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EXCLI Journal

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https://www.readbyqxmd.com/read/30233286/regenerative-potential-of-partially-differentiated-mesenchymal-stromal-cells-in-a-mouse-model-of-a-full-thickness-skin-wound
#1
Ausra Liubaviciute, Vytautas Kaseta, Aida Vaitkuviene, Zygmunt Mackiewicz, Gene Biziuleviciene
Mesenchymal stromal cells (MSCs, known as mesenchymal stem cells) are considered to be a promising therapeutic tool for many diseases. But it is still unclear which cells are more efficient and safe for wound healing and tissue regeneration for clinical applications: undifferentiated, partially differentiated stem cells or differentiated cells. In this study, we modified MSCs with keratinocyte-conditioned medium (KCM) and examined MSCs, partially differentiated MSCs (PMSCs) and differentiated cell migration, accumulation in the wounded area as well as cell regenerative efficiency in a full-thickness skin wound model...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30233285/effect-of-elaidic-acid-on-abca1-expression-in-raw-264-7-cells-is-it-through-ppar-gamma
#2
Hossein Montakhab-Yeganeh, Hossein Babaahmadi-Rezaei, Mahmood Doosti
In recent years, Trans Fatty Acids have shown a strong correlation with cardiovascular disease. However, the mechanisms explaining their atherogenicity are still unclear. ABCA1, which is involved in the reverse cholesterol transport pathway, has been considered as a new therapeutic target for cardiovascular disease. In vitro studies of the effects of PPAR-γ on lipid homeostasis in macrophage cells suggested a role for PPAR-γ in the regulation of ABCA1-dependent cholesterol efflux to apoA-I pathway. Thus, in this study we examined the effect of elaidic acid (EA) as the most abundant TFA on expression of ABCA1 and PPAR-γ in RAW 264...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30233284/quercetin-and-its-role-in-biological-functions-an-updated-review
#3
Jae Kwang Kim, Sang Un Park
No abstract text is available yet for this article.
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30233283/-arg1-single-nucleotide-polymorphisms-rs2781666-and-rs2781665-confer-risk-of-type-2-diabetes-mellitus
#4
Syed Fawad Ali Shah, Tahir Iqbal, Nasreen Naveed, Sumaira Akram, Muhammad Arshad Rafiq, Sabir Hussain
Genetic polymorphisms mapped in the ARG1 locus (chr6:131894344-131905472) and their functional effects on type 2 diabetes mellitus (T2DM) have not been thoroughly elucidated to date. The present study aimed to investigate an association between variant alleles at ARG1 locus and T2DM in patients. Two ARG1 single nucleotide polymorphisms (SNPs) were characterized in a representative sample of 500 patients with T2DM and 500 healthy volunteers. Serum lipid profile was studied by spectrophotometric analysis, while serum arginase-1 concentrations were determined by an enzyme-linked immunosorbent assay...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30233282/repositioning-of-8-hydroxyquinoline-derivatives-as-a-new-promising-candidate-for-combating-multidrug-resistant-neisseria-gonorrhoeae
#5
Ratana Lawung, Rungrot Cherdtrakulkiat, Sunanta Nabu, Supaluk Prachayasittikul, Chartchalerm Isarankura-Na-Ayudhya, Virapong Prachayasittikul
The multidrug resistance of Neisseria gonorrhoeae becomes a public health problem worldwide, especially the strain H041 that showed the decrease susceptibility to ceftriaxone which is the last resort for gonorrhea treatment. Therefore, the simultaneous discovery and development of a new compound to fight this pathogen is urgently required. In this study, 8-hydroxyquinoline (8HQ) and derivatives were evaluated for their antimicrobial activities against the gonococcal pathogen using spectinomycin as the reference drug...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30233281/investigating-the-role-of-p38-jnk-and-erk-in-lps-induced-hippocampal-insulin-resistance-and-spatial-memory-impairment-effects-of-insulin-treatment
#6
Parisa Iloun, Zahra Abbasnejad, Mahyar Janahmadi, Abolhassan Ahmadiani, Rasoul Ghasemi
Despite the consensus that neuro-inflammation and insulin resistance (IR) are two hallmarks of Alzheimer disease (AD), the molecular mechanisms responsible for the development of IR remain uncharacterized. MAPKs are signaling molecules that are implicated in the pathology of AD and have a role in IR development. Given that inflammatory mediators are shown to interfere with insulin signaling pathway in different cell types, the present work aimed to investigate whether neuro-inflammation induced memory loss is associated with hippocampal IR and whether insulin treatment protects against this IR...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30233280/occupational-stress-among-nurses-and-pre-hospital-emergency-staff-application-of-fuzzy-analytic-hierarchy-process-fahp-method
#7
Fazel Rajabi, Mehdi Jahangiri, Hossein Molaeifar, Marzieh Honarbakhsh, Payam Farhadi
Healthcare professionals, especially nurses and pre-hospital emergency (PHE) staff, are influenced by many stressors due to their responsibility to provide comfort as well as care and treatment of patients. The aim of the present study was to identify and rank the occupational stressors in nurses and PHE staff using Fuzzy Analytic Hierarchy Process (FAHP) method. In this cross-sectional study, occupational stress factors in nurses and PHE staffs were identified and ranked by 30 experts, using FAHP method. Occupational stress factors were collected by General Health Questionnaire (GHQ), Job Stress Questionnaires as well as a literature review...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30233279/non-random-distribution-of-gastric-cancer-susceptible-loci-on-human-chromosomes
#8
Ghazale Mahjoub, Mostafa Saadat
No abstract text is available yet for this article.
