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JACC. Clinical Electrophysiology

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https://www.readbyqxmd.com/read/30139501/regression-of-diffuse-ventricular-fibrosis-following-restoration-of-sinus-rhythm-with-catheter-ablation-in-patients-with-atrial-fibrillation-and-systolic-dysfunction-a-substudy-of-the-camera-mri-trial
#1
Sandeep Prabhu, Ben T Costello, Andrew J Taylor, Sarah J Gutman, Aleksandr Voskoboinik, Alex J A McLellan, Kah Y Peck, Hariharan Sugumar, Leah Iles, Bhupesh Pathik, Chrishan J Nalliah, Geoff R Wong, Sonia M Azzopardi, Geoffrey Lee, Justin Mariani, David M Kaye, Liang-Han Ling, Jonathan M Kalman, Peter M Kistler
OBJECTIVES: This study sought to determine if diffuse ventricular fibrosis improves in patients with atrial fibrillation (AF)-mediated cardiomyopathy following the restoration of sinus rhythm. BACKGROUND: AF coexists in 30% of heart failure (HF) patients and may be an underrecognized reversible cause of left ventricular systolic dysfunction. Myocardial fibrosis is the hallmark of adverse cardiac remodeling in HF, yet its reversibility is unclear. METHODS: Patients with persistent AF and an idiopathic cardiomyopathy (left ventricular ejection fraction [LVEF] ≤45%) were randomized to catheter ablation (CA) or ongoing medical rate control as a pre-specified substudy of the CAMERA-MRI (Catheter Ablation versus Medical Rate Control in Atrial Fibrillation and Systolic Dysfunction-an MRI-Guided Multi-centre Randomised Controlled Trial) trial...
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139500/catheter-ablation-of-atrial-fibrillation-using-electroporation-back-to-the-future
#2
EDITORIAL
Edward P Gerstenfeld
No abstract text is available yet for this article.
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139499/ablation-of-atrial-fibrillation-with-pulsed-electric-fields-an-ultra-rapid-tissue-selective-modality-for-cardiac-ablation
#3
Vivek Y Reddy, Jacob Koruth, Pierre Jais, Jan Petru, Ferdinand Timko, Ivo Skalsky, Robert Hebeler, Louis Labrousse, Laurent Barandon, Stepan Kralovec, Moritoshi Funosako, Boochi Babu Mannuva, Lucie Sediva, Petr Neuzil
OBJECTIVES: The authors report the first acute clinical experience of atrial fibrillation ablation with PEF-both epicardial box lesions during cardiac surgery, and catheter-based PV isolation. BACKGROUND: Standard energy sources rely on time-dependent conductive heating/cooling and ablate all tissue types indiscriminately. Pulsed electric field (PEF) energy ablates nonthermally by creating nanoscale pores in cell membranes. Potential advantages for atrial fibrillation ablation include: 1) cardiomyocytes have among the lowest sensitivity of any tissue to PEF-allowing tissue selectivity, thereby minimizing ablation of nontarget collateral tissue; 2) PEF is delivered rapidly over a few seconds; and 3) the absence of coagulative necrosis obviates the risk of pulmonary vein (PV) stenosis...
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139498/electroporation-and-its-relevance-for-cardiac-catheter-ablation
#4
REVIEW
Fred H M Wittkampf, René van Es, Kars Neven
Irreversible electroporation can be used as a nonthermal energy source to ablate tissue. Cardiac catheter ablation by irreversible electroporation may be a safe and effective alternative for thermal ablation techniques such as radiofrequency or cryoablation. Total applied current, not delivered power (watts), energy (joules), or voltage, is the parameter that most directly relates to the local voltage gradient that causes electroporation. Electroporation can be achieved with various modalities: direct current, alternating current, pulsed direct current, or any combination of these...
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139497/correction
#5
(no author information available yet)
No abstract text is available yet for this article.
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139496/further-evidence-of-tricuspid-isthmus-muscle-bundles-using-rhythmia-mapping-technology
#6
Charlene Pius, Maille Baptiste, Dhiraj Gupta, Simon Modi
No abstract text is available yet for this article.
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139495/idiopathic-giant-thrombus-formation-in-the-right-ventricular-apex-a-rare-complication-after-radiofrequency-ablation
#7
Kanae Hasegawa, Shinsuke Miyazaki, Kenichi Kaseno, Naoki Amaya, Hiroshi Tada
No abstract text is available yet for this article.
