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EXCLI Journal

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https://www.readbyqxmd.com/read/28275323/possibilities-and-limitations-of-intravital-imaging
#1
EDITORIAL
Reham Hassan
No abstract text is available yet for this article.
2016: EXCLI journal
https://www.readbyqxmd.com/read/28275322/pathophysiology-of-cholestatic-liver-disease-and-its-relevance-for-in-vitro-tests-of-hepatotoxicity
#2
EDITORIAL
Regina Stöber
No abstract text is available yet for this article.
2016: EXCLI journal
https://www.readbyqxmd.com/read/28275321/highlight-report-predicting-late-metastasis-in-breast-cancer
#3
EDITORIAL
Seddik Hammad, Gada S Osman, Mohamed Ezzeldien, Hassan Ahmed, Ahmed M Kotb
No abstract text is available yet for this article.
2016: EXCLI journal
https://www.readbyqxmd.com/read/28275320/isolation-and-cultivation-of-adult-primary-bovine-hepatocytes-from-abattoir-derived-liver
#4
Sonja Ehrhardt, Marion Schmicke
The aim was to establish a cell culture of adult primary bovine hepatocytes obtained from liver following slaughter and to cultivate the cells in a sandwich culture. Cells and medium samples were taken after separation of cells (day 0), during monolayer (days 1, 2 and 3) and during sandwich culture (days 1, 2, 3, 4, 7, 10 and 14). The mRNA expression of BAX, BCL2L, FAS, IGF-1 and GHR1A was measured as well as urea and LDH. Hepatocytes were obtained by using a two-step collagenase perfusion and were purified thereafter by density gradient centrifugation...
2016: EXCLI journal
https://www.readbyqxmd.com/read/28275319/comparison-of-melatonin-with-growth-factors-in-promoting-precursor-cells-proliferation-in-adult-mouse-subventricular-zone
#5
Areechun Sotthibundhu, Kasima Ekthuwapranee, Piyarat Govitrapong
Melatonin, secreted mainly by the pineal gland, plays roles in various physiological functions including protecting cell death. We showed in previous study that the proliferation and differentiation of precursor cells from the adult mouse subventricular zone (SVZ) can be modulated by melatonin via the MT1 melatonin receptor. Since melatonin and epidermal growth factor receptor (EGFR) share some signaling pathway components, we investigated whether melatonin can promote the proliferation of precursor cells from the adult mouse SVZ via the extracellular signal-regulated protein kinase /mitogen-activated protein kinase (ERK/MAPK) pathways in comparison with epidermal growth factor (EGF)...
2016: EXCLI journal
https://www.readbyqxmd.com/read/28096793/efficacy-of-antioxidant-in-idiopathic-pulmonary-fibrosis-a-systematic-review-and-meta-analysis
#6
REVIEW
Amit D Kandhare, Anwesha Mukherjee, Pinaki Ghosh, Subhash L Bodhankar
Idiopathic pulmonary fibrosis (IPF) is a chronic oxido-inflammatory disorder of the lung. Oxidative stress is widely recognized as a central feature of IPF. Antioxidant therapy has been proposed as an effective treatment for IPF. An array of clinical trials describing the therapeutic impact of these drugs have been reporting albeit with conflicting evidence points. We performed a meta-analysis of trials in which efficacy of antioxidant therapy was compared with control in IPF. Systematic literature search was conducted in PubMed, EMBASE, the Cochrane Library, CPCI-S (Conference Proceedings Citation Index-Science), ICTRP (International Clinical Trials Registry Platform), and Google Scholar till June 2016 by two independent researchers...
2016: EXCLI journal
https://www.readbyqxmd.com/read/28096792/first-reported-case-of-haemoglobin-m-hyde-park-in-a-malay-family-living-in-malaysia
#7
Tang Yee Loong, Doris Lau Sie Chong, A Rahman A Jamal, Nor Azian Abdul Murad, Raja Zahratul Azma Raja Sabudin, Leong Chooi Fun
Haemoglobin (Hb)-M Hyde Park, also known as Hb-M Akita is a rare type of hereditary Hb M due to autosomal dominant mutation of CAC>TAC on codon 92 of β globin gene resulting in the replacement of histidine by tyrosine on β globin chain. This variant Hb has a tendency to form methaemoglobin (metHb). The iron ion in metHb is oxidized to ferric (Fe3+) which is unable to carry oxygen and the patients manifest as cyanosis clinically. A 9-year-old Malay girl was incidentally found to be cyanotic when she presented to a health clinic...
