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Ocular Oncology and Pathology

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https://www.readbyqxmd.com/read/28275608/design-and-implementation-of-the-retinoblastoma-collaborative-laboratory
#1
Seemi Qaiser, Alice Limo, Josiah Gichana, Kahaki Kimani, Jessie Githanga, Wairimu Waweru, Elizabeth A O Dimba, Helen Dimaras
PURPOSE: The purpose of this work was to describe the design and implementation of a digital pathology laboratory, the Retinoblastoma Collaborative Laboratory (RbCoLab) in Kenya. METHOD: The RbCoLab is a central lab in Nairobi that receives retinoblastoma specimens from all over Kenya. Specimens were processed using evidence-based standard operating procedures. Images were produced by a digital scanner, and pathology reports were disseminated online. RESULTS: The lab implemented standard operating procedures aimed at improving the accuracy, completeness, and timeliness of pathology reports, enhancing the care of Kenyan retinoblastoma patients...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275607/intracorneal-and-intraocular-invasion-of-ocular-surface-squamous-neoplasia-after-intraocular-surgery-report-of-two-cases-and-review-of-the-literature
#2
Juan C Murillo, Anat Galor, Michael C Wu, Natasha K Kye, James Wong, Ibrahim O Ahmed, Madhura Joag, Nabeel Shalabi, William Lahners, Sander Dubovy, Carol L Karp
PURPOSE: The aim of this paper was to describe 2 cases of ocular surface squamous neoplasia (OSSN) of the conjunctiva with intracorneal and intraocular extension following intraocular surgery. METHODS: We conducted a clinical pathological retrospective case series. RESULTS: Case 1 underwent cataract surgery in the setting of an unnoticed adjacent OSSN. An excisional biopsy with cryotherapy and intraoperative mitomycin C was subsequently performed, confirming OSSN...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275606/studies-on-the-histopathology-of-temporal-arteritis
#3
Angeline L Wang, Meisha L Raven, Krishna Surapaneni, Daniel M Albert
AIMS: The aim of this paper was to identify the location and to grade the severity of most significant inflammation within positive temporal artery biopsies along with other key clinical and histologic characteristics. METHODS: Charts and pathology slides for 70 patients diagnosed with temporal arteritis at the University of Wisconsin (UW) Hospital and Clinics from 1989 to 2015 were reviewed. A subset of 48 specimens was immunostained for CD68 and graded on a scale from 0 to +++; the location of staining was recorded...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275605/unrelenting-ocular-pain-as-a-masquerading-symptom-of-occult-choroidal-metastasis
#4
Jordan D Deaner, Renelle Pointdujour-Lim, Emil Anthony T Say, Carol L Shields
PURPOSE: To report a case of chronic eye pain as a presenting feature of choroidal metastasis from lung cancer. METHODS: We report the case of a 58-year-old Caucasian woman with stage IV lung adenocarcinoma presenting with an 8-month history of left eye pain and blurred vision. RESULTS: The patient had previously consulted 14 ophthalmologists with varying diagnoses including posterior scleritis and trigeminal neuralgia. Visual acuity at presentation was 20/20 in the right eye and 20/80 in the left eye...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275604/iphone-4s-and-iphone-5s-imaging-of-the-eye
#5
Maaz Jalil, Sandor R Ferenczy, Carol L Shields
BACKGROUND/AIMS: To evaluate the technical feasibility of a consumer-grade cellular iPhone camera as an ocular imaging device compared to existing ophthalmic imaging equipment for documentation purposes. METHODS: A comparison of iPhone 4s and 5s images was made with external facial images (macrophotography) using Nikon cameras, slit-lamp images (microphotography) using Zeiss photo slit-lamp camera, and fundus images (fundus photography) using RetCam II. RESULTS: In an analysis of six consecutive patients with ophthalmic conditions, both iPhones achieved documentation of external findings (macrophotography) using standard camera modality, tap to focus, and built-in flash...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275603/isolated-extranodal-natural-killer-t-cell-lymphoma-of-the-orbit-in-a-young-patient-complete-regression-with-the-smile-regimen
#6
Rachna Meel, Rebika Dhiman, Meenakshi Wadhwani, Seema Kashyap, Sanjay Sharma, Ajay Gogia
PURPOSE: Natural killer T-cell lymphoma (NKTL) is a highly malignant tumor that typically arises in the nose and/or paranasal sinuses. Isolated orbital involvement by NKTL is extremely rare, and only few case reports exist in the literature. Herein, we report a case of primary orbital NKTL in a young patient who showed very good response to chemotherapy with the SMILE regimen. METHODS: A 28-year-old healthy female presented to us with epiphora and fullness of the lower eyelid...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275602/occult-fungal-scleritis
#7
Lauren J Jeang, Aaron Davis, Brian Madow, Edgar M Espana, Curtis E Margo