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139494/lateral-percutaneous-epicardial-access-with-a-novel-technique
#8
Ameesh Isath, Anas Abudan Al-Masry, Alan Sugrue, Vaibhav R Vaidya, Deepak Padmanabhan, Paul A Friedman, Samuel J Asirvatham
No abstract text is available yet for this article.
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139493/effects-of-vagal-nerve-stimulation-on-ganglionated-plexi-nerve-activity-and-ventricular-rate-in-ambulatory-dogs-with-persistent-atrial-fibrillation
#9
Zhaolei Jiang, Ye Zhao, Wei-Chung Tsai, Yuan Yuan, Kroekkiat Chinda, Jian Tan, Patrick Onkka, Changyu Shen, Lan S Chen, Michael C Fishbein, Shien-Fong Lin, Peng-Sheng Chen, Thomas H Everett
OBJECTIVES: This study was designed to test the hypothesis that low-level vagal nerve stimulation (VNS) reduces the ventricular rate (VR) during atrial fibrillation (AF) through the activation of the inferior vena cava (IVC)-inferior atrial ganglionated plexus nerve activity (IAGPNA). BACKGROUND: Increased IVC-IAGPNA can suppress atrioventricular node conduction and slow VR in canine models of AF. METHODS: Persistent AF was induced in 6 dogs and the IVC-IAGPNA, right vagal nerve activity, left vagal nerve activity, and an electrocardiogram were recorded...
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139492/the-elusiveness-of-titanium-immortality
#10
EDITORIAL
Sumeet S Chugh, Kyndaron Reinier, Carmen Rusinaru, Audrey Uy-Evanado
No abstract text is available yet for this article.
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139491/improving-the-use-of-primary-prevention-implantable-cardioverter-defibrillators-therapy-with-validated-patient-centric-risk-estimates
#11
Wayne C Levy, Anne S Hellkamp, Daniel B Mark, Jeanne E Poole, Ramin Shadman, Todd F Dardas, Jill Anderson, George Johnson, Daniel P Fishbein, Kerry L Lee, David T Linker, Gust H Bardy
OBJECTIVES: The authors previously developed the Seattle Proportional Risk Model (SPRM) in systolic heart failure patients without implantable cardioverter-defibrillators (ICDs)to predict the proportion of deaths that were sudden. They subsequently validated the SPRM in 2 observational ICD data sets. The objectives in the present study were to determine whether this validated model could improve identification of clinically important variations in the expected magnitude of ICD survival benefit by using a pivotal randomized trial of primary prevention ICD therapy...
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139490/early-diagnosis-of-defibrillation-lead-dislodgement
#12
Junaid A B Zaman, Kelvin Chua, Ali A Sovari, Bruce Gunderson, Eli S Gang, Sylvain Ploux, Charles D Swerdlow
OBJECTIVES: This study sought to develop and evaluate an algorithm for early diagnosis of dislodged implantable cardioverter-defibrillator (ICD) leads. BACKGROUND: Dislodged defibrillation leads may sense atrial and ventricular electrograms (EGMs), triggering shocks in the vulnerable period that induce ventricular fibrillation (VF). METHODS: We developed a 2-step algorithm by using experimental lead dislodgements (LDs) at ICD implantation and a control dataset of newly implanted, in situ leads...
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139489/near-field-ultrasound-imaging-during-radiofrequency-catheter-ablation-lessons-for-today-and-hope-for-tomorrow
#13
EDITORIAL
Travis Richardson, Gregory F Michaud
No abstract text is available yet for this article.
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139488/characteristics-of-radiofrequency-catheter-ablation-lesion-formation-in-real-time-in-vivo-using-near-field-ultrasound-imaging
#14
Matthew Wright, Erik Harks, Szabolcs Deladi, Steven Fokkenrood, Rob Brink, Harm Belt, Alexander F Kolen, Darrell Rankin, William Stoffregen, Debra A Cockayne, Joseph Cefalu, David E Haines
OBJECTIVES: Visualizing myocardium with near field ultrasound (NFUS) transducers in the tip of the catheter might provide an image of the evolving pathological lesion during energy delivery. BACKGROUND: Radiofrequency (RF) catheter ablation has been effective in arrhythmia treatment, but no technology has allowed lesion formation to be visualized in real time in vivo. METHODS: RF catheter ablations were performed in vivo with the goal to create transmural atrial lesions and large ventricular lesions...
