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Advances in Medical Mycology (Iran)

H Mirhendi, Y Nishiyama, A Rezaei-Matehkolaei, K Satoh, K Makimura
[This corrects the article DOI: 10.18869/acadpub.cmm.2.2.2.].
March 2018: Advances in Medical Mycology (Iran)
Simhadri Vsdna Nagesh, Muthuchamy Muniappan, Iyanar Kannan, Subramanyam Viswanathan
[This corrects the article DOI: 10.29252/cmm.3.4.6.].
March 2018: Advances in Medical Mycology (Iran)
Ali Ghajari, Ensieh Lotfali, Maryam Norouzi, Zahra Arab-Mazar
Background and Purpose: Cryptococcus. magnus is a non- Cryptococcus neoformans species isolated from certain plants, soil, air, and arctic glaciers. Case report: This report describes a case of a 23-year-old Iranian female with pruritus and vaginal irritation. Conventional tests and molecular analysis of the samples of vaginal discharge were performed. The mentioned analyses revealed Cryptococcus magnus as the causative agent of vaginal infection. The minimum inhibitory concentration analysis revealed that this species is susceptible to itraconazole, fluconazole, ketoconazole, and amphotericin B...
March 2018: Advances in Medical Mycology (Iran)
Mahboobeh Kharazi, Bahram Ahmadi, Koichi Makimura, Armin Farhang, Sahar Kianipour, Marjan Motamedi, Hossein Mirhendi
Background and Purpose: Candida parapsilosis is a common cause of candidemia in children and patients with onco-hematological diseases, septic arthritis, peritonitis, vaginitis, and nail and skin infections. Regarding this, the present study was condcuted to evaluate intra- and inter-species variation within beta-tubulin DNA sequence of C. parapsilosis complex in order to establish the utilization of this gene in the identification and phylogenetic analysis of the species. Materials and Methods: A total of 23 isolates representing three different species of C...
March 2018: Advances in Medical Mycology (Iran)
Saeid Mahdavi Omran, Zahra Yousefzade, Soraya Khafri, Mojtaba Taghizadeh-Armaki, Keyvan Kiakojuri
Background and Purpose: There are controversial findings regarding the efficacy of antifungal drugs in the treatment of a ruptured eardrum following fungal infections. Regarding this, the aim of the present study was to evaluate the therapeutic effect of the co-administration of antifungal and antibacterial agents in the treatment of otomycosis with tympanic membrane perforation. Materials and Methods: This analytical, clinical trial was conducted on 87 patients with otomycosis showing no bacterial elements in the direct observation and culture...
March 2018: Advances in Medical Mycology (Iran)
Parastoo Hassani Abharian, Parvin Dehghan, Peyman Hassani Abharian, Sepideh Tolouei
Background and Purpose: Candida dubliniensis is closely related to the most pathogenic and prevalent yeast, namely C. albicans. Candida species can opportunistically overgrow in vulnerable individuals and cause a variety of diseases. The current study aimed to identify and isolate C. dubliniensis species present in the Candida albicans species complex identified in the oral cavity of drug abusers. Materials and Methods: This study was conducted on 53 strains of C...
March 2018: Advances in Medical Mycology (Iran)
Louis Jacob, Mara John, Matthias Kalder, Karel Kostev
Background and Purpose: To the best of our knowledge, no information is available regarding the treatment of vulvovaginal candidiasis in gynecological practices. The goal of this study was to analyze the prevalence of vulvovaginal candidiasis (VVC) and the drugs prescribed for the treatment of this condition in women followed in gynecological practices in Germany. Materials and Methods: All the women followed in 262 gynecological practices between November 2014 and October 2016 were included in this study...
March 2018: Advances in Medical Mycology (Iran)
Nasser Keikha, Mahdieh Shafaghat, Seyed Mohamad Mousavia, Mahdiyeh Moudi, Farshid Keshavarzi
Background and Purpose: Vulvovaginal candidiasis is one of the most common infections in female genital organs, which is caused by Candida species. Candida albicans is the causative agent of more than 80% of infections, and the role of non- Candida strains in the disease etiology is less prominent. The expansion of Azoles resistance among C. albicans strains is considered an important medical problem. According to previous studies, Vitex agnus-castus (vitex) has some antimicrobial effects...
