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Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

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https://www.readbyqxmd.com/read/28217738/response-to-editor-to-the-comment-by-bastin-and-besson-2016-to-our-article-entitled-selective-familiarity-deficits-in-otherwise-cognitively-intact-aging-individuals-with-genetic-risk-for-alzheimer-s-disease
#1
Dorothee Schoemaker, Jens C Pruessner
No abstract text is available yet for this article.
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28217737/impaired-familiarity-in-individuals-at-risk-for-alzheimer-s-disease-commentary-on-schoemaker-et%C3%A2-al-2016
#2
Christine Bastin, Gabriel Besson
No abstract text is available yet for this article.
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28203628/the-structured-interview-for-insight-and-judgment-in-dementia-development-and-validation-of-a-new-instrument-to-assess-awareness-in-patients-with-dementia
#3
Teresa Parrao, Simone Brockman, Romola S Bucks, David G Bruce, Wendy A Davis, Katherine K Hatch, Tammy L Leavy, Christine A P Axten, Sergio E Starkstein
INTRODUCTION: Poor insight about their cognitive and functional deficits is highly prevalent in patients with Alzheimer's disease (AD); however, there is a lack of reliable, valid instrumentation to measure this construct. The aim of this study was to develop and validate a semistructured interview to assess insight and judgment in patients with AD and to provide information regarding the assessment of competency and risk in this population. METHODS: We validated the Structured Clinical Interview for Insight and Judgment in Dementia (SIJID) in a consecutive series of 124 patients with probable AD...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28149943/the-apoe-%C3%AE%C2%B54-genotype-modulates-csf-ykl-40-levels-and-their-structural-brain-correlates-in-the-continuum-of-alzheimer-s-disease-but-not-those-of-strem2
#4
Juan Domingo Gispert, Gemma C Monté, Marc Suárez-Calvet, Carles Falcon, Alan Tucholka, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo
INTRODUCTION: Among other metabolic functions, the apolipoprotein E (APOE) plays a crucial role in neuroinflammation. We aimed at assessing whether APOE ε4 modulates levels of glial cerebrospinal fluid (CSF) biomarkers and their structural cerebral correlates along the continuum of Alzheimer's disease (AD). METHODS: Brain magnetic resonance imaging (MRI) scans were acquired in 110 participants (49 control; 19 preclinical; 27 mild cognitive impairment [MCI] due to AD; 15 mild AD dementia) and CSF concentrations of YKL-40 and sTREM2 were determined...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28149942/cognitive-complaints-in-older-adults-at-risk-for-alzheimer-s-disease-are-associated-with-altered-resting-state-networks
#5
Joey A Contreras, Joaquín Goñi, Shannon L Risacher, Enrico Amico, Karmen Yoder, Mario Dzemidzic, John D West, Brenna C McDonald, Martin R Farlow, Olaf Sporns, Andrew J Saykin
INTRODUCTION: Pathophysiological changes that accompany early clinical symptoms in prodromal Alzheimer's disease (AD) may have a disruptive influence on brain networks. We investigated resting-state functional magnetic resonance imaging (rsfMRI), combined with brain connectomics, to assess changes in whole-brain functional connectivity (FC) in relation to neurocognitive variables. METHODS: Participants included 58 older adults who underwent rsfMRI. Individual FC matrices were computed based on a 278-region parcellation...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28149941/a-comparison-of-measurement-methods-of-hippocampal-atrophy-rate-for-predicting-alzheimer-s-dementia-in-the-aberdeen-birth-cohort-of-1936
#6
Arnab K Rana, Anca-Larisa Sandu, Kenna L Robertson, Christopher J McNeil, Lawrence J Whalley, Roger T Staff, Alison D Murray
