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EXCLI Journal

Sadaf Mushtaq, Bilal Haider Abbasi, Bushra Uzair, Rashda Abbasi
Since ancient times, natural products from plants, animals, microbial and marine sources have been exploited for treatment of several diseases. The knowledge of our ancestors is the base of modern drug discovery process. However, due to the presence of extensive biodiversity in natural sources, the percentage of secondary metabolites screened for bioactivity is low. This review aims to provide a brief overview of historically significant natural therapeutic agents along with some current potential drug candidates...
2018: EXCLI Journal
Wenbin Li, Amit D Kandhare, Anwesha A Mukherjee, Subhash L Bodhankar
Background: Delayed wound healing is a diverse, multifactorial, complex and inter-related complication of diabetes resulting in significant clinical morbidity. Hesperidin possesses potent antidiabetic and wound healing activity. Aim: To evaluate the potential of hesperidin against experimentally induced diabetes foot ulcers. Methods: Diabetes was induced experimentally by streptozotocin (STZ, 55 mg/kg, i.p.) in Sprague Dawley rats (180-220 g) and wounds were created on the dorsal surface of the hind paw of rats...
2018: EXCLI Journal
Pelin Mutlu, Serap Yalçin Azarkan, Negar Taghavi Pourianazar, Meral Yücel, Ufuk Gündüz
Activation of the Wnt signaling in some types of cancer and its relation with chemotherapy resistance is a very interesting issue that has been emphasized in recent years. Although, it is known that increase in the activity of β-catenin is important in blast transformation and drug resistance, the underlying mechanisms are still unclear. In this study, changes in the expression levels of 186 genes that are thought to be important in drug resistance and Wnt signaling pathways were determined by using qPCR method in doxorubicin-sensitive and -resistant HeLa and K562 cell lines...
2018: EXCLI Journal
Matthias Jäger
Measures of human physical capacity are required in ergonomic work design. To avoid biomechanical low-back overload, criteria are needed to differentiate load and overload. With respect to the evaluation of manual materials handling and similar physical exposures regarding potential overload, the compression component of the forces transferred via lumbar discs or vertebrae are compared with the ultimate compressive strength of lumbar-spine segments in a common biomechanical approach. As mechanical load-bearing capacity cannot be quantified directly in vivo , forces are applied to dissected spinal elements up to failure, which is interpreted as a measure of ultimate strength or tolerance to compression...
2018: EXCLI Journal
Saeid Yaripour, Ali Mohammadi, Isa Esfanjani, Roderick B Walker, Saeed Nojavan
In this study, for the first time, an electro-driven microextraction method named electromembrane extraction combined with a simple high performance liquid chromatography and ultraviolet detection was developed and validated for the quantitation of zolpidem in biological samples. Parameters influencing electromembrane extraction were evaluated and optimized. The membrane consisted of 2-ethylhexanol immobilized in the pores of a hollow fiber. As a driving force, a 150 V electric field was applied to facilitate the analyte migration from the sample matrix to an acceptor solution through a supported liquid membrane...
2018: EXCLI Journal
Chadinee Thippakorn, Nalini Schaduangrat, Chanin Nantasenamat
Diabetes is associated with numerous metabolic and vascular risk factors that contribute to a high rate of micro-vascular and macro-vascular disorders leading to mortality and morbidity from diabetic complications. In this case, the major cause of death in overall diabetic patients results from diabetic nephropathy (DN) or renal failure. The risk factors and mechanisms that correspond to the development of DN are not fully understood and so far, no specific and sufficient diagnostic biomarkers are currently available other than micro- or macroalbuminuria...
2018: EXCLI Journal
Tahmeena Khan, Iqbal Azad, Rumana Ahmad, Saman Raza, Shalini Dixit, Seema Joshi, Abdul Rahman Khan
Mixed-ligand metal (II) (M=Cu, Fe, Co and Zn) complexes containing 2-butanone thiosemicarbazone and 1, 10-phenanthroline have been synthesized and characterized by melting point, FT-IR, 1 H-NMR, UV-spectrophotometry and molar conductance measurements. All the complexes were soluble in DMSO and DMF. They were thermally stable with high melting points. The computational studies of the complexes were also performed to assess toxicity potential, bioactivity score prediction and drug likeliness assessment based on various drug filters...
