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Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

journal
https://www.readbyqxmd.com/read/28054030/prospective-associations-of-plasma-phospholipids-and-mild-cognitive-impairment-dementia-among-african-americans-in-the-aric-neurocognitive-study
#1
Danni Li, Jeffrey R Misialek, Eric Boerwinkle, Rebecca F Gottesman, A Richey Sharrett, Thomas H Mosley, Josef Coresh, Lisa M Wruck, David S Knopman, Alvaro Alonso
INTRODUCTION: The objective of this study was to investigate whether 10 phospholipids/metabolites previously identified as prospectively predictive of mild cognitive impairment (MCI) or dementia in whites would also be predictive in a mostly African-American cohort. METHODS: We repeatedly measured 188 phospholipids/metabolites in plasma samples of 221 participants of the Atherosclerosis Risk in Communities study, 97% African American, who were followed between 2004-2006 and 2011-2013...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054029/introduction-to-special-edition-state-of-the-field-advances-in-neuroimaging-from-the-2016-alzheimer-s-imaging-consortium
#2
EDITORIAL
Elizabeth C Mormino, David A Wolk, Liana G Apostolova
No abstract text is available yet for this article.
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054028/the-effect-of-the-top-20-alzheimer-disease-risk-genes-on-gray-matter-density-and-fdg-pet-brain-metabolism
#3
Eddie Stage, Tugce Duran, Shannon L Risacher, Naira Goukasian, Triet M Do, John D West, Holly Wilhalme, Kwangsik Nho, Meredith Phillips, David Elashoff, Andrew J Saykin, Liana G Apostolova
INTRODUCTION: We analyzed the effects of the top 20 Alzheimer disease (AD) risk genes on gray-matter density (GMD) and metabolism. METHODS: We ran stepwise linear regression analysis using posterior cingulate hypometabolism and medial temporal GMD as outcomes and all risk variants as predictors while controlling for age, gender, and APOE ε4 genotype. We explored the results in 3D using Statistical Parametric Mapping 8. RESULTS: Significant predictors of brain GMD were SLC24A4/RIN3 in the pooled and mild cognitive impairment (MCI); ZCWPW1 in the MCI; and ABCA7, EPHA1, and INPP5D in the AD groups...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054027/thinner-temporal-and-parietal-cortex-is-related-to-incident-clinical-progression-to-dementia-in-patients-with-subjective-cognitive-decline
#4
REVIEW
Sander C J Verfaillie, Betty Tijms, Adriaan Versteeg, Marije R Benedictus, Femke H Bouwman, Philip Scheltens, Frederik Barkhof, Hugo Vrenken, Wiesje M van der Flier
INTRODUCTION: We aimed to investigate if thinner cortex of the Alzheimer's disease (AD)-signature region was related to clinical progression in patients with subjective cognitive decline (SCD). METHODS: We included 302 SCD patients with clinical follow-up (≥1 year) and three-dimensional T1 magnetic resonance imaging. We estimated AD-signature cortical thickness, consisting of nine frontal, parietal, and temporal gyri and hippocampal volume. We used Cox proportional hazard models (hazard ratios and 95% confidence intervals) to evaluate cortical thickness in relation to clinical progression to mild cognitive impairment (MCI) or dementia...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054026/degradation-in-intrinsic-connectivity-networks-across-the-alzheimer-s-disease-spectrum
#5
Rachel Nuttall, Lorenzo Pasquini, Martin Scherr, Christian Sorg
INTRODUCTION: Changes in intrinsic functional connectivity (iFC) have been reported at various stages of the Alzheimer's disease (AD) spectrum. We aimed to investigate such alterations over a variety of large-scale intrinsic brain networks (iBNs) across the spectrum of amyloid β positivity and uncover their relation to cognitive impairment. METHODS: Eight iBNs were defined from resting-state functional magnetic resonance imaging data. In amyloid β-positive healthy subjects, prodromal, and AD patients (N = 70), within-network iFC (intra-iFC) and between-network iFC (inter-iFC) were correlated with scores of cognitive impairment...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054025/qualitative-and-quantitative-assessment-of-self-reported-cognitive-difficulties-in-nondemented-elders-association-with-medical-help-seeking-cognitive-deficits-and-%C3%AE-amyloid-imaging
#6
Renaud La Joie, Audrey Perrotin, Stéphanie Egret, Florence Pasquier, Clémence Tomadesso, Florence Mézenge, Béatrice Desgranges, Vincent de La Sayette, Gaël Chételat
INTRODUCTION: Subjective cognitive decline (SCD) could help identify early stages of Alzheimer's disease. However, SCD is multidetermined and protean, and the type of cognitive complaint associated with preclinical Alzheimer's disease needs refinement. METHODS: A total of 185 nondemented elders recruited from either the community or from a memory clinic filled a questionnaire. We searched for item responses associated with medical help seeking, cognitive deficits, and β-amyloidosis...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054024/critical-review-of-the-appropriate-use-criteria-for-amyloid-imaging-effect-on-diagnosis-and-patient-care
