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Diagnostics

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https://www.readbyqxmd.com/read/28282907/complications-from-surgeries-related-to-ovarian-cancer-screening
#1
Lauren A Baldwin, Edward J Pavlik, Emma Ueland, Hannah E Brown, Kelsey M Ladd, Bin Huang, Christopher P DeSimone, John R van Nagell, Frederick R Ueland, Rachel W Miller
The aim of this study was to evaluate complications of surgical intervention for participants in the Kentucky Ovarian Cancer Screening Program and compare results to those of the Prostate, Lung, Colorectal and Ovarian Cancer Screening trial. A retrospective database review included 657 patients who underwent surgery for a positive screen in the Kentucky Ovarian Cancer Screening Program from 1988-2014. Data were abstracted from operative reports, discharge summaries, and office notes for 406 patients. Another 142 patients with incomplete records were interviewed by phone...
March 8, 2017: Diagnostics
https://www.readbyqxmd.com/read/28282875/a-perspective-on-ovarian-cancer-biomarkers-past-present-and-yet-to-come
#2
Frederick R Ueland
The history of biomarkers and ultrasonography dates back over more than 50 years. The present status of biomarkers used in the context of ovarian cancer is addressed. Attention is given to new interpretations of the etiology of ovarian cancer. Cancer antigen 125 (CA125) and multivariate index assays (Ova1, Risk of Ovarian Malignancy Algorithm, Overa) are biomarker-driven considerations that are presented. Integration of biomarkers into ovarian cancer diagnostics and screening are presented in conjunction with ultrasound...
March 8, 2017: Diagnostics
https://www.readbyqxmd.com/read/28282847/psychological-and-behavioral-impact-of-participation-in-ovarian-cancer-screening
#3
REVIEW
Michael A Andrykowski
Evaluation of costs and benefits associated with cancer screening should include consideration of any psychological and behavioral impact associated with screening participation. Research examining the psychological and behavioral impact of screening asymptomatic women for ovarian cancer (OC) was considered. Research has focused upon potential negative psychological (e.g., distress) and behavioral (e.g., reduced future screening participation) impact of false positive (FP) OC test results. Results suggest FP OC screening results are associated with greater short-term OC-specific distress...
March 8, 2017: Diagnostics
https://www.readbyqxmd.com/read/28273857/improving-the-quality-of-diagnostic-studies-evaluating-point-of-care-tests-for-acute-hiv-infections-problems-and-recommendations
#4
Megan Smallwood, Nitika Pant Pai
The diagnosis of acute human immunodeficiency virus (HIV) infection (AHI) plays a unique role in preventing the spread of HIV and ending the epidemic. Acutely infected individuals are thought to contribute substantially to forward transmissions of HIV; however, diagnosing AHI in resource-limited settings has proven to be a challenge. While fourth generation antigen-antibody combination assays have been successful in high-resource settings, rapid point of care (POC) versions of these assays have yet to demonstrate high sensitivity to detect AHI...
March 4, 2017: Diagnostics
https://www.readbyqxmd.com/read/28257098/subtypes-of-ovarian-cancer-and-ovarian-cancer-screening
#5
REVIEW
Masafumi Koshiyama, Noriomi Matsumura, Ikuo Konishi
Ovarian cancer is the foremost cause of gynecological cancer death in the developed world, as it is usually diagnosed at an advanced stage. In this paper we discuss current issues, the efficacy and problems associated with ovarian cancer screening, and compare the characteristics of ovarian cancer subtypes. There are two types of ovarian cancer: Type I carcinomas, which are slow-growing, indolent neoplasms thought to arise from a precursor lesion, which are relatively common in Asia; and Type II carcinomas, which are clinically aggressive neoplasms that can develop de novo from serous tubal intraepithelial carcinomas (STIC) and/or ovarian surface epithelium and are common in Europe and the USA...
