Read by QxMD icon Read

ACS Central Science

Salvador Barraza-Lopez, Thaneshwor P Kaloni
The experimental exfoliation of layered group-IV monochalcogenides-semiconductors isostructural to black phosphorus-using processes similar to those followed in the production of graphene or phosphorene has turned out unsuccessful thus far, as if the chemical degradation observed in black phosphorus was aggravated in these monochalcogenides. Here, we document a facile dissociation of water by these materials within 10 ns from room-temperature Car-Parrinello molecular dynamics calculations under standard temperature and pressure conditions...
October 24, 2018: ACS Central Science
Chi Chung Lee, Yilin Hu, Markus W Ribbe
Isolated nitrogenase cofactors can reduce CO, CN- , and CO2 to short-chain hydrocarbons in reactions driven by a strong reductant. Here, we use activity analyses and isotope labeling experiments to show that formaldehyde and acetaldehydes can be reduced as-is or reductively condensed into alkanes and alkenes by the isolated cofactor of Mo-nitrogenase in the presence of EuII -diethylenetriamine pentaacetate (DTPA). Further, we demonstrate that aldehydes can be condensed with CO by the isolated cofactor under the same reaction conditions, pointing to aldehyde-derived species as possible intermediates of nitrogenase-catalyzed CO reduction...
October 24, 2018: ACS Central Science
Sukhmanjot Kaur, Amal Narayanan, Siddhesh Dalvi, Qianhui Liu, Abraham Joy, Ali Dhinojwala
Marine organisms such as mussels have mastered the challenges in underwater adhesion by incorporating post-translationally modified amino acids like l-3,4-dihydroxyphenylalanine (DOPA) in adhesive proteins. Here we designed a catechol containing elastomer adhesive to identify the role of catechol in interfacial adhesion in both dry and wet conditions. To decouple the adhesive contribution of catechol to the overall adhesion, the elastomer was designed to be cross-linked through [2 + 2] photo-cycloaddition of coumarin...
October 24, 2018: ACS Central Science
Hao Lv, Aaron Lopes, Dongdong Xu, Ben Liu
Controlling the nanostructures and chemical compositions of the electrochemical nanocatalysts has been recognized as two prominent means to kinetically promote the electrocatalytic performance. Herein, we report a general "dual"-template synthesis methodology for the formation of multimetallic hollow mesoporous nanospheres (HMSs) with an adjustable interior hollow cavity and cylindrically opened mesoporous shell as a highly efficient electrocatalyst for ethanol oxidation reaction. Three-dimensional trimetallic PdAgCu HMSs were synthesized via in situ coreduction of Pd, Ag, and Cu precursors on "dual"-template structural directing surfactant of dioctadecyldimethylammonium chloride in optimal synthesis conditions...
October 24, 2018: ACS Central Science
Yuhui Liao, Zhijin Fan, Huaping Deng, Yang Yang, Jingyan Lin, Zhaoyan Zhao, Qingqin Tan, Bin Li, Xi Huang
Zika virus (ZIKV) is a mosquito-borne flavivirus that leads to devastating consequences for fetal development. However, accurate diagnosis of ZIKV is made difficult by the fact that most infected patients are asymptomatic or present with symptoms similar to those of other febrile illnesses. Thus, the development of a simple, accurate, highly sensitive, and reliable method for the biomedical analysis and diagnosis of ZIKV is needed. Herein, a novel ZIKV liquid biopsy system was constructed via a dendritic Ru(bpy)3 2+ -polymer-amplified electro-chemiluminescence (ECL) strategy...
October 24, 2018: ACS Central Science
Gabriella M Fernandes-Cunha, Colin J McKinlay, Jessica R Vargas, Henning J Jessen, Robert M Waymouth, Paul A Wender
Inorganic polyphosphate (polyP) is an often-overlooked biopolymer of phosphate residues present in living cells. PolyP is associated with many essential biological roles. Despite interest in polyP's function, most studies have been limited to extracellular or isolated protein experiments, as polyanionic polyP does not traverse the nonpolar membrane of cells. To address this problem, we developed a robust, readily employed method for polyP delivery using guanidinium-rich oligocarbonate transporters that electrostatically complex polyPs of multiple lengths, forming discrete nanoparticles that are resistant to phosphatase degradation and that readily enter multiple cell types...
October 24, 2018: ACS Central Science
Rebecca F Wissner, Angela Steinauer, Susan L Knox, Alexander D Thompson, Alanna Schepartz
New methods for delivering proteins into the cytosol of mammalian cells are being reported at a rapid pace. Differentiating between these methods in a quantitative manner is difficult, however, as most assays for evaluating cytosolic protein delivery are qualitative and indirect and thus often misleading. Here we make use of fluorescence correlation spectroscopy (FCS) to determine with precision and accuracy the relative efficiencies with which seven different previously reported "cell-penetrating peptides" (CPPs) transport a model protein cargo-the self-labeling enzyme SNAP-tag-beyond endosomal membranes and into the cytosol...
October 24, 2018: ACS Central Science
Rishikesh U Kulkarni, Matthieu Vandenberghe, Martin Thunemann, Feroz James, Ole A Andreassen, Srdjan Djurovic, Anna Devor, Evan W Miller
Optical methods that rely on fluorescence for mapping changes in neuronal membrane potential in the brains of awake animals provide a powerful way to interrogate the activity of neurons that underlie neural computations ranging from sensation and perception to learning and memory. To achieve this goal, fluorescent indicators should be bright, highly sensitive to small changes in membrane potential, nontoxic, and excitable with infrared light. We report a new class of fluorescent, voltage-sensitive dyes: sulfonated rhodamine voltage reporters (sRhoVR), synthetic fluorophores with high voltage sensitivity, excellent two-photon performance, and compatibility in intact mouse brains...
