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Ocular Oncology and Pathology

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https://www.readbyqxmd.com/read/29134185/infiltrative-intraocular-conjunctival-squamous-cell-carcinoma-after-local-resection-and-brachytherapy-clinical-and-pathological-findings
#1
Magnolia Trinidad Cano-Suárez, María Antonia Saornil-Álvarez, Ciro García-Álvarez, Francisco López-Lara, Jesús María Frutos-Baraja, Elena García-Lagarto
A pseudophakic 70-year-old man presented to the clinic with a slow-growing conjunctival mass in the left eye. He was diagnosed with a conjunctival exophytic lesion suspicious of invasive conjunctival squamous cell carcinoma (CSCC). Excisional biopsy showed a well-differentiated CSCC with positive margins and the patient underwent adjuvant brachytherapy. Six weeks later, examination of the anterior segment revealed cells in the anterior chamber and a neurotrophic corneal ulcer with corneal perforation. Considering the high suspicion of intraocular invasion of CSCC, the left eye was enucleated...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29134184/extranodal-marginal-zone-lymphoma-of-ocular-adnexa-outcomes-following-radiation-therapy
#2
Sean Platt, Yahya Al Zahrani, Nakul Singh, Brian Hill, Sheen Cherian, Arun D Singh
Aim: The aim of this study was to report outcomes following radiation therapy in patients with biopsy-proven extranodal marginal zone lymphoma of the ocular adnexa and uvea. Methods: Records from a single institution were retrospectively reviewed from January 1997 to December 2015. The mean follow-up duration was 38 months (range 0-194). Radiation therapy was administered to 77 eyes (60 patients); 57 of the 77 eyes (74%) were treated with radiation only (range 20-36 Gy, median 15 fractions)...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29134183/pigmented-spindle-cell-nevus-of-reed-of-the-eyelid
#3
Melina I Morkin, Mitesh K Kapadia, Nora V Laver
Purpose: To report the clinical, pathological, and immunohistochemical features of the first pigmented spindle cell nevus (PSCN) of Reed documented to have appeared in the eyelid. Methods: The findings of clinical and histopathological examination are presented, along with differential diagnoses and a review of the pertinent literature. Case: A 3-year-old boy presented with a rapidly growing, heavily pigmented left lower lid papule raising the concern of malignancy, warranting excisional biopsy...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29134182/high-dose-2-5-mg-intravitreal-bevacizumab-as-rescue-therapy-for-persistent-postradiation-cystoid-macular-edema
#4
Mohammed Ali Khan, Arman Mashayekhi, Kyle Ferguson, Jerry A Shields, Carol L Shields
Background/Aims: To investigate the efficacy of intravitreal high-dose (2.5 mg/0.1 mL) bevacizumab as rescue therapy for postradiation cystoid macular edema (CME) resistant to standard-dose (1.25 mg/0.05 mL) bevacizumab. Methods: Retrospective, interventional case series. Results: Fifteen eyes of 15 patients were included. Eyes were treated with a mean of 10 standard-dose (1.25 mg) bevacizumab injections but failed to show CME resolution. Following 3 monthly treatments of high-dose (2...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071276/small-choroidal-melanoma-revealed-by-a-large-extrascleral-extension
#5
Stéphanie Lemaître, Mathieu Zmuda, Pierre Vincent Jacomet, Christine Lévy-Gabriel, Rémi Dendale, Olivier Berges, Paul Fréneaux, Pascale Mariani, Laurence Desjardins, Olivier Galatoire, Nathalie Cassoux
AIMS: Orbital extraocular extension of choroidal melanoma is very rare with small melanomas. We report the case of a patient whose small choroidal melanoma was initially overlooked and was revealed by a large extrascleral extension. METHODS: A 48-year-old Caucasian woman presented with sudden total visual loss in the right eye. Multicolor imaging of the fundus showed right optic disc edema and an orange and green lesion near the optic disc. The diagnosis of unilateral optic neuritis was made...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071275/reactive-retinal-astrocytic-tumor-focal-nodular-gliosis-report-of-the-clinical-spectrum-of-3-cases
#6
Arun D Singh, Hansell Soto, Claudine Bellerive, Charles V Biscotti
PURPOSE: To report 3 cases providing insight into clinical progression of reactive retinal astrocytic tumor. METHODS: The clinical, imaging, and when available, the cytologic features of 3 cases of reactive retinal astrocytic tumor (focal nodular gliosis) were reviewed. RESULTS: A 6-year-old female, a 49-year-old man, and a 39-year-old man each developed a white retinal mass associated with laser photocoagulation, lattice degeneration, and treatment of a presumed vascular tumor, respectively...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071274/bilateral-central-retinal-artery-occlusion-associated-with-bilateral-lymphoproliferative-infiltrative-optic-neuropathy
#7
Philip J DeSouza, Claudia G Hooten, Christopher M Lack, Vishak J John, Timothy J Martin
BACKGROUND: Leukemic infiltration of the optic nerve is relatively rare. While previously described in acute leukemia, the infiltration in our case represents central nervous system (CNS) metastasis of Burkitt-type lymphoma that developed as a complication of solid-organ transplantation, resulting in a bilateral infiltrative optic neuropathy with sequential, bilateral central retinal artery occlusion (CRAO) and devastating vision loss. METHODS: The medical record, serial ophthalmic examination findings, clinical course, and imaging including magnetic resonance imaging (MRI), fundus photographs, and fluorescein angiography of a single patient were retrospectively reviewed...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071273/chronic-lymphocytic-leukaemia-small-cell-lymphocytic-lymphoma-of-the-lacrimal-sac-a-case-series