March 2, 2017: Diagnostics
https://www.readbyqxmd.com/read/28257064/a-pilot-study-into-the-association-between-oral-health-status-and-human-papillomavirus-16-infection
#6
Charles Xiaohang Sun, Nigel Bennett, Peter Tran, Kai Dun Tang, Yenkai Lim, Ian Frazer, Lakshman Samaranayake, Chamindie Punyadeera
BACKGROUND: Over the next 20 years, oropharyngeal cancers (OPC) will represent the majority of head and neck cancers (HNCs) in the United States. It is estimated that human papillomavirus (HPV) may account for as much as 70% to 80% of OPCs in North America and in certain parts of Europe. It is hence crucial to understand the disease risk factors and natural history of oral HPV infections. We hypothesized that poor oral health (by measures such as poor oral hygiene and periodontal disease) leads to a higher degree of oral HPV-16 infections within a patient cohort from a dental school clinic...
March 1, 2017: Diagnostics
https://www.readbyqxmd.com/read/28212290/defining-clinical-response-criteria-and-early-response-criteria-for-precision-oncology-current-state-of-the-art-and-future-perspectives
#7
Vivek Subbiah, Hubert H Chuang, Dhiraj Gambhire, Kalevi Kairemo
In this era of precision oncology, there has been an exponential growth in the armamentarium of genomically targeted therapies and immunotherapies. Evaluating early responses to precision therapy is essential for "go" versus "no go" decisions for these molecularly targeted drugs and agents that arm the immune system. Many different response assessment criteria exist for use in solid tumors and lymphomas. We reviewed the literature using the Medline/PubMed database for keywords "response assessment" and various known response assessment criteria published up to 2016...
February 15, 2017: Diagnostics
https://www.readbyqxmd.com/read/28216571/multivariate-feature-selection-of-image-descriptors-data-for-breast-cancer-with-computer-assisted-diagnosis
#8
Carlos E Galván-Tejada, Laura A Zanella-Calzada, Jorge I Galván-Tejada, José M Celaya-Padilla, Hamurabi Gamboa-Rosales, Idalia Garza-Veloz, Margarita L Martinez-Fierro
Breast cancer is an important global health problem, and the most common type of cancer among women. Late diagnosis significantly decreases the survival rate of the patient; however, using mammography for early detection has been demonstrated to be a very important tool increasing the survival rate. The purpose of this paper is to obtain a multivariate model to classify benign and malignant tumor lesions using a computer-assisted diagnosis with a genetic algorithm in training and test datasets from mammography image features...
February 14, 2017: Diagnostics
https://www.readbyqxmd.com/read/28134750/exploring-the-case-for-a-global-alliance-for-medical-diagnostics-initiative
#9
REVIEW
Melissa L Mugambi, Kara M Palamountain, Jim Gallarda, Paul K Drain
In recent years, the private and public sectors have increased investments in medical diagnostics for low- and middle-income countries (LMICs). Despite these investments, numerous barriers prevent the adoption of existing diagnostics and discourage the development and introduction of new diagnostics in LMICs. In the late 1990s, the global vaccine community had similar challenges, as vaccine coverage rates stagnated and the introduction of new vaccines was viewed as a distraction to delivering existing vaccines...
January 26, 2017: Diagnostics
https://www.readbyqxmd.com/read/28117682/salivary-diagnostics-point-of-care-diagnostics-of-mmp-8-in-dentistry-and-medicine
#10
REVIEW
Nilminie Rathnayake, Dirk-Rolf Gieselmann, Anna Maria Heikkinen, Taina Tervahartiala, Timo Sorsa
Human saliva is an easily accessible biological fluid and contains a variety of disease-related biomarkers, which makes it a potential diagnostic medium. The clinical use of salivary/oral fluid biomarkers to identify oral and systemic conditions requires the development of non-invasive screening and diagnostic technologies, and is among the main goals of oral fluid researchers. The analysis of the disease-specific oral and systemic biomarkers in saliva and oral fluids (i.e., mouth-rinse, gingival crevicular fluid (GCF) and peri-implantitis sulcular fluid (PISF)) is demanding...
