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EJNMMI Physics

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https://www.readbyqxmd.com/read/30535780/predictive-power-of-the-post-treatment-scans-after-the-initial-or-first-two-courses-of-177-lu-dota-tate
#1
Alexandre Chicheportiche, Simona Grozinsky-Glasberg, David J Gross, Yodphat Krausz, Asher Salmon, Amichay Meirovitz, Nanette Freedman, Jeremy Godefroy
BACKGROUND: The aim of this study was to evaluate the predictive power of the absorbed dose to kidneys after the first course of treatment with [177 Lu]-DOTA-TATE for neuroendocrine tumors (NETs) on the cumulative kidney absorbed dose after 3 or 4 cycles of treatment. Post-treatment scans (PTS) are acquired after each cycle of peptide receptor radionuclide therapy (PRRT) with [177 Lu]-DOTA-TATE for personalized radiation dosimetry in order to ensure a cumulative absorbed dose to kidneys under a safety threshold of 25 Gy...
December 10, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30523435/biodistribution-pharmacokinetics-and-organ-level-dosimetry-for-188-re-ahdd-lipiodol-radioembolization-based-on-quantitative-post-treatment-spect-ct-scans
#2
Pedro L Esquinas, Ajit Shinto, Koramadai K Kamaleshwaran, Jephy Joseph, Anna Celler
BACKGROUND: Rhenium-188-labelled-Lipiodol radioembolization is a safe and cost-effective treatment for primary liver cancer. In order to determine correlations between treatment doses and patient response to therapy, accurate patient-specific dosimetry is required. Up to date, the reported dosimetry of 188 Re-Lipiodol has been based on whole-body (WB) planar imaging only, which has limited quantitative accuracy. The aim of the present study is to determine the in vivo pharmacokinetics, bio-distribution, and organ-level dosimetry of 188 Re-AHDD-Lipiodol radioembolization using a combination of post-treatment planar and quantitative SPECT/CT images...
December 7, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30523429/impact-of-pet-reconstruction-protocols-on-quantification-of-lesions-that-fulfil-the-percist-lesion-inclusion-criteria
#3
Joke Devriese, Laurence Beels, Alex Maes, Christophe Van de Wiele, Hans Pottel
BACKGROUND: The aim of this study was to compare liver and oncologic lesion standardized uptake values (SUV) obtained through two different reconstruction protocols, GE's newest clinical lesion detection protocol (Q.Clear) and the EANM Research Ltd (EARL) harmonization protocol, and to assess the clinical relevance of potential differences and possible implications for daily clinical practice using the PERCIST lesional inclusion criteria. NEMA phantom recovery coefficients (RC) and SUV normalized for lean body mass (LBM), referred to as SUV normalized for LBM (SUL), of liver and lesion volumes of interest were compared between the two reconstruction protocols...
December 7, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30519974/validation-of-the-physiological-background-correction-method-for-the-suppression-of-the-spill-in-effect-near-highly-radioactive-regions-in-positron-emission-tomography
#4
Mercy I Akerele, Palak Wadhwa, Jesus Silva-Rodriguez, William Hallett, Charalampos Tsoumpas
BACKGROUND: Positron emission tomography (PET) imaging has a wide applicability in oncology, cardiology and neurology. However, a major drawback when imaging very active regions such as the bladder is the spill-in effect, leading to inaccurate quantification and obscured visualisation of nearby lesions. Therefore, this study aims at investigating and correcting for the spill-in effect from high-activity regions to the surroundings as a function of activity in the hot region, lesion size and location, system resolution and application of post-filtering using a recently proposed background correction technique...
December 5, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30511121/fast-quantitative-reconstruction-with-focusing-collimators-for-liver-spect
#5
Martijn M A Dietze, Sandra van der Velden, Marnix G E H Lam, Max A Viergever, Hugo W A M de Jong
BACKGROUND: Generation of a SPECT scan during procedure may aid in the optimization of treatments as liver radioembolization by offering image-guided dosimetry. This, however, requires both shortened acquisition times and fast quantitative reconstruction. Focusing collimators increase sensitivity and thus may speed up imaging. Monte Carlo-based iterative reconstruction has shown to provide quantitative results for parallel hole collimators but may be slow. The purpose of this work is to develop fast Monte Carlo-based reconstruction for focusing collimators and to evaluate the impact of reconstruction and collimator choice on quantitative accuracy of liver dosimetry by means of simulations...
