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JACC. Clinical Electrophysiology

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https://www.readbyqxmd.com/read/28770255/massive-accumulation-of-myofibroblasts-in%C3%A2-the-critical-isthmus-is-associated-with%C3%A2-ventricular-tachycardia-inducibility-in%C3%A2-post-infarct-swine-heart
#1
Tarvinder S Dhanjal, Nicolas Lellouche, Christopher J von Ruhland, Guillaume Abehsira, David H Edwards, Jean-Luc Dubois-Randé, Konstantinos Moschonas, Emmanuel Teiger, Alan J Williams, Christopher H George
OBJECTIVES: In this study the authors determined the extent of cellular infiltration and dispersion, and regional vascularization in electrophysiologically (EP) defined zones in post-myocardial infarction (MI) swine ventricle. BACKGROUND: The critical isthmus (CI) in post-MI re-entrant ventricular tachycardia (VT) is a target for catheter ablation. In vitro evidence suggests that myofibroblasts (MFB) within the scar border zone (BZ) may increase the susceptibility to slow conduction and VT, but whether this occurs in vivo remains unproven...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28736750/a-novel-defibrillation-tool-percutaneously-delivered-partially-insulated-epicardial-defibrillation
#2
Ammar M Killu, Niyada Naksuk, Zdeněk Stárek, Christopher V DeSimone, Faisal F Syed, Prakriti Gaba, Jiří Wolf, Frantisek Lehar, Martin Pesl, Pavel Leinveber, Michal Crha, Dorothy Ladewig, Joanne Powers, Scott Suddendorf, David O Hodge, Gaurav Satam, Miroslav Novák, Tomas Kara, Charles J Bruce, Paul A Friedman, Samuel J Asirvatham
INTRODUCTION: Epicardial defibrillation systems currently require surgical access. We aimed to develop a percutaneous defibrillation system with partially-insulated epicardial coils to focus electrical energy on the myocardium and prevent or minimize extra-cardiac stimulation. METHODS: We tested 2 prototypes created for percutaneous introduction into the pericardial space via a steerable sheath. This included a partially-insulated defibrillation coil and a defibrillation mesh with a urethane balloon acting as an insulator to the face of the mesh not in contact with the epicardium...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28804785/periprocedural-antibiotic-prophylaxis-for-cardiac-implantable-electrical-device-procedures-results-from-a-heart-rhythm-society-survey
#3
Anuj Basil, Steven A Lubitz, Peter A Noseworthy, Matthew R Reynolds, Howard Gold, David Yassa, Daniel Kramer
No abstract text is available yet for this article.
June 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28534047/polysomnographic-heart-rate-variability-indices-and-atrial-ectopy-associated-with-incident-atrial-fibrillation-risk-in-older-community-dwelling-men
#4
Dileep Raman, Farhad Kaffashi, Li-Yung Lui, William H Sauer, Susan Redline, Peter Stone, Peggy M Cawthon, Katie L Stone, Kristine E Ensrud, Sonia Ancoli-Israel, Kenneth Loparo, Reena Mehra
BACKGROUND: Autonomic dysfunction contributes to atrial fibrillation (AF). OBJECTIVE: We hypothesized that polysomnogram (PSG)-based heart rate variability (HRV) autonomic function biomarkers are associated with incident AF and these associations are modified by measures of sleep disordered breathing (SDB). METHODS: 2350 participants of a multi-center prospective study (Outcomes of Sleep Disorders in Older Men Study) without baseline AF underwent sleep studies with incident adjudicated AF follow up (8...
May 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28596994/recurrent-post-ablation-paroxysmal-atrial-fibrillation-shares-substrates-with-persistent-atrial-fibrillation-an-11-center-study
#5
Junaid A B Zaman, Tina Baykaner, Paul Clopton, Vijay Swarup, Robert C Kowal, James P Daubert, John D Day, John Hummel, Amir A Schricker, David E Krummen, Moussa Mansour, Gery F Tomassoni, Kevin R Wheelan, Mohan Vishwanathan, Shirley Park, Paul J Wang, Sanjiv M Narayan, John M Miller
INTRODUCTION: The role of atrial fibrillation (AF) substrates is unclear in patients with paroxysmal AF (PAF) that recurs after pulmonary vein isolation (PVI). We hypothesized that patients with recurrent post-ablation (redo) PAF despite PVI have electrical substrates marked by rotors and focal sources, and structural substrates that resemble persistent AF more than patients with (de novo) PAF at first ablation. METHODS: In 175 patients at 11 centers, we compared AF substrates in both atria using 64 pole-basket catheters and phase mapping, and indices of anatomical remodeling between patients with de novo or redo PAF and first ablation for persistent AF...
