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Kidney Research and Clinical Practice

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https://www.readbyqxmd.com/read/27957424/bullous-skin-lesions-in-a-patient-with-end-stage-renal-disease-combined-with-myeloma-and-primary-amyloidosis
#1
Jong Hwan Jung
No abstract text is available yet for this article.
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27957423/crystalline-podocytopathy-and-tubulopathy-without-overt-glomerular-proteinuria-in-a-patient-with-multiple-myeloma
#2
Eun Jeong Lee, Su Yeon Lee, So Young Park, Yonjin Kim, Jae Shin Choi, Mi Jeoung Kim, Ji Hyeon Park, Jung Eun Lee, Ghee Young Kwon, Yoon-Goo Kim
Crystalline nephropathy is a rare yet well-known condition associated with multiple myeloma and other light chain-secreting disorders. Paraproteins that are resistant to proteolysis crystallize within proximal tubular cells and cause light-chain proximal tubulopathy, which presents clinically as Fanconi syndrome. Podocytes are rarely affected, and the crystalline inclusions within podocytes are typically precipitated, yielding significant glomerular proteinuria. Here we report a case of extensive crystalline inclusions primarily within podocytes and proximal tubules that presented only with Fanconi syndrome and renal insufficiency...
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27957422/unmasked-chronic-renal-function-deterioration-after-unilateral-adrenalectomy-in-patients-with-primary-aldosteronism
#3
Su Min Park, Woo Jin Jung, Jong Man Park, Harin Rhee, Il Young Kim, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Nari Shin, Sang Heon Song
We report 2 cases of chronic estimated glomerular filtration rate (eGFR) decline after unilateral adrenalectomy due to primary aldosteronism. The patients were diagnosed with unilateral adrenal cortical adenoma releasing aldosterone. Two patients were examined for hypertension and hypokalemia. Unilateral laparoscopic adrenalectomy was performed in both cases, and pathology confirmed adrenal cortical adenoma. After adrenalectomy, hypertension and hypokalemia improved to within normal range. However, the eGFR decreased postoperatively, and abdominal computed tomography scan showed decreased kidney size compared to previous images...
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27957421/acute-interstitial-nephritis-induced-by-solanum-nigrum
#4
Sung Sik Oh, Myung Woo Choi, Mi Rim Choi, Jong Hwa Lee, Hyun Ju Yang, Yeong Jin Choi, A Young Cho, Kwang Young Lee, In O Sun
Acute interstitial nephritis (AIN) is an important cause of reversible acute kidney injury and pathologically characterized by inflammatory infiltrate in the renal interstitium. Solanum nigrum (S. nigrum) is a medicinal plant member of the Solanaceae family. Although S. nigrum has been traditionally used to treat various ailments such as pain, inflammation, and fever, it has also been reported to have a toxic effect, resulting in anticholinergic symptoms. However, there have been no reports of AIN caused by S...
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27957420/technique-failure-in-korean-incident-peritoneal-dialysis-patients-a-national-population-based-study
#5
Shina Lee, Hyunwook Kim, Kyoung Hoon Kim, Hoo Jae Hann, Hyeong Sik Ahn, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Dong-Ryeol Ryu
BACKGROUND: Technique failure is an important issue for peritoneal dialysis (PD) patients. In this study, we aimed to analyze technique failure rate in detail and to determine the predictors for technique failure in Korea. METHODS: We identified all patients who had started dialysis between January 1, 2005, and December 31, 2008, in Korea, using the Korean Health Insurance Review and Assessment Service database. A total of 7,614 PD patients were included, and the median follow-up was 24...
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27957419/pulmonary-vein-isolation-alone-and-combined-with-renal-sympathetic-denervation-in-chronic-kidney-disease-patients-with-refractory-atrial-fibrillation
#6
Márcio G Kiuchi, Shaojie Chen, Gustavo R E Silva, Luis M R Paz, Tetsuaki Kiuchi, Ary G de Paula Filho, Gladyston L L Souto
BACKGROUND: Atrial fibrillation (AF) commonly occurs in association with chronic kidney disease (CKD), resulting in adverse outcomes. Combining pulmonary vein isolation (PVI) and renal sympathetic denervation (RSD) may reduce the recurrence of AF in patients with CKD and hypertension. We considered that RSD could reduce the recurrence of AF in patients with CKD by modulating sympathetic hyperactivity. Our goal was to compare the impact of PVI + RSD with that of PVI alone in patients with concurrent AF and CKD...
