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EXCLI Journal

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https://www.readbyqxmd.com/read/28900385/the-impact-of-stress-on-body-function-a-review
#1
REVIEW
Habib Yaribeygi, Yunes Panahi, Hedayat Sahraei, Thomas P Johnston, Amirhossein Sahebkar
Any intrinsic or extrinsic stimulus that evokes a biological response is known as stress. The compensatory responses to these stresses are known as stress responses. Based on the type, timing and severity of the applied stimulus, stress can exert various actions on the body ranging from alterations in homeostasis to life-threatening effects and death. In many cases, the pathophysiological complications of disease arise from stress and the subjects exposed to stress, e.g. those that work or live in stressful environments, have a higher likelihood of many disorders...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28900384/cancer-chemoprevention-by-oleaster-elaeagnus-angustifoli-l-fruit-extract-in-a-model-of-hepatocellular-carcinoma-induced-by-diethylnitrosamine-in-rats
#2
Zahra Amereh, Nasrin Hatami, Farshad H Shirazi, Saman Gholami, Seyed Hojjat Hosseini, Maryam Noubarani, Mohammad Kamalinejad, Sina Andalib, Fariborz Keyhanfar, Mohammad Reza Eskandari
Hepatocellular carcinoma (HCC) is a frequent and fatal human cancer with poor diagnosis that accounts for over half a million deaths each year worldwide. Elaeagnus angustifolia L. known as oleaster has a wide range of pharmacological activities. This study aimed to investigate the chemopreventive effect of aqueous extract of E. angustifolia fruit (AEA) against diethylnitrosamine (DEN)-induced HCC in rats. HCC was induced in rats by a single injection of DEN (200 mg/kg) as an initiator. After two weeks, rats were orally administered 2-acetylaminofluorene or 2-AAF (30 mg/kg) as a promoter for two weeks...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28900383/effects-of-platelet-rich-plasma-and-chondrocyte-co-culture-on-msc-chondrogenesis-hypertrophy-and-pathological-responses
#3
Rouhallah Ramezanifard, Mahboubeh Kabiri, Hana Hanaee Ahvaz
Regarding the inadequate healing capability of cartilage tissue, cell-based therapy is making the future of cartilage repair and regeneration. Mesenchymal stem cells (MSC) have shown great promise in cartilage regeneration. However, a yet-unresolved issue is the emergence of hypertrophic and pathologic markers during in vitro MSC chondrogenesis. Articular chondrocytes (AC) can suppress the undesired hypertrophy when co-cultured with MSC. On the other hand, platelet rich plasma (PRP), is considered potentially effective for cartilage repair and in-vitro chondrogenesis...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28900382/immunization-enhances-the-natural-antibody-repertoire
#4
Dylan Beinart, Daniel Ren, Cinthia Pi, Susan Poulton, Zoie E Holzknecht, Chelsea Swanson, William Parker
The role of immunization in the production of antibodies directed against immunogens is widely appreciated in laboratory animals and in humans. However, the role of immunization in the development of "natural antibodies" has not been investigated. Natural antibodies are those antibodies present without known history of infection or immunization, and react to a wide range of targets, including "cryptic" self-antigens that are exposed upon cell death. In this study, the ability of immunization to elicit the production of natural antibodies in laboratory rats was evaluated...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28900381/the-association-of-vimentin-and-fibronectin-gene-expression-with-epithelial-mesenchymal-transition-and-tumor-malignancy-in-colorectal-carcinoma
#5
Zohreh Niknami, Ali Eslamifar, Amirnader Emamirazavi, Alireza Ebrahimi, Reza Shirkoohi
Colorectal cancer is the most common malignancy of the gastrointestinal tract with very high mortality. One of the most distinguishing features for the establishment of an epithelial-mesenchymal transition phenotype is the alteration of mesenchymal markers expression and structural adhesion proteins. We evaluated the significance of vimentin and fibronectin gene expression in relation to invasion and metastasis in CRC patients. Tissue specimens were collected consecutively from forty-five colorectal carcinoma patients during surgeries...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28900380/meta-analysis-of-neuron-specific-enolase-in-predicting-pediatric-brain-injury-outcomes
