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Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

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https://www.readbyqxmd.com/read/29322089/the-wisconsin-registry-for-alzheimer-s-prevention-a-review-of-findings-and-current-directions
#1
REVIEW
Sterling C Johnson, Rebecca L Koscik, Erin M Jonaitis, Lindsay R Clark, Kimberly D Mueller, Sara E Berman, Barbara B Bendlin, Corinne D Engelman, Ozioma C Okonkwo, Kirk J Hogan, Sanjay Asthana, Cynthia M Carlsson, Bruce P Hermann, Mark A Sager
The Wisconsin Registry for Alzheimer's Prevention is a longitudinal observational cohort study enriched with persons with a parental history (PH) of probable Alzheimer's disease (AD) dementia. Since late 2001, Wisconsin Registry for Alzheimer's Prevention has enrolled 1561 people at a mean baseline age of 54 years. Participants return for a second visit 4 years after baseline, and subsequent visits occur every 2 years. Eighty-one percent (1270) of participants remain active in the study at a current mean age of 64 and 9 years of follow-up...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29255789/type-2-diabetes-mellitus-and-cerebrospinal-fluid-alzheimer-s-disease-biomarker-amyloid-%C3%AE-1-42-in-alzheimer-s-disease-neuroimaging-initiative-participants
#2
Wei Li, Shannon L Risacher, Sujuan Gao, Stephen L Boehm, Jeffrey S Elmendorf, Andrew J Saykin
Introduction: Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease. Cerebrospinal fluid (CSF) amyloid β (Aβ) 1-42 is an important Alzheimer's disease biomarker. However, it is inconclusive on how T2DM is related to CSF Aβ1-42. Methods: Participants with T2DM were selected from the Alzheimer's Disease Neuroimaging Initiative by searching keywords from the medical history database. A two-way analysis of covariance model was used to analyze how T2DM associates with CSF Aβ1-42 or cerebral cortical Aβ...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29255788/changes-in-place-of-death-among-people-with-dementia-in-finland-between-1998-and-2013-a-register-study
#3
Yaeko Masuchi, Marja Jylhä, Jani Raitanen, Mari Aaltonen
Introduction: The place of death is suggested as a quality indicator for end-of-life care. We investigated how the place of death changed between 1998 and 2013 among people with dementia. Methods: Data from the Finnish national health and social care registers were extracted for all people with dementia, who had died at 70 years old during these years (N = 140,034). Descriptive analysis and logistic regression analysis were conducted. Results: In 2013, the most common place of death was the primary care hospital (39...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29255787/continuous-measurement-of-object-location-memory-is-sensitive-to-effects-of-age-and-mild-cognitive-impairment-and-related-to-medial-temporal-lobe-volume
#4
Benjamin M Hampstead, Stephen Towler, Anthony Y Stringer, Krishnankutty Sathian
Introduction: We present findings of a novel and ecologically relevant associative memory test, the Object Location Touchscreen Test (OLTT), which was posited as sensitive to early medial temporal lobe compromise associated with mild cognitive impairment (MCI). Methods: A total of 114 participants, including healthy young and older controls and patients with MCI, completed the OLTT and standard neuropsychological testing. The OLTT required participants to recall the location of objects under free and cued recall conditions, with accuracy evaluated using distance measures (i...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29234723/free-and-cued-selective-reminding-test-sensitivity
#5
Raphael M Castilhos, Marcia L Chaves
No abstract text is available yet for this article.
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29201991/white-matter-signal-abnormalities-in-former-national-football-league-players
#6
Michael L Alosco, Inga K Koerte, Yorghos Tripodis, Megan Mariani, Alicia S Chua, Johnny Jarnagin, Yashar Rahimpour, Christian Puzo, Rose C Healy, Brett Martin, Christine E Chaisson, Robert C Cantu, Rhoda Au, Michael McClean, Ann C McKee, Alexander P Lin, Martha E Shenton, Ronald J Killiany, Robert A Stern
Introduction: Later-life brain alterations in former tackle football players are poorly understood, particularly regarding their relationship with repetitive head impacts (RHIs) and clinical function. We examined white matter signal abnormalities (WMSAs) and their association with RHIs and clinical function in former National Football League (NFL) players. Methods: Eighty-six clinically symptomatic former NFL players and 23 same-age reportedly asymptomatic controls without head trauma exposure underwent magnetic resonance imaging and neuropsychological testing...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29201990/retinal-thickness-correlates-with-parietal-cortical-atrophy-in-early-onset-alzheimer-s-disease-and-controls
#7
Jurre den Haan, Sarah F Janssen, Jacoba A van de Kreeke, Philip Scheltens, Frank D Verbraak, Femke H Bouwman
