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ACS Biomaterials Science & Engineering

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https://www.readbyqxmd.com/read/29862317/engineered-coatings-for-titanium-implants-to-present-ultralow-doses-of-bmp-7
#1
Mohammed Al-Jarsha, Vladimíra Moulisová, Aldo Leal-Egaña, Andrew Connell, Kurt B Naudi, Ashraf F Ayoub, Matthew J Dalby, Manuel Salmerón-Sánchez
The ongoing research to improve the clinical outcome of titanium implants has resulted in the implemetation of multiple approches to deliver osteogenic growth factors accelerating and sustaining osseointegration. Here we show the presentation of human bone morphogenetic protein 7 (BMP-7) adsorbed to titanium discs coated with poly(ethyl acrylate) (PEA). We have previously shown that PEA promotes fibronectin organization into nanonetworks exposing integrin- and growth-factor-binding domains, allowing a synergistic interaction at the integrin/growth factor receptor level...
May 14, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29911181/silk-based-aqueous-microcontact-printing
#2
Baskaran Ganesh Kumar, Rustamzhon Melikov, Mohammad Mohammadi Aria, Aybike Ural Yalcin, Efe Begar, Sadra Sadeghi, Kaan Guven, Sedat Nizamoglu
Lithography, the transfer of patterns to a film or substrate, is the basis by which many modern technological devices and components are produced. However, established lithographic approaches generally use complex techniques, expensive equipment, and advanced materials. Here, we introduce a water-based microcontact printing method using silk that is simple, inexpensive, ecofriendly, and recyclable. Whereas the traditional microcontact printing technique facilitates only negative lithography, the synergetic interaction of the silk, water, and common chemicals in our technique enables both positive and negative patterning using a single stamp...
April 9, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29682605/dual-affinity-heparin-based-hydrogels-achieve-pro-regenerative-immunomodulation-and-microvascular-remodeling
#3
Molly E Ogle, Jack R Krieger, Liane E Tellier, Jennifer McFaline-Figueroa, Johnna S Temenoff, Edward A Botchwey
The immune response to biomaterial implants critically regulates functional outcomes such as vascularization, transplant integration/survival, and fibrosis. To create "immunologically smart" materials, the host-material response may be engineered to optimize the recruitment of pro-regenerative leukocyte subsets which mature into corresponding wound-healing macrophages. We have recently identified a unique feature of pro-regenerative Ly6Clow monocytes that is a higher expression of both the bioactive lipid receptor sphingosine-1-phosphate receptor 3 (S1PR3) and the stromal derived factor-1α (SDF-1α) receptor CXCR4...
April 9, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29682604/the-hair-follicle-an-underutilized-source-of-cells-and-materials-for-regenerative-medicine
#4
Mehrdad T Kiani, Claire A Higgins, Benjamin D Almquist
The hair follicle is one of only two structures within the adult body that selectively degenerates and regenerates, making it an intriguing organ to study and use for regenerative medicine. Hair follicles have been shown to influence wound healing, angiogenesis, neurogenesis, and harbor distinct populations of stem cells; this has led to cells from the follicle being used in clinical trials for tendinosis and chronic ulcers. In addition, keratin produced by the follicle in the form of a hair fiber provides an abundant source of biomaterials for regenerative medicine...
April 9, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29552635/isolation-and-identification-of-proteins-secreted-by-cells-cultured-within-synthetic-hydrogel-based-matrices
#5
Lisa A Sawicki, Leila H Choe, Katherine L Wiley, Kelvin H Lee, April M Kloxin
Cells interact with and remodel their microenvironment, degrading large extracellular matrix (ECM) proteins (e.g., fibronectin, collagens) and secreting new ECM proteins and small soluble factors (e.g., growth factors, cytokines). Synthetic mimics of the ECM have been developed as controlled cell culture platforms for use in both fundamental and applied studies. However, how cells broadly remodel these initially well-defined matrices remains poorly understood and difficult to probe. In this work, we have established methods for widely examining both large and small proteins that are secreted by cells within synthetic matrices...
