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Journal of Pharmaceutics

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https://www.readbyqxmd.com/read/27885353/a-comparison-of-the-effects-of-alpha-and-medical-grade-honey-ointments-on-cutaneous-wound-healing-in-rats
#1
Shahram Paydar, Majid Akrami, Amirreza Dehghanian, Roshanak Alavi Moghadam, Mohsen Heidarpour, Amir Bahari Khoob, Behnam Dalfardi
Introduction. This study compared the healing efficacy and possible adverse effects of topical Alpha and medical-grade honey ointments on cutaneous wounds in rats. Methods. To conduct the study, 22 male Sprague-Dawley rats were randomly allocated into two equal groups: (1) rats with Alpha ointment applied to the wound surface area and (2) rats with medical-grade honey ointment applied to their wounds. The ointments were applied daily during the 21-day study period. Wound contraction was examined photographically with images taken on days 0, 7, and 21 after wounding...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27885352/formulation-and-evaluation-of-antibacterial-creams-and-gels-containing-metal-ions-for-topical-application
#2
Mei X Chen, Kenneth S Alexander, Gabriella Baki
Background. Skin infections occur commonly and often present therapeutic challenges to practitioners due to the growing concerns regarding multidrug-resistant bacterial, viral, and fungal strains. The antimicrobial properties of zinc sulfate and copper sulfate are well known and have been investigated for many years. However, the synergistic activity between these two metal ions as antimicrobial ingredients has not been evaluated in topical formulations. Objective. The aims of the present study were to (1) formulate topical creams and gels containing zinc and copper alone or in combination and (2) evaluate the in vitro antibacterial activity of these metal ions in the formulations...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27872792/porcine-pancreatic-lipase-inhibitory-agent-isolated-from-medicinal-herb-and-inhibition-kinetics-of-extracts-from-eleusine-indica-l-gaertner
#3
Siew Ling Ong, Siau Hui Mah, How Yee Lai
Eleusine indica (Linnaeus) Gaertner is a traditional herb known to be depurative, febrifuge, and diuretic and has been reported with the highest inhibitory activity against porcine pancreatic lipase (PPL) among thirty two plants screened in an earlier study. This study aims to isolate and identify the active components that may possess high potential as an antiobesity agent. Of the screened solvent fractions of E. indica, hexane fraction showed the highest inhibitory activity of 27.01 ± 5.68% at 100 μg/mL...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27847674/functional-performance-of-chitosan-carbopol-974p-nf-matrices-in-captopril-tablets
#4
Yuritze Alejandra Aguilar-López, Leopoldo Villafuerte-Robles
Chitosan and Carbopol have been used to form a complex through an electrostatic interaction between the protonated amine (NH3(+)) group of chitosan and the carboxylate (COO(-)) group of Carbopol. In situ polyelectrolyte complexes formations based on the physical mixture of chitosan and sodium alginate were found and could be used as an oral controlled release matrix. The aim of this work is the assessment of a possible interaction between the particles of chitosan and Carbopol 974P NF that could modify their technological performance in captopril tablets...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27822402/formulations-of-amlodipine-a-review
#5
REVIEW
Muhammad Ali Sheraz, Syed Furqan Ahsan, Marium Fatima Khan, Sofia Ahmed, Iqbal Ahmad
Amlodipine (AD) is a calcium channel blocker that is mainly used in the treatment of hypertension and angina. However, latest findings have revealed that its efficacy is not only limited to the treatment of cardiovascular diseases as it has shown to possess antioxidant activity and plays an important role in apoptosis. Therefore, it is also employed in the treatment of cerebrovascular stroke, neurodegenerative diseases, leukemia, breast cancer, and so forth either alone or in combination with other drugs. AD is a photosensitive drug and requires protection from light...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27818836/application-of-cerium-iv-as-an-oxidimetric-agent-for-the-determination-of-ethionamide-in-pharmaceutical-formulations
#6
Kanakapura Basavaiah, Nagib A S Qarah, Sameer A M Abdulrahman
Two simple methods are described for the determination of ethionamide (ETM) in bulk drug and tablets using cerium (IV) sulphate as the oxidimetric agent. In both methods, the sample solution is treated with a measured excess of cerium (IV) solution in H2SO4 medium, and after a fixed standing time, the residual oxidant is determined either by back titration with standard iron (II) solution to a ferroin end point in titrimetry or by reacting with o-dianisidine followed by measurement of the absorbance of the orange-red coloured product at 470 nm in spectrophotometry...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27818835/the-genus-luehea-malvaceae-tiliaceae-review-about-chemical-and-pharmacological-aspects
#7
REVIEW
João Tavares Calixto-Júnior, Selene Maia de Morais, Aracélio Viana Colares, Henrique Douglas Melo Coutinho
Popularly known as "açoita-cavalo" (whips-horse), Luehea species (Malvaceae-Tilioideae) are native to America and are used in folk medicine as anti-inflammatory, antidiarrheal, antiseptic, expectorant, and depurative and against skin infections. Although there are studies showing the chemical constituents of some species, the active substances have not been properly identified. A systematic study was carried out through a computer search of data on CAPES journals, SciELO, ISI Bireme, PubMed, ScienceDirect, ScienceDomain Medline, and Google Scholar from published articles using key words: Luehea, açoita-cavalo, and Malvaceae...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27190691/adverse-effects-of-subchronic-dose-of-aspirin-on-reproductive-profile-of-male-rats
