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Ocular Oncology and Pathology

Yahya A Alzahrani, Smita Kumar, Hassan Abdul Aziz, Thomas Plesec, Arun D Singh
AIM: To assess the use of anterior segment optical coherence tomography (OCT) as an adjuvant diagnostic tool in primary acquired melanosis (PAM) by correlating clinical, histopathologic and anterior segment OCT findings. METHODS: Twenty-four patients (24 eyes) with PAM of the conjunctiva, cornea or both were imaged with an anterior segment OCT device (RTVue, model-RT100; Optovue Inc., Fremont, Calif., USA). RESULTS: Histopathologic diagnosis following excisional or incisional biopsy was confirmed in 13 out of 24 patients (54...
April 2016: Ocular Oncology and Pathology
Omair B Ali, Ryan Deroque, R Grant Morshedi, Harry Brown
PURPOSE: Conjunctival biopsies may contain polarizable material in patients with sarcoidosis despite no history of prior trauma or eye surgeries. PROCEDURES: A 39-year-old male with uveitic glaucoma presented with decreased vision and throbbing pain in his right eye. His intraocular pressure was elevated, and his vision was reduced to hand motion. Due to persistently elevated intraocular pressure refractory to medical treatment, the patient underwent a glaucoma drainage device procedure...
April 2016: Ocular Oncology and Pathology
Sophie Stenton, Malee Fernando, Zanna Currie, Hardeep Singh Mudhar
PURPOSE: To describe the ophthalmic and histopathological features of a female with granulomatous common variable immunodeficiency (CVID) who presented with upper-lid swelling. PROCEDURES: The patient underwent a biopsy of the right upper lid/palpebral lacrimal gland with imaging showing a left-sided nasopharyngeal mass, multiple lymph nodes within the mediastinum, bilateral lung nodules and a peritoneal nodule in the right iliac fossa. The right upper-lid swelling progressed and was subject to a second biopsy...
April 2016: Ocular Oncology and Pathology
Cláudia M Chaves, Claudio Chaves, Pablo Zoroquiain, Rubens Belfort, Miguel N Burnier
Gnathostomiasis is a parasitic disease caused by nematode larvae ingestion of 15 known species of the genus Gnathostoma (one of the Gnathostomatidae family members). This parasite uses freshwater fish as a host and can infect - through the consumption of raw fish or their viscera - other animals such as dogs, cats, chickens, pigs, and humans. This parasitic disease, with humans acting as hosts, has been known since 1945 (India), and ocular complications have been known since 2004 (intravitreal; also described in India)...
April 2016: Ocular Oncology and Pathology
Robert M Verdijk
Medulloepithelioma is a rare congenital tumor of the ciliary body and iris. The current classification and grading of medulloepithelioma shows inconsistencies and does not reflect clinical behavior. This position paper discusses the backgrounds of the current classification and intends to initiate a discussion on an alternative classification and grading scheme.
April 2016: Ocular Oncology and Pathology
Catherine Y Liu, Marc A Yonkers, Tiffany S Liu, Don S Minckler, Jeremiah P Tao
A 34-year-old patient presented with a right orbito-facial mass since childhood, consistent with a congenital arteriovenous (AV) malformation. Prior to presentation, she had multiple incomplete surgical resections and embolizations with N-butyl acetyl acrylate and Onyx-18. The patient reported gradual, progressive vision loss shortly after Onyx-18 embolization. Five months after embolization, she presented with decreased vision, disfigurement and mechanical ptosis relating to a large subcutaneous mass affecting the medial right upper eyelid and forehead...
April 2016: Ocular Oncology and Pathology
Patricia Y Akinfenwa, Patricia Chévez-Barrios, Clio A Harper, Dan S Gombos
BACKGROUND/AIMS: Retinoblastoma (Rb) generally presents in children <8 years of age. Aicardi syndrome (AS) is a congenital, neurodevelopmental disorder that has been associated with various ophthalmic abnormalities, but no reports have related it to a delayed presentation of Rb. This report describes the late presentation of Rb in a teenage patient with AS and suggests modifications in ophthalmic screening to facilitate early detection. METHODS: A chart review was conducted of a patient with AS...
