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EJNMMI Physics

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https://www.readbyqxmd.com/read/30069805/inter-comparison-of-quantitative-imaging-of-lutetium-177-177-lu-in-european-hospitals
#1
Jill Wevrett, Andrew Fenwick, James Scuffham, Lena Johansson, Jonathan Gear, Susanne Schlögl, Marcel Segbers, Katarina Sjögreen-Gleisner, Pavel Solný, Michael Lassmann, Jill Tipping, Andrew Nisbet
BACKGROUND: This inter-comparison exercise was performed to demonstrate the variability of quantitative SPECT/CT imaging for lutetium-177 (177 Lu) in current clinical practice. Our aim was to assess the feasibility of using international inter-comparison exercises as a means to ensure consistency between clinical sites whilst enabling the sites to use their own choice of quantitative imaging protocols, specific to their systems. Dual-compartment concentric spherical sources of accurately known activity concentrations were prepared and sent to seven European clinical sites...
August 2, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30022353/quantitative-performance-of-124-i-pet-mr-of-neck-lesions-in-thyroid-cancer-patients-using-124-i-pet-ct-as-reference
#2
Walter Jentzen, Jinda Phaosricharoen, Benedikt Gomez, Philipp Hetkamp, Vanessa Stebner, Ina Binse, Sonja Kinner, Ken Herrmann, Amir Sabet, James Nagarajah
BACKGROUND: In patients with differentiated thyroid cancer (DTC), serial 124 I PET/CT imaging is, for instance, used to assess the absorbed (radiation) dose to lesions. Frequently, the lesions are located in the neck and they are close to or surrounded by different tissue types. In contrast to PET/CT, MR-based attenuation correction in PET/MR may be therefore challenging in the neck region. The aim of this retrospective study was to assess the quantitative performance of 124 I PET/MRI of neck lesions by comparing the MR-based and CT-based 124 I activity concentrations (ACs)...
July 19, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29974391/feasibility-of-simplifying-renal-dosimetry-in-177-lu-peptide-receptor-radionuclide-therapy
#3
Anna Sundlöv, Johan Gustafsson, Gustav Brolin, Nadja Mortensen, Rebecca Hermann, Peter Bernhardt, Johanna Svensson, Michael Ljungberg, Jan Tennvall, Katarina Sjögreen Gleisner
BACKGROUND: Recently, 177 Lu-dotatate therapy for neuroendocrine tumours has received regulatory approval. Dosimetry can be used to optimize treatment on an individual basis, but there is no international consensus as to how it should be done. The aim of this study is to determine a feasible and accurate dosimetry method to guide individualized peptide receptor radionuclide therapy (PRRT) for patients with neuroendocrine tumours. As part of a clinical trial on 177 Lu-dotatate therapy, renal dosimetry was performed for all patients in each treatment cycle, using a hybrid planar-SPECT/CT method...
July 5, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29956037/abstracts-of-the-total-body-pet-conference-2018-ghent-belgium-30-june-2-july-2018
#4
(no author information available yet)
No abstract text is available yet for this article.
June 29, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29916115/reducing-the-number-of-cts-performed-to-monitor-personalized-dosimetry-during-peptide-receptor-radionuclide-therapy-prrt
#5
Alexandre Chicheportiche, Faozi Artoul, Arnon Schwartz, Simona Grozinsky-Glasberg, Amichay Meirovitz, David J Gross, Jeremy Godefroy
BACKGROUND: Peptide receptor radionuclide therapy (PRRT) with [177 Lu]-DOTA-TATE is an effective treatment of neuroendocrine tumors (NETs). After each cycle of treatment, patient dosimetry evaluates the radiation dose to the risk organs, kidneys, and bone marrow, the most radiosensitive tissues. Absorbed doses are calculated from the radioactivity in the blood and from single photon emission computed tomography (SPECT) images corrected by computed tomography (CT) acquired after each course of treatment...
June 19, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29869186/improved-quantitation-and-reproducibility-in-multi-pet-ct-lung-studies-by-combining-ct-information
#6
Beverley F Holman, Vesna Cuplov, Lynn Millner, Raymond Endozo, Toby M Maher, Ashley M Groves, Brian F Hutton, Kris Thielemans
BACKGROUND: Matched attenuation maps are vital for obtaining accurate and reproducible kinetic and static parameter estimates from PET data. With increased interest in PET/CT imaging of diffuse lung diseases for assessing disease progression and treatment effectiveness, understanding the extent of the effect of respiratory motion and establishing methods for correction are becoming more important. In a previous study, we have shown that using the wrong attenuation map leads to large errors due to density mismatches in the lung, especially in dynamic PET scans...
June 5, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29766354/image-based-spect-calibration-based-on-the-evaluation-of-the-fraction-of-activity-in-the-field-of-view
#7
Adrien Halty, Jean-Noël Badel, Olga Kochebina, David Sarrut
BACKGROUND: SPECT quantification is important for dosimetry in targeted radionuclide therapy (TRT) and the calibration of SPECT images is a crucial stage for image quantification. The current standardized calibration protocol (MIRD 23) uses phantom acquisitions to derive a global calibration factor in specific conditions. It thus requires specific acquisitions for every clinical protocols. We proposed an alternative and complementary image-based calibration method that allows to determine a calibration factor adapted to each patient, radionuclide, and acquisition protocol and that may also be used as an additional independent calibration...
