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Allergo Journal International

Caspar Ohnmacht
No abstract text is available yet for this article.
2016: Allergo Journal International
Friedrich Altmann
A relevant proportion of allergy diagnosis is accomplished by in vitro determination of specific immunglobulin E (sIgE) to extracts from suspected allergens. Such extracts inevitably contain glycoproteins, which may react with patients' IgE. In the case of plant and insect allergens, the relevant epitope structure is an α-1,3-fucose on the Asn-linked sugar residue of so-called N-glycans. Due to their wide distribution, N-glycans carrying this epitope are known as "cross-reactive carbohydrate determinant(s)" (CCD[s])...
2016: Allergo Journal International
Danijela Apostolovic, Thi Anh Thu Tran, Maria Starkhammar, Sara Sánchez-Vidaurre, Carl Hamsten, Marianne Van Hage
In the last decade, a novel type of food allergy presenting with severe allergic reactions several hours after consumption of red meat has been recognized. The allergic responses are due to IgE antibodies directed against the carbohydrate epitope galactose-α-1,3-galactose (α-Gal) found in mammalian meat. This review presents the red meat allergy syndrome in Sweden, discusses the features of the immune response to carbohydrates, and highlights the presence of heat stable α-Gal-containing proteins in meat...
2016: Allergo Journal International
Wolfgang Hemmer, Christoph Klug, Ines Swoboda
Allergy to poultry meat is rare and affects both children and adults. The prevalence of poultry meat allergy is unknown, but presumably is similar to that of red meat allergy. There is no close relationship between allergy to poultry meat and allergy to red meat. Poultry meat allergy may present as primary (genuine) food allergy or as secondary food allergy resulting from cross-reactivity. Secondary poultry meat allergy may arise in the context of bird-egg-syndrome, which is due to sensitization to serum albumins present in many tissues including muscle tissue and egg yolk (Gal d 5)...
2016: Allergo Journal International
Thomas Werfel, Annice Heratizadeh, Werner Aberer, Frank Ahrens, Matthias Augustin, Tilo Biedermann, Thomas Diepgen, Regina Fölster-Holst, Uwe Gieler, Julia Kahle, Alexander Kapp, Alexander Nast, Katja Nemat, Hagen Ott, Bernhard Przybilla, Martin Roecken, Martin Schlaeger, Peter Schmid-Grendelmeier, Jochen Schmitt, Thomas Schwennesen, Doris Staab, Margitta Worm
Atopic dermatitis (AD) represents a pruritic, non-contagious, chronic or chronically relapsing, inflammatory skin disease. The course of the disease may be complicated by bacterial or viral superinfections. The first manifestation of the disease and further flare-ups are due to genetic predisposition and also to a variety of further trigger factors. The therapy regimen should be adapted to disease symptoms that are actually present and consider individual features of the disease as reported by the patients or their parents...
2016: Allergo Journal International
Jörg Fischer, Amir S Yazdi, Tilo Biedermann
The term α-Gal syndrome describes a novel IgE-mediated immediate-type allergy to the disaccharide galactose-α-1,3-galactose (α-Gal). Its classification as a syndrome is proposed on the basis of its clinical relevance in three different fields of allergy: food, drugs, and tick bites. The main focus of the present article is on α-Gal as an eliciting allergen in food allergy. It was recently shown that immediate-type allergies to pork kidney and other mammalian innards belong to the spectrum of α-Gal syndrome...
2016: Allergo Journal International
Randolf Brehler, Ludger Klimek, Christian Vogelberg, Thomas Werfel, Oliver Pfaar, Eckard Hamelmann
The recently published S2k-guideline on (allergen-) specific immunotherapy (AIT) provides an excellent overview of the evidence on allergen preparations available for AIT in Germany based on the published efficacy studies. Publications based on the guideline are currently being used by the German associations of statutory health insurance physicians and German health insurance funds to open a discussion on the reimbursement status of allergen preparations. In our view, calling the reimbursement status of perscribable and tradable AIT preparations into question on the basis of an assessment of the current body of evidence in the guideline is to be rigidly opposed...
2016: Allergo Journal International
Marek Lommatzsch, Paul Stoll
Novel treatment strategies are currently emerging for patients with inadequately controlled asthma despite good adherence and trigger avoidance. These strategies serve primarily to reduce or completely avoid long-term oral corticosteroid therapy. A number of these options have already been implemented in practice or will soon be authorized for the treatment of asthma, while others still need to prove their clinical practicability, safety and efficacy. The present article provides an overview of the broad spectrum of novel inhaled, oral, systemic, and invasive treatment strategies for asthma...
