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EJNMMI Physics

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https://www.readbyqxmd.com/read/28084612/an-experimental-phantom-study-of-the-effect-of-gadolinium-based-mr-contrast-agents-on-pet-attenuation-coefficients-and-pet-quantification-in-pet-mr-imaging-application-to-cardiac-studies
#1
Jim O' Doherty, Paul Schleyer
BACKGROUND: Simultaneous cardiac perfusion studies are an increasing trend in PET-MR imaging. During dynamic PET imaging, the introduction of gadolinium-based MR contrast agents (GBCA) at high concentrations during a dual injection of GBCA and PET radiotracer may cause increased attenuation effects of the PET signal, and thus errors in quantification of PET images. We thus aimed to calculate the change in linear attenuation coefficient (LAC) of a mixture of PET radiotracer and increasing concentrations of GBCA in solution and furthermore, to investigate if this change in LAC produced a measurable effect on the image-based PET activity concentration when attenuation corrected by three different AC strategies...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28070731/evaluation-of-two-intraoperative-gamma-detectors-for-assessment-of-177-lu-activity-concentration-in-vivo
#2
Viktor Sandblom, Ingun Ståhl, Roger Olofsson Bagge, Eva Forssell-Aronsson
BACKGROUND: Patients with somatostatin receptor-expressing neuroendocrine tumours can be treated with intravenously administered (177)Lu-octreotate. Few patients are cured with the present protocol due to the current dose limitation of normal organs at risk, such as the kidneys. By locally administering (177)Lu-octreotate to the liver for the purpose of treating liver metastases, a substantially reduced absorbed dose to organs at risk could be achieved. The development of such a technique requires the capability of measuring the (177)Lu activity concentration in tissues in vivo...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28063068/accuracy-of-177-lu-activity-quantification-in-spect-imaging-a-phantom-study
#3
Carlos F Uribe, Pedro L Esquinas, Jesse Tanguay, Marjorie Gonzalez, Emilie Gaudin, Jean-Mathieu Beauregard, Anna Celler
BACKGROUND: The aim of the study is to assess accuracy of activity quantification of (177)Lu studies performed according to recommendations provided by the committee on Medical Internal Radiation Dose (MIRD) pamphlets 23 and 26. The performances of two scatter correction and three segmentation methods were compared. Additionally, the accuracy of tomographic and planar methods for determination of the camera normalization factor (CNF) was evaluated. Eight phantoms containing inserts of different sizes and shapes placed in air, water, and radioactive background were scanned using a Siemens SymbiaT SPECT/CT camera...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28058674/quantitative-myocardial-blood-flow-imaging-with-integrated-time-of-flight-pet-mr
#4
Tanja Kero, Jonny Nordström, Hendrik J Harms, Jens Sörensen, Håkan Ahlström, Mark Lubberink
BACKGROUND: The use of integrated PET-MR offers new opportunities for comprehensive assessment of cardiac morphology and function. However, little is known on the quantitative accuracy of cardiac PET imaging with integrated time-of-flight PET-MR. The aim of the present work was to validate the GE Signa PET-MR scanner for quantitative cardiac PET perfusion imaging. Eleven patients (nine male; mean age 59 years; range 46-74 years) with known or suspected coronary artery disease underwent (15)O-water PET scans at rest and during adenosine-induced hyperaemia on a GE Discovery ST PET-CT and a GE Signa PET-MR scanner...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/27987183/a-gamma-distribution-convolution-model-of-99m-tc-mibi-thyroid-time-activity-curves
#5
Carl A Wesolowski, Surajith N Wanasundara, Michal J Wesolowski, Belkis Erbas, Paul S Babyn
BACKGROUND: The convolution approach to thyroid time-activity curve (TAC) data fitting with a gamma distribution convolution (GDC) TAC model following bolus intravenous injection is presented and applied to (99m)Tc-MIBI data. The GDC model is a convolution of two gamma distribution functions that simultaneously models the distribution and washout kinetics of the radiotracer. The GDC model was fitted to thyroid region of interest (ROI) TAC data from 1 min per frame (99m)Tc-MIBI image series for 90 min; GDC models were generated for three patients having left and right thyroid lobe and total thyroid ROIs, and were contrasted with washout-only models, i...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27957730/pharmacokinetic-modeling-of-a-novel-hypoxia-pet-tracer-18-f-hx4-in-patients-with-non-small-cell-lung-cancer