PURPOSE: To heighten awareness of occult fungal scleritis. METHOD: Case report and review of the literature. RESULTS: A 73-year-old woman with diabetes mellitus was diagnosed for 3 months with immune-mediated scleritis and subsequently treated with corticosteroids. On referral, the patient had a scleral nodule with contiguous corneal infiltrate and hypopyon. Culture grew Fusarium species not further classified. The infection could not be controlled with antifungal therapy, and the eye was removed...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275601/acute-hemorrhagic-retinopathy-following-intravitreal-melphalan-injection-for-retinoblastoma-a-report-of-two-cases-and-technical-modifications-to-enhance-the-prevention-of-retinal-toxicity
#8
Hassan A Aziz, Jonathan W Kim, Francis L Munier, Jesse L Berry
AIMS: To report the occurrence of acute hemorrhagic retinopathy following intravitreal melphalan injection for retinoblastoma. METHODS: This is a retrospective case series of 2 patients with retinoblastoma treated with intravitreal melphalan for vitreous seeding who developed acute hemorrhagic retinopathy. RESULTS: Patient 1 is a 6-month-old female with bilateral retinoblastoma (Group D right eye and Group B left eye) treated with 4 cycles of systemic chemotherapy and 2 intravitreal melphalan injections in each eye...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275600/tyrosine-kinase-inhibitors-in-the-treatment-of-choroidal-metastases-from-non-small-cell-lung-cancer-a-case-report-and-review-of-literature
#9
Akshay Gopinathan Nair, Haresh T Asnani, Vinod C Mehta, Siddharth V Mehta, Rima S Pathak, Amit H Palkar, Indumati Gopinathan
BACKGROUND: Choroidal metastases being the sole presenting feature of lung cancer is rare. Erlotinib, a tyrosine kinase inhibitor (TKI), is used in the treatment of lung adenocarcinoma where tumor cells exhibit epidermal growth factor receptor (EGFR) mutations. We report a case of metastatic non-small-cell lung cancer (NSCLC) with choroidal metastasis, which was the sole presenting feature and which responded to erlotinib. METHODS: We performed a retrospective case review...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275599/ocular-surface-squamous-neoplasia-associated-with-atopic-keratoconjunctivitis
#10
Ankit Shah, Edgar M Espana, Arun D Singh
PURPOSE: To describe 2 cases of invasive squamous cell carcinoma that originated in the setting of severe atopic keratoconjunctivitis (AKC). METHODS: Case one involved a 73-year-old male with atopic eczema and severe AKC who developed a limbal lesion suspicious for ocular surface squamous neoplasia (OSSN). Slit-lamp examination was significant for a new sessile lesion in the temporal limbal region of the left eye. The lesion was treated with excisional biopsy and cryotherapy...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275598/bilateral-ocular-myositis-associated-with-whipple-s-disease
#11
Vivak Parkash, Hardeep Singh Mudhar, Bart E Wagner, Didier Raoult, Ruth Batty, Hubert Lepidi, John Burke, Paul Collini, Thushan de Silva
PURPOSE: To describe the clinical features of a Caucasian female patient with a history of treated gastrointestinal Whipple's disease (WD) who developed new-onset diplopia, with a description of the histopathological features of the extraocular muscle biopsies. METHODS: A previously fit 38-year-old Caucasian female presented with acute-onset diplopia after being on a sustained medication regime for biopsy-proven gastrointestinal WD. A magnetic resonance imaging scan of her orbits with gadolinium revealed diffuse enhancement of the bellies of the extraocular muscles bilaterally, particularly the medial rectus, superior rectus, and superior oblique muscles, consistent with an infiltrative myositis...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275597/congenital-orbital-teratoma
#12
Fernando Pellerano, Elvis Guillermo, Gloreley Garrido, Pedro Berges
We report a case of congenital orbital teratoma. A 3-day-old male, born at 39 weeks' gestation without relevant prenatal history, presented with a large vascularized proptotic mass distorting the left midface. Laboratory studies showed elevated serum alpha-fetoprotein (12,910 ng/ml). Computed tomography showed a multiloculated heterogeneous lesion composed of hypodense and hyperdense calcified areas encompassing the whole orbital cavity with expansion of the bony walls, as well as forward displacement and compression of the eyeball without extension to surrounding structures...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275596/an-unusual-location-of-fibrous-hamartoma-of-infancy-in-the-eyelid
#13
Ofira Zloto, Sarit Aviel-Ronen, Mordechai Rosner
AIM: To describe the clinical, imaging, and histopathological features of fibrous hamartoma of infancy (FHI) in the eyelid, a rare differential diagnosis for eyelid lesions. METHODS: We describe the case of a 7-month-old patient with a FHI in the eyelid that was diagnosed after surgical removal. The unique histopathological appearance of the triphasic histologic components provided the diagnosis. CONCLUSIONS: FHI is included in the long list of differential diagnosis for eyelid lesions in infancy...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275595/reactive-retinal-astrocytic-tumor-focal-nodular-gliosis-a-case-report
#14
Lauren E Hudson, Pia R Mendoza, Jiong Yan, Hans E Grossniklaus
