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Health Security

Glendon Diehl, Nicole Bradstreet, Felicia Monahan
Tasked with analyzing the effectiveness of the Department of Defense's (DoD's) global health engagements, the Uniformed Services University of the Health Sciences (USU) used the Measures Of Effectiveness in Defense Engagement and Learning (MODEL) study to conduct a qualitative analysis of the DoD's response efforts to the Ebola pandemic in West Africa. The research aims to summarize the findings of studies that monitor and evaluate the DoD's response to the Ebola pandemic or compare the effectiveness of different DoD response activities; it further aims to identify common themes around positive and negative lessons learned and recommendations that can be applied to future DoD humanitarian assistance and disaster response efforts...
September 2016: Health Security
Jason G Ramage, Kristin W Prentice, Lindsay DePalma, Kodumudi S Venkateswaran, Sruti Chivukula, Carol Chapman, Melissa Bell, Shomik Datta, Ajay Singh, Alex Hoffmaster, Jawad Sarwar, Nishanth Parameswaran, Mrinmayi Joshi, Nagarajan Thirunavkkarasu, Viswanathan Krishnan, Stephen Morse, Julie R Avila, Shashi Sharma, Peter L Estacio, Larry Stanker, David R Hodge, Segaran P Pillai
We conducted a comprehensive, multiphase laboratory evaluation of the Anthrax BioThreat Alert(®) test strip, a lateral flow immunoassay (LFA) for the rapid detection of Bacillus anthracis spores. The study, conducted at 2 sites, evaluated this assay for the detection of spores from the Ames and Sterne strains of B. anthracis, as well as those from an additional 22 strains. Phylogenetic near neighbors, environmental background organisms, white powders, and environmental samples were also tested. The Anthrax LFA demonstrated a limit of detection of about 10(6) spores/mL (ca...
September 2016: Health Security
Tom Inglesby
No abstract text is available yet for this article.
September 2016: Health Security
Sarah Bauerle Bass, Thomas F Gordon, Laurie Maurer, Judith Greener, Gabriella Mora, Dominique Ruggieri, Caitlin Wolak, Claudia Parvanta
Potential terror events such as "dirty bombs" could have significant public health effects, but little is known about how low-literacy populations perceive dirty bombs, their trust in public health or government officials to provide credible information, and their willingness to comply with recommended actions. We surveyed 50 low-literacy adults from a large urban center; they were mostly members of ethnic minority groups. We used unique social marketing methods-perceptual mapping and vector message modeling-to create 3-dimensional models that reflected respondents' knowledge of what a dirty bomb is, their intended behaviors should one occur, and their concerns about complying with "shelter in place" recommendations...
September 2016: Health Security
Scott Santibañez, Philip M Polgreen, Susan E Beekmann, Mark E Rupp, Carlos Del Rio
On September 30, 2014, the first US patient with Ebola virus disease was diagnosed. Hospitals and healthcare systems identified many complex issues that needed to be addressed to prepare for possible future outbreaks. Here we summarize themes identified in free text responses from a query of infectious disease physicians from the Infectious Disease Society of America's (IDSA) Emerging Infections Network (EIN) early in the domestic Ebola response and place them into the context of biopreparedness for possible future events...
September 2016: Health Security
Crystal Boddie, Matthew Watson, Tara Kirk Sell
This latest article in the Federal Funding for Health Security series assesses FY2017 US government funding in 5 domains critical to strengthening health security: biosecurity, radiological and nuclear security, chemical security, pandemic influenza and emerging infectious disease, and multiple-hazard and general preparedness.
September 2016: Health Security
Leonard A Cole
The United States and the United Kingdom ended outdoor biological warfare testing in populated areas nearly half a century ago. Yet, the conduct, health effects, and propriety of those tests remain controversial. The varied views reflect the limits of currently available test information and evolving societal values on research involving human subjects. Western political culture has changed since the early days of the American and British testing programs. People have become less reluctant to question authority, and institutional review boards must now pre-approve research involving human subjects...
