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Iranian Journal of Pathology

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https://www.readbyqxmd.com/read/29731805/reporting-an-experience-improving-the-feulgen-staining-technique-for-better-visualizing-of-nucleus
#1
Noushin Jalayer Naderi
No abstract text is available yet for this article.
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731804/ectopic-thyroid-in-stomach-a-case-report
#2
Parvin Rajabi, Seyed-Mehdi Eftekhari, Elham Rouhani, Azar Baradaran
An ectopic thyroid is a form of thyroid dysgenesis in which an entire or parts of the thyroid gland may be located in another part of the body than what is the usual place. The most frequent location is the base of tongue. Although most cases are asymptomatic, symptoms related to tumor size and its relationship with surrounding tissues, hormonal dysfunction and seldom malignancy may also occur. Any disease affecting the thyroid gland may involve the ectopic thyroid, including malignancy.
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731803/ovarian-small-cell-carcinoma-a-rare-case-report-and-review-of-literature
#3
Savita Agarwal, Pinki Pandey, Megha Ralli, Shruti Singh
Ovarian small cell carcinoma is a rare and highly malignant tumor with poor prognosis. It usually presents in younger females with features of hypercalcemia. The exact histogenesis of the tumor is unclear and it may present as an undifferentiated tumor. In such cases, immunohistochemistry (IHC) plays an important role to confirm the diagnosis. Limited treatment options are available and mainly include radical surgery followed by adjuvant therapy in advanced stages. The current report was a rare case of small cell carcinoma of ovary presenting no symptoms of hypercalcemia diagnosed on histopathological examination and IHC findings...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731802/pseudopapillary-and-macrofollicular-microscopic-growth-patterns-in-an-advanced-stage-ovarian-dysgerminoma-a-case-report
#4
Fatemeh Nili, Niusha Nobari, Alireza Abdollahi
Dysgerminoma is one of the two most common types of ovarian germ cell tumors. Providing accurate pathologic diagnosis and treatment planning, the prognosis is good even in advanced stages. Pathologic diagnosis is generally straightforward. In microscopic examination, the usual known growth patterns in tumor cells are solid, trabecular, insular and rarely pseudoglandular. In this paper, we reported an advanced ovarian dysgerminoma with different microscopic patterns of growth, including pseudopapillary and macrofollicular structures, in an 18-year-old woman...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731801/sarcomatoid-carcinoma-of-renal-pelvis-involving-ureter-and-renal-parenchyma-with-heterologous-osteosarcomatous-differentiation-a-case-report-and-review-of-literature
#5
Bhavya P Mohan, P L Jayalakshmy, V Letha, Suresh Bhat
Sarcomatoid carcinoma is a highgrade rare malignant tumor with both epithelial and mesenchymal components. Sarcomatoid carcinoma in the upper urinary tract is very rare. We reported here a case of sarcomatoid carcinoma of renal pelvis with osteosarcomatous differentiation, with involvement of the ureter and renal parenchyma in a 68-year-old female. Histologically, predominant pleomorphic spindle cell sarcoma component with osteoid production and urothelial carcinoma component with in situ areas were identified...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731800/sinonasal-teratocarcinosarcoma-a-rare-tumour-not-so-rarely-misdiagnosed
#6
Jayalakshmy P Leelamma, Bhavya P Mohan, Aparna Srinivasan
Sinonasal teratocarcinosarcoma (STCS) is a rare, morphologically heterogeneous and highly aggressive tumour of ambiguous origin. It is characterized by the presence of benign and malignant epithelial, mesenchymal and neuroectodermal components. Because of their rarity and heterogeneity, these lesions are often misdiagnosed, leading to management difficulties. Adequate sampling with a high index of suspicion is needed to diagnose this rare tumour. We reported here a 48-year old man with right nasoethmoidal mass eroding the cribriform plate with intracranial extension...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731799/beware-of-bone-marrow-incidental-detection-and-primary-diagnosis-of-solid-tumours-in-bone-marrow-aspiration-and-biopsies-a-study-of-22-cases
#7
Ruchita Tyagi, Aminder Singh, Bhavna Garg, Neena Sood
Background & objective: Introduction: First detection of any solid tumour as metastatic deposits in bone marrow directs clinicians to start searching for the primary tumour. Detection of bone marrow metastasis determines the stage of the malignancy, prognosis, mode of treatment, chemotherapeutic response and follow-up in case of relapse. The aim of the current study was to analyse the clinico-haematological presentation and morphological pattern of infiltration of solid tumours detected first as metastatic deposits on bone marrow examination...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731798/prognostic-significance-of-reduction-in-ki67-index-after-neoadjuvant-chemotherapy-in-patients-with-breast-cancer-in-kerman-between-2009-and-2014
#8
Vahid Moazed, Elham Jafari, Behjat Kalantari Khandani, Ali Nemati, Alale Roozdar, Seyyed Amir Ben Razavi