#6
Babak Nakhjavan-Shahraki, Mahmoud Yousefifard, Alireza Oraii, Arash Sarveazad, Mostafa Hosseini
A reliable biomarker has not been identified to predict the outcome of traumatic brain injury (TBI) in children. Therefore, the present systematic review and meta-analysis aimed to assess the association between neuron specific enolase (NSE) and traumatic brain injury (TBI) in children. Two independent reviewers searched electronic databases of EMBASE, Cochrane library, Medline and Scopus and then they summarized the results and did a quality control check. At the end, standardized mean difference (SMD) with 95 % confidence interval (CI) and performance of NSE were assessed...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28900379/postmenopausal-hormone-and-the-risk-of-nephrolithiasis-a-meta-analysis
#7
Juan Yu, Binyan Yin
Menopause is reported to be associated with increased urinary calcium excretion, which may enhance the risk for the development of calcium kidney stones. However, it remains controversial about whether high level of postmenopausal hormone (PMH) is a risk factor for formation of nephrolithiasis. Several observational studies have shown that PMH is protective based on 24-hour urinary parameters. Recent clinical trials provided evidence to conclude that estrogen therapy increases the risk of nephrolithiasis in healthy postmenopausal women...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28900378/steroid-resistance-and-concomitant-respiratory-infections-a-challenging-battle-in-pulmonary-clinic
#8
Kamal Dua, Nicole G Hansbro, Philip M Hansbro
No abstract text is available yet for this article.
2017: EXCLI journal
https://www.readbyqxmd.com/read/28900377/serum-soluble-receptor-of-advanced-glycation-end-products-and-risk-of-metabolic-syndrome-in-egyptian-obese-women
#9
Moushira Zaki, Sanaa Kamal, Shams Kholousi, Hala T El-Bassyouni, Walaa Yousef, Hanaa Reyad, Ramy Mohamed, Walaa A Basha
Obesity is one of the diagnostic criteria of metabolic syndrome (MS). It is correlated with insulin resistance (IR) and high vascular risk as well. Advanced glycation end products (AGEs) and their receptor (RAGE) play an important role in abnormal metabolic components in obese women. This study aimed to explore the serum levels of sRAGE in Egyptian obese women and compare with healthy non-obese controls and investigate the relationship between serum sRAGE, metabolic parameters, and obesity complications. The soluble form of receptor for advanced glycation end products (sRAGE), anthropometry, metabolic and biochemical biomarkers were measured in 100 obese women and 100 age-matched healthy control non-obese women...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28900376/physical-activity-and-beta-amyloid-pathology-in-alzheimer-s-disease-a-sound-mind-in-a-sound-body
#10
REVIEW
Khadije Ebrahimi, Alireza Majdi, Behrouz Baghaiee, Seyed Hojjat Hosseini, Saeed Sadigh-Eteghad
Alzheimer's disease (AD) is the most common type of dementia worldwide. Since curative treatment has not been established for AD yet and due to heavy financial and psychological costs of patients' care, special attention has been paid to preventive interventions such as physical activity. Evidence shows that physical activity has protective effects on cognitive function and memory in AD patients. Several pathologic factors are involved in AD-associated cognitive impairment some of which are preventable by physical activity...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28900375/expression-and-purification-of-untagged-glnk-proteins-from-actinobacteria
#11
Edileusa C M Gerhardt, Vivian R Moure, Andrey W Souza, Fabio O Pedrosa, Emanuel M Souza, Lautaro Diacovich, Hugo Gramajo, Luciano F Huergo
