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Drugs—Real World Outcomes

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https://www.readbyqxmd.com/read/30460662/impact-of-age-comorbidity-and-figo-stage-on-treatment-choice-and-mortality-in-older-danish-patients-with-gynecological-cancer-a-retrospective-register-based-cohort-study
#1
Sambavy Nadaraja, Trine Lembrecht Jørgensen, Lars-Erik Matzen, Jørn Herrstedt
BACKGROUND: The number of older patients with cancer is increasing in general, and ovarian and endometrial cancer are to a large extent cancers of the elderly. Older patients with cancer have a high prevalence of comorbidity. Comorbidity and age may be predictive of treatment choice and mortality in older patients with cancer along with stage and performance status. OBJECTIVES: The aim of this study was to describe comorbidity in a population of older Danish patients with gynecological cancer, and to evaluate the predictive value of comorbidity and age on treatment choice and cancer-specific and all-cause mortality...
December 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/30298445/impact-of-definitive-drug-drug-interaction-testing-on-medication-management-and-patient-care
#2
Renée J G Arnold, Jun Tang, Joshua Schrecker, Cheryl Hild
BACKGROUND AND OBJECTIVE: Aegis Sciences Corporation developed a test (InterACT Rx™ ) that objectively and definitively identifies substances known to interact with drug-drug interaction-prone medications commonly prescribed in the treatment of chronic pain and behavioral health disorders. The objective of this study was to assess the severity of identified drug-drug interactions, the reduction in the frequency and severity of identified drug-drug interactions, and the impact of the test on healthcare utilization...
December 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/30194620/inappropriate-prescribing-in-elderly-inpatients-at-a-university-hospital-in-saudi-arabia
#3
Nisreen Abdulrahman Jastaniah, Ahmed Saeed Almaqati, Anas Khaleel Alsuraihi, Sultan Adnan Abughanim, Mohammed Aseeri
BACKGROUND AND OBJECTIVES: Elderly populations usually use more medications than any other age group and are therefore more susceptible to potentially inappropriate prescribing (PIP), drug-drug interactions, and the related health consequences. In this study, we aimed to determine PIP prevalence and explore the most common potentially inappropriate medications (PIMs) prescribed. METHODS: This was a retrospective study involving elderly patients admitted at King Abdulaziz Medical City-Jeddah (KAMC-JD), between November 2014 and January 2015...
December 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/30155832/safety-profile-of-drug-use-during-pregnancy-at-peripheral-health-centres-in-burkina-faso-a-prospective-observational-cohort-study
#4
Toussaint Rouamba, Innocent Valea, Joel D Bognini, Herve Kpoda, Petra F Mens, Melba F Gomes, Halidou Tinto, Fati Kirakoya-Samadoulougou
PURPOSE: Safety data of many drugs used during pregnancy remain scarce. This is especially true in developing countries characterised by the absence of a robust pharmacovigilance system, high prevalence of different tropical diseases affecting patients and potential for drug-drug interactions. This study aimed to assess the safety profile of drugs used in women at high risk of malaria during pregnancy and delivery in Burkina Faso's health facilities. It also aimed to assess factors associated with the use of potentially risky drugs over the entire course of pregnancy...
September 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/30105744/patient-understanding-of-the-neuropsychiatric-risks-associated-with-branded-bupropion-hydrochloride-products-used-for-smoking-cessation
#5
John Ascher, Annette Stemhagen, Monika Stender, Beta Win, Christina Winter
BACKGROUND: Bupropion hydrochloride (Zyban) is an effective aid to smoking cessation; however, its use has previously been associated with neuropsychiatric adverse events. Here we report results of the patient Knowledge, Attitudes, and Behavior survey that forms part of the Year 7 Risk Evaluation and Mitigation Strategy (REMS) assessment for Zyban. OBJECTIVE: Assess participants' understanding of the neuropsychiatric risks associated with branded bupropion hydrochloride products that are used for smoking cessation, as described in the Medication Guides...
