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Journals Journal of Clinical and Transl...

Journal of Clinical and Translational Hepatology

https://read.qxmd.com/read/38343606/comprehensive-bile-acid-profiling-of-abcb4-mutated-patients-and-the-prognostic-role-of-taurine-conjugated-3%C3%AE-6%C3%AE-7%C3%AE-12%C3%AE-tetrahydroxylated-bile-acid-in-cholestasis
#21
JOURNAL ARTICLE
Teng Liu, Ren-Xue Wang, Jun Han, Zhong-Die Li, Jonathan A Sheps, Li-Juan Zheng, Xiao-Xiao Xu, Victor Ling, Jian-She Wang
BACKGROUND AND AIMS: We asked if comprehensive bile acid profiling could provide insights into the physiopathology of ABCB4 -mutated patients and evaluated the prognostic value of taurine-conjugated tetrahydroxylated bile acid (tauro-THBA) in cholestasis. METHODS: Serum bile acid profiles were evaluated in 13 ABCB4 -mutated patients with 65 healthy controls by ultra-high-performance liquid chromatography/multiple-reaction monitoring-mass spectrometry (UPLC/MRM-MS)...
February 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38343605/update-on-the-diagnosis-and-treatment-of-combined-hepatocellular-cholangiocarcinoma
#22
REVIEW
Kai-Jian Chu, Yoshikuni Kawaguchi, Han Wang, Xiao-Qing Jiang, Kiyoshi Hasegawa
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a unique type of liver tumor that contains both hepatocellular carcinoma and cholangiocarcinoma components within a single tumor. The fifth edition of the World Health Organization classification provides a definition and diagnostic criteria for cHCC-CCA. However, the heterogeneous histomorphology and presentation resulting from variation of the proportion of each component poses challenges for clinical diagnosis and treatment. A diagnosis of cHCC-CCA may be suggested by the synchronous elevation of serum tumor markers for hepatocellular carcinoma and cholangiocarcinoma, a mixed enhancement pattern on imaging, and a discrepancy between the elevation of tumor marker and the imaging enhancement pattern...
February 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38250470/establishment-and-validation-of-a-four-stress-granule-related-gene-signature-in-hepatocellular-carcinoma
#23
JOURNAL ARTICLE
Mengzhu Li, Xiude Fan, Jiajun Zhao, Dawei Wang
BACKGROUND AND AIMS: Stress granules (SGs) as membrane-less cytoplasmic foci formed in response to unfavorable external stimuli could promote cancer cells to adapt to hostile environments. Hepatocellular carcinoma (HCC) is prone to be highly aggressive once diagnosed, which markedly reduces patient survival time. Therefore, it is crucial to develop valid diagnostic markers to prognosticate HCC patient prognosis, which promotes individualized precision therapeutics in HCC. Considering the pro-tumorigenic activity of SGs, it is of great potential value to construct a prognostic tool for HCC based on the expression profiles of SG-related genes (SGGs)...
January 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38250469/update-on-the-sting-signaling-pathway-in-developing-nonalcoholic-fatty-liver-disease
#24
REVIEW
Wei Liu, Zhili Zhang Chen, Chenhui Yang, Yaofu Fan, Liang Qiao, Shaofeng Xie, Lin Cao
Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition with limited treatment options. Inflammation caused by metabolic disturbances plays a significant role in NAFLD development. Stimulator of interferon gene (STING), a critical regulator of innate immunity, induces the production of interferons and other pro-inflammatory factors by recognizing cytoplasmic DNA to defend against pathogen infection. The STING-mediated signaling pathway appears to play a vital role in hepatic inflammation, metabolic disorders, and even carcinogenesis...
January 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38250468/corrigendum-osteopontin-promotes-macrophage-m1-polarization-by-activation-of-the-jak1-stat1-hmgb1-signaling-pathway-in-nonalcoholic-fatty-liver-disease
#25
(no author information available yet)
[This corrects the article DOI: 10.14218/JCTH.2021.00474.].
January 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38250467/artesunate-induces-ferroptosis-in-hepatic-stellate-cells-and-alleviates-liver-fibrosis-via-the-rock1-atf3-axis
#26
JOURNAL ARTICLE
Yingqian Wang, Yujia Li, Yangling Qiu, Min Shen, Ling Wang, Jiangjuan Shao, Feng Zhang, Xuefen Xu, Zili Zhang, Mei Guo, Shizhong Zheng
BACKGROUND AND AIMS: Development of fibrosis in chronic liver disease requires activation of hepatic stellate cells (HSCs) and leads to a poor outcome. Artesunate (Art) is an ester derivative of artemisinin that can induce ferroptosis in HSCs, and activated transcriptional factor 3 (ATF3) is an ATF/CREB transcription factor that is induced in response to stress. In this study, we examined the role of the Rho-associated protein kinase 1 (ROCK1)/ATF3 axis in Art-induced ferroptosis in HSCs...
