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Kidney Research and Clinical Practice

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https://www.readbyqxmd.com/read/30254859/the-authors-reply
#1
Ghada M El-Kannishy
No abstract text is available yet for this article.
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254858/use-of-erythropoiesis-stimulating-agents-in-obese-hemodialysis-patients
#2
COMMENT
Sun-Hee Park
No abstract text is available yet for this article.
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254857/nephroptosis-the-wandering-kidney
#3
Victor Siang Hua Chan, Tina Poy Wing Lam, Wendy Wai Man Lam
No abstract text is available yet for this article.
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254856/calcification-of-the-urinary-bladder-and-ureter-in-schistosomiasis
#4
Hong Joo Lee, Won Sub Sung
No abstract text is available yet for this article.
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254855/membranoproliferative-glomerulonephritis-in-a-patient-with-chronic-brucellosis
#5
Simella Provatopoulou, Marios Papasotiriou, Evangelos Papachristou, Hariklia Gakiopoulou, Markos Marangos, Dimitrios S Goumenos
Brucellosis is the most common zoonotic disease in Greece, with an endemic distribution and can affect any organ. Infiltration of the renal parenchyma causes acute and chronic interstitial nephritis with granulomas, whereas renal glomeruli are rarely affected. The disease has been sporadically reported, and it causes various histopathologic patterns. Herein, we describe the case of a 39-year-old stock breeder with a history of recurrent episodes of bacteremia caused by Brucella melitensis over a period of 3 years...
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254854/use-of-dapagliflozin-in-patients-with-advanced-diabetic-kidney-disease
#6
Hyun Sun Park, Youn Joo Jung, Dong-Young Lee, Kyoung Hyoub Moon, Beom Kim, Hae Won Kim
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are effective for overweight diabetic patients through the induction of glucosuria. However, SGLT2 inhibitors are not recommended for patients with advanced chronic kidney disease (CKD) because they may aggravate renal function and thus become less effective in controlling blood glucose in this patient population. We suggest that adequate hydration would be helpful to prevent the side effects of SGLT2 inhibitors in diabetic patients with advanced CKD. In this study, we review five cases of SGLT2 inhibitor therapy, specifically with dapagliflozin, for the treatment of diabetes mellitus in patients with advanced CKD...
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254853/dihydroxyadenine-crystal-induced-nephropathy-presenting-with-rapidly-progressive-renal-failure
#7
Ritu Verma, Manickam Niraimathi, Pallavi Prasad, Vinita Agrawal
Adenine phosphoribosyltransferase enzyme deficiency is a rare, autosomal recessive disorder. It is a disease limited to the renal system and usually presents with urolithiasis. Herein, we report a young female with dihydroxyadenine (DHA) crystal-induced nephropathy presenting with rapidly progressive renal failure. DHA crystals can be easily diagnosed by their pathognomic color and shape in urine and biopsy specimens. A high index of clinical suspicion helps in the early diagnosis of this potentially treatable renal disease...
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254852/predictive-parameters-of-arteriovenous-fistula-maturation-in-patients-with-end-stage-renal-disease
#8
Muhammad A Siddiqui, Suhel Ashraff, Derek Santos, Robert Rush, Thomas Carline, Zahid Raza
Background: The objevctive of the present study was to explore the potential influence of blood markers and patient factors such as risk factors, kidney function profile, coagulation profile, lipid profile, body mass index, blood pressure, and vein diameter on the maturation of arteriovenous fistula (AVF) in patients with end-stage renal disease. Methods: Retrospective data from 300 patients who had undergone AVF creation at the Royal Infirmary of Edinburgh were examined...