October 24, 2018: ACS Central Science
Katherine E Zink, Matthew Dean, Joanna E Burdette, Laura M Sanchez
High grade serous ovarian cancer (HGSOC) is the fifth leading cause of cancer deaths among women. New evidence suggests that HGSOC arises in the fallopian tube and then colonizes the ovary before spreading into the peritoneal space. Therefore, due to the proximity of this metastasis, an experimental design was optimized using imaging mass spectrometry to capture the spatial composition of small molecules uniquely expressed when fallopian-tube-derived tumor cells were grown in the microenvironment of the ovary as a model of primary metastasis...
October 24, 2018: ACS Central Science
Xiaoyu Zhang, Min Lu, Yu Zhang, Hua Wu, Xinyu Shen, Wei Zhang, Weitao Zheng, Vicki L Colvin, William W Yu
Cesium lead halide perovskite nanocrystals (NCs) have unique optical properties such as high color purity and high photoluminescence (PL) efficiency. However, the external quantum efficiency (EQE) of the corresponding light-emitting diodes (LEDs) is low, primarily as a result of the NC surface defects. Here, we report a method to reduce the surface defects by capping CsPbI3 NCs with PbS. This passivation significantly enhanced the PL efficiency, reduced the Stokes shift, narrowed the PL bandwidth, and increased the stability of CsPbI3 NCs...
October 24, 2018: ACS Central Science
Hongming Ding, Jiang Li, Nan Chen, Xingjie Hu, Xiafeng Yang, Linjie Guo, Qian Li, Xiaolei Zuo, Lihua Wang, Yuqiang Ma, Chunhai Fan
Cell entry of anionic nano-objects has been observed in various types of viruses and self-assembled DNA nanostructures. Nevertheless, the physical mechanism underlying the internalization of these anionic particles across the negatively charged cell membrane remains poorly understood. Here, we report the use of virus-mimicking designer DNA nanostructures with near-atomic resolution to program "like-charge attraction" at the interface of cytoplasmic membranes. Single-particle tracking shows that cellular internalization of tetrahedral DNA nanostructures (TDNs) depends primarily on the lipid-raft-mediated pathway, where caveolin plays a key role in providing the short-range attraction at the membrane interface...
October 24, 2018: ACS Central Science
Marten Prieß, Hendrik Göddeke, Gerrit Groenhof, Lars V Schäfer
Hydrolysis of nucleoside triphosphate (NTP) plays a key role for the function of many biomolecular systems. However, the chemistry of the catalytic reaction in terms of an atomic-level understanding of the structural, dynamic, and free energy changes associated with it often remains unknown. Here, we report the molecular mechanism of adenosine triphosphate (ATP) hydrolysis in the ATP-binding cassette (ABC) transporter BtuCD-F. Free energy profiles obtained from hybrid quantum mechanical/molecular mechanical (QM/MM) molecular dynamics (MD) simulations show that the hydrolysis reaction proceeds in a stepwise manner...
October 24, 2018: ACS Central Science
Wanwan Shen, Qingwei Wang, Yang Shen, Xiao Gao, Lei Li, Yang Yan, Hui Wang, Yiyun Cheng
Cytosolic delivery is the major challenge that limits the clinical translation of siRNA-based therapeutics. Although thousands of polymers have been developed for siRNA delivery, the efficiency-toxicity correlation is unsatisfactory. Here, we report a facile strategy to fabricate core-shell-structured nanoparticles with robust siRNA delivery efficiency. The nanoparticle is prepared by entropy-driven complexation of siRNA with a green tea catechin to yield a negatively charged core, followed by coating low-molecular-weight polymers to form the shell...
October 24, 2018: ACS Central Science
Jenny Marie Andersson, Kevin Roger, Marcus Larsson, Emma Sparr
The lipid-protein mixture that covers the lung alveoli, lung surfactant, ensures mechanical robustness and controls gas transport during breathing. Lung surfactant is located at an interface between water-rich tissue and humid, but not fully saturated, air. The resulting humidity difference places the lung surfactant film out of thermodynamic equilibrium, which triggers the buildup of a water gradient. Here, we present a millifluidic method to assemble multilamellar interfacial films from vesicular dispersions of a clinical lung surfactant extract used in replacement therapy...
October 24, 2018: ACS Central Science
Jeong-Eun Park, Yoonjae Jung, Minho Kim, Jwa-Min Nam
Plasmonics, the study of the interactions between photons and collective oscillations of electrons, has seen tremendous advances during the past decade. Controllable nanometer- and sub-nanometer-scale engineering in plasmonic resonance and electromagnetic field localization at the subwavelength scale have propelled diverse studies in optics, materials science, chemistry, biotechnology, energy science, and various applications in spectroscopy. However, for translation of these accomplishments from research into practice, major hurdles including low reproducibility and poor controllability in target structures must be overcome, particularly for reliable quantification of plasmonic signals and functionalities...
October 24, 2018: ACS Central Science
Maria João Ramos, Pedro Alexandrino Fernandes
No abstract text is available yet for this article.
October 24, 2018: ACS Central Science
Pengfei Wang, Yonggang Ke
No abstract text is available yet for this article.
October 24, 2018: ACS Central Science
Carmen Drahl
No abstract text is available yet for this article.
October 24, 2018: ACS Central Science
Neil Savage
No abstract text is available yet for this article.
October 24, 2018: ACS Central Science
Carolyn R Bertozzi
No abstract text is available yet for this article.
October 24, 2018: ACS Central Science
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"