March 2018: Advances in Medical Mycology (Iran)
Ali Poostforoushfard, Ahmad R Pishgar, Enayat Berizi, Hasti Nouraei, Zahra Sobhani, Rohallah Mirzaie, Kamiar Zomorodian
Background and Purpose: Patulin is one of the important mycotoxins, produced by a wide range of molds, including Penicillium , Aspergillus, and Bysochlamys. Patulin is mainly found in the rotten parts of fruits and vegetables, such as apples, pears, peach, apricots, and grapes. Currently, the Codex Alimentarius and Food and Drug Administration have recommended a maximum level of 50 µg/L patulin for apple products. The purpose of this study was to investigate patulin contamination of apple juice and cans in 75 samples collected from 15 manufacturers in Shiraz, southern Iran...
December 2017: Advances in Medical Mycology (Iran)
Mahnaz Fatahinia, Sima Jafarpour, Abdollah Rafiei, Simin Taghipour, Koichi Makimura, Ali Rezaei-Matehkolaei
Background and Purpose: Onychomycosis is fungal infection of the nails with an overall increasing incidence, worldwide. The epidemiological aspects of onychomycosis in Khuzestan, Iran, have not been established. In this study, we aimed to evaluate the clinical and mycological status of fungal nail infection in Khuzestan Province, Iran. Materials and Methods: The study population included 433 patients (143 males vs. 290 females). Nail samples underwent primary direct microscopy and culture...
December 2017: Advances in Medical Mycology (Iran)
Majid Alizadeh, Anna Kolecka, Teun Boekhout, Hossein Zarrinfar, Mohamad A Ghanbari Nahzag, Parisa Badiee, Ali Rezaei-Matehkolaei, Abdolmajid Fata, Somayeh Dolatabadi, Mohammad J Najafzadeh
Background and Purpose: Vulvovaginal candidiasis (VVC) is a common problem in women. The purpose of this study was to identify Candida isolates by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) from women with vulvovaginitis that were referred to Ghaem Hospital, Mashhad, Iran. Materials and Methods: This study was conducted on 65 clinical samples isolated from women that were referred to Ghaem Hospital. All specimens were identified using phenotyping techniques, such as microscopy and culture on Sabouraud dextrose agar and corn meal agar...
December 2017: Advances in Medical Mycology (Iran)
Hamid Badali, Sassan Rezaie, Jacques F Meis, Setareh Agha Kuchak Afshari, Mona Modiri, Ferry Hagen, Maryam Moazeni, Rasoul Mohammadi, Sadegh Khodavaisy
Background and Purpose: Candida parapsilosis is a predominant species found in nosocomial infection, particularly in hospitalized patients. The molecular epidemiology of the clinical strains of this species has not been well studied. The present study was performed with the aim of investigating the microsatellite genotyping of Candida parapsilosis among the Iranian clinical isolates. Materials and Methods: This study was conducted on 81 independent clinical C. parapsilosis isolates that were genotyped by using a panel of six microsatellite markers...
December 2017: Advances in Medical Mycology (Iran)
Nagesh Simhadri Vsdna, Muthuchamy Muniappan, Iyanar Kannan, Subramanyam Viswanathan
Background and Purpose: Soleshine is a polyherbal preparation established in the market for the treatment of cracks and tinea pedis, which is applied externally. This preparation is composed of the extracts of indigenous plants, namely Azadirachta indica, Lawsonia alba, and Shorea robusta , mixed with castor oil and sesame oil. In the present study, an attempt was made to identify the constituents of soleshine and identify some potential drug-like molecules that can inhibit important drug targets of the dermatophytes using molecular docking method...
December 2017: Advances in Medical Mycology (Iran)
Maryam Noori, Mohammad Dakhili, Asghar Sepahvand, Nader Davari
Background and Purpose: Annually affecting millions of women, vulvovaginal candidiasis (VVC) is commonly described by signs and symptoms of vulvovaginal inflammation in the presence of  Candida  species. Today, the detection of the virulence factors plays a major role in the understanding of pathogenesis of candidiasis and helps produce new anticandidial drugs to improve its treatment efficiency. Herein, we aimed to evaluate the esterase and hemolysin activities of the vaginal isolates of Candida and their relationship with the presence of VVC...
