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https://www.readbyqxmd.com/read/28925968/recent-progress-in-the-development-of-diagnostic-tests-for-malaria
#1
REVIEW
Francis D Krampa, Yaw Aniweh, Gordon A Awandare, Prosper Kanyong
The impact of malaria on global health has continually prompted the need to develop effective diagnostic strategies. In malaria endemic regions, routine diagnosis is hampered by technical and infrastructural challenges to laboratories. These laboratories lack standard facilities, expertise or diagnostic supplies; thus, therapy is administered based on clinical or self-diagnosis. There is the need for accurate diagnosis of malaria due to the continuous increase in the cost of medication, and the emergence and spread of drug resistant strains...
September 19, 2017: Diagnostics
https://www.readbyqxmd.com/read/28914777/the-usefulness-of-contrast-enhanced-ultrasound-in-the-assessment-of-early-kidney-transplant-function-and-complications
#2
REVIEW
Sara Álvarez Rodríguez, Vital Hevia Palacios, Enrique Sanz Mayayo, Victoria Gómez Dos Santos, Víctor Díez Nicolás, María Dolores Sánchez Gallego, Javier Lorca Álvaro, Francisco Javier Burgos Revilla
OBJECTIVES: The routine diagnostic method for assessment of renal graft dysfunction is Doppler ultrasound. However, contrast-enhanced ultrasound (CEUS) may provide more information about parenchymal flow and vascular status of kidney allografts. The aim of the study was to assess the effectiveness of CEUS in the immediate post-transplant period, focusing on acute vascular complications. A brief review of available literature and a report of our initial experience is made. MATERIAL AND METHODS: 15 kidney transplant (KT) cases with clinical suspicion of acute surgical complication were assessed with CEUS and conventional Doppler ultrasound (US)...
September 15, 2017: Diagnostics
https://www.readbyqxmd.com/read/28880218/development-of-multiplexed-infectious-disease-lateral-flow-assays-challenges-and-opportunities
#3
REVIEW
Khayriyyah Mohd Hanafiah, Norsyahida Arifin, Yazmin Bustami, Rahmah Noordin, Mary Garcia, David Anderson
Lateral flow assays (LFAs) are the mainstay of rapid point-of-care diagnostics, with the potential to enable early case management and transform the epidemiology of infectious disease. However, most LFAs only detect single biomarkers. Recognizing the complex nature of human disease, overlapping symptoms and states of co-infections, there is increasing demand for multiplexed systems that can detect multiple biomarkers simultaneously. Due to innate limitations in the design of traditional membrane-based LFAs, multiplexing is arguably limited to a small number of biomarkers...
September 7, 2017: Diagnostics
https://www.readbyqxmd.com/read/28869500/using-na%C3%A3-ve-bayesian-analysis-to-determine-imaging-characteristics-of-kras-mutations-in-metastatic-colon-cancer
#4
Yash Pershad, Siddharth Govindan, Amy K Hara, Mitesh J Borad, Tanios Bekaii-Saab, Alex Wallace, Hassan Albadawi, Rahmi Oklu
Genotype, particularly Ras status, greatly affects prognosis and treatment of liver metastasis in colon cancer patients. This pilot aimed to apply word frequency analysis and a naive Bayes classifier on radiology reports to extract distinguishing imaging descriptors of wild-type colon cancer patients and those with v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations. In this institutional-review-board-approved study, we compiled a SNaPshot mutation analysis dataset from 457 colon adenocarcinoma patients...
September 2, 2017: Diagnostics
https://www.readbyqxmd.com/read/28841167/-18-f-fdg-pet-ct-findings-in-a-patient-with-chikungunya-virus-infection
#5
Michala Vaaben Rose, Anna Sophie L Kjaer, Elena Markova, Jesper Graff
We present a case demonstrating the diagnostic work-up and follow-up of a patient with Chikungunya infection. An (18)F-FDG PET/CT performed four weeks after debut of symptoms revealed pathological (18)F-FDG uptake in enlarged lymph nodes on both side of the diaphragm, and inflammation of both shoulder and hip joints. Lymphoma and infection were the main differential diagnoses. Follow-up (18)F-FDG PET/CT scan in the patient performed 14 weeks after the abnormal scan, revealed almost complete resolution of the metabolically active disease...
