Weidong Wu, Youjun Liu, Renfeng Liu, Yuhao Wang, Yuqi Zhao, Hui Li, Botao Lu, Cheng Ju, Xinlin Gao, Hailiang Xu, Yulin Cao, Shixiang Cheng, Zhiyuan Wang, Shuaijun Jia, Chunping Hu, Lei Zhu, Dingjun Hao
The intricate electrophysiological functions and anatomical structures of spinal cord tissue render the establishment of in vitro models for spinal cord-related diseases highly challenging. Currently, both in vivo and in vitro models for spinal cord-related diseases are still underdeveloped, complicating the exploration and development of effective therapeutic drugs or strategies. Organoids cultured from human induced pluripotent stem cells (hiPSCs) hold promise as suitable in vitro models for spinal cord-related diseases...
April 1, 2024: ACS Biomaterials Science & Engineering