April 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28553663/does-the-implantable-cardioverter-defibrillator-benefit-vary-with-the-estimated-proportional-risk-of-sudden-death-in-heart-failure-patients
#6
Wayne C Levy, Yanhong Li, Shelby D Reed, Michael R Zile, Ramin Shadman, Todd Dardas, David J Whellan, Kevin A Schulman, Stephen J Ellis, Matthew Neilson, Christopher M O'Connor
BACKGROUND: Prediction of which heart failure patients are most likely to die of sudden death vs. non-sudden death is an important factor in determining who will benefit the most from an ICD. OBJECTIVE: We developed the Seattle Proportional Risk Model (SPRM) to estimate the proportion of total mortality due to sudden death. We prospectively validated the model in HF-ACTION and tested whether the ICD benefit varied with the SPRM. METHODS: Among 2331 patients enrolled, 1947 patients were retained for analysis over a median follow-up of 2...
March 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28280785/cost-effectiveness-analysis-of-quadripolar%C3%A2-versus-bipolar-left-ventricular-leads-for-cardiac-resynchronization-defibrillator-therapy%C3%A2-in%C3%A2-a-large-multicenter-uk%C3%A2-registry
#7
Jonathan M Behar, Hui Men Selina Chin, Steve Fearn, Julian O M Ormerod, James Gamble, Paul W X Foley, Julian Bostock, Simon Claridge, Tom Jackson, Manav Sohal, Antonios P Antoniadis, Reza Razavi, Tim R Betts, Neil Herring, Christopher Aldo Rinaldi
OBJECTIVES: The objective of this study was to evaluate the cost-effectiveness of quadripolar versus bipolar cardiac resynchronization defibrillator therapy systems. BACKGROUND: Quadripolar left ventricular (LV) leads for cardiac resynchronization therapy reduce phrenic nerve stimulation (PNS) and are associated with reduced mortality compared with bipolar leads. METHODS: A total of 606 patients received implants at 3 UK centers (319 Q, 287 B), between 2009 and 2014; mean follow-up was 879 days...
February 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28451647/influence-of-oral-progesterone-administration-on-drug-induced-qt-interval-lengthening-a-randomized-double-blind-placebo-controlled-crossover-study
#8
James E Tisdale, Heather A Jaynes, Brian R Overholser, Kevin M Sowinski, David A Flockhart, Richard J Kovacs
OBJECTIVES: We tested the hypothesis that oral progesterone administration attenuates drug-induced QT interval lengthening. BACKGROUND: Evidence from preclinical and human investigations suggests that higher serum progesterone concentrations may be protective against drug-induced QT interval lengthening. METHODS: In this prospective, double-blind, crossover study, 19 healthy female volunteers (21-40 years) were randomized to receive progesterone 400 mg or matching placebo orally once daily for 7 days timed to the menses phase of the menstrual cycle (between-phase washout period = 49 days)...
December 2016: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28066827/optimized-left-ventricular-endocardial-stimulation%C3%A2-is-superior-to-optimized-epicardial%C3%A2-stimulation-in-ischemic-patients-with%C3%A2-poor-response-to-cardiac-resynchronization%C3%A2-therapy-a%C3%A2-combined-magnetic-resonance-imaging-electroanatomic%C3%A2-contact-mapping-and-hemodynamic
#9
Jonathan M Behar, Tom Jackson, Eoin Hyde, Simon Claridge, Jaswinder Gill, Julian Bostock, Manav Sohal, Bradley Porter, Mark O'Neill, Reza Razavi, Steve Niederer, Christopher Aldo Rinaldi
OBJECTIVES: The purpose of this study was to identify the optimal pacing site for the left ventricular (LV) lead in ischemic patients with poor response to cardiac resynchronization therapy (CRT). BACKGROUND: LV endocardial pacing may offer benefit over conventional CRT in ischemic patients. METHODS: We performed cardiac magnetic resonance, invasive electroanatomic mapping (EAM), and measured the acute hemodynamic response (AHR) in patients with existing CRT systems...