#7
Liana G Apostolova, Janelle M Haider, Naira Goukasian, Gil D Rabinovici, Gael Chételat, John M Ringman, Sarah Kremen, Joshua D Grill, Lucas Restrepo, Mario F Mendez, Daniel H Silverman
INTRODUCTION: The utility of the Appropriate Use Criteria (AUC) for amyloid imaging is not established. METHODS: Fifty-three cognitively impaired patients with clinical F(18)-florbetapir imaging were classified as early and late onset, as well as AUC-consistent or AUC-inconsistent. Chi-square statistics and t test were used to compare demographic characteristics and clinical outcomes as appropriate. RESULTS: Early-onset patients were more likely to be amyloid positive...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054023/imaging-markers-of-cerebrovascular-pathologies-pathophysiology-clinical-presentation-and-risk-factors
#8
REVIEW
Mekala R Raman, Kejal Kantarci, Melissa E Murray, Clifford R Jack, Prashanthi Vemuri
Cerebrovascular pathologies (CVPs) are common pathologies associated with age-related cognitive decline along with Alzheimer disease pathologies. The impact of CVP on the prevalence of dementia is increasingly being recognized. The goal of this review is to improve our understanding of the pathophysiological underpinnings and the multimodal magnetic resonance imaging and positron emission tomography imaging changes that are associated with the hallmarks of CVP. This knowledge will facilitate the development of early detection, intervention, and prevention strategies that may contribute to lowering the risk of dementia...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27872895/the-alzheimer-s-imaging-consortium-celebrating-20%C3%A2-years-of-creativity-and-progress
#9
EDITORIAL
Mony J de Leon
No abstract text is available yet for this article.
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27872894/perspective-from-the-alzheimer-s-association-neuroimaging-professional-interest-area-of-istaart-continues-impact-on-the-field
#10
EDITORIAL
Heather M Snyder, Maria C Carrillo
No abstract text is available yet for this article.
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27830174/nonvascular-retinal-imaging-markers-of-preclinical-alzheimer-s-disease
#11
Peter J Snyder, Lenworth N Johnson, Yen Ying Lim, Cláudia Y Santos, Jessica Alber, Paul Maruff, Brian Fernández
INTRODUCTION: In patients with Alzheimer's disease (AD) and mild cognitive impairment, structural changes in the retina (i.e., reduced thicknesses of the ganglion cell and retinal nerve fiber layers and inclusion bodies that appear to contain beta-amyloid protein [Ab]) have been previously reported. We sought to explore whether anatomic retinal changes are detectable in the preclinical stage of AD. METHODS: A cross-sectional study (as part of an ongoing longitudinal cohort study) involving 63 cognitively normal adults, all of whom have a parent with AD and subjective memory complaints...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27830173/alzheimer-s-disease-severity-objectively-determined-and-measured
#12
Alden L Gross, Dan M Mungas, Jeannie-Marie S Leoutsakos, Marilyn S Albert, Richard N Jones
INTRODUCTION: With expansion of clinical trials to individuals across the spectrum of Alzheimer disease (AD) from preclinical to symptomatic phases, it is increasingly important to quantify AD severity using methods that capture underlying pathophysiology. METHODS: We derived an AD severity measure based on biomarkers from brain imaging, neuropathology, and cognitive testing using latent variable modeling. We used data from ADNI-1 (N = 822) and applied findings to BIOCARD study (N = 349)...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27752537/modeling-practice-effects-in-healthy-middle-aged-participants-of-the-alzheimer-and-families-parent-cohort
#13
Gonzalo Sánchez-Benavides, Juan D Gispert, Karine Fauria, José Luis Molinuevo, Nina Gramunt
INTRODUCTION: Repetitive administration of neuropsychological tests can lead to performance improvement merely due to previous exposure. The magnitude of such practice effects (PEs) may be used as a marker of subtle cognitive impairment because they are diminished in healthy individuals subsequently developing Alzheimer's disease (AD). METHODS: To explore the relationship between sociodemographic factors, AD family history (FH), and APOE ε4 status, and the magnitude of PE, four subtests of the Wechsler Adult Intelligence Scale-IV were administered twice to 400 middle-aged healthy individuals, most of them first-degree descendants of AD patients...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27752536/a-critical-literature-review-of-the-effectiveness-of-various-instruments-in%C3%A2-the-diagnosis-of-dementia-in-adults-with-intellectual-disabilities