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30233278/glyphosate-toxicity-and-carcinogenicity
#9
Tomoyuki Kawada
No abstract text is available yet for this article.
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30233277/ellman-s-method-is-still-an-appropriate-method-for-measurement-of-cholinesterases-activities
#10
Seyed Vahid Shetab-Boushehri
No abstract text is available yet for this article.
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30190669/red-and-processed-meat-and-risk-of-colorectal-cancer-an-update
#11
Bachir Benarba
No abstract text is available yet for this article.
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30190668/derivation-of-indoor-air-guidance-values-for-volatile-organic-compounds-voc-emitted-from-polyurethane-flexible-foam-voc-with-repeated-dose-toxicity-data
#12
Thomas Schupp
Polyurethane Flexible Foams (PUF) are versatile materials used in upholstered furniture and bed mattresses. Due to the production procedure, fresh foams emit volatile organic compounds (VOC). Chamber tests issued by the European association of flexible polyurethane foam blocks manufacturers (EUROPUR) revealed certain levels of VOCs, and the emission rates are declining over time. To assess the risk associated to these VOCs which, as a consequence, might be detectable in indoor air where these PUF are used. To evaluate the risk for consumers, their concentration can be matched against existing benchmarks for indoor air...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30190667/anti-inflammation-effects-of-8-oxo-9-octadecenoic-acid-isolated-from-undaria-peterseniana-in-lipopolysaccharide-stimulated-macrophage-cells
#13
Min-Cheol Kang, Young-Min Ham, Soo-Jin Heo, Seon-A Yoon, Su-Hyeon Cho, Seung-Hae Kwon, Myeong Seon Jeong, You-Jin Jeon, Kka Sanjeewa, Weon-Jong Yoon, Kil-Nam Kim
The aim of this study was to investigate the anti-inflammatory activity of 8-oxo-9-octadecenoic acid (OOA) isolated from Undaria peterseniana by examining its ability to inhibit the lipopolysaccharide (LPS)-induced production of inflammatory mediators in RAW 264.7 macrophage cells. We found that OOA significantly suppressed the LPS-induced production of nitric oxide (NO) and inflammatory cytokines. OOA downregulated the LPS-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 proteins...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30190666/the-cardiac-niche-role-in-cardiomyocyte-differentiation-of-rat-bone-marrow-derived-stromal-cells-comparison-between-static-and-microfluidic-cell-culture-methods
#14
Seyed Ahmad Vaez, Somayeh Ebrahimi-Barough, Masoud Soleimani, Sedighe Kolivand, Saeed Farzamfar, Seyed Hossein Ahmadi Tafti, Mahmoud Azami, Farshid Noorbakhsh, Jafar Ai
Due to the restricted potential of the heart to regenerate its damaged region, stem cell therapy is a promising treatment modality for myocardial infarction. It has been shown that incubation of bone marrow-derived stromal cells (BMSCs) with initial steps of cardiac differentiation in vitro , can have a significant effect on their therapeutic potential to treat myocardial infarction. Based on these well-established principals we were encouraged to study the direct co-culture of rat BMSCs with neonatal mouse almost pure cardiomyocytes (APCs) and cardiac niche cells (CNCs) in static 2D and microfluidic cell culture systems...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30190665/18-beta-glycyrrhetinic-acid-ameliorates-the-cognitive-functions-and-decreases-the-recurrence-rate-of-pituitary-adenomas-patients
#15
Xianxiang Wang, Yiquan Zhang, Jin Xiao, Ke Zhang, Qingxin Li, Hongwei Chen, Fei Liu