December 4, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30506174/performance-evaluation-of-a-new-high-sensitivity-time-of-flight-clinical-pet-ct-system
#6
Li Huo, Nan Li, Heyu Wu, Wenjia Zhu, Haiqun Xing, Jiantao Ba, Tong Wang, Fang Li, Hui Zhang
BACKGROUND: PoleStar m660 is a newly developed clinical PET/CT system with time-of-flight (TOF) capability. The aim of this study is to characterize the performance of the new system. Spatial resolution, sensitivity, scatter fraction, and noise equivalent count rate (NECR) were measured on the scanner according to the NEMA NU 2-2012 protocol. The timing resolution was measured using a rotating line source that orbited around the center of field of view (CFOV) at a radius of 20 cm. The image quality phantom was also imaged to quantify the percent contrast, percent background variability, and residual error...
December 1, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30498973/impact-of-90-y-pet-gradient-based-tumor-segmentation-on-voxel-level-dosimetry-in-liver-radioembolization
#7
Justin K Mikell, Ravi K Kaza, Peter L Roberson, Kelly C Younge, Ravi N Srinivasa, Bill S Majdalany, Kyle C Cuneo, Dawn Owen, Theresa Devasia, Matthew J Schipper, Yuni K Dewaraja
BACKGROUND: The purpose was to validate 90 Y PET gradient-based tumor segmentation in phantoms and to evaluate the impact of the segmentation method on reported tumor absorbed dose (AD) and biological effective dose (BED) in 90 Y microsphere radioembolization (RE) patients. A semi-automated gradient-based method was applied to phantoms and patient tumors on the 90 Y PET with the initial bounding volume for gradient detection determined from a registered diagnostic CT or MR; this PET-based segmentation (PS) was compared with radiologist-defined morphologic segmentation (MS) on CT or MRI...
November 30, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30460577/feasibility-of-pet-ct-system-performance-harmonisation-for-quantitative-multicentre-89-zr-studies
#8
Andres Kaalep, Marc Huisman, Terez Sera, Danielle Vugts, Ronald Boellaard
PURPOSE: The aim of this study was to investigate the variability in quantitative performance and feasibility of quantitative harmonisation in 89 Zr PET/CT imaging. METHODS: Eight EANM EARL-accredited (Kaalep A et al., Eur J Nucl Med Mol Imaging 45:412-22, 2018) PET/CT systems were investigated using phantom acquisitions of uniform and NEMA NU2-2007 body phantoms. The phantoms were filled according to EANM EARL guidelines for [18 F]FDG, but [18 F]FDG solution was replaced by a 89 Zr calibration mixture...
November 21, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30417316/a-deep-learning-approach-for-18-f-fdg-pet-attenuation-correction
#9
Fang Liu, Hyungseok Jang, Richard Kijowski, Gengyan Zhao, Tyler Bradshaw, Alan B McMillan
BACKGROUND: To develop and evaluate the feasibility of a data-driven deep learning approach (deepAC) for positron-emission tomography (PET) image attenuation correction without anatomical imaging. A PET attenuation correction pipeline was developed utilizing deep learning to generate continuously valued pseudo-computed tomography (CT) images from uncorrected 18 F-fluorodeoxyglucose (18 F-FDG) PET images. A deep convolutional encoder-decoder network was trained to identify tissue contrast in volumetric uncorrected PET images co-registered to CT data...
November 12, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30386924/the-physics-of-radioembolization
#10
REVIEW
Remco Bastiaannet, S Cheenu Kappadath, Britt Kunnen, Arthur J A T Braat, Marnix G E H Lam, Hugo W A M de Jong
Radioembolization is an established treatment for chemoresistant and unresectable liver cancers. Currently, treatment planning is often based on semi-empirical methods, which yield acceptable toxicity profiles and have enabled the large-scale application in a palliative setting. However, recently, five large randomized controlled trials using resin microspheres failed to demonstrate a significant improvement in either progression-free survival or overall survival in both hepatocellular carcinoma and metastatic colorectal cancer...