August 25, 2017: Diagnostics
https://www.readbyqxmd.com/read/28837092/incorporating-oxygen-enhanced-mri-into-multi-parametric-assessment-of-human-prostate-cancer
#6
Heling Zhou, Rami R Hallac, Qing Yuan, Yao Ding, Zhongwei Zhang, Xian-Jin Xie, Franto Francis, Claus G Roehrborn, R Douglas Sims, Daniel N Costa, Ganesh V Raj, Ralph P Mason
Hypoxia is associated with prostate tumor aggressiveness, local recurrence, and biochemical failure. Magnetic resonance imaging (MRI) offers insight into tumor pathophysiology and recent reports have related transverse relaxation rate (R₂*) and longitudinal relaxation rate (R₁) measurements to tumor hypoxia. We have investigated the inclusion of oxygen-enhanced MRI for multi-parametric evaluation of tumor malignancy. Multi-parametric MRI sequences at 3 Tesla were evaluated in 10 patients to investigate hypoxia in prostate cancer prior to radical prostatectomy...
August 24, 2017: Diagnostics
https://www.readbyqxmd.com/read/28817080/feasibility-study-of-an-optical-caustic-plasmonic-light-scattering-sensor-for-human-serum-anti-dengue-protein-e-antibody-detection
#7
Antonio A García, Lina S Franco, Miguel A Pirez-Gomez, José L Pech-Pacheco, Jorge F Mendez-Galvan, Carlos Machain-Williams, Lourdes Talavera-Aguilar, José H Espinosa-Carrillo, Miriam M Duarte-Villaseñor, Christian Be-Ortiz, Luz E Espinosa-de Los Monteros, Ariel Castillo-Pacheco, Julian E Garcina-Rejon
Antibody detection and accurate diagnosis of tropical diseases is essential to help prevent the spread of disease. However, most detection methods lack cost-effectiveness and field portability, which are essential features for achieving diagnosis in a timely manner. To address this, 3D-printed oblate spheroid sample chambers were fabricated to measure green light scattering of gold nanoparticles using an optical caustic focus to detect antibodies. Scattering signals of 20-200 nm gold nanoparticles using a green laser were compared to green light emitting diode (LED) light source signals and to Mie theory...
August 17, 2017: Diagnostics
https://www.readbyqxmd.com/read/28788065/pectoralis-minor-syndrome-subclavicular-brachial-plexus-compression
#8
REVIEW
Richard J Sanders, Stephen J Annest
The diagnosis of brachial plexus compression-either neurogenic thoracic outlet syndrome (NTOS) or neurogenic pectoralis minor syndrome (NPMS)-is based on old fashioned history and physical examination. Tests, such as scalene muscle and pectoralis minor muscle blocks are employed to confirm a diagnosis suspected on clinical findings. Electrodiagnostic studies can confirm a diagnosis of nerve compression, but cannot establish it. This is not a diagnosis of exclusion; the differential and associated diagnoses of upper extremity pain are always considered...
July 28, 2017: Diagnostics
https://www.readbyqxmd.com/read/28753985/new-biomarkers-and-diagnostic-tools-for-the-management-of-fever-in-low-and-middle-income-countries-an-overview-of-the-challenges
#9
REVIEW
Camille Escadafal, Christian Nsanzabana, Julie Archer, Violet Chihota, William Rodriguez, Sabine Dittrich
A lack of simple, inexpensive, and rapid diagnostic tests for febrile illnesses other than malaria leads to overtreatment with antibiotics for those who test negative for malaria, and contributes to the global rise in antimicrobial resistance. New tests for the detection of host biomarkers provide promising tools to differentiate bacterial from non-bacterial infections in febrile patients. However, most available biomarker tests are not currently used in resource-limited settings, and very few evaluations have been performed in low- and middle-income country populations with non-severe febrile illness...