The PII protein family constitutes one of the most conserved and well distributed family of signal transduction proteins in nature. These proteins play key roles in nitrogen and carbon metabolism. PII function has been well documented in Gram-negative bacteria. However, there are very few reports describing the in vitro properties and function of PII derived from Gram-positive bacteria. Here we present the heterologous expression and efficient purification protocols for untagged PII from three Actinobacteria of medical and biotechnological interest namely: Mycobacterium tuberculosis, Rhodococcus jostii and Streptomyces coelicolor...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28900374/association-between-polymorphisms-in-the-promoter-region-of-the-apolipoprotein-e-apoe-gene-and-alzheimer-s-disease-a-meta-analysis
#12
Hanyan Xiao, Yifeng Gao, Lei Liu, Yan Li
Several studies have evaluated the role of polymorphisms in the promoter region of APOE gene that encodes apolipoprotein E (APOE) and the susceptibility to Alzheimer's disease (AD). The aim of this literature review and meta-analysis was to investigate the relationship between the APOE promoter region single nucleotide polymorphisms (SNPs) (rs449647, -491A/T; rs769446, -427T/C and rs405509 -219T/G) and the risk of developing AD. Eligible controlled studies published up to November 2016 were retrieved from main online scientific and medical databases...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28900373/mafb-silencing-in-macrophages-does-not-influence-the-initiation-and-growth-of-lung-cancer-induced-by-urethane
#13
Takako Nemoto, Yoko Shibata, Sumito Inoue, Akira Igarashi, Yoshikane Tokairin, Keiko Yamauchi, Tomomi Kimura, Masamichi Sato, Kento Sato, Hiroshi Nakano, Shuichi Abe, Michiko Nishiwaki, Maki Kobayashi, Sujeong Yang, Yukihiro Minegishi, Kodai Furuyama, Hiroyoshi Machida, Isao Kubota
An increased number of tumor-associated macrophages (TAMs) that exhibit the M2 macrophage phenotype is related to poorer prognosis in cancer patients. MafB is a transcription factor regulating the differentiation of macrophages. However, involvement of MafB for the development of TAMs is unknown. This study was designed to investigate the role of MafB in a murine urethane-induced lung cancer model. Urethane was injected intraperitoneally into wild-type and dominant-negative MafB transgenic mice. Twenty-four weeks later, mice were sacrificed and their lungs removed for pathological analysis...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28900372/psychological-stress-has-a-higher-rate-of-developing-addictive-behaviors-compared-to-physical-stress-in-rat-offspring
#14
Masoud Nazeri, Arezoo Ebrahimi, Iraj Aghaei, Samaneh Ghotbi Ravandi, Mohammad Shabani
Prenatal stress could have great influence on development of offspring and might alter cognitive function and other physiological processes of children. The current study was conducted to study the effect of physical or psychological prenatal stress on addictive and anxiety-like behavior of male and female offspring during their adolescence period (postnatal day (PND) 40). Adult female rats were exposed to physical (swimming) or psychological (observing another female rat swimming) stress from day six of gestation for 10 days...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28828001/structure-activity-relationships-and-molecular-docking-studies-of-chromene-and-chromene-based-azo-chromophores-a-novel-series-of-potent-antimicrobial-and-anticancer-agents
#15
Tarek H Afifi, Rawda M Okasha, Hany E A Ahmed, Janez Ilaš, Tarek Saleh, Alaa S Abd-El-Aziz
The design of novel materials with significant biological properties is a main target in drug design research. Chromene compounds represent an interesting medicinal scaffold in drug replacement systems. This report illustrates a successful synthesis and characterization of two novel series of chromene compounds using multi-component reactions. The synthesis of the first example of azo chromophores containing chromene moieties has also been established using the same methodology. The antimicrobial activity of the new molecules has been tested against seven human pathogens including two Gm+ve, two Gm-ve bacteria, and four fungi, and the results of the inhibition zones with minimum inhibitory concentrations were reported as compared to reference drugs...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28828000/microrna-expression-analysis-in-endometriotic-serum-treated-mesenchymal-stem-cells