#8
Yamini Krishna, Luciane D Irion, Sozan Karim, Aruna Dharmsena, Austin McCormick, Sarah E Coupland
BACKGROUND: Lymphomas of the lacrimal sac are rare, accounting for less than 10% of lacrimal sac malignant tumours. They may present with symptoms typical of secondary acquired nasolacrimal duct obstruction and are thus often misdiagnosed. METHODS: Case series and literature review. RESULTS: Herein we describe 3 cases of chronic lymphocytic leukaemia (CLL)/small-cell lymphocytic lymphoma (SLL) of the lacrimal sac with immunohistochemical and in 1 case molecular confirmation...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071272/conjunctival-blue-naevus-in-an-anophthalmic-socket
#9
Hibba Quhill, Paul A Rundle, Hardeep Singh Mudhar
PURPOSE OF THE STUDY: To describe an unusual brown pigmented lesion of the conjunctiva in an anophthalmic socket in a 16-year-old male. PROCEDURES: A 16-year-old male patient presented with socket irritation whilst wearing an artificial eye due to meibomian gland dysfunction. An area of flat, subepithelial, dark brown pigmentation with irregular and indistinct borders on the bulbar conjunctiva of the anophthalmic socket was seen. The patient believed it had been present for at least 2 years...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071271/monte-carlo-estimation-of-absorbed-dose-distributions-obtained-from-heterogeneous-106-ru-eye-plaques
#10
Francisco J Zaragoza, Marion Eichmann, Dirk Flühs, Wolfgang Sauerwein, Lorenzo Brualla
BACKGROUND: The distribution of the emitter substance in (106)Ru eye plaques is usually assumed to be homogeneous for treatment planning purposes. However, this distribution is never homogeneous, and it widely differs from plaque to plaque due to manufacturing factors. METHODS: By Monte Carlo simulation of radiation transport, we study the absorbed dose distribution obtained from the specific CCA1364 and CCB1256 (106)Ru plaques, whose actual emitter distributions were measured...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071270/ciliary-body-mesectodermal-leiomyoma-diagnosed-by-fine-needle-aspiration-biopsy
#11
Hayyam Kiratli, Abdullah Ağın, Sevgen Önder
AIMS: To describe the clinical, imaging, cytopathological, and immunohistochemical features of mesectodermal leiomyoma of the ciliary body diagnosed by fine needle aspiration biopsy in a patient who denied any major intervention without prior pathological verification. METHODS: The clinical, imaging, and cytopathological records of the patient were retrospectively reviewed. A fine needle aspiration biopsy with a 25-G needle was performed after tailoring a scleral flap...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071269/iodine-125-brachytherapy-for-uveal-melanoma-a-systematic-review-of-radiation-dose
#12
REVIEW
Jose J Echegaray, Nikolaos E Bechrakis, Nakul Singh, Claudine Bellerive, Arun D Singh
AIM: To investigate whether lower radiation doses may yield similar outcome measures to those from the COMS trial. METHODS: A literature review of English language articles was performed using the PubMed database of the U.S. National Library of Medicine and the Cochrane Central Register of Controlled Trials using the following keywords: uveal melanoma, choroidal melanoma, primary uveal malignant melanoma, iodine-125 brachytherapy, local recurrence, local treatment failure, and local tumor control...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071268/development-of-ocular-rosacea-following-combined-ipilimumab-and-nivolumab-treatment-for-metastatic-malignant-skin-melanoma
#13
Niels J Brouwer, John B A G Haanen, Martine J Jager
PURPOSE: To report a case of severe ocular rosacea following ipilimumab plus nivolumab treatment in a patient with metastatic malignant skin melanoma. METHODS: Case report and review of the literature. RESULTS: A 68-year-old male with newly diagnosed metastatic malignant cutaneous melanoma was treated with first-line ipilimumab plus nivolumab, which resulted in a partial response. Four months after initiation of treatment, the patient developed red eyelids and conjunctivae, with painful gritty eyes, limiting his capacity to read...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071267/uveal-melanoma-cell-seeding-after-transretinal-tumor-biopsy
#14
Konrad R Koch, Ahmed M Hishmi, Monika Ortmann, Ludwig M Heindl
BACKGROUND/AIMS: To report a case and the histopathology of uveal melanoma cell seeding following transretinal tumor biopsy for a suspected uveal lesion. METHODS: Interventional case report. RESULTS: A 66-year-old male presented with a pigmented perilimbal episcleral lesion overlying an intraocular mass at the pars plana, 3.5 years after transretinal biopsy and ruthenium plaque brachytherapy for a choroidal melanoma at the posterior pole. The patient underwent enucleation of the eye...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071266/retinal-reactive-astrocytic-tumor-focal-nodular-gliosis-the-entity-also-known-as-vasoproliferative-tumor
#15
EDITORIAL
Hans E Grossniklaus, Tamara L Lenis, Frederick A Jakobiec
No abstract text is available yet for this article.