January 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38250466/new-first-line-immunotherapy-based-therapies-for-unresectable-hepatocellular-carcinoma-a-living-network-meta-analysis
#27
JOURNAL ARTICLE
Jian-Jian Chen, Zhi-Cheng Jin, Biao Luo, Yu-Qing Wang, Rui Li, Hai-Dong Zhu, Gao-Jun Teng
BACKGROUND AND AIMS: Several first-line immune checkpoint inhibitor (ICI)-based combination therapies have been identified for unresectable hepatocellular carcinoma (uHCC). This network meta-analysis (NMA) aimed to provide the most updated evidence about the preferred first-line ICI-based regimens for uHCC. METHODS: A comprehensive literature search was performed in various databases from database inception to May 2022. The phase 3 trials evaluating first-line single-agent ICIs, molecular-target agents (MTAs), or their combinations in uHCC were included...
January 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38250465/l-graft-7-has-high-accuracy-in-predicting-early-allograft-failure-after-liver-transplantation-a-multicenter-cohort-study-in-china
#28
JOURNAL ARTICLE
Songming Li, Qijie Luo, Shirui Chen, Zehua Jia, Tielong Wang, Xinyu Yu, Wenjing Wang, YuyiZhang, Jiaxing Zhu, Feiwen Deng, Qiang Sun, Zhiyong Guo, Xiaoshun He
BACKGROUND AND AIMS: Increasing utilization of extended criteria donor leads to an increasing rate of early allograft failure after liver transplantation. However, consensus of definition of early allograft failure is lacking. METHODS: A retrospective, multicenter study was performed to validate the Liver Graft Assessment Following Transplantation (L-GrAFT) risk model in a Chinese cohort of 942 adult patients undergoing primary liver transplantation at three Chinese centers...
January 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38250464/associations-between-active-passive-smoking-and-the-risk-of-nonalcoholic-fatty-liver-disease
#29
JOURNAL ARTICLE
Xinyuan Ge, Jing Lu, Chengxiao Yu, Wen Guo, Ting Tian, Xin Xu, Yuqing Ding, Jiaxin Gao, Wei Zhao, Xiaohua Zhou, Qingqing Diao, Hongxia Ma, Qun Zhang, Ci Song, Hongbing Shen
No abstract text is available yet for this article.
January 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38250463/e2f1-mediated-up-regulation-of-ncapg-promotes-hepatocellular-carcinoma-development-by-inhibiting-pyroptosis
#30
JOURNAL ARTICLE
Cuicui Xiao, Jiao Gong, Yusheng Jie, Weicheng Liang, Yan Tai, Wei Qin, Tongyu Lu, Yutian Chong, Ziqing Hei, Bo Hu, Qi Zhang
BACKGROUND AND AIMS: As a subunit of the condensin complex, NCAPG has an important role in maintaining chromosome condensation, but its biological function and regulatory mechanism in hepatocellular carcinoma (HCC) remains undefined. METHODS: The prognostic ability of NCAPG in HCC patients was examined by univariate and multivariate Cox regression analysis. ROC curves were plotted to compare the predictive ability of NCAPG and AFP. Double luciferase reporter system, and ChIP were used to investigate transcriptional potential of E2F1 to NCAPG...
January 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38250462/single-cell-technologies-provide-novel-insights-into-liver-physiology-and-pathology
#31
REVIEW
Guanzi Chen, Wenli Xu, Zhicong Long, Yutian Chong, Bingliang Lin, Yusheng Jie
The liver is the largest glandular organ in the body and has a unique distribution of cells and biomolecules. However, the treatment outcome of end-stage liver disease is extremely poor. Single-cell sequencing is a new advanced and powerful technique for identifying rare cell populations and biomolecules by analyzing the characteristics of gene expression between individual cells. These cells and biomolecules might be used as potential targets for immunotherapy of liver diseases and contribute to the development of precise individualized treatment...
January 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38250461/hepatocellular-ballooning-is-due-to-highly-pronounced-glycogenosis-potentially-associated-with-steatosis-and-metabolic-reprogramming
#32
JOURNAL ARTICLE
Silvia Ribback, Kristin Peters, Mohd Yasser, Jessica Prey, Paula Wilhelmi, Qin Su, Frank Dombrowski, Peter Bannasch
BACKGROUND AND AIMS: Hepatocellular ballooning is a common finding in chronic liver disease, mainly characterized by rarefied cytoplasm that often contains Mallory-Denk bodies (MDB). Ballooning has mostly been attributed to degeneration but its striking resemblance to glycogenotic/steatotic changes characterizing preneoplastic hepatocellular lesions in animal models and chronic human liver diseases prompts the question whether ballooned hepatocytes (BH) are damaged cells on the path to death or rather viable cells, possibly involved in neoplastic development...
January 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38250460/liver-lesions-at-risk-of-transformation-into-hepatocellular-carcinoma-in-cirrhotic-patients-hepatobiliary-phase-hypointense-nodules-without-arterial-phase-hyperenhancement
#33
REVIEW
Nicolò Brandi, Matteo Renzulli
Recent technical advances in liver imaging and surveillance for patients at high risk for developing hepatocellular carcinoma (HCC) have led to an increase in the detection of borderline hepatic nodules in the gray area of multistep carcinogenesis, particularly in those that are hypointense at the hepatobiliary phase (HBP) and do not show arterial phase hyperenhancement. Given their potential to transform and advance into hypervascular HCC, these nodules have progressively attracted the interest of the scientific community...