Introduction: The retina may reflect Alzheimer's disease (AD) neuropathological changes and is easily visualized with optical coherence tomography (OCT). Retinal thickness decrease has been correlated to AD, however, without information on amyloid status. We correlated retinal (layer) thickness to AD biomarkers in amyloid-positive early-onset AD (EOAD) patients and amyloid-negative controls. Methods: We measured macular thickness and peripapillary retinal nerve fiber layer thickness with OCT in 15 EOAD patients and 15 controls and correlated retinal thickness to visual rating scores for atrophy on magnetic resonance imaging...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29159267/long-term-impact-of-intensive-lifestyle-intervention-on-cognitive-function-assessed-with-the-national-institutes-of-health-toolbox-the-look-ahead-study
#8
Kathleen M Hayden, Laura D Baker, George Bray, Raymond Carvajal, Kathryn Demos-McDermott, Andrea L Hergenroeder, James O Hill, Edward Horton, John M Jakicic, Karen C Johnson, Rebecca H Neiberg, Stephen R Rapp, Thomas A Wadden, Michael E Miller
Introduction: This study sought to determine whether 10 years of assignment to intensive lifestyle intervention (ILI) relative to diabetes support and education leads to better cognition. We examine intervention effects overall and among clinical subgroups, and report correlations between computer-administered and interviewer-administered cognitive batteries. Methods: The Action for Health in Diabetes (Look AHEAD) was a 16-site randomized controlled trial with overweight/obese individuals (aged 45-76) who had type 2 diabetes...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29159266/analysis-of-macrolinguistic-aspects-of-narratives-from-individuals-with-alzheimer-s-disease-mild-cognitive-impairment-and-no-cognitive-impairment
#9
Cíntia Matsuda Toledo, Sandra Maria Aluísio, Leandro Borges Dos Santos, Sonia Maria Dozzi Brucki, Eduardo Sturzeneker Trés, Maira Okada de Oliveira, Letícia Lessa Mansur
Introduction: The depiction of features in discourse production promotes accurate diagnosis and helps to establish the therapeutic intervention in cognitive impairment and dementia. We aimed to identify alterations in the macrolinguistic aspects of discourse using a new computational tool. Methods: Sixty individuals, aged 60 years and older, were distributed in three different groups: mild Alzheimer's disease (mAD), amnestic mild cognitive impairment, and healthy controls...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29159265/characterizing-biomarker-features-of-cognitively-normal-individuals-with-ventriculomegaly
#10
Xiaofeng Li, Maowen Ba, Kok Pin Ng, Sulantha Mathotaarachchi, Tharick A Pascoal, Pedro Rosa-Neto, Serge Gauthier
Introduction: The clinical significance of ventriculomegaly in cognitively normal elderly individuals remains unclear. Methods: We selected cognitively normal individuals (n = 425) from the Alzheimer's Disease Neuroimaging Initiative database and calculated Evans index (EI) based on the ratio of the frontal horn and skull diameter. We defined ventriculomegaly as EI ≥ 0.30, and the participants were stratified into EI ≥ 0.30 group and EI < 0.30 group...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29159264/the-effects-of-apolipoprotein-e-genotype-%C3%AE-synuclein-deficiency-and-sex-on-brain-synaptic-and-alzheimer-s-disease-related-pathology
#11
Roni Bar, Anat Boehm-Cagan, Ishai Luz, Yarden Kleper-Wall, Daniel M Michaelson
Introduction: Alzheimer's disease (AD) and synucleinopathies share common pathological mechanisms. Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for AD, also increases the risk for dementia in pure synucleinopathies. We presently examined the effects of α-synuclein deficiency (α-syn-/-) and sex on apoE4-driven pathologies. Methods: AD-related, synaptic, and vascular markers were analyzed in female and male α-syn-/- and α-syn+/+ apoE4, apoE3, and apoE3/E4 mice...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29034310/further-education-improves-cognitive-reserve-and-triggers-improvement-in-selective-cognitive-functions-in-older-adults-the-tasmanian-healthy-brain-project
#12
Megan E Thow, Mathew J Summers, Nichole L Saunders, Jeffery J Summers, Karen Ritchie, James C Vickers
INTRODUCTION: The strong link between early-life education and subsequent reduced risk of dementia suggests that education in later life could enhance cognitive function and may reduce age-related cognitive decline and protect against dementia. METHODS: Episodic memory, working memory, executive function, and language processing performances were assessed annually over 4 years in 359 healthy older adults who attended university for a minimum of 12 months (intervention) and were compared against 100 healthy adult controls...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29255790/letter
#13
Ara S Khachaturian
No abstract text is available yet for this article.