March 12, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29862316/role-of-cell-mediated-enzymatic-degradation-and-cytoskeletal-tension-on-dynamic-changes-in-the-rheology-of-the-pericellular-region-prior-to-human-mesenchymal-stem-cell-motility
#6
Maryam Daviran, Hugo S Caram, Kelly M Schultz
Human mesenchymal stem cells (hMSCs) are encapsulated in synthetic matrix metalloproteinase (MMP) degradable poly(ethylene glycol)-peptide hydrogels to characterize cell-mediated degradation of the pericellular region using multiple particle tracking microrheology. The hydrogel scaffold is degraded by cell-secreted enzymes and cytoskeletal tension. We determine that cell-secreted enzymatic degradation is the main contributor to changes in the pericellular region, with cytoskeletal tension playing a minimal role...
February 12, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29805991/genetically-encoded-toolbox-for-glycocalyx-engineering-tunable-control-of-cell-adhesion-survival-and-cancer-cell-behaviors
#7
Carolyn R Shurer, Marshall J Colville, Vivek K Gupta, Shelby E Head, FuiBoon Kai, Jonathon N Lakins, Matthew J Paszek
The glycocalyx is a coating of protein and sugar on the surface of all living cells. Dramatic perturbations to the composition and structure of the glycocalyx are frequently observed in aggressive cancers. However, tools to experimentally mimic and model the cancer-specific glycocalyx remain limited. Here, we develop a genetically encoded toolkit to engineer the chemical and physical structure of the cellular glycocalyx. By manipulating the glycocalyx structure, we are able to switch the adhesive state of cells from strongly adherent to fully detached...
February 12, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29756030/3d-tissue-engineered-in-vitro-models-of-cancer-in-bone
#8
Anna M Sitarski, Heather Fairfield, Carolyne Falank, Michaela R Reagan
Biological models are necessary tools for gaining insight into underlying mechanisms governing complex pathologies such as cancer in the bone. Models range from in vitro tissue culture systems to in vivo models and can be used with corresponding epidemiological and clinical data to understand disease etiology, progression, driver mutations, and signaling pathways. In bone cancer, as with many other cancers, in vivo models are often too complex to study specific cell-cell interactions or protein roles, and 2D models are often too simple to accurately represent disease processes...
February 12, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29623292/mirna-extraction-from-cell-free-biofluid-using-protein-corona-formed-around-carboxyl-magnetic-nanoparticles
#9
Shengqiang Xu, Seyedmehdi Hossaini Nasr, Daoyang Chen, Xiaoxian Zhang, Liangliang Sun, Xuefei Huang, Chunqi Qian
MicroRNA (miRNA) in urine has been considered as a potential biomarker for early-stage diagnosis of multiple diseases like urinary system cancer, kidney injury and diabetes, owing to their many demonstrated advantages including long-term stability and noninvasiveness. However, the traditional enrichment and extraction processes of miRNAs from urine are cumbersome and tedious due to the low concentration and multiple carriers of miRNAs. Herein, we present a novel method to collect low concentrations of miRNAs from dilute solutions such as urine and cell culture medium...
February 12, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29527571/comparative-study-of-multicellular-tumor-spheroid-formation-methods-and-implications-for-drug-screening
#10
Maria F Gencoglu, Lauren E Barney, Christopher L Hall, Elizabeth A Brooks, Alyssa D Schwartz, Daniel C Corbett, Kelly R Stevens, Shelly R Peyton
Improved in vitro models are needed to better understand cancer progression and bridge the gap between in vitro proof-of-concept studies, in vivo validation, and clinical application. Multicellular tumor spheroids (MCTS) are a popular method for three-dimensional (3D) cell culture, because they capture some aspects of the dimensionality, cell-cell contact, and cell-matrix interactions seen in vivo. Many approaches exist to create MCTS from cell lines, and they have been used to study tumor cell invasion, growth, and how cells respond to drugs in physiologically relevant 3D microenvironments...
