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Drugs—Real World Outcomes

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https://www.readbyqxmd.com/read/27888478/examining-the-quality-of-medicines-at-kenyan-healthcare-facilities-a-validation-of-an-alternative-post-market-surveillance-model-that-uses-standardized-patients
#1
Francis Wafula, Amy Dolinger, Benjamin Daniels, Njeri Mwaura, Guadalupe Bedoya, Khama Rogo, Ana Goicoechea, Jishnu Das, Bernard Olayo
BACKGROUND: Promoting access to medicines requires concurrent efforts to strengthen quality assurance for sustained impact. Although problems of substandard and falsified medicines have been documented in low- and middle-income countries, reliable information on quality is rarely available. OBJECTIVE: The aim of this study was to validate an alternative post-market surveillance model to complement existing models. METHODS: The study used standardized patients or mystery clients (people recruited from the local community and trained to pose as real patients) to collect medicine samples after presenting a pre-specified condition...
November 25, 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27888477/impact-of-pediatric-acute-otitis-media-on-child-and-parental-quality-of-life-and-associated-productivity-loss-in-malaysia-a-prospective-observational-study
#2
Bruce Crawford, Siti Sabzah Mohd Hashim, Narayanan Prepageran, Goh Bee See, Genevieve Meier, Keiko Wada, Cheryl Coon, Emmanuelle Delgleize, Michael DeRosa
BACKGROUND: Acute otitis media (AOM) affects both child and parental quality of life (QoL). Data on QoL associated with AOM in Malaysia is sparse, and the burden of indirect costs have not been previously reported. OBJECTIVE: To determine the effect of pediatric AOM on child and parental QoL in Malaysia and its economic impact (indirect costs). METHODS: We utilized a set of QoL questionnaires (PAR-AOM-QOL, OM-6, and EQ-5D) combined with questions addressing work/productivity loss and financial costs associated with caring for a child during his or her illness in an observational, multicenter, prospective study...
November 25, 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27864792/readmission-risk-in-chronic-obstructive-pulmonary-disease-patients-comparative-study-of-nebulized-%C3%AE-2-agonists
#3
Vamsi Bollu, Annie Guérin, Geneviève Gauthier, Robert Hiscock, Eric Q Wu
BACKGROUND: Bronchodilators are used for managing the symptoms of chronic obstructive pulmonary disease (COPD) and minimizing the risk of hospitalization and readmission. Hospital readmission is predictive of morbidity and mortality. OBJECTIVE: The study objective was to compare all-cause readmission risk in COPD patients receiving nebulized long-acting β2-agonists (neb-LABAs) versus nebulized short-acting β2-agonists (neb-SABA) following COPD-related hospitalization discharge...
November 18, 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27873285/prescription-drug-use-and-polypharmacy-among-medicaid-enrolled-adults-with-autism-a-retrospective-cross-sectional-analysis
#4
Rini Vohra, Suresh Madhavan, Usha Sambamoorthi, Claire StPeter, Susannah Poe, Nilanjana Dwibedi, Mayank Ajmera
BACKGROUND: A lack of gold standard treatment for autism spectrum disorders (ASD), no clear ASD management guidelines, and lack of evidence-based pharmacological interventions other than aripiprazole and risperidone elevate the risk of off-label prescribing and adverse effects among individuals with ASD, more so among adults. OBJECTIVE: The aim of this study was to identify and compare the types of prescription drug use, rates of polypharmacy, and characteristics associated with polypharmacy among adults with and without ASD in a retrospective cross-sectional analysis of a three-state Medicaid Analytic eXtract database (2000-2008)...
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27796967/acknowledgement-to-referees
#5
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27787771/patterns-of-drug-use-and-serum-sodium-concentrations-in-older-hospitalized-patients-a-latent-class-analysis-approach
#6
Richard J Woodman, Karen M Wood, Aline Kunnel, Maneesha Dedigama, Matthew A Pegoli, Roy L Soiza, Arduino A Mangoni
BACKGROUND: Several drugs may lower serum sodium concentrations (NaC) in older patients. However, distinguishing their individual effects is particularly difficult in this population because of the high prevalence of polypharmacy and disease states that are per se associated with hyponatremia. OBJECTIVES: Our objective was to identify specific patterns of medication use in older hospitalized patients and determine whether these patterns were associated with serum NaC...
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27757919/comparing-biologic-cost-per-treated-patient-across-indications-among-adult-us-managed-care-patients-a-retrospective-cohort-study
#7
Tao Gu, Neel Shah, Gaurav Deshpande, Derek H Tang, Debra F Eisenberg
BACKGROUND: The relative cost of biologics in the treatment of autoimmune disorders, including rheumatoid arthritis, psoriatic arthritis, psoriasis, and ankylosing spondylitis, is a key consideration for managed care payers. OBJECTIVES: Our objective was to estimate biologic costs and treatment patterns in US managed care patients with rheumatoid arthritis, psoriatic arthritis, psoriasis, and/or ankylosing spondylitis. METHODS: This retrospective study used administrative claims data from the HealthCore Integrated Research Database (HIRD(SM)) for adults with rheumatoid arthritis, psoriatic arthritis, psoriasis, and/or ankylosing spondylitis who received abatacept, adalimumab, certolizumab, etanercept, golimumab, infliximab, rituximab, tocilizumab, or ustekinumab between 1 July 2009 and 31 January 2013...