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139487/maximal-pre-excitation-based-algorithm-for-localization-of-manifest-accessory-pathways-in-adults
#15
Thomas Pambrun, Rim El Bouazzaoui, Nicolas Combes, Stéphane Combes, Pedro Sousa, Mathieu Le Bloa, Grégoire Massoullié, Ghassen Cheniti, Ruairidh Martin, Xavier Pillois, Josselin Duchateau, Frédéric Sacher, Mélèze Hocini, Pierre Jaïs, Nicolas Derval, Agustín Bortone, Serge Boveda, Arnaud Denis, Michel Haïssaguerre, Jean-Paul Albenque
OBJECTIVES: This study evaluated a new algorithm relying on maximal pre-excitation. BACKGROUND: Prior knowledge of accessory pathway (AP) location facilitates an individual ablation strategy. Delta-wave analysis on a 12-lead electrocardiogram is recognized as crucial for predicting ablation site, but can be ambiguous at basal state. METHODS: An algorithm based on maximal pre-excitation, as induced by atrial pacing during an electrophysiological study, was initially developed in 132 patients with a single manifest AP...
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139486/substrate-mapping-for-functionally-defined-ventricular-re-entry
#16
EDITORIAL
Roy M John, Arvindh N Kanagasundram, William G Stevenson
No abstract text is available yet for this article.
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139485/infarct-related-ventricular-tachycardia-redefining-the-electrophysiological-substrate-of-the-isthmus-during-sinus-rhythm
#17
Elad Anter, Andre G Kleber, Markus Rottmann, Eran Leshem, Michael Barkagan, Cory M Tschabrunn, Fernando M Contreras-Valdes, Alfred E Buxton
OBJECTIVES: In this study, the scientific objective was to characterize the electrophysiological substrate of the ventricular tachycardia (VT) isthmus during sinus rhythm. BACKGROUND: The authors have recently described the electrophysiological characteristics of the VT isthmus using a novel in vivo high-resolution mapping technology. METHODS: Sixteen swine with healed infarction were studied using high-resolution mapping technology (Rhythmia, Boston Scientific, Cambridge, Massachusetts) in a closed-chest model...
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139484/mechanical-esophageal-deviation-during-atrial-fibrillation-ablation-i-like-to-move-it-move-it
#18
EDITORIAL
David S Frankel
No abstract text is available yet for this article.
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139483/esophageal-deviation-during-atrial-fibrillation-ablation-clinical-experience-with-a-dedicated-esophageal-balloon-retractor
#19
Rahul Bhardwaj, Aditi Naniwadekar, William Whang, Alexander J Mittnacht, Chandrasekar Palaniswamy, Jacob S Koruth, Kamal Joshi, Aamir Sofi, Marc Miller, Subbarao Choudry, Srinivas R Dukkipati, Vivek Y Reddy
OBJECTIVES: The goal of this study was to determine the safety and feasibility of a novel esophageal balloon retractor (DV8) for MED during PVI. BACKGROUND: The authors previously showed that mechanical esophageal deviation (MED) is feasible using an off-the-shelf metal stylet to allow uninterrupted ablation along the posterior left atrium during pulmonary vein isolation (PVI). Although it is an attractive strategy to avoid esophageal thermal injury, this technique was hampered by both the propensity for oropharyngeal trauma from the stiff stylet and the limited lateral esophageal displacement...
August 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30139482/bailout-atrial-balloon-septoplasty-to-overcome-challenging-left-atrial-transseptal-access-for-catheter-ablation-of-atrial-fibrillation
#20
Jackson J Liang, Sanghamitra Mohanty, Joe Fahed, Daniele Muser, David F Briceno, J David Burkhardt, Jeffrey S Arkles, Gregory E Supple, David S Frankel, Saman Nazarian, Fermin C Garcia, David J Callans, Sanjay Dixit, Luigi Di Biase, Andrea Natale, Francis E Marchlinski, Pasquale Santangeli
OBJECTIVES: This study reports outcomes of bailout atrial balloon septoplasty (ABS) to overcome challenging left atrial (LA) access in patients undergoing atrial fibrillation (AF) ablation. BACKGROUND: Transseptal puncture (TSP) and LA access for AF ablation can be challenging in patients with prior atrial septal surgery, percutaneous closure, or scarred septum due to multiple prior TSPs. METHODS: The study identified patients who underwent AF ablation at 2 ablation centers from 2011 to 2017 with challenging TSP in whom bailout percutaneous ABS was performed to allow LA access...
August 2018: JACC. Clinical Electrophysiology
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