INTRODUCTION: Various methods are available to measure hippocampal atrophy rate. We compared methods to predict Alzheimer's dementia. METHODS: Participants with brain imaging at ages 69 and 73 years were identified from a previous study. Simple manual measures and computationally automated volumetry were performed. Receiver operating characteristics assessed the predictive ability of each method at baseline and on logit regression analysis of two serial scans. RESULTS: Ten of 149 participants developed Alzheimer's dementia and had lower baseline volumes (3647 vs...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28138511/strokog-stroke-and-cognition-consortium-an-international-consortium-to-examine-the-epidemiology-diagnosis-and-treatment-of-neurocognitive-disorders-in-relation-to-cerebrovascular-disease
#7
Perminder S Sachdev, Jessica W Lo, John D Crawford, Lisa Mellon, Anne Hickey, David Williams, Régis Bordet, Anne-Marie Mendyk, Patrick Gelé, Dominique Deplanque, Hee-Joon Bae, Jae-Sung Lim, Amy Brodtmann, Emilio Werden, Toby Cumming, Sebastian Köhler, Frans R J Verhey, Yan-Hong Dong, Hui Hui Tan, Christopher Chen, Xu Xin, Raj N Kalaria, Louise M Allan, Rufus O Akinyemi, Adesola Ogunniyi, Aleksandra Klimkowicz-Mrowiec, Martin Dichgans, Frank A Wollenweber, Vera Zietemann, Michael Hoffmann, David W Desmond, Thomas Linden, Christian Blomstrand, Björn Fagerberg, Ingmar Skoog, Olivier Godefroy, Mélanie Barbay, Martine Roussel, Byung-Chul Lee, Kyung-Ho Yu, Joanna Wardlaw, Stephen J Makin, Fergus N Doubal, Francesca M Chappell, Velandai K Srikanth, Amanda G Thrift, Geoffrey A Donnan, Nagaendran Kandiah, Russell J Chander, Xuling Lin, Charlotte Cordonnier, Solene Moulin, Costanza Rossi, Behnam Sabayan, David J Stott, J Wouter Jukema, Susanna Melkas, Hanna Jokinen, Timo Erkinjuntti, Vincent C T Mok, Adrian Wong, Bonnie Y K Lam, Didier Leys, Hilde Hénon, Stéphanie Bombois, Darren M Lipnicki, Nicole A Kochan
INTRODUCTION: The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD). METHODS: Longitudinal studies with ≥75 participants who had suffered or were at risk of stroke or TIA and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28138510/tau-pet-uptake-regional-variation-in-average-suvr-and-impact-of-amyloid-deposition
#8
Prashanthi Vemuri, Val J Lowe, David S Knopman, Matthew L Senjem, Bradley J Kemp, Christopher G Schwarz, Scott A Przybelski, Mary M Machulda, Ronald C Petersen, Clifford R Jack
INTRODUCTION: Tau-positron emission tomography (PET) imaging with AV1451 is sensitive to Alzheimer disease (AD)-related tau deposition in the brain. We (1) examined regional variation of average tau-PET standardized uptake value ratios (SUVRs) in a young normal population (30-49 years) and corrected for the regional variability and (2) tested if the standardized values (z-scores) scaled appropriately to capture regional Alzheimer-specific (i.e., amyloid sensitive) tau-PET changes in individuals aged 50+ years...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28138509/association-between-a%C3%AE-and-tau-accumulations-and-their-influence-on-clinical-features-in-aging-and-alzheimer-s-disease-spectrum-brains-a-11-c-pbb3-pet-study
#9
Hitoshi Shimada, Soichiro Kitamura, Hitoshi Shinotoh, Hironobu Endo, Fumitoshi Niwa, Shigeki Hirano, Yasuyuki Kimura, Ming-Rong Zhang, Satoshi Kuwabara, Tetsuya Suhara, Makoto Higuchi
INTRODUCTION: Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear. METHODS: Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [(11)C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [(11)C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(-)-cognitive healthy controls (HCs)...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28116342/subsyndromal-delirium-compared-with-delirium-dementia-and-subjects-without-delirium-or-dementia-in-elderly-general-hospital-admissions-and-nursing-home-residents
#10