#8
Archana Vyas, Heera Ram, Ashok Purohit, Rameshwar Jatwa
Aspirin (acetylsalicylic acid) is widely used for cardiovascular prophylaxis and as anti-inflammatory pharmaceutical. An investigation was carried out to evaluate the influence of subchronic dose of aspirin on reproductive profile of male rats, if any. Experimental animals were divided into three groups: control and aspirin subchronic dose of 12.5 mg/kg for 30 days and 60 days, respectively, while alterations in sperm dynamics, testicular histopathological and planimetric investigations, body and organs weights, lipid profiles, and hematology were performed as per aimed objectives...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27066294/physicochemical-and-antimicrobial-properties-of-cocoa-pod-husk-pectin-intended-as-a-versatile-pharmaceutical-excipient-and-nutraceutical
#9
Ofosua Adi-Dako, Kwabena Ofori-Kwakye, Samuel Frimpong Manso, Mariam El Boakye-Gyasi, Clement Sasu, Mike Pobee
The physicochemical and antimicrobial properties of cocoa pod husk (CPH) pectin intended as a versatile pharmaceutical excipient and nutraceutical were studied. Properties investigated include pH, moisture content, ash values, swelling index, viscosity, degree of esterification (DE), flow properties, SEM, FTIR, NMR, and elemental content. Antimicrobial screening and determination of MICs against test microorganisms were undertaken using agar diffusion and broth dilution methods, respectively. CPH pectin had a DE of 26...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27034908/xyloglucan-based-in-situ-gel-of-lidocaine-hcl-for-the-treatment-of-periodontosis
#10
Ashlesha P Pandit, Vaibhav V Pol, Vinit S Kulkarni
The present study was aimed at formulating thermoreversible in situ gel of local anesthetic by using xyloglucan based mucoadhesive tamarind seed polysaccharide (TSP) into periodontal pocket. Temperature-sensitive in situ gel of lidocaine hydrochloride (LH) (2% w/v) was formulated by cold method. A full 3(2) factorial design was employed to study the effect of independent variables concentrations of Lutrol F127 and TSP to optimize in situ gel. The dependent variables evaluated were gelation temperature (Y 1) and drug release (Y 2)...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27018126/pharmacological-investigation-of-the-wound-healing-activity-of-cestrum-nocturnum-l-ointment-in-wistar-albino-rats
#11
Hemant Kumar Nagar, Amit Kumar Srivastava, Rajnish Srivastava, Madan Lal Kurmi, Harinarayan Singh Chandel, Mahendra Singh Ranawat
Objectives. The present study was aimed at investigating the wound healing effect of ethanolic extract of Cestrum nocturnum (L.) leaves (EECN) using excision and incision wound model. Methods. Wistar albino rats were divided into five groups each consisting of six animals; group I (left untreated) considered as control, group II (ointment base treated) considered as negative control, group III treated with 5% (w/w) povidone iodine ointment (Intadine USP), which served as standard, group IV treated with EECN 2% (w/w) ointment, and group V treated with EECN 5% (w/w) ointment were considered as test groups...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26989562/in-vitro-and-in-vivo-correlation-of-colon-targeted-compression-coated-tablets
#12
Siddhartha Maity, Amit Kundu, Sanmoy Karmakar, Biswanath Sa
This study was performed to assess and correlate in vitro drug release with in vivo absorption of prednisolone (PDL) from a colon-targeted tablet prepared by compression coating of core tablet. In vivo drug absorption study was conducted using a high performance liquid chromatographic (HPLC) method, which was developed and validated for the estimation of PDL in rabbit plasma. The calibration curve showed linearity in the concentration range of 0.05 to 50 μg/mL with the correlation coefficient (r) of 0.999...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26981319/cellulose-acetate-398-10-asymmetric-membrane-capsules-for-osmotically-regulated-delivery-of-acyclovir
#13
Alka Sonkar, Anil Kumar, Kamla Pathak
The study was aimed at developing cellulose acetate asymmetric membrane capsules (AMCs) of acyclovir for its controlled delivery at the absorption site. The AMCs were prepared by phase inversion technique using wet process. A 2(3) full factorial design assessed the effect of independent variables (level(s) of polymer, pore former, and osmogen) on the cumulative drug release from AMCs. The buoyant optimized formulation F7 (low level of cellulose acetate; high levels of both glycerol and sodium lauryl sulphate) displayed maximum drug release of 97...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26783497/validation-of-a-uv-spectrometric-method-for-the-assay-of-tolfenamic-acid-in-organic-solvents
#14
Sofia Ahmed, Nafeesa Mustaan, Muhammad Ali Sheraz, Syeda Ayesha Ahmed Un Nabi, Iqbal Ahmad
The present study has been carried out to validate a UV spectrometric method for the assay of tolfenamic acid (TA) in organic solvents. TA is insoluble in water; therefore, a total of thirteen commonly used organic solvents have been selected in which the drug is soluble. Fresh stock solutions of TA in each solvent in a concentration of 1 × 10(-4 )M (2.62 mg%) were prepared for the assay. The method has been validated according to the guideline of International Conference on Harmonization and parameters like linearity, range, accuracy, precision, sensitivity, and robustness have been studied...
