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Cell Death Discovery

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https://www.readbyqxmd.com/read/28326191/global-histone-modification-fingerprinting-in-human-cells-using-epigenetic-reverse-phase-protein-array
#1
Marina Partolina, Hazel C Thoms, Kenneth G MacLeod, Giovanny Rodriguez-Blanco, Matthew N Clarke, Anuroop V Venkatasubramani, Rima Beesoo, Vladimir Larionov, Vidushi S Neergheen-Bhujun, Bryan Serrels, Hiroshi Kimura, Neil O Carragher, Alexander Kagansky
The balance between acetylation and deacetylation of histone proteins plays a critical role in the regulation of genomic functions. Aberrations in global levels of histone modifications are linked to carcinogenesis and are currently the focus of intense scrutiny and translational research investments to develop new therapies, which can modify complex disease pathophysiology through epigenetic control. However, despite significant progress in our understanding of the molecular mechanisms of epigenetic machinery in various genomic contexts and cell types, the links between epigenetic modifications and cellular phenotypes are far from being clear...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28280602/impact-of-caspase-1-11-3-7-or-il-1%C3%AE-il-18-deficiency-on-rabies-virus-induced-macrophage-cell-death-and-onset-of-disease
#2
E Kip, F Nazé, V Suin, T Vanden Berghe, A Francart, S Lamoral, P Vandenabeele, R Beyaert, S Van Gucht, M Kalai
Rabies virus is a highly neurovirulent RNA virus, which causes about 59000 deaths in humans each year. Previously, we described macrophage cytotoxicity upon infection with rabies virus. Here we examined the type of cell death and the role of specific caspases in cell death and disease development upon infection with two laboratory strains of rabies virus: Challenge Virus Standard strain-11 (CVS-11) is highly neurotropic and lethal for mice, while the attenuated Evelyn-Rotnycki-Abelseth (ERA) strain has a broader cell tropism, is non-lethal and has been used as an oral vaccine for animals...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28280601/minimal-residual-disease-in-melanoma-circulating-melanoma-cells-and-predictive-role-of-mcam-muc18-melcam-cd146
#3
REVIEW
Maria Cristina Rapanotti, Elena Campione, Giulia Spallone, Augusto Orlandi, Sergio Bernardini, Luca Bianchi
Circulating tumour cells (CTCs), identified in numerous cancers including melanoma, are unquestionably considered valuable and useful as diagnostic and prognostic markers. They can be detected at all melanoma stages and may persist long after treatment. A crucial step in metastatic processes is the intravascular invasion of neoplastic cells as circulating melanoma cells (CMCs). Only a small percentage of these released cells are efficient and capable of colonizing with a strong metastatic potential. CMCs' ability to survive in circulation express a variety of genes with continuous changes of signal pathways and proteins to escape immune surveillance...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28250973/mpp-induces-necrostatin-1-and-ferrostatin-1-sensitive-necrotic-death-of-neuronal-sh-sy5y-cells
#4
Keisuke Ito, Yutaka Eguchi, Yusuke Imagawa, Shuji Akai, Hideki Mochizuki, Yoshihide Tsujimoto
Regulation of cell death is potentially a powerful treatment modality for intractable diseases such as neurodegenerative diseases. Although there have been many reports about the possible involvement of various types of cell death in neurodegenerative diseases, it is still unclear exactly how neurons die in patients with these diseases, thus treatment strategies based on cell death regulation have not been established yet. To obtain some insight into the mechanisms of cell death involved in neurodegenerative diseases, we studied the effect of 1-methyl-4-phenylpyridinium (MPP+) on the human neuroblastoma cell line SH-SY5Y (a widely used model of Parkinson's disease)...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28250972/antitumor-effects-of-naturally-occurring-cardiac-glycosides-convallatoxin-and-peruvoside-on-human-er-and-triple-negative-breast-cancers
