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Ocular Oncology and Pathology

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https://www.readbyqxmd.com/read/29765955/pediatric-multiple-endocrine-neoplasia-type-2b-clinicopathological-correlation-of-perilimbal-mucosal-neuromas-and-treatment-of-secondary-open-angle-glaucoma
#1
Ta Chen Chang, Kingsley C Okafor, Kara M Cavuoto, Sander R Dubovy, Carol L Karp
Ocular findings of multiple endocrine neoplasia type 2B (MEN 2B) include prominent corneal nerves, mucosal neuromas of the conjunctiva, glaucoma, and dry eyes. A 15-year-old girl with MEN 2B presents with advanced secondary open-angle glaucoma and bilateral perilimbal masses. High-resolution optical coherence tomography (HR-OCT) of the perilimbal lesions showed normal epithelial thickness and subepithelial lobular areas of mixed reflectivity, which correlates well with histopathologic findings of benign mucosal neuromas...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29765954/an-unusual-presentation-of-esthesioneuroblastoma-in-a-young-pregnant-female
#2
Meenakshi Wadhwani, Amar Ranjan, Kulbhushan Gangwani, Prasenjit Das
Background: Esthesioneuroblastoma is a rare neuroepithelial tumor arising from the olfactory epithelium in the cribriform plate or nasal cavity. It accounts for 1-5% of cases of malignant neoplasms of the nasal cavity. Methods: A 20-year-old pregnant female presented with painful loss of vision in both eyes, on imaging diagnosed as meningioma. There was a progressive increase in pain along with diminution of vision to the extent of complete loss of vision in the right eye...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29765953/response-to-comparison-of-gene-expression-profiling-and-chromosome-3-analysis-by-fluorescent-in-situ-hybridization-and-multiplex-ligation-probe-amplification-in-fine-needle-aspiration-biopsy-specimens-of-uveal-melanoma
#3
https://www.readbyqxmd.com/read/29765952/malignant-orbital-meningioma-originating-from-the-frontal-lobe
#4
Giancarlo A Garcia, Andrew E Choy, Anton N Hasso, Don S Minckler
Purpose of the Study: Orbital meningiomas are typically benign tumors, most commonly originating from the dura of the sphenoid wing or the optic nerve sheath. Procedures: We describe an unusual case of a malignant meningioma originating from the frontal lobe that ultimately produced orbital and distant metastases. Results and Conclusions: Orbital invasion by the meningioma was preceded by multiple incomplete resections, which may have facilitated access to the orbit...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29765951/advanced-midzonal-iris-pigment-epithelial-cyst-managed-by-aspiration-deflation
#5
Jerry A Shields, Samuel J Fallon, Charlotte Nelle Shields, Sara E Lally, Carol L Shields
Background: There are several cysts that can occur in the iris. The midzonal (retroiridic) iris pigment epithelial (IPE) cyst is important because it can simulate melanoma of the ciliary body. However, it is frequently asymptomatic and requires no treatment. Methods: A 37-year-old asymptomatic woman with visual acuity of 20/20 in each eye was found to have an elevated mass behind the left iris, presumed to be melanoma, and was referred for management. On our examination, there was a typical midzonal IPE cyst in the left eye (OS), requiring observation without intervention...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29765950/early-neuroblastic-and-astrocytic-differentiation-demonstrated-immunohistochemically-in-a-small-intraocular-medulloepithelioma
#6
Frederick A Jakobiec, Fouad R Zakka, Thanos Papakostas, Shizuo Mukai
Purpose: To investigate the source of fibrous astrocytes and neuroblasts in a small ciliary body medulloepithelioma appearing as a leukocoria in a 3-week-old baby girl. Methods: Histopathologic and immunohistochemical studies included Alcian blue, periodic acid-Schiff, and antisera for the detection of S100 protein, CD99, glial fibrillary acidic protein (GFAP), CRX, NeuN, neurofilaments, synaptophysin, desmin, and myogenin. Results: A small, nonteratoid ciliary body medulloepithelioma with collections of Alcian blue+ mucoplysaccharides was present in the enucleated globe...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29765949/a-20-year-retrospective-review-of-retinoblastoma-at-two-tertiary-academic-hospitals-in-johannesburg-south-africa
#7
Saadiah Goolam, Hemant Kana, Nicky Welsh, Linda Wainwright, Janet Poole, Ismail Mayet
Aim: This paper presents a 20-year review of retinoblastoma in Johannesburg, South Africa, aiming to better characterize the disease in this sub-Saharan setting. Methods: The study represents a retrospective case series of retinoblastoma patients presenting to Charlotte Maxeke Johannesburg Academic Hospital and Chris Hani Baragwanath Academic Hospital between January 1, 1992, and December 31, 2011. Results: The total number of cases identified was 282, with 245 meeting the study inclusion criteria...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29765948/congenital-orbital-rhabdomyosarcoma