#16
Mazen Abdel-Rasheed, Ghada Nour Eldeen, Marwa Mahmoud, Mahmoud ElHefnawi, Nourhan Abu-Shahba, Mohamed Reda, Khaled Elsetohy, Michael Nabil, Amr Elnoury, Tamer Taha, Osama Azmy
Endometriosis is defined by presence of endometrial-like-tissue outside the uterus. Recently, ectopic endometriotic lesions have been suggested to originate by abnormal differentiation of endometrial mesenchymal stem cells (eMSCs). MicroRNAs (miRNAs) play an important role in the pathophysiology of endometriosis. Through a PCR array approach, we aimed to assess the differential expression of microRNAs in human eMSC treated in culture with sera derived from women with severe endometriosis. Sera were collected from five patients with severe endometriosis and three control women and added individually in the culture medium to conduct experimental and control eMSC sets, respectively...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28827999/high-carotenoid-production-by-a-halotolerant-bacterium-kocuria-sp-strain-qwt-12-and-anticancer-activity-of-its-carotenoid
#17
Sajad Sarvari, Faezeh Moakedi
Halophilic prokaryotes are extremophile microorganisms that grow optimally in media containing salts and almost appeared pigmented. Many of them contain high concentrations of carotenoids. Amongst 15 strains of halophilic prokaryotes isolated from industrial tannery wastewater in Qom, a Gram-stain-positive coccoid, aerobic, non-endospore-forming, halotolerant bacterium designated as strain QWT-12 showed high capacity in the production of carotenoids in a wide range of culture medium factors. 16S rRNA gene analysis showed that this strain belongs to the genus Kocuria...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28827998/molecular-cloning-and-characterization-of-protein-disulfide-isomerase-of-brugia-malayi-a-human-lymphatic-filarial-parasite
#18
Pravesh Verma, Pawan Kumar Doharey, Sunita Yadav, Ankur Omer, Poonam Singh, Jitendra Kumar Saxena
Lymphatic filariasis results in an altered lymphatic system and the abnormal enlargement of body parts, causing pain, serious disability and social stigma. Effective vaccines are still not available nowadays, drugs against the disease is required. Protein disulfide isomerase (PDI) is an essential catalyst of the endoplasmic reticulum which is involved in folding and chaperone activities in different biological systems. Here, we report the enzymatic characterization of a Brugia malayi Protein disulfide isomerase (BmPDI), which was expressed and purified from Escherichia coli BL21 (DE3)...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28827997/highlight-report-limits-of-prognostication-of-non-small-cell-lung-cancer
#19
EDITORIAL
Alshaimaa Adawy
No abstract text is available yet for this article.
2017: EXCLI journal
https://www.readbyqxmd.com/read/28827996/apigenin-7-o-glucoside-versus-apigenin-insight-into-the-modes-of-anticandidal-and-cytotoxic-actions
#20
Marija Smiljkovic, Danijela Stanisavljevic, Dejan Stojkovic, Isidora Petrovic, Jelena Marjanovic Vicentic, Jelena Popovic, Simona Golic Grdadolnik, Dejan Markovic, Snežana Sankovic-Babice, Jasmina Glamoclija, Milena Stevanovic, Marina Sokovic
Bioactive potential of apigenin derivative apigenin-7-O-glucoside related to its antifungal activity on Candida spp. and cytotoxic effect on colon cancer cells was studied and compared with bioactive potential of apigenin. Antifungal activity was tested on 14 different isolates of Candida spp. using membrane permeability assay, measuring inhibition of reactive oxidative species and inhibition of CYP51 C. albicans enzyme. Cytotoxic potential of apigenin-7-O-glucoside was tested on colon cancer HCT116 cells by measuring cell viability, apoptosis rate and apoptosis- and colon cancer-related gene expression...
2017: EXCLI journal
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