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Journal of Pharmaceutics

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https://www.readbyqxmd.com/read/29130019/patients-knowledge-and-attitude-toward-the-disposal-of-medications
#1
Aeshah AlAzmi, Hani AlHamdan, Rayf Abualezz, Faiz Bahadig, Noha Abonofal, Mohamed Osman
Background: Safe disposal of medications is of high concern as malpractice may lead to harmful consequences such as undesirable effects, prescription drug abuse, overstocking, self-medication, accidental overdose, and even death. There is a lack of uniform and nationwide guidance on how patients should safely dispose their leftover medications. This study aims to assess patients' knowledge and attitude regarding the disposal of medications. Method: This research is a cross-sectional study...
2017: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28781909/evaluation-of-the-disintegrant-properties-of-native-starches-of-five-new-cassava-varieties-in-paracetamol-tablet-formulations
#2
Frank Kumah Adjei, Yaa Asantewaa Osei, Noble Kuntworbe, Kwabena Ofori-Kwakye
The disintegrant potential of native starches of five new cassava (Manihot esculenta Crantz.) varieties developed by the Crops Research Institute of Ghana (CRIG) was studied in paracetamol tablet formulations. The yield of the starches ranged from 8.0 to 26.7%. The starches were basic (pH: 8.1-9.9), with satisfactory moisture content (≤15%), swelling capacity (≥20%), ash values (<1%), flow properties, and negligible toxic metal ion content, and compatible with the drug. The tensile strength (Ts ), crushing strength (Cs ), and friability (Ft ) of tablets containing 5-10% w/w of the cassava starches were similar (p > 0...
2017: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28660092/novel-hplc-analysis-of-hydrocortisone-in-conventional-and-controlled-release-pharmaceutical-preparations
#3
Ofosua Adi-Dako, Samuel Oppong Bekoe, Kwabena Ofori-Kwakye, Enoch Appiah, Paul Peprah
An isocratic sensitive and precise reverse phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the determination and quantification of hydrocortisone in controlled-release and conventional (tablets and injections) pharmaceutical preparations. Chromatographic separation was achieved on an ODS (C18), 5 μm, 4.6 × 150 mm, with an isocratic elution using a freshly prepared mobile phase of composition methanol : water : acetic acid (60 : 30 : 10, v/v/v) at a flow rate of 1...
2017: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28660091/can-a-biodegradable-implanted-bilayered-drug-delivery-system-loaded-with-bmp-2-bmp-12-take-an-effective-role-in-the-biological-repair-process-of-bone-tendon-injuries-a-preliminary-report
#4
Baran Komur, Yener Akyuva, Numan Karaslan, Mehmet Isyar, Seyit Ali Gumustas, Ibrahim Yilmaz, Semih Akkaya, Duygu Yasar Sirin, Cagri Ata Mutlu, Ahmet Guray Batmaz, Olcay Guler, Mahir Mahirogullari
BACKGROUND: Use of biodegradable and biocompatible materials in the orthopedic surgery is gaining popularity. In this research, the rate of controlled release of a bilayered prototype biomaterial designed to promote osteoblastic and tenoblastic activity was calculated using pharmacochemical methods. METHODS: The first part of the design, composed of a sodium tetraborate, polyvinyl alcohol, and starch based hydrogel, was loaded with bone morphogenic protein-2. The second part which was composed of a sodium tetraborate, polyvinyl alcohol, and chitosan based hydrogel was loaded with bone morphogenic protein-12...
2017: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28321359/high-throughput-screening-of-potential-skin-penetration-enhancers-using-stratum-corneum-lipid-liposomes-preliminary-evaluation-for-different-concentrations-of-ethanol
#5
Pajaree Sakdiset, Yuki Kitao, Hiroaki Todo, Kenji Sugibayashi
In this study, we developed a technique for high-throughput screening (HTS) of skin penetration-enhancers using stratum corneum lipid liposomes (SCLLs). A fluorescent marker, sodium fluorescein (FL), entrapped in SCLLs was prepared to provide a preliminary evaluation of the effect of different concentrations of ethanol on the disruption effect of SCLLs, which is an alternative for skin penetration-enhancing effects. In addition, SCLLs containing a fluorescent probe (DPH, TMA-DPH, or ANS) were also prepared and utilized to investigate SCLL fluidity...
2017: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28261517/formulation-and-evaluation-of-new-glimepiride-sublingual-tablets
#6
Wafa Al-Madhagi, Ahmed Abdulbari Albarakani, Abobakr Khaled Alhag, Zakaria Ahmed Saeed, Nahlah Mansour Noman, Khaldon Mohamed
Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. The aim of this research was to introduce a new glimepiride formula for sublingual administration and rapid drug absorption that can be used in an emergency. The new sublingual formulation was prepared after five trials to prepare the suitable formulation...