#5
Vivek Kaushik, Neelam Azad, Juan Sebastian Yakisich, Anand Krishnan V Iyer
Breast cancer is second most prevalent cancer in women, and the second only to lung cancer in cancer-related deaths. It is a heterogeneous disease and has several subtypes based on the presence or absence of hormone receptors and/or human epidermal growth factor receptor 2 (HER2). Hormone receptor-positive and HER2-enriched cancers can be targeted using hormone and HER2-targeting therapies such as trastuzumab or lapatinib. However, triple-negative breast cancers (TNBCs) do not express any of the receptors and therefore are resistant to most targeted therapies, and cytotoxic chemotherapies are the only viable option available for the treatment of TNBCs...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28250971/atf3-reduces-migration-capacity-by-regulation-of-matrix-metalloproteinases-via-nf%C3%AE%C2%BAb-and-stat3-inhibition-in-glioblastoma
#6
Jessica Guenzle, Louisa J Wolf, Nicklas W C Garrelfs, Jonathan M Goeldner, Nadja Osterberg, Cora R Schindler, Joseph E Saavedra, Astrid Weyerbrock
Glioblastoma is associated with poor survival and a high recurrence rate in patients due to inevitable uncontrolled infiltrative tumor growth. The elucidation of the molecular mechanisms may offer opportunities to prevent relapses. In this study we investigated the role of the activating transcription factor 3 (ATF3) in migration of GBM cells in vitro. RNA microarray revealed that gene expression of ATF3 is induced by a variety of chemotherapeutics and experimental agents such as the nitric oxide donor JS-K (O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate)...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28250970/air-liquid-interface-enhances-oxidative-phosphorylation-in-intestinal-epithelial-cell-line-ipec-j2
#7
Sonja Klasvogt, Werner Zuschratter, Anke Schmidt, Andrea Kröber, Sandra Vorwerk, Romina Wolter, Berend Isermann, Klaus Wimmers, Hermann-Josef Rothkötter, Constanze Nossol
The intestinal porcine epithelial cell line IPEC-J2, cultured under the air-liquid interface (ALI) conditions, develops remarkable morphological characteristics close to intestinal epithelial cells in vivo. Improved oxygen availability has been hypothesised to be the leading cause of this morphological differentiation. We assessed oxygen availability in ALI cultures and examined the influence of this cell culture method on glycolysis and oxidative phosphorylation in IPEC-J2 using the submerged membrane culture (SMC) and ALI cultures...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28250969/mesenchymal-stem-cells-in-alleviating-sepsis-induced-mice-cardiac-dysfunction-via-inhibition-of-mtorc1-p70s6k-signal-pathway
#8
Wei Huang, Wensi Fan, Yabin Wang, Dong Han, Xiujuan Li, Shuang Li, Congye Li, Bin Xu, Yuesheng Huang, Xiaobin Fu, Feng Cao
Sepsis-induced cardiac dysfunction remains a major cause of morbidity and mortality in patients suffered from severe trauma. Mesenchymal stem cells (MSCs) -based treatment has been verified as a promising approach to mitigate the sepsis-induced cardiac dysfunction, but the mechanism is still ambiguous. Thus, our study was designed to explore the potential role of MSCs in sepsis-induced cardiac dysfunction. In vivo bioluminescence imaging revealed 80% acute donor cell death of bone marrow-derived MSCs (BM-MSCs) within 3 days after transplantation...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28243469/nos1-s-nitrosylates-pten-and-inhibits-autophagy-in-nasopharyngeal-carcinoma-cells
#9
Lingqun Zhu, Linlin Li, Qianbing Zhang, Xiao Yang, Zhiwei Zou, Bingtao Hao, Francesco M Marincola, Zhengjun Liu, Zhuo Zhong, Meng Wang, Xiaoxuan Li, Qianli Wang, Keyi Li, Wenwen Gao, Kaitai Yao, Qiuzhen Liu