#14
Jordan Elliott-King, Sarah Shaw, Stephan Bandelow, Rajal Devshi, Shelina Kassam, Eef Hogervorst
INTRODUCTION: Currently, there is no consensus on dementia diagnostics in adults with intellectual disabilities (ID). There are three types of assessments available: direct cognitive tests, test batteries, and informant reports. METHODS: A systematic literature search was conducted in four databases yielding 9840 records. Relevant studies were identified and selected using predefined inclusion and exclusion criteria and then coded and classified according to assessment type...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27752535/middle-age-self-report-risk-score-predicts-cognitive-functioning-and-dementia-in-20-40%C3%A2-years
#15
Eero Vuoksimaa, Juha O Rinne, Noora Lindgren, Kauko Heikkilä, Markku Koskenvuo, Jaakko Kaprio
INTRODUCTION: On the basis of the proxy measures of cognitive reserve, we created a middle age self-report risk score for early prediction of dementia. METHODS: We used a longitudinal population-based study of 2602 individuals with a replication sample (N = 1011). Risk score at a mean age of 47 years was based on questions on educational and occupational attainments. Cognitive status at a mean age of 74 was determined via two validated telephone instruments. RESULTS: The prevalence of dementia was 10% after a mean follow-up of 28 years...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27752534/systemic-and-localized-extra-central-nervous-system-bacterial-infections-and-the-risk-of-dementia-among-us-veterans-a-retrospective-cohort-study
#16
Francis Mawanda, Robert B Wallace, Kimberly McCoy, Thad E Abrams
INTRODUCTION: Emerging evidence indicates associations between extra-central nervous system (CNS) bacterial infections and an increased risk for dementia; however, epidemiological evidence is still very limited. METHODS: This study involved a retrospective cohort of a national sample of US veterans (N = 417,172) aged ≥56 years. Extended Cox proportional hazard models adjusted for demographic characteristics and medical and psychiatric comorbidities determined the associations between systemic and localized extra-CNS bacterial infections occurring >2 years before the initial dementia diagnosis and the risk for dementia...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27722197/plasma-exosome-concentration-may-correlate-with-cognitive-impairment-in-parkinson-s-disease
#17
Yassar Alamri, Robert Vogel, Michael MacAskill, Tim Anderson
No abstract text is available yet for this article.
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27722196/random-forest-to-differentiate-dementia-with-lewy-bodies-from-alzheimer-s-disease
#18
Meenakshi Dauwan, Jessica J van der Zande, Edwin van Dellen, Iris E C Sommer, Philip Scheltens, Afina W Lemstra, Cornelis J Stam
INTRODUCTION: The aim of this study was to build a random forest classifier to improve the diagnostic accuracy in differentiating dementia with Lewy bodies (DLB) from Alzheimer's disease (AD) and to quantify the relevance of multimodal diagnostic measures, with a focus on electroencephalography (EEG). METHODS: A total of 66 DLB, 66 AD patients, and 66 controls were selected from the Amsterdam Dementia Cohort. Quantitative EEG (qEEG) measures were combined with clinical, neuropsychological, visual EEG, neuroimaging, and cerebrospinal fluid data...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27722195/carers-diaries-in-dementia-is-there-a-role-in-clinical-practice
#19
Dilini Jayalath, Kunle Ashaye, Lia Kvavilashvili
INTRODUCTION: Carers' diaries have been used in very few instances in dementia to assist with gathering information about persons with dementia in the community. The main aim of this study was to compare problems identified using diaries kept by family carers for a week with carers' oral recollection of problems. METHOD: Carers were randomly allocated into two groups, diary and control groups. In the diary group, carers received a diary and instructions on how to complete it for 7 days...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27722194/retinal-nerve-fiber-layer-thickness-in-amnestic-mild-cognitive-impairment-case-control-study-and-meta-analysis
#20
Brianna Knoll, Joseph Simonett, Nicholas J Volpe, Sina Farsiu, Mallory Ward, Alfred Rademaker, Sandra Weintraub, Amani A Fawzi
INTRODUCTION: Retinal structural changes in subjects with mild cognitive impairment (MCI) remain a subject of controversy. METHODS: We investigated the correlation between optical coherence tomography (OCT) of the retinal sublayers, including the retinal nerve fiber layer (RNFL), and cognitive function in subjects with amnestic MCI and compared the OCT findings with matched controls. We also performed a meta-analysis of the world literature using a random-effects model...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
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