2015: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26649229/market-assessment-and-product-evaluation-of-probiotic-containing-dietary-supplements-available-in-bangladesh-market
#15
Anjuman Ara Begum, D M Jakaria, Sharif Md Anisuzzaman, Mahfuzul Islam, Siraje Arif Mahmud
Probiotics containing food supplements available in Bangladesh market were identified and collected for assessment. To assess their label claim, they were resuspended into sterile distilled water. Then, series dilutions of each sample solution were prepared and immediately plated out, in duplicate, into De Man Rogosa Sharpe (MRS) agar. These plates were then incubated at 37°C for 48 hours and colonies were counted. Viable cell numbers stated on the labels were compared with actual viable cell numbers. To assess the viability of the probiotics included in the products, probiotic strains were isolated from each of the four products and screened for inhibitory activity against six indicator strains...
2015: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26649228/surface-deposition-and-coalescence-and-coacervation-phase-separation-methods-in-vitro-study-and-compatibility-analysis-of-eudragit-rs30d-eudragit-rl30d-and-carbopol-pla-loaded-metronidazole-microspheres
#16
Irin Dewan, Md Maynul Islam, Maksud Al-Hasan, Joydeb Nath, Sefat Sultana, Md Sohel Rana
Metronidazole (MTZ) has extremely broad spectrum of protozoal and antimicrobial activity and is clinically effective in trichomoniasis, amoebic colitis, and giardiasis. This study was performed to formulate and evaluate the MTZ loaded microspheres by coacervation phase separation and surface deposition and coalescence methods using different polymers like Gelatin, Carbopol 934P, Polylactic Acid (PLA), Eudragit RS30D, and Eudragit RL30D to acquire sustained release of drug. In vitro dissolution studies were carried out in phosphate buffer (pH 7...
2015: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26634173/enhancement-of-solubility-of-lamotrigine-by-solid-dispersion-and-development-of-orally-disintegrating-tablets-using-3-2-full-factorial-design
#17
Jatinderpal Singh, Rajeev Garg, Ghanshyam Das Gupta
Present investigation deals with the preparation and evaluation of orally disintegrating tablets (ODTs) of lamotrigine using β-cyclodextrin and PVP-K30 as polymers for the preparation of solid dispersion which help in enhancement of aqueous solubility of this BCS CLASS-II drug and sodium starch glycolate (SSG) and crospovidone as a superdisintegrating agent, to reduce disintegration time. The ODTs were prepared by direct compression method. Nine formulations were developed with different ratios of superdisintegrating agents...
2015: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26556207/fda-approved-natural-polymers-for-fast-dissolving-tablets
#18
REVIEW
Md Tausif Alam, Nayyar Parvez, Pramod Kumar Sharma
Oral route is the most preferred route for administration of different drugs because it is regarded as safest, most convenient, and economical route. Fast disintegrating tablets are very popular nowadays as they get dissolved or facilely disintegrated in mouth within few seconds of administration without the need of water. The disadvantages of conventional dosage form, especially dysphagia (arduousness in swallowing), in pediatric and geriatric patients have been overcome by fast dissolving tablets. Natural materials have advantages over synthetic ones since they are chemically inert, non-toxic, less expensive, biodegradable and widely available...
2014: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26556206/preparation-and-in-vitro-evaluation-of-ethylcellulose-and-polymethacrylate-resins-loaded-microparticles-containing-hydrophilic-drug
#19
Satish Pandav, Jitendra Naik
Objective. The purpose of the recent study was to prepare and estimate sustained release of Ethylcellulose (300 cps) and Eudragit (RS 100 and RL 100) microparticles containing Propranolol hydrochloride used as a treatment of cardiovascular system, especially hypertension. Method. Propranolol hydrochloride was microencapsulated with different polymers (Ethylcellulose, Eudragit RS, and Eudragit RL) using modified hydrophobic (O/O) solvent evaporation method using 1 : 1 combination of acetone and isopropanol as the internal phase...
2014: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26556205/development-and-validation-of-liquid-chromatographic-method-for-estimation-of-naringin-in-nanoformulation
#20
Kranti P Musmade, M Trilok, Swapnil J Dengale, Krishnamurthy Bhat, M S Reddy, Prashant B Musmade, N Udupa
A simple, precise, accurate, rapid, and sensitive reverse phase high performance liquid chromatography (RP-HPLC) method with UV detection has been developed and validated for quantification of naringin (NAR) in novel pharmaceutical formulation. NAR is a polyphenolic flavonoid present in most of the citrus plants having variety of pharmacological activities. Method optimization was carried out by considering the various parameters such as effect of pH and column. The analyte was separated by employing a C18 (250...
2014: Journal of Pharmaceutics
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