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747602/documentation-of-functional-medication-management-in-older-adults-a-retrospective-chart-review-in-acute-care-hospitalization
#8
Monika Bolina, C Allyson Jones, Sheri Koshman, Erin Heintz, Cheryl A Sadowski
BACKGROUND: Functional skills can affect the ability of older adults to appropriately manage their medication regimens. Research evaluating a patient's functional ability or the assessment of medication management is limited. OBJECTIVES: Our objective was to describe the documented components of functional medication management (FMM) in adults aged ≥65 years during an acute hospital stay. The secondary objective was to describe the characteristics of the healthcare providers (HCP) who document FMM...
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747601/idiosyncratic-drug-induced-severe-neutropenia-and-agranulocytosis-in-elderly-patients-%C3%A2-75%C3%A2-years-a-monocentric-cohort-study-of-61-cases
#9
Rachel Mourot-Cottet, Frédéric Maloisel, François Séverac, Olivier Keller, Thomas Vogel, Martine Tebacher, Jean-Christophe Weber, Georges Kaltenbach, Jacques-Eric Gottenberg, Bernard Goichot, Jean Sibilia, Anne-Sophie Korganow, Raoul Herbrecht, Emmanuel Andrès
BACKGROUND: Little data is currently available in the literature on neutropenia and agranulocytosis in the elderly, and, to our knowledge, idiosyncratic drug-induced agranulocytosis is particularly poorly covered, or not at all. OBJECTIVE: We herein describe the clinical picture and outcome of patients aged ≥75 years with established idiosyncratic drug-induced agranulocytosis. PATIENTS AND METHODS: Data from 61 patients over 75 years old with idiosyncratic drug-induced agranulocytosis were retrospectively reviewed...
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747837/first-line-treatment-with-bevacizumab-and-platinum-doublet-combination-in-non-squamous-non-small-cell-lung-cancer-a-retrospective-cohort-study-in-us-oncology-community-practices
#10
Orsolya E Lunacsek, Arliene Ravelo, Anna D Coutinho, Sebastien J Hazard, Mark R Green, Joanne Willey, Michael Eaddy, Hans-Peter Goertz
BACKGROUND: Real-world evidence is lacking on the impact of bevacizumab added to carboplatin/paclitaxel (Bev + CP) therapy versus CP alone for patients with non-squamous non-small cell lung cancer (NS-NSCLC), particularly in those excluded from clinical trials. METHODS: This is a retrospective electronic medical record analysis of patients who received first-line therapy with Bev + CP or CP between 1 October 2006 and 30 June 2013. We identified four subsets: elderly patients (≥65 years), patients with brain/central nervous system (CNS) metastases, patients with Eastern Cooperative Oncology Group performance status (ECOG PS) ≥2, and patients receiving anticoagulation...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747836/claims-data-analysis-of-tumor-necrosis-factor-inhibitor-treatment-dosing-among-patients-with-rheumatoid-arthritis-a-systematic-review-of-methods
#11
Gundula Krack, Henning Zeidler, Jan Zeidler
BACKGROUND: With tumor necrosis factor inhibitors, changes of dosing, switching between drugs, insufficient adherence, and persistence are frequent in rheumatoid arthritis. Because this is often associated with decreased efficiency and increased costs, dosage analyses based on claims data are of increasing interest for healthcare providers and payers. Nevertheless, no standardized methods exist to ensure high-quality research. OBJECTIVE: In this review, we compare and discuss applied methods in claims data-based dosage analyses of tumor necrosis factor inhibitor prescriptions in patients with rheumatoid arthritis...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747835/mortality-rates-in-users-of-typical-and-atypical-antipsychotics-a-database-study-in-poland
#12
Pawel Zagozdzon, Bartosz Goyke, Magdalena Wrotkowska
BACKGROUND: The role of antipsychotics in influencing mortality of patients with mental disorders is still unexplained. OBJECTIVE: The aim of this study was to determine mortality rates of patients treated with atypical and typical antipsychotics and to compare these data with the mortality rates for the general population. METHODS: The study was based on the 2008-2012 prescription drug reimbursement data from the Polish National Health Fund in Gdansk and mortality data from the death registry...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747834/real-life-effectiveness-and-safety-of-amlodipine-valsartan-single-pill-combination-in-patients-with-hypertension-in-egypt-results-from-the-excite-study
#13
Samir H Assaad-Khalil, Nashwa Nashaat
BACKGROUND: EXCITE (clinical experience of amlodipine and valsartan in hypertension) evaluated the real-world effectiveness and safety of single-pill combinations (SPCs) of amlodipine/valsartan (Aml/Val) and amlodipine/valsartan/hydrochlorothiazide (Aml/Val/HCTZ) in patients with hypertension from the Middle East and Asia. OBJECTIVE: The objective of this study was to report the results of EXCITE study from Egypt, where all patients were prescribed Aml/Val. METHODS: This was a 26-week, observational, multicenter, prospective, non-interventional, open-label study...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747833/potentially-inappropriate-medications-in-elderly-haemodialysis-patients-using-the-stopp-criteria
#14
Krystina Parker, Willy Aasebø, Knut Stavem