January 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38250459/unique-genetic-features-of-lean-nafld-a-review-of-mechanisms-and-clinical-implications
#34
REVIEW
Jasmine Tidwell, George Y Wu
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the global population. About 20% have a normal body mass index (BMI) and a variant known as lean NAFLD. Unlike typical NAFLD cases associated with obesity and diabetes, lean NAFLD causes liver disease by mechanisms not related to excess weight or insulin resistance. Genetic disorders are among the major factors in developing lean NAFLD, and genome-wide association studies have identified several genes associated with the condition. This review aims to increase awareness by describing the genetic markers linked to NAFLD and the defects involved in developing lean NAFLD...
January 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38161505/antiviral-therapy-favors-a-lower-risk-of-liver-cirrhosis-in-hbeag-negative-chronic-hepatitis-b-with-normal-alanine-transaminase-and-hbv-dna-positivity
#35
JOURNAL ARTICLE
Jing Zhou, Fa-Da Wang, Lan-Qing Li, Yu-Jin Li, Shi-Yan Wang, En-Qiang Chen
BACKGROUND AND AIMS: Direct evidence on the outcomes of hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients with normal alanine transaminase after long-term antiviral treatment is lacking. METHODS: HBeAg-negative patients with normal ALT and positive HBV DNA (≥20 IU/mL) were retrospectively enrolled. The endpoints included virological response (HBV DNA<100 IU/mL), changes in aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 index (FIB-4), and the incidence of liver nodules, cirrhosis, and hepatocellular carcinoma (HCC)...
December 28, 2023: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38161504/2023-reviewer-acknowledgement
#36
JOURNAL ARTICLE
Editorial Office Of Journal Of Clinical And Translational Hepatology
No abstract text is available yet for this article.
December 28, 2023: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38161503/nonalcoholic-fatty-liver-disease-and-the-intestinal-microbiome-an-inseparable-link
#37
REVIEW
Maria Effenberger, Christoph Grander, Felix Grabherr, Herbert Tilg
Nonalcoholic fatty liver disease (NAFLD) particularly affects patients with type 2 diabetes and obesity. The incidence of NAFLD has increased significantly over the last decades and is now pandemically across the globe. It is a complex systemic disease comprising hepatic lipid accumulation, inflammation, lipotoxicity, gut dysbiosis, and insulin resistance as main features and with the potential to progress to cirrhosis and hepatocellular carcinoma (HCC). In numerous animal and human studies the gut microbiota plays a key role in the pathogenesis of NAFLD, NAFLD-cirrhosis and NAFLD-associated HCC...
December 28, 2023: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38161502/novel-approaches-to-inhibition-of-hbsag-expression-from-cccdna-and-chromosomal-integrants-a-review
#38
REVIEW
Ahmed H Abdelwahed, Brent D Heineman, George Y Wu
Hepatitis B virus (HBV) is a widely prevalent liver infection that can cause acute or chronic hepatitis. Although current treatment modalities are highly effective in the suppression of viral levels, they cannot eliminate the virus or achieve definitive cure. This is a consequence of the complex nature of HBV-host interactions. Major challenges to achieving sustained viral suppression include the presence of a high viral burden from the HBV DNA and hepatitis B surface antigen (HBsAg), the presence of reservoirs for HBV replication and antigen production, and the HBV-impaired innate and adaptive immune response of the host...
December 28, 2023: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38161501/hepatocellular-carcinoma-risk-scores-from-modeling-to-real-clinical-practice-in-areas-highly-endemic-for-hepatitis-b-infection
#39
REVIEW
Xin Hao, Rong Fan, Hong-Mei Zeng, Jin-Lin Hou
Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and represents a global health challenge. Liver cancer ranks third in cancer-related mortality with 830,000 deaths and sixth in incidence with 906,000 new cases annually worldwide. HCC most commonly occurs in patients with underlying liver disease, especially chronic hepatitis B virus (HBV) infection in highly endemic areas. Predicting HCC risk based on scoring models for patients with chronic liver disease is a simple, effective strategy for identifying and stratifying patients to improve the early diagnosis rate and prognosis of HCC...
December 28, 2023: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38161500/liquid-liver-biopsy-for-disease-diagnosis-and-prognosis
#40
REVIEW
Desislava K Tsoneva, Martin N Ivanov, Manlio Vinciguerra
Liver diseases are a major burden worldwide, the scope of which is expected to further grow in the upcoming years. Clinically relevant liver dysfunction-related blood markers such as alanine aminotransferase and aspartate aminotransferase have limited accuracy. Nowadays, liver biopsy remains the gold standard for several liver-related pathologies, posing a risk of complication due to its invasive nature. Liquid biopsy is a minimally invasive approach, which has shown substantial potential in the diagnosis, prognosis, and monitoring of liver diseases by detecting disease-associated particles such as proteins and RNA molecules in biological fluids...
December 28, 2023: Journal of Clinical and Translational Hepatology
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