#6
E E Verwer, C M L Zegers, W van Elmpt, R Wierts, A D Windhorst, F M Mottaghy, P Lambin, R Boellaard
BACKGROUND: [(18)F]HX4 is a promising new PET tracer developed to identify hypoxic areas in tumor tissue. This study analyzes [(18)F]HX4 kinetics and assesses the performance of simplified methods for quantification of [(18)F]HX4 uptake. To this end, eight patients with non-small cell lung cancer received dynamic PET scans at three different time points (0, 120, and 240 min) after injection of 426 ± 72 MBq [(18)F]HX4, each lasting 30 min. Several compartment models were fitted to time activity curves (TAC) derived from various areas within tumor tissue using image-derived input functions...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27928774/a-3d-printed-anatomical-pancreas-and-kidney-phantom-for-optimizing-spect-ct-reconstruction-settings-in-beta-cell-imaging-using-111-in-exendin
#7
Wietske Woliner-van der Weg, Laura N Deden, Antoi P W Meeuwis, Maaike Koenrades, Laura H C Peeters, Henny Kuipers, Geert Jan Laanstra, Martin Gotthardt, Cornelis H Slump, Eric P Visser
BACKGROUND: Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with (111)In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27844449/estimation-of-activity-of-administered-18-f-fluorodeoxyglucose-by-measurement-of-the-dose-equivalent-rate-on-the-right-temporal-region-of-the-head
#8
Kenta Sakaguchi, Makoto Hosono, Tomomi Imamura, Naomi Takahara, Misa Hayashi, Yuko Yakushiji, Kazunari Ishii, Tatsuro Uto, Takamichi Murakami
BACKGROUND: Positron emission tomography (PET) with (18)F-fluorodeoxyglucose (FDG) is now a routine procedure for the management of cancer patients. Intravenous administration of FDG is sometimes halted due to troubles. In such cases, estimations of the FDG dosage injected prior to halting administration may be helpful. We have established a method of estimating the activity of FDG to patients on the basis of the dose equivalent rate on the surface of the right temporal region of the head...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27837548/left-ventricular-function-assessment-using-123-i-99m-tc-dual-isotope-acquisition-with-two-semi-conductor-cadmium-zinc-telluride-czt-cameras-a-gated-cardiac-phantom-study
#9
Tanguy Blaire, Alban Bailliez, Fayçal Ben Bouallegue, Dimitri Bellevre, Denis Agostini, Alain Manrique
BACKGROUND: The impact of increased energy resolution of cadmium-zinc-telluride (CZT) cameras on the assessment of left ventricular function under dual-isotope conditions ((99m)Tc and (123)I) remains unknown. The Amsterdam-gated dynamic cardiac phantom (AGATE, Vanderwilt techniques, Boxtel, The Netherlands) was successively filled with a solution of (123)I alone, (99m)Tc alone, and a mixture of (123)I and (99m)Tc. A total of 12 datasets was acquired with each commercially available CZT camera (DNM 530c, GE Healthcare and DSPECT, Biosensors International) using both energy windows ((99m)Tc or (123)I) with ejection fraction set to 33, 45, and 60 %...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27783373/evaluation-of-spatial-dependence-of-point-spread-function-based-pet-reconstruction-using-a-traceable-point-like-22-na-source
#10
Taisuke Murata, Kenta Miwa, Noriaki Miyaji, Kei Wagatsuma, Tomoyuki Hasegawa, Keiichi Oda, Takuro Umeda, Takashi Iimori, Yoshitada Masuda, Takashi Terauchi, Mitsuru Koizumi
BACKGROUND: The point spread function (PSF) of positron emission tomography (PET) depends on the position across the field of view (FOV). Reconstruction based on PSF improves spatial resolution and quantitative accuracy. The present study aimed to quantify the effects of PSF correction as a function of the position of a traceable point-like (22)Na source over the FOV on two PET scanners with a different detector design. METHODS: We used Discovery 600 and Discovery 710 (GE Healthcare) PET scanners and traceable point-like (22)Na sources (<1 MBq) with a spherical absorber design that assures uniform angular distribution of the emitted annihilation photons...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27770429/radiation-dosimetry-of-the-%C3%AE-4%C3%AE-2-nicotinic-receptor-ligand-18-f-flubatine-comparing-preclinical-pet-mri-and-pet-ct-to-first-in-human-pet-ct-results