November 2, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30345471/evaluation-of-zero-echo-time-attenuation-correction-for-integrated-pet-mr-brain-imaging-comparison-to-head-atlas-and-68-ge-transmission-based-attenuation-correction
#11
João M Sousa, Lieuwe Appel, Mathias Engström, Stergios Papadimitriou, Dag Nyholm, Elna-Marie Larsson, Håkan Ahlström, Mark Lubberink
BACKGROUND: MRI does not offer a direct method to obtain attenuation correction maps as its predecessors (stand-alone PET and PET/CT), and bone visualisation is particularly challenging. Recently, zero-echo-time (ZTE) was suggested for MR-based attenuation correction (AC). The aim of this work was to evaluate ZTE- and atlas-AC by comparison to 68 Ge-transmission scan-based AC. Nine patients underwent brain PET/MR and stand-alone PET scanning using the dopamine transporter ligand 11 C-PE2I...
October 22, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30318563/accuracy-and-reproducibility-of-simplified-qspect-dosimetry-for-personalized-177-lu-octreotate-prrt
#12
Michela Del Prete, Frédéric Arsenault, Nassim Saighi, Wei Zhao, François-Alexandre Buteau, Anna Celler, Jean-Mathieu Beauregard
BACKGROUND: Routine dosimetry is essential for personalized 177 Lu-octreotate peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs), but practical and robust dosimetry methods are needed for wide clinical adoption. The aim of this study was to assess the accuracy and inter-observer reproducibility of simplified dosimetry protocols based on quantitative single-photon emission computed tomography (QSPECT) with a limited number of scanning time points. We also updated our personalized injected activity (IA) prescription scheme...
October 15, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30294746/validation-of-gallbladder-absorbed-radiation-dose-reduction-simulation-human-dosimetry-of-18-f-fluortriopride
#13
Robert K Doot, Jacob G Dubroff, Joshua S Scheuermann, Kyle J Labban, Jenny Cai, Chia-Ju Hsieh, Shihong Li, Hsiaoju Lee, Erin K Schubert, Catherine Hou, Regan Sheffer, Alexander Schmitz, Kuiying Xu, Robert H Mach
BACKGROUND: [18 F]Fluortriopride (FTP) was developed as a dopamine D3-selective radiotracer, thought to be important to neurobiological reward pathways and implicated in drug addiction, Parkinson's disease, and schizophrenia. Preclinical radiation dosimetry studies found the gallbladder wall received the highest dose. A gallbladder dose reduction intervention was simulated using a novel reduction model for healthy adults following fatty-meal consumption. The goals of this study were to assess whole body FTP human dosimetry and determine the feasibility of reducing absorbed dose to the gallbladder wall...
October 8, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30255439/impact-of-a-bayesian-penalized-likelihood-reconstruction-algorithm-on-image-quality-in-novel-digital-pet-ct-clinical-implications-for-the-assessment-of-lung-tumors
#14
Michael Messerli, Paul Stolzmann, Michèle Egger-Sigg, Josephine Trinckauf, Stefano D'Aguanno, Irene A Burger, Gustav K von Schulthess, Philipp A Kaufmann, Martin W Huellner
BACKGROUND: The aim of this study was to evaluate and compare PET image reconstruction algorithms on novel digital silicon photomultiplier PET/CT in patients with newly diagnosed and histopathologically confirmed lung cancer. A total of 45 patients undergoing 18F-FDG PET/CT for initial lung cancer staging were included. PET images were reconstructed using ordered subset expectation maximization (OSEM) with time-of-flight and point spread function modelling as well as Bayesian penalized likelihood reconstruction algorithm (BSREM) with different β-values yielding a total of 7 datasets per patient...
September 26, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30225675/smart-simulation-and-reconstruction-pet-an-efficient-pet-simulation-reconstruction-tool
#15
Elisabeth Pfaehler, Johan R De Jong, Rudi A J O Dierckx, Floris H P van Velden, Ronald Boellaard
BACKGROUND: Positron-emission tomography (PET) simulators are frequently used for development and performance evaluation of segmentation methods or quantitative uptake metrics. To date, most PET simulation tools are based on Monte Carlo simulations, which are computationally demanding. Other analytical simulation tools lack the implementation of time of flight (TOF) or resolution modelling (RM). In this study, a fast and easy-to-use PET simulation-reconstruction package, SiMulAtion and ReconsTruction (SMART)-PET, is developed and validated, which includes both TOF and RM...
