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ACS Biomaterials Science & Engineering

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https://www.readbyqxmd.com/read/28920077/mimicking-the-bioactivity-of-fibroblast-growth-factor-2-using-supramolecular-nanoribbons
#1
Charles M Rubert Pérez, Zaida Álvarez, Feng Chen, Taner Aytun, Samuel I Stupp
Fibroblast growth factor (FGF-2) is a multifunctional growth factor that has pleiotropic effects in different tissues and organs. In particular, FGF-2 has a special role in angiogenesis, an important process in development, wound healing, cell survival, and differentiation. Therefore, incorporating biological agents like FGF-2 within therapeutic biomaterials is a potential strategy to create angiogenic bioactivity for the repair of damaged tissue caused by trauma or complications that arise from age and/or disease...
September 11, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28824959/predehydration-and-ice-seeding-in-the-presence-of-trehalose-enable-cell-cryopreservation
#2
Haishui Huang, Gang Zhao, Yuntian Zhang, Jiangsheng Xu, Thomas L Toth, Xiaoming He
Conventional approaches for cell cryopreservation require the use of toxic membrane-penetrating cryoprotective agents (pCPA), which limits the clinical application of cryopreserved cells. Here, we show intentionally induced ice formation at a high subzero temperature (> -10 °C) during cryopreservation, which is often referred to as ice seeding, could result in significant cell injury in the absence of any pCPA. This issue can be mitigated by predehydrating cells using extracellular trehalose to their minimal volume with minimized osmotically active water before ice seeding...
August 14, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28824958/confined-sandwichlike-microenvironments-tune-myogenic-differentiation
#3
José Ballester-Beltrán, Sara Trujillo, Enateri V Alakpa, Vicente Compañ, Rafael Gavara, Dominic Meek, Christopher C West, Bruno Péault, Matthew J Dalby, Manuel Salmerón-Sánchez
Sandwichlike (SW) cultures are engineered as a multilayer technology to simultaneously stimulate dorsal and ventral cell receptors, seeking to mimic cell adhesion in three-dimensional (3D) environments in a reductionist manner. The effect of this environment on cell differentiation was investigated for several cell types cultured in standard growth media, which promotes proliferation on two-dimensional (2D) surfaces and avoids any preferential differentiation. First, murine C2C12 myoblasts showed specific myogenic differentiation...
August 14, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28317023/reduction-of-thrombosis-and-bacterial-infection-via-controlled-nitric-oxide-no-release-from-s-nitroso-n-acetylpenicillamine-snap-impregnated-carbosil-intravascular-catheters
#4
Yaqi Wo, Elizabeth J Brisbois, Jianfeng Wu, Zi Li, Terry C Major, Azmath Mohammed, Xianglong Wang, Alessandro Colletta, Joseph L Bull, Adam J Matzger, Chuanwu Xi, Robert H Bartlett, Mark E Meyerhoff
Nitric oxide (NO) has many important physiological functions, including its ability to inhibit platelet activation and serve as potent antimicrobial agent. The multiple roles of NO in vivo have led to great interest in the development of biomaterials that can deliver NO for specific biomedical applications. Herein, we report a simple solvent impregnation technique to incorporate a nontoxic NO donor, S-nitroso-N-acetylpenicillamine (SNAP), into a more biocompatible biomedical grade polymer, CarboSil 20 80A. The resulting polymer-crystal composite material yields a very stable, long-term NO release biomaterial...
March 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28317022/water-dispersible-silica-coated-upconverting-liposomes-can-a-thin-silica-layer-protect-tta-uc-against-oxygen-quenching
#5
Sven H C Askes, Vincent C Leeuwenburgh, Wim Pomp, Hadi Arjmandi-Tash, Stefania Tanase, Thomas Schmidt, Sylvestre Bonnet
Light upconversion by triplet-triplet annihilation (TTA-UC) in nanoparticles has received considerable attention for bioimaging and light activation of prodrugs. However, the mechanism of TTA-UC is inherently sensitive for quenching by molecular oxygen. A potential oxygen protection strategy is the coating of TTA-UC nanoparticles with a layer of oxygen-impermeable material. In this work, we explore if (organo)silica can fulfill this protecting role. Three synthesis routes are described for preparing water-dispersible (organo)silica-coated red-to-blue upconverting liposomes...