February 12, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29457129/in-vitro-modeling-of-mechanics-in-cancer-metastasis
#11
REVIEW
Andrea Malandrino, Roger D Kamm, Emad Moeendarbary
In addition to a multitude of genetic and biochemical alterations, abnormal morphological, structural, and mechanical changes in cells and their extracellular environment are key features of tumor invasion and metastasis. Furthermore, it is now evident that mechanical cues alongside biochemical signals contribute to critical steps of cancer initiation, progression, and spread. Despite its importance, it is very challenging to study mechanics of different steps of metastasis in the clinic or even in animal models...
February 12, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29713681/porous-substrates-promote-endothelial-migration-at-the-expense-of-fibronectin-fibrillogenesis
#12
Henry H Chung, Stephanie M Casillo, Spencer J Perry, Thomas R Gaborski
Porous substrates have gained increased usage in cell studies and tissue mimetic applications because they can partition distinct cell types while still allowing important biochemical crosstalk. In the presented work, we investigated how porous substrates with micron and submicron features influence early cell migration and the associated ECM establishment, which can critically affect the rate of cell coverage on the substrate and the ensuing tissue organization. We showed through time-lapse microscopy that cell speed and migratory distance on membranes with 0...
January 8, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29457128/evaluation-of-hydrogels-presenting-extracellular-matrix-derived-adhesion-peptides-and-encapsulating-cardiac-progenitor-cells-for-cardiac-repair
#13
Srishti Bhutani, Aline L Y Nachlas, Milton E Brown, Tionne Pete, Christopher T Johnson, Andres J García, Michael E Davis
Cell therapy is an emerging paradigm for the treatment of heart disease. In spite of the exciting and promising preclinical results, the benefits of cell therapy for cardiac repair in patients have been modest at best. Biomaterials-based approaches may overcome the barriers of poor differentiation and retention of transplanted cells. In this study, we prepared and tested hydrogels presenting extracellular matrix (ECM)-derived adhesion peptides as delivery vehicles for c-kit+ cardiac progenitor cells (CPCs)...
January 8, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29333491/multifunctional-bioreactor-system-for-human-intestine-tissues
#14
Wenda Zhou, Ying Chen, Terrence Roh, Yinan Lin, Shengjie Ling, Siwei Zhao, James D Lin, Noor Khalil, Dana M Cairns, Eleana Manousiouthakis, Megan Tse, David L Kaplan
The three-dimensional (3D) cultivation of intestinal cells and tissues in dynamic bioreactor systems to represent in vivo intestinal microenvironments is essential for developing regenerative medicine treatments for intestinal diseases. We have previously developed in vitro human intestinal tissue systems using a 3D porous silk scaffold system with intestinal architectures and topographical features for the adhesion, growth, and differentiation of intestinal cells under static culture conditions. In this study, we designed and fabricated a multifunctional bioreactor system that incorporates pre-epithelialized 3D silk scaffolds in a dynamic culture environment for in vitro engineering of human intestine tissues...
January 8, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29333490/inhibition-of-bacterial-adhesion-on-nanotextured-stainless-steel-316l-by-electrochemical-etching
#15
Yeongseon Jang, Won Tae Choi, Christopher T Johnson, Andrés J García, Preet M Singh, Victor Breedveld, Dennis W Hess, Julie A Champion
Bacterial adhesion to stainless steel 316L (SS316L), which is an alloy typically used in many medical devices and food processing equipment, can cause serious infections along with substantial healthcare costs. This work demonstrates that nanotextured SS316L surfaces produced by electrochemical etching effectively inhibit bacterial adhesion of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus , but exhibit cytocompatibility and no toxicity toward mammalian cells in vitro. Additionally, the electrochemical surface modification on SS316L results in formation of superior passive layer at the surface, improving corrosion resistance...