September 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/30073580/persistence-with-biological-disease-modifying-antirheumatic-drugs-and-its-associated-resource-utilization-and-costs
#6
Rosarin Sruamsiri, Hideto Kameda, Jörg Mahlich
OBJECTIVE: The study assessed persistence rates of biological disease-modifying antirheumatic drugs (bDMARDs) for the treatment of rheumatoid arthritis in Japan and compared resource utilization and treatment costs between persistence and non-persistence groups. METHODS: Data were extracted from a Japanese claims database between 2009 and 2015. bDMARD-naïve patients were identified and included in the final analysis. Survival analysis was used to estimate 1-year persistence rates for current bDMARDs...
September 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29946913/clinical-outcomes-with-first-line-chemotherapy-in-a-large-retrospective-study-of-patients-with-metastatic-pancreatic-cancer-treated-in-a-us-community-oncology-setting
#7
Thomas H Cartwright, Monika Parisi, Janet L Espirito, Thomas W Wilson, Corey Pelletier, Manish Patel, Hani M Babiker
BACKGROUND: The combination chemotherapy regimens of nab-paclitaxel plus gemcitabine (nab-p + G) and FOLFIRINOX (FFX) have each demonstrated improved survival compared with gemcitabine monotherapy in clinical trials for metastatic pancreatic cancer; however, limited comparative data exist. OBJECTIVE: The objective of this study was to compare patient characteristics and clinical outcomes including time to treatment failure and overall survival in patients with metastatic pancreatic cancer receiving first-line chemotherapy in the community...
September 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29934933/real-world-adverse-effects-of-capecitabine-toxicity-in-an-elderly-population
#8
Michiel W H van Beek, Monique Roukens, Wilco C H Jacobs, Johanna N H Timmer-Bonte, Cees Kramers
BACKGROUND: Few studies have assessed the safety and effectiveness of the numerous available chemotherapeutic therapies for geriatric oncology patients. Most safety studies are conducted in large trials, and there is some uncertainty surrounding whether the results would be the same in typical daily use. OBJECTIVE: This retrospective study aims to assess the adverse effects of real-world capecitabine use in elderly patients. METHODS: We reviewed the records of patients treated with capecitabine in an oncology department of a University Clinic in Nijmegen, The Netherlands...
June 22, 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29916196/recent-trends-in-the-practice-of-procedural-sedation-under-local-anesthesia-for-catheter-ablation-gastrointestinal-endoscopy-and-endoscopic-surgery-in-japan-a-retrospective-database-study-in-clinical-practice-from-2012-to-2015
#9
Akiko Matsui, Michihiro Morimoto, Hiroshi Suzuki, Thomas Laurent, Yoko Fujimoto, Yoshimi Inagaki
OBJECTIVES: To investigate changes in sedation practice during 2012-2015, using a large health claims database, for catheter ablation (CA), gastrointestinal endoscopic examination (EE), and surgery (ES) after dexmedetomidine (DEX) was approved for procedural sedation in 2013. We assessed the trends of sedative utilization, sedative-analgesic combinations, and, additionally, incidence of complications from 2012 to 2015. METHODS: Using the database provided by Medical Data Vision Co...
June 18, 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29790022/compliance-with-pregnancy-prevention-recommendations-for-isotretinoin-in-estonia-in-2012-2016
#10
Anneli Uusküla, Heti Pisarev, Katrin Kurvits, Ott Laius, Made Laanpere, Maia Uusküla
BACKGROUND: Isotretinoin is an effective treatment for severe acne; no alternative treatment has an equal therapeutic effect. The teratogenic effects of isotretinoin can be avoided, and numerous recommendations and regulations are in force to minimize the risk of pregnancy during treatment. OBJECTIVES: To describe isotretinoin prescription patterns for women aged 15-45 years, assess the concomitancy of isotretinoin and contraceptive use, and determine the rate of potential isotretinoin-exposed pregnancies in Estonia...