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254851/association-of-serum-mineral-parameters-with-mortality-in-hemodialysis-patients-data-from-the-korean-end-stage-renal-disease-registry
#9
Yunmi Kim, Kyung Don Yoo, Hyo Jin Kim, Junga Koh, Yeonsil Yu, Young Joo Kwon, Gheun-Ho Kim, Tae-Hyun Yoo, Joongyub Lee, Dong-Chan Jin, Bum Soon Choi, Yeong Hoon Kim, Kook-Hwan Oh
Background: We investigated the associations between mineral metabolism parameters and mortality to identify optimal targets in Korean hemodialysis patients. Methods: Among hemodialysis patients registered in the end-stage renal disease registry of the Korean Society of Nephrology between March 2012 and June 2017, those with serum calcium, phosphorus, and intact parathyroid hormone (iPTH) measured at enrollment were included. Association of serum levels of calcium, phosphorus, and iPTH with all-cause mortality was analyzed...
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254850/efficacy-of-low-dose-spironolactone-on-top-of-angiotensin-receptor-blockade-in-patients-with-glomerulonephritis
#10
Byung Chul Yu, Min Sung Lee, Jong Joo Moon, Soo Jeong Choi, Jin Kuk Kim, Seung Duk Hwang, Moo Yong Park
Background: Previous studies have shown that aldosterone antagonists have a proteinuria-lowering effect in patients with proteinuria and progressive proteinuric disease not adequately controlled by the use of angiotensin receptor blockers (ARBs). Aldosterone antagonists, in combination with ARBs, might improve proteinuria in patients with glomerulonephritis (GN). Methods: In the present retrospective study, we evaluated the proteinuria-lowering effect and drug safety of low-dose spironolactone (12...
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254849/anti-phospholipase-a2-receptor-antibody-as-a-prognostic-marker-in-patients-with-primary-membranous-nephropathy
#11
Eun Joo Song, Kye Hwa Jeong, Young Ae Yang, Jeong-Hoon Lim, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park
Background: Phospholipase A2 receptor (PLA2R) has been identified as a major autoantigen in primary membranous nephropathy (MN). We evaluated the association between anti-PLA2R antibodies and clinical outcome in Korean patients with primary MN. Methods: A total of 66 patients with biopsy-proven MN were included. Serum level of anti-PLA2R antibodies was measured by enzyme-linked immunosorbent assay. Biochemical parameters were estimated initially and at follow-up...
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254848/timing-for-initiation-of-sequential-continuous-renal-replacement-therapy-in-patients-on-extracorporeal-membrane-oxygenation
#12
Jin Hyuk Paek, Seohyun Park, Anna Lee, Seokwoo Park, Ho Jun Chin, Ki Young Na, Hajeong Lee, Jung Tak Park, Sejoong Kim
Background: Extracorporeal membrane oxygenation (ECMO) is a lifesaving therapy used in critically ill patients with severe cardiopulmonary dysfunction. Continuous renal replacement therapy (CRRT) is supplemented to treat fluid overload, acute kidney injury, and electrolyte disturbances during ECMO. However, the best time to initiate CRRT is not well-defined. We performed this study to identify the optimal timing of CRRT for ECMO. Methods: We conducted a multicenter retrospective cohort study of 296 patients over 12 years...
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254847/tenofovir-induced-renal-tubular-dysfunction-among-human-immunodeficiency-virus-patients-on-antiretroviral-therapy-in-nigeria-prospects-for-early-detection-of-presymptomatic-nephrotoxicity
#13
Irikefe Paul Obiebi, Ebube Amalachukwu Nwannadi
Background: Tenofovir disoproxil fumarate (TDF) is relatively safe, although renal toxicity has been reported. In Nigeria, there is insufficient data on renal toxicity among patients on TDF. This study assesses TDF-associated tubular dysfunction among human immunodeficiency virus (HIV) patients at a hospital in Nigeria. Methods: In this cohort study, 104 adult HIV patients were recruited with a simple random technique from the outpatient clinic. Biochemical indices of renal function were estimated from serum and urine at the 16th and 24th week after an initial assessment at baseline...
