journal
MENU ▼
Read by QxMD icon Read
search

NPJ Schizophrenia

journal
https://www.readbyqxmd.com/read/29950691/the-role-of-panss-symptoms-and-adverse-events-in-explaining-the-effects-of-paliperidone-on-social-functioning-a-causal-mediation-analysis-approach
#1
Xue Zou, Yiwen Zhu, John W Jackson, Andrea Bellavia, Garrett M Fitzmaurice, Franca Centorrino, Linda Valeri
To date, no study has evaluated the joint role of symptoms and adverse events as mediators of the effect of second-generation antipsychotics on patients' social functioning. We used recently developed methods for mediation analysis with multiple mediators to clarify the interplay of adverse events and symptoms in explaining the effects of paliperidone (R code for implementing the mediation analysis for multiple mediators is provided). We used data from 490 participants in a 6-week randomized dose-response trial that assigned three fixed dosages of ER OROS paliperidone (3, 9, and 15 mg/day)...
June 27, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29950586/risk-of-weight-gain-for-specific-antipsychotic-drugs-a-meta-analysis
#2
Jacob Spertus, Marcela Horvitz-Lennon, Haley Abing, Sharon-Lise Normand
People with schizophrenia are at considerably higher risk of cardiometabolic morbidity than the general population. Second-generation antipsychotic drugs contribute to that risk partly through their weight gain effects, exacerbating an already high burden of disease. While standard 'as-randomized' analyses of clinical trials provide valuable information, they ignore adherence patterns across treatment arms, confounding estimates of realized treatment exposure on outcome. We assess the effect of specific second-generation antipsychotics on weight gain, defined as at least a 7% increase in weight from randomization, using a Bayesian hierarchical model network meta-analysis with individual patient level data...
June 27, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29950580/the-open-translational-science-in-schizophrenia-optics-project-an-open-science-project-bringing-together-janssen-clinical-trial-and-nimh-data
#3
REVIEW
Marsha A Wilcox, Adam J Savitz, Anjené M Addington, Gary S Gray, Eva C Guinan, John W Jackson, Thomas Lehner, Sharon-Lise Normand, Hardeep Ranu, Geetha Senthil, Jake Spertus, Linda Valeri, Joseph S Ross
Clinical trial data are the gold standard for evaluating pharmaceutical safety and efficacy. There is an ethical and scientific imperative for transparency and data sharing to confirm published results and generate new knowledge. The Open Translational Science in Schizophrenia (OPTICS) Project was an open-science initiative aggregating Janssen clinical trial and NIH/NIMH data from real-world studies and trials in schizophrenia. The project aims were to show the value of using shared data to examine: therapeutic safety and efficacy; disease etiologies and course; and methods development...
June 27, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29941938/neurapro-a-multi-centre-rct-of-omega-3-polyunsaturated-fatty-acids-versus-placebo-in-young-people-at-ultra-high-risk-of-psychotic-disorders-medium-term-follow-up-and-clinical-course
#4
B Nelson, G P Amminger, H P Yuen, C Markulev, S Lavoie, M R Schäfer, J A Hartmann, N Mossaheb, M Schlögelhofer, S Smesny, I B Hickie, G Berger, E Y H Chen, L de Haan, D H Nieman, M Nordentoft, A Riecher-Rössler, S Verma, A Thompson, A R Yung, P D McGorry
This study reports a medium-term follow-up of a randomised, double-blind, placebo-controlled trial of omega-3 polyunsaturated fatty acids (PUFA) in ultra-high risk for psychosis (UHR) patients. Primary outcomes of interest were transition to psychosis and symptomatic and functional outcome. A secondary aim was to investigate clinical predictors of medium-term outcome. Three hundred four UHR participants were recruited across 10 specialised early psychosis services in Australia, Asia, and Europe. The intervention consisted of 1...