March 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28936479/surface-coating-of-nanoparticles-reduces-background-inflammatory-activity-while-increasing-particle-uptake-and-delivery
#6
Brittany A Moser, Rachel C Steinhardt, Aaron P Esser-Kahn
In the study of host-pathogen interactions, vaccines and drug delivery, particulate delivery system are widely used to mimic pathogen size, pattern recognition receptor agonist presentation, and target cells or organs. However, some of the polymeric systems used in particulate delivery have inherent inflammatory properties that are variable and nonspecific. These properties enhance their adjuvant activity, but confound the analysis of signaling mechanisms. Here, we present a method for particle coating with minimal background immune activation via passivation of the surface with silica-silane...
February 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28286864/in-vivo-expansion-of-melanoma-specific-t-cells-using-microneedle-arrays-coated-with-immune-polyelectrolyte-multilayers
#7
Qin Zeng, Joshua M Gammon, Lisa H Tostanoski, Yu-Chieh Chiu, Christopher M Jewell
Microneedles (MNs) are micron-scale polymeric or metallic structures that offer distinct advantages for vaccines by efficiently targeting skin-resident immune cells, eliminating injection-associated pain, and improving patient compliance. These advantages, along with recent studies showing therapeutic benefits achieved using traditional intradermal injections in human cancer patients, suggest MN delivery might enhance cancer vaccines and immunotherapies. We recently developed a new class of polyelectrolyte multilayers based on the self-assembly of model peptide antigens and molecular toll-like receptor agonists (TLRa) into ultrathin, conformal coatings...
February 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27990488/enhanced-human-induced-pluripotent-stem-cell-derived-cardiomyocyte-maturation-using-a-dual-microgradient-substrate
#8
E Huethorst, M Hortigon, V Zamora-Rodriguez, P M Reynolds, F Burton, G Smith, N Gadegaard
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) raise many possibilities for cardiac research but they exhibit an immature phenotype, which influences experimental outcomes. The aim of our research is to investigate the effects of a topographical gradient substrate on the morphology and function of commercially available hiPSC-CM. The lateral dimensions the microgrooves on the substrate varied from 8 to 100 μm space between the 8 μm grooves on one axis and from ∼5 nm to ∼1 μm in depth on the other axis...
December 12, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27990487/tuning-hydrogel-properties-to-promote-the-assembly-of-salivary-gland-spheroids-in-3d
#9
Tugba Ozdemir, Eric W Fowler, Shuang Liu, Daniel A Harrington, Robert L Witt, Mary C Farach-Carson, Swati Pradhan-Bhatt, Xinqiao Jia
Current treatments for chronic xerostomia, or "dry mouth", do not offer long-term therapeutic benefits for head and neck cancer survivors previously treated with curative radiation. Towards the goal of creating tissue-engineered constructs for the restoration of salivary gland functions, we developed new hyaluronic acid (HA)-based hydrogels using thiolated HA (HA-SH) and acrylated HA (HA-AES) with a significant molecular weight mismatch. Four hydrogel formulations with varying HA concentration, (1-2.4 wt%) and thiol/acrylate ratios (2/1 to 36/1) and elastic moduli (G': 35 to 1897 Pa, 2 h post-mixing) were investigated...
December 12, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28649641/multifunctional-poly-amine-co-ester-co-ortho-ester-for-efficient-and-safe-gene-delivery
#10
Junwei Zhang, Jiajia Cui, Yang Deng, Zhaozhong Jiang, W Mark Saltzman
Cationic polymers are used for non-viral gene delivery, but current materials lack the functionality to address the multiple barriers involved in gene delivery. Here we describe the rational design and synthesis of a new family of quaterpolymers with unprecedented multifunctionality: acid sensitivity, low cationic charge, high hydrophobicity, and biodegradability, all of which are essential for efficient and safe gene delivery. The polymers were synthesized via lipase-catalyzed polymerization of ortho ester diester, lactone, dialkyl diester, and amino diol monomers...