2018: EXCLI Journal
Hu Li, Xueping Zhang, Mingfu Chen, Jianyan Chen, Tao Gao, Shanglong Yao
NOD-like receptor 3 (NLRP3) plays critical roles in the initiation of inflammasome-mediated inflammation in microglia, thus becomes an important therapeutic target of Alzheimer's disease (AD). Dexmedetomidine (Dex), a new type of clinical anesthetic agent, shows anti-inflammatory properties and inhibits postoperative cognitive dysfunction in AD patients. The present study was aimed to investigate effect of Dex on NLRP3 activity in activated microglia and reveal the underlying mechanisms. The human microglia clone 3 (HMC3) cells were exposed to 100 ng/ml LPS and 5 mM ATP, in the presence and absence of doses of Dex...
2018: EXCLI Journal
Vladimir Z Ajdžanovic, Svetlana Trifunovic, Dragana Miljic, Branka Šošic-Jurjevic, Branko Filipovic, Marko Miler, Nataša Ristic, Milica Manojlovic-Stojanoski, Verica Miloševic
The pathological phenomenon of somatopause, noticeable in hypogonadal ageing subjects, is based on the growth hormone (GH) production and secretion decrease along with the fall in GH binding protein and insulin-like growth factor 1 (IGF-1) levels, causing different musculoskeletal, metabolic and mental issues. From the perspective of safety and efficacy, GH treatment is considered to be highly controversial, while some other therapeutic approaches (application of IGF-1, GH secretagogues, gonadal steroids, cholinesterase-inhibitors or various combinations) exhibit more or less pronounced weaknesses in this respect...
2018: EXCLI journal
Kamal Niaz, Elizabeta Zaplatic, Jonathan Spoor
No abstract text is available yet for this article.
2018: EXCLI Journal
Niraj Kumar Srivastava, Shikha Sharma, Rajkumar Sharma, Neeraj Sinha, Sudhir Kumar Mandal, Deepak Sharma
Rheumatoid arthritis (RA) is a systemic autoimmune disease whose major characteristics persistent joint inflammation that results in joint destruction and failure of the function. Collagen-induced arthritis (CIA) rat is an autoimmune disease model and in many ways shares features with RA. The CIA is associated with systemic manifestations, including alterations in the metabolism. Nuclear magnetic resonance (NMR) spectroscopy-based metabolomics has been successfully applied to the perchloric acid extract of the joint tissue of CIA rat and control rat for the analysis of aqueous metabolites...
2018: EXCLI Journal
Stefanie Hessel-Pras, Anke Ehlers, Albert Braeuning, Alfonso Lampen
The epithelium of the small intestine plays an important role in detoxification processes due to the presence of various xenobiotic-metabolizing enzymes from phase I and II, as well as transport proteins of the ATP-binding cassette superfamily. Exposure to xenobiotics induces the expression of these proteins in the small intestine, with multiple signaling pathways stimulated by exogenous compounds converging at individual gene promoters by mechanisms which have not been fully understood yet. In this context the promoter region of the CYP1A1 gene, encoding the phase I monooxygenase cytochrome P450 1A1, was analyzed by chromatin immunoprecipitation with regard to binding of xeno-sensing receptors following stimulation of Caco-2 cells with agonists of the aryl hydrocarbon receptor (AHR) and retinoid receptors...
2018: EXCLI Journal
Arfaa Sajid, Qaisar Manzoor, Munawar Iqbal, Amit Kumar Tyagi, Raja Adil Sarfraz, Anam Sajid
The present study was conducted to appraise the anticancer activity of Pinus roxburghii essential oil along with chemical composition evaluation. MTT assay revealed cytotoxicity induction in colon, leukemia, multiple myeloma, pancreatic, head and neck and lung cancer cells exposed to essential oil. Cancer cell death was also observed through live/dead cell viability assay and FACS analysis. Apoptosis induced by essential oil was confirmed by cleavage of PARP and caspase-3 that suppressed the colony-forming ability of tumor cells and 50 % inhibition occurred at a dose of 25 μg/mL...