2016: Allergo Journal International
Karl-Christian Bergmann, Joachim Heinrich, Hildegard Niemann
The lifetime prevalence of allergic diseases in adults in Germany [self-reported doctor diagnosed allergic diseases, Study on Adult Health in Germany (Studie zur Gesundheit Erwachsener in Deutschland, DEGS1, 2008-2011) of the Robert Koch Institute] is 8.6 % for asthma, 14.8 % for hay fever, 3.5 % for atopic dermatitis, 8.1 % for contact dermatitis, 4.7 % for food allergies, and 2.8 % for insect venom allergies. Almost 20 % of German adults are currently affected by at least one allergy. In tests on 50 common single allergens and two mixtures comprising either inhalant allergens or grass pollen allergens, 48...
2016: Allergo Journal International
Jeroen Buters, Beate Alberternst, Stefan Nawrath, Maria Wimmer, Claudia Traidl-Hoffmann, Uwe Starfinger, Heidrun Behrendt, Carsten Schmidt-Weber, Karl-Christian Bergmann
Ambrosia artemisiifolia (ragweed) is a neophyte in Europe and Germany, which originated from the United States of America. In the USA the rate of sensitization against ragweed equals that of grass pollen, and without containment the rate of allergic sensitizations against ragweed pollen will clearly increase. Currently, the most frequent sensitizations in Germany are against grass pollen, followed by sensitizations against house dust mite and birch pollen. Ragweed pollen evokes symptoms at about 10 pollen/m3, grass pollen at about 15 pollen/m3...
2015: Allergo Journal International
Thilo Jakob, Peter Forstenlechner, Paolo Matricardi, Jörg Kleine-Tebbe
The availability of single allergens and their use in microarray technology enables the simultaneous determination of specific IgE (sIgE) to a multitude of different allergens (> 100) in a multiplex procedure requiring only minute amounts of serum. This allows extensive individual sensitization profiles to be determined from a single analysis. Combined with a patient's medical history, these profiles simplify identification of cross-reactivity; permit a more accurate estimation of the risk of severe reactions; and enable the indication for specific immunotherapy to be more precisely established, particularly in cases of polysensitization...
2015: Allergo Journal International
Andreas Distler, Debbie Pappelendam
BACKGROUND: The Paul-Ehrlich-Institut (PEI) published an analysis of reports of adverse drug reactions (ADRs) in 2001 with test and therapy allergens from the period from 1991 to 2000. Possible risk factors were evaluated for the ADR reports classified as "serious". During the analyzed period, modified semi-depot preparations (allergoids) induced between 0.01 % and 0.0005 % serious systemic reactions, i. e. one serious ADR occurred in 10,000 to 200,000 injections. No information was provided regarding the respective incidences in relation to the individual companies or preparations...
2015: Allergo Journal International
Margitta Worm, Imke Reese, Barbara Ballmer-Weber, Kirsten Beyer, Stephan C Bischoff, Martin Classen, Peter J Fischer, Thomas Fuchs, Isidor Huttegger, Uta Jappe, Ludger Klimek, Berthold Koletzko, Lars Lange, Ute Lepp, Vera Mahler, Bodo Niggemann, Ute Rabe, Martin Raithel, Joachim Saloga, Christiane Schäfer, Sabine Schnadt, Jens Schreiber, Zsolt Szépfalusi, Regina Treudler, Martin Wagenmann, Bernhard Watzl, Thomas Werfel, Torsten Zuberbier, Jörg Kleine-Tebbe
No abstract text is available yet for this article.
2015: Allergo Journal International
Johannes Huss-Marp, Monika Raulf, Thilo Jakob
Essentially, allergen components offer three possibilities to improve in vitro IgE diagnostics: Allergen components can be used individually for IgE determination.Allergen components can be combined as a mix in one test.Individual allergen components can be specifically added to the extract. Option (a) is currently being used most extensively in practice, while (b) represents more of a theoretical possibility. The specific addition ("spiking") of allergen components to an allergy extract (c) has been performed in the past for the ImmunoCAP® tests for latex (09/2001), hazelnut (05/2006) and wasp venom (06/2012)...