January 20, 2017: Diagnostics
https://www.readbyqxmd.com/read/28106717/air-embolism-diagnosis-clinical-management-and-outcomes
#11
Colin J McCarthy, Sasan Behravesh, Sailendra G Naidu, Rahmi Oklu
Air embolism is a rare but potentially fatal complication of surgical procedures. Rapid recognition and intervention is critical for reducing morbidity and mortality. We retrospectively characterized our experience with air embolism during medical procedures at a tertiary medical center. Electronic medical records were searched for all cases of air embolism over a 25-year period; relevant medical and imaging records were reviewed. Sixty-seven air embolism cases were identified; the mean age was 59 years (range, 3-89 years)...
January 17, 2017: Diagnostics
https://www.readbyqxmd.com/read/28106714/a-promising-future-for-prostate-cancer-diagnostics
#12
EDITORIAL
Stephen J Assinder, Vanitha Bhoopalan
It has been estimated that globally there is a death attributable to prostate cancer every four minutes. As life expectancy in all world regions increases, so too incidence of this disease of the ageing male will increase. For many men diagnosis occurs after presentation with symptoms of altered urinary dynamics. Unfortunately, these changes, whilst also associated with benign disease, are evident quite late in the aetiology of prostate cancer. Early detection provides for better management and prognosis. This Special Issue provides an up to date view of the advances made towards early diagnosis and prognosis...
January 17, 2017: Diagnostics
https://www.readbyqxmd.com/read/28075337/implementation-of-point-of-care-diagnostics-in-rural-primary-healthcare-clinics-in-south-africa-perspectives-of-key-stakeholders
#13
Tivani P Mashamba-Thompson, Ngcwalisa A Jama, Benn Sartorius, Paul K Drain, Rowan M Thompson
INTRODUCTION: Key stakeholders' involvement is crucial to the sustainability of quality point-of-care (POC) diagnostics services in low-and-middle income countries. The aim of this study was to explore key stakeholder perceptions on the implementation of POC diagnostics in rural primary healthcare (PHC) clinics in South Africa. METHOD: We conducted a qualitative study encompassing in-depth interviews with multiple key stakeholders of POC diagnostic services for rural and resource-limited PHC clinics...
January 8, 2017: Diagnostics
https://www.readbyqxmd.com/read/28035946/diagnostics-strategies-with-electrochemical-affinity-biosensors-using-carbon-nanomaterials-as-electrode-modifiers
#14
REVIEW
Susana Campuzano, Paloma Yáñez-Sedeño, José M Pingarrón
Early diagnosis is often the key to successful patient treatment and survival. The identification of various disease signaling biomarkers which reliably reflect normal and disease states in humans in biological fluids explain the burgeoning research field in developing new methodologies able to determine the target biomarkers in complex biological samples with the required sensitivity and selectivity and in a simple and rapid way. The unique advantages offered by electrochemical sensors together with the availability of high affinity and specific bioreceptors and their great capabilities in terms of sensitivity and stability imparted by nanostructuring the electrode surface with different carbon nanomaterials have led to the development of new electrochemical biosensing strategies that have flourished as interesting alternatives to conventional methodologies for clinical diagnostics...
December 26, 2016: Diagnostics
https://www.readbyqxmd.com/read/28025506/fatty-acids-in-membranes-as-homeostatic-metabolic-and-nutritional-biomarkers-recent-advancements-in-analytics-and-diagnostics
#15
REVIEW
Carla Ferreri, Annalisa Masi, Anna Sansone, Giorgia Giacometti, Anna Vita Larocca, Georgia Menounou, Roberta Scanferlato, Silvia Tortorella, Domenico Rota, Marco Conti, Simone Deplano, Maria Louka, Anna Rosaria Maranini, Arianna Salati, Valentina Sunda, Chryssostomos Chatgilialoglu
Fatty acids, as structural components of membranes and inflammation/anti-inflammatory mediators, have well-known protective and regulatory effects. They are studied as biomarkers of pathological conditions, as well as saturated and unsaturated hydrophobic moieties in membrane phospholipids that contribute to homeostasis and physiological functions. Lifestyle, nutrition, metabolism and stress-with an excess of radical and oxidative processes-cause fatty acid changes that are examined in the human body using blood lipids...