#11
Mathias Kranz, Bernhard Sattler, Solveig Tiepolt, Stephan Wilke, Winnie Deuther-Conrad, Cornelius K Donat, Steffen Fischer, Marianne Patt, Andreas Schildan, Jörg Patt, René Smits, Alexander Hoepping, Jörg Steinbach, Osama Sabri, Peter Brust
BACKGROUND: Both enantiomers of [(18)F]flubatine are new radioligands for neuroimaging of α4β2 nicotinic acetylcholine receptors with positron emission tomography (PET) exhibiting promising pharmacokinetics which makes them attractive for different clinical questions. In a previous preclinical study, the main advantage of (+)-[(18)F]flubatine compared to (-)-[(18)F]flubatine was its higher binding affinity suggesting that (+)-[(18)F]flubatine might be able to detect also slight reductions of α4β2 nAChRs and could be more sensitive than (-)-[(18)F]flubatine in early stages of Alzheimer's disease...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27766592/measurement-of-cardiovascular-function-using-a-novel-view-sharing-pet-reconstruction-method-and-tracer-kinetic-analysis
#12
Paul R Territo, Amanda A Riley, Brian P McCarthy, Gary D Hutchins
Recent advancements in PET instrumentation have made the non-invasive assessment of cardiovascular function in small animals a reality. The majority of small animal PET systems use stationary detector gantries, thus affording high temporal resolution imaging of cardiac function. Systems designed to maximize spatial resolution and detection sensitivity employing rotating gantry designs are suboptimal when high temporal resolution imaging is needed. To overcome this limitation, the current work developed a novel view-sharing data analysis scheme suitable for dynamic cardiac PET imaging using (18)F-NaF as the tracer and tracer kinetic model analysis...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27709546/phantom-criteria-for-qualification-of-brain-fdg-and-amyloid-pet-across-different-cameras
#13
Yasuhiko Ikari, Go Akamatsu, Tomoyuki Nishio, Kenji Ishii, Kengo Ito, Takeshi Iwatsubo, Michio Senda
BACKGROUND: While fluorodeoxyglucose (FDG) and amyloid PET is valuable for patient management, research, and clinical trial of therapeutics on Alzheimer's disease, the specific details of the PET scanning method including the PET camera model type influence the image quality, which may further affect the interpretation of images and quantitative capabilities. To make multicenter PET data reliable and to establish PET scanning as a universal diagnostic technique and a verified biomarker, we have proposed phantom test procedures and criteria for optimizing image quality across different PET cameras...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27682837/technical-note-how-to-determine-the-fdg-activity-for-tumour-pet-imaging-that-satisfies-european-guidelines
#14
Daniëlle Koopman, Jochen A C van Osch, Pieter L Jager, Carlijn J A Tenbergen, Siert Knollema, Cornelis H Slump, Jorn A van Dalen
BACKGROUND: For tumour imaging with PET, the literature proposes to administer a patient-specific FDG activity that depends quadratically on a patient's body weight. However, a practical approach on how to implement such a protocol in clinical practice is currently lacking. We aimed to provide a practical method to determine a FDG activity formula for whole-body PET examinations that satisfies both the EANM guidelines and this quadratic relation. RESULTS: We have developed a methodology that results in a formula describing the patient-specific FDG activity to administer...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27654452/a-novel-planar-image-based-method-for-bone-marrow-dosimetry-in-177-lu-dotatate-treatment-correlates-with-haematological-toxicity
#15
Johanna Svensson, Tobias Rydén, Linn Hagmarker, Jens Hemmingsson, Bo Wängberg, Peter Bernhardt