2018: EXCLI Journal
Manel Gargouri, Ahlem Soussi, Amel Akrouti, Christian Magné, Abdelfattah El Feki
Our experimental work was aimed at evaluating the safety and protective effects of dietary spirulina supplementation on the kidney of newborn rats, the offspring of lead contaminated lactating mothers. Female rats were randomly divided into four groups: group I (control) was given a normal diet, group II (positive control, S) received a diet enriched with spirulina , group III received only lead through drinking water (Pb), and group IV received both a diet enriched with spirulina and lead contaminated water (S Pb)...
2018: EXCLI journal
Gaurav Gupta, Juhi Tiwari, Rajiv Dahiya, Rakesh Kumar Sharma, Anurag Mishra, Kamal Dua
No abstract text is available yet for this article.
2018: EXCLI Journal
Imen M'rad, Mustapha Jeljeli, Naima Rihane, Pascal Hilber, Mohsen Sakly, Salem Amara
Recently, the biosafety and potential influences of nanoparticles on central nervous system have received more attention. In the present study, we assessed the effect of aluminium oxide nanoparticles (Al2 O3 -NPs) on spatial cognition. Male Wistar rats were intravenously administered Al2 O3 -NP suspension (20 mg/kg body weight/day) for four consecutive days, after which they were assessed. The results indicated that Al2 O3 -NPs impaired spatial learning and memory ability. An increment in malondialdehyde levels with a concomitant decrease in superoxide dismutase activity confirmed the induction of oxidative stress in the hippocampus...
2018: EXCLI Journal
Meng-Fei Lau, Shalini Vellasamy, Kek-Heng Chua, Vikineswary Sabaratnam, Umah Rani Kuppusamy
Colorectal cancer (CRC) is the third most leading cause of morbidity and mortality throughout the world. 5-fluorouracil (5-FU), which is often administrated to disrupt carcinogenesis, was found to elevate blood glucose level among CRC patients. Thus, this study was conducted to evaluate the influence of rosiglitazone on antiproliferative effect of 5-FU using cellular model. Two human colonic carcinoma cell lines (HCT 116 and HT 29) were cultured in the presence of 5-FU, rosiglitazone or in combination under normal and high glucose concentration...
2018: EXCLI Journal
Jae Kwang Kim, Sang Un Park
No abstract text is available yet for this article.
2018: EXCLI Journal
Hira Saleem, Arooma Maryam, Saleem Ahmed Bokhari, Ayesha Ashiq, Sadaf Abdul Rauf, Rana Rehan Khalid, Fahim Ashraf Qureshi, Abdul Rauf Siddiqi
This study reports three novel sulfonamide derivatives 4-Chloro-N-[(4-methylphenyl) sulphonyl]-N-propyl benzamide ( 1A ), N-(2-hydroxyphenyl)-4-methyl benzene sulfonamide ( 1B ) and 4-methyl-N-(2-nitrophenyl) benzene sulfonamide ( 1C ). The compounds were synthesised from starting material 4-methylbenzenesulfonyl chloride and their structure was studied through 1 H-NMR and 13 C-NMR spectra. Computational docking was performed to estimate their binding energy against bacterial p -amino benzoic acid (PABA) receptor, the dihydropteroate synthase (DHPS)...
2018: EXCLI Journal
Jafar Nouri Nojadeh, Shahin Behrouz Sharif, Ebrahim Sakhinia
Colorectal cancer (CRC) is a heterogeneous disease that is caused by the interaction of genetic and environmental factors. Although it is one of the most common cancers worldwide, CRC would be one of the most curable cancers if it is detected in the early stages. Molecular changes that occur in colorectal cancer may be categorized into three main groups: 1) Chromosomal Instability (CIN), 2) Microsatellite Instability (MSI), and 3) CpG Island Methylator phenotype (CIMP). Microsatellites, also known as Short Tandem Repeats (STRs) are small (1-6 base pairs) repeating stretches of DNA scattered throughout the entire genome and account for approximately 3 % of the human genome...
2018: EXCLI journal
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