December 2017: Advances in Medical Mycology (Iran)
Mohammad T Ismail, Abeer Al-Kafri, Mazen Ismail
Background and Purpose: Otomycosis is a fungal infection that frequently involves the external auditory canal. The epidemiologic data on the etiologic agents of otomycosis in Syria are very limited. In this study, we aimed to determine the fungal agents, gender distribution, and clinical presentation of otomycosis. Materials and Methods: Two hundred and ninety nine patients (153 [51.17%] male and 146 [48.83%] female) clinically prediagnosed as otomycosis were studied at Al-mouassat University Hospital and ENT Crescent Syrian Clinic...
September 2017: Advances in Medical Mycology (Iran)
Sima Darabian, Sayed Jamal Hashemi, Sadegh Khodavaisy, Somayeh Sharifynia, Mohammad Kord, Maryam Akbari Dana, Farzad Aala, Sassan Rezaie
Background and Purpose: Aspergillosis is one of the most common opportunistic fungal infections in immunocompromised and neutropenic patients. Aspergillus fumigatus ( A. fumigatus ) is the most common causative agent of this infection. Due to variable CO2 concentrations that pathogens are exposed to during the infection process and to understand the role of CO2 , we examined the effects of various CO2 concentrations as one of the environmental factors on morphological changes and induction of antifungal resistance in A...
September 2017: Advances in Medical Mycology (Iran)
Nasrin Parsameher, Sassan Rezaei, Sadegh Khodavasiy, Samira Salari, Sanaz Hadizade, Mohammad Kord, Seyed Amin Ayatollahi Mousavi
Background and Purpose: Candida albicans is the most common Candida species (sp.) isolated from fungal infections. Azole resistance in Candida species has been considerably increased in the last decades. Given the toxicity of the antimicrobial drugs, resistance to antifungal agents, and drug interactions, the identification of new antifungal agents seems essential. In this study, we assessed the antifungal effects of biogenic selenium nanoparticles on C. albicans and determined the expression of ERG11 and CDR1 genes...
September 2017: Advances in Medical Mycology (Iran)
Zahra Jafari, Marjan Motamedi, Nilufar Jalalizand, Gholam R Shokoohi, Arezu Charsizadeh, Hossein Mirhendi
Background and Purpose: The epidemiological alteration in the distribution of Candida species, as well as the significantly increasing trend of either intrinsic or acquired resistance of some of these fungi highlights the need for a reliable method for the identification of the species. Polymerase chain reaction (PCR) is one of the methods facilitating the quick and precise identification of Candida species. The aim of this study was to compare the efficiency of CHROMagar, PCR-restriction fragment length polymorphism (PCR-RFLP), and PCR-fragment size polymorphism (PCR-FSP) assays in the identification of Candida species to determine the benefits and limitations of these methods...
September 2017: Advances in Medical Mycology (Iran)
Mohammad J Najafzadeh, Karim Jalaeian Samani, Jos Houbraken, Majid Alizadeh, Abdolmajid Fata, Ali Naseri, Hossein Zarrinfar, Mehdi Bakhshaee
Background and Purpose: Rhinosinusitis is a common disorder, influencing approximately 20% of the population at some time of their lives. It was recognized and reported with expanding recurrence over the past two decades worldwide. Undoubtedly, correct diagnosis of fungi in patients with fungal rhinosinusitis affects the treatment planning and prognosis of the patients. Identification of the causative agents using the standard mycological procedures remains difficult and time-consuming...
September 2017: Advances in Medical Mycology (Iran)
Ali Kamali, Sareh Mehni, Mohadeseh Kamali, Mehdi Taheri Sarvtin
Background and Purpose: Breastfeeding plays an important role in the growth and development of infants. However, breast milk may be contaminated with various mycotoxins. Ochratoxin A is one of the most important mycotoxins with nephrotoxic, carcinogenic, teratogenic, genotoxic, and immunotoxic properties. Thus, we carried out this study to determine the concentration of ochratoxin A in human breast milk in Jiroft, Kerman Province, south of Iran. Materials and Methods: Eighty-four human breast milk samples were collected from mothers visiting the number one clinic in Jiroft city...
September 2017: Advances in Medical Mycology (Iran)
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