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27957418/beneficial-effects-of-tonsillectomy-plus-steroid-pulse-therapy-on-inflammatory-and-tubular-markers-in-patients-with-iga-nephropathy
#7
Shuntaro Maruyama, Tomohito Gohda, Yusuke Suzuki, Hitoshi Suzuki, Yuji Sonoda, Saki Ichikawa, Zi Li, Maki Murakoshi, Satoshi Horikoshi, Yasuhiko Tomino
BACKGROUND: IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide. Tonsillectomy plus steroid pulse therapy has been able to induce clinical remission in early-stage IgAN. However, its possible effect on systemic and local cytokines and tubular markers has not been fully investigated. METHODS: We obtained serum and urine samples from 38 patients just before renal biopsy and third steroid pulse therapy. Markers of tubular damage such as N-acetyl-β-d-glucosaminidase, and kidney injury molecule-1 and inflammation such as interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 were measured by immunoassay...
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27957417/comparison-of-clinical-characteristics-of-patients-with-acute-kidney-injury-after-intravenous-versus-inhaled-colistin-therapy
#8
A Young Cho, Hyun Ju Yoon, Jung Cheol Lee, Jin Young Kwak, Kwang Young Lee, In O Sun
BACKGROUND: The aim of this study was to investigate the incidence and clinical characteristics of intravenous (IV) or inhaled (IH) colistin-associated acute kidney injury (AKI) using the Risk, Injury, Failure, Loss, End-stage Renal Disease criteria. METHODS: From 2010 to 2014, 160 patients were treated with IV or IH colistin. Of these, we included 126 patients who received colistin for > 72 hours for the treatment of pneumonia and compared the incidence and clinical characteristics of patients in the IV (n = 107) and IH (n = 19) groups...
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27957416/plasma-renin-activity-and-risk-of-cardiovascular-and-mortality-outcomes-among-individuals-with-elevated-and-nonelevated-blood-pressure
#9
Simran K Bhandari, Michael Batech, Jiaxiao Shi, Steven J Jacobsen, John J Sim
BACKGROUND: We sought to evaluate plasma renin activity (PRA) levels and risk of mortality and cardiovascular events among individuals with elevated blood pressure [systolic blood pressure (SBP) ≥ 140 mmHg] and those with controlled blood pressure (SBP < 140 mmHg) in a large diverse population. METHODS: A retrospective cohort study between January 1, 2007, and December 31, 2013, among adults (≥ 18 years) within an integrated health system was conducted...
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27957415/the-role-of-local-il6-jak2-stat3-signaling-in-high-glucose-induced-podocyte-hypertrophy
#10
Hyung Ah Jo, Joo-Young Kim, Seung Hee Yang, Seung Seok Han, Kwon Wook Joo, Yon Su Kim, Dong Ki Kim
BACKGROUND: Interleukin-6 (IL6) is an important regulator of cellular hypertrophy through the gp130/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway. We tested the hypothesis that IL6 and its downstream gp130/JAK2/STAT3 pathway participated in high glucose (HG)-induced podocyte hypertrophy. METHODS: IL6 levels in the media and lysates of podocytes were measured by enzyme-linked immunosorbent assay. Western blots were performed to determine the protein expression levels of gp130/JAK2/STAT3 among podocytes cultured with normal glucose (NG), NG + mannitol, NG + recombinant IL6, HG, and HG + IL6-neutralizing antibodies (IL6NAb)...
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27957414/current-characteristics-of-dialysis-therapy-in-korea-2015-registry-data-focusing-on-elderly-patients
#11
REVIEW
Dong-Chan Jin, Sung-Ro Yun, Seoung Woo Lee, Sang-Woong Han, Won Kim, Jongha Park
Because of increases in the elderly population and diabetic patients, the proportion of elderly among dialysis patients has rapidly increased during the last decades. The mortality and morbidity of these elderly dialysis patients are obviously much higher than those of young patients, but large analytic studies about elderly dialysis patients' characteristics have rarely been published. The registry committee of the Korean Society of Nephrology has collected data about dialysis therapy in Korea through an Internet online registry program and analyzed the characteristics...