2017: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28239502/immunooncology-can-the-right-chimeric-antigen-receptors-t-cell-design-be-made-to-cure-all-types-of-cancers-and-will-it-be-covered
#7
REVIEW
Regina Au
Immunooncology (IO) is the buzz word today and it has everyone doing IO research. If we look back at the history of cancer treatment, the survival rate was measured in months which, according to oncologists, was a lot back then because the mortality rate in most cancers was 100%. However, most traditional chemotherapies were not well tolerated because they would kill both cancerous and healthy cells, which lead to major side effects such as loss of hair, nausea and vomiting, and risk of infection. Survival was better but not much better depending on the type of cancer and the patient's own genetic and physiological make-up...
2017: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28191360/self-medication-pattern-among-social-science-university-students-in-northwest-ethiopia
#8
Dessalegn Asmelashe Gelayee
Background. Inappropriate self-medication causes wastage of resources among others. Method. This survey study was conducted to determine self-medication pattern of 404 social science university students in Northwest Ethiopia, who were selected through stratified random sampling technique. Data were collected using self-administered questionnaire and analyzed with SPSS version 20 statistical software. Binary Logistic Regression analysis was employed with P value < 0.05 considered statistically significant...
2017: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28182107/methanolic-extract-of-dill-leaves-inhibits-ages-formation-and-shows-potential-hepatoprotective-effects-in-ccl4-induced-liver-toxicity-in-rat
#9
Ebrahim Abbasi Oshaghi, Iraj Khodadadi, Fatemeh Mirzaei, Mozafar Khazaei, Heidar Tavilani, Mohammad Taghi Goodarzi
The research was aimed at evaluating the antiglycation, antioxidant, and hepatoprotective properties of methanolic extract of Anethum graveolens (dill). The antioxidant properties, photochemical characteristics, and antiglycation effects of dill extract were measured. Carbon tetrachloride-induced hepatotoxic rats were used to show the hepatoprotective activity of dill leaves. Different concentration of dill extract (0.032, 0.065, 0.125, 0.25, 0.5, and 1 mg/mL) showed potential antioxidant ability. The extract of dill leaves significantly reduced AGEs formation and also fructosamine and protein carbonyl levels in rats' liver...
2017: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28154771/combined-effect-of-synthetic-and-natural-polymers-in-preparation-of-cetirizine-hydrochloride-oral-disintegrating-tablets-optimization-by-central-composite-design
#10
Chandra Sekhar Patro, Prafulla Kumar Sahu
Our aim was to employ experimental design to formulate and optimize cetirizine hydrochloride oral disintegrating tablets (ODTs) by direct compression technique, using the mutual effect of synthetic croscarmellose sodium (CCS) and natural Hibiscus rosa-sinensis mucilage (HRM) as disintegrants in the formulation. Central composite design (CCD) was applied to optimize the influence of three levels each of CCS (X1) and HRM (X2) concentrations (independent variables) for investigated responses: disintegration time (DT) (Y1), % friability (F) (Y2), and % cumulative drug release (DR) (Y3) (dependent variables)...
2017: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28116221/structural-alteration-in-dermal-vessels-and-collagen-bundles-following-exposure-of-skin-wound-to-zeolite-bentonite-compound
#11
Shahram Paydar, Ali Noorafshan, Behnam Dalfardi, Shahram Jahanabadi, Seyed Mohammad Javad Mortazavi, Seyedeh-Saeedeh Yahyavi, Hadi Khoshmohabat
Background. This study examines the impact of one-time direct application of haemostatic agent zeolite-bentonite powder to wounded skin on the healing process in rats. Materials and Methods. 24 male Sprague-Dawley rats were randomly allocated into two groups (n = 12): (1) the rats whose wounds were washed only with sterile normal saline (NS-treated) and (2) those treated with zeolite-bentonite compound (ZEO-treated). The wound was circular, full-thickness, and 2 cm in diameter. At the end of the 12th day, six animals from each group were randomly selected and terminated...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28058133/quantification-of-warfarin-in-dried-rat-plasma-spots-by-high-performance-liquid-chromatography-with-tandem-mass-spectrometry
#12
Alexander Chernonosov
This paper presents the development and validation of a novel method for quantification of the oral anticoagulant drug warfarin in dried plasma spots (DPS) by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). Blood plasma was chosen as a biological fluid to preclude the influence of the hematocrit on the results of the analysis. A 30 μL sample of rat plasma was placed onto Whatman 903 Protein Saver Card and was allowed to dry. A single DPS is sufficient for preparing eight 3...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28044122/ingestibility-and-formulation-quality-of-lansoprazole-orally-disintegrating-tablets
#13
Sumio Chono, Megumi Matsui, Katsuki Nakamura, Ryoya Kasai
Objectives. We evaluated the ingestibility and formulation quality of one branded (formulation A) and five generic (formulations B, C, D, E, and F) lansoprazole orally disintegrating (OD) tablets. Methods. Ingestibility, including the oral disintegrating time, taste, mouth feeling, and palatability, was examined by sensory testing in healthy subjects. Formulation qualities, including salivary stability, gastric acid resistance, and intestinal dissolution behavior, were examined. Results and Discussion. The oral disintegration time of formulation F (52 s) was significantly longer than that of other formulations (32-37 s)...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28042494/freeze-dried-quetiapine-nicotinamide-binary-solid-dispersions-a-new-strategy-for-improving-physicochemical-properties-and-ex-vivo-diffusion