July 21, 2017: Diagnostics
https://www.readbyqxmd.com/read/28726731/the-use-of-imaging-in-the-prediction-and-assessment-of-cancer-treatment-toxicity
#10
REVIEW
Hossein Jadvar
Multimodal imaging is commonly used in the management of patients with cancer. Imaging plays pivotal roles in the diagnosis, initial staging, treatment response assessment, restaging after treatment and the prognosis of many cancers. Indeed, it is difficult to imagine modern precision cancer care without the use of multimodal molecular imaging, which is advancing at a rapid pace with innovative developments in imaging sciences and an improved understanding of the complex biology of cancer. Cancer therapy often leads to undesirable toxicity, which can range from an asymptomatic subclinical state to severe end organ damage and even death...
July 20, 2017: Diagnostics
https://www.readbyqxmd.com/read/28698484/dual-energy-x-ray-absorptiometry-of-both-hips-helps-appropriate-diagnosis-of-low-bone-mineral-density-and-osteoporosis
#11
Pia Afzelius, Mette-Marie Garding, Stig Molsted
Controversy still remains regarding the use of bilateral hip scanning when bone mineral density (BMD) is measured, and bilateral hip scanning is not mandatory in international guidelines for screening of osteoporosis. BMD of both hips and the lumbar spine was analyzed in 133 consecutive individuals. There were discrepancies between the lowest T-scores of both hips. Fourteen of the 133 participants (11%) were diagnosed with a poorer BMD status when the BMD of the hip of the dominant leg was analyzed. The total hip BMD of the dominant hip was lower than in the non-dominant hip, (p = 0...
July 9, 2017: Diagnostics
https://www.readbyqxmd.com/read/28677648/advancing-point-of-care-poc-testing-using-human-saliva-as-liquid-biopsy
#12
REVIEW
Rabia Sannam Khan, Zohaib Khurshid, Faris Yahya Ibrahim Asiri
Salivary diagnostics is an emerging field for the encroachment of point of care technology (PoCT). The necessity of the development of point-of-care (PoC) technology, the potential of saliva, identification and validation of biomarkers through salivary diagnostic toolboxes, and a broad overview of emerging technologies is discussed in this review. Furthermore, novel advanced techniques incorporated in devices for the early detection and diagnosis of several oral and systemic diseases in a non-invasive, easily-monitored, less time consuming, and in a personalised way is explicated...
July 4, 2017: Diagnostics
https://www.readbyqxmd.com/read/28677632/ultrasonographic-diagnosis-of-thoracic-outlet-syndrome-secondary-to-brachial-plexus-piercing-variation
#13
Vanessa Leonhard, Gregory Caldwell, Mei Goh, Sean Reeder, Heather F Smith
Structural variations of the thoracic outlet create a unique risk for neurogenic thoracic outlet syndrome (nTOS) that is difficult to diagnose clinically. Common anatomical variations in brachial plexus (BP) branching were recently discovered in which portions of the proximal plexus pierce the anterior scalene. This results in possible impingement of BP nerves within the muscle belly and, therefore, predisposition for nTOS. We hypothesized that some cases of disputed nTOS result from these BP branching variants...
July 4, 2017: Diagnostics
https://www.readbyqxmd.com/read/28654016/salivary-immune-and-metabolic-marker-analysis-simma-a-diagnostic-test-to-predict-caries-risk
#14
Alex Mira, Alejandro Artacho, Anny Camelo-Castillo, Sandra Garcia-Esteban, Aurea Simon-Soro
By using ELISA and colorimetric tests, we have measured 25 compounds in individuals with and without dental caries at different time points of dental biofilm formation and time of the day. We find that some compounds appear to be affected by circadian rhythms, others by dental plaque maturity, and others show constant values during a 24 h period. Using univariate analysis and cross-validation techniques, we have selected six components measured at specific time points that maximize the diagnostic separation of health and disease conditions...