December 2016: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28451646/chronotropic-incompetence-and-risk-of-atrial-fibrillation-the-henry-ford-exercise-testing-fit-project
#10
Wesley T O'Neal, Waqas T Qureshi, Michael J Blaha, Zeina A Dardari, Jonathan K Ehrman, Clinton A Brawner, Elsayed Z Soliman, Mouaz H Al-Mallah
OBJECTIVES: To examine the association between chronotropic incompetence and incident atrial fibrillation (AF). BACKGROUND: Patients with inadequate heart rate response during exercise may have abnormalities in sinus node function or autonomic tone that predispose to the development of AF. METHODS: We examined the association between heart rate response and incident AF in 57,402 (mean age=54±13 years, 47% female, 64% white) patients free of baseline AF who underwent exercise-treadmill stress testing from the Henry Ford ExercIse Testing (FIT) Project...
November 2016: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/27807593/enhancement-of-gap-junction-function-during-acute-myocardial-infarction-modifies-healing-and-reduces-late-ventricular-arrhythmia-susceptibility
#11
Fu Siong Ng, Jeremy M Kalindjian, Simon A Cooper, Rasheda A Chowdhury, Pravina M Patel, Emmanuel Dupont, Alexander R Lyon, Nicholas S Peters
OBJECTIVES: The purpose of this study was to investigate the effects of enhancing gap junction (GJ) coupling during acute myocardial infarction (MI) on the healed infarct scar morphology and late post-MI arrhythmia susceptibility. BACKGROUND: Increased heterogeneity of myocardial scarring after MI is associated with greater arrhythmia susceptibility. We hypothesized that short-term enhancement of GJ coupling during acute MI can produce more homogeneous infarct scars, reducing late susceptibility to post-MI arrhythmias...
October 2016: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/27790640/risk-stratification-in-arrhythmic-right-ventricular-cardiomyopathy-without-implantable-cardioverter-defibrillators
#12
Francesca Brun, Judith A Groeneweg, Kathleen Gear, Gianfranco Sinagra, Jeroen van der Heijden, Luisa Mestroni, Richard N Hauer, Mark Borgstrom, Frank I Marcus, Trina Hughes
OBJECTIVES: The primary objective of this study is risk stratification of patients with arrhythmic right ventricular cardiomyopathy (ARVC). BACKGROUND: There is a need to identify those who need an automatic implantable defibrillator (ICD) to prevent sudden death. METHODS: This is an analysis of 88 patients with ARVC from three centers who were not treated with an ICD. RESULTS: Risk factors for subsequent arrhythmic deaths were pre-enrollment sustained or nonsustained ventricular tachycardia (VT) and decreased left ventricular function...
October 2016: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/27725967/non-invasive-neuromodulation-via-tragal-stimulation-time-to-lend-an-ear
#13
Olujimi A Ajijola, David Hamon
No abstract text is available yet for this article.
June 2016: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/27042693/structural-and-functional-bases-of-cardiac-fibrillation-differences-and-similarities-between-atria-and-ventricles
#14
David Filgueiras-Rama, José Jalife
Evidence accumulated over the last 25 years suggests that, whether in the atria or ventricles, fibrillation may be explained by the self-organization of the cardiac electrical activity into rapidly spinning rotors giving way to spiral waves that break intermittently and result in fibrillatory conduction. The dynamics and frequency of such rotors depend on the ion channel composition, excitability and refractory properties of the tissues involved, as well as on the thickness and respective three-dimensional fiber structure of the atrial and ventricular chambers...
February 1, 2016: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/26949741/electrocardiographic-markers-and-the-left-ventricular-ejection-fraction-have-cumulative-effects-on-risk-of-sudden-cardiac-death
#15
Kyndaron Reinier, Kumar Narayanan, Audrey Uy-Evanado, Carmen Teodorescu, Harpriya Chugh, Wendy J Mack, Karen Gunson, Jonathan Jui, Sumeet S Chugh
OBJECTIVES: To assess potential improvement in SCD risk prediction by adding selected risk markers from the 12-lead ECG to measurement of the left ventricular ejection fraction (LVEF). BACKGROUND: Novel strategies to improve risk stratification for sudden cardiac death (SCD) are needed. Given the modest odds associated with most individual risk markers, combining multiple markers may be a useful approach. METHODS: From the ongoing Oregon Sudden Unexpected Death Study, SCD cases with pre-event LVEF available were compared to matched control subjects with coronary artery disease...