June 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29725886/spontaneous-reporting-on-adverse-events-by-consumers-in-the-united-states-an-analysis-of-the-food-and-drug-administration-adverse-event-reporting-system-database
#11
Tadashi Toki, Shunsuke Ono
BACKGROUND: Voluntary reports on adverse events (AEs) submitted by consumers have been facilitated through the MedWatch program in the United States (US), but few studies have described the characteristics of voluntary reports. OBJECTIVE: The aim of this study was to reveal the characteristics of current voluntary reports on AEs reported by consumers and healthcare professionals. METHODS: We performed analysis on voluntary reports of AEs in the US Food and Drug Administration AE Reporting System (FAERS) database submitted in 2016...
June 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29651691/pattern-of-antimicrobial-resistance-among-bacterial-isolates-from-urogenital-clinical-specimens-a-descriptive-study-from-the-buea-health-district-cameroon
#12
Elvis Tajoache Amin, Charles Njumkeng, Belmond T Kika, Akemfua Fualefac, Patrick Njukeng
INTRODUCTION: Antimicrobial resistance has become a global concern and is particularly affecting developing countries where infectious diseases and poverty are endemic. The effectiveness of currently available antimicrobials is decreasing as a result of increasing resistant strains among clinical isolates. OBJECTIVES: The aim of this study was to determine the resistance pattern of bacterial isolates from different clinical urogenital specimens at different hospitals in the Buea Health District, Cameroon...
June 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29476420/an-evaluation-of-drug-ineffective-postmarketing-reports-in-drug-safety-surveillance
#13
Takashi Misu, Cindy M Kortepeter, Monica A Muñoz, Eileen Wu, Gerald J Dal Pan
INTRODUCTION: The most commonly reported adverse event, based on frequency of Medical Dictionary for Regulatory Activities (MedDRA) preferred terms (PTs), in the US FDA Adverse Event Reporting System (FAERS) database is "drug ineffective" (DI). This study aimed to describe the DI reports and provide data to support recommendations on how to best evaluate these reports. METHODS: We characterized all FAERS reports coded with the MedDRA PT "drug ineffective" received between 1 September 2012 and 31 August 2016 using all other FAERS reports as a comparator...
June 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29736842/use-of-topical-tacrolimus-and-topical-pimecrolimus-in-four-european-countries-a-multicentre-database-cohort-study
#14
Josephina G Kuiper, Myrthe P P van Herk-Sukel, Jordi Castellsague, Anton Pottegård, Ingegärd Anveden Berglind, Daniel Dedman, Lia Gutierrez, Brian Calingaert, Jesper Hallas, Anders Sundström, Arlene M Gallagher, James A Kaye, Carolina Pardo, Kenneth J Rothman, Susana Perez-Gutthann
BACKGROUND: Despite the concerns about a potential increased risk of skin cancer and lymphoma with the use of topical tacrolimus and pimecrolimus, no population-based studies have given an overview of the use of these drugs in Europe. OBJECTIVE: To assess the use of topical tacrolimus and pimecrolimus in children and adults in Europe. METHODS: Multicentre database cohort study comprising data from the Netherlands, Denmark, Sweden and the UK...
May 7, 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29363022/economic-impact-in-medicaid-beneficiaries-with-schizophrenia-and-cardiometabolic-comorbidities-treated-with-once-monthly-paliperidone-palmitate-vs-oral-atypical-antipsychotics
#15
Marie-Hélène Lafeuille, Neeta Tandon, Sean Tiggelaar, Rhiannon Kamstra, Patrick Lefebvre, Edward Kim, Yong Yue, Kruti Joshi
OBJECTIVE: The objective of this study was to compare persistence, costs, and healthcare resource utilization in patients with schizophrenia and cardiometabolic comorbidities treated with once-monthly paliperidone palmitate or an oral atypical antipsychotic. METHODS: Medicaid data from six states (07/2009-03/2015) were used to identify adults with schizophrenia and cardiometabolic comorbidities initiated on once-monthly paliperidone palmitate or an oral atypical antipsychotic (index date) on 01/2010 or after...