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27957413/diagnosis-and-treatment-of-patients-with-iga-nephropathy-in-japan
#12
REVIEW
Yasuhiko Tomino
Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. Although CKD is not one specific disease, it is a comprehensive syndrome that includes IgA nephropathy. As reported by the Japanese Society of Nephrology, 13.0 million people have CKD. In Japan, major causes of end-stage kidney disease are type 2 diabetic nephropathy, chronic glomerulonephritis, especially IgA nephropathy, hypertensive nephrosclerosis, and polycystic kidney disease...
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27957412/interleukin-6-signaling-in-podocyte-hypertrophy
#13
EDITORIAL
Dae Ryong Cha
No abstract text is available yet for this article.
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27668167/the-authors-reply
#14
Jihyun Yang, Wonyong Cho
No abstract text is available yet for this article.
September 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27668166/the-association-between-acute-kidney-injury-in-renal-infarction-and-progression-to-chronic-kidney-disease
#15
Yun Kyu Oh
No abstract text is available yet for this article.
September 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27668165/henoch-sch%C3%A3-nlein-purpura-nephritis-and-colitis-in-an-adult-patient-with-alcoholic-liver-cirrhosis
#16
Jong Hwan Jung
No abstract text is available yet for this article.
September 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27668164/cardiac-arrest-caused-by-nafamostat-mesilate
#17
Hyo Shik Kim, Kyung Eun Lee, Ji Hyun Oh, Chan Sung Jung, Dughyun Choi, Yunsuek Kim, Jin Seok Jeon, Dong Cheol Han, Hyunjin Noh
A 65-year-old man was transferred from the Department of Vascular Surgery to Nephrology because of cardiac arrest during hemodialysis. He underwent incision and drainage for treatment of a buttock abscess. Nafamostat mesilate was used as an anticoagulant for hemodialysis to address bleeding from the incision and drainage site. Sudden cardiac arrest occurred after 15 minutes of dialysis. The patient was treated in the intensive care unit for 5 days. Continuous veno-venous hemodiafiltration was started without any anticoagulant in the intensive care unit...
September 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27668163/rhabdomyolysis-in-a-patient-taking-nebivolol
#18
Ye Jin Kim, Hae Ri Kim, Hong Jae Jeon, Hyun Jun Ju, Sarah Chung, Dae Eun Choi, Kang Wook Lee, Ki Ryang Na
β Blockers such as propranolol and labetalol are known to induce toxic myopathy because of their partial β2 adrenoceptor agonistic effect. Nebivolol has the highest β1 receptor affinity among β blockers, and it has never been reported to induce rhabdomyolysis until now. We report a patient who developed rhabdomyolysis after changing medication to nebivolol. A 75-year-old woman was admitted to our hospital because of generalized weakness originating 2 weeks before visiting. Approximately 1 month before her admission, her medication was changed from carvedilol 12...
September 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27668162/high-level-viruria-as-a-screening-tool-for-bk-virus-nephropathy-in-renal-transplant-recipients
#19
W James Chon, Nidhi Aggarwal, Masha Kocherginsky, Brenna Kane, Jozefa Sutor, Michelle A Josephson
BACKGROUND: Although early monitoring of BK virus infection in renal transplant patients has led to improved outcomes over the past decade, it remains unclear whether monitoring for viremia is the best screening tool for BK virus nephropathy (BKVN). METHODS: We conducted a retrospective review of the medical records of 368 renal transplant recipients who had a minimum of 18 months of posttransplantation follow-up. The relationship between the presence of BK viruria and a composite end point of BK viremia/BKVN was established, and the predictive value of high-grade BK viruria for development of viremia/BKVN was determined...
September 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27668161/low-prealbumin-levels-are-independently-associated-with-higher-mortality-in-patients-on-peritoneal-dialysis
#20
Kyung Hee Lee, Jang-Hee Cho, Owen Kwon, Sang-Un Kim, Ryang Hi Kim, Young Wook Cho, Hee-Yeon Jung, Ji-Young Choi, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park
BACKGROUND: Prealbumin, a sensitive marker for protein-energy status, is also known as an independent risk factor for mortality in hemodialysis patients. We investigated the impact of prealbumin on survival in incident peritoneal dialysis (PD) patients. METHODS: In total, 136 incident PD patients (mean age, 53.0 ± 15.8 years) between 2002 and 2007 were enrolled in the study. Laboratory data, dialysis adequacy, and nutritional parameters were assessed 3 months after PD initiation...
September 2016: Kidney Research and Clinical Practice
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