2015: Allergo Journal International
Jörg Kleine-Tebbe, Thilo Jakob
: Allergen molecules (synonyms: single allergens, allergen components) open up new horizons for the targeted allergen-specific diagnostics of immunoglobulin E (IgE) in singleplex determination. The following rationales support the targeted use of allergen molecules and, more importantly, improve test properties: (1) increased test sensitivity ("analytical sensitivity"), particularly when important allergens are under-represented or lacking in the extract; (2) improved test selectivity (analytical specificity), particularly when the selected IgE repertoire against an allergen yields additional information on: (a) potential risk, (b) possible cross-reactivity, or (c) primary (species-specific) sensitization...
2015: Allergo Journal International
Imke Reese, Thomas Holzhauser, Sabine Schnadt, Sabine Dölle, Jörg Kleine-Tebbe, Martin Raithel, Margitta Worm, Torsten Zuberbier, Stefan Vieths
Individuals suffering from IgE-mediated food allergies are obliged to systematically eliminate the culprit allergen from their diet. To support allergic consumers in avoiding food allergens to make informed and safe purchasing choices, the European Union (EU) Food Information Regulation (FIR) imposes a requirement to label the 13 most common allergenic foods (food groups) as ingredients in pre-packed and non-pre-packed foods. The as yet unregulated labelling of unintended presence of allergens has lead to a widespread use of precautionary allergen labelling (PAL) - despite established allergen management in many companies...
2015: Allergo Journal International
Sachiko Ono, Kenji Kabashima
The skin is equipped with serial barriers that provide rapid and efficient protection against external intruders. Beneath the epidermal physical barriers of the stratum corneum and the tight junctions, the integrated immune systems in both the epidermis and the dermis act in a coordinated manner to protect the host. This "immunological" barrier is composed of various cells, including skin-resident cells, such as keratinocytes, dendritic cells, tissue-resident macrophages, resident memory T cells, mast cells, and innate lymphoid cells...
2015: Allergo Journal International
Johannes Huss-Marp, Jan Gutermuth, Ina Schäffner, Ulf Darsow, Florian Pfab, Knut Brockow, Johannes Ring, Heidrun Behrendt, Thilo Jakob, Christoph Ahlgrim
BACKGROUND: ImmunoCAP ISAC 112, is a commercially available molecular allergy IgE multiplex test. Data on the comparison of this rather novel test with extract-based as well as molecular ImmunoCAP singleplex IgE tests is missing. OBJECTIVE: To perform a comparison between the ISAC multiplex IgE assay and the ImmunoCAP singleplex test results. METHODS: Serum samples of 101 adults with grass pollen allergy were analysed for sIgE to 112 allergenic molecules represented on the ISAC test as well as to common atopy-related extract-based allergy tests with the ImmunoCAP System (house dust mite [d1], cat [e1], dog [e5], cow's milk [f2], hen's egg [f1], hazelnut [f17], celery [f85], Alternaria alternate [m6], as well as pollen from birch [t3], hazel [t4], mugwort [w6], and ragweed [w1])...
2015: Allergo Journal International
Knut Brockow, Bernhard Przybilla, Werner Aberer, Andreas J Bircher, Randolf Brehler, Heinrich Dickel, Thomas Fuchs, Thilo Jakob, Lars Lange, Wolfgang Pfützner, Maja Mockenhaupt, Hagen Ott, Oliver Pfaar, Johannes Ring, Bernhardt Sachs, Helmut Sitter, Axel Trautmann, Regina Treudler, Bettina Wedi, Margitta Worm, Gerda Wurpts, Torsten Zuberbier, Hans F Merk
Drug hypersensitivity reactions are unpredictable adverse drug reactions. They manifest either within 1-6 h following drug intake (immediate reactions) with mild to life-threatening symptoms of anaphylaxis, or several hours to days later (delayed reactions), primarily as exanthematous eruptions. It is not always possible to detect involvement of the immune system (allergy). Waiving diagnostic tests can result in severe reactions on renewed exposure on the one hand, and to unjustified treatment restrictions on the other...
2015: Allergo Journal International
Ludger Klimek, Thomas Werfel, Christian Vogelberg, Kirsten Jung
BACKGROUND: Beside the skin prick test, the intracutaneous test represents the most important skin test method for detecting type-1 allergies. With the incorporation of European directives into national law, test allergens used for allergy diagnosis are deemed medicinal products within the meaning of the German Medicinal Products Act (Arzneimittelgesetz) and therefore require marketing authorisation for distribution in Germany. The high costs of acquiring and maintaining these authorisations have lead to no new finished intracutaneous test products being authorized in Germany for more than 20 years...
2015: Allergo Journal International
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