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29234724/lower-cerebral-blood-flow-in-subjects-with-alzheimer-s-dementia-mild-cognitive-impairment-and-subjective-cognitive-decline-using-two-dimensional-phase-contrast-magnetic-resonance-imaging
#14
Jolien F Leijenaar, Ingrid S van Maurik, Joost P A Kuijer, Wiesje M van der Flier, Philip Scheltens, Frederik Barkhof, Niels D Prins
Introduction: In this cross-sectional study, we aimed to detect differences in cerebral blood flow (CBF) between subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and subjective cognitive decline (SCD), using two-dimensional phase-contrast magnetic resonance imaging. Methods: We included 74 AD patients (67 years, 51% female), 36 MCI patients (66 years, 33% female), and 62 patients with SCD (60 years, 32% female) from the Amsterdam Dementia Cohort...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29201992/probability-of-alzheimer-s-disease-in-breast-cancer-survivors-based-on-gray-matter-structural-network-efficiency
#15
Shelli R Kesler, Vikram Rao, William J Ray, Arvind Rao
Introduction: Breast cancer chemotherapy is associated with accelerated aging and potentially increased risk for Alzheimer's disease (AD). Methods: We calculated the probability of AD diagnosis from brain network and demographic and genetic data obtained from 47 female AD converters and 47 matched healthy controls. We then applied this algorithm to data from 78 breast cancer survivors. Results: The classifier discriminated between AD and healthy controls with 86% accuracy (P < ...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29159268/olfactory-identification-in-subjective-cognitive-decline-and-mild-cognitive-impairment-association-with-tau-but-not-amyloid-positron-emission-tomography
#16
Shannon L Risacher, Eileen F Tallman, John D West, Karmen K Yoder, Gary D Hutchins, James W Fletcher, Sujuan Gao, David A Kareken, Martin R Farlow, Liana G Apostolova, Andrew J Saykin
Introduction: We investigated the association between olfactory identification and Alzheimer's disease biomarkers, including amyloid, tau, and neurodegeneration. Methods: Thirty-four older adults, including 19 cognitively normal (CN), 10 subjective cognitive decline (SCD), and 5 mild cognitive impairment, underwent amyloid positron emission tomography, magnetic resonance imaging, and the University of Pennsylvania Smell Identification Test (UPSIT). Twenty-six also underwent tau positron emission tomography...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28983503/alzheimer-s-disease-genetic-risk-variants-beyond-apoe-%C3%AE%C2%B54-predict-mortality
#17
Jesse Mez, Jessica R Marden, Shubhabrata Mukherjee, Stefan Walter, Laura E Gibbons, Alden L Gross, Laura B Zahodne, Paola Gilsanz, Paul Brewster, Kwangsik Nho, Paul K Crane, Eric B Larson, M Maria Glymour
INTRODUCTION: We hypothesized that, like apolipoprotein E (APOE), other late-onset Alzheimer's disease (LOAD) genetic susceptibility loci predict mortality. METHODS: We used a weighted genetic risk score (GRS) from 21 non-APOE LOAD risk variants to predict survival in the Adult Changes in Thought and the Health and Retirement Studies. We meta-analyzed hazard ratios and examined models adjusted for cognitive performance or limited to participants with dementia. For replication, we assessed the GRS-longevity association in the Cohorts for Heart and Aging Research in Genomic Epidemiology, comparing cases surviving to age ≥90 years with controls who died between ages 55 and 80 years...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28975146/effect-of-apolipoprotein-e-phenotype-on-the-association-of-plasma-amyloid%C3%A2-%C3%AE-and-amyloid-positron-emission-tomography-imaging-in-japan
#18
Amane Tateno, Takeshi Sakayori, Woo Chan Kim, Michihiko Koeda, Shinichiro Kumita, Hidenori Suzuki, Yoshiro Okubo
INTRODUCTION: The plasma concentration of beta-amyloid (Aβ) has been considered another biomarker of Alzheimer's disease and was reportedly associated with cortical Aβ accumulation. METHODS: We analyzed 28 subjects with apolipoprotein E4 (ApoE4; E4 group) and 89 subjects without ApoE4 (non-E4 group) to determine the association between cortical Aβ accumulation by standard uptake value ratio with [(18)F]florbetapir positron emission tomography and plasma Aβ1-40 and Aβ1-42...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28971142/entorhinal-and-transentorhinal-atrophy-in-mild-cognitive-impairment-using-longitudinal-diffeomorphometry
#19
Daniel J Tward, Chelsea S Sicat, Timothy Brown, Arnold Bakker, Michela Gallagher, Marilyn Albert, Michael Miller
INTRODUCTION: Autopsy findings have shown the entorhinal cortex and transentorhinal cortex are among the earliest sites of accumulation of pathology in patients developing Alzheimer's disease. METHODS: Here, we study this region in subjects with mild cognitive impairment (n = 36) and in control subjects (n = 16). The cortical areas are manually segmented, and local volume and shape changes are quantified using diffeomorphometry, including a novel mapping procedure that reduces variability in anatomic definitions over time...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28951883/blood-based-metabolic-signatures-in-alzheimer-s-disease
#20
Francisca A de Leeuw, Carel F W Peeters, Maartje I Kester, Amy C Harms, Eduard A Struys, Thomas Hankemeier, Herman W T van Vlijmen, Sven J van der Lee, Cornelia M van Duijn, Philip Scheltens, Ayşe Demirkan, Mark A van de Wiel, Wiesje M van der Flier, Charlotte E Teunissen
INTRODUCTION: Identification of blood-based metabolic changes might provide early and easy-to-obtain biomarkers. METHODS: We included 127 Alzheimer's disease (AD) patients and 121 control subjects with cerebrospinal fluid biomarker-confirmed diagnosis (cutoff tau/amyloid β peptide 42: 0.52). Mass spectrometry platforms determined the concentrations of 53 amine compounds, 22 organic acid compounds, 120 lipid compounds, and 40 oxidative stress compounds. Multiple signatures were assessed: differential expression (nested linear models), classification (logistic regression), and regulatory (network extraction)...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
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