September 2016: Health Security
Frank L Smith
Malicious software and infectious diseases are similar is several respects, as are the functional requirements for surveillance and intelligence to defend against these threats. Given these similarities, this article compares and contrasts the actors, relationships, and norms at work in cyber intelligence and disease surveillance. Historical analysis reveals that civilian cyber defense is more decentralized, private, and voluntary than public health in the United States. Most of these differences are due to political choices rather than technical necessities...
September 2016: Health Security
Kenneth B Yeh, Martin Adams, Paul D Stamper, Debanjana Dasgupta, Roger Hewson, Charles D Buck, Allen L Richards, John Hay
Strategic laboratory planning in limited resource areas is essential for addressing global health security issues. Establishing a national reference laboratory, especially one with BSL-3 or -4 biocontainment facilities, requires a heavy investment of resources, a multisectoral approach, and commitments from multiple stakeholders. We make the case for donor organizations and recipient partners to develop a comprehensive laboratory operations roadmap that addresses factors such as mission and roles, engaging national and political support, securing financial support, defining stakeholder involvement, fostering partnerships, and building trust...
September 2016: Health Security
Leremy A Colf, Reginald Brothers, Christina E Murata
The Department of Homeland Security's (DHS) Science and Technology (S&T) Directorate plays a role in public health that extends beyond biodefense. These responsibilities were exercised as part of the 2014-16 Ebola outbreak, leading to productive and beneficial contributions to the international public health response and improved operations in the United States. However, we and others have identified numerous areas for improvement. Based on our successes and lessons learned, we propose a number of ways that DHS, the interagency, and academia can act now to ensure improved responses to future public health crises...
July 2016: Health Security
Antonio Candeliere, Emanuele Campese, Adelia Donatiello, Stefania Pagano, Michela Iatarola, Francesco Tolve, Leonardo Antonino, Antonio Fasanella
The use of products that can neutralize or significantly reduce the microbial load and that are not harmful to human health and the environment represents a milestone in the fight against the spread of infectious diseases. Peracetic acid, besides being an excellent sterilizing and sporicidal agent, is harmless to humans and the environment when it is used in a common dosage. However, the high costs and loss of efficacy of the product very quickly after its reconstitution limit its use. We evaluated the efficacy and stability of 2 commercial products, based on stabilized peracetic acid (Pathoster(®) 0...
July 2016: Health Security
Edwardina Otieno Ndhine, Hans-Christian Slotved, Eric Mogaka Osoro, Katja N Olsen, Moses Rugutt, Cathryn W Wanjohi, Walter Mwanda, Benson Mburu Kinyagia, Nina R Steenhard, John-Erik Stig Hansen
A biosecurity survey was performed to gather information on the biosecurity level and laboratory capacity in Kenya for the purpose of providing information outlining relevant components for biosecurity legislation, biosecurity implementation, and enforcement of biosecurity measures in Kenya. This survey is, to the authors' knowledge, the first to be published from an African country. A total of 86 facilities with laboratories covering relevant categories, such as training laboratories, human diagnostic laboratories, veterinary diagnostic laboratories, and research laboratories, were selected to participate in the survey...
July 2016: Health Security
Shobha S Subhash, Gio Baracco, Shelly L Miller, Aaron Eagan, Lewis J Radonovich
We estimated the number of isolation beds needed to care for a surge in patients during an airborne-transmissible influenza pandemic. Based on US health system data, the amount of available airborne isolation beds needed for ill patients will be exceeded early in the course of a moderate or severe influenza pandemic, requiring medical facilities to find ways to further expand isolation bed capacity. Rather than building large numbers of permanent airborne infection isolation rooms to increase surge capacity, an investment that would come at great financial cost, it may be more prudent to prepare for wide-scale creation of just-in-time temporary negative-pressure wards...
July 2016: Health Security
Jason Paragas, Joe Dudley, William Karesh, Terry Leighton, Alan Rudolph
No abstract text is available yet for this article.