2016: EXCLI journal
https://www.readbyqxmd.com/read/28096791/physicochemical-analyses-of-a-bioactive-4-aminoantipyrine-analogue-synthesis-crystal-structure-solid-state-interactions-antibacterial-conformational-and-docking-studies
#8
Mohammad Sayed Alam, Dong-Ung Lee
A novel Schiff base derivative of 4-aminoantipyrine, that is, (E)-4-(2-methoxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (MBA-dMPP), was synthesized and characterized by FT-IR, (1)H-NMR, and EI-MS. Single-crystal X-ray diffraction data revealed MBA-dMPP adopts a trans configuration around its central C=N double bond, and forms orthorhombic crystals. XRD revealed that MBA-dMPP possess two different planes, in which the pyrazolone and benzylidene groups attached to C9 of the pyrazolone ring are almost coplanar and the phenyl ring connected to the N1 atom of the pyrazolone moiety lies in another plane...
2016: EXCLI journal
https://www.readbyqxmd.com/read/28096790/isolation-characterization-and-hypolipidemic-activity-of-ferulic-acid-in-high-fat-diet-induced-hyperlipidemia-in-laboratory-rats
#9
Pankaj G Jain, Sanjay J Surana
Prosopis cineraria (L.) Druce (Leguminosae) (syn. Prosopis spicigera L.) has antidiabetic and antioxidant potential. Earlier we reported its hypolipidemic activity obtained from ethanol extract (ET-PCF). Object of this work was to isolate ferulic acid (FA) from ET-PCF and evaluate hypolipidemic activity against high-fat diet (HFD)-induced hyperlipidemic laboratory rats. ET-PCF was subjected to flash column chromatography to isolate FA. The chemical structure of the isolated compound was elucidated by UV, IR, (1)H NMR,(13)C NMR and LC-MS...
2016: EXCLI journal
https://www.readbyqxmd.com/read/28096789/genotoxic-and-cytotoxic-action-potential-of-terminalia-citrina-a-medicinal-plant-of-ethnopharmacological-significance
#10
Muhammad Furqan Akhtar, Ammara Saleem, Ali Sharif, Bushra Akhtar, Maaz Bin Nasim, Sohaib Peerzada, Moosa Raza, Hira Ijaz, Shoaib Ahmed, Maryam Shabbir, Sajid Ali, Zeeshan Akbar, Syed Saeed Ul Hassan
Most herbal medicines utilized in complementary and alternative medicine lack safety evaluation setting our lives under unwarranted risks. Present study comprised of genotoxic and cytotoxic appraisal of Terminalia citrina fruits which are used as a folklore medicine for treatment of various ailments. Aqueous and ethanolic extracts of T. citrina fruit extracts were evaluated for the presence of different phytochemicals. Genotoxic potential of both the extract of T. citrina was assessed through Ames reverse mutagenicity assay in Salmonella TA 100 and 102 strains...
2016: EXCLI journal
https://www.readbyqxmd.com/read/28096788/current-trends-in-the-treatment-of-hepatitis-c-interventions-to-avoid-adverse-effects-and-increase-effectiveness-of-anti-hcv-drugs
#11
REVIEW
Ammara Saleem, Muhammad Furqan Akhtar, Muhammed Fahd Mushtaq, Muhammad Saleem, Syed Taqi Muhammad, Bushra Akhtar, Ali Sharif, Sohaib Peerzada
Viral hepatitis, an inflammatory liver disease, is caused by various genotypes of hepatitis C viruses (HCV). Hepatitis C slowly sprouts into fibrosis, which progresses to cirrhosis. Over a prolonged period of time compensated cirrhosis can advance to decompensated cirrhosis culminating in hepatic failure and death. Conventional treatment of HCV involves the administration of interferons. However, association of interferon with the adverse drug reactions led to the development of novel anti-HCV drugs given as monotherapy or in combination with the other drugs...
2016: EXCLI journal
https://www.readbyqxmd.com/read/28096787/current-potential-health-benefits-of-sulforaphane
#12
Jae Kwang Kim, Sang Un Park
No abstract text is available yet for this article.
2016: EXCLI journal
https://www.readbyqxmd.com/read/28096786/apple-as-a-source-of-dietary-phytonutrients-an-update-on-the-potential-health-benefits-of-apple
#13
Tae Kyung Hyun, Keum-Il Jang
No abstract text is available yet for this article.
2016: EXCLI journal
https://www.readbyqxmd.com/read/28096785/nutrients-as-novel-therapeutic-approaches-for-metabolic-disturbances-in-polycystic-ovary-syndrome
#14
REVIEW
Asieh Mansour, Saeed Hosseini, Bagher Larijani, Mohammad Reza Mohajeri-Tehrani
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women. This disease is characterized by infertility, menstrual dysfunction, and hyperandrogenism. Also, PCOS is often associated with hyperlipidemia and impaired glucose tolerance, conditions that are associated with cardiovascular disorder, type 2 diabetes, cancer and hypertension. Evidence supports that some nutrients may affect the hormonal and metabolic disturbances of PCOS. Here in this study, we aimed to review the available literature that assessed the nutrients such as inostol, isoflavonids, resveratrol, vitamin D, and PUFA (polyunsaturated fatty acids), known to influence the hormonal and metabolic disturbances of PCOS, along with the strategies and future directions of nutrient supplementations in such patients...
