Andras Garami, Alexandre A Steiner, Eszter Pakai, Samuel P Wanner, M Camila Almeida, Patrik Keringer, Daniela L Oliveira, Kazuhiro Nakamura, Shaun F Morrison, Andrej A Romanovsky
We identified the neural pathway of the hyperthermic response to TRPV1 antagonists. We showed that hyperthermia induced by i.v. AMG0347, AMG 517, or AMG8163 did not occur in rats with abdominal sensory nerves desensitized by pretreatment with a low i.p. dose of resiniferatoxin (RTX, TRPV1 agonist). However, neither bilateral vagotomy nor bilateral transection of the greater splanchnic nerve attenuated AMG0347-induced hyperthermia. Yet, this hyperthermia was attenuated by bilateral high cervical transection of the spinal dorsolateral funiculus (DLF)...
2023: Temperature: Multidisciplinary Biomedical Journal