Background and objective: Breast cancer is the most common malignancy among women. The Neoadjuvant chemotherapy is the treatment of choice for non-operable tumors. The Ki67 is a proliferation marker that can be used to predict the therapeutic response to chemotherapy and the patients' prognosis. Methods: This retrospective study was carried out on 55 consecutive patients with breast cancer referred to a Training Tertiary Healthcare Center in Kerman, Iran since 2009 to 2014...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731797/the-association-between-ocular-problems-and-serum-testosterone-prolactin-and-thyroglobulin-concentrations-in-delayed-phase-of-sulfur-mustard-exposure
#9
Hassan Ghasemi, Nayere Askari, Sakine Moaiedmohseni, Soghrat Faghihzadeh, Susan Kabudanian Ardestani, Elham Faghihzadeh, Tooba Ghazanfari
Background and objective: Aside from direct toxic effects, Sulfur Mustard (SM) induced serum hormone abnormalities may aggravate ocular complaints, including Ocular Surface Discomfort (OSD) (burning, itching, and redness), dry eye sensation, photophobia, blurred vision, foreign body sensation, and pain. The aim of the current study was to investigate the possible association of ocular complaints with serum hormone concentrations in chronic phase of Sulfur Mustard (SM) exposure. Methods: As a part of Sardasht Iran Cohort Study (SICS), 372 SM-exposed patients and 128 non-exposed participants were enrolled...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731796/development-of-multiplex-reverse-transcription-polymerase-chain-reaction-for-simultaneous-detection-of-influenza-a-b-and-adenoviruses
#10
Mohsen Nakhaie, Hoorieh Soleimanjahi, Hamid Reza Mollaie, Seyed Mohamad Ali Arabzadeh
Background and objective: Millions of people in developing countries lose their lives due to acute respiratory infections, such as Influenza A & B and Adeno viruses. Given the importance of rapid identification of the virus, in this study the researchers attempted to design a method that enables detection of influenza A, B, and adenoviruses, quickly and simultaneously. The Multiplex RT PCR method was the preferred method for the detection of influenza A, B, and adenoviruses in clinical specimens because it is rapid, sensitive, specific, and more cost-effective than alternative methods...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731795/expression-of-prostate-specific-membrane-antigen-psma-in-brain-glioma-and-its-correlation-with-tumor-grade
#11
Hiva Saffar, Maryam Noohi, Seyed Mohammad Tavangar, Hana Saffar, Sima Azimi
Background & Objective: Angiogenesis is an essential component of tumor growth. Expression of PSMA on the neo-vasculature of many solid tumors, including glioblastoma multi-form, has been determined. The pattern of expression suggests that PSMA may play a functional role in angiogenesis. Methods: expression of PSMA in different grades of brain glioma was evaluated by the immunohistochemistry method to determine the probable usefulness of anti-PSMA antibody as complementary target therapy in different grades of glioma...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731794/the-evaluation-of-diagnostic-and-predictive-values-of-helicobacter-pylori-stool-antigen-test-in-iranian-patients-with-dyspepsia
#12
Fahimeh Safarnezhad Tameshkel, Mohammad Hadi Karbalaie Niya, Zahedin Kheyri, Davood Azizi, Farzin Roozafzai, Samaneh Khorrami
Background and Objectives: Iran, as a developing country, is experiencing high burdens of Helicobacter pylori (Hp)-associated non-communicable diseases. Hp stool antigen test (HpSA) is widely used as an inexpensive and feasible noninvasive method to diagnose Hp infection, instead of invasive approaches. The current study aimed at evaluating the diagnostic and predictive values of HpSA test for Hp infection in Iranian patients with dyspepsia. Methods: The current cross sectional study was performed on 100 patients with dyspepsia...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731793/micronucleus-assay-in-exfoliated-buccal-epithelial-cells-using-liquid-based-cytology-preparations-in-building-construction-workers
#13
P Arul, Shetty Smitha, Suresh Masilamani, C Akshatha
Background and objective: Cytogenetic damage in exfoliated buccal epithelial cells due to environmental and occupational exposure is often monitored by micronucleus (MN) assay using liquid based cytology (LBC) preparations. This study was performed to evaluate MN in exfoliated buccal epithelial cells of building construction workers using LBC preparations. Methods: LBC preparations of exfoliated buccal epithelial cells from 100 subjects [50 building construction workers (cases) and 50 administrative staffs (controls)] was evaluated by May-Grunwald Giemsa, Hematoxylin and Eosin and Papanicolaou stains...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731792/immunohistochemical-characterization-of-normal-ovary-and-common-epithelial-ovarian-neoplasm-with-a-monoclonal-antibody-to-cytokeratin-and-vimentin
#14
Ankita Goel, Nandam Mohan Rao, Vissa Santhi, Syam Sundar Byna, Bhavana Grandhi, Jyothi Conjeevaram