Autophagy is a cellular survival mechanism that involves the catabolic degradation of damaged proteins and organelles during periods of metabolic stress, and when overly stimulated, commonly contributes to cell death. Nitric oxide (NO), a potent cellular messenger, participates in a complex mechanism which assists in controlling autophagy. However, the mechanism by which endogenous NO formed by distinct isoforms of nitric oxide synthase (NOS) helps to regulate autophagy in cancer cells remains unclear. Here we report that NOS1 reduces excessive levels of autophagy and promotes the survival of nasopharyngeal carcinoma cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28180000/haematopoietic-stem-cells-past-present-and-future
#10
REVIEW
Ashley P Ng, Warren S Alexander
The discovery and characterisation of haematopoietic stem cells has required decades of research. The identification of adult bone marrow as a source of haematopoietic cells capable of protecting an organism from otherwise lethal irradiation led to the intense search for their identity and characteristics. Using functional assays along with evolving techniques for isolation of haematopoietic cells, haematopoietic stem cell populations were able to be enriched and their characteristics analysed. The key haematopoietic stem cell characteristics of pluripotentiality and the ability for self-renewal have emerged as characteristics of several haematopoietic stem cell populations, including those that have recently challenged the conventional concepts of the haematopoietic hierarchy...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28179999/cancer-stem-like-cells-can-be-induced-through-dedifferentiation-under-hypoxic-conditions-in-glioma-hepatoma-and-lung-cancer
#11
Pan Wang, Wen-Wu Wan, Shuang-Long Xiong, Hua Feng, Nan Wu
Traditional studies have shown that transcription factors, including SOX-2, OCT-4, KLF-4, Nanog and Lin-28A, contribute to the dedifferentiation and reprogramming process in normal tissues. Hypoxia is a physiological phenomenon that exists in tumors and promotes the expression of SOX-2, OCT-4, KLF-4, Nanog and Lin-28A. Therefore, an interesting question is whether hypoxia as a stimulating factor promotes the process of dedifferentiation and induces the formation of cancer stem-like cells. Studies have shown that OCT-4 and Nanog overexpression induced the formation of cancer stem cell-like cells through dedifferentiation and enhanced malignancy in lung adenocarcinoma, and reprogramming SOX-2 in pancreatic cancer cells also promoted the dedifferentiation process...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28179998/phlpp-regulates-hexokinase-2-dependent-glucose-metabolism-in-colon-cancer-cells
#12
Xiaopeng Xiong, Yang-An Wen, Mihail I Mitov, Mary C Oaks, Shigeki Miyamoto, Tianyan Gao
Increased glucose metabolism is considered as one of the most important metabolic alterations adapted by cancer cells in order to generate energy as well as high levels of glycolytic intermediates to support rapid proliferation. PH domain leucine-rich repeat protein phosphatase (PHLPP) belongs to a novel family of Ser/Thr protein phosphatases that function as tumor suppressors in various types of human cancer. Here we determined the role of PHLPP in regulating glucose metabolism in colon cancer cells. Knockdown of PHLPP increased the rate of glucose consumption and lactate production, whereas overexpression of PHLPP had the opposite effect...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28179997/the-plant-defensin-nad1-induces-tumor-cell-death-via-a-non-apoptotic-membranolytic-process
#13
Amy A Baxter, Ivan Kh Poon, Mark D Hulett
Cationic anti-microbial peptides (CAPs) have an important role in host innate defense against pathogens such as bacteria and fungi. Many CAPs including defensins also exhibit selective cytotoxic activity towards mammalian cells via both apoptotic and non-apoptotic processes, and are being investigated as potential anticancer agents. The anti-fungal plant defensin from ornamental tobacco, Nicotiana alata Defensin 1 (NaD1), was recently shown to induce necrotic-like cell death in a number of tumor cell types within 30 min of treatment, at a concentration of 10 μM...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28179996/a-quantitative-real-time-approach-for-discriminating-apoptosis-and-necrosis
#14