November 14, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28251176/bioprinting-the-cancer-microenvironment
#11
Yu Shrike Zhang, Margaux Duchamp, Rahmi Oklu, Leif W Ellisen, Robert Langer, Ali Khademhosseini
Cancer is intrinsically complex, comprising both heterogeneous cellular compositions and microenvironmental cues. During the various stages of cancer initiation, development, and metastasis, cell-cell interactions (involving vascular and immune cells besides cancerous cells) as well as cell-extracellular matrix (ECM) interactions (e.g., alteration in stiffness and composition of the surrounding matrix) play major roles. Conventional cancer models both two- and three-dimensional (2D and 3D) present numerous limitations as they lack good vascularization and cannot mimic the complexity of tumors, thereby restricting their use as biomimetic models for applications such as drug screening and fundamental cancer biology studies...
October 10, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28025653/designing-biomaterials-for-3d-printing
#12
Murat Guvendiren, Joseph Molde, Rosane M D Soares, Joachim Kohn
Three-dimensional (3D) printing is becoming an increasingly common technique to fabricate scaffolds and devices for tissue engineering applications. This is due to the potential of 3D printing to provide patient-specific designs, high structural complexity, rapid on-demand fabrication at a low-cost. One of the major bottlenecks that limits the widespread acceptance of 3D printing in biomanufacturing is the lack of diversity in "biomaterial inks". Printability of a biomaterial is determined by the printing technique...
October 10, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27942578/three-dimensional-printing-of-bone-extracellular-matrix-for-craniofacial-regeneration
#13
Ben P Hung, Bilal A Naved, Ethan L Nyberg, Miguel Dias, Christina A Holmes, Jennifer H Elisseeff, Amir H Dorafshar, Warren L Grayson
Tissue-engineered approaches to regenerate bone in the craniomaxillofacial region utilize biomaterial scaffolds to provide structural and biological cues to stem cells to stimulate osteogenic differentiation. Bioactive scaffolds are typically comprised of natural components but often lack the manufacturability of synthetic materials. To circumvent this trade-off, we 3D printed materials comprised of decellularized bone (DCB) matrix particles combined with polycaprolactone (PCL) to create novel hybrid DCB:PCL scaffolds for bone regeneration...
October 10, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27747289/3d-printing-pdms-elastomer-in-a-hydrophilic-support-bath-via-freeform-reversible-embedding
#14
Thomas J Hinton, Andrew Hudson, Kira Pusch, Andrew Lee, Adam W Feinberg
Polydimethylsiloxane (PDMS) elastomer is used in a wide range of biomaterial applications including microfluidics, cell culture substrates, flexible electronics, and medical devices. However, it has proved challenging to 3D print PDMS in complex structures due to its low elastic modulus and need for support during the printing process. Here we demonstrate the 3D printing of hydrophobic PDMS prepolymer resins within a hydrophilic Carbopol gel support via freeform reversible embedding (FRE). In the FRE printing process, the Carbopol support acts as a Bingham plastic that yields and fluidizes when the syringe tip of the 3D printer moves through it, but acts as a solid for the PDMS extruded within it...
October 10, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28286863/increase-in-dye-dendrimer-ratio-decreases-cellular-uptake-of-neutral-dendrimers-in-raw-cells
#15
Sriram Vaidyanathan, Milan Kaushik, Casey Dougherty, Rahul Rattan, Sascha N Goonewardena, Mark M Banaszak Holl, Janet Monano, Stassi DiMaggio
Neutral generation 3 poly(amidoamine) dendrimers were labeled with Oregon Green 488 (G3-OGn) to obtain materials with controlled fluorophore:dendrimer ratios (n = 1-2), a mixture containing mostly 3 dyes per dendrimer, a mixture containing primarily 4 or more dyes per dendrimer (n = 4+), and a stochastic mixture (n = 4avg). The UV absorbance of the dye conjugates increased linearly as n increased and the fluorescence emission decreased linearly as n increased. Cellular uptake was studied in RAW cells and HEK 293A cells as a function of the fluorophore:dendrimer ratio (n)...