BACKGROUND: (177)Lu-DOTATATE is a valuable treatment option for patients with advanced neuroendocrine tumours overexpressing somatostatin receptors. Though well tolerated in general, bone marrow toxicity can, besides renal exposure, become dose limiting and affect the ability to sustain future therapies. The aim of this study was to develop a novel planar image-based method for bone marrow dosimetry and evaluate its correlation with haematological toxicity during (177)Lu-DOTATATE treatment...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27576333/multimodality-calibration-for-simultaneous-fluoroscopic-and-nuclear-imaging
#16
Casper Beijst, Mattijs Elschot, Sandra van der Velden, Hugo W A M de Jong
BACKGROUND: Simultaneous real-time fluoroscopic and nuclear imaging could benefit image-guided (oncological) procedures. To this end, a hybrid modality is currently being developed by our group, by combining a c-arm with a gamma camera and a four-pinhole collimator. Accurate determination of the system parameters that describe the position of the x-ray tube, x-ray detector, gamma camera, and collimators is crucial to optimize image quality. The purpose of this study was to develop a calibration method that estimates the system parameters used for reconstruction...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27562024/an-overview-of-cest-mri-for-non-mr-physicists
#17
REVIEW
B Wu, G Warnock, M Zaiss, C Lin, M Chen, Z Zhou, L Mu, D Nanz, R Tuura, G Delso
The search for novel image contrasts has been a major driving force in the magnetic resonance (MR) research community, in order to gain further information on the body's physiological and pathological conditions.Chemical exchange saturation transfer (CEST) is a novel MR technique that enables imaging certain compounds at concentrations that are too low to impact the contrast of standard MR imaging and too low to directly be detected in MRS at typical water imaging resolution. For this to be possible, the target compound must be capable of exchanging protons with the surrounding water molecules...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27526050/a-robust-conversion-method-of-radioactivities-between-plastic-and-nai-scintillation-well-counters-for-long-term-quality-control-and-quality-assurance
#18
Takeshi Hara, Tadahiko Ishihara, Takahiko Asano, Masayuki Matsuo, Tetsuro Katafuchi, Hiroshi Fujita
PURPOSE: The purpose of this study is to specify a simple procedure for a robust data conversion of radioactivity value between plastic scintillator (PL) and NaI scintillator (NaI) devices. MATERIALS AND METHODS: The radioactivity estimate of 100 blood samples was measured by the two devices. The two radioactivities were plotted on the same graph. The least-squares method was applied to obtain the conversion function. The differences between the actual radioradioy (N) from the NaI device and the estimated radioactivity for NaI (N') from the PL device activity (P) were statistically analyzed...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27495914/abdo-man-a-3d-printed-anthropomorphic-phantom-for-validating-quantitative-sirt
#19
Jonathan I Gear, Craig Cummings, Allison J Craig, Antigoni Divoli, Clive D C Long, Michael Tapner, Glenn D Flux
BACKGROUND: The use of selective internal radiation therapy (SIRT) is rapidly increasing, and the need for quantification and dosimetry is becoming more widespread to facilitate treatment planning and verification. The aim of this project was to develop an anthropomorphic phantom that can be used as a validation tool for post-SIRT imaging and its application to dosimetry. METHOD: The phantom design was based on anatomical data obtained from a T1-weighted volume-interpolated breath-hold examination (VIBE) on a Siemens Aera 1...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27495913/effect-of-dosimeter-s-position-on-occupational-radiation-extremity-dose-measurement-for-nuclear-medicine-workers-during-18-f-fdg-preparation-for-pet-ct
#20
Fabien Salesses, Paul Perez, Aline E Maillard, Julie Blanchard, Sabine Mallard, Laurence Bordenave
BACKGROUND: The recent spread of positron emission tomography-computed tomography (PET/CT) poses extremity dosimetry challenges. The question arose whether the radiation dose measured by the ring thermoluminescent dosimeter usually worn on the proximal phalanx (P1) of the index finger measures doses that are representative of the true doses received by the upper extremities of the operators. A prospective individual dosimetry study was performed in which the personal equivalent dose Hp (0...
December 2016: EJNMMI Physics
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