#14
Ahmed Mahmoud Abdelhaleem Ali, Mayyas Mohammad Ahmad Al-Remawi
Improving the physicochemical properties and oral bioavailability of quetiapine fumarate (QF) enabling enhanced antipsychotic attributes are the main aims of this research. The freeze dried solid dispersion strategy was adopted using nicotinamide (NIC) as highly soluble coformer. The prepared dispersions were characterized using scanning electron microscopy (SEM) differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). Static disc intrinsic dissolution rate and ex vivo diffusion through intestinal tissues were conducted and compared to pure quetiapine fumarate...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28018705/antioxidant-and-antibacterial-potential-of-silver-nanoparticles-biogenic-synthesis-utilizing-apple-extract
#15
Upendra Nagaich, Neha Gulati, Swati Chauhan
The advancement of the biological production of nanoparticles using herbal extracts performs a significant role in nanotechnology discipline as it is green and does not engage harsh chemicals. The objective of the present investigation was to extract flavonoids in the mode of apple extract and synthesize its silver nanoparticles and ultimately nanoparticles loading into hydrogels. The presence of flavonoids in apple extract was characterized by preliminary testing like dil. ammonia test and confirmatory test by magnesium ribbon test...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27999707/novel-concepts-for-drug-hypersensitivity-based-on-the-use-of-long-time-scale-molecular-dynamic-simulation
#16
Takahiro Murai, Norihito Kawashita, Yu-Shi Tian, Tatsuya Takagi
The discovery that several drug hypersensitivity reactions (DHRs) are associated with specific human leukocyte antigen (HLA) alleles has attracted increasing research interest. However, the underlying mechanisms of these HLA-induced DHRs remain unclear, especially for drug-induced immediate activation of T-cell clones (TCCs). Recently, a novel hypothesis involving partial detachment between self-peptide(s) and the HLA molecule (altered peptide-HLA (pHLA) model) has been proposed to explain these phenomena. In order to clarify this hypothesis, we performed long-timescale molecular dynamics (MD) simulations...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27885353/a-comparison-of-the-effects-of-alpha-and-medical-grade-honey-ointments-on-cutaneous-wound-healing-in-rats
#17
Shahram Paydar, Majid Akrami, Amirreza Dehghanian, Roshanak Alavi Moghadam, Mohsen Heidarpour, Amir Bahari Khoob, Behnam Dalfardi
Introduction. This study compared the healing efficacy and possible adverse effects of topical Alpha and medical-grade honey ointments on cutaneous wounds in rats. Methods. To conduct the study, 22 male Sprague-Dawley rats were randomly allocated into two equal groups: (1) rats with Alpha ointment applied to the wound surface area and (2) rats with medical-grade honey ointment applied to their wounds. The ointments were applied daily during the 21-day study period. Wound contraction was examined photographically with images taken on days 0, 7, and 21 after wounding...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27885352/formulation-and-evaluation-of-antibacterial-creams-and-gels-containing-metal-ions-for-topical-application
#18
Mei X Chen, Kenneth S Alexander, Gabriella Baki
Background. Skin infections occur commonly and often present therapeutic challenges to practitioners due to the growing concerns regarding multidrug-resistant bacterial, viral, and fungal strains. The antimicrobial properties of zinc sulfate and copper sulfate are well known and have been investigated for many years. However, the synergistic activity between these two metal ions as antimicrobial ingredients has not been evaluated in topical formulations. Objective. The aims of the present study were to (1) formulate topical creams and gels containing zinc and copper alone or in combination and (2) evaluate the in vitro antibacterial activity of these metal ions in the formulations...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27872792/porcine-pancreatic-lipase-inhibitory-agent-isolated-from-medicinal-herb-and-inhibition-kinetics-of-extracts-from-eleusine-indica-l-gaertner
#19
Siew Ling Ong, Siau Hui Mah, How Yee Lai
Eleusine indica (Linnaeus) Gaertner is a traditional herb known to be depurative, febrifuge, and diuretic and has been reported with the highest inhibitory activity against porcine pancreatic lipase (PPL) among thirty two plants screened in an earlier study. This study aims to isolate and identify the active components that may possess high potential as an antiobesity agent. Of the screened solvent fractions of E. indica, hexane fraction showed the highest inhibitory activity of 27.01 ± 5.68% at 100 μg/mL...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27847674/functional-performance-of-chitosan-carbopol-974p-nf-matrices-in-captopril-tablets
#20
Yuritze Alejandra Aguilar-López, Leopoldo Villafuerte-Robles
Chitosan and Carbopol have been used to form a complex through an electrostatic interaction between the protonated amine (NH3(+)) group of chitosan and the carboxylate (COO(-)) group of Carbopol. In situ polyelectrolyte complexes formations based on the physical mixture of chitosan and sodium alginate were found and could be used as an oral controlled release matrix. The aim of this work is the assessment of a possible interaction between the particles of chitosan and Carbopol 974P NF that could modify their technological performance in captopril tablets...
2016: Journal of Pharmaceutics
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