September 18, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30175390/comparison-of-radiobiological-parameters-for-90-y-radionuclide-therapy-rnt-and-external-beam-radiotherapy-ebrt-in-vitro
#16
Yaser H Gholami, Kathy P Willowson, Nicholas J Forwood, Rozelle Harvie, Nicholas Hardcastle, Regina Bromley, HyunJu Ryu, Samuel Yuen, Viive M Howell, Zdenka Kuncic, Dale L Bailey
BACKGROUND: Dose rate variation is a critical factor affecting radionuclide therapy (RNT) efficacy. Relatively few studies to date have investigated the dose rate effect in RNT. Therefore, the aim of this study was to benchmark 90 Y RNT (at different dose rates) against external beam radiotherapy (EBRT) in vitro and compare cell kill responses between the two irradiation processes. RESULTS: Three human colorectal carcinoma (CRC) cell lines (HT29, HCT116, SW48) were exposed to 90 Y doses in the ranges 1-10...
September 3, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30159638/comparison-of-pet-ct-and-pet-mr-imaging-and-dosimetry-of-yttrium-90-90-y-in-patients-with-unresectable-hepatic-tumors-who-have-received-intra-arterial-radioembolization-therapy-with-90-y-microspheres
#17
Karin Knešaurek, Abbas Tuli, Edward Kim, Sherif Heiba, Lale Kostakoglu
BACKGROUND: The aim of our study was to compare 90 Y dosimetry obtained from PET/MRI versus PET/CT post-therapy imaging among patients with primary or metastatic hepatic tumors. First, a water-filled Jaszczak phantom containing fillable sphere with 90 Y-chloride was acquired on both the PET/CT and PET/MRI systems, in order to check the cross-calibration of the modalities. Following selective internal radiation therapy (SIRT) with 90 Y microspheres, 32 patients were imaged on a PET/CT system, immediately followed by a PET/MRI study...
August 30, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30146662/molecular-imaging-using-the-theranostic-agent-197-m-hg-phantom-measurements-and-monte-carlo-simulations
#18
Robert Freudenberg, Rudi Apolle, Martin Walther, Holger Hartmann, Jörg Kotzerke
BACKGROUND: Radiomercury 197m Hg and 197 Hg, henceforth referred to as 197(m) Hg, is a promising theranostic radionuclide endowed with properties that allow diagnostic and therapeutic applications. The aim of this work was to investigate the capabilities of 197(m) Hg for nuclear medicine imaging. Therefore measurements were performed by using a Philips BrightView SPECT camera. Furthermore, Monte Carlo simulations using the GATE software were performed to theoretically explore the imaging contribution from the various gamma and X-ray emissions from 197(m) Hg for a commercial clinical camera with low-energy high-resolution (LEHR) and high-energy general-purpose (HEGP) collimators...
August 27, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30069805/inter-comparison-of-quantitative-imaging-of-lutetium-177-177-lu-in-european-hospitals
#19
Jill Wevrett, Andrew Fenwick, James Scuffham, Lena Johansson, Jonathan Gear, Susanne Schlögl, Marcel Segbers, Katarina Sjögreen-Gleisner, Pavel Solný, Michael Lassmann, Jill Tipping, Andrew Nisbet
BACKGROUND: This inter-comparison exercise was performed to demonstrate the variability of quantitative SPECT/CT imaging for lutetium-177 (177 Lu) in current clinical practice. Our aim was to assess the feasibility of using international inter-comparison exercises as a means to ensure consistency between clinical sites whilst enabling the sites to use their own choice of quantitative imaging protocols, specific to their systems. Dual-compartment concentric spherical sources of accurately known activity concentrations were prepared and sent to seven European clinical sites...
August 2, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30022353/quantitative-performance-of-124-i-pet-mr-of-neck-lesions-in-thyroid-cancer-patients-using-124-i-pet-ct-as-reference
#20
Walter Jentzen, Jinda Phaosricharoen, Benedikt Gomez, Philipp Hetkamp, Vanessa Stebner, Ina Binse, Sonja Kinner, Ken Herrmann, Amir Sabet, James Nagarajah
BACKGROUND: In patients with differentiated thyroid cancer (DTC), serial 124 I PET/CT imaging is, for instance, used to assess the absorbed (radiation) dose to lesions. Frequently, the lesions are located in the neck and they are close to or surrounded by different tissue types. In contrast to PET/CT, MR-based attenuation correction in PET/MR may be therefore challenging in the neck region. The aim of this retrospective study was to assess the quantitative performance of 124 I PET/MRI of neck lesions by comparing the MR-based and CT-based 124 I activity concentrations (ACs)...
July 19, 2018: EJNMMI Physics
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