April 2016: Ocular Oncology and Pathology
Arun D Singh, Sean M Platt, Lisa Lystad, Mark Lowe, Sehong Oh, Stephen E Jones, Yahya Alzahrani, Thomas Plesec
PURPOSE: The purpose of this study was to correlate high-resolution magnetic resonance imaging (MRI) and histologic findings in a case of juxtapapillary choroidal melanoma with clinical evidence of optic nerve invasion. METHODS: With institutional review board approval, an enucleated globe with choroidal melanoma and optic nerve invasion was imaged using a 7-tesla MRI followed by histopathologic evaluation. RESULTS: Optical coherence tomography, B-scan ultrasonography, and 1...
April 2016: Ocular Oncology and Pathology
Jasmine H Francis, Thomas Wiesner, Tatyana Milman, Helen H Won, Amy Lin, Vivian Lee, Daniel M Albert, Robert Folberg, Michael F Berger, Devron H Char, Brian Marr, David H Abramson
PURPOSE: The aim of this study was to use massively parallel DNA sequencing to identify GNAQ/11, BAP1 and SF3B1 mutations in ophthalmic melanocytoma. PROCEDURES: Six ophthalmic melanocytoma specimens (1 iridociliary and 5 optic nerve) were profiled for genomic alterations in GNAQ/11, BAP1 and SF3B1 using a custom deep sequencing assay. This assay uses solution phase hybridization-based exon capture and deep-coverage massively parallel DNA sequencing to interrogate all protein-coding exons and select introns...
April 2016: Ocular Oncology and Pathology
Avni V Patel, John B Miller, Rajneesh Nath, Helen A Shih, Michael K Yoon, Suzanne K Freitag, George Papaliodis, Teresa C Chen, Dean Eliott, Ivana K Kim
BACKGROUND/AIM: Unilateral choroidal infiltration as the initial manifestation of leukemic relapse in adults is rare, particularly after an extended period of remission. This report describes this unique ophthalmic presentation, highlights the associated diagnostic challenges, and reviews the literature. METHODS: Two cases are described and an extensive literature review was conducted. RESULTS: A 59-year-old male with acute lymphoid leukemia, in remission for 18 months, presented with unilateral scleritis, exudative retinal detachment, and choroidal thickening...
April 2016: Ocular Oncology and Pathology
Kevin M Halenda, Ragini R Kudchadkar, David H Lawson, Darren D Kies, Kristen E Zhelnin, Alyssa M Krasinskas, Hans E Grossniklaus
AIM: The aim of this study was to report a case of metastatic uveal melanoma in which radioembolized nodular liver metastases decreased in size while infiltrative sinusoidal metastases progressed, leading to jaundice without obstruction of the biliary ducts. METHODS: The relevant clinical features, imaging, and histopathologic findings of this case are reviewed. RESULTS: A 61-year-old Caucasian male with a history of uveal melanoma of the left eye status post plaque brachytherapy developed numerous liver metastases...
April 2016: Ocular Oncology and Pathology
Hardeep Singh Mudhar, Murtuza Nuruddin, Soma Rani Roy
PURPOSE: The aim of this study was to report the clinical and histopathological features of an eyelid metastasis in a 70-year-old male with no prior medical history. METHODS: A 70-year-male presented with a painless, hard, red nodular growth in his left lower medial eyelid of 6 months duration, involving the canaliculus and punctum. He did not complain of any other ocular or systemic abnormality. The clinical differential diagnosis included lymphoma or a primary adnexal tumour...
April 2016: Ocular Oncology and Pathology
Hassan A Aziz, Yasha S Modi, Thomas P Plesec, Arun D Singh
PURPOSE: To report a case of an amelanotic irido-ciliary ring melanoma. DESIGN: Interventional case report. RESULTS: A 44-year-old male was followed for asymptomatic amelanotic iris nevus of the right eye that was noted to have a localized ciliary body mass with ring extension along the trabecular meshwork. Fine needle aspiration biopsy was consistent with malignant melanoma. The patient underwent enucleation and remains disease free at 9 years of follow-up...
April 2016: Ocular Oncology and Pathology
Jesse L Berry, David Cobrinik, Jonathan W Kim
PURPOSE: To report the use of handheld spectral-domain optical coherence tomography (HHSD OCT) to identify and define the intraretinal location of a small retinoblastoma that was not detectable by indirect ophthalmoscopy. METHODS: This is a retrospective case report of a tumor identified with HHSD OCT in a single patient. RESULTS: A 7-week-old male was diagnosed with unilateral group E retinoblastoma in the right eye. An enucleation was completed successfully with histopathologic confirmation of the diagnosis...