June 25, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29925851/trajectories-and-changes-in-individual-items-of-positive-and-negative-syndrome-scale-among-schizophrenia-patients-prior-to-impending-relapse
#5
Dai Wang, Srihari Gopal, Susan Baker, Vaibhav A Narayan
Effective early detection of impending relapse may offer opportunities for early interventions to prevent full relapse in schizophrenia patients. Previously reported early warning signs were not consistently validated by prospective studies. It remains unclear which symptoms are most predictive of relapse. To prioritize the symptoms to be captured by periodic self-report in technology-enabled remote assessment solutions for monitoring symptoms and detecting relapse early, we analyzed data from three relapse-prevention studies to identify individual items of the Positive and Negative Syndrome Scale (PANSS) that changed the most prior to relapse and to understand exactly when these symptoms manifested...
June 20, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29808011/impairment-in-delay-discounting-in-schizophrenia-and-schizoaffective-disorder-but-not-primary-mood-disorders
#6
Hannah E Brown, Kamber L Hart, Leslie A Snapper, Joshua L Roffman, Roy H Perlis
A measure of planning and impulse control, the delay-discounting (DD) task estimates the extent to which an individual decreases the perceived value of a reward as the reward is delayed. We examined cross-disorder performance between healthy controls (n = 88), individuals with bipolar disorder (n = 23), major depressive disorder (n = 43), and primary psychotic disorders (schizophrenia and schizoaffective disorder; n = 51) on the DD task (using a $10 delayed larger reward), as well as the interaction of DD scores with other symptom domains (cognition, psychosis, and affect)...
May 28, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29736018/evaluation-of-fronto-striatal-networks-during-cognitive-control-in-unmedicated-patients-with-schizophrenia-and-the-effect-of-antipsychotic-medication
#7
Elyse J Cadena, David M White, Nina V Kraguljac, Meredith A Reid, Adrienne C Lahti
To understand the mechanism of cognitive control dysfunction in schizophrenia, it is critical to characterize brain function without the confounding effect of medication. It is also important to establish the extent to which antipsychotic medication restores brain function and whether those changes are related to psychosis improvement. Twenty-two patients with schizophrenia, initially unmedicated and after a 6-week course of risperidone, and 20 healthy controls (HC) studied twice, 6 weeks apart, performed an fMRI task...
May 7, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29654278/identification-of-somatic-mutations-in-monozygotic-twins-discordant-for-psychiatric-disorders
#8
Masaki Nishioka, Miki Bundo, Junko Ueda, Akane Yoshikawa, Fumichika Nishimura, Tsukasa Sasaki, Chihiro Kakiuchi, Kiyoto Kasai, Tadafumi Kato, Kazuya Iwamoto
Monozygotic twins are assumed to have identical genomes. Based on this assumption, phenotypic discordance in monozygotic twins has been previously attributed to environmental factors. However, recent genomic studies have identified characteristic somatic mutations in monozygotic twins discordant for Darier disease, Van der Woude syndrome, and Dravet syndrome. Here, we explored somatic mutations in four pairs of monozygotic twins discordant for schizophrenia or delusional disorder. We analyzed whole exome sequence data obtained from blood samples and identified seven somatic mutations in one twin pair discordant for delusional disorder...
April 13, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29626190/a-crossroad-for-validating-digital-tools-in-schizophrenia-and-mental-health
#9
EDITORIAL
John Torous, Patrick Staples, Ian Barnett, Jukka-Pekka Onnela, Matcheri Keshavan
No abstract text is available yet for this article.