September 12, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27660819/transport-of-nitric-oxide-no-in-various-biomedical-grade-polyurethanes-measurements-and-modeling-impact-on-no-release-properties-of-medical-devices
#16
Hang Ren, Joseph L Bull, Mark E Meyerhoff
Nitric oxide (NO) releasing polymers are promising in improving the biocompatibility of medical devices. Polyurethanes are commonly used to prepare/fabricate many devices (e.g., catheters); however, the transport properties of NO within different polyurethanes are less studied, creating a gap in the rational design of new NO releasing devices involving polyurethane materials. Herein, we study the diffusion and partitioning of NO in different biomedical polyurethanes via the time-lag method. The diffusion of NO is positively correlated with the PDMS content within the polyurethanes, which can be rationalized by effective media theory considering various microphase morphologies...
September 12, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27660818/electrochemically-modulated-nitric-oxide-release-from-flexible-silicone-rubber-patch-antimicrobial-activity-for-potential-wound-healing-applications
#17
Woong Hee Lee, Hang Ren, Jianfeng Wu, Ondrej Novak, Richard B Brown, Chuanwu Xi, Mark E Meyerhoff
Herein, we report a novel design and the antimicrobial efficacy of a flexible nitric oxide (NO) releasing patch for potential wound healing applications. The compact sized polydimethylsiloxane (PDMS) planar patch generates NO via electrochemical reduction of nitrite ions mediated by a copper(II)-ligand catalyst using a portable power system and an internal gold coated stainless steel mesh working electrode. Patches are fabricated via soft lithography and 3-D printing. The devices can continuously release NO over 4 days and exhibit potent bactericidal effects on both Escherichia coli and Staphylococcus aureus...
September 12, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28164151/graphene-foam-as-a-three-dimensional-platform-for-myotube-growth
#18
Eric Krueger, A Nicole Chang, Dale Brown, Josh Eixenberger, Raquel Brown, Sepideh Rastegar, Katie M Yocham, Kurtis D Cantley, David Estrada
This study demonstrates the growth and differentiation of C2C12 myoblasts into functional myotubes on 3-dimensional graphene foam bioscaffolds. Specifically, we establish both bare and laminin coated graphene foam as a biocompatible platform for muscle cells and identify that electrical coupling stimulates cell activity. Cell differentiation and functionality is determined by the expression of myotube heavy chain protein and Ca(2+) fluorescence, respectively. Further, our data show that the application of a pulsed electrical stimulus to the graphene foam initiates myotube contraction and subsequent localized substrate movement of over 100 micrometers...
August 8, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28626793/acidic-ph-targeted-chitosan-capped-mesoporous-silica-coated-gold-nanorods-facilitate-detection-of-pancreatic-tumors-via-multispectral-optoacoustic-tomography
#19
Matthew R Zeiderman, Desiree E Morgan, John D Christein, William E Grizzle, Kelly M McMasters, Lacey R McNally
We present a cancer nanomedicine based on acidic pH targeted gold nanorods designed for multispectral optoacoustic tomography (MSOT). We have designed gold nanorods coated with mesoporous silica and subsequently capped with chitosan (CMGs). We have conjugated pH-sensitive variant 7 pHLIP peptide to the CMGs (V7-CMG) to provide targeting specificity to the acidic tumor microenvironment. In vitro, treatment of S2VP10 and MiaPaca2 cells with V7-CMG containing gemcitabine resulted in significantly greater cytotoxicity with 97% and 96...
July 11, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28804756/assembly-of-layered-monetite-chitosan-nanocomposite-and-its-transition-to-organized-hydroxyapatite
#20
Qichao Ruan, David Liberman, Yuzheng Zhang, Dongni Ren, Yunpeng Zhang, Steven Nutt, Janet Moradian-Oldak
Bioinspired synthesis of hierarchically structured calcium phosphate (CaP) material is a highly promising strategy for developing improved bone substitute materials. However, synthesis of CaP materials with outstanding mechanical properties still remains an ongoing challenge. Inspired by the formation of lamellar structure in nacre, we designed an organic matrix composed of chitosan and cis-butenediolic acid (maleic acid, MAc) that could assemble into a layered complex and further guide the mineralization of monetite crystals, resulting in the formation of organized and parallel arrays of monetite platelets with a brick-and-mortar structure...
June 13, 2016: ACS Biomaterials Science & Engineering
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