April 2016: Ocular Oncology and Pathology
Hayyam Kiratli, İrem Koç, Berçin Tarlan
AIMS: To report a patient with unrecognized small macular melanoma, who gradually developed neovascular glaucoma that was treated with an Ahmed valve. We presume that tumor cells gained access to the orbit through this aqueous drainage device. METHODS: The medical records pertaining to 5 different centers, the results of imaging studies, the clinical course of the patient and histopathological findings were retrospectively reviewed. RESULTS: A 61-year-old man presented with a blind and painful proptotic right eye...
April 2016: Ocular Oncology and Pathology
Naina Gupta, William Terrell, Lynn Schoenfield, Claudia Kirsch, Colleen M Cebulla
BACKGROUND/AIMS: To report a case and the unique histopathology of a necrotic uveal melanoma mimicking advanced Coats' disease in a young adult. METHOD: A 26-year-old male presented with a blind, painful eye, total exudative retinal detachment, and bulbous aneurysms consistent with Coats' disease. No masses were visualized on ultrasound or CT scan, and the patient underwent enucleation of the eye. RESULTS: Histopathology of the involved eye confirmed a necrotic uveal melanoma with persistent spindle cells forming a collar around residual tumor vessels...
April 2016: Ocular Oncology and Pathology
Jordan R Hill, Zélia M Corrêa
PURPOSE: The aim of this study was to describe the side effects of I-125 brachytherapy in the treatment of uveal melanoma. METHODS: This study was conducted as a case report. RESULTS: We report a case of scleral necrosis and protruding episcleral mass following the treatment of uveal melanoma with I-125 brachytherapy. CONCLUSIONS: Scleral necrosis after plaque radiotherapy can clinically simulate tumor recurrence with extraocular extension...
April 2016: Ocular Oncology and Pathology
Serdar Yavuzyigitoglu, Emine Kilic, Jolanda Vaarwater, Annelies de Klein, Dion Paridaens, Robert M Verdijk
PURPOSE: The aim of this study was to describe a case of lipomatous change in uveal melanoma. PROCEDURES: The patient presented with a 2-year history of blurry vision. A full examination of the right eye revealed a dome-shaped pigmented subretinal mass in the choroid with a thickness of 9 mm and a diameter of 15 mm. The eye was enucleated and prepared for histopathologic, genetic and molecular investigation. RESULTS: Histopathology revealed a small circumscribed area consisting of mature adipocytic appearing cells with abundant clear cytoplasm and small peripheral flattened nuclei within a spindle-cell melanoma of the uvea...
April 2016: Ocular Oncology and Pathology
Peter G Traine, Katharina J Schedler, Eduardo B Rodrigues
Retinoblastoma is the most common childhood cancer. Thanks to modern technology and good medical access, mortality in Europe has decreased to about 5%. Diffuse infiltrating retinoblastoma is a very rare subtype of this neoplasm and is characterized by its atypical growth pattern. Diffuse infiltrating retinoblastoma may mimic other more innocuous diseases and may therefore be misdiagnosed. The purpose of this paper was to provide a short review of the main symptoms of diffuse infiltrating retinoblastoma presenting to the ophthalmologist and give a comparison to typical retinoblastoma...
April 2016: Ocular Oncology and Pathology
Dagny Zhu, Jesse L Berry, Lilangi Ediriwickrema, Kenneth Wong, Thomas C Lee, A Linn Murphree, Jonathan W Kim, Rima Jubran
BACKGROUND/AIMS: Chemoreduction protocols for retinoblastoma vary widely across institutions. Herein, we compare a 3- versus 6-cycle chemotherapy approach for group B retinoblastoma. METHODS: A nonrandomized, retrospective review of patients diagnosed with group B retinoblastoma from 1991-2011 at Children's Hospital Los Angeles was performed. A total of 72 eyes of 63 patients were analyzed. Mean follow-up time was 82 months (range 6-272 months). Main outcome measures were globe salvage and need for external beam radiation...
December 2015: Ocular Oncology and Pathology
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