Background & Objective: The common epithelial ovarian tumors are classified into serous, mucinous, clear cell, endometrioid, the Brenner, mixed, and undifferentiated types. Cytoskeleton intermediate filament composition of ovarian tissues indicates that the cytokeratin and vimentin are observed in ovarian surface epithelium along with the common ovarian epithelial tumors. The current study aimed at investigating the cytokeratin and vimentin expression in epithelial ovarian tumors to establish a diagnostic relevance...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731791/the-modulatory-effects-of-vitamin-d-on-the-expression-of-il-12-and-tgf-%C3%AE-in-the-spinal-cord-and-serum-of-mice-with-experimental-autoimmune-encephalomyelitis
#15
Rayhaneh Ahangar-Parvin, Marzieyeh Mohammadi-Kordkhayli, Sayyed Vahab Azizi, Maryam Nemati, Hossain Khorramdelazad, Zahra Taghipour, Zuhair Hassan, Sayyed Mohammad Moazzeni, Abdollah Jafarzadeh
Background & objective: The immunoregulatory effects of transforming growth factor (TGF)-βand interleukin-12 (IL-12) and immunomodulatory actions of vitamin D (VD) were reported in several studies. This study aims to evaluate VD effects on IL-12 and TGF-β expression in experimental autoimmune encephalomyelitis (EAE). Methods: EAE was induced in three groups of C57BL/6 mice by immunization with MOG and administered intra-peritoneally 200 ngVD, PBS or olive oil (OO) from day +3 to +30...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731790/prevalence-of-clinically-isolated-metallo-beta-lactamase-producing-pseudomonas-aeruginosa-coding-genes-and-possible-risk-factors-in-iran
#16
REVIEW
Abdolmajid Ghasemian, Kobra Salimian Rizi, Hassan Rajabi Vardanjani, Farshad Nojoomi
Background & Objective: The spread of carbapenem-resistant Pseudomonas aeruginosa is a global concern. Metallo-beta-lactamase (MBL) enzymes cause extensive drug resistance among Gram-negative bacteria. The current study aimed at determining the prevalence of MBL-producing P. aeruginosa in Iran. Data extraction: A total of 43 studies were found out of which 36 were adopted. Data were collected from Google, Google Scholar, Science Direct, PubMed, Scopus, Embase, and Sciverse...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29760758/upper-normal-limit-of-thyroid-stimulating-hormone-and-metabolic-syndrome-in-iranian-patients-with-obesity
#17
Zohreh Nozarian, Alireza Abdollahi, Vahid Mehrtash, Hirbod Nasiri Bonaki
Background: The current study aimed at evaluating the association between thyroid-stimulating hormone (TSH) level in upper normal limits with metabolic syndrome, modifiable risk factor for cardiovascular disease, and its components according to Adult Treatment Panel III of National Cholesterol Education Program. Methods: The current cross sectional study recruited 82 patients with euthyroid overweight or obesity. They all had body mass index (BMI) higher than 25 kg/m2 ...
2017: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29760757/inhibitory-activities-of-platelet-rich-and-platelet-poor-plasma-on-the-growth-of-pathogenic-bacteria
#18
Omid Maghsoudi, Reza Ranjbar, Seyyed Hesamoddin Mirjalili, Mahdi Fasihi-Ramandi
Background: The utility and efficacy of novel materials in tissue regeneration and antimicrobial therapy are contingent upon the employment of either blood derivatives rich in platelets or platelet-poor-plasma (PPP). This effect is largely mediated by the increased or decreased concentration of platelets in the plasma. The current study aimed to analyze and evaluate the impact of platelet-rich (PRP) or PPP on inhibiting the growth of human pathogenic bacteria and compare their effects with those of chloramphenicol and penicillin...
2017: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29760756/alpha-synuclein-expression-in-acute-erythroleukaemia-acute-megakaryoblastic-leukemia-and-normal-counterparts-in-bone-marrow
#19
Farid Kosari, Sanam Akbarzadeh Hosseini, Hiva Saffar
Background: Alpha-synuclein is a member of synuclein family of proteins with unidentified function localized in the cytoplasm, mitochondria of neurons, and presynaptic nerve endings. Although it is found in the Lewy bodies in synucleinopathies and in Alzheimer's disease, the protein could also be considered as a novel marker in diagnosis of diseases related to the hematopoietic system. Methods: The current study evaluated alpha-synuclein expression in bone marrow sections obtained from 9 patients with acute myeloblastic leukemia (AML)-M6, 2 patients with AML-M7, and 56 patients with other forms of AML by immunohistochemical (IHC) analysis...
2017: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29760755/fluorescent-in-situ-hybridization-and-real-time-quantitative-polymerase-chain-reaction-to-evaluate-her-2-neu-status-in-breast-cancer
#20
Fatemeh Homaei Shandiz, Azar Fani, Sepideh Shakeri, Maryam Sheikhi, Abouzar Ramezani Farkhani, Arezoo Shajiei, Hossein Ayatollahi
Background: Breast cancer remains the most common and second lethal cancer in females. HER-2/neu is one of the most important amplified oncogene in breast cancer. The amplification of HER-2 is correlated with decreased survival, metastasis, and early recurrence. The amplification of HER-2/neu gene and synthesis of the protein are reported in 10%-34% of breast cancer cases associated with tumor size, advanced tumor stage, high-grade tumor, young age at diagnosis, absence of steroid hormone receptor, and lymph node involvement...
2017: Iranian Journal of Pathology
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