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EXCLI Journal

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https://www.readbyqxmd.com/read/29383021/micronucleus-cytome-assay-in-the-differential-assessment-of-cytotoxicity-and-genotoxicity-of-cadmium-and-lead-in-amietophrynus-regularis
#1
C G Alimba, A M Aladeyelu, I A Nwabisi, A A Bakare
Amphibians are increasingly being used as bio-indicator of contamination in ecosystems due to their sensitivity to xenobiotics in the environment. Cadmium and lead compounds, ubiquitous mutagens and carcinogens, are capable of eliciting genome instability in adult toads which may enhance amphibian decline. Micronucleus cytome (MN-cyt) assay, a comprehensive cytogenetic test for the assessment of genome instability induced by xenobiotics in organisms, was utilized in the differential cytogenotoxic evaluation of Cd and Pb in adult Amietophrynus regularis...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29383020/data-mining-for-the-identification-of-metabolic-syndrome-status
#2
REVIEW
Apilak Worachartcheewan, Nalini Schaduangrat, Virapong Prachayasittikul, Chanin Nantasenamat
Metabolic syndrome (MS) is a condition associated with metabolic abnormalities that are characterized by central obesity (e.g. waist circumference or body mass index), hypertension (e.g. systolic or diastolic blood pressure), hyperglycemia (e.g. fasting plasma glucose) and dyslipidemia (e.g. triglyceride and high-density lipoprotein cholesterol). It is also associated with the development of diabetes mellitus (DM) type 2 and cardiovascular disease (CVD). Therefore, the rapid identification of MS is required to prevent the occurrence of such diseases...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29383019/alteration-of-hepatocellular-antioxidant-gene-expression-pattern-and-biomarkers-of-oxidative-damage-in-diazinon-induced-acute-toxicity-in-wistar-rat-a-time-course-mechanistic-study
#3
Shokoufeh Hassani, Faheem Maqbool, Armin Salek-Maghsoudi, Soheila Rahmani, Amir Shadboorestan, Amir Nili-Ahmadabadi, Mohsen Amini, Parviz Norouzi, Mohammad Abdollahi
In the present survey, the plasma level of diazinon after acute exposure was measured by HPLC method at a time-course manner. In addition, the impact of diazinon on the expression of the key genes responsible for hepatocellular antioxidative defense, including PON1, GPx and CAT were investigated. The increase in oxidative damages in treated rats was determined by measuring LPO, protein carbonyl content and total antioxidant power in plasma. After administration of 85 mg/kg diazinon in ten groups of male Wistar rats at different time points between 0-24 hours, the activity of AChE enzyme was inhibited to about 77...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29383018/different-effects-of-metformin-and-insulin-on-primary-and-secondary-chemoprevention-of-colorectal-adenoma-in-diabetes-type-2-traditional-and-bayesian-meta-analysis
#4
Marjan Mansourian, Raheleh Karimi, Golnaz Vaseghi
Metformin and insulin differently affect the risk of colon cancer in type 2 diabetic patients, however their effects on colon adenoma is not clear. PubMed, ISI, Scopus and Cochrane databases were searched for studies reporting. The outcomes were total adenoma; advanced adenoma and recurrent adenoma. Traditional and Bayesian meta-analysis were conducted via random-effects models. Odds ratios (OR) with 95 % confidence intervals (CIs) / or credible intervals (CrI) were used to describe the ratio of different events...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29383017/highly-potent-antioxidant-olea-europaea-l-leaf-extract-affects-carotid-and-renal-haemodynamics-in-experimental-hypertension-the-role-of-oleuropein
#5
Milan Ivanov, Una-Jovana Vajic, Nevena Mihailovic-Stanojevic, Zoran Miloradovic, Djurdjica Jovovic, Jelica Grujic-Milanovic, Danijela Karanovic, Dragana Dekanski
Haemodynamic alterations in carotid and renal arteries are associated with the severity of target organ damage in patients with hypertension. Dietary habits, such as the Mediterranean diet, regulate blood pressure and oxidative stress, thus reduce the mortality rate due to cardiovascular diseases. In this study, our aim was to evaluate the reducing activity, antioxidant capacity and metal chelating ability of standardized Olea europaea L. leaf extract (OLE), and to test its (5, 25, 50 mg/kg) acute in vivo effects, as well as oleuropein's (OP, 10 mg/kg) on oxidative stress, carotid, renal and systemic haemodynamic parameters (blood pressure, heart rate, cardiac output, peripheral resistance) in spontaneously hypertensive rats (SHR)...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29383016/an-update-on-the-biological-and-pharmacological-activities-of-diosgenin
#6
Jae Kwang Kim, Sang Un Park
No abstract text is available yet for this article.