Pituitary adenomas, the most common tumors of all intracranial neoplasms, may cause either symptoms of mass effect or symptoms of hormone abnormal production. Besides physical damages, patients with pituitary adenomas always suffer from cognitive impairments, mainly in memory and executive functions. 18 beta-glycyrrhetinic acid (GA) has been found to exhibit anti-tumor effects in rat pituitary adenoma-derived cells. The aim of this paper was to investigate the effect of GA in postoperative clinical application...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30190664/unraveling-the-bioactivity-of-anticancer-peptides-as-deduced-from-machine-learning
#16
REVIEW
Watshara Shoombuatong, Nalini Schaduangrat, Chanin Nantasenamat
Cancer imposes a global health burden as it represents one of the leading causes of morbidity and mortality while also giving rise to significant economic burden owing to the associated expenditures for its monitoring and treatment. In spite of advancements in cancer therapy, the low success rate and recurrence of tumor has necessitated the ongoing search for new therapeutic agents. Aside from drugs based on small molecules and protein-based biopharmaceuticals, there has been an intense effort geared towards the development of peptide-based therapeutics owing to its favorable and intrinsic properties of being relatively small, highly selective, potent, safe and low in production costs...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30190663/prevalence-of-self-reported-work-related-illness-and-injuries-among-building-construction-workers-shiraz-iran
#17
Milad Derakhshan Jazari, Mehdi Jahangiri, Hamed Khaleghi, Narges Abbasi, Soheil Hassanipour, Mahnaz Shakerian, Mojtaba Kamalinia
The construction industry is one of the largest and most hazardous industries in the world, which has a direct role in the development of countries. The purpose of this study was to investigate the prevalence of self-reported work-related illness and injuries among construction workers in Shiraz, Iran. 850 randomly selected workers from 2450 construction sites completed a self-statement questionnaire regarding the prevalence of self-reported work-related illness and injuries (WRIIs), in Shiraz, Iran. The association of WRII with demographic variables were studied...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30190662/highlight-report-diploptera-functata-cockroach-milk-as-next-superfood
#18
EDITORIAL
Kamal Niaz, Elizabeta Zaplatic, Jonathan Spoor
No abstract text is available yet for this article.
2018: EXCLI Journal
https://www.readbyqxmd.com/read/30190661/is-autophagy-associated-with-diabetes-mellitus-and-its-complications-a-review
#19
REVIEW
Debalina Bhattacharya, Mainak Mukhopadhyay, Maitree Bhattacharyya, Parimal Karmakar
Diabetes mellitus (DM) is an endocrine disorder. In coming decades it will be one of the leading causes of death globally. The key factors in the pathogenesis of diabetes are cellular injuries and disorders of energy metabolism leading to severe diabetic complications. Recent studies have confirmed that autophagy plays a pivotal role in diabetes and its complications. It has been observed that autophagy regulates the normal function of pancreatic β cells and insulin-target tissues, such as skeletal muscle, liver, and adipose tissue...
2018: EXCLI journal
https://www.readbyqxmd.com/read/30190660/towards-understanding-aromatase-inhibitory-activity-via-qsar-modeling
#20
REVIEW
Watshara Shoombuatong, Nalini Schaduangrat, Chanin Nantasenamat
Aromatase is a rate-limiting enzyme for estrogen biosynthesis that is overproduced in breast cancer tissue. To block the growth of breast tumors, aromatase inhibitors (AIs) are employed to bind and inhibit aromatase in order to lower the amount of estrogen produced in the body. Although a number of synthetic aromatase inhibitors have been released for clinical use in the treatment of hormone-receptor positive breast cancer, these inhibitors may lead to undesirable side effects (e.g. increased rash, diarrhea and vomiting; effects on the bone, brain and heart) and therefore, the search for novel AIs continues...
2018: EXCLI Journal
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