May 16, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29717385/determination-of-gamma-camera-calibration-factors-for-quantitation-of-therapeutic-radioisotopes
#8
Wei Zhao, Pedro L Esquinas, Xinchi Hou, Carlos F Uribe, Marjorie Gonzalez, Jean-Mathieu Beauregard, Yuni K Dewaraja, Anna Celler
BACKGROUND: Camera calibration, which translates reconstructed count map into absolute activity map, is a prerequisite procedure for quantitative SPECT imaging. Both planar and tomographic scans using different phantom geometries have been proposed for the determination of the camera calibration factor (CF). However, there is no consensus on which approach is the best. The aim of this study is to evaluate all these calibration methods, compare their performance, and propose a practical and accurate calibration method for SPECT quantitation of therapeutic radioisotopes...
May 2, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29666972/initial-experience-with-a-sipm-based-pet-ct-scanner-influence-of-acquisition-time-on-image-quality
#9
Ida Sonni, Lucia Baratto, Sonya Park, Negin Hatami, Shyam Srinivas, Guido Davidzon, Sanjiv Sam Gambhir, Andrei Iagaru
BACKGROUND: A newly introduced PET/CT scanner (Discovery Meaningful Insights-DMI, GE Healthcare) includes the silicon photomultiplier (SiPM) with time-of-flight (TOF) technology first used in the GE SIGNA PET/MRI. In this study, we investigated the impact of various acquisition times on image quality using this SiPM-based PET/CT. METHODS: We reviewed data from 58 participants with cancer who were scanned using the DMI PET/CT scanner. The administered dosages ranged 295...
April 18, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29616365/multi-institutional-quantitative-phantom-study-of-yttrium-90-pet-in-pet-mri-the-mr-quest-study
#10
Nichole M Maughan, Mootaz Eldib, David Faul, Maurizio Conti, Mattijs Elschot, Karin Knešaurek, Francesca Leek, David Townsend, Frank P DiFilippo, Kimberly Jackson, Stephan G Nekolla, Mathias Lukas, Michael Tapner, Parag J Parikh, Richard Laforest
BACKGROUND: Yttrium-90 (90 Y) radioembolization involves the intra-arterial delivery of radioactive microspheres to treat hepatic malignancies. Though this therapy involves careful pre-treatment planning and imaging, little is known about the precise location of the microspheres once they are administered. Recently, there has been growing interest post-radioembolization imaging using positron-emission tomography (PET) for quantitative dosimetry and identifying lesions that may benefit from additional salvage therapy...
April 4, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29536291/feasibility-study-of-a-novel-general-purpose-czt-based-digital-spect-camera-initial-clinical-results
#11
Elinor Goshen, Leonid Beilin, Eli Stern, Tal Kenig, Ronen Goldkorn, Simona Ben-Haim
BACKGROUND: The performance of a prototype novel digital single-photon emission computed tomography (SPECT) camera with multiple pixelated CZT detectors and high sensitivity collimators (Digital SPECT; Valiance X12 prototype, Molecular Dynamics) was evaluated in various clinical settings. Images obtained in the prototype system were compared to images from an analog camera fitted with high-resolution collimators. Clinical feasibility, image quality, and diagnostic performance of the prototype were evaluated in 36 SPECT studies in 35 patients including bone (n = 21), brain (n = 5), lung perfusion (n = 3), and parathyroid (n = 3) and one study each of sentinel node and labeled white blood cells...
March 14, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29492787/performance-evaluation-of-a-novel-brain-dedicated-spect-system
#12
M K Stam, E E Verwer, J Booij, S M Adriaanse, C M de Bruin, T C de Wit
No abstract text is available yet for this article.
March 1, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29460190/quantitative-analysis-of-phantom-studies-of-111-in-and-68-ga-imaging-of-neuroendocrine-tumours
#13
L Jönsson, A Stenvall, E Mattsson, E Larsson, A Sundlöv, T Ohlsson, C Hindorf
BACKGROUND: Nuclear medicine imaging of neuroendocrine tumours is performed either by SPECT/CT imaging, using 111 In-octreotide or by PET/CT imaging using 68 Ga-radiolabelled somatostatin analogs. These imaging techniques will give different image quality and different detection thresholds for tumours, depending on size and activity uptake. The aim was to evaluate the image quality for 111 In-SPECT and 68 Ga-PET imaging, i.e. the smallest volume possible to visualize for different source-to-background activity ratios...