#8
Masoomeh Eghtedari, Amir Reza Farsiani, Mohammad Reza Bordbar
Rhabdomyosarcoma (RMS) is the most common malignant tumor of the orbit in children, but it is rarely present at birth. We report a large congenital orbital RMS with intracranial extension in a newborn baby. A newborn baby girl was referred to our hospital due to severe right-eye exophthalmia. Imaging studies showed an orbital mass with intracranial extension. Treatment was started with a course of neoadjuvant chemotherapy followed by right orbital exenteration and intracranial resection of the tumor. Histologic examination of the mass showed undifferentiated malignant small-cell tumor...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29765947/leser-tr%C3%A3-lat-syndrome-in-a-male-with-breast-carcinoma-and-eyelid-basal-cell-carcinoma
#9
Rajiv Garg, Siddharth Madan, Pragya Prakash, Ram Chander, Monisha Choudhary
Purpose: Leser-Trélat syndrome consists of appearance of a solid tumor-like carcinoma breast, colon, or stomach following eruption of multiple seborrheic keratoses (SK) of the skin. We present an unusual and possibly the first case report of Leser-Trélat syndrome in a male patient with a history of mastectomy for breast carcinoma who presented to us with a second malignancy in the form of basal cell carcinoma (BCC) of the lower eyelid. Procedure: A 75-year-old male presented in 2014 with a history of modified radical mastectomy for infiltrating ductal carcinoma of the left breast which was performed 11 years prior to the day of presentation...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29765946/radiation-retinopathy-47-years-following-brachytherapy-for-retinoblastoma
#10
Claudine Bellerive, Arun D Singh
A 50-year-old female who had undergone enucleation in the left eye and brachytherapy in the right eye for retinoblastoma at the age of 2 years was diagnosed with nonproliferation radiation retinopathy 47 years following the initial treatment. The patient had noticed black spots in her vision (scotomas) that interfered with reading. New onset of microaneurysms and lipid exudation threatening the foveola was noted on examination of the right eye. Initial visual acuity (VA) was 20/25. Optical coherence tomography showed no evidence of macular edema, but parafoveal lipid exudation was present...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29765945/atypical-fibroxanthoma-of-the-bulbar-conjunctiva-a-unique-case-describing-the-pathology-clinical-presentation-and-management
#11
Justin Kuiper, Ankit Shah, Rebecca Kuennen, Lynn Schoenfield
Background/Aims: Atypical fibroxanthoma is an uncommon tumor that usually occurs in the skin of the head and neck of the elderly with significant sun exposure. We describe a unique case featuring a rare ocular surface conjunctival tumor (atypical fibroxanthoma) and provide insight on its characteristic clinical features, surgical management, and histology. Methods: A 71-year-old male fisherman with no pertinent ocular history presented to an academic center with a rapidly enlarging bulbar conjunctival mass in the right perilimbal region for the past several months...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29765944/uveal-melanoma-5-year-update-on-incidence-treatment-and-survival-seer-1973-2013
#12
Mary E Aronow, Allan K Topham, Arun D Singh
Purpose: To analyze trends in incidence, treatment, and survival of uveal melanoma in the United States from 1973 to 2013 using the Surveillance, Epidemiology, and End Results database. Materials and Methods: Patients were identified using International Classification of Disease for Oncology codes: C69.3 (choroid), C69.4 (ciliary body and iris), and C69.2 (retina). Trends in age-adjusted incidence, treatment (surgery or radiation), and 5-year relative survival were calculated...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29765943/juvenile-xanthogranuloma-in-a-pediatric-patient-with-langerhans-cell-histiocytosis
#13
Radha Ram, Marissa D Marolf, Patricia Chévez-Barrios, Honey H Herce
Purpose: To report a case of juvenile xanthogranuloma that simulated a chalazion and to discuss the association between juvenile xanthogranuloma and Langerhans cell histiocytosis. Method: Case report and review of literature. Results: A 13-year-old boy with a prior history of Langerhans cell histiocytosis was referred to our clinic for a possible chalazion. The patient had undergone treatment for Langerhans cell histiocytosis 10 years prior...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29765942/malpractice-litigation-in-ocular-oncology
#14
Stephanie B Engelhard, Mary E Aronow, Christopher T Shah, Austin J Sim, Ashvini K Reddy