Esteban Sepulveda, Maeve Leonard, Jose G Franco, Dimitrios Adamis, Geraldine McCarthy, Colum Dunne, Paula T Trzepacz, Ana M Gaviria, Joan de Pablo, Elisabet Vilella, David J Meagher
INTRODUCTION: Subsyndromal delirium (SSD) complicates diagnosis of delirium and dementia, although there is little research comparing their symptom profiles. METHODS: Cross-sectional study of 400 elderly patients' admission to a general hospital or nursing home diagnosed with delirium, SSD, dementia, or no-delirium/no-dementia (NDND). Symptom profiles were assessed using the Delirium Rating Scale-Revised-98 (DRS-R98). RESULTS: Twenty percent patients had delirium, 19...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054030/prospective-associations-of-plasma-phospholipids-and-mild-cognitive-impairment-dementia-among-african-americans-in-the-aric-neurocognitive-study
#11
Danni Li, Jeffrey R Misialek, Eric Boerwinkle, Rebecca F Gottesman, A Richey Sharrett, Thomas H Mosley, Josef Coresh, Lisa M Wruck, David S Knopman, Alvaro Alonso
INTRODUCTION: The objective of this study was to investigate whether 10 phospholipids/metabolites previously identified as prospectively predictive of mild cognitive impairment (MCI) or dementia in whites would also be predictive in a mostly African-American cohort. METHODS: We repeatedly measured 188 phospholipids/metabolites in plasma samples of 221 participants of the Atherosclerosis Risk in Communities study, 97% African American, who were followed between 2004-2006 and 2011-2013...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054029/introduction-to-special-edition-state-of-the-field-advances-in-neuroimaging-from-the-2016-alzheimer-s-imaging-consortium
#12
EDITORIAL
Elizabeth C Mormino, David A Wolk, Liana G Apostolova
No abstract text is available yet for this article.
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054028/the-effect-of-the-top-20-alzheimer-disease-risk-genes-on-gray-matter-density-and-fdg-pet-brain-metabolism
#13
Eddie Stage, Tugce Duran, Shannon L Risacher, Naira Goukasian, Triet M Do, John D West, Holly Wilhalme, Kwangsik Nho, Meredith Phillips, David Elashoff, Andrew J Saykin, Liana G Apostolova
INTRODUCTION: We analyzed the effects of the top 20 Alzheimer disease (AD) risk genes on gray-matter density (GMD) and metabolism. METHODS: We ran stepwise linear regression analysis using posterior cingulate hypometabolism and medial temporal GMD as outcomes and all risk variants as predictors while controlling for age, gender, and APOE ε4 genotype. We explored the results in 3D using Statistical Parametric Mapping 8. RESULTS: Significant predictors of brain GMD were SLC24A4/RIN3 in the pooled and mild cognitive impairment (MCI); ZCWPW1 in the MCI; and ABCA7, EPHA1, and INPP5D in the AD groups...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054027/thinner-temporal-and-parietal-cortex-is-related-to-incident-clinical-progression-to-dementia-in-patients-with-subjective-cognitive-decline
#14
REVIEW
Sander C J Verfaillie, Betty Tijms, Adriaan Versteeg, Marije R Benedictus, Femke H Bouwman, Philip Scheltens, Frederik Barkhof, Hugo Vrenken, Wiesje M van der Flier
INTRODUCTION: We aimed to investigate if thinner cortex of the Alzheimer's disease (AD)-signature region was related to clinical progression in patients with subjective cognitive decline (SCD). METHODS: We included 302 SCD patients with clinical follow-up (≥1 year) and three-dimensional T1 magnetic resonance imaging. We estimated AD-signature cortical thickness, consisting of nine frontal, parietal, and temporal gyri and hippocampal volume. We used Cox proportional hazard models (hazard ratios and 95% confidence intervals) to evaluate cortical thickness in relation to clinical progression to mild cognitive impairment (MCI) or dementia...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054026/degradation-in-intrinsic-connectivity-networks-across-the-alzheimer-s-disease-spectrum
#15
Rachel Nuttall, Lorenzo Pasquini, Martin Scherr, Christian Sorg