April 6, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29555928/altered-dna-methylation-associated-with-a-translocation-linked-to-major-mental-illness
#10
Daniel L McCartney, Rosie M Walker, Stewart W Morris, Susan M Anderson, Barbara J Duff, Riccardo E Marioni, J Kirsty Millar, Shane E McCarthy, Niamh M Ryan, Stephen M Lawrie, Andrew R Watson, Douglas H R Blackwood, Pippa A Thomson, Andrew M McIntosh, W Richard McCombie, David J Porteous, Kathryn L Evans
Recent work has highlighted a possible role for altered epigenetic modifications, including differential DNA methylation, in susceptibility to psychiatric illness. Here, we investigate blood-based DNA methylation in a large family where a balanced translocation between chromosomes 1 and 11 shows genome-wide significant linkage to psychiatric illness. Genome-wide DNA methylation was profiled in whole-blood-derived DNA from 41 individuals using the Infinium HumanMethylation450 BeadChip (Illumina Inc., San Diego, CA)...
March 19, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29463818/changed-frontal-pole-gene-expression-suggest-altered-interplay-between-neurotransmitter-developmental-and-inflammatory-pathways-in-schizophrenia
#11
Elizabeth Scarr, Madhara Udawela, Brian Dean
Schizophrenia (Sz) probably occurs after genetically susceptible individuals encounter a deleterious environmental factor that triggers epigenetic mechanisms to change CNS gene expression. To determine if omnibus changes in CNS gene expression are present in Sz, we compared mRNA levels in the frontal pole (Brodmann's area (BA) 10), the dorsolateral prefrontal cortex (BA 9) and cingulate cortex (BA 33) from 15 subjects with Sz and 15 controls using the Affymetrix™ Human Exon 1.0 ST Array. Differences in mRNA levels (±≥20%; p < 0...
February 20, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29449557/differential-patterns-of-contextual-organization-of-memory-in-first-episode-psychosis
#12
Vishnu P Murty, Rachel A McKinney, Sarah DuBrow, Maria Jalbrzikowski, Gretchen L Haas, Beatriz Luna
Contextual information is used to support and organize episodic memory. Prior research has reliably shown memory deficits in psychosis; however, little research has characterized how this population uses contextual information during memory recall. We employed an approach founded in a computational framework of free recall to quantify how individuals with first episode of psychosis (FEP, N = 97) and controls (CON, N = 55) use temporal and semantic context to organize memory recall. Free recall was characterized using the Hopkins Verbal Learning Test-Revised (HVLT-R)...
February 15, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29426848/sleep-endophenotypes-of-schizophrenia-slow-waves-and-sleep-spindles-in-unaffected-first-degree-relatives
#13
Armando D'Agostino, Anna Castelnovo, Simone Cavallotti, Cecilia Casetta, Matteo Marcatili, Orsola Gambini, Mariapaola Canevini, Giulio Tononi, Brady Riedner, Fabio Ferrarelli, Simone Sarasso
Sleep spindles and slow waves are the main brain oscillations occurring in non-REM sleep. Several lines of evidence suggest that spindles are initiated within the thalamus, whereas slow waves are generated and modulated in the cortex. A decrease in sleep spindle activity has been described in Schizophrenia (SCZ), including chronic, early course, and early onset patients. In contrast, slow waves have been inconsistently found to be reduced in SCZ, possibly due to confounds like duration of illness and antipsychotic medication exposure...
February 9, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29321530/the-effect-of-raloxifene-augmentation-in-men-and-women-with-a-schizophrenia-spectrum-disorder-a-systematic-review-and-meta-analysis
#14
REVIEW
Janna de Boer, Merel Prikken, Wan U Lei, Marieke Begemann, Iris Sommer
Recognizing the robust sex differences in schizophrenia prevalence, the selective estrogen receptor modulator (SERM) raloxifene is a likely candidate for augmentation therapy in this disorder. Therefore, a systematic search was performed using PubMed (Medline), Embase, PsychInfo, and Cochrane Database of Systematic Reviews. Randomized controlled trials investigating the effect of raloxifene in schizophrenia spectrum disorders were included in the quantitative analyses. Outcome measures were psychotic symptom severity, depression, and cognition...
