghmaie
Background & Objective: Soft tissue sarcomas (STS) constitute an uncommon and heterogeneous group of tumors of mesenchymal origin and various cytogenetic abnormalities ranging from distinct genomic rearrangements, such as chromosomal translocations and amplifications, to more intricate rearrangements involving multiple chromosomes. Fluorescence in situ hybridization (FISH) can be used to identify these chromosomal translocations and amplifications, and sub classify STS precisely. The current study aimed at investigating the usefulness of FISH, as a diagnostic ancillary aid, to detect cytogenetic abnormalities such as MDM2 (murine double minute 2 ) amplification and CHOP (C/EBP homologous protein) rearrangement in liposarcoma, as well as SYT (synaptotagmin ) rearrangement in synovial sarcoma...
2017: Iranian Journal of Pathology
Fereshteh Ensani, Ramesh Omranipour, Isa Jahanzad, Azadeh Jafari, Shima Nafarzadeh, Pouyan Aminishakib
Background &Objectives: Evaluation of estrogen receptor (ER), progesterone receptor (PR), and (human epidermal growth factor receptor-2) Her-2 on core needle biopsies (CNBs) is increasingly in use to diagnosis early breast cancer, but its concordance with surgical excision (SE) is not well documented. Methods: The study included 100 formalin fixed, paraffin-embedded specimens of invasive breast carcinoma archived in Pathology Department of Cancer Institute, Tehran, Iran, from 2011 to 2014...
2017: Iranian Journal of Pathology
Amir Hossein Jafarian, Masoumeh Gharib, Nema Mohammadian Roshan, Samaneh Sherafatnia, Abbas Ali Omidi, Sahar Bagheri
Background & objective: The histologic distinction of small cell from non-small cell lung carcinoma and correct identification of all subtype s of lung carcinoma are very important in treatment management. The main method for histologic classification of lung tumors is based on morphology. However, in small bronchoscopic biopsies in particular, distinction is very difficult upon morphology alone. The current study aimed at evaluating the utility of a panel of antibodies, consisting of thyroid transcription factor (TTF-1), P63, high molecular weight keratin [HMWK (34βE12)], cytokeratin (CK7), and cluster of differentiation (CD56) for accurate distinction of bronchogenic carcinomas...
2017: Iranian Journal of Pathology
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