July 2016: Health Security
Sarah Power, Charles Symons, Holly Carter, Emma Jones, Richard Amlôt, Joanne Larner, Hazem Matar, Robert P Chilcott
Mass casualty decontamination is a public health intervention that would be employed by emergency responders following a chemical, biological, or radiological incident. The decontamination of large numbers of casualties is currently most often performed with water to remove contaminants from the skin surface. An online survey was conducted to explore US fire departments' decontamination practices and their preparedness for responding to incidents involving mass casualty decontamination. Survey respondents were asked to provide details of various aspects of their decontamination procedures, including expected response times to reach casualties, disrobing procedures, approaches to decontamination, characteristics of the decontamination showering process, provision for special populations, and any actions taken following decontamination...
July 2016: Health Security
Chelsea Wright Thompson, Lindsey Holmstrom, Keith Biggers, James Wall, Tammy Beckham, Matthew Coats, John Korslund, Michelle M Colby
The ability to rapidly detect and report infectious diseases of domestic animals and wildlife is paramount to reducing the size and duration of an outbreak. There is currently a need in the United States livestock industry for a centralized animal disease surveillance platform, capable of collecting, integrating, and analyzing multiple data streams with dissemination to end-users. Such a system would be disease agnostic and establish baseline information on animal health and disease prevalence; it would alert health officials to anomalies potentially indicative of emerging and/or transboundary disease outbreaks, changes in the status of endemic disease, or detection of other causative agents (eg, toxins)...
July 2016: Health Security
Sadia Shakoor, Humaira Shafaq, Rumina Hasan, Shahida M Qureshi, Maqboola Dojki, Molly A Hughes, Anita K M Zaidi, Erum Khan
The primary goal of biosafety education is to ensure safe practices among workers in biomedical laboratories. Despite several educational workshops by the Pakistan Biological Safety Association (PBSA), compliance with safe practices among laboratory workers remains low. To determine barriers to implementation of recommended biosafety practices among biomedical laboratory workers in Pakistan, we conducted a questionnaire-based survey of participants attending 2 workshops focusing on biosafety practices in Karachi and Lahore in February 2015...
July 2016: Health Security
James C Liljegren, David F Brown, Melissa M Lunden, David Silcott
Following the release of an aerosolized biological agent in a transit venue, material deposited on waiting passengers and subsequently shed from their clothing may significantly magnify the scope and consequences of such an attack. Published estimates of the relevant particle deposition and resuspension parameters for complex indoor environments such as a transit facility are nonexistent. In this study, measurements of particle deposition velocity onto cotton fabric samples affixed to stationary and walking people in a large multimodal transit facility were obtained for tracer particle releases carried out as part of a larger study of subway airflows and particulate transport...
July 2016: Health Security
Mehmet Doganay, Hayati Demiraslan
After the Arab Spring uprising, Syria descended into a civil war in 2011. By March 2016, the United Nations reported that 13.5 million Syrians required humanitarian assistance, including 6.6 million internally displaced persons and more than 4.8 million refugees outside of Syria. Turkey is currently hosting the largest number of Syrian refugees-more than 2.7 million. A limited number of refugees are living in camps settled around the border, and others are spread throughout Turkey. This explosive and unexpected increase in the Syrian population in Turkey has had several negative impacts on health and social determinants...
July 2016: Health Security
Stephan Velsko, Thomas Bates
Despite numerous calls for improvement, the US biosurveillance enterprise remains a patchwork of uncoordinated systems that fail to take advantage of the rapid progress in information processing, communication, and analytics made in the past decade. By synthesizing components from the extensive biosurveillance literature, we propose a conceptual framework for a national biosurveillance architecture and provide suggestions for implementation. The framework differs from the current federal biosurveillance development pathway in that it is not focused on systems useful for "situational awareness" but is instead focused on the long-term goal of having true warning capabilities...
May 2016: Health Security
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