December 22, 2016: Diagnostics
https://www.readbyqxmd.com/read/27999326/oral-biofluid-biomarker-research-current-status-and-emerging-frontiers
#16
REVIEW
Austin Wang, Chris P Wang, Michael Tu, David T W Wong
Salivary diagnostics is a rapidly advancing field that offers clinicians and patients the potential of rapid, noninvasive diagnostics with excellent accuracy. In order for the complete realization of the potential of saliva, however, extensive profiling of constituents must be conducted and diagnostic biomarkers must be thoroughly validated. This article briefly overviews the process of conducting a study of salivary biomarkers in a patient cohort and highlights the studies that have been conducted on different classes of molecules in the saliva...
December 17, 2016: Diagnostics
https://www.readbyqxmd.com/read/27916795/first-and-second-line-targeted-systemic-therapy-in-hepatocellular-carcinoma-an-update-on-patient-selection-and-response-evaluation
#17
REVIEW
Johann von Felden, Kornelius Schulze, Ines Gil-Ibanez, Tobias Werner, Henning Wege
Advanced hepatocellular carcinoma (HCC) with vascular invasion and/or extrahepatic spread and preserved liver function, according to stage C of the Barcelona Clinic Liver Cancer (BCLC) classification, has a dismal prognosis. The multi-targeted tyrosine-kinase receptor inhibitor (TKI) sorafenib is the only proven active substance in systemic HCC therapy for first-line treatment. In this review, we summarize current aspects in patient selection and management of side effects, and provide an update on response evaluation during first-line sorafenib therapy...
November 28, 2016: Diagnostics
https://www.readbyqxmd.com/read/27879660/gold-nanoparticles-for-diagnostics-advances-towards-points-of-care
#18
REVIEW
Mílton Cordeiro, Fábio Ferreira Carlos, Pedro Pedrosa, António Lopez, Pedro Viana Baptista
The remarkable physicochemical properties of gold nanoparticles (AuNPs) have prompted developments in the exploration of biomolecular interactions with AuNP-containing systems, in particular for biomedical applications in diagnostics. These systems show great promise in improving sensitivity, ease of operation and portability. Despite this endeavor, most platforms have yet to reach maturity and make their way into clinics or points of care (POC). Here, we present an overview of emerging and available molecular diagnostics using AuNPs for biomedical sensing that are currently being translated to the clinical setting...
November 22, 2016: Diagnostics
https://www.readbyqxmd.com/read/27869719/targeted-molecular-imaging-in-adrenal-disease-an-emerging-role-for-metomidate-pet-ct
#19
REVIEW
Iosif A Mendichovszky, Andrew S Powlson, Roido Manavaki, Franklin I Aigbirhio, Heok Cheow, John R Buscombe, Mark Gurnell, Fiona J Gilbert
Adrenal lesions present a significant diagnostic burden for both radiologists and endocrinologists, especially with the increasing number of adrenal 'incidentalomas' detected on modern computed tomography (CT) or magnetic resonance imaging (MRI). A key objective is the reliable distinction of benign disease from either primary adrenal malignancy (e.g., adrenocortical carcinoma or malignant forms of pheochromocytoma/paraganglioma (PPGL)) or metastases (e.g., bronchial, renal). Benign lesions may still be associated with adverse sequelae through autonomous hormone hypersecretion (e...
November 18, 2016: Diagnostics
https://www.readbyqxmd.com/read/27869666/gingival-crevicular-fluid-as-a-novel-potential-source-of-biomarkers-distinguishes-pubertal-from-post-pubertal-subjects
#20
Xi Wen, Yan Gu, Feng Chen
Detection of pubertal growth peak is vital in orthodontic treatment timing and planning. Gingival crevicular fluid (GCF) contains abundant proteins from different sources and has been proven to be an ideal source of biomarkers. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) is an advanced technique that can detect low-molecular-weight peptides with high sensitivity and resolution. The aim of this research was to identify novel candidate biomarkers in GCF to help the diagnosis of pubertal growth peak by MALDI-TOF/MS...
November 17, 2016: Diagnostics
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