January 8, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29687080/multidomain-peptide-hydrogel-accelerates-healing-of-full-thickness-wounds-in-diabetic-mice
#16
Nicole C Carrejo, Amanda N Moore, Tania L Lopez Silva, David G Leach, I-Che Li, Douglas R Walker, Jeffrey D Hartgerink
In vivo, multidomain peptide (MDP) hydrogels undergo rapid cell infiltration and elicit a mild inflammatory response which promotes angiogenesis. Over time, the nanofibers are degraded and a natural collagen-based extracellular matrix is produced remodeling the artificial material into natural tissue. These properties make MDPs particularly well suited for applications in regeneration. In this work, we test the regenerative potential of MDP hydrogels in a diabetic wound healing model. When applied to full-thickness dermal wounds in genetically diabetic mice, the MDP hydrogel resulted in significantly accelerated wound healing compared to a clinically used hydrogel, as well as a control buffer...
2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29527570/synthesis-of-microgel-sensors-for-spatial-and-temporal-monitoring-of-protease-activity
#17
Della S Shin, Emi Y Tokuda, Jennifer L Leight, Connor E Miksch, Tobin E Brown, Kristi S Anseth
Proteases are involved in almost every important cellular activity, from embryonic morphogenesis to apoptosis. To study protease activity in situ , hydrogels provide a synthetic mimic of the extracellular matrix (ECM) and have utility as a platform to study activity, such as those related to cell migration, in three-dimensions. While 3-dimensional visualization of protease activity could prove quite useful to elucidate the proteolytic interaction at the interface between cells and their surrounding environment, there has been no versatile tool to visualize local proteolytic activity in real time...
2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29707631/polymer-microneedle-mediated-local-aptamer-delivery-for-blocking-the-function-of-vascular-endothelial-growth-factor
#18
James Coyne, Brandon Davis, David Kauffman, Nan Zhao, Yong Wang
Overexpression of proteins in the body can cause severe diseases and other physiological disturbances. The development of protein blockers and local delivery systems would offer opportunities for addressing the health problems caused by protein overexpression. Nucleic acid aptamers are an emerging class of ligands with the potential to block proteins effectively; however, little effort has been made in developing polymer systems for local aptamer delivery. In this work, polymer microneedles capable of delivering DNA aptamers locally to inhibit the function of vascular endothelial growth factor (VEGF) were developed and studied...
December 11, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29479561/using-biomimetic-polymers-in-place-of-noncollagenous-proteins-to-achieve-functional-remineralization-of-dentin-tissues
#19
Yung-Ching Chien, Jinhui Tao, Kuniko Saeki, Alexander F Chin, Jolene L Lau, Chun-Long Chen, Ronald N Zuckermann, Sally J Marshall, Grayson W Marshall, James J De Yoreo
In calcified tissues such as bones and teeth, mineralization is regulated by an extracellular matrix, which includes non-collagenous proteins (NCP). This natural process has been adapted or mimicked to restore tissues following physical damage or demineralization by using polyanionic acids in place of NCPs, but the remineralized tissues fail to fully recover their mechanical properties. Here we show that pre-treatment with certain amphiphilic peptoids, a class of peptide-like polymers consisting of N-substituted glycines that have defined monomer sequences, enhances ordering and mineralization of collagen and induces functional remineralization of dentin lesions in vitro ...
December 11, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29302619/protein-mimetic-and-anticancer-properties-of-monocyte-targeting-peptide-amphiphile-micelles
#20
Christopher Poon, Sampreeti Chowdhuri, Cheng-Hsiang Kuo, Yun Fang, Francis J Alenghat, Danielle Hyatt, Kian Kani, Mitchell E Gross, Eun Ji Chung
Monocyte chemoattractant protein-1 (MCP-1) stimulates the migration of monocytes to inflammatory sites, leading to the progression of many diseases. Recently, we described a monocyte-targeting peptide amphiphile micelle (MCP-1 PAM) incorporated with the chemokine receptor CCR2 binding motif of MCP-1, which has a high affinity for monocytes in atherosclerotic plaques. We further report here the biomimetic components of MCP-1 PAMs and the influence of the nanoparticle upon binding to monocytes. We report that MCP-1 PAMs have enhanced secondary structure compared to the MCP-1 peptide...
December 11, 2017: ACS Biomaterials Science & Engineering
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