June 27, 2017: Diagnostics
https://www.readbyqxmd.com/read/28644402/choosing-surgery-for-neurogenic-tos-the-roles-of-physical-exam-physical-therapy-and-imaging
#15
REVIEW
David P Kuwayama, Jason R Lund, Charles O Brantigan, Natalia O Glebova
Neurogenic thoracic outlet syndrome (nTOS) is characterized by arm and hand pain, paresthesias, and sometimes weakness resulting from compression of the brachial plexus within the thoracic outlet. While it is the most common subtype of TOS, nTOS can be difficult to diagnose. Furthermore, patient selection for surgical treatment can be challenging as symptoms may be vague and ambiguous, and diagnostic studies may be equivocal. Herein, we describe some approaches to aid in identifying patients who would be expected to benefit from surgical intervention for nTOS...
June 23, 2017: Diagnostics
https://www.readbyqxmd.com/read/28629121/creating-a-registry-for-patients-with-thoracic-outlet-syndrome
#16
Misty D Humphries
The creation of any patient database requires substantial planning. In the case of thoracic outlet syndrome, which is a rare disease, the Society for Vascular Surgery has defined reporting standards to serve as an outline for the creation of a patient registry. Prior to undertaking this task, it is critical that designers understand the basics of registry planning and a priori establish plans for data collection and analysis.
June 17, 2017: Diagnostics
https://www.readbyqxmd.com/read/28604623/dynamic-contrast-enhanced-ultrasound-of-colorectal-liver-metastases-as-an-imaging-modality-for-early-response-prediction-to-chemotherapy
#17
Marie Benzon Mogensen, Martin Lundsgaard Hansen, Birthe Merete Henriksen, Thomas Axelsen, Ben Vainer, Kell Osterlind, Michael Bachmann Nielsen
Our aim was to investigate whether dynamic contrast-enhanced ultrasound (DCE-US) can detect early changes in perfusion of colorectal liver metastases after initiation of chemotherapy. Newly diagnosed patients with colorectal cancer with liver metastases were enrolled in this explorative prospective study. Patients were treated with capecitabine or 5-fluorouracil-based chemotherapy with or without bevacizumab. DCE-US was performed before therapy (baseline) and again 10 days after initiation of treatment. Change in contrast-enhancement in one liver metastasis (indicator lesion) was measured...
June 12, 2017: Diagnostics
https://www.readbyqxmd.com/read/28604581/vascular-tos-creating-a-protocol-and-sticking-to-it
#18
REVIEW
Meena Archie, David Rigberg
Thoracic Outlet Syndrome (TOS) describes a set of disorders that arise from compression of the neurovascular structures that exit the thorax and enter the upper extremity. This can present as one of three subtypes: neurogenic, venous, or arterial. The objective of this section is to outline our current practice at a single, high-volume institution for venous and arterial TOS. VTOS: Patients who present within two weeks of acute deep vein thrombosis (DVT) are treated with anticoagulation, venography, and thrombolysis...
June 10, 2017: Diagnostics
https://www.readbyqxmd.com/read/28590428/building-relations-with-radiology-administrators
#19
Megan Kalambo, Jay R Parikh
In some radiology departments, the lack of alignment between administrators and radiologists can pose significant challenges. This article describes how differences in background and priorities between administrators and radiologists can contribute to conflict and presents strategies on how to manage the conflict in a way that can leverage positive change. Strategies to build relations between radiologists and radiology administrators are described.
June 7, 2017: Diagnostics
https://www.readbyqxmd.com/read/28574444/validation-of-the-performance-of-international-ovarian-tumor-analysis-iota-methods-in-the-diagnosis-of-early-stage-ovarian-cancer-in-a-non-screening-population
#20
Wouter Froyman, Laure Wynants, Chiara Landolfo, Tom Bourne, Lil Valentin, Antonia Testa, Povilas Sladkevicius, Dorella Franchi, Daniela Fischerova, Luca Savelli, Ben Van Calster, Dirk Timmerman
BACKGROUND: The aim of this study was to assess and compare the performance of different ultrasound-based International Ovarian Tumor Analysis (IOTA) strategies and subjective assessment for the diagnosis of early stage ovarian malignancy. METHODS: This is a secondary analysis of a prospective multicenter cross-sectional diagnostic accuracy study that included 1653 patients recruited at 18 centers from 2009 to 2012. All patients underwent standardized transvaginal ultrasonography by experienced ultrasound investigators...
June 2, 2017: Diagnostics
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