Aims: The aim of this study was to report and analyze the causes and outcomes of ocular oncology malpractice litigation. Methods: The WestLaw® database was reviewed for all litigation related to ophthalmology in the United States from 1930 to 2014. All ocular oncology cases were included in this analysis and compared to other ophthalmic subspecialties. Results: Sixteen ocular oncology malpractice cases were included in this study. Overall, 56...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344502/orbital-epstein-barr-virus-positive-polymorphic-b-cell-lymphoproliferative-disorder-in-an-apparently-immunocompetent-woman
#15
Michael D Abendroth, Michael G Bayerl, Michael J Wilkinson, David F Claxton, Charles S Specht
We report a rare case of Epstein-Barr virus (EBV)-positive polymorphic B-cell lymphoproliferative disorder (LPD) involving the lacrimal gland of a 28-year-old, apparently immunocompetent woman. She presented with a chief complaint of orbital swelling and tenderness and was found to have a lesion involving the right lacrimal gland and distal superior and lateral rectus muscles. Histology of the lesion revealed histiocytes with pleomorphic nuclei, reactive lymphocytes, and scattered cells that resembled the Reed-Sternberg (R-S) cells of classical Hodgkin lymphoma...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344501/pigmented-epithelioid-melanocytoma-of-the-cheek-orbit-and-intracranial-cavity-a-case-report
#16
Erik R Johnson, Michael E Korchak, Todd A Goodglick, Jasbir S Johal, Craig R Dufresne, Sina J Sabet
Pigmented epithelioid melanocytoma (PEM) of the skin has been rarely reported in ophthalmology. The purpose of this case report is to present a young male born with a progressive, hyperpigmented lesion involving the orbit and intracranial cavity diagnosed as PEM. The case is unique given the young age and the size, multifocality, and growth of this tumor. Identification of this lesion is paramount due to its low-grade malignant potential.
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344500/pilot-study-of-a-large-eye-surgically-induced-dry-eye-rabbit-model-by-selective-removal-of-the-harderian-lacrimal-and-meibomian-glands
#17
Arthur S Polans, Jonathan F McAnulty, Paul O Phelps, Soesiawati R Darjatmoko, Christopher K Burris, Daniel M Albert
Background/Aims: Establish a reliable rabbit dry eye (DE) model. Methods: An interventional cohort study surgically removing glands contributing to the tear film. Eight rabbits were studied after removal of left lacrimal, Harderian, or both glands. Additional rabbits had Meibomian glands in the left eye thermally obstructed. All were followed for 10 weeks with phenol red thread (PRT) and slit-lamp examination with 2% fluorescein. We assessed corneal sensitivity using a Cochet-Bonnet esthesiometer...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344499/unilateral-multifocal-choroidal-melanoma
#18
Debarshi Mustafi, Bertil Damato, Jesse L Berry
We report a case of multifocal choroidal melanoma in the same eye, separated in presentation by 20 years. A 57-year-old Caucasian male initially presented with a choroidal melanoma of the right eye that was treated with transpupillary thermotherapy. Due to recurrence, the patient underwent proton beam therapy with subsequent tumor regression. A second small choroidal lesion was noted in the right eye during his surveillance examinations that was closely monitored and demonstrated stable dimensions and features suggestive of a choroidal nevus...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344498/selective-intra-arterial-embolization-for-advanced-extrascleral-uveal-melanoma
#19
Víctor M Villegas, Mariola Monagas, Joseph Campbell, Timothy G Murray, Luis Serrano
Purpose: To report a treatment approach for advanced extrascleral uveal melanoma. Methods: We performed clinical examination including magnetic resonance imaging, computed tomography, angiography, and histopathologic analysis. Case: A 49-year-old healthy woman presented with a 7-year history of an enlarging pigmented mass in her right orbit. Malignant melanoma was diagnosed after biopsy with immunohistochemical stains. Treatment included selective intra-arterial embolization...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344497/a-case-of-adenocarcinoma-of-the-retinal-pigment-epithelium-an-immunohistochemical-and-electron-microscopic-study
#20
Hidetsugu Mori, Kanji Takahashi
Purpose: Retinal pigment epithelium (RPE) adenocarcinoma is a very rare malignant intraocular tumor. Herein we describe the histopathological features of RPE adenocarcinoma. Case: A 36-year-old male was referred to our clinic because of floaters in his left eye. The initial diagnosis was malignant melanoma of the choroid. We resected the tumor and studied it histopathologically. The tumor tissue was investigated by light microscopy including immunohistochemistry using antibodies against S-100, HMB-45, EMA, and AE-1...
December 2017: Ocular Oncology and Pathology
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