March 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29305714/diagnoses-of-cardiovascular-disease-or-substance-addiction-abuse-in-us-adults-treated-for-adhd-with-stimulants-or-atomoxetine-is-use-consistent-with-product-labeling
#16
Kathleen A Fairman, Lindsay E Davis, Alyssa M Peckham, David A Sclar
BACKGROUND: Among US adults, utilization of pharmacotherapy for attention-deficit hyperactivity disorder (ADHD) has increased more than ninefold since 1995-1996. Potential contraindications to ADHD pharmacotherapy include serious cardiovascular disease (CVD) and, for stimulants, addictions and bipolar disorder (BPD). OBJECTIVE: To assess the prevalence of potential contraindications among adults treated with ADHD pharmacotherapy. METHODS: A retrospective cohort analysis was performed using the Truven Health MarketScan® database...
March 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29218595/quantitative-testing-of-prescriber-knowledge-regarding-the-risks-and-safe-use-of-albiglutide
#17
Carol Koro, Janet Pientka, Veronica Bainbridge, Natalie O'Donnell, Monika Stender, Annette Stemhagen
BACKGROUND: The risk of pancreatitis and potential risk of medullary thyroid carcinoma associated with glucagon-like peptide-1 receptor agonists prompted the US Food and Drug Administration to require a Risk Evaluation and Mitigation Strategy for albiglutide, including education for prescribers and subsequent assessment of their knowledge of the risks and safe use of albiglutide via a quantitative survey. OBJECTIVE: The objective of this study was to assess prescribers' knowledge of the risks related to medullary thyroid carcinoma, pancreatitis, and the appropriate patient population for albiglutide...
March 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29188591/contact-dermatitis-after-prescription-of-an-ophthalmic-ointment-containing-fradiomycin-sulfate-a-retrospective-database-study-using-japanese-health-insurance-claims-data
#18
Naomi Sugimoto, Kazuhiko Kuribayashi, Yuji Yamamoto, Satoshi Nagayasu, Osamu Suga, Yoko Fujimoto
BACKGROUND: Topical ointments containing fradiomycin sulfate, such as fradiomycin sulfate/methylprednisolone (F/M) and fradiomycin sulfate/betamethasone sodium phosphate (F/B), are known to cause allergic contact dermatitis (CD) in some patients, especially when used for the periocular region. F/M is commonly prescribed to patients for various conditions; however, there are no reports with respect to the incidence of CD caused by F/M in actual practice. OBJECTIVE: The aim was to investigate the incidence of CD using a data-based retrospective cohort study...
March 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29185233/estimating-prevalence-and-healthcare-utilization-for-treatment-resistant-depression-in-japan-a-retrospective-claims-database-study
#19
Jörg Mahlich, Sunny Tsukazawa, Frank Wiegand
BACKGROUND: Major depressive disorders (MDDs) including treatment-resistant depression (TRD) are common disabling conditions, but data on their epidemiology in Japan are limited. This study investigated the incidence, epidemiology, and direct medical costs of TRD and pharmaceutically-treated depression (PTD) in Japan to increase our health economic understanding of this phenotype of MDD. METHODS: A retrospective cohort study from a private health insurance claims database estimated the 1-year incidence of PTD and TRD and described the health services used and direct medical costs associated with these conditions...
March 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29138993/adverse-drug-events-and-medication-errors-in-african-hospitals-a-systematic-review
#20
REVIEW
Alemayehu B Mekonnen, Tariq M Alhawassi, Andrew J McLachlan, Jo-Anne E Brien
BACKGROUND: Medication errors and adverse drug events are universal problems contributing to patient harm but the magnitude of these problems in Africa remains unclear. OBJECTIVE: The objective of this study was to systematically investigate the literature on the extent of medication errors and adverse drug events, and the factors contributing to medication errors in African hospitals. METHODS: We searched PubMed, MEDLINE, EMBASE, Web of Science and Global Health databases from inception to 31 August, 2017 and hand searched the reference lists of included studies...
March 2018: Drugs—Real World Outcomes
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