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29383015/protective-effects-of-hydrogen-sulfide-on-chronic-kidney-disease-by-reducing-oxidative-stress-inflammation-and-apoptosis
#7
Hassan Askari, Behjat Seifi, Mehri Kadkhodaee, Nima Sanadgol, Mohammed Elshiekh, Mina Ranjbaran, Parisa Ahghari
The current study aimed to examine the renoprotective effects of long-term treatment with sodium hydrosulfide (NaHS), a prominent hydrogen sulfide donor, in 5/6 nephrectomy animal model. Twenty-four rats were randomly divided into 3 groups including sham-operated group (Sham), 5/6-nephrectomized group (5/6 Nx), and NaHS-treated group (5/6Nx+NaHS). NaHS (30 micromol/l) was added twice daily into the drinking water and renal failure was induced by 5/6 nephrectomy. Twelve weeks after surgical procedure, blood pressure, creatinine clearance (CCr), urine concentration of neutrophil gelatinase associated lipocalin (NGAL) and tissue concentration of malondialdehyde (MDA), superoxide dismutase (SOD), as well as renal morphological changes, apoptosis (cleaved caspase-3) and inflammation (p-NF-κB) were measured...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29383014/association-between-single-nucleotide-polymorphisms-in-the-pi3k-akt-mtor-pathway-and-bladder-cancer-risk-in-a-sample-of-iranian-population
#8
Fatemeh Bizhani, Mohammad Hashemi, Hiva Danesh, Akbar Nouralizadeh, Behzad Narouie, Gholamreza Bahari, Saeid Ghavami
In the past few years several investigations have focused on the role of PI3K/AKT/mTOR pathway and its deregulations in different cancers. This study aimed to examine genetic polymorphisms of this pathway in bladder cancer (BC). In this case-control study, 235 patients with pathologically confirmed bladder cancer and 254 control subjects were examined. PIK3CA, AKT1 and mTOR variants were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The findings proposed that the PIK3CA rs6443624 SNP significantly decreased the risk of BC (OR=0...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29383013/the-jak2-v617f-mutation-in-isolated-neutropenia
#9
Stephen E Langabeer
No abstract text is available yet for this article.
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29333138/highlight-report-monitoring-cytochrome-p450-activities-in-living-hepatocytes
#10
EDITORIAL
Ahmed Ghallab
No abstract text is available yet for this article.
2017: EXCLI Journal
https://www.readbyqxmd.com/read/29333137/highlight-report-intratumoral-metabolomic-heterogeneity-of-breast-cancer
#11
EDITORIAL
Regina Stoeber
No abstract text is available yet for this article.
2017: EXCLI Journal
https://www.readbyqxmd.com/read/29333136/highlight-report-the-relationship-of-dna-copy-number-alterations-and-mrna-levels-in-cancer
#12
EDITORIAL
Seddik Hammad
No abstract text is available yet for this article.
2017: EXCLI Journal
https://www.readbyqxmd.com/read/29333135/highlight-report-metabolomics-in-hepatotoxicity-testing
#13
EDITORIAL
Ahmed Ghallab
No abstract text is available yet for this article.
2017: EXCLI Journal
https://www.readbyqxmd.com/read/29333134/highlight-report-the-pseudolobule-in-liver-fibrosis
#14
EDITORIAL
H M Bolt
No abstract text is available yet for this article.
2017: EXCLI Journal
https://www.readbyqxmd.com/read/29333133/highlight-report-occupational-urinary-bladder-cancer
#15
EDITORIAL
H M Bolt
No abstract text is available yet for this article.