February 20, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29388075/mr-based-motion-correction-for-cardiac-pet-parametric-imaging-a-simulation-study
#14
Rong Guo, Yoann Petibon, Yixin Ma, Georges El Fakhri, Kui Ying, Jinsong Ouyang
BACKGROUND: Both cardiac and respiratory motions bias the kinetic parameters measured by dynamic PET. The aim of this study was to perform a realistic positron emission tomography-magnetic resonance (PET-MR) simulation study using 4D XCAT to evaluate the impact of MR-based motion correction on the estimation of PET myocardial kinetic parameters using PET-MR. Dynamic activity distributions were obtained based on a one-tissue compartment model with realistic kinetic parameters and an arterial input function...
February 1, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29322344/deadtime-effects-in-quantification-of-177-lu-activity-for-radionuclide-therapy
#15
Carlos F Uribe, Pedro L Esquinas, Marjorie Gonzalez, Wei Zhao, Jesse Tanguay, Anna Celler
BACKGROUND: The aim of this study was to investigate the deadtime (DT) effects that are present in 177 Lu images acquired after radionuclide therapy injection, assess differences in DT based on the full spectrum and the photopeak-only measurements, and design a method to correct for the deadtime losses. A Siemens SymbiaT SPECT/CT camera with a medium energy collimator was used. A 295-mL bottle was placed off-center inside a large cylinder filled with water, and 177 Lu activity was sequentially added up to a maximum of 9...
January 11, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29302810/fast-gpu-based-monte-carlo-code-for-spect-ct-reconstructions-generates-improved-177-lu-images
#16
T Rydén, J Heydorn Lagerlöf, J Hemmingsson, I Marin, J Svensson, M Båth, P Gjertsson, P Bernhardt
BACKGROUND: Full Monte Carlo (MC)-based SPECT reconstructions have a strong potential for correcting for image degrading factors, but the reconstruction times are long. The objective of this study was to develop a highly parallel Monte Carlo code for fast, ordered subset expectation maximum (OSEM) reconstructions of SPECT/CT images. The MC code was written in the Compute Unified Device Architecture language for a computer with four graphics processing units (GPUs) (GeForce GTX Titan X, Nvidia, USA)...
January 4, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29247300/monte-carlo-based-quantitative-pinhole-spect-reconstruction-using-a-ray-tracing-back-projector
#17
Mikael Peterson, Johan Gustafsson, Michael Ljungberg
BACKGROUND: Monte Carlo simulations provide accurate models of nuclear medicine imaging systems as they can properly account for the full physics of photon transport. The accuracy of the model included in the maximum-likelihood-expectation-maximization (ML-EM) reconstruction limits the overall accuracy of the reconstruction results. In this paper, we present a Monte Carlo-based ML-EM reconstruction method for pinhole single-photon emission computed tomography (SPECT) that has been incorporated into the SIMIND Monte Carlo program...
December 15, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29230607/the-effect-of-high-count-rates-on-cardiac-perfusion-quantification-in-a-simultaneous-pet-mr-system-using-a-cardiac-perfusion-phantom
#18
Jim O' Doherty, Zacharias Chalampalakis, Paul Schleyer, Muhummad Sohaib Nazir, Amedeo Chiribiri, Paul K Marsden
BACKGROUND: PET-MRI is under investigation as a new strategy for quantitative myocardial perfusion imaging. Consideration is required as to the maximum scanner count rate in order to limit dead-time losses resulting from administered activity in the scanner field of view during the first pass of the radiotracer. RESULTS: We performed a decaying-source experiment to investigate the high count-rate performance of a PET-MR system (Siemens mMR) over the expected range of activities during a clinical study...
December 11, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29209862/model-selection-criteria-for-dynamic-brain-pet-studies
#19
Sandeep S V Golla, Sofie M Adriaanse, Maqsood Yaqub, Albert D Windhorst, Adriaan A Lammertsma, Bart N M van Berckel, Ronald Boellaard
BACKGROUND:  Several criteria exist to identify the optimal model for quantification of tracer kinetics. The purpose of this study was to evaluate the correspondence in kinetic model preference identification for brain PET studies among five model selection criteria: Akaike Information Criterion (AIC), AIC unbiased (AICC ), model selection criterion (MSC), Schwartz Criterion (SC), and F-test. MATERIALS AND METHODS: Six tracers were evaluated: [11 C]FMZ, [11 C]GMOM, [11 C]PK11195, [11 C]Raclopride, [18 F]FDG, and [11 C]PHT, including data from five subjects per tracer...
December 6, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29199391/variations-in-the-practice-of-molecular-radiotherapy-and-implementation-of-dosimetry-results-from-a-european-survey
#20
Katarina Sjögreen Gleisner, Emiliano Spezi, Pavel Solny, Pablo Minguez Gabina, Francesco Cicone, Caroline Stokke, Carlo Chiesa, Maria Paphiti, Boudewijn Brans, Mattias Sandström, Jill Tipping, Mark Konijnenberg, Glenn Flux
BACKGROUND: Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availability of dosimetry-based MRT in clinical practice and research studies. The aim of this study was to assess the current practice of MRT and dosimetry across European countries. METHODS: An electronic questionnaire was distributed to European countries...
December 4, 2017: EJNMMI Physics
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