January 10, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29138398/characterization-of-macrophages-from-schizophrenia-patients
#15
Paul R Ormel, Hans C van Mierlo, Manja Litjens, Miriam E van Strien, Elly M Hol, René S Kahn, Lot D de Witte
Genetic, epidemiological and post mortem studies have described an association between schizophrenia (SCZ) and the immune system. Microglia, the tissue-resident macrophages of the brain, not only play an essential role in inflammatory processes, but also in neurodevelopment and synapse refinement. It has therefore been hypothesized that aberrant functioning of these myeloid immune cells is involved in SCZ pathogenesis. Until now cellular research into the role of myeloid cells in SCZ has been limited to monocytes and functional assays are lacking...
November 14, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29093492/the-association-between-gene-variants-and-longitudinal-structural-brain-changes-in-psychosis-a-systematic-review-of-longitudinal-neuroimaging-genetics-studies
#16
REVIEW
Julia H Harari, Covadonga M Díaz-Caneja, Joost Janssen, Kenia Martínez, Bárbara Arias, Celso Arango
Evidence suggests that genetic variation might influence structural brain alterations in psychotic disorders. Longitudinal genetic neuroimaging (G-NI) studies are designed to assess the association between genetic variants, disease progression and brain changes. There is a paucity of reviews of longitudinal G-NI studies in psychotic disorders. A systematic search of PubMed from inception until November 2016 was conducted to identify longitudinal G-NI studies examining the link between Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI)-based brain measurements and specific gene variants (SNPs, microsatellites, haplotypes) in patients with psychosis...
November 1, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29079805/genetic-interaction-of-disc1-and-neurexin-in-the-development-of-fruit-fly-glutamatergic-synapses
#17
Himani Pandey, Katia Bourahmoune, Takato Honda, Ken Honjo, Kazuki Kurita, Tomohito Sato, Akira Sawa, Katsuo Furukubo-Tokunaga
Originally identified at the breakpoint of a (1;11)(q42.1; q14.3) chromosomal translocation in a Scottish family with a wide range of mental disorders, the DISC1 gene has been a focus of intensive investigations as an entry point to study the molecular mechanisms of diverse mental dysfunctions. Perturbations of the DISC1 functions lead to behavioral changes in animal models, which are relevant to psychiatric conditions in patients. In this work, we have expressed the human DISC1 gene in the fruit fly (Drosophila melanogaster) and performed a genetic screening for the mutations of psychiatric risk genes that cause modifications of DISC1 synaptic phenotypes at the neuromuscular junction...
October 27, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29062020/correspondence-regarding-two-recent-publications-in-npj-schizophrenia-about-dnam-and-accelerated-aging-in-schizophrenia
#18
LETTER
Emilio Fernandez-Egea, Brian Kirkpatrick
No abstract text is available yet for this article.
October 23, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29038553/a-comparison-of-passive-and-active-estimates-of-sleep-in-a-cohort-with-schizophrenia
#19
Patrick Staples, John Torous, Ian Barnett, Kenzie Carlson, Luis Sandoval, Matcheri Keshavan, Jukka-Pekka Onnela
Sleep abnormalities are considered an important feature of schizophrenia, yet convenient and reliable sleep monitoring remains a challenge. Smartphones offer a novel solution to capture both self-reported and objective measures of sleep in schizophrenia. In this three-month observational study, 17 subjects with a diagnosis of schizophrenia currently in treatment downloaded Beiwe, a platform for digital phenotyping, on their personal Apple or Android smartphones. Subjects were given tri-weekly ecological momentary assessments (EMAs) on their own smartphones, and passive data including accelerometer, GPS, screen use, and anonymized call and text message logs was continuously collected...
October 16, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29021565/psychosis-breakthrough-on-antipsychotic-maintenance-medication-bamm-what-can-we-learn
#20
EDITORIAL
Jose M Rubio, John M Kane
No abstract text is available yet for this article.
October 11, 2017: NPJ Schizophrenia
journal
journal
50168
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"