INTRODUCTION: Changes in intrinsic functional connectivity (iFC) have been reported at various stages of the Alzheimer's disease (AD) spectrum. We aimed to investigate such alterations over a variety of large-scale intrinsic brain networks (iBNs) across the spectrum of amyloid β positivity and uncover their relation to cognitive impairment. METHODS: Eight iBNs were defined from resting-state functional magnetic resonance imaging data. In amyloid β-positive healthy subjects, prodromal, and AD patients (N = 70), within-network iFC (intra-iFC) and between-network iFC (inter-iFC) were correlated with scores of cognitive impairment...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054025/qualitative-and-quantitative-assessment-of-self-reported-cognitive-difficulties-in-nondemented-elders-association-with-medical-help-seeking-cognitive-deficits-and-%C3%AE-amyloid-imaging
#16
Renaud La Joie, Audrey Perrotin, Stéphanie Egret, Florence Pasquier, Clémence Tomadesso, Florence Mézenge, Béatrice Desgranges, Vincent de La Sayette, Gaël Chételat
INTRODUCTION: Subjective cognitive decline (SCD) could help identify early stages of Alzheimer's disease. However, SCD is multidetermined and protean, and the type of cognitive complaint associated with preclinical Alzheimer's disease needs refinement. METHODS: A total of 185 nondemented elders recruited from either the community or from a memory clinic filled a questionnaire. We searched for item responses associated with medical help seeking, cognitive deficits, and β-amyloidosis...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054024/critical-review-of-the-appropriate-use-criteria-for-amyloid-imaging-effect-on-diagnosis-and-patient-care
#17
Liana G Apostolova, Janelle M Haider, Naira Goukasian, Gil D Rabinovici, Gael Chételat, John M Ringman, Sarah Kremen, Joshua D Grill, Lucas Restrepo, Mario F Mendez, Daniel H Silverman
INTRODUCTION: The utility of the Appropriate Use Criteria (AUC) for amyloid imaging is not established. METHODS: Fifty-three cognitively impaired patients with clinical F(18)-florbetapir imaging were classified as early and late onset, as well as AUC-consistent or AUC-inconsistent. Chi-square statistics and t test were used to compare demographic characteristics and clinical outcomes as appropriate. RESULTS: Early-onset patients were more likely to be amyloid positive...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28054023/imaging-markers-of-cerebrovascular-pathologies-pathophysiology-clinical-presentation-and-risk-factors
#18
REVIEW
Mekala R Raman, Kejal Kantarci, Melissa E Murray, Clifford R Jack, Prashanthi Vemuri
Cerebrovascular pathologies (CVPs) are common pathologies associated with age-related cognitive decline along with Alzheimer disease pathologies. The impact of CVP on the prevalence of dementia is increasingly being recognized. The goal of this review is to improve our understanding of the pathophysiological underpinnings and the multimodal magnetic resonance imaging and positron emission tomography imaging changes that are associated with the hallmarks of CVP. This knowledge will facilitate the development of early detection, intervention, and prevention strategies that may contribute to lowering the risk of dementia...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27872895/the-alzheimer-s-imaging-consortium-celebrating-20%C3%A2-years-of-creativity-and-progress
#19
EDITORIAL
Mony J de Leon
No abstract text is available yet for this article.
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27872894/perspective-from-the-alzheimer-s-association-neuroimaging-professional-interest-area-of-istaart-continues-impact-on-the-field
#20
EDITORIAL
Heather M Snyder, Maria C Carrillo
No abstract text is available yet for this article.
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
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