Asha Lekshmi, Shankara Narayanan Varadarajan, Santhik Subhasingh Lupitha, Deepa Indira, Krupa Ann Mathew, Aneesh Chandrasekharan Nair, Mydhily Nair, Tilak Prasad, Hari Sekar, Anurup Kochucherukkan Gopalakrishnan, Abitha Murali, Thankayyan Retnabai Santhoshkumar
Apoptosis and necrosis are the two major forms of cell death mechanisms. Both forms of cell death are involved in several physiological and pathological conditions and also in the elimination of cancer cells following successful chemotherapy. Large number of cellular and biochemical assays have evolved to determine apoptosis or necrosis for qualitative and quantitative purposes. A closer analysis of the assays and their performance reveal the difficulty in using any of these methods as a confirmatory approach, owing to the secondary induction of necrosis in apoptotic cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28179995/caspase-mediated-proteolysis-of-the-sorting-nexin-2-disrupts-retromer-assembly-and-potentiates-met-hepatocyte-growth-factor-receptor-signaling
#15
Catherine M Duclos, Audrey Champagne, Julie C Carrier, Caroline Saucier, Christine L Lavoie, Jean-Bernard Denault
The unfolding of apoptosis involves the cleavage of hundreds of proteins by the caspase family of cysteinyl peptidases. Among those substrates are proteins involved in intracellular vesicle trafficking with a net outcome of shutting down the crucial processes governing protein transport to organelles and to the plasma membrane. However, because of the intertwining of receptor trafficking and signaling, cleavage of specific proteins may lead to unintended consequences. Here we show that in apoptosis, sorting nexin 1 and 2 (SNX1 and SNX2), two proteins involved in endosomal sorting, are cleaved by initiator caspases and also by executioner caspase-6 in the case of SNX2...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28179994/matrine-induces-rip3-dependent-necroptosis-in-cholangiocarcinoma-cells
#16
Beibei Xu, Minying Xu, Yuan Tian, Qiang Yu, Yujie Zhao, Xiong Chen, Panying Mi, Hanwei Cao, Bing Zhang, Gang Song, Yan-Yan Zhan, Tianhui Hu
The development of acquired resistance to pro-apoptotic antitumor agents is a major impediment to the cure of cholangiocarcinoma (CCA). Antitumor drugs inducing non-apoptotic cell death are considered as a new approach to overcome such drug resistance. Here, we reported for the first time that matrine-induced necroptosis in CCA cell lines, differing from its classical role to induce apoptosis in many other kinds of cancer cells. CCA cells under matrine treatment exhibited typical necrosis-like but not apoptotic morphologic change...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28179993/close-encounter-of-the-covalent-kind-inhibiting-mcl1-s-proapoptotic-activity-with-covalent-inhibitors
#17
EDITORIAL
Guillaune Lessene
No abstract text is available yet for this article.
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28179992/martin-leverkus-1965-2016
#18
EDITORIAL
Henning Walczak, Martin R Sprick
No abstract text is available yet for this article.
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28179991/a-homolog-of-cyclophilin-d-is-expressed-in-trypanosoma-cruzi-and-is-involved-in-the-oxidative-stress-damage-response
#19
Patricia L Bustos, Bibiana J Volta, Alina E Perrone, Natalia Milduberger, Jacqueline Bua
Mitochondria have an important role in energy production, homeostasis and cell death. The opening of the mitochondrial permeability transition pore (mPTP) is considered one of the key events in apoptosis and necrosis, modulated by cyclophilin D (CyPD), a crucial component of this protein complex. In Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, we have previously described that mitochondrial permeability transition occurs after oxidative stress induction in a cyclosporin A-dependent manner, a well-known cyclophilin inhibitor...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28179990/brian-benedetti-williams-1956-2016
#20
EDITORIAL
M Benedetti-Johnson
No abstract text is available yet for this article.
2017: Cell Death Discovery
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