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28868288/uveal-melanoma-with-histopathologic-intratumoral-heterogeneity-associated-with-gene-expression-profile-discordance
#16
Audra K Miller, Matthew J Benage, David J Wilson, Alison H Skalet
PURPOSE: To report a case of intratumoral gene expression profile discordance in a malignant uveal melanoma, associated with intratumoral heterogeneity based upon histopathologic features. METHODS: The clinical history, fundus findings, imaging and histopathologic features, and DecisionDx-UM gene expression profile results (Castle Biosciences, Inc., Phoenix, AZ, USA) of the tumor were reviewed. RESULTS: A trans-retinal fine-needle aspiration biopsy was performed for a thin, pigmented choroidal tumor in a 33-year-old man...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28868287/intracameral-chemotherapy-melphalan-for-aqueous-seeding-in-retinoblastoma-bicameral-injection-technique-and-related-toxicity-in-a-pilot-case-study
#17
Francis L Munier, Marie-Claire Gaillard, Sarah Decembrini, Massimo Bongiovanni, Maja Beck-Popovic
BACKGROUND: The anterior chamber has been shown by pharmacokinetic studies to represent a sanctuary never achieving a tumoricidal dose with the present administration routes, such as systemic, intra-arterial, or intravitreal injections. METHOD: A novel intracameral chemotherapy technique is described to control aqueous seeding in a pilot unilateral group E retinoblastoma case with primary aqueous seeding. Anterior segment toxicity was carefully monitored. RESULTS: Control of the retinal tumor and vitreous seeding was achieved by intra-arterial and intravitreal chemotherapies...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28868286/clinical-and-spectral-domain-optical-coherence-tomography-appearance-of-optic-disc-melanocytoma-a-new-classification-and-differentiation-from-pigmented-choroidal-lesions
#18
Supanut Apinyawasisuk, Tara McCannel, Anthony C Arnold
AIMS: The aim of this paper was to compare the features of both the classic, darkly pigmented and the atypical, more lightly pigmented optic disc melanocytoma with those of pigmented choroidal lesions. METHODS: We analyzed the spectral-domain optical coherence tomography (SD-OCT) features of 9 eyes with optic disc melanocytoma and compared them with those of choroidal melanoma and nevus. RESULTS AND CONCLUSION: We identified 2 categories of SD-OCT findings in optic disc melanocytoma: (a) type 1, the typical, prominent, hyperpigmented lesion with SD-OCT findings of a hyperreflective, disorganized overlying retina and a posterior hyporeflective shadow, and (b) the less common, atypical, minimally pigmented type 2 lesion overlaid by a relatively well-organized retina that lacks a posterior hyporeflective shadow...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28868285/systemic-braf-mek-inhibitors-as-a-potential-treatment-option-in-metastatic-conjunctival-melanoma
#19
REVIEW
Joel M Mor, Ludwig M Heindl
AIM: In this review, we outline similarities between conjunctival and skin melanoma as well as the effectiveness of combined BRAF/MEK inhibition in melanoma, and discuss the applicability of these agents in conjunctival melanoma. METHODS: The study provides a PubMed literature review. RESULTS: Conjunctival melanoma and skin melanoma are genetically and phenotypically related. Both tumors typically harbor BRAF mutations in more than 50% of cases...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28868284/eye-salvage-with-combination-of-intravitreal-and-intracameral-melphalan-injection-for-recurrent-retinoblastoma-with-anterior-chamber-involvement-report-of-a-case
#20
Nathalie Cassoux, Isabelle Aerts, Livia Lumbroso-Le Rouic, Paul Freneaux, Laurence Desjardins
AIMS: Herein we report successful eye salvage following combined intravitreal and intracameral administration of melphalan for anterior chamber recurrence of retinoblastoma. METHODS: A 12-month-old boy was referred with a sporadic bilateral retinoblastoma staged as group D and V in the right eye and group E and V in the left eye. Treatment initially involved 6 cycles of 3 drugs followed by focal treatments. The left eye was enucleated. Three months after the end of systemic chemotherapy, multiple recurrent lesions were noted in the ciliary body and the anterior chamber...
July 2017: Ocular Oncology and Pathology
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