Xiaoyu Zhao, Tianyi Qiu, Xiner Huang, Qiyu Mao, Yajie Wang, Rui Qiao, Jiayan Li, Tiantian Mao, Yuan Wang, Yewei Cun, Caicui Wang, Cuiting Luo, Chaemin Yoon, Xun Wang, Chen Li, Yuchen Cui, Chaoyue Zhao, Minghui Li, Yanjia Chen, Guonan Cai, Wenye Geng, Zixin Hu, Jinglei Cao, Wenhong Zhang, Zhiwei Cao, Hin Chu, Lei Sun, Pengfei Wang
The current SARS-CoV-2 variants strikingly evade all authorized monoclonal antibodies and threaten the efficacy of serum-neutralizing activity elicited by vaccination or prior infection, urging the need to develop antivirals against SARS-CoV-2 and related sarbecoviruses. Here, we identified both potent and broadly neutralizing antibodies from a five-dose vaccinated donor who exhibited cross-reactive serum-neutralizing activity against diverse coronaviruses. Through single B-cell sorting and sequencing followed by a tailor-made computational pipeline, we successfully selected 86 antibodies with potential cross-neutralizing ability from 684 antibody sequences...
February 6, 2024: Cell Discovery