2016: EXCLI journal
https://www.readbyqxmd.com/read/28096784/segmenting-breast-cancerous-regions-in-thermal-images-using-fuzzy-active-contours
#15
Hossein Ghayoumi Zadeh, Javad Haddadnia, Omid Rahmani Seryasat, Sayed Mohammad Mostafavi Isfahani
Breast cancer is the main cause of death among young women in developing countries. The human body temperature carries critical medical information related to the overall body status. Abnormal rise in total and regional body temperature is a natural symptom in diagnosing many diseases. Thermal imaging (Thermography) utilizes infrared beams which are fast, non-invasive, and non-contact and the output created images by this technique are flexible and useful to monitor the temperature of the human body. In some clinical studies and biopsy tests, it is necessary for the clinician to know the extent of the cancerous area...
2016: EXCLI journal
https://www.readbyqxmd.com/read/28096783/quantification-of-rutin-in-rat-s-brain-by-uhplc-esi-q-tof-ms-ms-after-intranasal-administration-of-rutin-loaded-chitosan-nanoparticles
#16
Niyaz Ahmad, Rizwan Ahmad, Atta Abbas Naqvi, Md Aftab Alam, Mohd Samim, Zeenat Iqbal, Farhan Jalees Ahmad
Rutin (RT), an antioxidant drug, has been utilized to treat cerebral ischemia hence a sensitive quantification method for estimation of RT in brain homogenate is necessary to develop. This study aims to prepare RT loaded Chitosan Nanoparticles (RT-CS-NPs) develop and validate ultra-high performance liquid chromatography-electrospray ionization-synapt mass spectrometric method Synapt Mass Spectrometry (Synapt MS) (UHPLC/ESI-QTOF-MS/MS) for quantification of RT in brain homogenate from Wistar rat. The process of chromatographic separation was carried out on Waters ACQUITY UPLC™ with the components of separation in detail as; column: BEH C-18 with dimension as 2...
2016: EXCLI journal
https://www.readbyqxmd.com/read/28096782/automatic-liver-segmentation-on-computed-tomography-using-random-walkers-for-treatment-planning
#17
Mehrdad Moghbel, Syamsiah Mashohor, Rozi Mahmud, M Iqbal Bin Saripan
Segmentation of the liver from Computed Tomography (CT) volumes plays an important role during the choice of treatment strategies for liver diseases. Despite lots of attention, liver segmentation remains a challenging task due to the lack of visible edges on most boundaries of the liver coupled with high variability of both intensity patterns and anatomical appearances with all these difficulties becoming more prominent in pathological livers. To achieve a more accurate segmentation, a random walker based framework is proposed that can segment contrast-enhanced livers CT images with great accuracy and speed...
2016: EXCLI journal
https://www.readbyqxmd.com/read/27932940/retraction-the-improvement-of-large-high-density-lipoprotein-hdl-particle-levels-and-presumably-hdl-metabolism-depend-on-effects-of-low-carbohydrate-diet-and-weight-loss
#18
C Finelli, P Crispino, S Gioia, N La Sala, L D'amico, M La Grotta, O Miro, D Colarusso
[This retracts the article DOI: 10.17179/excli2015-642.].
2016: EXCLI journal
https://www.readbyqxmd.com/read/27822176/ferulic-acid-ameliorates-tnbs-induced-ulcerative-colitis-through-modulation-of-cytokines-oxidative-stress-inos-cox-2-and-apoptosis-in-laboratory-rats
#19
Smeeta S Sadar, Niraj S Vyawahare, Subhash L Bodhankar
Ulcerative colitis (UC) is a chronic immune-inflammatory disorder characterized by oxido-nitrosative stress, the release of pro-inflammatory cytokines and apoptosis. Ferulic acid (FA), a phenolic compound is considered to possess potent antioxidant, anti-apoptotic and anti-inflammatory activities. The aim is to evaluate possible mechanism of action of FA against trinitrobenzensulfonic acid (TNBS) induced ulcerative colitis (UC) in rats. UC was induced in Sprague-Dawley rats (150-200 g) by intrarectal administration of TNBS (100 mg/kg)...
2016: EXCLI journal
https://www.readbyqxmd.com/read/27822175/keyhole-limpet-hemocyanin-induces-innate-immunity-via-syk-and-erk-phosphorylation
#20
Kyoko Yasuda, Hideki Ushio
Hemocyanin is an extracellular respiratory protein containing copper in hemolymph of invertebrates, such as Mollusk and Arthropod. Keyhole limpet hemocyanin (KLH) is one of hemocyanins and has many years of experience for vaccine developments and immunological studies in mammals including human. However, the association between KLH and the immune systems, especially the innate immune systems, remains poorly understood. The aim of this study is to clarify the direct effects of KLH on the innate immune systems...
2016: EXCLI journal
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