2017: EXCLI Journal
https://www.readbyqxmd.com/read/29333132/detection-of-aflatoxin-producing-fungi-isolated-from-nile-tilapia-and-fish-feed
#16
Hams M A Mohamed, Walaa F A Emeish, Albert Braeuning, Seddik Hammad
Contamination of fish by fungi and their mycotoxins poses major health concerns to human and animals. Therefore, our study was aimed to investigate Aspergillus flavus (A. flavus) infections and the levels of aflatoxins in Nile tilapia, Oreochromis niloticus (O. niloticus) , and fish feed. Samples from O. niloticus and fish feed (n=25 for each) were randomly collected from private fish farms at Qena province, Egypt, during the winter season. Different Aspergillus spp. were detected in 60 % and 64 % of O. niloticus and fish feed, respectively...
2017: EXCLI Journal
https://www.readbyqxmd.com/read/29333131/mir-494-protects-pancreatic-%C3%AE-cell-function-by-targeting-pten-in-gestational-diabetes-mellitus
#17
Yanfang He, Jie Bai, Ping Liu, Jianxin Dong, Yajuan Tang, Jianli Zhou, Ping Han, Jun Xing, Yan Chen, Xiangyang Yu
Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications characterized by insulin resistance and pancreatic β-cell dysfunction. Increasing evidence suggests that microRNAs (miRNAs) play key roles in the diverse types of diabetes, including GDM. However, the underlying mechanisms remain largely unknown. The purpose of this study is to investigate the role of microRNAs in GDM. The microarray data of dysregulated miRNAs in blood and placenta was retrieved in the GEO dataset under the accession number GSE19649...
2017: EXCLI Journal
https://www.readbyqxmd.com/read/29333130/an-in-silico-approach-in-predicting-the-possible-mechanism-involving-restoration-of-wild-type-p53-functions-by-small-molecular-weight-compounds-in-tumor-cells-expressing-r273h-mutant-p53
#18
Ibrahim Malami, Aliyu Muhammad, Imaobong C Etti, Peter M Waziri, Alhassan M Alhassan
R273H mutant p53 is a DNA-contact mutant that renders p53 dysfunctional due to a single substitution of Arg273 for His273. Rescuing R273 mutant p53 implies that a competent molecule would have to bind to the site of DNA-contact hot spots to complement the loss of contact with the DNA-binding domain. Here, curcumin, flavokawain B, and alpinetin were docked against the crystal structure of R273H mutant p53 in silico . Consequently, all the compounds bind to the cavity of R273H mutant p53 with a dissociation constant estimated to have 36...
2017: EXCLI Journal
https://www.readbyqxmd.com/read/29333129/the-predictive-value-of-pre-and-post-induction-chemotherapy-plasma-ebv-dna-level-and-tumor-volume-for-the-radiosensitivity-of-locally-advanced-nasopharyngeal-carcinoma
#19
Yang Song, He Xiao, Zhenzhou Yang, Mingying Geng, Jungang Ma, Yujiang Ren, Yun Liu, Ge Wang
This study was dedicated to investigate the predictive value of pre- and post-induction chemotherapy plasma EBV (Epstein-Barr Virus) DNA level and tumor volume for the radiosensitivity of locally advanced NPC. 129 previously untreated locally advanced NPC patients were enrolled. Plasma EBV-DNA copy number and tumor volume was detected before and after induction chemotherapy. The tumor volume was also measured after radiotherapy. Among 129 patients, 98 were positive for EBV DNA. The residual gross target volume of the primary tumor (GTVnx) and GTVnd after radiotherapy was positively correlated with post-induction chemotherapy EBV copy number (rho=0...
2017: EXCLI Journal
https://www.readbyqxmd.com/read/29333128/-in-vitro-transfection-of-anti-tumor-mir-101-induces-bim-a-pro-apoptotic-protein-expression-in-acute-myeloid-leukemia-aml
#20
Narges Nikoonahad Lotfabadi, Homa Mohseni Kouchesfahani, Mohammad Hasan Sheikhha, Seyed Mehdi Kalantar
Acute myeloid leukemia (AML) frequently relapses after initial treatment, though it is possible that drug resistance occurs. Hence, it seems necessary to develop novel therapies such as gene therapy specifically via miRNA transfection. MicroRNA-101 has been considered as a tumor suppressor in different types of cancer. It is demonstrated that exogenous miR-101 transfection is associated with decreased viability in AML in this paper. Besides, the increase of pro-apoptotic protein BIM expression in both mRNA and protein level has been illustrated...
2017: EXCLI Journal
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