December 1, 2015: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/26824079/adiposity-throughout-adulthood-and-risk-of-sudden-cardiac-death-in-women
#16
Stephanie E Chiuve, Qi Sun, Roopinder K Sandhu, Usha Tedrow, Nancy R Cook, JoAnn E Manson, Christine M Albert
BACKGROUND: Sudden cardiac death (SCD) is often the first manifestation of coronary heart disease (CHD) among women. Data regarding BMI and risk of SCD are limited and conflicting. OBJECTIVES: We examined the association of BMI repeatedly measured over 32 years and BMI during early and mid-adulthood with risk of SCD in the Nurses' Health Study. METHODS: We prospectively followed 72,484 women free of chronic disease from 1980-2012. We ascertained adult height, current weight, and weight at age 18 at baseline and updated weight biennially...
December 1, 2015: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/26618198/intentional-right-atrial-exit-and-carbon-dioxide-insufflation-to-facilitate-subxiphoid-needle-entry-into-the-empty-pericardial-space-first-human-experience
#17
Adam B Greenbaum, Toby Rogers, Gaetano Paone, Shawn E Flynn, Mayra E Guerrero, William W O'Neill, Robert J Lederman
OBJECTIVES: The purpose of this study was to test whether a microcatheter can safely be advanced across the right atrial appendage to access the pericardium and then withdrawn despite subsequent high-intensity anticoagulation. We also tested whether transatrial pericardial insufflation of carbon dioxide (CO2) would enhance the safety of subxiphoid needle access to the empty pericardium by separating the heart from the anterior pericardium. BACKGROUND: Subxiphoid needle access to the empty pericardium, required for left atrial suture ligation and epicardial ablation for rhythm disorders, risks myocardial or coronary laceration...
October 2015: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/27547832/percutaneous-epicardial-pacing-using-a-novel-insulated-multi-electrode-lead
#18
Faisal F Syed, Christopher V DeSimone, Elisa Ebrille, Prakriti Gaba, Dorothy J Ladewig, Susan B Mikell, Scott H Suddendorf, Emily J Gilles, Andrew J Danielsen, Markéta Lukášová, Jiří Wolf, Pavel Leinveber, Miroslav Novák, Zdeněk Stárek, Tomas Kara, Charles J Bruce, Paul A Friedman, Samuel J Asirvatham
INTRODUCTION: Epicardial cardiac resynchronization therapy (CRT) permits unrestricted electrode positioning. However, this requires surgical placement of device leads and the risk of unwanted phrenic nerve stimulation. We hypothesized that shielded electrodes can capture myocardium without extracardiac stimulation. METHODS: In 6 dog and 5 swine experiments, we used a percutaneous approach to access the epicardial surface of the heart, and deploy novel leads housing multiple electrodes with selective insulation...
August 2015: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/26557726/incidence-risk-factors-prognosis-and-electrophysiological-mechanisms-of-atrial-arrhythmias-after-lung-transplantation
#19
Kongkiat Chaikriangkrai, Soma Jyothula, Hye Yeon Jhun, Su Min Chang, Edward A Graviss, Mossaab Shuraih, Tapan G Rami, Amish S Dave, Miguel Valderrábano
OBJECTIVE: To investigate incidence and timing, risk factors, prognostic significance, and electrophysiological mechanisms of atrial arrhythmia (AA) after lung transplantation. BACKGROUND: Although new-onset AA is common after thoracic surgery and is associated with poorer outcomes, prognostic and mechanistic data is sparse in lung transplant populations. METHOD: A total of 293 consecutive isolated lung transplant recipients without known AA were retrospectively reviewed...
August 1, 2015: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/26501131/inflammation-as-a-mediator-of-the-association-between-race-and-atrial-fibrillation-results-from-the-health-aging-and-body-composition-study
#20
Thomas A Dewland, Eric Vittinghoff, Tamara B Harris, Jared W Magnani, Yongmei Liu, Fang-Chi Hsu, Suzanne Satterfield, Christina Wassel, Gregory M Marcus
BACKGROUND: Despite a lower prevalence of established atrial fibrillation (AF) risk factors, Whites exhibit substantially higher rates of this arrhythmia compared to Blacks. The mechanism underlying this observation is not known. Both inflammation and obesity are risk factors for AF, and adipose tissue is a known contributor to systemic inflammation. OBJECTIVES: We sought to determine the degree to which racial differences in AF risk are explained by differences in inflammation and adiposity...
August 2015: JACC. Clinical Electrophysiology
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