PURPOSE: To report the clinical and histopathological findings of a reactive retinal astrocytic tumor (RRAT) that progressed to massive retinal gliosis. OBSERVATIONS: The patient presented with an elevated, white-yellow retinal mass and extensive retinal exudation in the left eye. Progressive enlargement of the mass and proliferative vitreoretinopathy eventually led to phthisis bulbi and enucleation. Histologically, the mass showed a predominant astrocytic component with intense glial fibrillary acidic protein staining, hyperplasia, fibrous metaplasia, and osseous metaplasia of the retinal pigment epithelium...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27843911/immunoglobulin-g4-related-ophthalmic-disease-involving-the-sclera-misdiagnosed-as-intraocular-tumor-report-of-one-case
#15
Hiroshi Goto, Shunichiro Ueda
AIMS: Immunoglobulin G4 (IgG4)-related disease is known to have diverse clinical manifestations. We report a case of IgG4-related ophthalmic disease misdiagnosed as intraocular tumor. METHODS: Case report. RESULTS: A 41-year-old man was referred to our department with a diagnosis of intraocular tumor, presumably choroidal melanoma. Although MR imaging was compatible with choroidal melanoma, he had been observed periodically without treatment because fundus findings were not typical of melanoma and visual function was preserved...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27843910/primary-orbital-cystic-pilocytic-astrocytoma
#16
Hardeep Singh Mudhar, Murtuza Nuruddin, Soma Roy
PURPOSE: To describe the clinical, radiological and histopathological features of a highly unusual primary orbital glioma. PROCEDURES: A 6-year-old female presented with right-sided proptosis that revealed a well-defined intraconal mass on CT imaging with intact orbital bony walls. During the removal of the lesion, it dissected away freely from the muscles and was separated from the optic nerve and globe. There was no communication with the brain. RESULTS: Histology showed histological features highly favouring a pilocytic astrocytoma enveloped by meninges...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27843909/melanoma-associated-spongiform-scleropathy-in-oculodermal-melanocytosis-with-primary-orbital-melanoma
#17
Roshni U Ranjit, Ilya M Leyngold, Curtis E Margo
PURPOSE: To describe spongiform scleropathy in a patient with oculodermal melanosis and without evidence of uveal melanoma. METHODS: Clinical-pathological correlation conducted in compliance with HIPPA (Health Insurance Privacy and Portability Act) regulations. RESULTS: Melanoma-associated spongiform scleropathy was an incidental finding in an 87-year-old woman with oculodermal melanocytosis treated for primary orbital melanoma. All previously reported cases of this scleropathy have been associated with uveal melanoma...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27843908/anterior-chamber-pathology-in-alagille-syndrome
#18
Derek K Ho, Alex V Levin, William V Anninger, David A Piccoli, Ralph C Eagle
BACKGROUND: Alagille syndrome is an autosomal dominant disorder characterized by neonatal cholestasis, characteristic facies, and cardiac abnormalities. Ocular abnormalities include posterior embryotoxon, mosaic pattern of iris stromal hypoplasia, microcornea, optic disc drusen, and pigmentary retinopathy. We present the second report of ocular pathology in two cases of Alagille syndrome. METHODS: Gross and histologic preparations of four eyes of two patients. RESULTS: Posterior embryotoxon is seen in both cases, with iris processes extending to the embryotoxon in case 1...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27843907/targeting-hmga2-in-retinoblastoma-cells-in-vitro-using-the-aptamer-strategy
#19
Venkatesan Nalini, Perinkulam Ravi Deepa, Rajeswari Raguraman, Vikas Khetan, Maddy Ashwin Reddy, Subramanian Krishnakumar
High-mobility group A2 (HMGA2) protein regulates retinoblastoma (RB) cancer cell proliferation. Here, a stable phosphorothioate-modified HMGA2 aptamer was used to block HMGA2 protein function in RB cells. HMGA2-aptamer internalisation in RB cells (Y79, Weri Rb1) and non-neoplastic human retinal cells (MIO-M1) were optimised. Aptamer induced dose-dependent cytotoxicity in RB cancer cells (0.25-1.5 µM). Increased expression of TGFβ, SMAD4, CDH1, BAX, CASP 3, PARP mRNA and decreased SNAI1, Bcl2 mRNA levels in aptamer-treated RB cells suggests the activation of TGFβ-SMAD4-mediated apoptotic pathway...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27843906/t2-fluid-attenuated-inversion-recovery-imaging-of-uveal-melanomas-and-other-ocular-pathology
#20
Gena M Damento, Kelly K Koeller, Diva R Salomão, Jose S Pulido
BACKGROUND/AIMS: This study describes patterns of intraocular lesions on T2 fluid-attenuated inversion recovery (FLAIR) imaging, exploring a prospective role of FLAIR imaging sequence in diagnosis and treatment. METHODS: A retrospective study of orbital magnetic resonance imaging (MRI) studies from the years 2000 to 2015 was performed. MRI sequences included: pre-contrast T1-weighted, T2-weighted, T2 FLAIR, and postcontrast T1 and T2 imaging gadolinium, which were evaluated by a neuroradiologist...
October 2016: Ocular Oncology and Pathology
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