Baran Komur, Yener Akyuva, Numan Karaslan, Mehmet Isyar, Seyit Ali Gumustas, Ibrahim Yilmaz, Semih Akkaya, Duygu Yasar Sirin, Cagri Ata Mutlu, Ahmet Guray Batmaz, Olcay Guler, Mahir Mahirogullari
BACKGROUND: Use of biodegradable and biocompatible materials in the orthopedic surgery is gaining popularity. In this research, the rate of controlled release of a bilayered prototype biomaterial designed to promote osteoblastic and tenoblastic activity was calculated using pharmacochemical methods. METHODS: The first part of the design, composed of a sodium tetraborate, polyvinyl alcohol, and starch based hydrogel, was loaded with bone morphogenic protein-2. The second part which was composed of a sodium tetraborate, polyvinyl alcohol, and chitosan based hydrogel was loaded with bone morphogenic protein-12...
2017: Journal of Pharmaceutics