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254846/the-expression-of-two-isoforms-of-matrix-metalloproteinase-2-in-aged-mouse-models-of-diabetes-mellitus-and-chronic-kidney-disease
#14
Harin Rhee, Miyeun Han, Sang Soo Kim, Il Young Kim, Hye Won Lee, Sun Sik Bae, Hong Koo Ha, Eun Soon Jung, Min Young Lee, Eun Young Seong, Dong Won Lee, Soo Bong Lee, David H Lovett, Sang Heon Song
Background: This study was undertaken to explore the effects of aging on the kidneys in mouse models of diabetes and chronic kidney disease (CKD), and to compare the expression of two isoforms of matrix metalloproteinase-2 (MMP-2)-secretory full-length MMP-2 and intracellular N-terminal truncated MMP-2 (NTT-MMP-2)-in these models. Methods: Two experimental ICR mouse models were used: a streptozotocin (STZ)-induced type 1 diabetes mellitus model and a 5/6 nephrectomized (5/6Nx) CKD model...
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254845/puromycin-aminonucleoside-triggers-apoptosis-in-podocytes-by-inducing-endoplasmic-reticulum-stress
#15
Seo-Yoon Min, Dong-Soo Ha, Tae-Sun Ha
Background: Puromycin aminonucleoside (PAN) is a known podocytotoxin. PAN-induced nephrosis is a widely used animal model for studying human idiopathic nephrotic syndrome. Abnormal protein accumulation associated with podocyte-specific endoplasmic reticulum (ER) stress damages cells structurally and functionally, which in turn induces apoptosis and severe proteinuria. In the present study, we investigated the effect of PAN on ER stress and apoptosis in podocytes in vitro . Methods: Mouse podocytes were cultured and treated with various concentrations of PAN...
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254844/noncoding-rnas-as-therapeutic-targets-in-early-stage-diabetic-kidney-disease
#16
REVIEW
Mitsuo Kato
Diabetic kidney disease (DKD) is a major renal complication of diabetes that leads to renal dysfunction and end-stage renal disease (ESRD). Major features of DKD include accumulation of extracellular matrix proteins and glomerular hypertrophy, especially in early stage. Transforming growth factor-β plays key roles in regulation of profibrotic genes and signal transducers such as Akt kinase and MAPK as well as endoplasmic reticulum stress, oxidant stress, and autophagy related to hypertrophy in diabetes. Many drugs targeting the pathogenic signaling in DKD (mostly through protein-coding genes) are under development...
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254843/immune-mechanisms-in-the-different-phases-of-acute-tubular-necrosis
#17
REVIEW
Fedor Kundert, Louise Platen, Takamasa Iwakura, Zhibo Zhao, Julian A Marschner, Hans-Joachim Anders
Acute kidney injury is a clinical syndrome that can be caused by numerous diseases including acute tubular necrosis (ATN). ATN evolves in several phases, all of which are accompanied by different immune mechanisms as an integral component of the disease process. In the early injury phase, regulated necrosis, damage-associated molecular patterns, danger sensing, and neutrophil-driven sterile inflammation enhance each other and contribute to the crescendo of necroinflammation and tissue injury. In the late injury phase, renal dysfunction becomes clinically apparent, and M1 macrophage-driven sterile inflammation contributes to ongoing necroinflammation and renal dysfunction...
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254842/mineralocorticoid-receptor-blockade-for-renoprotection
#18
EDITORIAL
Dae Ryong Cha
No abstract text is available yet for this article.
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/30254841/anti-phospholipase-a2-receptor-antibodies-in-membranous-nephropathy
#19
EDITORIAL
Sangho Lee
No abstract text is available yet for this article.
September 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29971215/erratum-association-of-serum-uric-acid-level-with-coronary-artery-stenosis-severity-in-korean-end-stage-renal-disease-patients-volume-36-issue-3-september-2017-pages-282-289
#20
Hye Yun Jeong, Hye Jeong Cho, Sang Hoon Kim, Jun Chul Kim, Mi Jung Lee, Dong Ho Yang, So-Young Lee
[This corrects the article on p. 282 in vol. 36, PMID: 28904880.].
June 2018: Kidney Research and Clinical Practice
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