BACKGROUND: Polypharmacy is commonly applied to elderly haemodialysis patients for treating terminal renal failure and multiple co-morbidities. Potentially inappropriate medications (PIMs) in multidrug regimens in geriatric populations can be identified using specially designed screening tools. OBJECTIVE: The aims of this study were to estimate the prevalence of PIMs by applying the Screening Tool of Older Persons' Prescriptions (STOPP) criteria and the Beers criteria to elderly haemodialysis patients and to assess the association of some risk factors with the presence of PIMs...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747832/general-practitioners-prescribing-patterns-at-primary-healthcare-centers-in-national-health-insurance-gezira-sudan
#15
Bashir Mohamed Elmahi Yousif, Siripen Supakankunti
BACKGROUND: The appropriate use of medicines is essential for the provision of quality health services, patient safety, and the rational use of health resources. In Sudan, general practitioners (GPs) provide 80 % of insured patients' health services. Pharmaceutical service costs have been increasing since 2010. OBJECTIVES: We aimed to use the World Health Organization (WHO) and International Network for the Rational Use of Drugs prescribing indicators to assess prescription quality among GPs in different types of primary healthcare centers (PHCCs) within the National Health Insurance Fund (NHIF) in Gezira State, Sudan...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747831/improving-the-identification-of-out-of-hospital-sudden-cardiac-deaths-in-a-general-practice-research-database
#16
Cristina Varas-Lorenzo, Alejandro Arana, Catherine B Johannes, Lisa J McQuay, Kenneth J Rothman, Daniel Fife
BACKGROUND: The ascertainment of sudden cardiac death (SCD) in electronic health databases is challenging. OBJECTIVES: Our objective was to evaluate the applicability of the validated computer definition of SCD developed by Chung et al. in a retrospective study of SCD and domperidone exposure in the Clinical Practice Research Datalink (CPRD). METHODS: We assessed out-of-hospital SCD by applying the validated computer definition and linking data with Hospital Episode Statistics and death certificates...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747830/potentially-inappropriate-medication-use-in-multimorbid-elderly-inpatients-differences-between-the-forta-priscus-and-stopp-ratings
#17
Beate Wickop, Steffen Härterich, Christian Sommer, Anne Daubmann, Michael Baehr, Claudia Langebrake
BACKGROUND: Several classifications to identify and avoid use of potentially inappropriate medications (PIMs) in the elderly have been published. To what extent these classifications match each other and whether there are differences in the prevalence of PIM use at admission, during the inpatient stay and at discharge are largely unreported. OBJECTIVES: To determine the PIM prevalence in elderly patients at a university hospital, with a special focus on different classification systems and the chronological sequence, and to examine a possible association between PIM use and the reason for admission, as well as severe side effects and consequences of PIM use during hospitalization...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747829/risk-factors-associated-with-the-requirement-for-pharmaceutical-intervention-in-the-hospital-setting-a-systematic-review-of-the-literature
#18
Emma Suggett, John Marriott
BACKGROUND: A number of methods exist for the risk assessment of hospital inpatients to determine the likelihood of patients experiencing drug-related problems (DRPs), including manual review of a patient's medication (medication reviews) and more complex electronic assessment using decision support alerts in electronic prescribing systems. A systematic review was conducted to determine the evidence base for potential risks associated with adult hospital inpatients that could not only lead to medication-related issues but might also be directly associated with pharmacist intervention...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747828/differences-in-benzodiazepine-receptor-agonist-use-in-rural-and-urban-older-adults
#19
Meghan K Mattos, Susan M Sereika, Jennifer G Naples, Steven M Albert
BACKGROUND: Older adults are especially susceptible to adverse consequences of potentially inappropriate medications (PIMs), such as benzodiazepine receptor agonists (BZDRAs), due to age-related pharmacokinetic and pharmacodynamic changes. Although some risk factors for BZDRA use in older adults have been identified, the role of rural versus urban residence is less clear. OBJECTIVE: To describe BZDRA use in rural versus urban older adults using pharmaceutical claims from Pennsylvania's Pharmaceutical Assistance Contract for the Elderly (PACE) program...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747827/beta-blocker-therapy-early-after-myocardial-infarction-a-comparison-between-medication-at-hospital-discharge-and-subsequent-pharmacy-dispensed-medication
#20
Susanne Bendesgaard Pedersen, Jens Cosedis Nielsen, Hans Erik Bøtker, Jeffrey J Goldberger
BACKGROUND: Beta-blocker (BB) therapy after myocardial infarction (MI) reduces all-cause mortality. OBJECTIVE: The aim of this study was to investigate BB dosing patterns and compliance following MI. METHODS: Using medical patient files and nationwide databases, we identified 100 patients who were discharged following MI in 2012 from Aarhus University Hospital, Denmark, and subsequently redeemed one or more BB prescriptions within 6 months...
September 2016: Drugs—Real World Outcomes
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